DUSP8P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.32174729
2positive regulation of gamma-delta T cell activation (GO:0046645)4.44056309
3response to muramyl dipeptide (GO:0032495)4.41783461
4cellular extravasation (GO:0045123)4.32580205
5response to peptidoglycan (GO:0032494)4.19046366
6histone H4 deacetylation (GO:0070933)3.97649642
7NIK/NF-kappaB signaling (GO:0038061)3.76606793
8germinal center formation (GO:0002467)3.67572944
9positive regulation of granulocyte differentiation (GO:0030854)3.63190243
10mannose metabolic process (GO:0006013)3.60032314
11T cell migration (GO:0072678)3.57483917
12histone H3-K36 demethylation (GO:0070544)3.52658963
13regulation of histone H3-K27 methylation (GO:0061085)3.46926818
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40168801
15histone H3 deacetylation (GO:0070932)3.39312051
16regulation of NFAT protein import into nucleus (GO:0051532)3.39059665
17intracellular estrogen receptor signaling pathway (GO:0030520)3.38778835
18positive regulation of B cell differentiation (GO:0045579)3.31803468
19regulation of gamma-delta T cell activation (GO:0046643)3.29037759
20regulation of chemokine biosynthetic process (GO:0045073)3.28690564
21poly(A)+ mRNA export from nucleus (GO:0016973)3.26166503
22histone H3-K4 methylation (GO:0051568)3.22057771
23B cell receptor signaling pathway (GO:0050853)3.20957319
24regulation of granulocyte differentiation (GO:0030852)3.20693659
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16760925
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.15861517
27regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11832408
28positive thymic T cell selection (GO:0045059)3.10576631
29regulation of T-helper 2 cell differentiation (GO:0045628)3.01687170
30negative thymic T cell selection (GO:0045060)3.01566187
31regulation of gamma-delta T cell differentiation (GO:0045586)2.98655490
32histone lysine demethylation (GO:0070076)2.95978250
33regulation of mast cell degranulation (GO:0043304)2.95318945
34histone H3-K4 trimethylation (GO:0080182)2.94820823
35T cell selection (GO:0045058)2.87504950
363-UTR-mediated mRNA stabilization (GO:0070935)2.87234065
37negative regulation of interleukin-12 production (GO:0032695)2.85671341
38Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85201728
39dosage compensation (GO:0007549)2.84396553
40positive T cell selection (GO:0043368)2.84324566
41histone demethylation (GO:0016577)2.83840245
42negative regulation of granulocyte differentiation (GO:0030853)2.79871667
43thymic T cell selection (GO:0045061)2.79021510
44cellular response to thyroid hormone stimulus (GO:0097067)2.78738493
45regulation of chromatin binding (GO:0035561)2.77264895
46regulation of leukocyte degranulation (GO:0043300)2.76994806
47negative regulation of phagocytosis (GO:0050765)2.76751919
48negative regulation of interleukin-8 production (GO:0032717)2.75537216
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74259590
50negative regulation of cell killing (GO:0031342)2.74259590
51positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.74201534
52macrophage activation involved in immune response (GO:0002281)2.74036126
53response to protozoan (GO:0001562)2.73487074
54protein-DNA complex disassembly (GO:0032986)2.72755245
55nucleosome disassembly (GO:0006337)2.72755245
56regulation of ARF GTPase activity (GO:0032312)2.72733462
57mucosal-associated lymphoid tissue development (GO:0048537)2.72644145
58Peyers patch development (GO:0048541)2.72644145
59regulation of vitamin D biosynthetic process (GO:0060556)2.72184015
60immunoglobulin mediated immune response (GO:0016064)2.70456690
61regulation of mast cell activation involved in immune response (GO:0033006)2.70362778
62response to laminar fluid shear stress (GO:0034616)2.70081681
63regulation of B cell receptor signaling pathway (GO:0050855)2.69027099
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69009724
65negative T cell selection (GO:0043383)2.67573380
66megakaryocyte development (GO:0035855)2.64327252
67CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.63717730
68defense response to protozoan (GO:0042832)2.62069797
69V(D)J recombination (GO:0033151)2.61815623
