

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of hippo signaling (GO:0035330) | 6.89723991 |
| 2 | protein maturation by protein folding (GO:0022417) | 6.62909028 |
| 3 | GMP metabolic process (GO:0046037) | 6.14648967 |
| 4 | proline metabolic process (GO:0006560) | 6.07419834 |
| 5 | piRNA metabolic process (GO:0034587) | 6.06708567 |
| 6 | glial cell proliferation (GO:0014009) | 5.90058590 |
| 7 | neural tube formation (GO:0001841) | 5.66336621 |
| 8 | 4-hydroxyproline metabolic process (GO:0019471) | 5.61534100 |
| 9 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 5.44313927 |
| 10 | cornea development in camera-type eye (GO:0061303) | 5.28778664 |
| 11 | lung morphogenesis (GO:0060425) | 5.01742614 |
| 12 | DNA methylation involved in gamete generation (GO:0043046) | 4.88981176 |
| 13 | limb bud formation (GO:0060174) | 4.84092056 |
| 14 | cell junction maintenance (GO:0034331) | 4.71044284 |
| 15 | proline biosynthetic process (GO:0006561) | 4.70524851 |
| 16 | cell-cell junction maintenance (GO:0045217) | 4.61120425 |
| 17 | tryptophan catabolic process (GO:0006569) | 4.59304356 |
| 18 | indole-containing compound catabolic process (GO:0042436) | 4.59304356 |
| 19 | indolalkylamine catabolic process (GO:0046218) | 4.59304356 |
| 20 | negative regulation of glial cell proliferation (GO:0060253) | 4.49713071 |
| 21 | lens morphogenesis in camera-type eye (GO:0002089) | 4.47265403 |
| 22 | eyelid development in camera-type eye (GO:0061029) | 4.44328393 |
| 23 | negative regulation of cell size (GO:0045792) | 4.19678655 |
| 24 | cardiac ventricle formation (GO:0003211) | 4.17979689 |
| 25 | nucleoside diphosphate biosynthetic process (GO:0009133) | 4.17611073 |
| 26 | clathrin coat assembly (GO:0048268) | 4.09284469 |
| 27 | negative regulation of T cell differentiation in thymus (GO:0033085) | 4.02574902 |
| 28 | snRNA transcription (GO:0009301) | 3.96575237 |
| 29 | GDP-mannose metabolic process (GO:0019673) | 3.95872691 |
| 30 | response to phenylpropanoid (GO:0080184) | 3.88259863 |
| 31 | meiotic chromosome segregation (GO:0045132) | 3.87414959 |
| 32 | positive regulation of vascular permeability (GO:0043117) | 3.85589403 |
| 33 | sympathetic nervous system development (GO:0048485) | 3.84290415 |
| 34 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.83669919 |
| 35 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 3.83548137 |
| 36 | cardiac chamber formation (GO:0003207) | 3.77747123 |
| 37 | spinal cord development (GO:0021510) | 3.77046917 |
| 38 | drinking behavior (GO:0042756) | 3.71214650 |
| 39 | purine deoxyribonucleotide metabolic process (GO:0009151) | 3.71102519 |
| 40 | single strand break repair (GO:0000012) | 3.71075523 |
| 41 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.69050524 |
| 42 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.69050524 |
| 43 | negative regulation of digestive system process (GO:0060457) | 3.63732628 |
| 44 | tryptophan metabolic process (GO:0006568) | 3.62175929 |
| 45 | male meiosis (GO:0007140) | 3.61015091 |
| 46 | somite development (GO:0061053) | 3.57360141 |
| 47 | Golgi transport vesicle coating (GO:0048200) | 3.49517567 |
| 48 | COPI coating of Golgi vesicle (GO:0048205) | 3.49517567 |
| 49 | negative regulation of adherens junction organization (GO:1903392) | 3.48209880 |
| 50 | negative regulation of focal adhesion assembly (GO:0051895) | 3.48209880 |
| 51 | negative regulation of cell junction assembly (GO:1901889) | 3.48209880 |
| 52 | myoblast migration (GO:0051451) | 3.44104860 |
| 53 | phagocytosis, recognition (GO:0006910) | 3.44025205 |
| 54 | cellular component maintenance (GO:0043954) | 3.41521488 |
| 55 | lung epithelium development (GO:0060428) | 3.37639041 |
| 56 | positive regulation of transcription from RNA polymerase III promoter (GO:0045945) | 3.34765745 |
| 57 | morphogenesis of an epithelial sheet (GO:0002011) | 3.33488023 |
| 58 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.32778981 |
| 59 | negative regulation of fibrinolysis (GO:0051918) | 3.29675582 |
| 60 | purine nucleoside diphosphate metabolic process (GO:0009135) | 3.28672887 |
| 61 | purine ribonucleoside diphosphate metabolic process (GO:0009179) | 3.28672887 |
| 62 | regulation of integrin-mediated signaling pathway (GO:2001044) | 3.26473412 |
| 63 | positive regulation of collagen biosynthetic process (GO:0032967) | 3.22473685 |
