DUSP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)6.27079871
2keratinocyte proliferation (GO:0043616)5.68542861
3cell-substrate junction assembly (GO:0007044)5.63254883
4hypotonic response (GO:0006971)4.45212340
5axon ensheathment in central nervous system (GO:0032291)4.28803481
6central nervous system myelination (GO:0022010)4.28803481
7desmosome organization (GO:0002934)4.02207967
8bundle of His cell to Purkinje myocyte communication (GO:0086069)3.98016345
9hemidesmosome assembly (GO:0031581)3.95571775
10skin morphogenesis (GO:0043589)3.88085367
11regulation of cardioblast differentiation (GO:0051890)3.77198150
12peptide cross-linking (GO:0018149)3.65125528
13axon ensheathment (GO:0008366)3.63871076
14ensheathment of neurons (GO:0007272)3.63871076
15myelination (GO:0042552)3.56357748
16long-chain fatty acid biosynthetic process (GO:0042759)3.50482404
17cell-substrate adherens junction assembly (GO:0007045)3.39455418
18focal adhesion assembly (GO:0048041)3.39455418
19epidermis development (GO:0008544)3.38523201
20adherens junction assembly (GO:0034333)3.34821651
21detection of bacterium (GO:0016045)3.34641868
22detection of other organism (GO:0098543)3.29888989
23protein localization to endosome (GO:0036010)3.29782182
24myelination in peripheral nervous system (GO:0022011)3.25649730
25peripheral nervous system axon ensheathment (GO:0032292)3.25649730
26negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.17718134
27epidermal cell differentiation (GO:0009913)3.17671523
28stress fiber assembly (GO:0043149)3.17208142
29regulation of transforming growth factor beta2 production (GO:0032909)3.12617601
30regulation of meiosis (GO:0040020)3.11695998
31multicellular organismal water homeostasis (GO:0050891)3.11208442
32membrane raft organization (GO:0031579)3.10044002
33activation of Rac GTPase activity (GO:0032863)3.08729734
34glycerophospholipid catabolic process (GO:0046475)3.06482332
35cytoplasmic mRNA processing body assembly (GO:0033962)3.04274874
36regulation of exit from mitosis (GO:0007096)3.02180028
37signal complex assembly (GO:0007172)3.01471686
38atrioventricular valve morphogenesis (GO:0003181)2.97197738
39eye photoreceptor cell differentiation (GO:0001754)2.97033340
40photoreceptor cell differentiation (GO:0046530)2.97033340
41apical protein localization (GO:0045176)2.95967901
42cell migration involved in heart development (GO:0060973)2.94536299
43female gamete generation (GO:0007292)2.93198655
44intermediate filament organization (GO:0045109)2.88686625
45angiogenesis involved in wound healing (GO:0060055)2.88583683
46negative regulation of keratinocyte proliferation (GO:0010839)2.88025039
47positive regulation of epidermis development (GO:0045684)2.87225310
48negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87055946
49negative regulation of hormone metabolic process (GO:0032351)2.82273651
50negative regulation of hormone biosynthetic process (GO:0032353)2.82273651
51asymmetric protein localization (GO:0008105)2.82140696
52regulation of establishment of cell polarity (GO:2000114)2.82137797
53ephrin receptor signaling pathway (GO:0048013)2.81082719
54negative regulation of erythrocyte differentiation (GO:0045647)2.79114699
55endodermal cell differentiation (GO:0035987)2.76246658
56epithelial cell differentiation involved in prostate gland development (GO:0060742)2.72936432
57sphingosine metabolic process (GO:0006670)2.71885660
58regulation of clathrin-mediated endocytosis (GO:2000369)2.71377606
59negative regulation of skeletal muscle tissue development (GO:0048642)2.71094406
60cellular protein complex localization (GO:0034629)2.69506373
61regulation of meiotic cell cycle (GO:0051445)2.69483811
62keratinization (GO:0031424)2.66746987
63macrophage activation involved in immune response (GO:0002281)2.66272743
64surfactant homeostasis (GO:0043129)2.65935596
65positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.64606662
66sodium ion export (GO:0071436)2.64068859
67fatty acid elongation (GO:0030497)2.63442555
68positive regulation of meiotic cell cycle (GO:0051446)2.61534531
69negative regulation of protein localization to cell surface (GO:2000009)2.61089853
70lateral sprouting from an epithelium (GO:0060601)2.59692715
71pinocytosis (GO:0006907)2.59141852
72positive regulation of receptor recycling (GO:0001921)2.59004249
73regulation of female gonad development (GO:2000194)2.58743984
74positive regulation of hair cycle (GO:0042635)2.58459686
75positive regulation of hair follicle development (GO:0051798)2.58459686
76positive regulation of protein export from nucleus (GO:0046827)2.57445314
77peptidyl-tyrosine autophosphorylation (GO:0038083)2.57136120
78hair cycle (GO:0042633)2.56850890
79molting cycle (GO:0042303)2.56850890
80positive regulation of microtubule polymerization (GO:0031116)2.55237268
81regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.54806742
82membrane tubulation (GO:0097320)2.53552545
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53239148
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53239148
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.53239148
86modulation by symbiont of host immune response (GO:0052553)2.53239148
87positive regulation by symbiont of host defense response (GO:0052509)2.53239148
88modulation by symbiont of host defense response (GO:0052031)2.53239148
89substrate-dependent cell migration (GO:0006929)2.51164020
90keratinocyte differentiation (GO:0030216)2.50893398
91response to laminar fluid shear stress (GO:0034616)2.50590716
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49091997
93negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.48737360
94myelin maintenance (GO:0043217)2.47402105
95organ growth (GO:0035265)2.47301196
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46667610
97notochord development (GO:0030903)2.46491080
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.46224151
99cell junction organization (GO:0034330)2.45587646
100positive regulation of epidermal cell differentiation (GO:0045606)2.45467587
