DUSP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.23400045
2NIK/NF-kappaB signaling (GO:0038061)5.83971497
3regulation of interleukin-12 biosynthetic process (GO:0045075)5.35605538
4response to muramyl dipeptide (GO:0032495)5.07062080
5regulation of vitamin metabolic process (GO:0030656)5.00935598
6positive regulation of gamma-delta T cell activation (GO:0046645)4.96210953
7tolerance induction (GO:0002507)4.95893167
8positive thymic T cell selection (GO:0045059)4.85958893
9regulation of gamma-delta T cell differentiation (GO:0045586)4.82323020
10regulation of T-helper 1 cell differentiation (GO:0045625)4.81345270
11interferon-gamma production (GO:0032609)4.67667785
12regulation of gamma-delta T cell activation (GO:0046643)4.59190870
13negative T cell selection (GO:0043383)4.58537357
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56353205
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56353205
16negative thymic T cell selection (GO:0045060)4.55488030
17antigen processing and presentation of endogenous antigen (GO:0019883)4.49019907
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.44868142
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.38771302
20regulation of cytokine secretion involved in immune response (GO:0002739)4.23281472
21thymic T cell selection (GO:0045061)4.23167650
22positive T cell selection (GO:0043368)4.14085064
23regulation of interferon-alpha production (GO:0032647)4.02785746
24negative regulation of cell killing (GO:0031342)3.99347946
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99347946
26myeloid dendritic cell differentiation (GO:0043011)3.95848133
27T cell selection (GO:0045058)3.90269562
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.88002438
29T-helper 1 type immune response (GO:0042088)3.87515694
30activation of MAPKKK activity (GO:0000185)3.86727015
31response to interleukin-15 (GO:0070672)3.86414869
32regulation of podosome assembly (GO:0071801)3.85947590
33response to peptidoglycan (GO:0032494)3.85219230
34positive regulation of chemokine biosynthetic process (GO:0045080)3.85162028
35negative regulation of interleukin-12 production (GO:0032695)3.84814246
36JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.82312619
37CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.76939035
38CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.73768871
39T-helper cell differentiation (GO:0042093)3.73768871
40myeloid dendritic cell activation (GO:0001773)3.72092219
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71160405
42response to protozoan (GO:0001562)3.67563118
43cellular response to interleukin-15 (GO:0071350)3.64182663
44regulation of type I interferon-mediated signaling pathway (GO:0060338)3.62932061
45T cell migration (GO:0072678)3.59241454
46growth hormone receptor signaling pathway (GO:0060396)3.57951872
47positive regulation of interferon-alpha production (GO:0032727)3.55455377
48defense response to protozoan (GO:0042832)3.54369634
49leukocyte aggregation (GO:0070486)3.53169623
50germinal center formation (GO:0002467)3.49553949
51immunoglobulin mediated immune response (GO:0016064)3.45201642
52regulation of chemokine biosynthetic process (GO:0045073)3.44895870
53positive regulation of interleukin-2 production (GO:0032743)3.44686071
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40138497
55positive regulation of type 2 immune response (GO:0002830)3.37428001
56T cell differentiation involved in immune response (GO:0002292)3.36031025
57alpha-beta T cell differentiation involved in immune response (GO:0002293)3.36031025
58alpha-beta T cell activation involved in immune response (GO:0002287)3.36031025
59regulation of T cell tolerance induction (GO:0002664)3.34312316
60regulation of chronic inflammatory response (GO:0002676)3.30853178
61positive regulation of heat generation (GO:0031652)3.26921177
62regulation of immunoglobulin secretion (GO:0051023)3.26132875
63regulation of T-helper cell differentiation (GO:0045622)3.22259909
64regulation of interferon-beta biosynthetic process (GO:0045357)3.22205561
65positive regulation of isotype switching (GO:0045830)3.19508872
66macrophage activation involved in immune response (GO:0002281)3.18069935
67positive regulation of interleukin-12 production (GO:0032735)3.12948497
68branching involved in labyrinthine layer morphogenesis (GO:0060670)3.12603043
69positive regulation of T-helper cell differentiation (GO:0045624)3.11898981
70positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11342876
71regulation of alpha-beta T cell proliferation (GO:0046640)3.10833758
72regulation of response to interferon-gamma (GO:0060330)3.10601877
73natural killer cell activation (GO:0030101)3.09622395
74T cell activation involved in immune response (GO:0002286)3.07212889
75negative regulation of viral genome replication (GO:0045071)3.06366073
76antigen processing and presentation via MHC class Ib (GO:0002475)3.06188369
77positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.06054987
78T cell receptor signaling pathway (GO:0050852)3.05916172
