ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	postsynaptic membrane organization (GO:0001941)	5.44053694
2	histone H3-K9 methylation (GO:0051567)	4.44019615
3	neuron recognition (GO:0008038)	4.39019648
4	positive regulation of RNA splicing (GO:0033120)	4.05460638
5	synaptic vesicle exocytosis (GO:0016079)	4.05441083
6	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.96225606
7	urinary tract smooth muscle contraction (GO:0014848)	3.94622879
8	protein carboxylation (GO:0018214)	3.91188154
9	peptidyl-glutamic acid carboxylation (GO:0017187)	3.91188154
10	heart valve formation (GO:0003188)	3.90205499
11	layer formation in cerebral cortex (GO:0021819)	3.89536509
12	alternative mRNA splicing, via spliceosome (GO:0000380)	3.87853054
13	histone H3-K9 modification (GO:0061647)	3.81940889
14	negative regulation of astrocyte differentiation (GO:0048712)	3.81791305
15	protein insertion into membrane (GO:0051205)	3.77903417
16	sequestering of actin monomers (GO:0042989)	3.76187019
17	glutamate secretion (GO:0014047)	3.66218308
18	behavioral response to nicotine (GO:0035095)	3.53691776
19	positive regulation of synapse assembly (GO:0051965)	3.50975375
20	metanephric mesenchyme development (GO:0072075)	3.50864719
21	negative regulation of membrane potential (GO:0045837)	3.37486320
22	cornea development in camera-type eye (GO:0061303)	3.30858135
23	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.28788093
24	auditory behavior (GO:0031223)	3.28479373
25	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.20532716
26	cellular response to cholesterol (GO:0071397)	3.19224685
27	spinal cord association neuron differentiation (GO:0021527)	3.17586583
28	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.16218027
29	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.11714662
30	regulation of skeletal muscle contraction (GO:0014819)	3.11643223
31	intraspecies interaction between organisms (GO:0051703)	3.05489052
32	social behavior (GO:0035176)	3.05489052
33	dopamine biosynthetic process (GO:0042416)	3.03259192
34	dendritic spine morphogenesis (GO:0060997)	2.99758851
35	regulation of gene silencing by miRNA (GO:0060964)	2.99391169
36	regulation of gene silencing by RNA (GO:0060966)	2.99391169
37	regulation of posttranscriptional gene silencing (GO:0060147)	2.99391169
38	kidney mesenchyme development (GO:0072074)	2.99096598
39	mRNA splice site selection (GO:0006376)	2.98650857
40	axon extension (GO:0048675)	2.96179971
41	response to methylmercury (GO:0051597)	2.96111661
42	lateral ventricle development (GO:0021670)	2.95024267
43	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.94218204
44	transmission of nerve impulse (GO:0019226)	2.92999444
45	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.91475708
46	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.90633109
47	DNA strand renaturation (GO:0000733)	2.89060419
48	negative regulation of gene silencing (GO:0060969)	2.88875589
49	dentate gyrus development (GO:0021542)	2.87731066
50	skeletal muscle organ development (GO:0060538)	2.87715914
51	coenzyme A biosynthetic process (GO:0015937)	2.87229926
52	cellular potassium ion homeostasis (GO:0030007)	2.87032762
53	fatty acid elongation (GO:0030497)	2.85898269
54	regulation of synapse structural plasticity (GO:0051823)	2.84575068
55	DNA damage induced protein phosphorylation (GO:0006975)	2.83665994
56	generation of neurons (GO:0048699)	2.81042770
57	forebrain morphogenesis (GO:0048853)	2.75366389
58	Notch signaling involved in heart development (GO:0061314)	2.75264975
59	negative regulation of glial cell differentiation (GO:0045686)	2.75255334
60	coenzyme A metabolic process (GO:0015936)	2.74205242
61	synaptic vesicle maturation (GO:0016188)	2.73247820
62	chondroitin sulfate catabolic process (GO:0030207)	2.71528795
63	neuromuscular junction development (GO:0007528)	2.70378462
64	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.69924294
65	left/right pattern formation (GO:0060972)	2.67229348
66	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.62223037
67	behavioral defense response (GO:0002209)	2.61385183
68	behavioral fear response (GO:0001662)	2.61385183
69	dopaminergic neuron differentiation (GO:0071542)	2.59042597
70	negative regulation of cell aging (GO:0090344)	2.58309610
71	microtubule nucleation (GO:0007020)	2.57238800