101keratinocyte development (GO:0003334)2.45254818
102regulation of keratinocyte proliferation (GO:0010837)2.45026156
103positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44682782
104protein localization to microtubule (GO:0035372)2.44534328
105water homeostasis (GO:0030104)2.43927911
106positive regulation of meiosis (GO:0045836)2.43427009
107protein kinase C signaling (GO:0070528)2.42087955
108positive regulation of fibroblast migration (GO:0010763)2.42043908
109regulation of transforming growth factor beta1 production (GO:0032908)2.41916203
110regulation of hair follicle development (GO:0051797)2.41380299
111platelet-derived growth factor receptor signaling pathway (GO:0048008)2.41321847
112piRNA metabolic process (GO:0034587)2.41208156
113cell junction assembly (GO:0034329)2.40848265
114regulation of histone H3-K27 methylation (GO:0061085)2.40791452
115cardiac myofibril assembly (GO:0055003)2.40284021
116face morphogenesis (GO:0060325)2.39503655
117eyelid development in camera-type eye (GO:0061029)2.37631461
118negative regulation of neurotransmitter secretion (GO:0046929)2.35484506
119regulation of tight junction assembly (GO:2000810)2.33837838
120microtubule severing (GO:0051013)2.33687354
121DNA damage induced protein phosphorylation (GO:0006975)2.33181656
122leukocyte aggregation (GO:0070486)2.32623419
123diol metabolic process (GO:0034311)2.31277991
124negative regulation of axon extension involved in axon guidance (GO:0048843)2.30283448
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30154539
126oligodendrocyte differentiation (GO:0048709)2.29957696
127plasma membrane repair (GO:0001778)2.29507557
128cartilage morphogenesis (GO:0060536)2.29381782
129sprouting angiogenesis (GO:0002040)2.29349103
130megakaryocyte development (GO:0035855)2.29116664
131positive regulation of Wnt signaling pathway (GO:0030177)2.28791618
132L-amino acid import (GO:0043092)2.28071892
133type B pancreatic cell development (GO:0003323)2.24974933
134sphingoid metabolic process (GO:0046519)2.24321352
135cerebral cortex radially oriented cell migration (GO:0021799)2.23439246
136positive regulation of neurological system process (GO:0031646)2.21141365
137negative regulation of chondrocyte differentiation (GO:0032331)2.21088901
138regulation of establishment or maintenance of cell polarity (GO:0032878)2.20998192
139SMAD protein complex assembly (GO:0007183)2.20935740
140mitotic chromosome condensation (GO:0007076)2.20518546
141mesodermal cell differentiation (GO:0048333)2.19943310
142embryonic process involved in female pregnancy (GO:0060136)2.19886292
143cell adhesion mediated by integrin (GO:0033627)2.19199505
144actin filament bundle organization (GO:0061572)2.19111222
145actin filament bundle assembly (GO:0051017)2.19111222
146negative regulation of T cell mediated immunity (GO:0002710)2.18850283
147positive regulation of protein dephosphorylation (GO:0035307)2.18779396
148cellular response to gamma radiation (GO:0071480)2.18331363
149gap junction assembly (GO:0016264)2.17214664
150somatic stem cell division (GO:0048103)2.17122442
151mammary gland epithelial cell proliferation (GO:0033598)2.16848362
152DNA damage response, signal transduction resulting in transcription (GO:0042772)2.16698416
153cellular response to fluid shear stress (GO:0071498)2.16595683
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.16072743
155negative regulation of execution phase of apoptosis (GO:1900118)2.16059891
156microtubule polymerization or depolymerization (GO:0031109)2.16021889
157positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.15040685
158pathway-restricted SMAD protein phosphorylation (GO:0060389)2.14482651
159centrosome localization (GO:0051642)2.14389765
160cortical cytoskeleton organization (GO:0030865)2.14093132
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13948611
162Rac protein signal transduction (GO:0016601)2.13757846
163regulation of Rap GTPase activity (GO:0032317)2.13732060
164dendritic spine morphogenesis (GO:0060997)2.13582105
165apoptotic process involved in morphogenesis (GO:0060561)2.13534530
166adherens junction organization (GO:0034332)2.12944572
167adenosine receptor signaling pathway (GO:0001973)2.12319148
168regulation of translational termination (GO:0006449)2.12164477
169myofibril assembly (GO:0030239)2.11987489
170detection of external biotic stimulus (GO:0098581)2.11627880
171endocytic recycling (GO:0032456)2.10694111
172regulation of natural killer cell differentiation (GO:0032823)2.10592811
173negative regulation of muscle organ development (GO:0048635)2.10199355
174regulation of early endosome to late endosome transport (GO:2000641)2.09254957
175regulation of retinoic acid receptor signaling pathway (GO:0048385)2.09018216
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.08995463
177gland morphogenesis (GO:0022612)2.08679416
178negative regulation of neurotransmitter transport (GO:0051589)2.08610032
179embryonic body morphogenesis (GO:0010172)2.07814079
180regulation of smooth muscle cell differentiation (GO:0051150)2.07637195
181regulation of water loss via skin (GO:0033561)2.06387525
182regulation of hair cycle (GO:0042634)2.05437393
183regulation of cardiac muscle cell differentiation (GO:2000725)2.05023997
184regulation of somitogenesis (GO:0014807)2.04980254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09994109
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.97754172
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82654698
4* ELK3_25401928_ChIP-Seq_HUVEC_Human2.68414982
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59588732
6AR_21572438_ChIP-Seq_LNCaP_Human2.53032923
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52782666
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.42979884
9P63_26484246_Chip-Seq_KERATINOCYTES_Human2.32302342
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30372368
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.24052633
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.24052633
13EZH2_22144423_ChIP-Seq_EOC_Human2.12617263