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60509740
71positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60411417
72histone H3-K9 demethylation (GO:0033169)2.59082110
73neutrophil activation involved in immune response (GO:0002283)2.58967035
74positive regulation of myotube differentiation (GO:0010831)2.58786815
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58649488
76cellular response to ethanol (GO:0071361)2.57804780
77negative regulation of gene expression, epigenetic (GO:0045814)2.56991360
78neutrophil mediated immunity (GO:0002446)2.54914439
79protein demethylation (GO:0006482)2.54653721
80protein dealkylation (GO:0008214)2.54653721
81spermatid nucleus differentiation (GO:0007289)2.54537132
82positive regulation by symbiont of host defense response (GO:0052509)2.54079054
83modulation by symbiont of host defense response (GO:0052031)2.54079054
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54079054
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54079054
86positive regulation by organism of defense response of other organism involved in symbiotic interact2.54079054
87modulation by symbiont of host immune response (GO:0052553)2.54079054
88positive regulation of chemokine biosynthetic process (GO:0045080)2.54026644
89B cell homeostasis (GO:0001782)2.52511017
90regulation of interleukin-2 biosynthetic process (GO:0045076)2.51462587
91regulation of erythrocyte differentiation (GO:0045646)2.51154046
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.48972413
93myeloid cell activation involved in immune response (GO:0002275)2.47793385
94regulation of monocyte differentiation (GO:0045655)2.46647015
95histone deacetylation (GO:0016575)2.46309613
96natural killer cell differentiation (GO:0001779)2.43966023
97negative regulation of growth of symbiont in host (GO:0044130)2.42510673
98negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.42510673
99modulation of growth of symbiont involved in interaction with host (GO:0044144)2.42510673
100regulation of growth of symbiont in host (GO:0044126)2.42510673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.92558105
2MYC_22102868_ChIP-Seq_BL_Human3.68885176
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.97697100
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.73906314
5KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.71299080
6VDR_24763502_ChIP-Seq_THP-1_Human2.57285803
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53383613
8KDM2B_26808549_Chip-Seq_DND41_Human2.52972203
9LXR_22292898_ChIP-Seq_THP-1_Human2.50709203
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47411865
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44354767
12TCF7_22412390_ChIP-Seq_EML_Mouse2.40986774
13MAF_26560356_Chip-Seq_TH1_Human2.38159695
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27533224
15MAF_26560356_Chip-Seq_TH2_Human2.24000878
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22979209
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22039007
18UTX_26944678_Chip-Seq_JUKART_Human2.21173741
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.19449375
20CIITA_25753668_ChIP-Seq_RAJI_Human2.16312077
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08782115
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00519536
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98804989
24SCL_19346495_ChIP-Seq_HPC-7_Human1.95429929
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.94969660
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.93108270
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91817157
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91512844
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83495035
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82443166
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79023556
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75773042
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.72093172
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.70293448
35NCOR1_26117541_ChIP-Seq_K562_Human1.70071697
36P68_20966046_ChIP-Seq_HELA_Human1.69954615
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66266879