72	synaptic transmission, cholinergic (GO:0007271)	2.56453368
73	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.55685019
74	regulation of dopamine secretion (GO:0014059)	2.55480496
75	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.54642211
76	mesenchyme morphogenesis (GO:0072132)	2.54158655
77	peptidyl-lysine dimethylation (GO:0018027)	2.53564062
78	central nervous system projection neuron axonogenesis (GO:0021952)	2.52484659
79	mechanosensory behavior (GO:0007638)	2.51408003
80	regulation of synapse assembly (GO:0051963)	2.50739026
81	vocalization behavior (GO:0071625)	2.49861648
82	aggressive behavior (GO:0002118)	2.49771709
83	cerebral cortex neuron differentiation (GO:0021895)	2.49290538
84	mechanoreceptor differentiation (GO:0042490)	2.47200345
85	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.47036534
86	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.47036534
87	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.47036534
88	regulation of neuronal synaptic plasticity (GO:0048168)	2.46908266
89	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.46357491
90	alkaloid metabolic process (GO:0009820)	2.46202998
91	histone H4 deacetylation (GO:0070933)	2.44708296
92	semaphorin-plexin signaling pathway (GO:0071526)	2.44505325
93	membrane depolarization (GO:0051899)	2.42420169
94	diaphragm development (GO:0060539)	2.40659872
95	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.40465345
96	endocardial cushion morphogenesis (GO:0003203)	2.40243452
97	axoneme assembly (GO:0035082)	2.40168110
98	response to auditory stimulus (GO:0010996)	2.39294388
99	purine nucleoside bisphosphate metabolic process (GO:0034032)	2.39017244
100	ribonucleoside bisphosphate metabolic process (GO:0033875)	2.39017244

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.60004150
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.33552123
3	DROSHA_22980978_ChIP-Seq_HELA_Human	3.13524461
4	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.83191904
5	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.82836829
6	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.69820643
7	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.61120738
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.52642176
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.46615481
10	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.36808909
11	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.33210367
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.32921829
13	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.31550422
14	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.27255529
15	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.20562797
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.17922704
17	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.15834480
18	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.15834480
19	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.11294343
20	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.09042720
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.08665597
22	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.08494911
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.08051631
24	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.04937133
25	DNAJC2_21179169_ChIP-ChIP_NT2_Human	2.02738246
26	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.02679941
27	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.95380447
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.92708421
29	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.92470959
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.87127302
31	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.86845718
32	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.84335441
33	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.77964877
34	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.77959663
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.76376122
36	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.72066470
37	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.67323801
38	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.65968468
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.64330772
40	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.62221487
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61145789