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05552703
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05552703
81positive regulation by organism of defense response of other organism involved in symbiotic interact3.05552703
82modulation by symbiont of host immune response (GO:0052553)3.05552703
83positive regulation by symbiont of host defense response (GO:0052509)3.05552703
84modulation by symbiont of host defense response (GO:0052031)3.05552703
85negative regulation of bone resorption (GO:0045779)3.05344207
86positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.03510430
87hepatocyte apoptotic process (GO:0097284)3.02462252
88cellular response to interferon-gamma (GO:0071346)3.01797857
89cellular response to growth hormone stimulus (GO:0071378)3.01726871
90negative regulation of cytokine production involved in immune response (GO:0002719)3.01626462
91alpha-beta T cell activation (GO:0046631)3.00490837
92regulation of B cell receptor signaling pathway (GO:0050855)3.00034662
93regulation of interferon-gamma biosynthetic process (GO:0045072)2.99965664
94regulation of interleukin-2 biosynthetic process (GO:0045076)2.99460022
95alpha-beta T cell differentiation (GO:0046632)2.99005483
96regulation of isotype switching to IgG isotypes (GO:0048302)2.98816934
97regulation of membrane protein ectodomain proteolysis (GO:0051043)2.97394716
98positive regulation of NF-kappaB import into nucleus (GO:0042346)2.96925954
99negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.95376448
100interferon-gamma-mediated signaling pathway (GO:0060333)2.95295502
101nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.94838660
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92637079
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92161744
104regulation of natural killer cell mediated immunity (GO:0002715)2.92161744
105regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.91653090
106dendritic cell differentiation (GO:0097028)2.91611277
107positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90456300
108tyrosine phosphorylation of STAT protein (GO:0007260)2.90122792
109endothelial cell chemotaxis (GO:0035767)2.89272758
110mature B cell differentiation (GO:0002335)2.88700722
111regulation of T cell receptor signaling pathway (GO:0050856)2.86354439
112cellular response to arsenic-containing substance (GO:0071243)2.85800357
113positive regulation of interferon-beta production (GO:0032728)2.85760871
114positive regulation of humoral immune response (GO:0002922)2.85527013
115positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84871042
116cellular response to lipopolysaccharide (GO:0071222)2.84582484
117positive regulation of natural killer cell differentiation (GO:0032825)2.84013135
118T cell costimulation (GO:0031295)2.83127206
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82241547
120negative regulation of myeloid cell apoptotic process (GO:0033033)2.82027939
121positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.79232939
122cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.78157158
123positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.77982383
124positive regulation of natural killer cell mediated immunity (GO:0002717)2.77982383
125positive regulation of DNA recombination (GO:0045911)2.77962936
126regulation of interleukin-12 production (GO:0032655)2.77917000
127embryonic process involved in female pregnancy (GO:0060136)2.77504270
128lymphocyte costimulation (GO:0031294)2.76886131
129regulation of interleukin-2 production (GO:0032663)2.76563253
130positive regulation of interleukin-10 production (GO:0032733)2.76077359
131response to interferon-gamma (GO:0034341)2.75955837
132natural killer cell differentiation (GO:0001779)2.75311451
133protein localization to endosome (GO:0036010)2.74483776
134regulation of type 2 immune response (GO:0002828)2.74329550
135cellular response to molecule of bacterial origin (GO:0071219)2.73858549
136regulation of B cell differentiation (GO:0045577)2.73051568
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72939276
138regulation of inflammatory response to antigenic stimulus (GO:0002861)2.72894463
139B cell mediated immunity (GO:0019724)2.72602413
140leukocyte cell-cell adhesion (GO:0007159)2.72560644
141response to type I interferon (GO:0034340)2.72045406
142cellular response to virus (GO:0098586)2.71351711
143neutrophil activation (GO:0042119)2.71235884
144cellular response to type I interferon (GO:0071357)2.71106194
145type I interferon signaling pathway (GO:0060337)2.71106194
146mucosal-associated lymphoid tissue development (GO:0048537)2.68463266
147Peyers patch development (GO:0048541)2.68463266
148modulation by symbiont of host cellular process (GO:0044068)2.68086646
149CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.66858402
150positive regulation of interleukin-6 production (GO:0032755)2.66825993
151monocyte chemotaxis (GO:0002548)2.66007510
152positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65748827
153regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.65715184
