DUSP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.24461625
2endothelium development (GO:0003158)5.08877995
3germ cell migration (GO:0008354)4.71698181
4establishment of integrated proviral latency (GO:0075713)4.46628857
5DNA double-strand break processing (GO:0000729)4.21341199
6establishment of viral latency (GO:0019043)4.05790686
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.97110826
8regulation of mitotic spindle checkpoint (GO:1903504)3.97110826
9regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.95731160
10cellular response to fluid shear stress (GO:0071498)3.95489891
11neutrophil activation involved in immune response (GO:0002283)3.83338743
12Notch signaling involved in heart development (GO:0061314)3.79376974
13monocyte differentiation (GO:0030224)3.69950770
14response to peptidoglycan (GO:0032494)3.65671699
15microglial cell activation (GO:0001774)3.61642510
16morphogenesis of an endothelium (GO:0003159)3.60894884
17endothelial tube morphogenesis (GO:0061154)3.60894884
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60364323
19histamine secretion (GO:0001821)3.56407339
20hepatocyte apoptotic process (GO:0097284)3.52772515
21vascular endothelial growth factor signaling pathway (GO:0038084)3.51962540
22membrane invagination (GO:0010324)3.51584801
23leukocyte migration involved in inflammatory response (GO:0002523)3.47747174
24branch elongation of an epithelium (GO:0060602)3.44798628
25epithelial cell differentiation involved in kidney development (GO:0035850)3.44348860
26response to X-ray (GO:0010165)3.43012931
27negative regulation of granulocyte differentiation (GO:0030853)3.42889901
28cellular glucuronidation (GO:0052695)3.38371843
29response to fluid shear stress (GO:0034405)3.33421036
30definitive hemopoiesis (GO:0060216)3.32538152
31chromatin remodeling at centromere (GO:0031055)3.30007836
32response to laminar fluid shear stress (GO:0034616)3.27479770
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.27363327
34regulation of endothelial cell differentiation (GO:0045601)3.25838506
35blood vessel endothelial cell migration (GO:0043534)3.20970682
36CENP-A containing nucleosome assembly (GO:0034080)3.20366424
37macrophage activation (GO:0042116)3.14946330
38surfactant homeostasis (GO:0043129)3.14112985
39cellular extravasation (GO:0045123)3.13316736
40mitotic G2/M transition checkpoint (GO:0044818)3.12150809
41positive regulation of vasculogenesis (GO:2001214)3.10778565
42uronic acid metabolic process (GO:0006063)3.08958375
43glucuronate metabolic process (GO:0019585)3.08958375
44embryonic process involved in female pregnancy (GO:0060136)3.05990068
45negative regulation of phagocytosis (GO:0050765)3.05940008
46negative regulation of cell fate specification (GO:0009996)3.04963370
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04295505
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04295505
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04295505
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.04295505
51negative regulation of sister chromatid segregation (GO:0033046)3.04295505
52patterning of blood vessels (GO:0001569)3.03052712
53angiogenesis involved in wound healing (GO:0060055)3.01607511
54regulation of chemokine secretion (GO:0090196)3.01420079
55cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.00897346
56regulation of vasculogenesis (GO:2001212)2.98955919
57outer ear morphogenesis (GO:0042473)2.98927409
58regulation of telomere maintenance via telomerase (GO:0032210)2.98514901
59positive regulation by symbiont of host defense response (GO:0052509)2.98228512
60modulation by symbiont of host defense response (GO:0052031)2.98228512
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98228512
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98228512
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.98228512
64modulation by symbiont of host immune response (GO:0052553)2.98228512
65positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98048170
66positive regulation of cardiac muscle cell differentiation (GO:2000727)2.95041690
67regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94497638
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94497638
69negative regulation of DNA recombination (GO:0045910)2.92271304
70regulation of mononuclear cell migration (GO:0071675)2.90547900
71mitotic G2 DNA damage checkpoint (GO:0007095)2.90107051
72protein deneddylation (GO:0000338)2.89718791
73DNA replication-independent nucleosome organization (GO:0034724)2.88837549
74DNA replication-independent nucleosome assembly (GO:0006336)2.88837549
75IMP biosynthetic process (GO:0006188)2.88631457
76positive regulation of endothelial cell differentiation (GO:0045603)2.88463961
77cell adhesion mediated by integrin (GO:0033627)2.88402538
78lymphangiogenesis (GO:0001946)2.87969782
79negative regulation of thymocyte apoptotic process (GO:0070244)2.87945227
80regulation of mesoderm development (GO:2000380)2.87116205
81endothelial cell morphogenesis (GO:0001886)2.87023896
82negative regulation of chromosome segregation (GO:0051985)2.86684337
83endoderm formation (GO:0001706)2.86558408
84negative regulation of smooth muscle cell migration (GO:0014912)2.85639199
85regulation of B cell receptor signaling pathway (GO:0050855)2.85618098
86negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81968130
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.81968130
88regulation of translation, ncRNA-mediated (GO:0045974)2.81968130
89sialylation (GO:0097503)2.81568675
90positive regulation of interleukin-8 secretion (GO:2000484)2.80633569
91regulation of SMAD protein import into nucleus (GO:0060390)2.80308217
92histone exchange (GO:0043486)2.77978645
93mammary gland epithelial cell proliferation (GO:0033598)2.77929099
94platelet dense granule organization (GO:0060155)2.76814620
95positive regulation of cellular amide metabolic process (GO:0034250)2.76253204
96glycosphingolipid biosynthetic process (GO:0006688)2.75990544
97phagocytosis, engulfment (GO:0006911)2.74578926
98purine nucleobase biosynthetic process (GO:0009113)2.71959408
99cullin deneddylation (GO:0010388)2.70821210