| 64 | seminiferous tubule development (GO:0072520) | 3.17836031 |
| 65 | regulation of translational fidelity (GO:0006450) | 3.15737160 |
| 66 | regulation of metalloenzyme activity (GO:0048552) | 3.11087459 |
| 67 | regulation of cell migration involved in sprouting angiogenesis (GO:0090049) | 3.09157823 |
| 68 | regulation of female receptivity (GO:0045924) | 3.06609453 |
| 69 | regulation of cofactor metabolic process (GO:0051193) | 3.06177593 |
| 70 | regulation of coenzyme metabolic process (GO:0051196) | 3.06177593 |
| 71 | regulation of cholesterol homeostasis (GO:2000188) | 3.05805724 |
| 72 | positive regulation of protein targeting to membrane (GO:0090314) | 3.03949243 |
| 73 | acrosome reaction (GO:0007340) | 3.02067925 |
| 74 | positive regulation of collagen metabolic process (GO:0010714) | 3.00612346 |
| 75 | ventricular septum morphogenesis (GO:0060412) | 3.00179300 |
| 76 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.97105926 |
| 77 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.86320323 |
| 78 | endothelial cell proliferation (GO:0001935) | 2.86099597 |
| 79 | aromatic amino acid family catabolic process (GO:0009074) | 2.86005924 |
| 80 | positive regulation of vesicle fusion (GO:0031340) | 2.81328097 |
| 81 | coenzyme catabolic process (GO:0009109) | 2.81049207 |
| 82 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.80364088 |
| 83 | response to redox state (GO:0051775) | 2.78970639 |
| 84 | vesicle coating (GO:0006901) | 2.75978469 |
| 85 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.74510619 |
| 86 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.73421866 |
| 87 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.71283974 |
| 88 | protein carboxylation (GO:0018214) | 2.71283974 |
| 89 | protein retention in ER lumen (GO:0006621) | 2.69874639 |
| 90 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.69600559 |
| 91 | oligodendrocyte development (GO:0014003) | 2.66943847 |
| 92 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.66578341 |
| 93 | establishment of epithelial cell polarity (GO:0090162) | 2.65143871 |
| 94 | endothelial cell morphogenesis (GO:0001886) | 2.60877826 |
| 95 | snRNA metabolic process (GO:0016073) | 2.60832205 |
| 96 | fusion of sperm to egg plasma membrane (GO:0007342) | 2.60298058 |
| 97 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.58934883 |
| 98 | cholesterol efflux (GO:0033344) | 2.58884242 |
| 99 | isoprenoid biosynthetic process (GO:0008299) | 2.57747535 |
| 100 | positive regulation of bone resorption (GO:0045780) | 2.57401929 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 6.53525501 |
| 2 | ZNF263_19887448_ChIP-Seq_K562_Human | 4.81945017 |
| 3 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 4.29969628 |
| 4 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 4.22320014 |
| 5 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 3.94963129 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.24950925 |
| 7 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.18255480 |
| 8 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.48763736 |
| 9 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.45155830 |
| 10 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 2.43300430 |
| 11 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.31670816 |
| 12 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.24884485 |
| 13 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.16216419 |
| 14 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.16104823 |
| 15 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.99992831 |
| 16 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.99838642 |
| 17 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.90493275 |
| 18 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.86395982 |
| 19 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.85173133 |
| 20 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.83554228 |
| 21 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.81873050 |
| 22 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.80763706 |
| 23 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.75406474 |
| 24 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.71276409 |
| 25 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.70377309 |
| 26 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.68902339 |