154lymphocyte migration (GO:0072676)2.65650777
155regulation of mononuclear cell migration (GO:0071675)2.65468629
156positive regulation of immunoglobulin mediated immune response (GO:0002891)2.65247518
157positive regulation of B cell mediated immunity (GO:0002714)2.65247518
158antigen receptor-mediated signaling pathway (GO:0050851)2.65107125
159positive regulation of defense response to virus by host (GO:0002230)2.65089788
160regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.65021863
161positive regulation of p38MAPK cascade (GO:1900745)2.64884421
162mature B cell differentiation involved in immune response (GO:0002313)2.64624383
163granulocyte activation (GO:0036230)2.63870339
164regulation of antigen processing and presentation (GO:0002577)2.63109036
165regulation of NF-kappaB import into nucleus (GO:0042345)2.62732240
166positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.61244472
167regulation of RIG-I signaling pathway (GO:0039535)2.60388536
168positive regulation of cytokine biosynthetic process (GO:0042108)2.60340626
169regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.59692706
170positive regulation of antigen processing and presentation (GO:0002579)2.58821835
171regulation of fever generation (GO:0031620)2.58483319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.49346852
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.56489007
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.77691101
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.15898447
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.05855148
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.78581605
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.50710740
8RUNX_20019798_ChIP-Seq_JUKART_Human3.05706098
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02360411
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.97129387
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.88875398
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88248461
13MYC_22102868_ChIP-Seq_BL_Human2.87494949
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.87140562
15* MYB_26560356_Chip-Seq_TH2_Human2.69025528
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58569117
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56166002
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53082355
19MAF_26560356_Chip-Seq_TH1_Human2.51266580
20* NOTCH1_21737748_ChIP-Seq_TLL_Human2.44533782
21TCF7_22412390_ChIP-Seq_EML_Mouse2.37899534
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.33440990
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31312623
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30973722
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.26292042
26* MYB_26560356_Chip-Seq_TH1_Human2.19729435
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07761636
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02660549
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.94425907
30UTX_26944678_Chip-Seq_JUKART_Human1.94304730
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92156001
32VDR_21846776_ChIP-Seq_THP-1_Human1.91991121
33SCL_19346495_ChIP-Seq_HPC-7_Human1.91784936
34VDR_24763502_ChIP-Seq_THP-1_Human1.90119470
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.84431092
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79842358
37* KDM2B_26808549_Chip-Seq_DND41_Human1.77474482
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75902255
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.74940015
40GATA3_27048872_Chip-Seq_THYMUS_Human1.67912869
41CLOCK_20551151_ChIP-Seq_293T_Human1.64724754
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60096465
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54157197
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53563717
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51353040
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48921016
47* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43714934
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40937896
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40203380
50VDR_24787735_ChIP-Seq_THP-1_Human1.39669847
51* SPI1_23547873_ChIP-Seq_NB4_Human1.39577908
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35989587
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35989587
54* MAF_26560356_Chip-Seq_TH2_Human1.35896681
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29919210
56PU_27001747_Chip-Seq_BMDM_Mouse1.28990479
57* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28936129
58LXR_22292898_ChIP-Seq_THP-1_Human1.26653836
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22777006
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22349676
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21634174
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20520073
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20520073
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20520073
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19160182
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18967929
