DUSP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58456322
2vocalization behavior (GO:0071625)5.24265213
3neuron cell-cell adhesion (GO:0007158)5.21433059
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.90385565
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89979822
6synaptic vesicle exocytosis (GO:0016079)4.72238367
7synaptic vesicle maturation (GO:0016188)4.71273041
8cellular potassium ion homeostasis (GO:0030007)4.69324803
9sodium ion export (GO:0071436)4.66300915
10regulation of synaptic vesicle exocytosis (GO:2000300)4.63657436
11locomotory exploration behavior (GO:0035641)4.63025675
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58636864
13protein localization to synapse (GO:0035418)4.48175741
14glutamate secretion (GO:0014047)4.38466676
15regulation of glutamate receptor signaling pathway (GO:1900449)4.38018498
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.37604365
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.21988356
18presynaptic membrane organization (GO:0097090)4.16177692
19presynaptic membrane assembly (GO:0097105)4.10366521
20regulation of synaptic vesicle transport (GO:1902803)4.09572568
21dendritic spine morphogenesis (GO:0060997)4.05967604
22layer formation in cerebral cortex (GO:0021819)4.05633799
23neuron recognition (GO:0008038)4.01871001
24regulation of synapse structural plasticity (GO:0051823)3.98583020
25synaptic transmission, glutamatergic (GO:0035249)3.96066881
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.90969371
27neurotransmitter-gated ion channel clustering (GO:0072578)3.86808906
28regulation of neuronal synaptic plasticity (GO:0048168)3.86597809
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86126565
30glutamate receptor signaling pathway (GO:0007215)3.85347202
31exploration behavior (GO:0035640)3.85221050
32neurotransmitter secretion (GO:0007269)3.82302364
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.79355637
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77784178
35axonal fasciculation (GO:0007413)3.76946677
36neuronal action potential propagation (GO:0019227)3.76012212
37gamma-aminobutyric acid transport (GO:0015812)3.73097928
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.71951431
39neuron-neuron synaptic transmission (GO:0007270)3.69462601
40regulation of ARF protein signal transduction (GO:0032012)3.67311387
41postsynaptic membrane organization (GO:0001941)3.59048457
42dendrite morphogenesis (GO:0048813)3.54139113
43pyrimidine nucleobase catabolic process (GO:0006208)3.54100473
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50848679
45positive regulation of synapse maturation (GO:0090129)3.49034002
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45908315
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45390655
48cell migration in hindbrain (GO:0021535)3.44448234
49positive regulation of membrane potential (GO:0045838)3.38102609
50long-term memory (GO:0007616)3.36784288
51synapse assembly (GO:0007416)3.36006914
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35120838
53regulation of postsynaptic membrane potential (GO:0060078)3.33424747
54cell communication by electrical coupling (GO:0010644)3.32776432
55central nervous system projection neuron axonogenesis (GO:0021952)3.32568738
56regulation of dendritic spine morphogenesis (GO:0061001)3.31147107
57regulation of voltage-gated calcium channel activity (GO:1901385)3.30092409
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29647652
59L-amino acid import (GO:0043092)3.28200214
60transmission of nerve impulse (GO:0019226)3.26251908
61potassium ion homeostasis (GO:0055075)3.22693534
62auditory behavior (GO:0031223)3.21367811
63central nervous system myelination (GO:0022010)3.20808591
64axon ensheathment in central nervous system (GO:0032291)3.20808591
65regulation of neurotransmitter secretion (GO:0046928)3.20719868
66cerebellar granule cell differentiation (GO:0021707)3.18763962
67adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.17759728
68dopamine receptor signaling pathway (GO:0007212)3.16454700
69amino acid import (GO:0043090)3.14294870
70neurotransmitter transport (GO:0006836)3.12797603
71cerebral cortex radially oriented cell migration (GO:0021799)3.10298670
72neuromuscular synaptic transmission (GO:0007274)3.08719957
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.07938058
74cell differentiation in hindbrain (GO:0021533)3.06589517
75positive regulation of synapse assembly (GO:0051965)3.06515037
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.05341486
77regulation of synaptic plasticity (GO:0048167)3.04974753
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03544262
79cytoskeletal anchoring at plasma membrane (GO:0007016)3.03258474