| 27 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.67236558 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.58652774 |
| 29 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.58554859 |
| 30 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.57315030 |
| 31 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.57044618 |
| 32 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.55115158 |
| 33 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.50825458 |
| 34 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.50441010 |
| 35 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.50308112 |
| 36 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.45831540 |
| 37 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.44390159 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.38344803 |
| 39 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.38150012 |
| 40 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.37774967 |
| 41 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.37631464 |
| 42 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.37387859 |
| 43 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.37384164 |
| 44 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.33264475 |
| 45 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.32922592 |
| 46 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.32429073 |
| 47 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.31026309 |
| 48 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.27135965 |
| 49 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.26932618 |
| 50 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.25601358 |
| 51 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.24599820 |
| 52 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.23740615 |
| 53 | KDM2B_26808549_Chip-Seq_K562_Human | 1.23414327 |
| 54 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.22308018 |
| 55 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.22210627 |
| 56 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.21049782 |
| 57 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.20448555 |
| 58 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.20431394 |
| 59 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.18340799 |
| 60 | ATF3_27146783_Chip-Seq_COLON_Human | 1.15099885 |
| 61 | P68_20966046_ChIP-Seq_HELA_Human | 1.14779617 |
| 62 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.13781253 |
| 63 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.13605167 |
| 64 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.13365215 |
| 65 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.12285587 |
| 66 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.11537411 |
| 67 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.11032185 |
| 68 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.10183148 |
| 69 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.09973246 |
| 70 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.09197752 |
| 71 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.08310044 |
| 72 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.08050229 |
| 73 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.06313759 |
| 74 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.05950634 |
| 75 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.05762940 |
| 76 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.05539144 |
| 77 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.04793629 |
| 78 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.04495012 |
| 79 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.03748959 |
| 80 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.03623423 |
| 81 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.00788979 |
| 82 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.98798797 |
| 83 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.95558782 |
| 84 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.95460593 |
| 85 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.95396272 |
| 86 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.94872959 |
| 87 | LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.94742816 |
| 88 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.94020724 |
| 89 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.93889470 |