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.18596866
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17620307
69TFEB_21752829_ChIP-Seq_HELA_Human1.16762813
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15981443
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15959167
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14018540
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13723848
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13500037
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11504971
76* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11453562
77* SPI1_23127762_ChIP-Seq_K562_Human1.11274903
78* FOXO3_23340844_ChIP-Seq_DLD1_Human1.10961761
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08889778
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04426501
81* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03046054
82ATF3_27146783_Chip-Seq_COLON_Human1.02400867
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02387236
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01933707
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01146461
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00883564
87* NCOR1_26117541_ChIP-Seq_K562_Human0.99819638
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99290925
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98377291
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98271054
91GATA3_26560356_Chip-Seq_TH2_Human0.97997155
92* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96654182
93* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96623587
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96055596
95* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95642410
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93963340
97RACK7_27058665_Chip-Seq_MCF-7_Human0.93638645
98* GATA2_21666600_ChIP-Seq_HMVEC_Human0.93623218
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92957270
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92592993
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92224750
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92202986
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90422254
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89864401
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.89531743
106* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88887269
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88349460
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.87109192
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86857724
110* KDM2B_26808549_Chip-Seq_K562_Human0.86766492
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84441937
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80832028
113* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79696643
114* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78526702
115GATA1_19941826_ChIP-Seq_K562_Human0.78235755
116SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76943122
117GATA2_19941826_ChIP-Seq_K562_Human0.75060371
118* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73726145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.56633888
2MP0004510_myositis3.30919589
3MP0001835_abnormal_antigen_presentation3.28790346
4MP0003763_abnormal_thymus_physiology3.22170601
5MP0005671_abnormal_response_to3.13068548
6MP0005387_immune_system_phenotype3.09022968
7MP0001790_abnormal_immune_system3.09022968
8MP0003436_decreased_susceptibility_to3.08221750
9MP0005000_abnormal_immune_tolerance2.92942439
10MP0002138_abnormal_hepatobiliary_system2.85582013
11MP0002877_abnormal_melanocyte_morpholog2.78116353
12MP0001800_abnormal_humoral_immune2.75761361
13MP0005451_abnormal_body_composition2.73259502
14MP0003303_peritoneal_inflammation2.67733580
15MP0009785_altered_susceptibility_to2.60457264
16MP0004947_skin_inflammation2.60298018
17MP0009840_abnormal_foam_cell2.52211775
18MP0002723_abnormal_immune_serum2.49662116
19MP0003300_gastrointestinal_ulcer2.47870419
20MP0002405_respiratory_system_inflammati2.46025357
21MP0002452_abnormal_antigen_presenting2.43878181
22MP0002148_abnormal_hypersensitivity_rea2.35363102
23MP0002420_abnormal_adaptive_immunity2.32164256
24MP0001819_abnormal_immune_cell2.31851374
25MP0002166_altered_tumor_susceptibility2.31201432
26MP0010352_gastrointestinal_tract_polyps2.26481546
27MP0001853_heart_inflammation2.13333912
28MP0005025_abnormal_response_to2.09362153
29MP0010155_abnormal_intestine_physiology2.08541549
30MP0002006_tumorigenesis2.08303301
31MP0005058_abnormal_lysosome_morphology2.06972010
32MP0003724_increased_susceptibility_to2.01988809
33MP0002398_abnormal_bone_marrow2.01644128
34MP0002419_abnormal_innate_immunity1.94858232
35MP0001873_stomach_inflammation1.88889374
36MP0002139_abnormal_hepatobiliary_system1.88706513
37MP0000716_abnormal_immune_system1.87136478
38MP0005076_abnormal_cell_differentiation1.86154434
39MP0006082_CNS_inflammation1.80435200
40MP0002933_joint_inflammation1.77473369
41MP0003866_abnormal_defecation1.76448739
42MP0000703_abnormal_thymus_morphology1.74587896