100regulation of interleukin-8 biosynthetic process (GO:0045414)2.70819967
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70760563
102regulation of secondary heart field cardioblast proliferation (GO:0003266)2.70270438
103regulation of cardioblast proliferation (GO:0003264)2.70270438
104cell migration involved in sprouting angiogenesis (GO:0002042)2.70053266
105mitotic spindle checkpoint (GO:0071174)2.69209581
106regulation of mitotic sister chromatid separation (GO:0010965)2.69165473
107regulation of mitotic sister chromatid segregation (GO:0033047)2.69165473
108regulation of sister chromatid segregation (GO:0033045)2.69165473
109germinal center formation (GO:0002467)2.69090322
110detection of molecule of bacterial origin (GO:0032490)2.67742757
111bone remodeling (GO:0046849)2.66537061
112DNA catabolic process, exonucleolytic (GO:0000738)2.66414763
113negative regulation of interleukin-1 beta production (GO:0032691)2.65808699
114macrophage differentiation (GO:0030225)2.65785515
115negative regulation of interleukin-1 production (GO:0032692)2.65335243
116spindle checkpoint (GO:0031577)2.65240480
117DNA ligation (GO:0006266)2.64578386
118axon extension involved in axon guidance (GO:0048846)2.64272478
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.64272478
120substrate-dependent cell migration (GO:0006929)2.63266458
121positive regulation of epithelial to mesenchymal transition (GO:0010718)2.62599038
122heart field specification (GO:0003128)2.61869281
123secondary heart field specification (GO:0003139)2.61869281
124chemical homeostasis within a tissue (GO:0048875)2.61686875
125mRNA transcription from RNA polymerase II promoter (GO:0042789)2.60596625
126detection of other organism (GO:0098543)2.59531056
127positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58847934
128hemidesmosome assembly (GO:0031581)2.58010536
129endothelial cell differentiation (GO:0045446)2.57690796
130IMP metabolic process (GO:0046040)2.57348502
131mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57235004
132neutrophil mediated immunity (GO:0002446)2.57123581
133neutrophil activation (GO:0042119)2.56939607
134negative regulation of protein autophosphorylation (GO:0031953)2.56684899
135heart valve morphogenesis (GO:0003179)2.56360757
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56270749
137* regulation of gastrulation (GO:0010470)2.54521267
138histamine transport (GO:0051608)2.53991350
139axis elongation (GO:0003401)2.53758619
140positive regulation of SMAD protein import into nucleus (GO:0060391)2.53172291
141regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.52684142
142mesodermal cell differentiation (GO:0048333)2.52428095
143positive regulation of chemokine secretion (GO:0090197)2.51761842
144mitotic spindle assembly checkpoint (GO:0007094)2.51305829
145cell surface receptor signaling pathway involved in heart development (GO:0061311)2.51232351
146positive regulation of interferon-beta production (GO:0032728)2.51191516
147facial nerve structural organization (GO:0021612)2.51175890
148cartilage morphogenesis (GO:0060536)2.50506820
149response to folic acid (GO:0051593)2.49931419
150response to xenobiotic stimulus (GO:0009410)2.48989733
151response to muramyl dipeptide (GO:0032495)2.48533027
152vasculogenesis (GO:0001570)2.48458156
153DNA replication-dependent nucleosome assembly (GO:0006335)2.47171126
154DNA replication-dependent nucleosome organization (GO:0034723)2.47171126
155lung lobe morphogenesis (GO:0060463)2.47111058
156cell proliferation involved in kidney development (GO:0072111)2.46266083
157positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.45707226
158regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.45707226
159positive regulation of male gonad development (GO:2000020)2.45679593
160sprouting angiogenesis (GO:0002040)2.45325451
161blood vessel remodeling (GO:0001974)2.44947578
162blood vessel maturation (GO:0001955)2.44333824
163regulation of helicase activity (GO:0051095)2.44231734
164Notch receptor processing (GO:0007220)2.43977706
165spindle assembly checkpoint (GO:0071173)2.43856236
166protein localization to kinetochore (GO:0034501)2.43419260
167dendritic cell migration (GO:0036336)2.43178742
168neutrophil chemotaxis (GO:0030593)2.42431955
169osteoclast differentiation (GO:0030316)2.42360374
170negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41856329
171attachment of spindle microtubules to kinetochore (GO:0008608)2.41706610
172renal filtration (GO:0097205)2.41655216
173negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.41271572
174regulation of interferon-beta biosynthetic process (GO:0045357)2.41166281
175embryonic viscerocranium morphogenesis (GO:0048703)2.40877205
176negative regulation of meiosis (GO:0045835)2.39827616
177response to vitamin E (GO:0033197)2.39734297
178positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.39684251
179negative regulation of systemic arterial blood pressure (GO:0003085)2.39330304
180granulocyte activation (GO:0036230)2.39186006
181macrophage activation involved in immune response (GO:0002281)2.38878087
182positive regulation of myoblast differentiation (GO:0045663)2.38494147
183branching involved in salivary gland morphogenesis (GO:0060445)2.37923204
184negative regulation of mitosis (GO:0045839)2.37862453
185organ formation (GO:0048645)2.37612024
186metaphase plate congression (GO:0051310)2.37418876
187response to increased oxygen levels (GO:0036296)2.36977444
188response to hyperoxia (GO:0055093)2.36977444
189trabecula morphogenesis (GO:0061383)2.36828983
190basement membrane organization (GO:0071711)2.36589631
191face development (GO:0060324)2.36237015
192positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.35062744
193positive regulation of protein homodimerization activity (GO:0090073)2.35008225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.96821039
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.57790262
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.79750179
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.22280566
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09038645
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.91064846