| 90 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.93055774 |
| 91 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.92855404 |
| 92 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.92008066 |
| 93 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.91736538 |
| 94 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.91714343 |
| 95 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.91706550 |
| 96 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.89404986 |
| 97 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.87700948 |
| 98 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.87000882 |
| 99 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.86778125 |
| 100 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.86755852 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005451_abnormal_body_composition | 5.07235868 |
| 2 | MP0004147_increased_porphyrin_level | 5.05910683 |
| 3 | MP0006054_spinal_hemorrhage | 4.34491095 |
| 4 | MP0002089_abnormal_postnatal_growth/wei | 3.58754647 |
| 5 | MP0008057_abnormal_DNA_replication | 3.51749870 |
| 6 | MP0003705_abnormal_hypodermis_morpholog | 2.53067443 |
| 7 | MP0003122_maternal_imprinting | 2.45426858 |
| 8 | MP0004272_abnormal_basement_membrane | 2.44130706 |
| 9 | MP0005360_urolithiasis | 2.44065714 |
| 10 | MP0008875_abnormal_xenobiotic_pharmacok | 2.38980319 |
| 11 | MP0003115_abnormal_respiratory_system | 2.36665245 |
| 12 | MP0005409_darkened_coat_color | 2.36644630 |
| 13 | MP0000003_abnormal_adipose_tissue | 2.27886043 |
| 14 | MP0003191_abnormal_cellular_cholesterol | 2.26437088 |
| 15 | MP0004134_abnormal_chest_morphology | 2.13044797 |
| 16 | MP0001661_extended_life_span | 1.96268811 |
| 17 | MP0008438_abnormal_cutaneous_collagen | 1.94416381 |
| 18 | MP0003385_abnormal_body_wall | 1.93617542 |
| 19 | MP0002751_abnormal_autonomic_nervous | 1.86300250 |
| 20 | MP0000013_abnormal_adipose_tissue | 1.84072996 |
| 21 | MP0003123_paternal_imprinting | 1.66740144 |
| 22 | MP0005375_adipose_tissue_phenotype | 1.55510401 |
| 23 | MP0004782_abnormal_surfactant_physiolog | 1.51076421 |
| 24 | MP0010352_gastrointestinal_tract_polyps | 1.47918727 |
| 25 | MP0006035_abnormal_mitochondrial_morpho | 1.45638011 |
| 26 | MP0008058_abnormal_DNA_repair | 1.44966700 |
| 27 | MP0003943_abnormal_hepatobiliary_system | 1.42049609 |
| 28 | MP0000639_abnormal_adrenal_gland | 1.40566522 |
| 29 | MP0002184_abnormal_innervation | 1.37845058 |
| 30 | MP0000358_abnormal_cell_content/ | 1.37569284 |
| 31 | MP0005076_abnormal_cell_differentiation | 1.35054356 |
| 32 | MP0001270_distended_abdomen | 1.33930471 |
| 33 | MP0005365_abnormal_bile_salt | 1.32592660 |
| 34 | MP0004233_abnormal_muscle_weight | 1.30863213 |
| 35 | MP0003937_abnormal_limbs/digits/tail_de | 1.27597910 |
| 36 | MP0009672_abnormal_birth_weight | 1.26863660 |
| 37 | MP0009250_abnormal_appendicular_skeleto | 1.24385551 |
| 38 | MP0002938_white_spotting | 1.23646728 |
| 39 | MP0004858_abnormal_nervous_system | 1.20458899 |
| 40 | MP0005408_hypopigmentation | 1.18145145 |
| 41 | MP0002697_abnormal_eye_size | 1.17755429 |
| 42 | MP0005257_abnormal_intraocular_pressure | 1.17109725 |
| 43 | MP0000467_abnormal_esophagus_morphology | 1.16821855 |
| 44 | MP0009840_abnormal_foam_cell | 1.15728156 |
| 45 | MP0001849_ear_inflammation | 1.14566740 |
| 46 | MP0003566_abnormal_cell_adhesion | 1.14315963 |
| 47 | MP0005666_abnormal_adipose_tissue | 1.14244590 |
| 48 | MP0010368_abnormal_lymphatic_system | 1.14213471 |
| 49 | MP0010329_abnormal_lipoprotein_level | 1.09082143 |
| 50 | MP0000537_abnormal_urethra_morphology | 1.06537186 |
| 51 | MP0001299_abnormal_eye_distance/ | 1.06310913 |
| 52 | MP0003935_abnormal_craniofacial_develop | 1.05191206 |
| 53 | MP0000566_synostosis | 1.03212024 |
| 54 | MP0003942_abnormal_urinary_system | 1.02236912 |
| 55 | MP0005266_abnormal_metabolism | 0.99832372 |
| 56 | MP0002970_abnormal_white_adipose | 0.98465250 |
| 57 | MP0002332_abnormal_exercise_endurance | 0.97289725 |
| 58 | MP0002116_abnormal_craniofacial_bone | 0.95610012 |
| 59 | MP0006138_congestive_heart_failure | 0.94015363 |
| 60 | MP0004185_abnormal_adipocyte_glucose | 0.93897455 |
| 61 | MP0000462_abnormal_digestive_system | 0.93635354 |
| 62 | MP0000678_abnormal_parathyroid_gland | 0.92837704 |
| 63 | MP0000647_abnormal_sebaceous_gland | 0.92730982 |