43MP0001348_abnormal_lacrimal_gland1.74177968
44MP0002254_reproductive_system_inflammat1.69074142
45MP0009333_abnormal_splenocyte_physiolog1.65623424
46MP0001533_abnormal_skeleton_physiology1.62117085
47MP0003075_altered_response_to1.61730323
48MP0000858_altered_metastatic_potential1.61266118
49MP0002722_abnormal_immune_system1.60883503
50MP0001845_abnormal_inflammatory_respons1.60347162
51MP0003448_altered_tumor_morphology1.55291353
52MP0009278_abnormal_bone_marrow1.54755175
53MP0005310_abnormal_salivary_gland1.53808071
54MP0008004_abnormal_stomach_pH1.52086463
55MP0004808_abnormal_hematopoietic_stem1.48271058
56MP0000689_abnormal_spleen_morphology1.47721602
57MP0002429_abnormal_blood_cell1.45629611
58MP0002332_abnormal_exercise_endurance1.45457985
59MP0003453_abnormal_keratinocyte_physiol1.45028288
60MP0002998_abnormal_bone_remodeling1.43151337
61MP0005397_hematopoietic_system_phenotyp1.34589955
62MP0001545_abnormal_hematopoietic_system1.34589955
63MP0001851_eye_inflammation1.31610979
64MP0002009_preneoplasia1.25891408
65MP0005464_abnormal_platelet_physiology1.24488093
66MP0005166_decreased_susceptibility_to1.21840736
67MP0006054_spinal_hemorrhage1.12127344
68MP0002277_abnormal_respiratory_mucosa1.11155822
69MP0008007_abnormal_cellular_replicative1.11088745
70MP0003091_abnormal_cell_migration1.10687650
71MP0000465_gastrointestinal_hemorrhage1.08178372
72MP0003566_abnormal_cell_adhesion1.07424645
73MP0008961_abnormal_basal_metabolism1.05765205
74MP0003950_abnormal_plasma_membrane1.05459673
75MP0000604_amyloidosis1.04944992
76MP0003045_fibrosis1.04886123
77MP0002396_abnormal_hematopoietic_system1.03066890
78MP0001216_abnormal_epidermal_layer1.02800200
79MP0002163_abnormal_gland_morphology1.00610625
80MP0010234_abnormal_vibrissa_follicle1.00170269
81MP0003172_abnormal_lysosome_physiology0.99950242
82MP0005165_increased_susceptibility_to0.99330354
83MP0001243_abnormal_dermal_layer0.98352977
84MP0005164_abnormal_response_to0.96439892
85MP0003191_abnormal_cellular_cholesterol0.96274870
86MP0005390_skeleton_phenotype0.96232540
87MP0000490_abnormal_crypts_of0.94379486
88MP0003656_abnormal_erythrocyte_physiolo0.92548894
89MP0001881_abnormal_mammary_gland0.91812880
90MP0008469_abnormal_protein_level0.90333211
91MP0003795_abnormal_bone_structure0.89330671
92MP0003828_pulmonary_edema0.87882417
93MP0010307_abnormal_tumor_latency0.84529328
94MP0003806_abnormal_nucleotide_metabolis0.83886687
95MP0002693_abnormal_pancreas_physiology0.82778068
96MP0003183_abnormal_peptide_metabolism0.82033351
97MP0008057_abnormal_DNA_replication0.80345051
98MP0002060_abnormal_skin_morphology0.79741330
99MP0008260_abnormal_autophagy0.79542530
100MP0005023_abnormal_wound_healing0.77993276
101MP0001191_abnormal_skin_condition0.77906870
102MP0005167_abnormal_blood-brain_barrier0.76874109
103MP0002019_abnormal_tumor_incidence0.76173526
104MP0009764_decreased_sensitivity_to0.75740110
105MP0009765_abnormal_xenobiotic_induced0.74945458
106MP0002796_impaired_skin_barrier0.72170805
107MP0001727_abnormal_embryo_implantation0.71336090
108MP0000249_abnormal_blood_vessel0.69569525
109MP0000627_abnormal_mammary_gland0.68490729
110MP0003705_abnormal_hypodermis_morpholog0.66045912
111MP0008874_decreased_physiological_sensi0.65300869
112MP0003221_abnormal_cardiomyocyte_apopto0.64402639
113MP0005174_abnormal_tail_pigmentation0.59889119
114MP0000343_altered_response_to0.57855034
115MP0009763_increased_sensitivity_to0.56723117
116MP0000367_abnormal_coat/_hair0.56681276
117MP0004264_abnormal_extraembryonic_tissu0.56628034
118MP0002132_abnormal_respiratory_system0.55992953
119MP0002136_abnormal_kidney_physiology0.55436268
120MP0000613_abnormal_salivary_gland0.55167138
121MP0001502_abnormal_circadian_rhythm0.52575190
122MP0001542_abnormal_bone_strength0.52318254
123MP0001663_abnormal_digestive_system0.51484901
124MP0005621_abnormal_cell_physiology0.51243507

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.20794638
2Optic neuritis (HP:0100653)5.20794638
3Stomatitis (HP:0010280)5.15992755
4Abnormality of glycolipid metabolism (HP:0010969)5.01606810
5Abnormality of liposaccharide metabolism (HP:0010968)5.01606810
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.01606810
7Myositis (HP:0100614)4.99233060
8Orchitis (HP:0100796)4.94916693
9Eczematoid dermatitis (HP:0000976)4.73620418
10Elevated erythrocyte sedimentation rate (HP:0003565)4.62096489
11Increased density of long bones (HP:0006392)3.98411386
12Recurrent fungal infections (HP:0002841)3.92726647
13Abnormality of T cell number (HP:0011839)3.75954239
14T lymphocytopenia (HP:0005403)3.69487795
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.66355529
16Persistence of primary teeth (HP:0006335)3.61609332
17Pulmonary infiltrates (HP:0002113)3.55491586
18Vacuolated lymphocytes (HP:0001922)3.52977637
19Arterial thrombosis (HP:0004420)3.49634060
20Nuclear cataract (HP:0100018)3.49592514
21Loss of speech (HP:0002371)3.49214946
22Mediastinal lymphadenopathy (HP:0100721)3.41522403
23Increased IgE level (HP:0003212)3.40196647
24Nasal polyposis (HP:0100582)3.37474250