42	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.60508713
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.60342371
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60246076
45	LXR_22292898_ChIP-Seq_THP-1_Human	1.58670864
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.58321477
47	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.58294388
48	VDR_21846776_ChIP-Seq_THP-1_Human	1.56990659
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.55559579
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54184939
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54184939
52	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.48493858
53	KDM2B_26808549_Chip-Seq_K562_Human	1.48157712
54	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.47602356
55	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.44178236
56	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.42959816
57	KDM2B_26808549_Chip-Seq_DND41_Human	1.39642899
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.39220921
59	P68_20966046_ChIP-Seq_HELA_Human	1.35451183
60	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.33606633
61	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30264697
62	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.29586690
63	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.27727646
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23799849
65	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.23380019
66	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.21607759
67	SMC4_20622854_ChIP-Seq_HELA_Human	1.20563424
68	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.19726544
69	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.15905242
70	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.14111972
71	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.13142784
72	CREB1_26743006_Chip-Seq_LNCaP_Human	1.10905077
73	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.10839544
74	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.10380467
75	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.10169259
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08632803
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07710383
78	SA1_22415368_ChIP-Seq_MEFs_Mouse	1.07400055
79	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.04592222
80	SOX3_22085726_ChIP-Seq_NPCs_Mouse	1.03247766
81	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.01032640
82	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99259831
83	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.96093455
84	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.94708057
85	AR_19668381_ChIP-Seq_PC3_Human	0.94071067
86	SOX9_26525672_Chip-Seq_HEART_Mouse	0.93980444
87	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.93861731
88	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.93511075
89	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.93197772
90	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93044653
91	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.92485371
92	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.91080478
93	KLF4_19829295_ChIP-Seq_ESCs_Human	0.87658936
94	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.86498187
95	OCT4_19829295_ChIP-Seq_ESCs_Human	0.85364374
96	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.84892364
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.83314356
98	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.82852451
99	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.81966705
100	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.81915292

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	5.03214860
2	MP0004859_abnormal_synaptic_plasticity	4.51697662
3	MP0003122_maternal_imprinting	4.45651776
4	MP0009384_cardiac_valve_regurgitation	3.60572051
5	MP0005171_absent_coat_pigmentation	3.18544088
6	MP0002009_preneoplasia	3.00974467
7	MP0001188_hyperpigmentation	2.45765787
8	MP0005423_abnormal_somatic_nervous	2.24152760
9	MP0005409_darkened_coat_color	2.20290458
10	MP0000751_myopathy	2.13963448
11	MP0003787_abnormal_imprinting	2.05044607
12	MP0000537_abnormal_urethra_morphology	2.01729711
13	MP0005076_abnormal_cell_differentiation	1.97541982
14	MP0000778_abnormal_nervous_system	1.92406188
15	MP0003635_abnormal_synaptic_transmissio	1.83065593