| 64 | MP0000858_altered_metastatic_potential | 0.92018415 |
| 65 | MP0002282_abnormal_trachea_morphology | 0.90478258 |
| 66 | MP0002249_abnormal_larynx_morphology | 0.88758278 |
| 67 | MP0003879_abnormal_hair_cell | 0.88242245 |
| 68 | MP0003329_amyloid_beta_deposits | 0.87833297 |
| 69 | MP0003868_abnormal_feces_composition | 0.87260555 |
| 70 | MP0004084_abnormal_cardiac_muscle | 0.85774338 |
| 71 | MP0002653_abnormal_ependyma_morphology | 0.84843621 |
| 72 | MP0003303_peritoneal_inflammation | 0.84522806 |
| 73 | MP0004197_abnormal_fetal_growth/weight/ | 0.84243195 |
| 74 | MP0002971_abnormal_brown_adipose | 0.83479293 |
| 75 | MP0003755_abnormal_palate_morphology | 0.81326369 |
| 76 | MP0003948_abnormal_gas_homeostasis | 0.80042675 |
| 77 | MP0005330_cardiomyopathy | 0.78861550 |
| 78 | MP0002111_abnormal_tail_morphology | 0.78246335 |
| 79 | MP0005501_abnormal_skin_physiology | 0.75358822 |
| 80 | MP0001915_intracranial_hemorrhage | 0.74762162 |
| 81 | MP0005623_abnormal_meninges_morphology | 0.74448745 |
| 82 | MP0002113_abnormal_skeleton_development | 0.73892172 |
| 83 | MP0008775_abnormal_heart_ventricle | 0.73748326 |
| 84 | MP0005410_abnormal_fertilization | 0.68305460 |
| 85 | MP0010630_abnormal_cardiac_muscle | 0.68023296 |
| 86 | MP0002115_abnormal_skeleton_extremities | 0.68018251 |
| 87 | MP0000767_abnormal_smooth_muscle | 0.67029778 |
| 88 | MP0002080_prenatal_lethality | 0.66432163 |
| 89 | MP0003632_abnormal_nervous_system | 0.66327022 |
| 90 | MP0001879_abnormal_lymphatic_vessel | 0.65390399 |
| 91 | MP0000681_abnormal_thyroid_gland | 0.65185372 |
| 92 | MP0005332_abnormal_amino_acid | 0.65138060 |
| 93 | MP0004130_abnormal_muscle_cell | 0.64711168 |
| 94 | MP0002086_abnormal_extraembryonic_tissu | 0.63456035 |
| 95 | MP0000534_abnormal_ureter_morphology | 0.63440048 |
| 96 | MP0005384_cellular_phenotype | 0.63110543 |
| 97 | MP0000432_abnormal_head_morphology | 0.63099295 |
| 98 | MP0001340_abnormal_eyelid_morphology | 0.62810744 |
| 99 | MP0001243_abnormal_dermal_layer | 0.62381535 |
| 100 | MP0003698_abnormal_male_reproductive | 0.62040983 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Zonular cataract (HP:0010920) | 5.54734951 |
| 2 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 5.29778805 |
| 3 | Termporal pattern (HP:0011008) | 5.27846278 |
| 4 | Insidious onset (HP:0003587) | 5.27846278 |
| 5 | Ulnar claw (HP:0001178) | 4.97573776 |
| 6 | Upper limb muscle weakness (HP:0003484) | 4.49891293 |
| 7 | Deep venous thrombosis (HP:0002625) | 4.24253944 |
| 8 | Abnormal pupillary function (HP:0007686) | 4.02700107 |
| 9 | Segmental peripheral demyelination/remyelination (HP:0003481) | 3.82164522 |
| 10 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 3.70183207 |
| 11 | Peripheral hypomyelination (HP:0007182) | 3.65335200 |
| 12 | Action tremor (HP:0002345) | 3.64809907 |
| 13 | Progressive hearing impairment (HP:0001730) | 3.49486083 |
| 14 | Hydroxyprolinuria (HP:0003080) | 3.48922406 |
| 15 | Abnormality of proline metabolism (HP:0010907) | 3.48922406 |
| 16 | Progressive sensorineural hearing impairment (HP:0000408) | 3.08410145 |
| 17 | Impaired proprioception (HP:0010831) | 3.01916635 |
| 18 | Gastrointestinal infarctions (HP:0005244) | 2.90508863 |
| 19 | Choreoathetosis (HP:0001266) | 2.85240755 |
| 20 | Poor speech (HP:0002465) | 2.85024741 |
| 21 | Abnormality of the intervertebral disk (HP:0005108) | 2.82442564 |
| 22 | Lissencephaly (HP:0001339) | 2.81682343 |
| 23 | Protrusio acetabuli (HP:0003179) | 2.81368786 |
| 24 | Hypercholesterolemia (HP:0003124) | 2.75718766 |
| 25 | Progressive external ophthalmoplegia (HP:0000590) | 2.73564131 |
| 26 | Premature rupture of membranes (HP:0001788) | 2.73034861 |
| 27 | Flat acetabular roof (HP:0003180) | 2.60272272 |
| 28 | Stridor (HP:0010307) | 2.59338546 |
| 29 | Ragged-red muscle fibers (HP:0003200) | 2.57973787 |
| 30 | Postural tremor (HP:0002174) | 2.55749737 |
| 31 | Nuclear cataract (HP:0100018) | 2.54508254 |
| 32 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.54315435 |
| 33 | Abnormality of homocysteine metabolism (HP:0010919) | 2.49687455 |
| 34 | Homocystinuria (HP:0002156) | 2.49687455 |
| 35 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.42755270 |
| 36 | Brushfield spots (HP:0001088) | 2.40892671 |
| 37 | Broad alveolar ridges (HP:0000187) | 2.40802883 |
| 38 | Abnormality of the astrocytes (HP:0100707) | 2.40227046 |