25Vasculitis (HP:0002633)3.37148977
26Keratoconjunctivitis sicca (HP:0001097)3.36194887
27IgM deficiency (HP:0002850)3.33387866
28Recurrent bronchitis (HP:0002837)3.31103982
29Abnormality of T cells (HP:0002843)3.29976986
30Severe combined immunodeficiency (HP:0004430)3.29000817
31Gastrointestinal infarctions (HP:0005244)3.20828776
32Recurrent viral infections (HP:0004429)3.19806180
33Dysostosis multiplex (HP:0000943)3.18735028
34Chronic otitis media (HP:0000389)3.07076531
35Keratoconjunctivitis (HP:0001096)3.02553286
36Thyroiditis (HP:0100646)3.02467922
37Abnormality of T cell physiology (HP:0011840)2.99619568
38Panhypogammaglobulinemia (HP:0003139)2.92789789
39Increased IgM level (HP:0003496)2.88578949
40Recurrent abscess formation (HP:0002722)2.84516029
41Abnormality of the nasal mucosa (HP:0000433)2.83400872
42Recurrent cutaneous fungal infections (HP:0011370)2.80507316
43Chronic mucocutaneous candidiasis (HP:0002728)2.80507316
44Disinhibition (HP:0000734)2.78376361
45Abnormality of B cell number (HP:0010975)2.73962780
46B lymphocytopenia (HP:0010976)2.73962780
47Increased cerebral lipofuscin (HP:0011813)2.72793900
48Leukocytosis (HP:0001974)2.72728825
49Hemoptysis (HP:0002105)2.72360461
50Combined immunodeficiency (HP:0005387)2.71132045
51Meningitis (HP:0001287)2.69934854
52Systemic lupus erythematosus (HP:0002725)2.69125223
53IgG deficiency (HP:0004315)2.69076777
54Interstitial pulmonary disease (HP:0006530)2.67167430
55Inflammation of the large intestine (HP:0002037)2.65821175
56Autoimmune hemolytic anemia (HP:0001890)2.58475717
57Recurrent bacterial skin infections (HP:0005406)2.58059583
58Abnormality of eosinophils (HP:0001879)2.58040325
59Abnormality of the fingertips (HP:0001211)2.57970420
60IgA deficiency (HP:0002720)2.53282688
61Neurofibrillary tangles (HP:0002185)2.50541312
62Gastrointestinal inflammation (HP:0004386)2.48716757
63Colitis (HP:0002583)2.48243768
64Joint swelling (HP:0001386)2.45206377
65Parakeratosis (HP:0001036)2.42284060
66Axonal loss (HP:0003447)2.39349045
67Myocardial infarction (HP:0001658)2.37745268
68Thrombocytosis (HP:0001894)2.37135051
69Hypergammaglobulinemia (HP:0010702)2.36391226
70Eosinophilia (HP:0001880)2.34653639
71Cellulitis (HP:0100658)2.34387785
72Malnutrition (HP:0004395)2.33531970
73Fatigue (HP:0012378)2.32718272
74Gingivitis (HP:0000230)2.29639017
75Encephalitis (HP:0002383)2.29462484
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.28390887
77Lymphopenia (HP:0001888)2.28378358
78Chest pain (HP:0100749)2.28032171
79Apathy (HP:0000741)2.26382121
80Restrictive lung disease (HP:0002091)2.24711961
81Tetraparesis (HP:0002273)2.24216176
82Increased serum ferritin (HP:0003281)2.21156083
83Hypertensive crisis (HP:0100735)2.20513023
84Abnormality of the nasal septum (HP:0000419)2.19373226
85Abnormality of macrophages (HP:0004311)2.17829002
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17627138
87Abnormality of polysaccharide metabolism (HP:0011012)2.17627138
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17627138
89Pustule (HP:0200039)2.17447700
90Chronic diarrhea (HP:0002028)2.16037696
91Agammaglobulinemia (HP:0004432)2.15769454
92Gangrene (HP:0100758)2.12109687
93Recurrent skin infections (HP:0001581)2.11550883
94Urticaria (HP:0001025)2.11548561
95Diminished motivation (HP:0000745)2.11143756
96Emphysema (HP:0002097)2.09644308
97Mucopolysacchariduria (HP:0008155)2.09025901
98Urinary glycosaminoglycan excretion (HP:0003541)2.09025901
99Segmental peripheral demyelination/remyelination (HP:0003481)2.08663017
100Anhidrosis (HP:0000970)2.08479728
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.07168269
102Glomerulopathy (HP:0100820)2.05460253
103Anorexia (HP:0002039)2.04647153
104Autoimmune thrombocytopenia (HP:0001973)2.03653767
105Thoracolumbar scoliosis (HP:0002944)2.02327036
106Hyperparathyroidism (HP:0000843)2.02138679
107Gastrointestinal stroma tumor (HP:0100723)2.01550159
108Premature loss of primary teeth (HP:0006323)2.01058924
109Abnormality of the pericardium (HP:0001697)2.00519998
110Polyneuropathy (HP:0001271)1.99453290
111Mutism (HP:0002300)1.98635569
112Arthralgia (HP:0002829)1.97883003
113Periodontitis (HP:0000704)1.97634818
114Upper motor neuron abnormality (HP:0002127)1.97549751
115Basal ganglia calcification (HP:0002135)1.97233112
116Granulocytopenia (HP:0001913)1.97175255
117Osteomyelitis (HP:0002754)1.95073377
118Spontaneous hematomas (HP:0007420)1.94769214
119Xerostomia (HP:0000217)1.93118702
120Acute myeloid leukemia (HP:0004808)1.92750871
121Amaurosis fugax (HP:0100576)1.92249876
122Cerebral inclusion bodies (HP:0100314)1.91725778
123Neuronal loss in central nervous system (HP:0002529)1.91071574
124Thin bony cortex (HP:0002753)1.90251090
125Bone pain (HP:0002653)1.88604018
126Pulmonary embolism (HP:0002204)1.88448012
127Bronchitis (HP:0012387)1.87560452
128Obstructive lung disease (HP:0006536)1.86875075
129Chronic obstructive pulmonary disease (HP:0006510)1.86875075
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85832296
131Chronic sinusitis (HP:0011109)1.85740532