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07641413
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02880879
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02880879
17* VDR_21846776_ChIP-Seq_THP-1_Human2.02210460
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02024713
19* TCF7_22412390_ChIP-Seq_EML_Mouse1.97180189
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95559566
21MYC_22102868_ChIP-Seq_BL_Human1.93652700
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92595900
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.89716415
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.89615273
25P300_27058665_Chip-Seq_ZR-75-30cells_Human1.88914939
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87211383
27* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.84851342
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83860772
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83008406
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.81913853
31* KDM2B_26808549_Chip-Seq_DND41_Human1.81577053
32* LXR_22292898_ChIP-Seq_THP-1_Human1.78863516
33VDR_24763502_ChIP-Seq_THP-1_Human1.75883268
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.74656034
35GBX2_23144817_ChIP-Seq_PC3_Human1.74259255
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.73337609
37* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72921415
38RACK7_27058665_Chip-Seq_MCF-7_Human1.72819842
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69379608
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.69253082
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.66161754
42TP53_16413492_ChIP-PET_HCT116_Human1.65434891
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64931381
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60406084
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59040339
46ATF3_27146783_Chip-Seq_COLON_Human1.58273973
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.57487828
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55147187
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54153194
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53244063
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51971864
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48135791
53* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47449629
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.45890766
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45159051
56AHR_22903824_ChIP-Seq_MCF-7_Human1.44617312
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44129807
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43253024
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42517928
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42156156
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38667311
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37976281
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37523064
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.34960524
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.33948823
66* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33239641
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33108092
68* MAF_26560356_Chip-Seq_TH1_Human1.32677864
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32370791
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31838540
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.31574923
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31428560
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29195819
74* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28749537
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28677549
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28479942
77CJUN_26792858_Chip-Seq_BT549_Human1.28324223
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27915991
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.27581447
80* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26649400
81* EED_16625203_ChIP-ChIP_MESCs_Mouse1.26475551
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25300454
83* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24520404
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23756134
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23524401
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23343950
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23015378
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.22940695
89KDM2B_26808549_Chip-Seq_K562_Human1.22786161
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22682010
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22558496
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.21119048
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20953838
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20414340
95TP63_22573176_ChIP-Seq_HFKS_Human1.20266991
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19824950
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18178563
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18060561
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17608878
100RXR_22108803_ChIP-Seq_LS180_Human1.17014550
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.15560008
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.15560008
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15556956
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.15325451
105FUS_26573619_Chip-Seq_HEK293_Human1.14893260
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.13283436
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13272664
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.12823195
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12560564
110CLOCK_20551151_ChIP-Seq_293T_Human1.12123074
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.12021791
112VDR_22108803_ChIP-Seq_LS180_Human1.11736422
113* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11568916
114* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10852376