| 39 | Astrocytoma (HP:0009592) | 2.40227046 |
| 40 | Hammertoe (HP:0001765) | 2.35162840 |
| 41 | Delayed gross motor development (HP:0002194) | 2.30612532 |
| 42 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.26979088 |
| 43 | Limb dystonia (HP:0002451) | 2.24991762 |
| 44 | Ependymoma (HP:0002888) | 2.20377481 |
| 45 | Drooling (HP:0002307) | 2.19615284 |
| 46 | Spinal cord compression (HP:0002176) | 2.17126664 |
| 47 | Heterotopia (HP:0002282) | 2.17084900 |
| 48 | Conjugated hyperbilirubinemia (HP:0002908) | 2.16911434 |
| 49 | Abnormality of lateral ventricle (HP:0030047) | 2.04933130 |
| 50 | Febrile seizures (HP:0002373) | 2.04647891 |
| 51 | Overlapping toe (HP:0001845) | 2.04013736 |
| 52 | Athetosis (HP:0002305) | 2.02898978 |
| 53 | Steppage gait (HP:0003376) | 2.01995663 |
| 54 | Distal sensory impairment (HP:0002936) | 1.99191037 |
| 55 | Thin bony cortex (HP:0002753) | 1.96781898 |
| 56 | Osteomalacia (HP:0002749) | 1.96205802 |
| 57 | Excessive salivation (HP:0003781) | 1.96185650 |
| 58 | Abnormality of the alveolar ridges (HP:0006477) | 1.94358200 |
| 59 | Ulnar bowing (HP:0003031) | 1.93877607 |
| 60 | Upper limb amyotrophy (HP:0009129) | 1.93770136 |
| 61 | Distal upper limb amyotrophy (HP:0007149) | 1.93770136 |
| 62 | Ankle clonus (HP:0011448) | 1.92321465 |
| 63 | Patellar aplasia (HP:0006443) | 1.91730071 |
| 64 | Epidermoid cyst (HP:0200040) | 1.91009497 |
| 65 | Foot dorsiflexor weakness (HP:0009027) | 1.90363244 |
| 66 | Facial hemangioma (HP:0000329) | 1.89647672 |
| 67 | Hypophosphatemic rickets (HP:0004912) | 1.88788624 |
| 68 | Absent hand (HP:0004050) | 1.88136539 |
| 69 | Poikiloderma (HP:0001029) | 1.88018802 |
| 70 | Neonatal death (HP:0003811) | 1.88017829 |
| 71 | Glomerulonephritis (HP:0000099) | 1.87636614 |
| 72 | Hyperacusis (HP:0010780) | 1.87089146 |
| 73 | Onion bulb formation (HP:0003383) | 1.85228805 |
| 74 | Adrenal hypoplasia (HP:0000835) | 1.82306887 |
| 75 | Aplasia involving bones of the extremities (HP:0009825) | 1.82276716 |
| 76 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.82276716 |
| 77 | Aplasia of the phalanges of the hand (HP:0009802) | 1.82276716 |
| 78 | Vertebral compression fractures (HP:0002953) | 1.82142529 |
| 79 | Cerebral aneurysm (HP:0004944) | 1.81929102 |
| 80 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.81647827 |
| 81 | Hand muscle atrophy (HP:0009130) | 1.80670192 |
| 82 | Menorrhagia (HP:0000132) | 1.79552684 |
| 83 | Protruding ear (HP:0000411) | 1.79531523 |
| 84 | Wide intermamillary distance (HP:0006610) | 1.77806354 |
| 85 | Self-mutilation (HP:0000742) | 1.75506996 |
| 86 | Abnormality of carpal bone ossification (HP:0006257) | 1.74267685 |
| 87 | Short tibia (HP:0005736) | 1.73419578 |
| 88 | Abnormality of dentin (HP:0010299) | 1.73001186 |
| 89 | Aneurysm (HP:0002617) | 1.71766225 |
| 90 | Rectal prolapse (HP:0002035) | 1.71468131 |
| 91 | Mucopolysacchariduria (HP:0008155) | 1.68522487 |
| 92 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.68522487 |
| 93 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.68411050 |
| 94 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.68411050 |
| 95 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.68411050 |
| 96 | Aortic regurgitation (HP:0001659) | 1.68346037 |
| 97 | Broad face (HP:0000283) | 1.66866259 |
| 98 | Entropion (HP:0000621) | 1.64720742 |
| 99 | Posterior embryotoxon (HP:0000627) | 1.63394215 |
| 100 | Renal duplication (HP:0000075) | 1.63202029 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SIK2 | 6.60985582 |
| 2 | ICK | 4.75130833 |
| 3 | NEK2 | 3.91681683 |
| 4 | TRIB3 | 3.73300020 |
| 5 | TAOK3 | 3.58770653 |
| 6 | MST1R | 3.26236709 |
| 7 | EPHA4 | 2.72903891 |
| 8 | EEF2K | 2.67808242 |
| 9 | FGFR4 | 2.64088624 |
| 10 | PKN2 | 2.47987044 |
| 11 | TESK1 | 2.20715903 |
| 12 | MINK1 | 1.95606562 |
| 13 | MET | 1.95164098 |
| 14 | IRAK3 | 1.77277790 |
| 15 | PTK2 | 1.64465709 |
| 16 | MAP3K13 | 1.61364603 |
| 17 | SIK1 | 1.59805949 |
| 18 | EPHA2 | 1.47375514 |
| 19 | NTRK3 | 1.34422014 |
| 20 | LIMK1 | 1.33119027 |
| 21 | PRKCI | 1.28711466 |
| 22 | FLT3 | 1.21501923 |
| 23 | MATK | 1.16605826 |
| 24 | CDK7 | 1.14669243 |
| 25 | RPS6KB2 | 1.13801090 |
| 26 | PDGFRA | 1.12268298 |
| 27 | RPS6KA5 | 1.09184353 |
| 28 | RPS6KA4 | 1.04753200 |
| 29 | RIPK1 | 1.02902317 |
| 30 | NME2 | 1.02474026 |