132Lymphoma (HP:0002665)1.85568611
133Hematochezia (HP:0002573)1.85465762
134Progressive neurologic deterioration (HP:0002344)1.85072788
135Abnormality of the pleura (HP:0002103)1.84871155
136Peritonitis (HP:0002586)1.83438723
137Glomerulonephritis (HP:0000099)1.82871754
138Thick nail (HP:0001805)1.82260003
139Keratitis (HP:0000491)1.80532073
140Spondylolisthesis (HP:0003302)1.80345777
141Cheilitis (HP:0100825)1.80173314
142Recurrent gram-negative bacterial infections (HP:0005420)1.78033344
143Vertebral compression fractures (HP:0002953)1.78026832
144Stomach cancer (HP:0012126)1.75603551
145Gingival bleeding (HP:0000225)1.70726499
146Skin ulcer (HP:0200042)1.69840750
147Lip pit (HP:0100267)1.66075917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.52923226
2TXK3.76553361
3PRPF4B3.76146165
4MAP4K13.74235853
5TBK12.84218320
6IKBKB2.76440301
7JAK32.70241231
8IRAK32.69217749
9MAP3K102.57805785
10IKBKE2.57504524
11CHUK2.47562627
12EPHB12.27804464
13ITK2.13000561
14EPHA32.12272647
15TYK22.00895575
16DDR21.94976930
17JAK11.94218280
18ZAP701.92159358
19GRK71.87445253
20MOS1.87382311
21FGFR41.77208879
22TAOK31.74906784
23NLK1.74828562
24MST41.72676945
25MAP3K31.68705983
26MATK1.68376926
27MAP2K31.63227430
28RPS6KA41.53529602
29STK101.51651530
30PIM21.47668882
31TSSK61.44811869
32IRAK41.44477451
33PIM11.43627076
34RIPK11.43109325
35FGFR31.41747057
36MAP3K131.33497349
37BTK1.31202726
38MAP3K111.30489876
39TEC1.30105467
40ARAF1.23669217
41LATS21.22292355
42MAP3K91.18496224
43HIPK21.17374452
44PTK61.15851414
45CDC42BPA1.15338311
46HCK1.14789719
47EEF2K1.14579878
48MAPK151.14354299
49LCK1.14238069
50CSK1.13627220
51GRK61.13063530
52TRIB31.13056424
53IRAK11.11169532
54FGR1.07603765
55SIK31.07542000
56EIF2AK31.06082375
57MST1R1.02568867
58TAOK10.98679661
59FLT30.98581999
60ERBB40.93679080
61SYK0.92416270
62IRAK20.91592767
63PDGFRA0.91294971
64PAK40.91024982
65ERN10.89160936
66KIT0.85585294
67CDK120.84944820
68JAK20.81911887
69SMG10.80351145
70RIPK40.80159144
71RPS6KA50.79966347
72EPHA20.78478936
73LRRK20.77853011
74ICK0.76903211
75MARK30.75893110
76MAP3K10.74673880
77DMPK0.73467666
78BMX0.70018948
79MAP2K20.69932233
80TAOK20.67856676
81PDGFRB0.66796421
82MAPKAPK20.65604990
83RPS6KA10.61848696
84MAP3K20.60983920
85MELK0.56906263
86GSK3A0.56757001
87CLK10.56692410
88ALK0.55650040
89ABL20.53889516
90PRKCQ0.51340837
91BRAF0.50994931
92CDK90.50723317
93PKN20.48657924
94TGFBR20.47408478
95SIK20.46711369
96BRD40.46702478
97TESK10.45961387
98MAPK110.42491388
99NME20.42147259
100DAPK30.40782402
101RET0.40245387
102TRPM70.40178392
103RPS6KB20.40044855
104MAPKAPK50.39212211
105CDK60.39154017
106STK240.39043488
107PTK20.38143685
108MAPK70.37731762
109RPS6KA60.37282898
110LYN0.36104772
111ABL10.35509676
112BMPR20.35281989
113BLK0.35160098
114SIK10.35127947
115PASK0.34195997
116CSF1R0.33939072
117TYRO30.33356301
118CDK40.33033157
119INSR0.32848049
120MAP3K80.32490542
121TTN0.32133078
122MAP3K50.32032762
123MAPKAPK30.31203527
124DYRK1B0.30392510
125PIK3CG0.29695779
126TESK20.29601598
127NEK90.29520390
128MAPK40.29021866
129TGFBR10.28521740
130MAP3K70.27644266
131PDK10.27447148
132PDPK10.26538968
133EIF2AK20.24885087
134EGFR0.24855753
135PKN10.24275703

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.93669239
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78694656
3Graft-versus-host disease_Homo sapiens_hsa053322.71138772
4Primary immunodeficiency_Homo sapiens_hsa053402.51758711
5Osteoclast differentiation_Homo sapiens_hsa043802.51408830
6Allograft rejection_Homo sapiens_hsa053302.49978784
7Leishmaniasis_Homo sapiens_hsa051402.49497369
8T cell receptor signaling pathway_Homo sapiens_hsa046602.34672381
9Measles_Homo sapiens_hsa051622.32906298
10TNF signaling pathway_Homo sapiens_hsa046682.24055695
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.23915068
12Antigen processing and presentation_Homo sapiens_hsa046122.06436878
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99129638
14Toxoplasmosis_Homo sapiens_hsa051451.90957296
15B cell receptor signaling pathway_Homo sapiens_hsa046621.83337773
16Other glycan degradation_Homo sapiens_hsa005111.74356607
17Legionellosis_Homo sapiens_hsa051341.74143960
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72860975
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.71936293
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69393592
21Acute myeloid leukemia_Homo sapiens_hsa052211.63072323
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62945985
23Autoimmune thyroid disease_Homo sapiens_hsa053201.58072890
24Apoptosis_Homo sapiens_hsa042101.57298272
25Staphylococcus aureus infection_Homo sapiens_hsa051501.51569985
26Type I diabetes mellitus_Homo sapiens_hsa049401.50260293
27Influenza A_Homo sapiens_hsa051641.46872023
28Prolactin signaling pathway_Homo sapiens_hsa049171.44688192
29Chronic myeloid leukemia_Homo sapiens_hsa052201.42523404
30Shigellosis_Homo sapiens_hsa051311.38656448
31Herpes simplex infection_Homo sapiens_hsa051681.37954322
32Hematopoietic cell lineage_Homo sapiens_hsa046401.36467195
33Hepatitis B_Homo sapiens_hsa051611.35211301