115DROSHA_22980978_ChIP-Seq_HELA_Human1.10657862
116* TP63_23658742_ChIP-Seq_EP156T_Human1.10440810
117RNF2_27304074_Chip-Seq_NSC_Mouse1.10262070
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09812538
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09667208
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09507972
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.09195753
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08667238
123STAT3_23295773_ChIP-Seq_U87_Human1.07642852
124RARB_27405468_Chip-Seq_BRAIN_Mouse1.07638974
125* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07595856
126* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06608602
127FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06294196
128KDM2B_26808549_Chip-Seq_JURKAT_Human1.04885168
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.04492875
130* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04332503
131TBL1_22424771_ChIP-Seq_293T_Human1.04092496
132TP53_22127205_ChIP-Seq_IMR90_Human1.03669207
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03170222
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03161294
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02658297
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02127789
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01980289
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01958404
139CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01918566
140KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01665221
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00278417
142SPI1_23127762_ChIP-Seq_K562_Human0.99877127
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99780150
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99187959
145BRD4_25478319_ChIP-Seq_HGPS_Human0.98594940
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.98039377
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96876618
148OCT1_27270436_Chip-Seq_PROSTATE_Human0.96582264
149SMAD4_21799915_ChIP-Seq_A2780_Human0.95600101
150SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95116001
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94687502
152FOXM1_23109430_ChIP-Seq_U2OS_Human0.93924525
153* UTX_26944678_Chip-Seq_JUKART_Human0.93584510
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93539428
155* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93262442
156* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93241109
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93038515
158KLF5_25053715_ChIP-Seq_YYC3_Human0.91715940
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91487175
160VDR_24787735_ChIP-Seq_THP-1_Human0.91336361
161MAF_26560356_Chip-Seq_TH2_Human0.91309448
162TP53_18474530_ChIP-ChIP_U2OS_Human0.91251038
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90751344
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90271727
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90271727
166SOX2_21211035_ChIP-Seq_LN229_Gbm0.88608977
167* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88380666
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88339868
169RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86383606
170FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85647819
171STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85221745
172JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85100183
173TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83946958
174TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83872913
175* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83675152
176DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81684601
177TP53_23651856_ChIP-Seq_MEFs_Mouse0.80588374
178NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79769563
179SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78812009
180Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77950147
181RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77108096
182FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77105121
183* CREB1_26743006_Chip-Seq_LNCaP_Human0.76620246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.73072411
2MP0000579_abnormal_nail_morphology3.26429111
3MP0000383_abnormal_hair_follicle2.77991975
4MP0004185_abnormal_adipocyte_glucose2.76920978
5MP0010678_abnormal_skin_adnexa2.75948217
6MP0008260_abnormal_autophagy2.72514871
7MP0002796_impaired_skin_barrier2.60585748
8MP0000566_synostosis2.33089242
9MP0003950_abnormal_plasma_membrane2.27771537
10MP0003191_abnormal_cellular_cholesterol2.19343658
11MP0010234_abnormal_vibrissa_follicle2.17365133
12MP0005275_abnormal_skin_tensile2.16132292
13MP0004859_abnormal_synaptic_plasticity2.15032525
14MP0003646_muscle_fatigue1.98779265
15MP0000920_abnormal_myelination1.96544529
16MP0001851_eye_inflammation1.95728744
17MP0004381_abnormal_hair_follicle1.88195784
18MP0004270_analgesia1.79411066
19MP0003880_abnormal_central_pattern1.78724005
20MP0000762_abnormal_tongue_morphology1.77346771
21MP0002102_abnormal_ear_morphology1.76870521
22MP0001849_ear_inflammation1.74612018
23MP0003453_abnormal_keratinocyte_physiol1.72535315
24MP0003718_maternal_effect1.71090862
25MP0003937_abnormal_limbs/digits/tail_de1.67576370
26MP0004145_abnormal_muscle_electrophysio1.62915722
27MP0004947_skin_inflammation1.61166359
28MP0003385_abnormal_body_wall1.56433421
29MP0003828_pulmonary_edema1.52717452
30MP0006054_spinal_hemorrhage1.52216187
31MP0009931_abnormal_skin_appearance1.51975209
32MP0002060_abnormal_skin_morphology1.51304282
33MP0009384_cardiac_valve_regurgitation1.50393640
34MP0005501_abnormal_skin_physiology1.50087439
35MP0001529_abnormal_vocalization1.49521922
36MP0000467_abnormal_esophagus_morphology1.49370971
37MP0002396_abnormal_hematopoietic_system1.46713486
38MP0001346_abnormal_lacrimal_gland1.46106854
39MP0005409_darkened_coat_color1.46003024
40MP0002098_abnormal_vibrissa_morphology1.43137513
41MP0001216_abnormal_epidermal_layer1.42578360
42MP0000647_abnormal_sebaceous_gland1.42459959
43MP0010771_integument_phenotype1.40961058
44MP0002877_abnormal_melanocyte_morpholog1.40149814