38MYB_26560356_Chip-Seq_TH2_Human1.64756291
39SPI1_23547873_ChIP-Seq_NB4_Human1.61283085
40SPI1_23127762_ChIP-Seq_K562_Human1.60390809
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59640291
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58106588
43BCL6_27268052_Chip-Seq_Bcells_Human1.57432086
44MYB_26560356_Chip-Seq_TH1_Human1.56543442
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56345797
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55600489
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.55514996
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50370001
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48593749
50BCOR_27268052_Chip-Seq_Bcells_Human1.48364855
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47027773
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.46104821
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40735787
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37276560
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36880854
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36527629
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36523004
58KDM2B_26808549_Chip-Seq_K562_Human1.35878961
59GATA1_19941826_ChIP-Seq_K562_Human1.34850331
60RUNX_20019798_ChIP-Seq_JUKART_Human1.34319409
61RACK7_27058665_Chip-Seq_MCF-7_Human1.34015948
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.33813468
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33194763
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33083603
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30967269
66SMC4_20622854_ChIP-Seq_HELA_Human1.30270423
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.29048608
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28211599
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27046403
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25982683
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25975247
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23670964
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22659892
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.21369222
75PHF8_20622854_ChIP-Seq_HELA_Human1.19190068
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18831240
77CTCF_21964334_Chip-Seq_Bcells_Human1.18455223
78TFEB_21752829_ChIP-Seq_HELA_Human1.16903605
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14392922
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13990744
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13542860
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11587877
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10953747
84CREB1_26743006_Chip-Seq_LNCaP_Human1.10888898
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10427555
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09100154
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08125232
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07805441
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07734062
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07507866
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06819844
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05712022
93E2F1_20622854_ChIP-Seq_HELA_Human1.05691690
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.03169047
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02786639
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99559849
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99440737
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98687948
99GATA3_27048872_Chip-Seq_THYMUS_Human0.97337063
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96275615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.76930200
2MP0003436_decreased_susceptibility_to3.76532551
3MP0005451_abnormal_body_composition3.65519480
4MP0003303_peritoneal_inflammation3.39939514
5MP0003172_abnormal_lysosome_physiology3.38026855
6MP0005058_abnormal_lysosome_morphology3.04933670
7MP0005397_hematopoietic_system_phenotyp2.93425934
8MP0001545_abnormal_hematopoietic_system2.93425934
9MP0001835_abnormal_antigen_presentation2.52823333
10MP0005000_abnormal_immune_tolerance2.33465555