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02723096
81positive regulation of dendritic spine morphogenesis (GO:0061003)3.00216183
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00211747
83proline transport (GO:0015824)3.00077972
84establishment of mitochondrion localization (GO:0051654)2.99297381
85synaptic vesicle endocytosis (GO:0048488)2.99139326
86long-term synaptic potentiation (GO:0060291)2.97875394
87membrane hyperpolarization (GO:0060081)2.97394076
88mating behavior (GO:0007617)2.95372256
89cellular sodium ion homeostasis (GO:0006883)2.95273704
90potassium ion import (GO:0010107)2.94902335
91neuronal ion channel clustering (GO:0045161)2.93833675
92response to auditory stimulus (GO:0010996)2.93637213
93synapse organization (GO:0050808)2.92776432
94activation of protein kinase A activity (GO:0034199)2.92159179
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92074468
96regulation of synapse maturation (GO:0090128)2.91734447
97neuromuscular process controlling balance (GO:0050885)2.91691305
98nucleobase catabolic process (GO:0046113)2.91147486
99regulation of neurotransmitter transport (GO:0051588)2.90426646
100membrane depolarization (GO:0051899)2.89779299
101regulation of vesicle fusion (GO:0031338)2.89277910
102regulation of dendritic spine development (GO:0060998)2.88622436
103positive regulation of neurotransmitter secretion (GO:0001956)2.87866771
104negative regulation of dendrite morphogenesis (GO:0050774)2.85268125
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82802749
106learning (GO:0007612)2.82767585
107regulation of neurotransmitter levels (GO:0001505)2.82577997
108behavioral fear response (GO:0001662)2.82228715
109behavioral defense response (GO:0002209)2.82228715
110positive regulation of neurotransmitter transport (GO:0051590)2.81088643
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.80991854
112mitochondrion transport along microtubule (GO:0047497)2.80991854
113membrane depolarization during action potential (GO:0086010)2.79825910
114dendrite development (GO:0016358)2.79156879
115dendritic spine organization (GO:0097061)2.78886324
116negative regulation of microtubule polymerization (GO:0031115)2.78726877
117regulation of synaptic transmission (GO:0050804)2.78526678
118neuromuscular process controlling posture (GO:0050884)2.78181918
119cell communication involved in cardiac conduction (GO:0086065)2.77860410
120positive regulation of dendritic spine development (GO:0060999)2.76209236
121regulation of synaptic transmission, GABAergic (GO:0032228)2.76060810
122G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75900621
123organelle transport along microtubule (GO:0072384)2.74413046
124cerebellar Purkinje cell layer development (GO:0021680)2.73504712
125cerebellar Purkinje cell differentiation (GO:0021702)2.72891434
126mechanosensory behavior (GO:0007638)2.72842575
127prepulse inhibition (GO:0060134)2.72712886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82194136
2GBX2_23144817_ChIP-Seq_PC3_Human3.52661680
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98137424
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92964005
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91742667
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83353603
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66888997
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66888997
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.60880999
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52520006
11REST_21632747_ChIP-Seq_MESCs_Mouse2.49235178
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46381840
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45645448
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42137616
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38407676
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35028532
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28154262
18DROSHA_22980978_ChIP-Seq_HELA_Human2.26377245
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.25478958
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.25172758
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23227897
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21315743
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.17557242
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.04128456
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03494351
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.03226542
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00651736
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99585473
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95837596