45MP0002249_abnormal_larynx_morphology1.38030387
46MP0003755_abnormal_palate_morphology1.37165993
47MP0009250_abnormal_appendicular_skeleto1.34495592
48MP0010352_gastrointestinal_tract_polyps1.33037685
49MP0003941_abnormal_skin_development1.31457680
50MP0002653_abnormal_ependyma_morphology1.31194389
51MP0004484_altered_response_of1.28447989
52MP0003787_abnormal_imprinting1.27644481
53MP0008438_abnormal_cutaneous_collagen1.25323729
54MP0006138_congestive_heart_failure1.25193134
55MP0000751_myopathy1.22741431
56MP0000462_abnormal_digestive_system1.22472645
57MP0000377_abnormal_hair_follicle1.21878697
58MP0004084_abnormal_cardiac_muscle1.20150511
59MP0004272_abnormal_basement_membrane1.17935492
60MP0001299_abnormal_eye_distance/1.16294005
61MP0000733_abnormal_muscle_development1.15573453
62MP0000003_abnormal_adipose_tissue1.15443447
63MP0003279_aneurysm1.15384732
64MP0004036_abnormal_muscle_relaxation1.14322719
65MP0000427_abnormal_hair_cycle1.14180523
66MP0010368_abnormal_lymphatic_system1.10056116
67MP0001915_intracranial_hemorrhage1.08925410
68MP0003690_abnormal_glial_cell1.08600894
69MP0000678_abnormal_parathyroid_gland1.04881217
70MP0003436_decreased_susceptibility_to1.04798571
71MP0000858_altered_metastatic_potential1.04396303
72MP0005408_hypopigmentation1.03793322
73MP0001340_abnormal_eyelid_morphology1.01875426
74MP0003705_abnormal_hypodermis_morpholog1.01548170
75MP0003566_abnormal_cell_adhesion1.00398613
76MP0002177_abnormal_outer_ear0.98772409
77MP0000767_abnormal_smooth_muscle0.98415731
78MP0003938_abnormal_ear_development0.97885338
79MP0000778_abnormal_nervous_system0.97754918
80MP0003300_gastrointestinal_ulcer0.97188479
81MP0005171_absent_coat_pigmentation0.95659885
82MP0001191_abnormal_skin_condition0.95174115
83MP0004087_abnormal_muscle_fiber0.94267620
84MP0000015_abnormal_ear_pigmentation0.93259319
85MP0001958_emphysema0.92354955
86MP0005257_abnormal_intraocular_pressure0.90249791
87MP0003763_abnormal_thymus_physiology0.90239442
88MP0004510_myositis0.90210977
89MP0005620_abnormal_muscle_contractility0.89131910
90MP0002972_abnormal_cardiac_muscle0.88667393
91MP0000432_abnormal_head_morphology0.88631313
92MP0003045_fibrosis0.88195365
93MP0001243_abnormal_dermal_layer0.88079572
94MP0000537_abnormal_urethra_morphology0.87556393
95MP0005623_abnormal_meninges_morphology0.87266646
96MP0005508_abnormal_skeleton_morphology0.86930874
97MP0005375_adipose_tissue_phenotype0.85657139
98MP0003935_abnormal_craniofacial_develop0.85022056
99MP0003635_abnormal_synaptic_transmissio0.84510836
100MP0001486_abnormal_startle_reflex0.84440437
101MP0005076_abnormal_cell_differentiation0.84083949
102MP0001905_abnormal_dopamine_level0.83904274
103MP0002233_abnormal_nose_morphology0.83728339
104MP0003091_abnormal_cell_migration0.83482799
105MP0002234_abnormal_pharynx_morphology0.82132532
106MP0000367_abnormal_coat/_hair0.81773533
107MP0003632_abnormal_nervous_system0.81547614
108MP0002837_dystrophic_cardiac_calcinosis0.81162968
109MP0000750_abnormal_muscle_regeneration0.80929473
110MP0000759_abnormal_skeletal_muscle0.80792281
111MP0005464_abnormal_platelet_physiology0.79895581
112MP0005621_abnormal_cell_physiology0.79503012
113MP0002282_abnormal_trachea_morphology0.79104131
114MP0005023_abnormal_wound_healing0.78390362
115MP0003448_altered_tumor_morphology0.78196471
116MP0001784_abnormal_fluid_regulation0.77688270
117MP0003136_yellow_coat_color0.77514190
118MP0002116_abnormal_craniofacial_bone0.77192485
119MP0004264_abnormal_extraembryonic_tissu0.76298278
120MP0002106_abnormal_muscle_physiology0.75940958
121MP0004085_abnormal_heartbeat0.75844040
122MP0000685_abnormal_immune_system0.74181962
123MP0010030_abnormal_orbit_morphology0.74060043
124MP0003699_abnormal_female_reproductive0.73883030
125MP0009333_abnormal_splenocyte_physiolog0.73388779
126MP0009053_abnormal_anal_canal0.73076217
127MP0003329_amyloid_beta_deposits0.72539624
128MP0005395_other_phenotype0.71845991
129MP0000749_muscle_degeneration0.70580031
130MP0002925_abnormal_cardiovascular_devel0.70245627
131MP0001348_abnormal_lacrimal_gland0.69690746
132MP0009780_abnormal_chondrocyte_physiolo0.68273712
133MP0004885_abnormal_endolymph0.67703688
134MP0002085_abnormal_embryonic_tissue0.67151285
135MP0002109_abnormal_limb_morphology0.66671314
136MP0010630_abnormal_cardiac_muscle0.65951057
137MP0003634_abnormal_glial_cell0.65155546
138MP0005369_muscle_phenotype0.65120501
139MP0002998_abnormal_bone_remodeling0.63785948
140MP0000465_gastrointestinal_hemorrhage0.63202467
141MP0009840_abnormal_foam_cell0.62040238
142MP0002896_abnormal_bone_mineralization0.61252418
143MP0003315_abnormal_perineum_morphology0.61166348
144MP0001542_abnormal_bone_strength0.60449411
145MP0001730_embryonic_growth_arrest0.59064268
146MP0002419_abnormal_innate_immunity0.58823587
147MP0002086_abnormal_extraembryonic_tissu0.58390088
148MP0001533_abnormal_skeleton_physiology0.56735007
149MP0003183_abnormal_peptide_metabolism0.56496552
150MP0000013_abnormal_adipose_tissue0.55596926
151MP0004134_abnormal_chest_morphology0.54659717
152MP0001614_abnormal_blood_vessel0.53744408
153MP0005164_abnormal_response_to0.53318130

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)4.82373825
2Palmar hyperkeratosis (HP:0010765)4.53222275
3Milia (HP:0001056)3.82310487
4Ridged nail (HP:0001807)3.70516748
5Lip pit (HP:0100267)3.61684556
6Abnormal blistering of the skin (HP:0008066)3.51295950
7Obstructive sleep apnea (HP:0002870)3.45934942
8Arterial tortuosity (HP:0005116)3.45933878
9Increased IgE level (HP:0003212)3.36764825
10Oral leukoplakia (HP:0002745)3.33207846
11Fragile skin (HP:0001030)3.25764419
12Parakeratosis (HP:0001036)3.22444986
13Thick nail (HP:0001805)3.14198665
14Shallow orbits (HP:0000586)3.09598360
15Vascular tortuosity (HP:0004948)3.06906243
16Fragile nails (HP:0001808)2.99290819
17Distal lower limb muscle weakness (HP:0009053)2.91708174
18Muscle fiber splitting (HP:0003555)2.90390571
19Male infertility (HP:0003251)2.74966594
20Degeneration of the lateral corticospinal tracts (HP:0002314)2.73039800