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.86153073
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.92872227
9CLOCK_20551151_ChIP-Seq_293T_Human2.80226136
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.79462312
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76840736
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.66691220
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63712147
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61236935
15ELK1_19687146_ChIP-ChIP_HELA_Human2.53810235
16* WT1_19549856_ChIP-ChIP_CCG9911_Human2.53564010
17* CDX2_20551321_ChIP-Seq_CACO-2_Human2.39665820
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37833963
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.37746141
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.33401291
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.30866234
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30131214
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26087930
24ZNF274_21170338_ChIP-Seq_K562_Hela2.22011802
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19086685
26GATA2_21666600_ChIP-Seq_HMVEC_Human2.14088041
27* RUNX_20019798_ChIP-Seq_JUKART_Human2.11454055
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.04714409
29SCL_19346495_ChIP-Seq_HPC-7_Human2.03762844
30* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01564768
31* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97683408
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96644683
33E2F7_22180533_ChIP-Seq_HELA_Human1.95094540
34* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87715541
35* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87715541
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85690240
37* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84341884
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82729025
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77614367
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77494934
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75930706
42* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74693465
43* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72734617
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71037260
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.70494719
46VDR_22108803_ChIP-Seq_LS180_Human1.68522676
47VDR_24787735_ChIP-Seq_THP-1_Human1.67885539
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.65925986
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65672436
50* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65376562
51TAF15_26573619_Chip-Seq_HEK293_Human1.64545166
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64352439
53* P300_19829295_ChIP-Seq_ESCs_Human1.63292415
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63119968
55* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62516674
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60026466
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60026466
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60026466
59* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56630458
60* NANOG_16153702_ChIP-ChIP_HESCs_Human1.55835859
61* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54303037
62* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53007039
63* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52193147
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.51621214
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50922730
66* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48483008
67TP53_18474530_ChIP-ChIP_U2OS_Human1.47249799
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45970540
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.44720774
70* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.44510879
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44013225
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42753810
73VDR_23849224_ChIP-Seq_CD4+_Human1.42650585
74* TCF7_22412390_ChIP-Seq_EML_Mouse1.42236725
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39777638
76* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39229864
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38671180
78AHR_22903824_ChIP-Seq_MCF-7_Human1.32269493
79AR_21909140_ChIP-Seq_LNCAP_Human1.31392883
80BRD4_25478319_ChIP-Seq_HGPS_Human1.31335153
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31074264
82* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30468192
83* FUS_26573619_Chip-Seq_HEK293_Human1.30153606
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29156342
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27875650
86CJUN_26792858_Chip-Seq_BT549_Human1.26979284
87* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26256364
88SOX2_20726797_ChIP-Seq_SW620_Human1.25976422
89* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25460582
90EWS_26573619_Chip-Seq_HEK293_Human1.25371999
91MYC_22102868_ChIP-Seq_BL_Human1.24079438
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.23583207
93* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23062094
94* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22980553
95* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22014605
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.20822869
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20424922
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19508682
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18561747
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18352420
101* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17293786
102* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17261903
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17237125
104* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16876965
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16587861
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16233647
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15055090
108FOXP3_21729870_ChIP-Seq_TREG_Human1.14318843
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12553632
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12018120