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78963952
31LXR_22292898_ChIP-Seq_THP-1_Human1.78797532
32* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78431267
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75474664
34AR_21572438_ChIP-Seq_LNCaP_Human1.71399292
35* CTCF_27219007_Chip-Seq_Bcells_Human1.68912834
36TAF15_26573619_Chip-Seq_HEK293_Human1.67822842
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66112250
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62754277
39KDM2B_26808549_Chip-Seq_DND41_Human1.60045268
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.59733633
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56917812
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56907146
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55536875
44SMAD4_21799915_ChIP-Seq_A2780_Human1.55355716
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54085580
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.52812040
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50076913
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44745853
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44537379
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43474233
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42067508
52P300_19829295_ChIP-Seq_ESCs_Human1.39444806
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38835170
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36850730
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.36466297
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.36081676
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35792137
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34321679
59CREB1_26743006_Chip-Seq_LNCaP_Human1.33452564
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.32354677
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.32105197
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.29787795
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.29360763
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29234526
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28959499
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28107303
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.27962442
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26572049
69RNF2_27304074_Chip-Seq_NSC_Mouse1.26342172
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.24075978
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23876877
72ZNF274_21170338_ChIP-Seq_K562_Hela1.23735783
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22611250
74IGF1R_20145208_ChIP-Seq_DFB_Human1.20904868
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20899355
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19589057
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19470625
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18838472
79AHR_22903824_ChIP-Seq_MCF-7_Human1.18556105
80AR_25329375_ChIP-Seq_VCAP_Human1.18516006
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18453582
82STAT3_23295773_ChIP-Seq_U87_Human1.18436989
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18093954
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17533113
85SMC4_20622854_ChIP-Seq_HELA_Human1.17185325
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.16939904
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.16864735
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15452168
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15354227
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15081242
91P68_20966046_ChIP-Seq_HELA_Human1.14811625
92AR_19668381_ChIP-Seq_PC3_Human1.14632668
93OCT4_19829295_ChIP-Seq_ESCs_Human1.13606365
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13117318
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12326722
96TCF7_22412390_ChIP-Seq_EML_Mouse1.10270557
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09285689
98* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08730052
99* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07367211
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06732864
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06075608
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05423843
103* TCF4_23295773_ChIP-Seq_U87_Human1.05083640
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03200719
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02536753
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02197594
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02025135
108RACK7_27058665_Chip-Seq_MCF-7_Human1.01685729
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.01117300
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00736536