11MP0003763_abnormal_thymus_physiology2.32427085
12MP0002419_abnormal_innate_immunity2.31011466
13MP0001800_abnormal_humoral_immune2.30167301
14MP0005387_immune_system_phenotype2.19206789
15MP0001790_abnormal_immune_system2.19206789
16MP0005671_abnormal_response_to2.15747431
17MP0005025_abnormal_response_to2.14380615
18MP0002723_abnormal_immune_serum2.04437953
19MP0002452_abnormal_antigen_presenting2.00140272
20MP0002420_abnormal_adaptive_immunity1.99275988
21MP0001819_abnormal_immune_cell1.96931353
22MP0002398_abnormal_bone_marrow1.95038278
23MP0003656_abnormal_erythrocyte_physiolo1.93927556
24MP0009785_altered_susceptibility_to1.92199569
25MP0004947_skin_inflammation1.91426282
26MP0000685_abnormal_immune_system1.90076572
27MP0003300_gastrointestinal_ulcer1.88010510
28MP0009333_abnormal_splenocyte_physiolog1.83923708
29MP0001853_heart_inflammation1.83580139
30MP0004510_myositis1.80635802
31MP0001873_stomach_inflammation1.73446899
32MP0005410_abnormal_fertilization1.71931514
33MP0000716_abnormal_immune_system1.70859882
34MP0009840_abnormal_foam_cell1.68539663
35MP0002722_abnormal_immune_system1.68501947
36MP0002405_respiratory_system_inflammati1.64627315
37MP0003221_abnormal_cardiomyocyte_apopto1.61602556
38MP0000703_abnormal_thymus_morphology1.57867120
39MP0005076_abnormal_cell_differentiation1.56470714
40MP0000689_abnormal_spleen_morphology1.56063749
41MP0005464_abnormal_platelet_physiology1.53590442
42MP0002148_abnormal_hypersensitivity_rea1.52679681
43MP0002396_abnormal_hematopoietic_system1.52450042
44MP0003091_abnormal_cell_migration1.47588645
45MP0002429_abnormal_blood_cell1.47565801
46MP0006082_CNS_inflammation1.44364206
47MP0002132_abnormal_respiratory_system1.39502068
48MP0004808_abnormal_hematopoietic_stem1.39201644
49MP0008995_early_reproductive_senescence1.37728346
50MP0001533_abnormal_skeleton_physiology1.32120865
51MP0010155_abnormal_intestine_physiology1.29700581
52MP0005666_abnormal_adipose_tissue1.29094195
53MP0001845_abnormal_inflammatory_respons1.22302310
54MP0002998_abnormal_bone_remodeling1.20768925
55MP0003191_abnormal_cellular_cholesterol1.19394112
56MP0008260_abnormal_autophagy1.19035336
57MP0004185_abnormal_adipocyte_glucose1.17238872
58MP0000858_altered_metastatic_potential1.16374023
59MP0008057_abnormal_DNA_replication1.13837720
60MP0002933_joint_inflammation1.11350851
61MP0008469_abnormal_protein_level1.09876220
62MP0002877_abnormal_melanocyte_morpholog1.07909049
63MP0004233_abnormal_muscle_weight1.06525029
64MP0005375_adipose_tissue_phenotype1.06481000
65MP0003724_increased_susceptibility_to1.03287828
66MP0002166_altered_tumor_susceptibility1.01445952
67MP0005645_abnormal_hypothalamus_physiol1.01230737
68MP0001849_ear_inflammation1.00263327
69MP0000465_gastrointestinal_hemorrhage0.99041126
70MP0009764_decreased_sensitivity_to0.94773267
71MP0000733_abnormal_muscle_development0.90194578
72MP0000490_abnormal_crypts_of0.90143883
73MP0005310_abnormal_salivary_gland0.87656270
74MP0002009_preneoplasia0.87576822
75MP0001348_abnormal_lacrimal_gland0.86864091
76MP0001986_abnormal_taste_sensitivity0.84816464
77MP0000343_altered_response_to0.82985482
78MP0002019_abnormal_tumor_incidence0.82877314
79MP0009384_cardiac_valve_regurgitation0.81275451
80MP0000681_abnormal_thyroid_gland0.80824676
81MP0000604_amyloidosis0.80229126
82MP0000003_abnormal_adipose_tissue0.79280015
83MP0008961_abnormal_basal_metabolism0.77970382
84MP0003828_pulmonary_edema0.75826348
85MP0005621_abnormal_cell_physiology0.75431722
86MP0009115_abnormal_fat_cell0.74837202
87MP0008874_decreased_physiological_sensi0.72890276
88MP0003453_abnormal_keratinocyte_physiol0.71011266
89MP0002332_abnormal_exercise_endurance0.68558668
90MP0000313_abnormal_cell_death0.66547788
91MP0000751_myopathy0.65856092
92MP0003279_aneurysm0.65818174
93MP0001851_eye_inflammation0.65455652
94MP0000759_abnormal_skeletal_muscle0.65086028
95MP0000249_abnormal_blood_vessel0.65068336
96MP0002970_abnormal_white_adipose0.64940370
97MP0000678_abnormal_parathyroid_gland0.64103588
98MP0009931_abnormal_skin_appearance0.60264611
99MP0005334_abnormal_fat_pad0.60134492
100MP0003795_abnormal_bone_structure0.60080598