111ELK1_22589737_ChIP-Seq_MCF10A_Human1.11834547
112* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10673057
113ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10544649
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.10310709
115VDR_24763502_ChIP-Seq_THP-1_Human1.09305784
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09102176
117* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08601388
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.08565876
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08071786
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05362679
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.04516969
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02894154
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02659007
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02627281
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02354355
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01702413
127* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01620423
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01617651
129* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01551755
130TP53_16413492_ChIP-PET_HCT116_Human1.00461425
131ZNF263_19887448_ChIP-Seq_K562_Human1.00016011
132* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99670511
133* PU_27001747_Chip-Seq_BMDM_Mouse0.99466690
134* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98543689
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97073549
136* MYB_26560356_Chip-Seq_TH2_Human0.96995711
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95932477
138PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94452391
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93843042
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.93602624
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.93192742
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91935498
143MYC_18940864_ChIP-ChIP_HL60_Human0.91751287
144* MAF_26560356_Chip-Seq_TH1_Human0.90862129
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90826570
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90826570
147* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90801734
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90133081
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89693310
150* IRF1_19129219_ChIP-ChIP_H3396_Human0.89548035
151IGF1R_20145208_ChIP-Seq_DFB_Human0.88791909
152* SOX2_16153702_ChIP-ChIP_HESCs_Human0.87789856
153* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86641746
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85857284
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84317607
156* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84051183
157* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84034515
158* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83688528
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83459205
160SRF_21415370_ChIP-Seq_HL-1_Mouse0.83385789
161* EZH2_27294783_Chip-Seq_NPCs_Mouse0.83338980
162* SPI1_23547873_ChIP-Seq_NB4_Human0.81669450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.33050656
2MP0001879_abnormal_lymphatic_vessel3.05521482
3MP0010234_abnormal_vibrissa_follicle2.95889676
4MP0004272_abnormal_basement_membrane2.73066070
5MP0003300_gastrointestinal_ulcer2.49658870
6MP0006054_spinal_hemorrhage2.38519409
7MP0004883_abnormal_blood_vessel2.36101411
8MP0005167_abnormal_blood-brain_barrier2.34924532
9MP0003724_increased_susceptibility_to2.34162398
10MP0001293_anophthalmia2.13235697
11MP0001915_intracranial_hemorrhage2.12908350
12MP0004808_abnormal_hematopoietic_stem2.11213046
13MP0009278_abnormal_bone_marrow2.08538530
14MP0003279_aneurysm2.08427040
15MP0003191_abnormal_cellular_cholesterol2.03171904
16MP0006292_abnormal_olfactory_placode2.02972479
17MP0002653_abnormal_ependyma_morphology2.01682652
18MP0002254_reproductive_system_inflammat1.99890279
19MP0009379_abnormal_foot_pigmentation1.97957437
20MP0010094_abnormal_chromosome_stability1.91324782
21MP0000465_gastrointestinal_hemorrhage1.89347370
22MP0008058_abnormal_DNA_repair1.87681907
23MP0000767_abnormal_smooth_muscle1.87552620
24MP0002396_abnormal_hematopoietic_system1.86936429
25MP0002166_altered_tumor_susceptibility1.81528649
26MP0009764_decreased_sensitivity_to1.77323004
27MP0000383_abnormal_hair_follicle1.73943159
28MP0002009_preneoplasia1.73705042
29MP0003122_maternal_imprinting1.73091187
30MP0003566_abnormal_cell_adhesion1.71981821
31MP0005171_absent_coat_pigmentation1.70684888
32MP0003943_abnormal_hepatobiliary_system1.68644322
33MP0003436_decreased_susceptibility_to1.68492943
34MP0003890_abnormal_embryonic-extraembry1.66768450
35MP0008007_abnormal_cellular_replicative1.64541174
36MP0003303_peritoneal_inflammation1.62713972
37MP0005164_abnormal_response_to1.58100473
38MP0010352_gastrointestinal_tract_polyps1.57923706
39MP0003828_pulmonary_edema1.55027222
40MP0001545_abnormal_hematopoietic_system1.54913160
41MP0005397_hematopoietic_system_phenotyp1.54913160
42MP0003195_calcinosis1.53105613
43MP0010678_abnormal_skin_adnexa1.51511848
44MP0005084_abnormal_gallbladder_morpholo1.50267257
45MP0003221_abnormal_cardiomyocyte_apopto1.49406540
46MP0005408_hypopigmentation1.45463888
47MP0000858_altered_metastatic_potential1.44226274
48MP0008260_abnormal_autophagy1.42326340
49MP0005623_abnormal_meninges_morphology1.42233629
50MP0008932_abnormal_embryonic_tissue1.42051527
51MP0005023_abnormal_wound_healing1.40780201
52MP0006082_CNS_inflammation1.40057096
53MP0000249_abnormal_blood_vessel1.39683957
54MP0003091_abnormal_cell_migration1.38439960
55MP0003121_genomic_imprinting1.38241621
56MP0005248_abnormal_Harderian_gland1.37825011
57MP0009053_abnormal_anal_canal1.37570342
58MP0005464_abnormal_platelet_physiology1.34380734
59MP0002933_joint_inflammation1.32082804
60MP0002419_abnormal_innate_immunity1.30994278
61MP0002282_abnormal_trachea_morphology1.30622375
62MP0001188_hyperpigmentation1.28342072
63MP0003693_abnormal_embryo_hatching1.26198990
64MP0004133_heterotaxia1.24671305
65MP0010307_abnormal_tumor_latency1.23826208
66MP0003453_abnormal_keratinocyte_physiol1.22598228
67MP0003705_abnormal_hypodermis_morpholog1.22546264