16	MP0002063_abnormal_learning/memory/cond	1.80256404
17	MP0005083_abnormal_biliary_tract	1.74305278
18	MP0001299_abnormal_eye_distance/	1.73728986
19	MP0006276_abnormal_autonomic_nervous	1.72614818
20	MP0001958_emphysema	1.64991828
21	MP0004885_abnormal_endolymph	1.58722355
22	MP0008569_lethality_at_weaning	1.57610967
23	MP0002064_seizures	1.56329705
24	MP0002638_abnormal_pupillary_reflex	1.51769426
25	MP0004130_abnormal_muscle_cell	1.48802462
26	MP0001502_abnormal_circadian_rhythm	1.46681573
27	MP0003942_abnormal_urinary_system	1.45839029
28	MP0001486_abnormal_startle_reflex	1.42671516
29	MP0000026_abnormal_inner_ear	1.41837723
30	MP0008260_abnormal_autophagy	1.39223992
31	MP0003567_abnormal_fetal_cardiomyocyte	1.38515277
32	MP0002572_abnormal_emotion/affect_behav	1.37199346
33	MP0002282_abnormal_trachea_morphology	1.30992940
34	MP0001963_abnormal_hearing_physiology	1.26515652
35	MP0003121_genomic_imprinting	1.23897552
36	MP0000049_abnormal_middle_ear	1.22446924
37	MP0002249_abnormal_larynx_morphology	1.21407246
38	MP0008875_abnormal_xenobiotic_pharmacok	1.16089434
39	MP0002152_abnormal_brain_morphology	1.14954247
40	MP0000747_muscle_weakness	1.14936181
41	MP0003385_abnormal_body_wall	1.10544089
42	MP0003091_abnormal_cell_migration	1.08597109
43	MP0009840_abnormal_foam_cell	1.07829704
44	MP0003937_abnormal_limbs/digits/tail_de	1.07491724
45	MP0005248_abnormal_Harderian_gland	1.05905598
46	MP0002557_abnormal_social/conspecific_i	1.03387252
47	MP0003329_amyloid_beta_deposits	1.02193397
48	MP0009250_abnormal_appendicular_skeleto	1.01242090
49	MP0005174_abnormal_tail_pigmentation	1.01025557
50	MP0003045_fibrosis	1.00911997
51	MP0000631_abnormal_neuroendocrine_gland	1.00607703
52	MP0002752_abnormal_somatic_nervous	1.00567656
53	MP0002938_white_spotting	1.00206752
54	MP0004270_analgesia	0.99965149
55	MP0008770_decreased_survivor_rate	0.99197681
56	MP0004087_abnormal_muscle_fiber	0.99057483
57	MP0000534_abnormal_ureter_morphology	0.99017756
58	MP0003861_abnormal_nervous_system	0.98518409
59	MP0004145_abnormal_muscle_electrophysio	0.97065210
60	MP0001177_atelectasis	0.93183113
61	MP0003878_abnormal_ear_physiology	0.93156961
62	MP0005377_hearing/vestibular/ear_phenot	0.93156961
63	MP0002882_abnormal_neuron_morphology	0.93086193
64	MP0000579_abnormal_nail_morphology	0.92121368
65	MP0002106_abnormal_muscle_physiology	0.91654059
66	MP0002184_abnormal_innervation	0.90788726
67	MP0003137_abnormal_impulse_conducting	0.90506738
68	MP0002066_abnormal_motor_capabilities/c	0.90330224
69	MP0009745_abnormal_behavioral_response	0.89457934
70	MP0005499_abnormal_olfactory_system	0.88484868
71	MP0005394_taste/olfaction_phenotype	0.88484868
72	MP0003938_abnormal_ear_development	0.88061095
73	MP0002067_abnormal_sensory_capabilities	0.87338896
74	MP0002081_perinatal_lethality	0.85414671
75	MP0002090_abnormal_vision	0.81519497
76	MP0010769_abnormal_survival	0.81103302
77	MP0000955_abnormal_spinal_cord	0.81064233
78	MP0008877_abnormal_DNA_methylation	0.80967765
79	MP0000759_abnormal_skeletal_muscle	0.79450405
80	MP0002082_postnatal_lethality	0.78951076
81	MP0010770_preweaning_lethality	0.78951076
82	MP0000750_abnormal_muscle_regeneration	0.77330110
83	MP0004811_abnormal_neuron_physiology	0.76813950
84	MP0003705_abnormal_hypodermis_morpholog	0.76109487
85	MP0002114_abnormal_axial_skeleton	0.75886187
86	MP0010768_mortality/aging	0.75219693
87	MP0002736_abnormal_nociception_after	0.75101977
88	MP0005620_abnormal_muscle_contractility	0.73788786
89	MP0003890_abnormal_embryonic-extraembry	0.72330236
90	MP0001293_anophthalmia	0.72327577
91	MP0002111_abnormal_tail_morphology	0.71822035
92	MP0004742_abnormal_vestibular_system	0.71686418
93	MP0003634_abnormal_glial_cell	0.71031749
94	MP0003755_abnormal_palate_morphology	0.69408603
95	MP0001440_abnormal_grooming_behavior	0.67129789
96	MP0005330_cardiomyopathy	0.66323210
97	MP0005666_abnormal_adipose_tissue	0.64169741
98	MP0005369_muscle_phenotype	0.63540978
99	MP0001943_abnormal_respiration	0.63511780
100	MP0002896_abnormal_bone_mineralization	0.63198971

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.04631271
2	Myokymia (HP:0002411)	4.83100391
3	Action tremor (HP:0002345)	3.75954759
4	Lipid accumulation in hepatocytes (HP:0006561)	3.71533127
5	Flared iliac wings (HP:0002869)	3.63376888
6	Myotonia (HP:0002486)	3.42991015