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)3.98244921
2B lymphocytopenia (HP:0010976)3.67709928
3Dysostosis multiplex (HP:0000943)3.61496466
4Abnormality of B cell number (HP:0010975)3.41806507
5Granulocytopenia (HP:0001913)3.34865146
6Severe combined immunodeficiency (HP:0004430)3.28427208
7Abnormality of polysaccharide metabolism (HP:0011012)3.20455966
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20455966
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20455966
10Hypoplasia of the thymus (HP:0000778)3.13645046
11Mucopolysacchariduria (HP:0008155)3.08534459
12Urinary glycosaminoglycan excretion (HP:0003541)3.08534459
13Abnormality of the fingertips (HP:0001211)3.06322602
14Abnormality of liposaccharide metabolism (HP:0010968)3.05583471
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.05583471
16Abnormality of glycolipid metabolism (HP:0010969)3.05583471
17Agammaglobulinemia (HP:0004432)3.01651345
18Asymmetric septal hypertrophy (HP:0001670)3.01250263
19Combined immunodeficiency (HP:0005387)2.96281651
20Cellulitis (HP:0100658)2.93791376
21Recurrent viral infections (HP:0004429)2.92479208
22Obstructive lung disease (HP:0006536)2.90152961
23Chronic obstructive pulmonary disease (HP:0006510)2.90152961
24Reticulocytosis (HP:0001923)2.89448412
25Loss of speech (HP:0002371)2.88188809
26Thrombocytosis (HP:0001894)2.86255192
27Meningitis (HP:0001287)2.82641819
28Elevated erythrocyte sedimentation rate (HP:0003565)2.79151549
29Colitis (HP:0002583)2.78560716
30Hemorrhage of the eye (HP:0011885)2.74720930
31Hypertensive crisis (HP:0100735)2.74519533
32Broad face (HP:0000283)2.68106773
33Increased serum ferritin (HP:0003281)2.64981079
34Distal lower limb amyotrophy (HP:0008944)2.61962188
35Chest pain (HP:0100749)2.58677840
36Ragged-red muscle fibers (HP:0003200)2.58397904
37Recurrent fungal infections (HP:0002841)2.57249826
38Eosinophilia (HP:0001880)2.56529001
39Eczematoid dermatitis (HP:0000976)2.52483782
40Vacuolated lymphocytes (HP:0001922)2.43250305
41Fatigue (HP:0012378)2.41821105
42Mediastinal lymphadenopathy (HP:0100721)2.38726552
43Abnormality of macrophages (HP:0004311)2.37112169
44Gastrointestinal inflammation (HP:0004386)2.37050753
45Abnormality of eosinophils (HP:0001879)2.35571358
46Tubulointerstitial nephritis (HP:0001970)2.33895203
47Aplasia/Hypoplasia of the thymus (HP:0010515)2.25677998
48Slow saccadic eye movements (HP:0000514)2.24142322
49Leukocytosis (HP:0001974)2.23852081
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21140587
51Recurrent bacterial skin infections (HP:0005406)2.15804370
52Polycythemia (HP:0001901)2.14848662
53Recurrent abscess formation (HP:0002722)2.13804072
54Sepsis (HP:0100806)2.13500892
55Inflammation of the large intestine (HP:0002037)2.13483092
56Epistaxis (HP:0000421)2.10893451
57Neuronal loss in central nervous system (HP:0002529)2.08146369
58Abnormality of reticulocytes (HP:0004312)2.07160020
59Abnormality of iron homeostasis (HP:0011031)2.06024296
60T lymphocytopenia (HP:0005403)2.02095507
61Rhabdomyolysis (HP:0003201)2.00096569
62Seborrheic dermatitis (HP:0001051)1.99059123
63Joint stiffness (HP:0001387)1.99012641
64Cervical subluxation (HP:0003308)1.98518453
65Verrucae (HP:0200043)1.97325837
66Papilloma (HP:0012740)1.97325837
67Hepatosplenomegaly (HP:0001433)1.96668647
68Vasculitis (HP:0002633)1.96001653
69Severe visual impairment (HP:0001141)1.95779044
70Exercise-induced myalgia (HP:0003738)1.95606437
71Abnormal gallbladder physiology (HP:0012438)1.95501713
72Cholecystitis (HP:0001082)1.95501713
73Peripheral hypomyelination (HP:0007182)1.92701782
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92452299
75Microvesicular hepatic steatosis (HP:0001414)1.91681757
76Easy fatigability (HP:0003388)1.91653820
77Spontaneous hematomas (HP:0007420)1.91019036
78Petechiae (HP:0000967)1.89320909
79Increased IgE level (HP:0003212)1.88260504
80Gastrointestinal stroma tumor (HP:0100723)1.86821554
81Hypergammaglobulinemia (HP:0010702)1.85769001
82Abnormality of the columella (HP:0009929)1.85729374
83Autoimmune thrombocytopenia (HP:0001973)1.85700161
84Ureteral stenosis (HP:0000071)1.83679729
85Personality changes (HP:0000751)1.83522028