68MP0006072_abnormal_retinal_apoptosis1.21652995
69MP0001533_abnormal_skeleton_physiology1.19946050
70MP0003077_abnormal_cell_cycle1.17797102
71MP0005025_abnormal_response_to1.17555791
72MP0009384_cardiac_valve_regurgitation1.15996016
73* MP0002925_abnormal_cardiovascular_devel1.12733986
74MP0005367_renal/urinary_system_phenotyp1.12471049
75MP0000516_abnormal_urinary_system1.12471049
76MP0002405_respiratory_system_inflammati1.11931161
77* MP0000343_altered_response_to1.11766881
78MP0000733_abnormal_muscle_development1.11563938
79MP0002006_tumorigenesis1.10953337
80MP0001324_abnormal_eye_pigmentation1.10519503
81MP0002928_abnormal_bile_duct1.09768254
82MP0008789_abnormal_olfactory_epithelium1.09379775
83MP0003075_altered_response_to1.07483377
84MP0004782_abnormal_surfactant_physiolog1.06242421
85MP0001614_abnormal_blood_vessel1.06186702
86MP0001286_abnormal_eye_development1.06002044
87MP0001835_abnormal_antigen_presentation1.04984638
88MP0005076_abnormal_cell_differentiation1.02759193
89MP0003941_abnormal_skin_development1.01865702
90MP0002452_abnormal_antigen_presenting1.01593280
91MP0002723_abnormal_immune_serum1.00591809
92MP0001853_heart_inflammation1.00109263
93MP0001851_eye_inflammation0.99528455
94MP0005377_hearing/vestibular/ear_phenot0.97692912
95MP0003878_abnormal_ear_physiology0.97692912
96MP0010329_abnormal_lipoprotein_level0.97214574
97MP0003111_abnormal_nucleus_morphology0.95318043
98MP0002249_abnormal_larynx_morphology0.95259838
99MP0000647_abnormal_sebaceous_gland0.94668260
100MP0002877_abnormal_melanocyte_morpholog0.93857133
101MP0009785_altered_susceptibility_to0.93671371
102MP0005671_abnormal_response_to0.93424197
103MP0002102_abnormal_ear_morphology0.93303151
104MP0000372_irregular_coat_pigmentation0.92878436
105MP0008877_abnormal_DNA_methylation0.91891428
106MP0005000_abnormal_immune_tolerance0.91718108
107MP0003638_abnormal_response/metabolism_0.91337126
108MP0002133_abnormal_respiratory_system0.89576955
109MP0005388_respiratory_system_phenotype0.89576955
110MP0005390_skeleton_phenotype0.89172712
111MP0000762_abnormal_tongue_morphology0.89117694
112* MP0005166_decreased_susceptibility_to0.88449923
113MP0009697_abnormal_copulation0.88342410
114MP0002132_abnormal_respiratory_system0.87978186
115MP0003937_abnormal_limbs/digits/tail_de0.87694487
116MP0002233_abnormal_nose_morphology0.87558690
117MP0009840_abnormal_foam_cell0.86759311
118MP0010155_abnormal_intestine_physiology0.85903784
119MP0002128_abnormal_blood_circulation0.84240819
120MP0003448_altered_tumor_morphology0.83222795
121MP0002998_abnormal_bone_remodeling0.82684928
122MP0001191_abnormal_skin_condition0.82191138
123MP0002138_abnormal_hepatobiliary_system0.82003036
124MP0005085_abnormal_gallbladder_physiolo0.81921322
125MP0010030_abnormal_orbit_morphology0.81769459
126MP0004957_abnormal_blastocyst_morpholog0.80629075
127MP0003567_abnormal_fetal_cardiomyocyte0.80496059
128MP0003942_abnormal_urinary_system0.80091450
129MP0002420_abnormal_adaptive_immunity0.80020941
130MP0009765_abnormal_xenobiotic_induced0.79904516
131MP0002148_abnormal_hypersensitivity_rea0.79076910
132MP0008057_abnormal_DNA_replication0.78841090
133MP0008873_increased_physiological_sensi0.78602553
134MP0002111_abnormal_tail_morphology0.78086056
135MP0004264_abnormal_extraembryonic_tissu0.77731516
136MP0001819_abnormal_immune_cell0.77682399
137* MP0000689_abnormal_spleen_morphology0.77151795
138MP0002086_abnormal_extraembryonic_tissu0.77040529
139MP0005253_abnormal_eye_physiology0.76841255
140MP0005165_increased_susceptibility_to0.75948902
141MP0006138_congestive_heart_failure0.74745556
142MP0001800_abnormal_humoral_immune0.74409205
143MP0005197_abnormal_uvea_morphology0.74403950
144MP0003984_embryonic_growth_retardation0.73459768
145MP0003806_abnormal_nucleotide_metabolis0.73158224
146MP0003119_abnormal_digestive_system0.72796673
147MP0001672_abnormal_embryogenesis/_devel0.72247400
148MP0005380_embryogenesis_phenotype0.72247400
149MP0002751_abnormal_autonomic_nervous0.72145431
150MP0008469_abnormal_protein_level0.71603635

Predicted human phenotypes

RankGene SetZ-score
1Urethral obstruction (HP:0000796)5.58450454
2Systemic lupus erythematosus (HP:0002725)4.72716518
3Hematochezia (HP:0002573)4.72472849
4Colon cancer (HP:0003003)4.48892690
5Glomerulonephritis (HP:0000099)3.88308031
6Vascular tortuosity (HP:0004948)3.70461341
7Arterial tortuosity (HP:0005116)3.66420753
8Subacute progressive viral hepatitis (HP:0006572)3.44795983
9Exercise-induced muscle cramps (HP:0003710)3.39962237
10Myocardial infarction (HP:0001658)3.33679744
11Eczematoid dermatitis (HP:0000976)3.33261000
12Spastic diplegia (HP:0001264)3.32909081
13Asymmetry of the thorax (HP:0001555)3.16132305
14Nephritis (HP:0000123)3.13278246
15Complement deficiency (HP:0004431)3.10815336
16Stomatitis (HP:0010280)3.04609288
17Pancreatic islet-cell hyperplasia (HP:0004510)2.98848958
18Spontaneous hematomas (HP:0007420)2.96685573
19Orchitis (HP:0100796)2.94579227
20Meckel diverticulum (HP:0002245)2.93558232
21Onycholysis (HP:0001806)2.91174061
22Esophageal varix (HP:0002040)2.88556735
23Mediastinal lymphadenopathy (HP:0100721)2.88094719
24True hermaphroditism (HP:0010459)2.87866798
25Aortic aneurysm (HP:0004942)2.86942101
26Amyloidosis (HP:0011034)2.86878149
27* Breast aplasia (HP:0100783)2.86207313
28Cortical dysplasia (HP:0002539)2.86202792
29Rhabdomyosarcoma (HP:0002859)2.83045324
30Bilateral sensorineural hearing impairment (HP:0008619)2.82933012
31Prostate neoplasm (HP:0100787)2.82368140
32Abolished electroretinogram (ERG) (HP:0000550)2.81454198
33* Aplasia/Hypoplasia of the breasts (HP:0010311)2.80554895
34Cerebral aneurysm (HP:0004944)2.80142732
35Abnormality of the ileum (HP:0001549)2.78162225
36Optic neuritis (HP:0100653)2.77777883
37Retrobulbar optic neuritis (HP:0100654)2.77777883
38Septo-optic dysplasia (HP:0100842)2.75605243
39Abnormality of complement system (HP:0005339)2.75073350
40Milia (HP:0001056)2.75064916
41Elevated erythrocyte sedimentation rate (HP:0003565)2.73074024
42Abnormality of chromosome stability (HP:0003220)2.71768079
43Heterochromia iridis (HP:0001100)2.69673757
44Abnormal lung lobation (HP:0002101)2.65380617