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73039800
22Aplasia involving bones of the upper limbs (HP:0009823)2.71194999
23Aplasia of the phalanges of the hand (HP:0009802)2.71194999
24Aplasia involving bones of the extremities (HP:0009825)2.71194999
25Natal tooth (HP:0000695)2.69095325
26Sensory axonal neuropathy (HP:0003390)2.68830346
27Ankyloglossia (HP:0010296)2.68534415
28Atrophic scars (HP:0001075)2.66068988
29Hypotrichosis (HP:0001006)2.65778597
30Erythema (HP:0010783)2.65200514
31Chin dimple (HP:0010751)2.63748276
32Sparse scalp hair (HP:0002209)2.62818653
33Sparse eyelashes (HP:0000653)2.62116695
34Abnormality of the axillary hair (HP:0100134)2.61062817
35Abnormality of secondary sexual hair (HP:0009888)2.61062817
36Selective tooth agenesis (HP:0001592)2.59273743
37Sudden death (HP:0001699)2.53901516
38Adrenal hypoplasia (HP:0000835)2.48868298
39Aplasia cutis congenita (HP:0001057)2.45774950
40Plantar hyperkeratosis (HP:0007556)2.39273833
41Absent eyelashes (HP:0000561)2.36686991
42Neurofibrillary tangles (HP:0002185)2.35352271
43Ectropion (HP:0000656)2.34821272
44Follicular hyperkeratosis (HP:0007502)2.33940453
45Facial hemangioma (HP:0000329)2.32741830
46Peripheral hypomyelination (HP:0007182)2.30408559
47Midline defect of the nose (HP:0004122)2.30262282
48Erythroderma (HP:0001019)2.29907187
49Ventricular tachycardia (HP:0004756)2.29723160
50Abnormal hair laboratory examination (HP:0003328)2.29024202
51Palmoplantar keratoderma (HP:0000982)2.26903789
52Esophageal atresia (HP:0002032)2.25133547
53Hyporeflexia of lower limbs (HP:0002600)2.25037375
54Papillary thyroid carcinoma (HP:0002895)2.22526398
55Corneal erosion (HP:0200020)2.21391401
56Pustule (HP:0200039)2.20013426
57Abnormality of oral frenula (HP:0000190)2.18808867
58Sparse lateral eyebrow (HP:0005338)2.18739986
59Advanced eruption of teeth (HP:0006288)2.17643339
60Increased connective tissue (HP:0009025)2.17259908
61Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16719675
62Thickened helices (HP:0000391)2.16046308
63Difficulty running (HP:0009046)2.15471878
64Right ventricular cardiomyopathy (HP:0011663)2.15212977
65Hypoplasia of dental enamel (HP:0006297)2.09237821
66Pili torti (HP:0003777)2.07864211
67Premature rupture of membranes (HP:0001788)2.07579919
68Termporal pattern (HP:0011008)2.07407622
69Insidious onset (HP:0003587)2.07407622
70Broad face (HP:0000283)1.98730900
71Spondylolisthesis (HP:0003302)1.98667251
72Onycholysis (HP:0001806)1.97268712
73Multifactorial inheritance (HP:0001426)1.96944351
74Anonychia (HP:0001798)1.95803431
75Atrial fibrillation (HP:0005110)1.95709511
76Scapular winging (HP:0003691)1.95551065
77Flat capital femoral epiphysis (HP:0003370)1.94476760
78Abnormality of the parietal bone (HP:0002696)1.93879276
79Premature skin wrinkling (HP:0100678)1.93816016
80Onion bulb formation (HP:0003383)1.93023952
81Achilles tendon contracture (HP:0001771)1.92793406
82Curly hair (HP:0002212)1.92792198
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92073491
84Short 4th metacarpal (HP:0010044)1.92073491
85Abnormality of nail color (HP:0100643)1.91059639
86Abnormality of skeletal muscle fiber size (HP:0012084)1.89156337
87Skin pits (HP:0100276)1.88868248
88Aortic dissection (HP:0002647)1.88382331
89Round ear (HP:0100830)1.88192618
90Skin ulcer (HP:0200042)1.87917475
91Deep palmar crease (HP:0006191)1.87516674
92Spinal cord compression (HP:0002176)1.87228042
93Cerebral inclusion bodies (HP:0100314)1.86443551
94Popliteal pterygium (HP:0009756)1.85920522
95Abnormality of the distal phalanges of the toes (HP:0010182)1.85787586
96Abnormality of the salivary glands (HP:0010286)1.85301651
97Increased variability in muscle fiber diameter (HP:0003557)1.85103454
98Dry hair (HP:0011359)1.84975734
99Primary atrial arrhythmia (HP:0001692)1.82896306
100Reduced subcutaneous adipose tissue (HP:0003758)1.82795882
101Septate vagina (HP:0001153)1.82569967
102Axonal loss (HP:0003447)1.82041839
103Abnormality of the neuromuscular junction (HP:0003398)1.80859881
104Fatigable weakness (HP:0003473)1.80859881
105Hip contracture (HP:0003273)1.80623070
106Oligodontia (HP:0000677)1.80429264
107Abnormal auditory evoked potentials (HP:0006958)1.78451818
108Hyperhidrosis (HP:0000975)1.78204997
109Abnormality of the middle phalanges of the toes (HP:0010183)1.77466131
110Trismus (HP:0000211)1.77127909
111Protrusio acetabuli (HP:0003179)1.76318895
112Hypoplastic pelvis (HP:0008839)1.76124849
113Amniotic constriction ring (HP:0009775)1.74987774
114Abnormality of placental membranes (HP:0011409)1.74987774
115Xerostomia (HP:0000217)1.74321806
116Distal lower limb amyotrophy (HP:0008944)1.74068131
117Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73285944
118Carious teeth (HP:0000670)1.73190661
119Blepharitis (HP:0000498)1.72394098
120Pterygium (HP:0001059)1.70850289
121Spinal rigidity (HP:0003306)1.70543306
122Centrally nucleated skeletal muscle fibers (HP:0003687)1.69503510
123Abnormality of carpal bone ossification (HP:0006257)1.69011191
124Congenital ichthyosiform erythroderma (HP:0007431)1.68499560
125Elbow flexion contracture (HP:0002987)1.68328893
126Disproportionate tall stature (HP:0001519)1.67912651
127Atonic seizures (HP:0010819)1.67784112
128Distal upper limb amyotrophy (HP:0007149)1.67045821
129Upper limb amyotrophy (HP:0009129)1.67045821
130Coronal craniosynostosis (HP:0004440)1.66373112
131Cupped ear (HP:0000378)1.66120841
132Nasolacrimal duct obstruction (HP:0000579)1.65413211
133Dysmetria (HP:0001310)1.65121804
134Abnormality of the 4th metacarpal (HP:0010012)1.64818355
135Laryngomalacia (HP:0001601)1.64462002
136Aplasia/Hypoplasia of the breasts (HP:0010311)1.63901780
137Supranuclear gaze palsy (HP:0000605)1.63874558
138Polygenic inheritance (HP:0010982)1.63819533
139Shawl scrotum (HP:0000049)1.63596137
140Supraventricular tachycardia (HP:0004755)1.63590940
141Long palpebral fissure (HP:0000637)1.63255625
142J-shaped sella turcica (HP:0002680)1.62225719
143Wrist flexion contracture (HP:0001239)1.62085737
144Palmoplantar hyperkeratosis (HP:0000972)1.61750437