7	Achilles tendon contracture (HP:0001771)	3.35622374
8	Abnormality of the lower motor neuron (HP:0002366)	3.26124074
9	Fetal akinesia sequence (HP:0001989)	3.24838158
10	Increased hepatocellular lipid droplets (HP:0006565)	3.22167287
11	Mesangial abnormality (HP:0001966)	3.21540518
12	Turricephaly (HP:0000262)	3.21052408
13	Abnormality of the Achilles tendon (HP:0005109)	3.11392920
14	Coronal craniosynostosis (HP:0004440)	3.10131497
15	Thin ribs (HP:0000883)	3.07731160
16	Rectal prolapse (HP:0002035)	3.06459700
17	Ulnar bowing (HP:0003031)	2.93100659
18	Broad ribs (HP:0000885)	2.91778630
19	Renal Fanconi syndrome (HP:0001994)	2.89395079
20	Ankle clonus (HP:0011448)	2.83375218
21	Lower limb amyotrophy (HP:0007210)	2.81295485
22	Facial hemangioma (HP:0000329)	2.71010834
23	Metaphyseal cupping (HP:0003021)	2.68686279
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65854362
25	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.58364099
26	Ovoid vertebral bodies (HP:0003300)	2.58297852
27	Dyschromatopsia (HP:0007641)	2.58219932
28	Rib fusion (HP:0000902)	2.57689893
29	Sparse lateral eyebrow (HP:0005338)	2.57529119
30	Epiphyseal dysplasia (HP:0002656)	2.56308803
31	Increased muscle lipid content (HP:0009058)	2.54485498
32	Akinesia (HP:0002304)	2.48455573
33	Disproportionate short-trunk short stature (HP:0003521)	2.46018409
34	Poor suck (HP:0002033)	2.45945084
35	Hemorrhage of the eye (HP:0011885)	2.44664669
36	Cervical subluxation (HP:0003308)	2.40287837
37	Joint stiffness (HP:0001387)	2.37091024
38	Choroideremia (HP:0001139)	2.31255737
39	Joint hemorrhage (HP:0005261)	2.28928484
40	Progressive cerebellar ataxia (HP:0002073)	2.26683521
41	Mildly elevated creatine phosphokinase (HP:0008180)	2.25093273
42	Aplasia involving bones of the extremities (HP:0009825)	2.24304752
43	Aplasia involving bones of the upper limbs (HP:0009823)	2.24304752
44	Aplasia of the phalanges of the hand (HP:0009802)	2.24304752
45	Occipital encephalocele (HP:0002085)	2.20738421
46	Increased intramyocellular lipid droplets (HP:0012240)	2.15355469
47	Increased number of teeth (HP:0011069)	2.15222384
48	Retinal dysplasia (HP:0007973)	2.13185156
49	EMG: neuropathic changes (HP:0003445)	2.13009174
50	Testicular atrophy (HP:0000029)	2.11144111
51	Urinary glycosaminoglycan excretion (HP:0003541)	2.09197661
52	Mucopolysacchariduria (HP:0008155)	2.09197661
53	Hypoalphalipoproteinemia (HP:0003233)	2.04628113
54	Abnormal ciliary motility (HP:0012262)	2.03919057
55	Dysdiadochokinesis (HP:0002075)	2.02856821
56	Ulnar deviation of the wrist (HP:0003049)	2.01866657
57	Abnormal urine phosphate concentration (HP:0012599)	2.01715117
58	Abnormality of the corticospinal tract (HP:0002492)	2.00193286
59	Reticulocytosis (HP:0001923)	1.97033404
60	True hermaphroditism (HP:0010459)	1.96630581
61	Spastic gait (HP:0002064)	1.95826632
62	Distal lower limb amyotrophy (HP:0008944)	1.95529876
63	Exertional dyspnea (HP:0002875)	1.94868751
64	Cholelithiasis (HP:0001081)	1.94742385
65	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.94486531
66	Absent epiphyses (HP:0010577)	1.94486531
67	Hypoplasia of the odontoid process (HP:0003311)	1.93295272
68	Male infertility (HP:0003251)	1.90738157
69	Trigonocephaly (HP:0000243)	1.90731693
70	Focal seizures (HP:0007359)	1.89583091
71	Hypoplastic ischia (HP:0003175)	1.88087213
72	Rapidly progressive (HP:0003678)	1.87052298
73	Spina bifida occulta (HP:0003298)	1.86729388
74	Abnormality of the odontoid process (HP:0003310)	1.85857758
75	Brushfield spots (HP:0001088)	1.85845717
76	Abnormality of the ischium (HP:0003174)	1.85040729
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84011836
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.84011836
79	Megalencephaly (HP:0001355)	1.82832070
80	Abnormality of the wing of the ilium (HP:0011867)	1.82656798
81	Midline defect of the nose (HP:0004122)	1.82110474
82	Hypoplastic iliac wings (HP:0002866)	1.82070538
83	Bulbous nose (HP:0000414)	1.81756560
84	Chronic hepatic failure (HP:0100626)	1.80944731
85	Abnormality of renal resorption (HP:0011038)	1.80803140
86	Annular pancreas (HP:0001734)	1.80056905
87	Meningocele (HP:0002435)	1.79354913
88	Hepatocellular necrosis (HP:0001404)	1.77625252
89	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.74843996
90	Abnormality of polysaccharide metabolism (HP:0011012)	1.74843996