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33544636
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31844572
36Viral myocarditis_Homo sapiens_hsa054161.29450461
37Lysosome_Homo sapiens_hsa041421.28624989
38Chemokine signaling pathway_Homo sapiens_hsa040621.27788908
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26327303
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23141198
41Malaria_Homo sapiens_hsa051441.22728052
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.22587647
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15032534
44Prion diseases_Homo sapiens_hsa050201.11396108
45Tuberculosis_Homo sapiens_hsa051521.09137411
46Rheumatoid arthritis_Homo sapiens_hsa053231.07011419
47Pertussis_Homo sapiens_hsa051331.06018698
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05727008
49Small cell lung cancer_Homo sapiens_hsa052221.04221630
50HTLV-I infection_Homo sapiens_hsa051661.03454848
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03391849
52Epstein-Barr virus infection_Homo sapiens_hsa051691.02658345
53Pancreatic cancer_Homo sapiens_hsa052121.00873262
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99161361
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98561045
56Salmonella infection_Homo sapiens_hsa051320.98375425
57Hepatitis C_Homo sapiens_hsa051600.97388618
58Circadian rhythm_Homo sapiens_hsa047100.97002287
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.94755184
60Asthma_Homo sapiens_hsa053100.92197038
61VEGF signaling pathway_Homo sapiens_hsa043700.90902940
62Viral carcinogenesis_Homo sapiens_hsa052030.87468273
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81830485
64Platelet activation_Homo sapiens_hsa046110.79660362
65FoxO signaling pathway_Homo sapiens_hsa040680.79181817
66p53 signaling pathway_Homo sapiens_hsa041150.77409819
67* MAPK signaling pathway_Homo sapiens_hsa040100.77035208
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.76854325
69Phagosome_Homo sapiens_hsa041450.76262920
70Colorectal cancer_Homo sapiens_hsa052100.75072017
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.71128360
72Insulin resistance_Homo sapiens_hsa049310.68696741
73MicroRNAs in cancer_Homo sapiens_hsa052060.67527930
74Systemic lupus erythematosus_Homo sapiens_hsa053220.66766224
75Prostate cancer_Homo sapiens_hsa052150.66126311
76Proteoglycans in cancer_Homo sapiens_hsa052050.64463057
77Type II diabetes mellitus_Homo sapiens_hsa049300.63993436
78African trypanosomiasis_Homo sapiens_hsa051430.63411098
79Amoebiasis_Homo sapiens_hsa051460.60882539
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59720342
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57996457
82Sphingolipid metabolism_Homo sapiens_hsa006000.57469429
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55181804
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54132602
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53610594
86HIF-1 signaling pathway_Homo sapiens_hsa040660.53204562
87Non-small cell lung cancer_Homo sapiens_hsa052230.51538428
88Adherens junction_Homo sapiens_hsa045200.50670264
89Renal cell carcinoma_Homo sapiens_hsa052110.49868980
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49679444
91Focal adhesion_Homo sapiens_hsa045100.47215767
92Endocytosis_Homo sapiens_hsa041440.46978367
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46425268
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46218860
95Endometrial cancer_Homo sapiens_hsa052130.45716705
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44656171
97Estrogen signaling pathway_Homo sapiens_hsa049150.43067838
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42632751
99Pathways in cancer_Homo sapiens_hsa052000.41932678
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41808784
101ErbB signaling pathway_Homo sapiens_hsa040120.40744187
102Sulfur metabolism_Homo sapiens_hsa009200.40252699
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39719305
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.39440512
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38428773
106Notch signaling pathway_Homo sapiens_hsa043300.37107255
107Inositol phosphate metabolism_Homo sapiens_hsa005620.36467945
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36338833
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35932380
110Fructose and mannose metabolism_Homo sapiens_hsa000510.35825547
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35631067
112Dorso-ventral axis formation_Homo sapiens_hsa043200.34469567
113mTOR signaling pathway_Homo sapiens_hsa041500.34051039
114Vibrio cholerae infection_Homo sapiens_hsa051100.32467168
115TGF-beta signaling pathway_Homo sapiens_hsa043500.30640572
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30382850
117Bladder cancer_Homo sapiens_hsa052190.30336066
118Galactose metabolism_Homo sapiens_hsa000520.27281158
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25378745
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.22895757

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