45Hydroureter (HP:0000072)2.65199540
46Alveolar cell carcinoma (HP:0006519)2.63342547
47Stenosis of the external auditory canal (HP:0000402)2.62749445
48Distal lower limb muscle weakness (HP:0009053)2.62642483
49Postnatal microcephaly (HP:0005484)2.57717572
50Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.45768397
51Aplasia cutis congenita (HP:0001057)2.45140515
52Agnosia (HP:0010524)2.44167068
53Supernumerary spleens (HP:0009799)2.43734634
54Abnormality of macrophages (HP:0004311)2.41757212
55Upper motor neuron abnormality (HP:0002127)2.41727988
56Choroideremia (HP:0001139)2.40818040
57Micronodular cirrhosis (HP:0001413)2.39510107
58Epidermoid cyst (HP:0200040)2.38213289
59Bicuspid aortic valve (HP:0001647)2.35506060
60Keratoconjunctivitis sicca (HP:0001097)2.33128074
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.31498576
62* Erectile abnormalities (HP:0100639)2.30860843
63Hypoplastic pelvis (HP:0008839)2.30807815
64Medulloblastoma (HP:0002885)2.30131158
65Atrophic scars (HP:0001075)2.29313343
66Biliary tract neoplasm (HP:0100574)2.29041835
67Abnormality of the nasal septum (HP:0000419)2.28339857
68Transitional cell carcinoma of the bladder (HP:0006740)2.26334599
69Esophageal atresia (HP:0002032)2.25256907
70Interstitial pulmonary disease (HP:0006530)2.23606862
71Abnormal biliary tract physiology (HP:0012439)2.20168954
72Bile duct proliferation (HP:0001408)2.20168954
73Abnormal platelet volume (HP:0011876)2.19161359
74Recurrent abscess formation (HP:0002722)2.18528813
75Neoplasm of the tracheobronchial system (HP:0100552)2.18366796
76Keratoconjunctivitis (HP:0001096)2.17812533
77Cutaneous melanoma (HP:0012056)2.17676919
78Broad foot (HP:0001769)2.17292139
79Stomach cancer (HP:0012126)2.17263679
80Median cleft lip (HP:0000161)2.16726125
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.15587594
82Increased mean platelet volume (HP:0011877)2.15129725
83Leukocytosis (HP:0001974)2.14220803
84Abnormality of the preputium (HP:0100587)2.12693572
85Bifid tongue (HP:0010297)2.12273476
86Shallow orbits (HP:0000586)2.11736751
87Duodenal stenosis (HP:0100867)2.11330062
88Small intestinal stenosis (HP:0012848)2.11330062
89Syringomyelia (HP:0003396)2.11279034
90Spinal cord lesions (HP:0100561)2.11279034
91Nephroblastoma (Wilms tumor) (HP:0002667)2.08633086
92Osteomyelitis (HP:0002754)2.08546265
93Increased density of long bones (HP:0006392)2.08253222
94Uterine leiomyosarcoma (HP:0002891)2.06508645
95Leiomyosarcoma (HP:0100243)2.06508645
96Distal lower limb amyotrophy (HP:0008944)2.06455035
97Ascites (HP:0001541)2.05525969
98Embryonal renal neoplasm (HP:0011794)2.05446834
99Prolonged bleeding time (HP:0003010)2.05415277
100Bladder carcinoma (HP:0002862)2.03946181
101Bladder neoplasm (HP:0009725)2.03946181
102Thick nail (HP:0001805)2.02896744
103Abnormal platelet function (HP:0011869)2.02894761
104Impaired platelet aggregation (HP:0003540)2.02894761
105Hyperglycinemia (HP:0002154)2.02684380
106Colitis (HP:0002583)2.01028541
107Skull defect (HP:0001362)2.00491743
108Congenital, generalized hypertrichosis (HP:0004540)2.00012617
109Mitral stenosis (HP:0001718)1.99266354
110Mesangial abnormality (HP:0001966)1.98493523
111Deep venous thrombosis (HP:0002625)1.98480910
112Adactyly (HP:0009776)1.98230410
113Cellulitis (HP:0100658)1.95813841
114Disinhibition (HP:0000734)1.95595252
115Aplasia/hypoplasia of the humerus (HP:0006507)1.95422675
116Aortic dissection (HP:0002647)1.93390226
117Ureteral obstruction (HP:0006000)1.92488370
118Inflammation of the large intestine (HP:0002037)1.92339853
119Capillary hemangiomas (HP:0005306)1.91228386
120Hepatosplenomegaly (HP:0001433)1.91086521
121Anencephaly (HP:0002323)1.90643283
122Arterial thrombosis (HP:0004420)1.89884701
123Gastrointestinal carcinoma (HP:0002672)1.89827703
124Malignant gastrointestinal tract tumors (HP:0006749)1.89827703
125Hepatocellular carcinoma (HP:0001402)1.88419770
126Ureteral stenosis (HP:0000071)1.87556124
127Striae distensae (HP:0001065)1.85913994
128Pancreatic cysts (HP:0001737)1.85849481
129Abnormality of the axillary hair (HP:0100134)1.85820892
130Abnormality of secondary sexual hair (HP:0009888)1.85820892
131Polygenic inheritance (HP:0010982)1.84671506
132Abnormality of the duodenum (HP:0002246)1.84165677
133Viral hepatitis (HP:0006562)1.82614389
134Gastrointestinal inflammation (HP:0004386)1.82095014
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81071980
136Plantar hyperkeratosis (HP:0007556)1.81070485
137Uterine neoplasm (HP:0010784)1.79549695
138Facial diplegia (HP:0001349)1.79144472
139Abnormal hair whorl (HP:0010721)1.78181459
140Enlarged penis (HP:0000040)1.77326728
141Sloping forehead (HP:0000340)1.76194647
142Abnormal foot bone ossification (HP:0010675)1.76184779
143Joint hemorrhage (HP:0005261)1.74651309
144Short humerus (HP:0005792)1.73952827
145Gastrointestinal atresia (HP:0002589)1.73736877
146Long clavicles (HP:0000890)1.73031806
147Ependymoma (HP:0002888)1.72295607
148Anophthalmia (HP:0000528)1.72142902
149Thyroiditis (HP:0100646)1.72030555
150Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71664822
151Microglossia (HP:0000171)1.71102210
152Recurrent bacterial skin infections (HP:0005406)1.69933726
153Growth hormone excess (HP:0000845)1.69640548
154Recurrent gram-negative bacterial infections (HP:0005420)1.68763563
155Palpebral edema (HP:0100540)1.68645397
156Adrenal hypoplasia (HP:0000835)1.68511059
157Clubbing of toes (HP:0100760)1.68353248
158Lymphangioma (HP:0100764)1.68178683
159Myositis (HP:0100614)1.68175067
160Germ cell neoplasia (HP:0100728)1.68167192
161Loss of speech (HP:0002371)1.67219488
162Hypochromic microcytic anemia (HP:0004840)1.66707889
163Acute myeloid leukemia (HP:0004808)1.65962692
164Abnormality of methionine metabolism (HP:0010901)1.65485211
165Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65188640
166Oligodontia (HP:0000677)1.65168410
167Pancreatic fibrosis (HP:0100732)1.64341789
168Submucous cleft hard palate (HP:0000176)1.63322370
169Postaxial foot polydactyly (HP:0001830)1.63092201
170Gonadotropin excess (HP:0000837)1.62745360
171Amyotrophic lateral sclerosis (HP:0007354)1.62625417
172Chronic diarrhea (HP:0002028)1.62609735