86Increased cerebral lipofuscin (HP:0011813)1.83159729
87Myositis (HP:0100614)1.81172863
88Obstructive sleep apnea (HP:0002870)1.79910939
89Abnormality of transition element cation homeostasis (HP:0011030)1.79595774
90Ureteral obstruction (HP:0006000)1.79303083
91Acrocyanosis (HP:0001063)1.78485944
92Interstitial pulmonary disease (HP:0006530)1.78356700
93Abnormality of lateral ventricle (HP:0030047)1.78005162
94Restrictive lung disease (HP:0002091)1.77800435
95J-shaped sella turcica (HP:0002680)1.76756156
96Myopathic facies (HP:0002058)1.75798442
97Abnormality of the prostate (HP:0008775)1.75784292
98Thin bony cortex (HP:0002753)1.74332532
99Prolonged bleeding time (HP:0003010)1.71899666
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.71204576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.29742556
2ERN13.15521077
3MAP4K13.14149344
4CDK122.78043193
5RIPK42.67795204
6MAP2K32.58508469
7TRIB32.56777412
8IRAK32.38358805
9SIK32.21686866
10SIK22.09051009
11EEF2K2.08860710
12MAP3K141.95490031
13ICK1.94877607
14MAP3K101.77124426
15BRD41.68039991
16PIK3CG1.67662056
17MAP3K131.67178246
18EPHB11.61457098
19SIK11.60814806
20TBK11.52547197
21IRAK41.51843164
22MATK1.49403077
23MAP3K61.46780888
24TYK21.38332081
25MAP3K111.37839843
26TAOK21.34034658
27SCYL21.32127289
28BLK1.29209143
29EPHA31.27340057
30BTK1.26382300
31MARK21.24614187
32MAP4K21.23834490
33ZAP701.18665870
34TAOK11.17307146
35TNK21.15341893
36NME21.09797001
37DDR21.09637852
38TESK21.08537002
39TESK11.08372426
40CDK41.08341896
41DYRK1B1.07621935
42PKN21.06424090
43JAK31.05114252
44MAP3K71.04358467
45IKBKB0.98643027
46CDC42BPA0.97931843
47SYK0.97599170
48FES0.88332384
49TTN0.88064935
50PDK10.85529503
51KIT0.83732920
52HCK0.83730411
53PDPK10.83627689
54BMPR20.82783310
55MTOR0.82516041
56SMG10.81941316
57CLK10.81764922
58MAP3K10.79272381
59PIM20.79076807
60GRK60.76248848
61PRKD20.75818867
62MAPK110.74639419
63BCKDK0.74507304
64MAP2K40.73978813
65CSF1R0.73701357
66TRIM280.72588315
67MAPK120.72375581
68RPS6KC10.70716282
69RPS6KL10.70716282
70MAPK150.70093401
71CDK60.68848728
72ITK0.68242622
73CAMK1D0.67646167
74HIPK20.66637342
75CHUK0.66421844
76RPS6KA20.65778461
77LYN0.65544330
78IKBKE0.62056096
79IRAK20.61290939
80JAK10.61132270
81LCK0.60872477
82FGFR40.60219859
83MAP3K30.59673133
84KSR20.59003291
85MAP2K70.58559773
86JAK20.58378969
87MAP3K50.57525607
88TXK0.57253274
89CSK0.55611132
90TEC0.54349661
91RET0.54191714
92PDGFRA0.53366633
93RPS6KA60.50735624
94MAPK70.50275425
95CDK90.48286588
96CAMK40.47135315
97MOS0.46934143
98NEK90.44659666
99FLT30.43376545
100DYRK30.41728771

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.53113852
2Acute myeloid leukemia_Homo sapiens_hsa052212.50733296
3B cell receptor signaling pathway_Homo sapiens_hsa046622.38560490
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.13287848
5Primary immunodeficiency_Homo sapiens_hsa053402.08301395
6Osteoclast differentiation_Homo sapiens_hsa043802.01828001
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00651852
8Leishmaniasis_Homo sapiens_hsa051401.83226754
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82278995
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80136535
11Allograft rejection_Homo sapiens_hsa053301.69949242
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67667396
13Influenza A_Homo sapiens_hsa051641.66776589
14Toxoplasmosis_Homo sapiens_hsa051451.59319573
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.58057848
16Hepatitis B_Homo sapiens_hsa051611.54249019
17Chronic myeloid leukemia_Homo sapiens_hsa052201.52861957
18TNF signaling pathway_Homo sapiens_hsa046681.47716692
19T cell receptor signaling pathway_Homo sapiens_hsa046601.46936213
20Herpes simplex infection_Homo sapiens_hsa051681.43675410
21Graft-versus-host disease_Homo sapiens_hsa053321.41247385
22VEGF signaling pathway_Homo sapiens_hsa043701.39227530
23Tuberculosis_Homo sapiens_hsa051521.39027405
24mTOR signaling pathway_Homo sapiens_hsa041501.38254458
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.37879644
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.37740500
27Non-small cell lung cancer_Homo sapiens_hsa052231.37643715