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99884373
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99884373
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.99655863
114ER_23166858_ChIP-Seq_MCF-7_Human0.99509999
115RUNX2_22187159_ChIP-Seq_PCA_Human0.99245972
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99214007
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98724083
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98600300
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97168956
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97112666
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.96230355
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.95911197
123* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95051515
124* KDM2B_26808549_Chip-Seq_K562_Human0.94666123
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.94069484
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92940658
127* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91871480
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91585250
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90846986
130KLF4_19829295_ChIP-Seq_ESCs_Human0.90196478
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89842369
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89224498
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.89061905
134VDR_22108803_ChIP-Seq_LS180_Human0.88166637
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.87184220
136TP53_18474530_ChIP-ChIP_U2OS_Human0.86990996
137* DPY_21335234_ChIP-Seq_ESCs_Mouse0.86404728
138* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85990792
139FUS_26573619_Chip-Seq_HEK293_Human0.85939830
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.85798114
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85559524
142* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85270865
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84068823
144SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82407812
145SOX3_22085726_ChIP-Seq_NPCs_Mouse0.77466921
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75552647
147NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75314419
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.75088640
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74925602
150SA1_27219007_Chip-Seq_Bcells_Human0.74358954
151TP53_23651856_ChIP-Seq_MEFs_Mouse0.74121250
152SMAD4_21741376_ChIP-Seq_ESCs_Human0.73777225
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73718247
154RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72551718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64156870
2MP0003880_abnormal_central_pattern4.39903524
3MP0004270_analgesia3.80736565
4MP0003635_abnormal_synaptic_transmissio3.76476621
5MP0002063_abnormal_learning/memory/cond3.12764417
6MP0009745_abnormal_behavioral_response3.06720164
7MP0005423_abnormal_somatic_nervous3.01727049
8MP0002064_seizures2.85865682
9MP0009046_muscle_twitch2.72053806
10MP0001968_abnormal_touch/_nociception2.69088466
11MP0002734_abnormal_mechanical_nocicepti2.62312737
12MP0002572_abnormal_emotion/affect_behav2.62008082
13MP0001486_abnormal_startle_reflex2.45776467
14MP0000778_abnormal_nervous_system2.44266566
15MP0002272_abnormal_nervous_system2.41348503
16MP0003123_paternal_imprinting2.40015205
17MP0002735_abnormal_chemical_nociception2.34685520
18MP0002822_catalepsy2.25549656
19MP0002736_abnormal_nociception_after2.14433966
20MP0002184_abnormal_innervation2.07288266
21MP0001440_abnormal_grooming_behavior2.03631851
22MP0002733_abnormal_thermal_nociception1.89490624
23MP0002067_abnormal_sensory_capabilities1.89071454
24MP0006276_abnormal_autonomic_nervous1.86441925
25MP0002557_abnormal_social/conspecific_i1.84508292
26MP0001970_abnormal_pain_threshold1.83744263
27MP0008569_lethality_at_weaning1.79400175
28MP0004811_abnormal_neuron_physiology1.78871563
29MP0004924_abnormal_behavior1.75313993
30MP0005386_behavior/neurological_phenoty1.75313993
31MP0001501_abnormal_sleep_pattern1.71224141
32MP0001984_abnormal_olfaction1.68894254
33MP0009780_abnormal_chondrocyte_physiolo1.66181123
34MP0001529_abnormal_vocalization1.66092281
35MP0003787_abnormal_imprinting1.64438845
36MP0004858_abnormal_nervous_system1.63829485
37MP0000955_abnormal_spinal_cord1.62865779
38MP0002882_abnormal_neuron_morphology1.59609312
39MP0005646_abnormal_pituitary_gland1.58168923
40MP0005551_abnormal_eye_electrophysiolog1.57100498
41MP0004885_abnormal_endolymph1.54968595
42MP0003329_amyloid_beta_deposits1.51513814
43MP0001188_hyperpigmentation1.48221818
44MP0005645_abnormal_hypothalamus_physiol1.45439635
45MP0000751_myopathy1.44768868
46MP0002909_abnormal_adrenal_gland1.44706501