| 31 | CDK12 | 0.91701528 |
| 32 | BRSK1 | 0.85037788 |
| 33 | ERN1 | 0.84372880 |
| 34 | LATS2 | 0.83911659 |
| 35 | MAP3K14 | 0.83557710 |
| 36 | TGFBR2 | 0.82221672 |
| 37 | PIM2 | 0.79878673 |
| 38 | MTOR | 0.79873800 |
| 39 | RPS6KA2 | 0.74259264 |
| 40 | DAPK2 | 0.73895562 |
| 41 | PAK4 | 0.71847588 |
| 42 | PRKAA2 | 0.69973979 |
| 43 | CAMKK1 | 0.69526395 |
| 44 | KIT | 0.69104529 |
| 45 | CDK8 | 0.67729921 |
| 46 | MAP2K6 | 0.66837742 |
| 47 | ERBB4 | 0.66560300 |
| 48 | TTN | 0.64542897 |
| 49 | NTRK1 | 0.62237334 |
| 50 | CHEK1 | 0.60240440 |
| 51 | MAPK8 | 0.57063882 |
| 52 | BRSK2 | 0.56411513 |
| 53 | FGFR3 | 0.55755813 |
| 54 | CAMK2A | 0.52160519 |
| 55 | CHUK | 0.52022881 |
| 56 | MOS | 0.51941466 |
| 57 | CDC42BPA | 0.48597345 |
| 58 | MAPK11 | 0.48449760 |
| 59 | STK39 | 0.48191747 |
| 60 | CDK14 | 0.48074270 |
| 61 | BMX | 0.47306356 |
| 62 | PDK2 | 0.46927231 |
| 63 | EIF2AK3 | 0.45799430 |
| 64 | MAP3K7 | 0.45294722 |
| 65 | MAPK10 | 0.45217325 |
| 66 | MAPKAPK3 | 0.44842921 |
| 67 | PRKCG | 0.44716949 |
| 68 | CDK15 | 0.44299165 |
| 69 | TYRO3 | 0.44217256 |
| 70 | RPS6KC1 | 0.42667288 |
| 71 | RPS6KL1 | 0.42667288 |
| 72 | RPS6KB1 | 0.42498184 |
| 73 | SRPK1 | 0.42293253 |
| 74 | LMTK2 | 0.41803520 |
| 75 | CDK1 | 0.41530717 |
| 76 | RPS6KA1 | 0.40367442 |
| 77 | CDK18 | 0.40283604 |
| 78 | ILK | 0.40250936 |
| 79 | FGFR1 | 0.39930035 |
| 80 | CDK4 | 0.39724123 |
| 81 | PTK6 | 0.39216584 |
| 82 | RPS6KA6 | 0.36945432 |
| 83 | MAPK1 | 0.35516378 |
| 84 | CDK11A | 0.34996598 |
| 85 | EIF2AK1 | 0.34730377 |
| 86 | ARAF | 0.33907361 |
| 87 | TESK2 | 0.32823613 |
| 88 | MARK2 | 0.32339869 |
| 89 | CSNK1A1 | 0.32084710 |
| 90 | MKNK2 | 0.31721484 |
| 91 | RAF1 | 0.31682685 |
| 92 | CAMK2B | 0.31069855 |
| 93 | MELK | 0.30327647 |
| 94 | DDR2 | 0.30279782 |
| 95 | CAMK2D | 0.30229071 |
| 96 | RET | 0.29307798 |
| 97 | PRKAA1 | 0.28951675 |
| 98 | PRKG2 | 0.27275972 |
| 99 | GSK3B | 0.27239935 |
| 100 | CSNK2A2 | 0.26083724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ABC transporters_Homo sapiens_hsa02010 | 3.80247393 |
| 2 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.25434364 |
| 3 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.62487813 |
| 4 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.49231604 |
| 5 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.35845481 |
| 6 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.29875910 |
| 7 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.13585995 |
| 8 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.07067924 |
| 9 | Other glycan degradation_Homo sapiens_hsa00511 | 2.06539008 |
| 10 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.02311131 |
| 11 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 2.00612716 |
| 12 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.80238720 |
| 13 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.79617129 |
| 14 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.76086597 |
| 15 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.73514994 |
| 16 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.62616942 |
| 17 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.60257669 |
| 18 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.59194338 |
| 19 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.56460520 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.55930076 |
| 21 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.54763772 |
| 22 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.45894796 |
| 23 | Histidine metabolism_Homo sapiens_hsa00340 | 1.32127560 |
| 24 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.30947899 |
| 25 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.22608763 |
| 26 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.21004767 |
| 27 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.19811921 |
| 28 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.16535518 |
| 29 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.11238488 |
| 30 | Bladder cancer_Homo sapiens_hsa05219 | 1.09519131 |
| 31 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.01891598 |
| 32 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.01305591 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.01274461 |
| 34 | Focal adhesion_Homo sapiens_hsa04510 | 1.00746328 |