91	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.74843996
92	Urethral obstruction (HP:0000796)	1.73697885
93	Mask-like facies (HP:0000298)	1.73149548
94	Prolonged partial thromboplastin time (HP:0003645)	1.72624684
95	High anterior hairline (HP:0009890)	1.70100402
96	Hypoventilation (HP:0002791)	1.69994437
97	Impulsivity (HP:0100710)	1.68026623
98	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.66926899
99	Hypoparathyroidism (HP:0000829)	1.66115041
100	Abnormality of the calcaneus (HP:0008364)	1.65916362

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TYRO3	4.35220301
2	MAPK15	4.33991246
3	NTRK2	3.84246068
4	MARK1	3.50613117
5	NTRK3	3.39187047
6	MAP3K12	2.97003573
7	SIK1	2.86540549
8	PRKD3	2.75354360
9	EPHB2	2.73543268
10	NTRK1	2.41527808
11	MINK1	2.36667030
12	MAPKAPK3	2.33675102
13	TLK1	2.13686231
14	WNK3	1.94029019
15	ICK	1.85153164
16	MAP2K4	1.81378919
17	ERBB3	1.70742161
18	TRIB3	1.67226768
19	FGFR2	1.66910374
20	CDK9	1.59100221
21	SIK2	1.52329420
22	MAP3K11	1.41908924
23	SIK3	1.32338912
24	LATS1	1.30294616
25	MUSK	1.17099363
26	MARK2	1.14011164
27	BMX	1.07960040
28	DDR2	1.06227792
29	LATS2	1.01836152
30	MKNK1	1.01832998
31	PDGFRA	1.00097426
32	PHKG1	0.99225582
33	PHKG2	0.99225582
34	DYRK2	0.98468197
35	RET	0.98222707
36	STK38	0.95266290
37	FGFR4	0.93045412
38	PIK3CA	0.87998566
39	DYRK1B	0.82363470
40	CDK15	0.81495896
41	CDK18	0.81081431
42	MAP2K6	0.80472503
43	CASK	0.78844021
44	EEF2K	0.78589295
45	BCR	0.77925538
46	ERBB2	0.77418278
47	BMPR2	0.76645306
48	TNK2	0.76459632
49	CDK11A	0.76029126
50	FGFR3	0.74361446
51	TTN	0.73164248
52	TNIK	0.70407067
53	WEE1	0.69665028
54	PNCK	0.68102512
55	NEK2	0.67729051
56	PAK3	0.67009376
57	WNK1	0.65560234
58	PRKD1	0.65543405
59	CDK14	0.63661150
60	PRKAA1	0.60796968
61	UHMK1	0.60680292
62	MAPK13	0.58745257
63	CDK5	0.54784609
64	PRKG2	0.54717892
65	MTOR	0.52206677
66	MAP3K7	0.51984792
67	DYRK1A	0.48428081
68	MAP3K10	0.47797735
69	CDK3	0.47329968
70	EPHA3	0.46318254
71	KSR1	0.45818681
72	SGK494	0.45320068
73	SGK223	0.45320068
74	CAMK2A	0.45286264
75	CHEK2	0.44554268
76	MAP2K2	0.44333463
77	OBSCN	0.42824801
78	DAPK1	0.42221196
79	MKNK2	0.40686526
80	MAPK8	0.39747107
81	RPS6KA1	0.39505933
82	CAMK2B	0.38653483
83	EPHA2	0.36254016
84	GSK3B	0.34701255
85	SRC	0.34120848
86	PDPK1	0.34054939
87	MAPK3	0.32590371
88	PRKCG	0.32343079
89	NEK9	0.31738404
90	PKN1	0.31237304
91	RPS6KB1	0.30818359
92	MAP3K1	0.30380396
93	BRSK1	0.29981213
94	KSR2	0.29705049
95	MAP2K3	0.29515727
96	PRKG1	0.29365658
97	MAP3K2	0.29317783
98	FYN	0.28669898
99	PTK6	0.27667306
100	MAPKAPK5	0.27573676

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.79417315
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.69313458
3	Protein export_Homo sapiens_hsa03060	2.44020462
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.38812307
5	Cocaine addiction_Homo sapiens_hsa05030	2.35166941
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.32028737
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.27450970
8	Cholinergic synapse_Homo sapiens_hsa04725	2.04778448
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.89481100
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.88005277
11	Caffeine metabolism_Homo sapiens_hsa00232	1.81929254
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.77506410
13	Long-term potentiation_Homo sapiens_hsa04720	1.74123829
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.69345513
15	Basal cell carcinoma_Homo sapiens_hsa05217	1.65218426
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62133651
17	Amphetamine addiction_Homo sapiens_hsa05031	1.57272428
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56507687
19	Axon guidance_Homo sapiens_hsa04360	1.53754434
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.49337152
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.41764439
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.38921898
23	Dopaminergic synapse_Homo sapiens_hsa04728	1.30101726
24	Hippo signaling pathway_Homo sapiens_hsa04390	1.27185377
25	Taste transduction_Homo sapiens_hsa04742	1.25190097
26	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.23766044
27	Melanogenesis_Homo sapiens_hsa04916	1.20914954
28	Fatty acid elongation_Homo sapiens_hsa00062	1.20686358
29	VEGF signaling pathway_Homo sapiens_hsa04370	1.18486339
30	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.14414181