47MP0002066_abnormal_motor_capabilities/c1.38173735
48MP0005394_taste/olfaction_phenotype1.34085245
49MP0005499_abnormal_olfactory_system1.34085245
50MP0001502_abnormal_circadian_rhythm1.30224890
51MP0001905_abnormal_dopamine_level1.28170168
52MP0003122_maternal_imprinting1.24868884
53MP0002152_abnormal_brain_morphology1.23184804
54MP0004742_abnormal_vestibular_system1.21920896
55MP0001348_abnormal_lacrimal_gland1.21313573
56MP0003879_abnormal_hair_cell1.20787993
57MP0004145_abnormal_muscle_electrophysio1.20367968
58MP0004142_abnormal_muscle_tone1.20284091
59MP0003633_abnormal_nervous_system1.14961686
60MP0002837_dystrophic_cardiac_calcinosis1.13327943
61MP0002229_neurodegeneration1.11926809
62MP0004510_myositis1.10132039
63MP0000604_amyloidosis1.06365833
64MP0004085_abnormal_heartbeat1.05816272
65MP0004130_abnormal_muscle_cell1.05241592
66MP0003634_abnormal_glial_cell1.04779214
67MP0002249_abnormal_larynx_morphology1.04150879
68MP0002752_abnormal_somatic_nervous1.03964101
69MP0000631_abnormal_neuroendocrine_gland1.03290348
70MP0003631_nervous_system_phenotype1.02809483
71MP0003283_abnormal_digestive_organ0.97211278
72MP0000920_abnormal_myelination0.97035490
73MP0001177_atelectasis0.96834561
74MP0006072_abnormal_retinal_apoptosis0.95350310
75MP0000566_synostosis0.94727968
76MP0008789_abnormal_olfactory_epithelium0.93832387
77MP0010386_abnormal_urinary_bladder0.93547446
78MP0003137_abnormal_impulse_conducting0.91071911
79MP0003121_genomic_imprinting0.89456500
80MP0002069_abnormal_eating/drinking_beha0.89451953
81MP0005409_darkened_coat_color0.88901947
82MP0001963_abnormal_hearing_physiology0.86663517
83MP0003690_abnormal_glial_cell0.86203170
84MP0000569_abnormal_digit_pigmentation0.84864946
85MP0003861_abnormal_nervous_system0.83616056
86MP0003172_abnormal_lysosome_physiology0.83535214
87MP0002090_abnormal_vision0.81851299
88MP0005253_abnormal_eye_physiology0.81332663
89MP0004215_abnormal_myocardial_fiber0.79578783
90MP0002638_abnormal_pupillary_reflex0.78852748
91MP0003632_abnormal_nervous_system0.75526843
92MP0005187_abnormal_penis_morphology0.75178326
93MP0002089_abnormal_postnatal_growth/wei0.72422631
94MP0002751_abnormal_autonomic_nervous0.71499919
95MP0001346_abnormal_lacrimal_gland0.70676942
96MP0000013_abnormal_adipose_tissue0.69536703
97MP0008872_abnormal_physiological_respon0.69289316
98MP0005171_absent_coat_pigmentation0.69064873
99MP0005195_abnormal_posterior_eye0.68098126
100MP0001485_abnormal_pinna_reflex0.67918712
101MP0005535_abnormal_body_temperature0.66827803
102MP0000026_abnormal_inner_ear0.64295979
103MP0001943_abnormal_respiration0.64284588
104MP0001299_abnormal_eye_distance/0.63723405
105MP0005448_abnormal_energy_balance0.63055116
106MP0010768_mortality/aging0.62415216
107MP0008874_decreased_physiological_sensi0.62336860
108MP0005620_abnormal_muscle_contractility0.61957500
109MP0008961_abnormal_basal_metabolism0.61669501
110MP0006292_abnormal_olfactory_placode0.61586671
111MP0004484_altered_response_of0.59842441
112MP0003646_muscle_fatigue0.57594249
113MP0003075_altered_response_to0.57070714
114MP0010769_abnormal_survival0.56951521
115MP0002082_postnatal_lethality0.56391595
116MP0010770_preweaning_lethality0.56391595
117MP0002081_perinatal_lethality0.51268346
118MP0001944_abnormal_pancreas_morphology0.50331235
119MP0003956_abnormal_body_size0.50292245
120MP0000579_abnormal_nail_morphology0.49119413
121MP0003948_abnormal_gas_homeostasis0.47788131
122MP0000537_abnormal_urethra_morphology0.47557740

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.93321174
2Myokymia (HP:0002411)5.60282793
3Focal seizures (HP:0007359)4.78812346
4Epileptic encephalopathy (HP:0200134)4.34107578
5Visual hallucinations (HP:0002367)4.23326639
6Atonic seizures (HP:0010819)4.01064913
7Progressive cerebellar ataxia (HP:0002073)3.89114070
8Febrile seizures (HP:0002373)3.86624648
9Broad-based gait (HP:0002136)3.41679577
10Hyperventilation (HP:0002883)3.40875425
11Ankle clonus (HP:0011448)3.39555788
12Absence seizures (HP:0002121)3.25745858
13Supranuclear gaze palsy (HP:0000605)3.22780758
14Limb dystonia (HP:0002451)3.08555975
15Action tremor (HP:0002345)3.07595424
16Generalized tonic-clonic seizures (HP:0002069)3.05368540
17Dialeptic seizures (HP:0011146)3.04891910
18Annular pancreas (HP:0001734)3.01390946
19Amblyopia (HP:0000646)2.97140212
20Neuronal loss in central nervous system (HP:0002529)2.77917828
21Poor eye contact (HP:0000817)2.76477872
22Anxiety (HP:0000739)2.72645124
23Depression (HP:0000716)2.69976522
24Gaze-evoked nystagmus (HP:0000640)2.69596065
25Drooling (HP:0002307)2.68449531
26Excessive salivation (HP:0003781)2.68449531
27Mutism (HP:0002300)2.66855291
28Abnormal eating behavior (HP:0100738)2.66622149