| 35 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.96408897 |
| 36 | Shigellosis_Homo sapiens_hsa05131 | 0.93876554 |
| 37 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.93838680 |
| 38 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.89451085 |
| 39 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.89360663 |
| 40 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.85842239 |
| 41 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.84457652 |
| 42 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.83365865 |
| 43 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.83079951 |
| 44 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.82506157 |
| 45 | Bile secretion_Homo sapiens_hsa04976 | 0.81812908 |
| 46 | Base excision repair_Homo sapiens_hsa03410 | 0.81290749 |
| 47 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.80244607 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 0.78347314 |
| 49 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.75212045 |
| 50 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.74493797 |
| 51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.73947963 |
| 52 | Adherens junction_Homo sapiens_hsa04520 | 0.71567981 |
| 53 | Galactose metabolism_Homo sapiens_hsa00052 | 0.70902027 |
| 54 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.70807149 |
| 55 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.69833169 |
| 56 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.69494893 |
| 57 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.69336885 |
| 58 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.68207227 |
| 59 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.67871452 |
| 60 | Insulin resistance_Homo sapiens_hsa04931 | 0.66074397 |
| 61 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.65691793 |
| 62 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.64826298 |
| 63 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.64159039 |
| 64 | DNA replication_Homo sapiens_hsa03030 | 0.63224166 |
| 65 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.61267672 |
| 66 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.58072664 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.55160536 |
| 68 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.54591758 |
| 69 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.53941678 |
| 70 | Cell cycle_Homo sapiens_hsa04110 | 0.53619632 |
| 71 | Legionellosis_Homo sapiens_hsa05134 | 0.53445589 |
| 72 | Lysosome_Homo sapiens_hsa04142 | 0.53034881 |
| 73 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.52921925 |
| 74 | Cocaine addiction_Homo sapiens_hsa05030 | 0.52165551 |
| 75 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.49936303 |
| 76 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.49692394 |
| 77 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.48894601 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.48423562 |
| 79 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.47510138 |
| 80 | Endocytosis_Homo sapiens_hsa04144 | 0.47317531 |
| 81 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.46594267 |
| 82 | GABAergic synapse_Homo sapiens_hsa04727 | 0.45733709 |
| 83 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.45295301 |
| 84 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.45095704 |
| 85 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.44864773 |
| 86 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.44548946 |
| 87 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.44442390 |
| 88 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.40365217 |
| 89 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.39100176 |
| 90 | Amoebiasis_Homo sapiens_hsa05146 | 0.37579550 |
| 91 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.37409545 |
| 92 | Salmonella infection_Homo sapiens_hsa05132 | 0.37292710 |
| 93 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.35302351 |
| 94 | Salivary secretion_Homo sapiens_hsa04970 | 0.34904238 |
| 95 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.34734179 |
| 96 | Alcoholism_Homo sapiens_hsa05034 | 0.34627817 |
| 97 | Axon guidance_Homo sapiens_hsa04360 | 0.33956170 |
| 98 | Morphine addiction_Homo sapiens_hsa05032 | 0.33901009 |
| 99 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.33707909 |
| 100 | RNA transport_Homo sapiens_hsa03013 | 0.33259534 |