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.61330379
146Abnormality of the labia minora (HP:0012880)1.61242183
147Hypoplasia of the iris (HP:0007676)1.61028701
148Preaxial foot polydactyly (HP:0001841)1.60849886
149Difficulty climbing stairs (HP:0003551)1.60528177
150Abnormality of the corticospinal tract (HP:0002492)1.60438957
151Breast hypoplasia (HP:0003187)1.60416295
152Supraventricular arrhythmia (HP:0005115)1.60278677
153Syringomyelia (HP:0003396)1.60262831
154Spinal cord lesions (HP:0100561)1.60262831
155Abnormality of the fingernails (HP:0001231)1.60066796
156Limited hip movement (HP:0008800)1.59475579
157Absent hand (HP:0004050)1.59383640
158Eczematoid dermatitis (HP:0000976)1.59031230
159Steppage gait (HP:0003376)1.58575089
160Abnormality of the 2nd finger (HP:0004100)1.58550675
161Corneal dystrophy (HP:0001131)1.58253818
162Woolly hair (HP:0002224)1.58231044
163Abnormality of the fingertips (HP:0001211)1.58205675
164Genetic anticipation (HP:0003743)1.57761818
165Abnormal ossification of hand bones (HP:0005921)1.57712490
166Microglossia (HP:0000171)1.55807627
167Breast aplasia (HP:0100783)1.55508574
168Abnormality of the calf musculature (HP:0001430)1.55488115
169Hypoplastic ischia (HP:0003175)1.54665106
170Broad metatarsal (HP:0001783)1.54527338
171Nail dystrophy (HP:0008404)1.53691517
172Abnormality of chromosome segregation (HP:0002916)1.53624654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.71039709
2LATS24.41042063
3MAP3K63.06677134
4STK38L2.72021464
5DMPK2.54081497
6MOS2.49069629
7ERN12.45775220
8KSR22.42476312
9TAOK12.36772451
10MAP3K92.35507882
11RIPK12.34960158
12MAP2K32.25273826
13STK392.13554455
14CDK192.08971463
15IRAK42.03448984
16MST1R1.96881273
17TRIB31.95304226
18SMG11.92183292
19MAP3K31.81312093
20PAK61.81117268
21EPHA41.78687477
22ERBB41.77040574
23PRKD31.74475615
24SIK11.72753837
25TGFBR11.72039955
26OXSR11.69829925
27AKT31.69252318
28SIK31.68223409
29TYRO31.66972082
30EPHB11.64839698
31EPHA21.64414769
32MAP3K131.62078145
33CDK121.60728392
34STK101.53363550
35RIPK41.45388549
36STK31.40945662
37IRAK31.38072112
38RAF11.35664806
39PDGFRA1.33430798
40ARAF1.31928010
41CLK11.28662942
42BMPR21.28596675
43MAPKAPK51.25343282
44MELK1.25120997
45CDK81.23809793
46PAK41.21854286
47PKN11.20896923
48PRKD21.20065709
49TRPM71.19889314
50MARK21.16081179
51STK381.15731301
52TGFBR21.13990985
53PRPF4B1.09332279
54PTK2B1.04977650
55EEF2K1.00397809
56CSNK1G11.00156835
57MAP3K80.98050209
58ZAP700.96164515
59FGFR20.95910505
60CSNK1G20.94689588
61FGR0.94524967
62MAPK120.93538962
63TAOK30.93221009
64ROCK20.92384739
65PIK3CG0.91113471
66BRAF0.90186503
67CSNK1G30.88558929
68SGK30.88198925
69MUSK0.87417693
70KSR10.87190368
71CSNK1A1L0.86719906
72FER0.86373663
73PIM20.84405115
74PDGFRB0.83527003
75RET0.83201614
76TTK0.82707895
77BCR0.80932151
78FLT30.80912936
79MET0.80811236
80MAP3K40.78989537
81PRKD10.78598359
82CSK0.76118255
83PLK40.75003999
84DYRK20.73632192
85PLK20.73407377
86MAPK130.73402621
87TTN0.73346357
88MAPK70.73170569
89GRK70.71986868
90CAMK1G0.70645345
91PAK20.70471686
92PTK60.69289422
93TESK10.67549880
94NTRK20.67129653
95HCK0.66028482
96CAMK2A0.65733274
97MTOR0.64934572
98ABL20.64929230
99MAP3K110.64652741
100STK110.64467184
101EPHB20.64398015
102MAP3K20.63792367
103MAP3K10.61801333
104MARK30.59313492
105NTRK10.59134111
106MAPKAPK30.58759747
107NEK60.58264535
108RPS6KA20.56482004
109TYK20.56349300
110CDK30.55773275
111CDK90.54628593
112JAK30.54487149
113PRKG20.53969200
114TAOK20.53632847
115CDC42BPA0.52585364
116CDK60.51204400
117HIPK20.50421467
118CSNK1D0.47910927
119ICK0.47846487
120WNK10.46342690
121FES0.46211419
122BMX0.45815959
123MAP3K70.44618097
124LMTK20.44182662
125JAK10.43887411
126PRKAA20.43777176
127PAK10.43359389
128MAP2K40.43211750
129PDPK10.42573040
130PRKCI0.42145088
131BLK0.42061971
132CDC70.42054218
133TAF10.41204928
134SGK4940.40452072
135SGK2230.40452072
136EPHA30.40102785
137MAPKAPK20.39761740
138ROCK10.38907150
139ABL10.38675216
140MAP2K10.38608875
141GRK50.38537910
142PAK30.37907948
143GSK3A0.37256717
144LIMK10.36936003
145PRKCH0.36559083
146WNK40.36258316
147CAMK1D0.36174458
148PDK10.35490246
149CHEK20.34857918
150NUAK10.34535842
151CDK150.32916526
152PTK20.32879712
153ILK0.32688090
154STK240.32327392
155CDK50.32118062

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043601.92261545
2Renal cell carcinoma_Homo sapiens_hsa052111.90853332
3Ether lipid metabolism_Homo sapiens_hsa005651.87825384
4Acute myeloid leukemia_Homo sapiens_hsa052211.79224687
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77958699
6Dorso-ventral axis formation_Homo sapiens_hsa043201.72367737
7Thyroid cancer_Homo sapiens_hsa052161.70443005
8Ovarian steroidogenesis_Homo sapiens_hsa049131.63466797
9Pancreatic cancer_Homo sapiens_hsa052121.60381330
10GnRH signaling pathway_Homo sapiens_hsa049121.59814416
11Dilated cardiomyopathy_Homo sapiens_hsa054141.51639618
12Neurotrophin signaling pathway_Homo sapiens_hsa047221.45218701
13Adherens junction_Homo sapiens_hsa045201.42379417
14Long-term depression_Homo sapiens_hsa047301.40444435
15TGF-beta signaling pathway_Homo sapiens_hsa043501.38035729
16MicroRNAs in cancer_Homo sapiens_hsa052061.35184560
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33460778
18VEGF signaling pathway_Homo sapiens_hsa043701.33191033
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32005843
20Ras signaling pathway_Homo sapiens_hsa040141.31131928
21ErbB signaling pathway_Homo sapiens_hsa040121.28872070
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28595320
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27707820
24ECM-receptor interaction_Homo sapiens_hsa045121.27110797
25Sphingolipid metabolism_Homo sapiens_hsa006001.26849820
26Hippo signaling pathway_Homo sapiens_hsa043901.26828089
27Glutamatergic synapse_Homo sapiens_hsa047241.26221019
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.25165213
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24589163
30Long-term potentiation_Homo sapiens_hsa047201.22448511