173Disproportionate tall stature (HP:0001519)1.61809238
174Abnormality of serum amino acid levels (HP:0003112)1.61667375
175Encephalitis (HP:0002383)1.61508649
176Abnormality of the anterior chamber (HP:0000593)1.60427455
177Urticaria (HP:0001025)1.59746806
178Eosinophilia (HP:0001880)1.59591198
179Ovarian neoplasm (HP:0100615)1.59325008
180Tetraparesis (HP:0002273)1.58128883
181Premature loss of primary teeth (HP:0006323)1.57183611
182Neoplasm of striated muscle (HP:0009728)1.56241687
183Periodontitis (HP:0000704)1.56204206
184Medial flaring of the eyebrow (HP:0010747)1.55722762
185Disproportionate short-trunk short stature (HP:0003521)1.54375402
186Neoplasm of the colon (HP:0100273)1.54104468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.59757199
2CASK4.15277545
3EIF2AK33.66588595
4KDR3.44605172
5TRIM283.17908162
6EPHA23.13854817
7FRK3.06378502
8TIE13.00659393
9ERBB42.91114811
10TNIK2.80129728
11WNK32.53243927
12NLK2.50691745
13PAK42.44040124
14SRPK12.38225797
15BMPR1B2.23960799
16TSSK62.23376889
17BRSK21.98942154
18MAP2K31.91779480
19WEE11.89829767
20STK101.89168906
21TGFBR11.85398828
22BUB11.82943864
23STK38L1.77042984
24KIT1.75499232
25CDK191.65297700
26FLT31.64111011
27ACVR1B1.63237794
28FGR1.63210667
29ERBB31.60696441
30MAP3K121.53685560
31CDC71.53612811
32GRK61.52255222
33TEC1.49948628
34AKT31.48263368
35MAP4K21.46462476
36BCR1.45568342
37MKNK21.43647821
38CDK61.42188465
39MST41.39701198
40MAPK151.38641009
41NEK11.38569049
42MKNK11.37994376
43CSF1R1.34400005
44EIF2AK21.33080883
45PLK41.32297234
46MAP3K141.24939321
47GRK71.23662169
48DYRK31.23320002
49PKN21.23171425
50TRPM71.22215837
51MAP3K31.21148309
52SGK21.19463994
53VRK21.16230243
54CLK11.15698699
55MAPK71.14950201
56FER1.11585589
57SIK31.11269980
58CHUK1.08745563
59RPS6KB21.07297204
60PIM21.05465326
61DAPK21.03992942
62BLK1.03951719
63BRD41.03749764
64CSK1.02365419
65FGFR31.01696581
66PTK2B1.01360589
67PTK61.01015942
68TTK1.00916071
69EPHB20.97886532
70CCNB10.96835682
71PIM10.95700079
72VRK10.91799305
73TESK20.89719864
74TAF10.88288224
75IKBKE0.87639227
76MAPK120.85334491
77MATK0.85192241
78PLK20.84473001
79PDK20.82606376
80CSNK1A1L0.82370383
81ZAP700.81647836
82PLK10.80916114
83NUAK10.80558598
84RIPK10.78447865
85ITK0.77955783
86PBK0.76128925
87CDK80.75957885
88CSNK1G30.75308284
89NME20.74667717
90MAP4K10.74236323
91FGFR10.73309615
92DAPK10.72377738
93BTK0.71812706
94PLK30.70257608
95FGFR20.69943421
96SGK30.69795015
97FGFR40.67949253
98BRSK10.67861137
99FES0.66172333
100EEF2K0.66135023
101CSNK1G20.64050952
102MYLK0.63254908
103IRAK40.61332607
104SCYL20.58768122
105RPS6KC10.57482278
106RPS6KL10.57482278
107NEK90.57028937
108TYK20.56914719
109DYRK1B0.56674779
110YES10.56559525
111GSK3A0.55331866
112RPS6KA40.54514435
113LRRK20.54285436
114CSNK1G10.53258970
115BMX0.53010083
116MAPK40.52277298
117PTK20.51880534
118OXSR10.51499063
119RPS6KA60.49027610
120MAP2K20.47831143
121IGF1R0.46743864
122MAP3K100.46129862
123TAOK20.46080512
124LIMK10.44932732
125LYN0.44796863
126CAMK40.44771106
127EPHA40.44220770
128TBK10.43938483
129MAP2K70.43561722
130MOS0.42270912
131MAP3K50.41469927
132MAPKAPK20.40590400
133IKBKB0.40042736
134ERN10.39599420
135ADRBK20.39463893
136LCK0.38971689
137TESK10.38184961
138PAK20.37632696
139BCKDK0.36198891
140MET0.36169311
141IRAK30.35945575
142ATR0.35631933
143ZAK0.35618357
144EPHB10.34704113
145EGFR0.34581631
146MAP3K110.34466909
147DYRK1A0.34149267
148PRKG20.33283314
149STK240.31045586
150ABL10.29288245
151CAMK1D0.28463611
152MELK0.27670974
153BMPR20.27243405

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.94149717
2Proteasome_Homo sapiens_hsa030502.91175602
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.90839009
4Adherens junction_Homo sapiens_hsa045202.68180242
5Steroid biosynthesis_Homo sapiens_hsa001002.57409084
6Protein export_Homo sapiens_hsa030602.46687231
7Staphylococcus aureus infection_Homo sapiens_hsa051502.45332826
8Non-homologous end-joining_Homo sapiens_hsa034502.43687032
9Mismatch repair_Homo sapiens_hsa034302.18563184
10Leukocyte transendothelial migration_Homo sapiens_hsa046702.18362258
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.12338970
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07545941
13Homologous recombination_Homo sapiens_hsa034402.01739101
14Leishmaniasis_Homo sapiens_hsa051402.01280083
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.00755662
16Fatty acid elongation_Homo sapiens_hsa000621.94262790
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86693352
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85696535
19Complement and coagulation cascades_Homo sapiens_hsa046101.85327723
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78225156
21Pertussis_Homo sapiens_hsa051331.76855205
22Fanconi anemia pathway_Homo sapiens_hsa034601.76006979
23Base excision repair_Homo sapiens_hsa034101.72968419
24Osteoclast differentiation_Homo sapiens_hsa043801.70372645
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69449761
26* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.66837609
27DNA replication_Homo sapiens_hsa030301.65470327
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59165438
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56886882
30Propanoate metabolism_Homo sapiens_hsa006401.54507609
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52815211
32Small cell lung cancer_Homo sapiens_hsa052221.52031017
33Spliceosome_Homo sapiens_hsa030401.44562521
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44375083
35Salmonella infection_Homo sapiens_hsa051321.44096167
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43987526
37Toxoplasmosis_Homo sapiens_hsa051451.43913584
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42625273
39Proteoglycans in cancer_Homo sapiens_hsa052051.42169827
40Focal adhesion_Homo sapiens_hsa045101.40724760
41HIF-1 signaling pathway_Homo sapiens_hsa040661.39379023
42RNA polymerase_Homo sapiens_hsa030201.38710608
43Legionellosis_Homo sapiens_hsa051341.37998243
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36480084
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.30331346
46Chronic myeloid leukemia_Homo sapiens_hsa052201.30152833