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12487382
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.11229827
33	Gap junction_Homo sapiens_hsa04540	1.09488306
34	Gastric acid secretion_Homo sapiens_hsa04971	1.08696131
35	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.08148031
36	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.06200324
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.04256198
38	Renin secretion_Homo sapiens_hsa04924	1.04134251
39	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.99951390
40	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.99321358
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.95751239
42	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.95528196
43	Phototransduction_Homo sapiens_hsa04744	0.92100749
44	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.91405279
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.90636785
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89000788
47	Wnt signaling pathway_Homo sapiens_hsa04310	0.88249978
48	Circadian entrainment_Homo sapiens_hsa04713	0.87976340
49	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.87764348
50	Alzheimers disease_Homo sapiens_hsa05010	0.87731359
51	AMPK signaling pathway_Homo sapiens_hsa04152	0.85179093
52	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.83150361
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.79078420
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78932763
55	GABAergic synapse_Homo sapiens_hsa04727	0.77323178
56	mRNA surveillance pathway_Homo sapiens_hsa03015	0.76141131
57	Insulin secretion_Homo sapiens_hsa04911	0.75863885
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71512595
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70000248
60	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.69296935
61	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.68376767
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67362048
63	Morphine addiction_Homo sapiens_hsa05032	0.66448059
64	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.66285900
65	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.64633104
66	Bile secretion_Homo sapiens_hsa04976	0.63729281
67	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.63697242
68	ECM-receptor interaction_Homo sapiens_hsa04512	0.63317183
69	Tight junction_Homo sapiens_hsa04530	0.63190926
70	Salivary secretion_Homo sapiens_hsa04970	0.62392865
71	Serotonergic synapse_Homo sapiens_hsa04726	0.62304812
72	Estrogen signaling pathway_Homo sapiens_hsa04915	0.61687592
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61227513
74	Alcoholism_Homo sapiens_hsa05034	0.58231164
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57776760
76	Parkinsons disease_Homo sapiens_hsa05012	0.57286293
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57273602
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57267036
79	GnRH signaling pathway_Homo sapiens_hsa04912	0.56020232
80	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.55995753
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.55914799
82	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.55260479
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54063037
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.53355215
85	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50943517
86	Huntingtons disease_Homo sapiens_hsa05016	0.49125724
87	Prion diseases_Homo sapiens_hsa05020	0.48524964
88	Endometrial cancer_Homo sapiens_hsa05213	0.46198522
89	Oxidative phosphorylation_Homo sapiens_hsa00190	0.45578330
90	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.44841827
91	Glioma_Homo sapiens_hsa05214	0.44355036
92	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.42572006
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.41941087
94	Renal cell carcinoma_Homo sapiens_hsa05211	0.41383229
95	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39933382
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.39306721
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.36913983
98	Protein digestion and absorption_Homo sapiens_hsa04974	0.36665455
99	Pancreatic secretion_Homo sapiens_hsa04972	0.36151130
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35072090

DUSP8P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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