31Tight junction_Homo sapiens_hsa045301.19742060
32Choline metabolism in cancer_Homo sapiens_hsa052311.19528760
33Oxytocin signaling pathway_Homo sapiens_hsa049211.18459546
34Focal adhesion_Homo sapiens_hsa045101.18162527
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.16845761
36Serotonergic synapse_Homo sapiens_hsa047261.13846852
37Osteoclast differentiation_Homo sapiens_hsa043801.12965978
38Toxoplasmosis_Homo sapiens_hsa051451.11501383
39Inositol phosphate metabolism_Homo sapiens_hsa005621.11087302
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.10957193
41Wnt signaling pathway_Homo sapiens_hsa043101.10927790
42Glioma_Homo sapiens_hsa052141.10838748
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08971662
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08236586
45Salivary secretion_Homo sapiens_hsa049701.07329833
46Hedgehog signaling pathway_Homo sapiens_hsa043401.07041207
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05006362
48Phototransduction_Homo sapiens_hsa047441.04935241
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.04688986
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03771592
51Renin secretion_Homo sapiens_hsa049241.03415083
52Basal cell carcinoma_Homo sapiens_hsa052171.03269514
53cAMP signaling pathway_Homo sapiens_hsa040241.02836216
54Rap1 signaling pathway_Homo sapiens_hsa040151.02516239
55Colorectal cancer_Homo sapiens_hsa052101.01851539
56Olfactory transduction_Homo sapiens_hsa047401.01257009
57* MAPK signaling pathway_Homo sapiens_hsa040101.00679173
58Proteoglycans in cancer_Homo sapiens_hsa052050.99736749
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99697747
60Insulin signaling pathway_Homo sapiens_hsa049100.99108272
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98749336
62Melanogenesis_Homo sapiens_hsa049160.98456216
63Estrogen signaling pathway_Homo sapiens_hsa049150.98068693
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98040207
65Cholinergic synapse_Homo sapiens_hsa047250.97772074
66Endocytosis_Homo sapiens_hsa041440.96493957
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96100453
68B cell receptor signaling pathway_Homo sapiens_hsa046620.95959021
69Platelet activation_Homo sapiens_hsa046110.95434933
70Gap junction_Homo sapiens_hsa045400.95000755
71Non-small cell lung cancer_Homo sapiens_hsa052230.94912645
72Oocyte meiosis_Homo sapiens_hsa041140.94818359
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92942190
74Endometrial cancer_Homo sapiens_hsa052130.92837274
75Circadian entrainment_Homo sapiens_hsa047130.92602834
76Linoleic acid metabolism_Homo sapiens_hsa005910.92575516
77p53 signaling pathway_Homo sapiens_hsa041150.91759437
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89811952
79Gastric acid secretion_Homo sapiens_hsa049710.89619936
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88130521
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88099054
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86438069
83Notch signaling pathway_Homo sapiens_hsa043300.86263634
84Tuberculosis_Homo sapiens_hsa051520.84512557
85Dopaminergic synapse_Homo sapiens_hsa047280.84187656
86Circadian rhythm_Homo sapiens_hsa047100.83661487
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83292674
88Hepatitis B_Homo sapiens_hsa051610.80560873
89Chronic myeloid leukemia_Homo sapiens_hsa052200.80056721
90Apoptosis_Homo sapiens_hsa042100.80028715
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79455440
92T cell receptor signaling pathway_Homo sapiens_hsa046600.79280086
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78869291
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78490501
95Pathways in cancer_Homo sapiens_hsa052000.77512176
96Small cell lung cancer_Homo sapiens_hsa052220.77446689
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77444921
98HIF-1 signaling pathway_Homo sapiens_hsa040660.77288219
99Cell cycle_Homo sapiens_hsa041100.77049434
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.76831180
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76656579
102Prostate cancer_Homo sapiens_hsa052150.76257763
103Amoebiasis_Homo sapiens_hsa051460.75305030
104Prolactin signaling pathway_Homo sapiens_hsa049170.74339669
105Malaria_Homo sapiens_hsa051440.73679610
106Morphine addiction_Homo sapiens_hsa050320.73171737
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72783062
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72259596
109Chemokine signaling pathway_Homo sapiens_hsa040620.70833759
110Melanoma_Homo sapiens_hsa052180.70730142
111Shigellosis_Homo sapiens_hsa051310.70007352
112Amphetamine addiction_Homo sapiens_hsa050310.69747953
113Cocaine addiction_Homo sapiens_hsa050300.69507068
114Influenza A_Homo sapiens_hsa051640.68363864
115Basal transcription factors_Homo sapiens_hsa030220.68319647
116Calcium signaling pathway_Homo sapiens_hsa040200.68132618
117Prion diseases_Homo sapiens_hsa050200.68102128
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67843642
119TNF signaling pathway_Homo sapiens_hsa046680.67231615
120mTOR signaling pathway_Homo sapiens_hsa041500.67041685
121Bladder cancer_Homo sapiens_hsa052190.66321277
122Measles_Homo sapiens_hsa051620.66041758
123RNA degradation_Homo sapiens_hsa030180.65358436
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65244460
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65176564
126Leishmaniasis_Homo sapiens_hsa051400.64535172
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64035081
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63947076
129Salmonella infection_Homo sapiens_hsa051320.63455325
130Hepatitis C_Homo sapiens_hsa051600.63352188
131Synaptic vesicle cycle_Homo sapiens_hsa047210.62229262
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61038275
133FoxO signaling pathway_Homo sapiens_hsa040680.60997786
134Viral myocarditis_Homo sapiens_hsa054160.60942122
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60426164
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.59681262

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