29Truncal ataxia (HP:0002078)2.66194896
30Peripheral hypomyelination (HP:0007182)2.65349585
31Abnormality of the corticospinal tract (HP:0002492)2.62601554
32Dysdiadochokinesis (HP:0002075)2.61805419
33Impaired vibration sensation in the lower limbs (HP:0002166)2.61543389
34Spastic gait (HP:0002064)2.61513576
35Lower limb amyotrophy (HP:0007210)2.57981063
36Absent speech (HP:0001344)2.55312067
37Urinary bladder sphincter dysfunction (HP:0002839)2.53609162
38Dysmetria (HP:0001310)2.52349033
39Aplasia/Hypoplasia of the brainstem (HP:0007362)2.48692544
40Hypoplasia of the brainstem (HP:0002365)2.48692544
41Epileptiform EEG discharges (HP:0011182)2.47449486
42Impaired social interactions (HP:0000735)2.47224434
43Abnormal social behavior (HP:0012433)2.47224434
44Progressive inability to walk (HP:0002505)2.46354921
45Fetal akinesia sequence (HP:0001989)2.45893312
46Status epilepticus (HP:0002133)2.45770093
47Abnormality of the lower motor neuron (HP:0002366)2.45143168
48Pheochromocytoma (HP:0002666)2.43838674
49EEG with generalized epileptiform discharges (HP:0011198)2.43791305
50Neurofibrillary tangles (HP:0002185)2.40370977
51Obstructive sleep apnea (HP:0002870)2.35114750
52Hypsarrhythmia (HP:0002521)2.34766852
53Termporal pattern (HP:0011008)2.33600533
54Insidious onset (HP:0003587)2.33600533
55Urinary urgency (HP:0000012)2.33579019
56Scanning speech (HP:0002168)2.33291278
57Tetraplegia (HP:0002445)2.32896841
58Hemiplegia (HP:0002301)2.32865250
59Polyphagia (HP:0002591)2.32067088
60Apathy (HP:0000741)2.31051644
61Amyotrophic lateral sclerosis (HP:0007354)2.30211037
62Torticollis (HP:0000473)2.29533612
63Central scotoma (HP:0000603)2.28499026
64Spinal canal stenosis (HP:0003416)2.28352164
65Hemiparesis (HP:0001269)2.28070938
66Akinesia (HP:0002304)2.26312365
67Bronchomalacia (HP:0002780)2.24720417
68Clonus (HP:0002169)2.24561155
69Stereotypic behavior (HP:0000733)2.24331740
70Cerebral inclusion bodies (HP:0100314)2.24316247
71Lower limb muscle weakness (HP:0007340)2.21988332
72Gait imbalance (HP:0002141)2.21869026
73Cerebral hypomyelination (HP:0006808)2.20522062
74Inability to walk (HP:0002540)2.16964500
75Postural instability (HP:0002172)2.16879841
76Agitation (HP:0000713)2.15618461
77Focal dystonia (HP:0004373)2.14410741
78Hypercortisolism (HP:0001578)2.14330797
79Genetic anticipation (HP:0003743)2.12934998
80Prolonged QT interval (HP:0001657)2.12271431
81Sleep apnea (HP:0010535)2.11712703
82Rapidly progressive (HP:0003678)2.11075959
83Hyperthyroidism (HP:0000836)2.10367099
84Rigidity (HP:0002063)2.07980145
85Failure to thrive in infancy (HP:0001531)2.07171387
86Lissencephaly (HP:0001339)2.06930768
87Intention tremor (HP:0002080)2.05661460
88Diminished motivation (HP:0000745)2.05582860
89Retinal dysplasia (HP:0007973)2.04263636
90Hyperacusis (HP:0010780)2.01398001
91Megalencephaly (HP:0001355)2.00015028
92Protruding tongue (HP:0010808)1.98909588
93Specific learning disability (HP:0001328)1.98489795
94Neuroendocrine neoplasm (HP:0100634)1.93660935
95Turricephaly (HP:0000262)1.93174465
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93060204
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.93060204
98Abnormal EKG (HP:0003115)1.92815604
99Impaired smooth pursuit (HP:0007772)1.91898279
100Bradykinesia (HP:0002067)1.90544222
101Papilledema (HP:0001085)1.90312452
102Pointed chin (HP:0000307)1.89840192
103Spastic tetraparesis (HP:0001285)1.89120895
104Generalized myoclonic seizures (HP:0002123)1.88846000
105Lower limb asymmetry (HP:0100559)1.88213188
106Distal upper limb amyotrophy (HP:0007149)1.87829654
107Upper limb amyotrophy (HP:0009129)1.87829654
108Foot dorsiflexor weakness (HP:0009027)1.87258190
109Hyperparathyroidism (HP:0000843)1.86980967
110Abnormality of salivation (HP:0100755)1.86299797
111Abnormality of binocular vision (HP:0011514)1.85997326
112Diplopia (HP:0000651)1.85997326
113Abnormality of the aortic arch (HP:0012303)1.85957724
114Ulnar claw (HP:0001178)1.85416472
115Blue irides (HP:0000635)1.85410698
116Incomplete penetrance (HP:0003829)1.85216986
117Craniofacial dystonia (HP:0012179)1.84678585
118Hypoventilation (HP:0002791)1.84189628
119Thickened helices (HP:0000391)1.83193875
120Abnormal hair whorl (HP:0010721)1.83086891
121Ventricular fibrillation (HP:0001663)1.82511337
122Shoulder girdle muscle weakness (HP:0003547)1.80364436
123Morphological abnormality of the pyramidal tract (HP:0002062)1.79505559
124Delusions (HP:0000746)1.79333827
125Pachygyria (HP:0001302)1.79213142
126Impaired vibratory sensation (HP:0002495)1.78622287
127Growth hormone excess (HP:0000845)1.78538460
128Abnormality of ocular smooth pursuit (HP:0000617)1.78296677
129Hammertoe (HP:0001765)1.76941564