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29416900
48Notch signaling pathway_Homo sapiens_hsa043301.28707171
49Colorectal cancer_Homo sapiens_hsa052101.28415675
50MicroRNAs in cancer_Homo sapiens_hsa052061.27946922
51Hepatitis B_Homo sapiens_hsa051611.27856086
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26580869
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26539451
54Malaria_Homo sapiens_hsa051441.24812336
55Thyroid cancer_Homo sapiens_hsa052161.24780297
56African trypanosomiasis_Homo sapiens_hsa051431.23844854
57Prostate cancer_Homo sapiens_hsa052151.21415362
58Shigellosis_Homo sapiens_hsa051311.20549241
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18281106
60Measles_Homo sapiens_hsa051621.16236349
61RNA degradation_Homo sapiens_hsa030181.15999776
62Other glycan degradation_Homo sapiens_hsa005111.15405606
63Hematopoietic cell lineage_Homo sapiens_hsa046401.15339955
64TGF-beta signaling pathway_Homo sapiens_hsa043501.14901546
65Cell cycle_Homo sapiens_hsa041101.13703470
66RNA transport_Homo sapiens_hsa030131.13443144
67Rap1 signaling pathway_Homo sapiens_hsa040151.12512391
68Bladder cancer_Homo sapiens_hsa052191.11817694
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10604980
70Pancreatic cancer_Homo sapiens_hsa052121.09925970
71Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09790132
72B cell receptor signaling pathway_Homo sapiens_hsa046621.09241153
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06494322
74Intestinal immune network for IgA production_Homo sapiens_hsa046721.04400583
75ECM-receptor interaction_Homo sapiens_hsa045121.04065046
76Chemical carcinogenesis_Homo sapiens_hsa052041.03938331
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03619876
78Platelet activation_Homo sapiens_hsa046111.03207938
79HTLV-I infection_Homo sapiens_hsa051661.03060072
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00474558
81Pathways in cancer_Homo sapiens_hsa052000.98824333
82TNF signaling pathway_Homo sapiens_hsa046680.98608995
83Glutathione metabolism_Homo sapiens_hsa004800.98193342
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97855203
85Rheumatoid arthritis_Homo sapiens_hsa053230.96250109
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96052968
87Tuberculosis_Homo sapiens_hsa051520.94877184
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.92494186
89Viral myocarditis_Homo sapiens_hsa054160.92326239
90Influenza A_Homo sapiens_hsa051640.92253921
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90971870
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90636669
93p53 signaling pathway_Homo sapiens_hsa041150.87462785
94Hippo signaling pathway_Homo sapiens_hsa043900.86531437
95Prion diseases_Homo sapiens_hsa050200.86333333
96FoxO signaling pathway_Homo sapiens_hsa040680.86074910
97Viral carcinogenesis_Homo sapiens_hsa052030.84108145
98Biosynthesis of amino acids_Homo sapiens_hsa012300.84082701
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82641457
100Endometrial cancer_Homo sapiens_hsa052130.81421289
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81350644
102Antigen processing and presentation_Homo sapiens_hsa046120.80720248
103Amoebiasis_Homo sapiens_hsa051460.79949883
104Basal transcription factors_Homo sapiens_hsa030220.79804202
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78118182
106Apoptosis_Homo sapiens_hsa042100.78056907
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.77326341
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77312071
109Phagosome_Homo sapiens_hsa041450.76531141
110Melanoma_Homo sapiens_hsa052180.73650331
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72784547
112Starch and sucrose metabolism_Homo sapiens_hsa005000.72194433
113Basal cell carcinoma_Homo sapiens_hsa052170.71654337
114Glioma_Homo sapiens_hsa052140.71541108
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71275497
116Fatty acid degradation_Homo sapiens_hsa000710.70631661
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.70048543
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.70038712
119Pyrimidine metabolism_Homo sapiens_hsa002400.69191468
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.68798410
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68739348
122Acute myeloid leukemia_Homo sapiens_hsa052210.68065583
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67333261
124Herpes simplex infection_Homo sapiens_hsa051680.67084517
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66909166
126Fatty acid metabolism_Homo sapiens_hsa012120.66135698
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64187687
128Lysosome_Homo sapiens_hsa041420.63120803
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.62759244
130Hepatitis C_Homo sapiens_hsa051600.61298130
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61203786
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60344306
133Carbon metabolism_Homo sapiens_hsa012000.59990615
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58553370
135Pyruvate metabolism_Homo sapiens_hsa006200.58329628
136Tight junction_Homo sapiens_hsa045300.57443863
137Systemic lupus erythematosus_Homo sapiens_hsa053220.57412968
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.56972964
139Non-small cell lung cancer_Homo sapiens_hsa052230.56563599
140Retinol metabolism_Homo sapiens_hsa008300.55295297
141Nucleotide excision repair_Homo sapiens_hsa034200.54410526
142Wnt signaling pathway_Homo sapiens_hsa043100.53524684
143Epstein-Barr virus infection_Homo sapiens_hsa051690.53255190
144Vitamin digestion and absorption_Homo sapiens_hsa049770.52065446
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49556312
146Melanogenesis_Homo sapiens_hsa049160.49323654
147Axon guidance_Homo sapiens_hsa043600.49211641
148Graft-versus-host disease_Homo sapiens_hsa053320.48694712
149Purine metabolism_Homo sapiens_hsa002300.48627600
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45324220
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42818890
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38922977
153Glycerolipid metabolism_Homo sapiens_hsa005610.34176212

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