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37065272
29Autoimmune thyroid disease_Homo sapiens_hsa053201.35455892
30Viral myocarditis_Homo sapiens_hsa054161.34193335
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32601520
32Asthma_Homo sapiens_hsa053101.30930827
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30737477
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29938539
35Lysosome_Homo sapiens_hsa041421.28399183
36Measles_Homo sapiens_hsa051621.25939415
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24087770
38Shigellosis_Homo sapiens_hsa051311.22321743
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.21697009
40Prolactin signaling pathway_Homo sapiens_hsa049171.19545821
41Staphylococcus aureus infection_Homo sapiens_hsa051501.14249911
42Notch signaling pathway_Homo sapiens_hsa043301.13122008
43Pancreatic cancer_Homo sapiens_hsa052121.12081408
44Epstein-Barr virus infection_Homo sapiens_hsa051691.11816342
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09258797
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08590377
47Apoptosis_Homo sapiens_hsa042101.05258862
48Hematopoietic cell lineage_Homo sapiens_hsa046401.04594258
49Type II diabetes mellitus_Homo sapiens_hsa049301.03778831
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.01687122
51Type I diabetes mellitus_Homo sapiens_hsa049401.01360019
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00675602
53Pertussis_Homo sapiens_hsa051331.00110351
54Salmonella infection_Homo sapiens_hsa051320.99375438
55Hepatitis C_Homo sapiens_hsa051600.99233076
56Antigen processing and presentation_Homo sapiens_hsa046120.98319874
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97276709
58Renal cell carcinoma_Homo sapiens_hsa052110.96347048
59Malaria_Homo sapiens_hsa051440.95090404
60Colorectal cancer_Homo sapiens_hsa052100.93887601
61Inositol phosphate metabolism_Homo sapiens_hsa005620.93213980
62Legionellosis_Homo sapiens_hsa051340.91649603
63Bladder cancer_Homo sapiens_hsa052190.91648705
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.91184644
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88798021
66Viral carcinogenesis_Homo sapiens_hsa052030.84478687
67HTLV-I infection_Homo sapiens_hsa051660.81701918
68Chemokine signaling pathway_Homo sapiens_hsa040620.79071983
69ErbB signaling pathway_Homo sapiens_hsa040120.78318899
70Endometrial cancer_Homo sapiens_hsa052130.77755409
71FoxO signaling pathway_Homo sapiens_hsa040680.77143635
72Choline metabolism in cancer_Homo sapiens_hsa052310.76824135
73Insulin resistance_Homo sapiens_hsa049310.74785274
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74773923
75HIF-1 signaling pathway_Homo sapiens_hsa040660.74214396
76Endocytosis_Homo sapiens_hsa041440.73833002
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73124689
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.72736461
79Rheumatoid arthritis_Homo sapiens_hsa053230.71294333
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70078821
81Platelet activation_Homo sapiens_hsa046110.68562723
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68078962
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66768338
84Phagosome_Homo sapiens_hsa041450.65434593
85Glioma_Homo sapiens_hsa052140.64820948
86Insulin signaling pathway_Homo sapiens_hsa049100.63885448
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61737479
88Prostate cancer_Homo sapiens_hsa052150.60272478
89GnRH signaling pathway_Homo sapiens_hsa049120.56890612
90mRNA surveillance pathway_Homo sapiens_hsa030150.56463453
91Base excision repair_Homo sapiens_hsa034100.55301137
92Lysine degradation_Homo sapiens_hsa003100.54538032
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54367251
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52449910
95African trypanosomiasis_Homo sapiens_hsa051430.52241851
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49838421
97AMPK signaling pathway_Homo sapiens_hsa041520.49629476
98Amoebiasis_Homo sapiens_hsa051460.48596804
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48361826
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.47678605

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