130Hand muscle atrophy (HP:0009130)1.76588793
131Abnormality of the foot musculature (HP:0001436)1.75696643
132Exotropia (HP:0000577)1.72083508
133Hepatoblastoma (HP:0002884)1.70904101
134Insomnia (HP:0100785)1.69770297
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69250690
136Congenital stationary night blindness (HP:0007642)1.66717373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.89146572
2EPHA43.45651727
3NTRK33.24692091
4CASK2.82689564
5MAP3K92.72503154
6MAP3K42.61769133
7MINK12.54926631
8MAP2K72.42717789
9RIPK12.39997559
10DAPK22.25511104
11NTRK22.24146387
12PRPF4B2.08406383
13PAK62.03974447
14PNCK1.89632143
15MAPK131.86957268
16SIK11.75996736
17CDK51.54498047
18UHMK11.51418423
19PHKG21.49044616
20PHKG11.49044616
21MAP2K41.49022974
22KSR11.48345586
23SGK4941.45422250
24SGK2231.45422250
25MAP3K121.43434920
26TRIB31.41971645
27PLK21.38923770
28TNIK1.38510481
29PRKD31.34823020
30NTRK11.30006084
31CAMKK11.29193235
32CDK191.25956450
33GRK51.25470587
34SIK21.25401757
35SGK21.21096316
36DYRK21.20575524
37KSR21.18135628
38PRKCG1.12317083
39OXSR11.10575216
40CSNK1G21.08306021
41CAMK2A1.07505215
42MAP3K111.04610087
43DAPK11.03194702
44TYRO31.01641077
45TAOK20.97273569
46BCR0.96801735
47MAPK120.95810251
48CAMK2B0.95687355
49PINK10.95300655
50FES0.94619520
51PKN10.94138766
52SGK30.91903073
53CAMKK20.91427489
54ERBB30.90786098
55MARK20.90390376
56PAK30.89713682
57DYRK1A0.88010327
58CDK180.86656299
59MAPK150.86097564
60CDK140.83413899
61CDK150.83163612
62EEF2K0.81781043
63TAOK10.81020327
64RIPK40.79684072
65CDK120.77155403
66PRKCH0.76707190
67ARAF0.74887788
68LIMK10.73806209
69STK390.72642581
70MAP3K20.72231336
71CSNK1G30.71690956
72AKT30.71633299
73CDK11A0.71163204
74CAMK10.71158909
75STK110.70424919
76BMPR20.68236584
77SGK10.67526060
78DYRK1B0.67075949
79STK380.66692412
80PRKCE0.66484318
81CAMK1G0.65677180
82CSNK1A1L0.65375526
83CAMK2D0.65016279
84IRAK20.64878944
85CAMK1D0.64281540
86WNK30.62378366
87BMPR1B0.62096716
88LATS20.61793055
89ROCK20.61441861
90DMPK0.60869148
91GRK70.60584300
92PRKCZ0.59628990
93RET0.59427048
94ALK0.58998193
95MAP3K10.58789498
96PTK2B0.58149274
97CAMK40.57897912
98WNK10.57603662
99HIPK20.55947887
100RPS6KA20.55895347
101TNK20.54743090
102PDK10.54219306
103PDPK10.54062810
104CAMK2G0.53918616
105MAP2K60.53670703
106SIK30.52960254
107NME10.52698974
108BRAF0.52488330
109ROCK10.50918239
110FGFR20.50406697
111* MAPK80.47253700
112ERBB20.46086774
113NEK60.45827266
114BRD40.45360460
115TESK10.44950281
116ADRBK10.44534357
117RPS6KA30.44127984
118PRKD20.44107374
119PRKAA10.43729511
120LMTK20.43711387
121DAPK30.41813418
122MAPK40.40874990
123MAP2K10.40196611
124FGR0.40107963
125MAPK100.39806128
126ICK0.39078503
127MTOR0.37488908
128BRSK10.35469874

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.49171369
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18385142
3Olfactory transduction_Homo sapiens_hsa047402.75012586
4GABAergic synapse_Homo sapiens_hsa047272.67486364
5Circadian entrainment_Homo sapiens_hsa047132.64270003
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63422042
7Glutamatergic synapse_Homo sapiens_hsa047242.51498208
8Morphine addiction_Homo sapiens_hsa050322.49380022
9Long-term potentiation_Homo sapiens_hsa047202.33492997
10Amphetamine addiction_Homo sapiens_hsa050312.21194947
11Dopaminergic synapse_Homo sapiens_hsa047282.17313248
12Cholinergic synapse_Homo sapiens_hsa047251.96847217
13Phototransduction_Homo sapiens_hsa047441.96803296
14Salivary secretion_Homo sapiens_hsa049701.87586112
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86789386
16Serotonergic synapse_Homo sapiens_hsa047261.84133900
17Insulin secretion_Homo sapiens_hsa049111.83032401
18Taste transduction_Homo sapiens_hsa047421.77415438
19Long-term depression_Homo sapiens_hsa047301.72725367
20Cocaine addiction_Homo sapiens_hsa050301.71465561
21Renin secretion_Homo sapiens_hsa049241.63877616
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63115304
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62513813
24Axon guidance_Homo sapiens_hsa043601.61077024
25Gastric acid secretion_Homo sapiens_hsa049711.60554269
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59370063
27Oxytocin signaling pathway_Homo sapiens_hsa049211.56698696
28Collecting duct acid secretion_Homo sapiens_hsa049661.53261517
29Gap junction_Homo sapiens_hsa045401.43397923
30Calcium signaling pathway_Homo sapiens_hsa040201.38153510
31GnRH signaling pathway_Homo sapiens_hsa049121.36158617
32cAMP signaling pathway_Homo sapiens_hsa040241.21188026
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18539757
34Cardiac muscle contraction_Homo sapiens_hsa042601.17260754
35ErbB signaling pathway_Homo sapiens_hsa040121.12326173
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10734083
37Vitamin B6 metabolism_Homo sapiens_hsa007501.09274002
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09107224
39Type II diabetes mellitus_Homo sapiens_hsa049301.07230877
40Estrogen signaling pathway_Homo sapiens_hsa049151.05742242
41Vibrio cholerae infection_Homo sapiens_hsa051101.04997460
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02561700
43Melanogenesis_Homo sapiens_hsa049161.00724120
44Glioma_Homo sapiens_hsa052141.00357513
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00304873
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98196884
47Dilated cardiomyopathy_Homo sapiens_hsa054140.97117275
48Bile secretion_Homo sapiens_hsa049760.93959447
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.90150105
50Dorso-ventral axis formation_Homo sapiens_hsa043200.83801446
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81360259
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80240426
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80050304
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78981918
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76894956
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76159450
57* MAPK signaling pathway_Homo sapiens_hsa040100.75873632
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.73965897
59Pancreatic secretion_Homo sapiens_hsa049720.73896616
60Ras signaling pathway_Homo sapiens_hsa040140.70434171
61Endometrial cancer_Homo sapiens_hsa052130.69320555
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68074644
63Notch signaling pathway_Homo sapiens_hsa043300.67529625
64Choline metabolism in cancer_Homo sapiens_hsa052310.67314262
65Renal cell carcinoma_Homo sapiens_hsa052110.65809291
66AMPK signaling pathway_Homo sapiens_hsa041520.64236074
67Alcoholism_Homo sapiens_hsa050340.63097571
68Oocyte meiosis_Homo sapiens_hsa041140.62969189
69Alzheimers disease_Homo sapiens_hsa050100.61554661
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60847492
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59037282
72Prolactin signaling pathway_Homo sapiens_hsa049170.58738242
73Wnt signaling pathway_Homo sapiens_hsa043100.57945667
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57913383
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.57670541
76Rap1 signaling pathway_Homo sapiens_hsa040150.56650139
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56416946
78Endocytosis_Homo sapiens_hsa041440.55308315
79Thyroid hormone synthesis_Homo sapiens_hsa049180.53575034
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53198304
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51496952
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.49389249
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49350936
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48625485
85Oxidative phosphorylation_Homo sapiens_hsa001900.48507361
86VEGF signaling pathway_Homo sapiens_hsa043700.48416429
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47611390
88Colorectal cancer_Homo sapiens_hsa052100.47411319
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46502992
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46326718
91Glucagon signaling pathway_Homo sapiens_hsa049220.43714042
92Circadian rhythm_Homo sapiens_hsa047100.42778162
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42445628
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42386169
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41921426
96Ovarian steroidogenesis_Homo sapiens_hsa049130.41612040
97Prion diseases_Homo sapiens_hsa050200.41424391
98Parkinsons disease_Homo sapiens_hsa050120.41030645
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40751552
100Tight junction_Homo sapiens_hsa045300.39898130
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39326208
102Insulin signaling pathway_Homo sapiens_hsa049100.35826341
103Hippo signaling pathway_Homo sapiens_hsa043900.35486086
104Inositol phosphate metabolism_Homo sapiens_hsa005620.35301844
105Non-small cell lung cancer_Homo sapiens_hsa052230.34435330
106Hedgehog signaling pathway_Homo sapiens_hsa043400.34334817
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34322768
108FoxO signaling pathway_Homo sapiens_hsa040680.34202048
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33707346
110Chemokine signaling pathway_Homo sapiens_hsa040620.33376908
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.33034834
112Type I diabetes mellitus_Homo sapiens_hsa049400.31764772
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31048438
114mTOR signaling pathway_Homo sapiens_hsa041500.30684783

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »