DUSP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)8.22754323
2plasma lipoprotein particle assembly (GO:0034377)8.20681505
3negative regulation of fibrinolysis (GO:0051918)7.68253655
4protein-lipid complex assembly (GO:0065005)7.30848538
5intestinal cholesterol absorption (GO:0030299)7.23957311
6regulation of gene silencing by RNA (GO:0060966)7.22393555
7regulation of posttranscriptional gene silencing (GO:0060147)7.22393555
8regulation of gene silencing by miRNA (GO:0060964)7.22393555
9low-density lipoprotein particle remodeling (GO:0034374)7.14285208
10peptidyl-glutamic acid carboxylation (GO:0017187)7.08911772
11protein carboxylation (GO:0018214)7.08911772
12regulation of cholesterol esterification (GO:0010872)6.54723561
13plasma lipoprotein particle remodeling (GO:0034369)6.47626093
14protein-lipid complex remodeling (GO:0034368)6.47626093
15macromolecular complex remodeling (GO:0034367)6.47626093
16regulation of fibrinolysis (GO:0051917)6.41582951
17cholesterol efflux (GO:0033344)6.40836123
18plasma lipoprotein particle organization (GO:0071827)6.19960307
19high-density lipoprotein particle remodeling (GO:0034375)5.89312898
20protein-lipid complex subunit organization (GO:0071825)5.83125427
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80722098
22plasma lipoprotein particle clearance (GO:0034381)5.80063779
23regulation of cholesterol homeostasis (GO:2000188)5.76373833
24reverse cholesterol transport (GO:0043691)5.64822933
25regulation of apoptotic cell clearance (GO:2000425)5.48763302
26proline metabolic process (GO:0006560)5.37759394
27regulation of protein activation cascade (GO:2000257)5.31467283
28regulation of complement activation (GO:0030449)5.20652491
29regulation of plasminogen activation (GO:0010755)5.18954021
30regulation of bile acid biosynthetic process (GO:0070857)5.15838926
31nuclear pore organization (GO:0006999)5.11586548
32negative regulation of cholesterol transport (GO:0032375)4.98718075
33negative regulation of sterol transport (GO:0032372)4.98718075
34polarized epithelial cell differentiation (GO:0030859)4.94416234
35establishment of apical/basal cell polarity (GO:0035089)4.92861727
36regulation of cholesterol biosynthetic process (GO:0045540)4.92376414
37DNA unwinding involved in DNA replication (GO:0006268)4.88741707
38nuclear pore complex assembly (GO:0051292)4.87590318
39paraxial mesoderm development (GO:0048339)4.83120884
40proline biosynthetic process (GO:0006561)4.73244374
41intestinal absorption (GO:0050892)4.72435942
42blood coagulation, intrinsic pathway (GO:0007597)4.72137787
43regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.71070277
44regulation of hippo signaling (GO:0035330)4.70700632
45pre-miRNA processing (GO:0031054)4.66098121
46lung epithelium development (GO:0060428)4.65000959
47heterochromatin organization (GO:0070828)4.64787746
48folic acid-containing compound biosynthetic process (GO:0009396)4.50850253
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.48017953
50L-phenylalanine metabolic process (GO:0006558)4.48017953
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.40218961
52L-phenylalanine catabolic process (GO:0006559)4.40218961
53low-density lipoprotein particle clearance (GO:0034383)4.40196315
54phospholipid efflux (GO:0033700)4.38631755
55positive regulation of fatty acid biosynthetic process (GO:0045723)4.35274237
56DNA replication-dependent nucleosome organization (GO:0034723)4.30209147
57DNA replication-dependent nucleosome assembly (GO:0006335)4.30209147
58establishment of monopolar cell polarity (GO:0061162)4.19471707
59establishment or maintenance of monopolar cell polarity (GO:0061339)4.19471707
60histone H4-K12 acetylation (GO:0043983)4.14240927
61DNA replication initiation (GO:0006270)4.13669722
62lipoprotein metabolic process (GO:0042157)4.11987868
63mitotic nuclear envelope disassembly (GO:0007077)4.06964160
64positive regulation of SMAD protein import into nucleus (GO:0060391)4.05371704
65cholesterol homeostasis (GO:0042632)4.03549842
66cellular zinc ion homeostasis (GO:0006882)4.03411804
67sterol transport (GO:0015918)4.02530197
68cholesterol transport (GO:0030301)4.02530197
69diacylglycerol metabolic process (GO:0046339)4.02168766
70histone H2A monoubiquitination (GO:0035518)4.00029682
71sterol homeostasis (GO:0055092)3.99299391
72regulation of translational fidelity (GO:0006450)3.96855234
73protein localization to kinetochore (GO:0034501)3.95601121
74trophectodermal cell differentiation (GO:0001829)3.93387204
75glutamate metabolic process (GO:0006536)3.92937786
76regulation of gene silencing (GO:0060968)3.91293378
77positive regulation of steroid metabolic process (GO:0045940)3.90713202
78mitotic sister chromatid segregation (GO:0000070)3.90056761
79oligosaccharide catabolic process (GO:0009313)3.89442858
80nucleobase biosynthetic process (GO:0046112)3.87182213
81membrane disassembly (GO:0030397)3.83403564
82nuclear envelope disassembly (GO:0051081)3.83403564
83IMP biosynthetic process (GO:0006188)3.80814938
84formation of translation preinitiation complex (GO:0001731)3.80098590
85positive regulation of extracellular matrix organization (GO:1903055)3.75502860
86phosphate ion homeostasis (GO:0055062)3.75009745
87trivalent inorganic anion homeostasis (GO:0072506)3.75009745
88positive regulation of lipoprotein lipase activity (GO:0051006)3.71349133
89positive regulation of triglyceride lipase activity (GO:0061365)3.71349133
90regulation of cholesterol metabolic process (GO:0090181)3.60940301
91regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.58932527
92positive regulation of hormone metabolic process (GO:0032352)3.58864205
93pinocytosis (GO:0006907)3.55556246
94pore complex assembly (GO:0046931)3.55515494
95peptidyl-arginine omega-N-methylation (GO:0035247)3.53913322
96negative regulation of sodium ion transport (GO:0010766)3.53888091
97sister chromatid segregation (GO:0000819)3.53471649
98mitotic metaphase plate congression (GO:0007080)3.52991847
99chromatin assembly (GO:0031497)3.52292777
100embryonic retina morphogenesis in camera-type eye (GO:0060059)3.49632342
101negative regulation of protein activation cascade (GO:2000258)3.47235706
102regulation of SMAD protein import into nucleus (GO:0060390)3.46889942
103positive regulation of hormone biosynthetic process (GO:0046886)3.46780322
104regulation of extracellular matrix organization (GO:1903053)3.46712881
105negative regulation of lipase activity (GO:0060192)3.44106205
106negative regulation of histone methylation (GO:0031061)3.43984645
107acute-phase response (GO:0006953)3.42473301
108DNA duplex unwinding (GO:0032508)3.41922266
109positive regulation of blood coagulation (GO:0030194)3.41717871
110positive regulation of hemostasis (GO:1900048)3.41717871
111histone arginine methylation (GO:0034969)3.41280047
112purine nucleobase biosynthetic process (GO:0009113)3.41221617
113DNA geometric change (GO:0032392)3.40726419
114maturation of SSU-rRNA (GO:0030490)3.40227597
115regulation of histone H3-K9 methylation (GO:0051570)3.39441441
116ribosome assembly (GO:0042255)3.37970197
117triglyceride homeostasis (GO:0070328)3.35783234
118acylglycerol homeostasis (GO:0055090)3.35783234
119DNA strand elongation involved in DNA replication (GO:0006271)3.35135149
120lipid homeostasis (GO:0055088)3.32266310
121fibrinolysis (GO:0042730)3.28815574
122regulation of extracellular matrix disassembly (GO:0010715)3.27142259
123renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.26993187
124dicarboxylic acid biosynthetic process (GO:0043650)3.26558870
125placenta development (GO:0001890)3.26326143
126IMP metabolic process (GO:0046040)3.25852673
127anterior/posterior axis specification, embryo (GO:0008595)3.21461887
128regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.20944778
129modified amino acid transport (GO:0072337)3.20840196
130nodal signaling pathway (GO:0038092)3.20699931
131regulation of helicase activity (GO:0051095)3.19900642
132regulation of telomere maintenance via telomerase (GO:0032210)3.19190576
133somatic hypermutation of immunoglobulin genes (GO:0016446)3.18993042
134somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18993042
135regulation of translational termination (GO:0006449)3.15434850
136DNA strand elongation (GO:0022616)3.14595158
137glutamine family amino acid biosynthetic process (GO:0009084)3.14481766
138complement activation, alternative pathway (GO:0006957)3.13827175
139protein localization to chromosome, centromeric region (GO:0071459)3.12952310
140DNA replication checkpoint (GO:0000076)3.12737614
141positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.11871736
142negative regulation of hemostasis (GO:1900047)3.10678302
143negative regulation of blood coagulation (GO:0030195)3.10678302
144negative regulation of gene silencing (GO:0060969)3.10148707
145protein K6-linked ubiquitination (GO:0085020)3.08652243
146positive regulation of coagulation (GO:0050820)3.07093544
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06837980
148regulation of fatty acid biosynthetic process (GO:0042304)3.06723390
149positive regulation of chromosome segregation (GO:0051984)3.05628425
150neutral lipid catabolic process (GO:0046461)3.05316197
151acylglycerol catabolic process (GO:0046464)3.05316197
152basement membrane organization (GO:0071711)3.04323717
153ribosome biogenesis (GO:0042254)3.02916832
154metaphase plate congression (GO:0051310)3.01688953
155peptidyl-arginine methylation (GO:0018216)3.00592555
156peptidyl-arginine N-methylation (GO:0035246)3.00592555
157peptidyl-glutamic acid modification (GO:0018200)2.99523280
158nephron epithelium morphogenesis (GO:0072088)2.97379130
159nephron tubule morphogenesis (GO:0072078)2.97379130
160chaperone-mediated protein complex assembly (GO:0051131)2.95841531
161regulation of spindle organization (GO:0090224)2.94394309
162spliceosomal tri-snRNP complex assembly (GO:0000244)2.94204907
163fatty acid homeostasis (GO:0055089)2.93087422
164mitotic chromosome condensation (GO:0007076)2.90114267
165drinking behavior (GO:0042756)2.89701444
166positive regulation of dendritic spine morphogenesis (GO:0061003)2.87762496
167nuclear envelope organization (GO:0006998)2.86833669
168negative regulation of coagulation (GO:0050819)2.85924370
169regulation of centrosome cycle (GO:0046605)2.85289735
170regulation of mitotic spindle organization (GO:0060236)2.85175509
171response to vitamin A (GO:0033189)2.84954317
172anion homeostasis (GO:0055081)2.84576071
1734-hydroxyproline metabolic process (GO:0019471)2.83486955
174establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.81412572
175regulation of norepinephrine secretion (GO:0014061)2.79897377
176vitamin transmembrane transport (GO:0035461)2.79599662
177determination of adult lifespan (GO:0008340)2.73747711
178regulation of sister chromatid cohesion (GO:0007063)2.72394094
179chromatin assembly or disassembly (GO:0006333)2.72199193
180histone H4-K5 acetylation (GO:0043981)2.72137404
181histone H4-K8 acetylation (GO:0043982)2.72137404
182negative regulation of chromosome segregation (GO:0051985)2.72089147
183ribonucleoprotein complex biogenesis (GO:0022613)2.69341298
184dosage compensation (GO:0007549)2.68864083
185regulation of chromosome segregation (GO:0051983)2.68842798
186positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67735193
187positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67735193
188positive regulation of mitotic sister chromatid separation (GO:1901970)2.67735193
189histone H2A ubiquitination (GO:0033522)2.66512899
190ribosomal large subunit biogenesis (GO:0042273)2.65611169
191negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63350054
192establishment of chromosome localization (GO:0051303)2.63057217
193trophoblast giant cell differentiation (GO:0060707)2.62725171
194mRNA transport (GO:0051028)2.61742839
195response to UV-C (GO:0010225)2.60962298
196regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60470913
197spindle assembly involved in mitosis (GO:0090307)2.59525394
198DNA conformation change (GO:0071103)2.59439530
199telomere maintenance via semi-conservative replication (GO:0032201)2.58343823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.68021205
2E2F7_22180533_ChIP-Seq_HELA_Human7.64995771
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.14897476
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.11893242
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.87488185
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.63402882
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.53743384
8FOXA2_19822575_ChIP-Seq_HepG2_Human3.40552133
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.31343872
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.31343872
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.31343872
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10945022
13LXR_22158963_ChIP-Seq_LIVER_Mouse3.06369359
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01839702
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93453350
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.92286736
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.91348243
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.82807697
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.75058250
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.71295937
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66435069
22* HNF4A_19822575_ChIP-Seq_HepG2_Human2.59231872
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58120935
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58081067
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45649020
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.44006529
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38519357
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31253630
29CLOCK_20551151_ChIP-Seq_293T_Human2.28889027
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22558998
31SREBP1_19666523_ChIP-Seq_LIVER_Mouse2.16208999
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14887057
33NANOG_18555785_ChIP-Seq_MESCs_Mouse2.11816425
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.11664839
35TCF3_18692474_ChIP-Seq_MEFs_Mouse2.06689024
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04368405
37AR_21909140_ChIP-Seq_LNCAP_Human1.98730369
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.96768639
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96159207
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96103504
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94910016
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.92196285
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91495339
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90982969
45XRN2_22483619_ChIP-Seq_HELA_Human1.88674970
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87593486
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85735400
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84125303
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79930264
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79926384
51LXR_22292898_ChIP-Seq_THP-1_Human1.79838946
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79515595
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78437425
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76772839
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76400113
56TCF3_18692474_ChIP-Seq_MESCs_Mouse1.76257436
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.76061503
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.75942381
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.75516436
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75235916
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.73945750
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73679058
63* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71893450
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70915240
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68051489
66MYC_22102868_ChIP-Seq_BL_Human1.66634270
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64245667
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63410609
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62089533
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.61486840
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55066582
72TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53253108
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50348368
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47498539
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.46039162
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45963070
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45658145
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45655758
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45261323
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.43608319
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39453776
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38274946
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.37950860
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37304116
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36112338
86TTF2_22483619_ChIP-Seq_HELA_Human1.35137757
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33252261
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32790906
89GATA6_25053715_ChIP-Seq_YYC3_Human1.31868183
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.31716570
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.30701909
92* RACK7_27058665_Chip-Seq_MCF-7_Human1.30451347
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.29931371
94RARA_24833708_ChIP-Seq_LIVER_Mouse1.28840659
95SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28749566
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28666984
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26948230
98KDM5A_27292631_Chip-Seq_BREAST_Human1.26896577
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25151825
100DCP1A_22483619_ChIP-Seq_HELA_Human1.24816263
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23928608
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23620027
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22778556
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22078267
105GABP_19822575_ChIP-Seq_HepG2_Human1.21283109
106ZNF263_19887448_ChIP-Seq_K562_Human1.21215439
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20289130
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20223344
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18054262
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.16851765
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15948041
112P68_20966046_ChIP-Seq_HELA_Human1.15564809
113TFEB_21752829_ChIP-Seq_HELA_Human1.14706225
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14094675
115* GATA4_25053715_ChIP-Seq_YYC3_Human1.13641269
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13528608
117STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.13115887
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11809203
119NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11154807
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09495695
121VDR_23849224_ChIP-Seq_CD4+_Human1.08747764
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08741735
123RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08726211
124TP53_22127205_ChIP-Seq_IMR90_Human1.07716780
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.06859601
126RARB_24833708_ChIP-Seq_LIVER_Mouse1.06613553
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06520945
128YY1_21170310_ChIP-Seq_MESCs_Mouse1.06188336
129CIITA_25753668_ChIP-Seq_RAJI_Human1.06081524
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05626585
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05161404
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04750100
133NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03887348
134FOXP3_21729870_ChIP-Seq_TREG_Human1.03824904
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02785876
136ESR2_21235772_ChIP-Seq_MCF-7_Human1.02574765
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01614200
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99264275
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99218418
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98272188
141ATF3_27146783_Chip-Seq_COLON_Human0.98034151
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97745335
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97129713
144SMC4_20622854_ChIP-Seq_HELA_Human0.97022780
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96848160
146* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96460046
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95953262
148* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95877777
149UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95190771
150KDM2B_26808549_Chip-Seq_K562_Human0.94196032
151TET1_21451524_ChIP-Seq_MESCs_Mouse0.93379302
152SOX17_20123909_ChIP-Seq_XEN_Mouse0.91797880
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91208265
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90679444
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.90114155
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89957420
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88420672
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.87005107
159FOXP1_21924763_ChIP-Seq_HESCs_Human0.85139627
160ELK3_25401928_ChIP-Seq_HUVEC_Human0.84230444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.73424601
2MP0002139_abnormal_hepatobiliary_system4.73275545
3MP0005365_abnormal_bile_salt4.01558730
4MP0003195_calcinosis4.01520714
5MP0003123_paternal_imprinting3.90449027
6MP0000566_synostosis3.79916739
7MP0010329_abnormal_lipoprotein_level3.73820942
8MP0004957_abnormal_blastocyst_morpholog3.71051397
9MP0001666_abnormal_nutrient_absorption3.22878082
10MP0003693_abnormal_embryo_hatching3.22413303
11MP0004272_abnormal_basement_membrane3.15879611
12MP0003111_abnormal_nucleus_morphology3.15751924
13MP0004264_abnormal_extraembryonic_tissu3.02366952
14MP0003172_abnormal_lysosome_physiology2.98628248
15MP0002089_abnormal_postnatal_growth/wei2.94101522
16MP0010094_abnormal_chromosome_stability2.89776910
17MP0005451_abnormal_body_composition2.86430519
18MP0003077_abnormal_cell_cycle2.80755818
19MP0003121_genomic_imprinting2.72433190
20MP0003705_abnormal_hypodermis_morpholog2.60824111
21MP0001730_embryonic_growth_arrest2.57681724
22MP0010352_gastrointestinal_tract_polyps2.52245729
23MP0008057_abnormal_DNA_replication2.51552409
24MP0003941_abnormal_skin_development2.51284632
25MP0005085_abnormal_gallbladder_physiolo2.44665377
26MP0003119_abnormal_digestive_system2.39780504
27MP0004197_abnormal_fetal_growth/weight/2.36386497
28MP0002084_abnormal_developmental_patter2.33892040
29MP0008875_abnormal_xenobiotic_pharmacok2.32498655
30MP0005623_abnormal_meninges_morphology2.30360702
31MP0001672_abnormal_embryogenesis/_devel2.26957612
32MP0005380_embryogenesis_phenotype2.26957612
33* MP0002086_abnormal_extraembryonic_tissu2.23655131
34MP0005058_abnormal_lysosome_morphology2.15522148
35MP0005408_hypopigmentation2.13866054
36MP0004133_heterotaxia2.13307433
37MP0001697_abnormal_embryo_size2.12609829
38MP0002653_abnormal_ependyma_morphology2.10213968
39MP0003984_embryonic_growth_retardation2.09500962
40MP0003122_maternal_imprinting2.08092304
41MP0002088_abnormal_embryonic_growth/wei2.06530721
42MP0003567_abnormal_fetal_cardiomyocyte2.03293819
43MP0005076_abnormal_cell_differentiation2.02548985
44MP0002085_abnormal_embryonic_tissue2.02151305
45MP0008932_abnormal_embryonic_tissue2.01646140
46MP0000350_abnormal_cell_proliferation1.99919436
47MP0000537_abnormal_urethra_morphology1.96565862
48MP0010234_abnormal_vibrissa_follicle1.89420192
49MP0003566_abnormal_cell_adhesion1.82944223
50MP0003890_abnormal_embryonic-extraembry1.81369290
51MP0010030_abnormal_orbit_morphology1.73703467
52MP0009840_abnormal_foam_cell1.72211792
53MP0008058_abnormal_DNA_repair1.71724140
54MP0008007_abnormal_cellular_replicative1.70690653
55* MP0002080_prenatal_lethality1.70438963
56MP0009780_abnormal_chondrocyte_physiolo1.69695923
57MP0003252_abnormal_bile_duct1.63467760
58MP0005409_darkened_coat_color1.62857532
59MP0000609_abnormal_liver_physiology1.61447274
60MP0010307_abnormal_tumor_latency1.58393573
61MP0009053_abnormal_anal_canal1.54223506
62MP0001915_intracranial_hemorrhage1.52686066
63MP0002118_abnormal_lipid_homeostasis1.51172877
64MP0001293_anophthalmia1.50282455
65MP0005332_abnormal_amino_acid1.47828052
66MP0005257_abnormal_intraocular_pressure1.43537267
67MP0000639_abnormal_adrenal_gland1.39925859
68MP0003283_abnormal_digestive_organ1.39680088
69MP0002697_abnormal_eye_size1.38286495
70MP0003937_abnormal_limbs/digits/tail_de1.36577977
71MP0003806_abnormal_nucleotide_metabolis1.35902570
72MP0001661_extended_life_span1.33127051
73MP0002132_abnormal_respiratory_system1.30534854
74MP0003868_abnormal_feces_composition1.26235676
75MP0001849_ear_inflammation1.24660587
76MP0002111_abnormal_tail_morphology1.24204551
77MP0008877_abnormal_DNA_methylation1.23178916
78MP0002938_white_spotting1.16301779
79MP0009384_cardiac_valve_regurgitation1.13536076
80MP0009703_decreased_birth_body1.10874004
81MP0005023_abnormal_wound_healing1.10754945
82MP0005167_abnormal_blood-brain_barrier1.08692428
83MP0004185_abnormal_adipocyte_glucose1.08639279
84MP0000598_abnormal_liver_morphology1.07964185
85MP0005636_abnormal_mineral_homeostasis1.06815283
86MP0009672_abnormal_birth_weight1.03504220
87MP0003950_abnormal_plasma_membrane1.02601304
88MP0005220_abnormal_exocrine_pancreas1.01623467
89MP0008260_abnormal_autophagy1.00565329
90MP0003385_abnormal_body_wall0.99564688
91MP0003861_abnormal_nervous_system0.98606584
92MP0002925_abnormal_cardiovascular_devel0.98078064
93MP0000428_abnormal_craniofacial_morphol0.97948549
94MP0004858_abnormal_nervous_system0.97643155
95MP0002092_abnormal_eye_morphology0.96635494
96MP0001270_distended_abdomen0.96066591
97MP0003115_abnormal_respiratory_system0.96013177
98MP0000678_abnormal_parathyroid_gland0.95664830
99MP0003786_premature_aging0.95317708
100MP0000313_abnormal_cell_death0.94479390
101MP0003718_maternal_effect0.92464055
102MP0005501_abnormal_skin_physiology0.91533834
103MP0005084_abnormal_gallbladder_morpholo0.89952662
104MP0000432_abnormal_head_morphology0.89590128
105MP0002160_abnormal_reproductive_system0.88088692
106MP0000490_abnormal_crypts_of0.87501866
107MP0002796_impaired_skin_barrier0.87126826
108MP0004233_abnormal_muscle_weight0.85500037
109MP0001145_abnormal_male_reproductive0.85105434
110MP0000516_abnormal_urinary_system0.84553348
111MP0005367_renal/urinary_system_phenotyp0.84553348
112MP0001286_abnormal_eye_development0.84425771
113MP0004019_abnormal_vitamin_homeostasis0.83862968
114MP0003943_abnormal_hepatobiliary_system0.83050907
115MP0003315_abnormal_perineum_morphology0.82910696
116MP0003329_amyloid_beta_deposits0.82283491
117MP0002127_abnormal_cardiovascular_syste0.81777046
118MP0000534_abnormal_ureter_morphology0.81559779
119MP0003935_abnormal_craniofacial_develop0.81278437
120MP0000003_abnormal_adipose_tissue0.80870663
121MP0005384_cellular_phenotype0.80597996
122MP0003942_abnormal_urinary_system0.80528036
123MP0005319_abnormal_enzyme/_coenzyme0.80182498
124MP0010368_abnormal_lymphatic_system0.79354597
125MP0002210_abnormal_sex_determination0.78872750
126MP0000604_amyloidosis0.77635029
127MP0000858_altered_metastatic_potential0.75201488
128MP0003936_abnormal_reproductive_system0.74617381
129MP0006292_abnormal_olfactory_placode0.74311124
130MP0002019_abnormal_tumor_incidence0.74137498
131MP0009642_abnormal_blood_homeostasis0.73597498
132MP0003755_abnormal_palate_morphology0.73541958
133MP0005621_abnormal_cell_physiology0.73012267
134MP0002249_abnormal_larynx_morphology0.72109682
135MP0003221_abnormal_cardiomyocyte_apopto0.71324005
136MP0008438_abnormal_cutaneous_collagen0.70896498
137MP0000733_abnormal_muscle_development0.70262287
138MP0005379_endocrine/exocrine_gland_phen0.69732514
139MP0005377_hearing/vestibular/ear_phenot0.69556406
140MP0003878_abnormal_ear_physiology0.69556406
141MP0001764_abnormal_homeostasis0.66149782
142MP0000266_abnormal_heart_morphology0.65962486
143MP0006054_spinal_hemorrhage0.65483513
144MP0000653_abnormal_sex_gland0.64714572
145MP0009643_abnormal_urine_homeostasis0.64349029
146MP0003091_abnormal_cell_migration0.63640093
147MP0003453_abnormal_keratinocyte_physiol0.63348642
148MP0008770_decreased_survivor_rate0.63054537
149MP0002909_abnormal_adrenal_gland0.62622350
150MP0003787_abnormal_imprinting0.62610010
151MP0002269_muscular_atrophy0.62524373
152MP0005464_abnormal_platelet_physiology0.62467353
153MP0000358_abnormal_cell_content/0.62433917
154MP0001756_abnormal_urination0.62134291
155MP0002233_abnormal_nose_morphology0.61179551
156MP0001324_abnormal_eye_pigmentation0.60606213
157MP0005410_abnormal_fertilization0.60327548
158MP0003879_abnormal_hair_cell0.60213950
159MP0003183_abnormal_peptide_metabolism0.58673983
160MP0003953_abnormal_hormone_level0.58366567
161MP0003656_abnormal_erythrocyte_physiolo0.57675036
162MP0000371_diluted_coat_color0.57660231
163MP0002078_abnormal_glucose_homeostasis0.56571453
164MP0009115_abnormal_fat_cell0.52882146

Predicted human phenotypes

RankGene SetZ-score
1Joint hemorrhage (HP:0005261)6.36517937
2Prolonged partial thromboplastin time (HP:0003645)6.34959657
3Hypobetalipoproteinemia (HP:0003563)5.81472695
4Xanthomatosis (HP:0000991)4.75690439
5Hypercholesterolemia (HP:0003124)4.66088081
6Hemorrhage of the eye (HP:0011885)4.58266302
7Abnormality of the common coagulation pathway (HP:0010990)4.46116337
8Ependymoma (HP:0002888)4.41023110
9Complement deficiency (HP:0004431)4.12920268
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12772116
11Selective tooth agenesis (HP:0001592)4.00869673
12Hypolipoproteinemia (HP:0010981)3.81919420
13Missing ribs (HP:0000921)3.75487504
14Small epiphyses (HP:0010585)3.74282971
15Broad alveolar ridges (HP:0000187)3.64374010
16Menorrhagia (HP:0000132)3.53958883
17Acanthocytosis (HP:0001927)3.42467743
18Glomerulonephritis (HP:0000099)3.40297317
19Abnormality of carpal bone ossification (HP:0006257)3.39962002
20Asymmetry of the thorax (HP:0001555)3.26614207
21Abnormality of the labia minora (HP:0012880)3.26028690
22Absent radius (HP:0003974)3.22018388
23Aplasia/hypoplasia of the humerus (HP:0006507)3.21310238
24Spontaneous abortion (HP:0005268)3.21213883
25Colon cancer (HP:0003003)3.21185718
26Short humerus (HP:0005792)3.19965269
27Medulloblastoma (HP:0002885)3.14635634
28Vascular calcification (HP:0004934)3.10693992
29Vaginal fistula (HP:0004320)3.10500218
30Abnormality of complement system (HP:0005339)3.09430513
31Astrocytoma (HP:0009592)3.07855148
32Abnormality of the astrocytes (HP:0100707)3.07855148
33Absent forearm bone (HP:0003953)3.02500731
34Aplasia involving forearm bones (HP:0009822)3.02500731
35Deviation of the thumb (HP:0009603)3.02097858
36Broad palm (HP:0001169)3.01398413
37Epidermoid cyst (HP:0200040)2.98205678
38Cerebral aneurysm (HP:0004944)2.94061542
39Neoplasm of the oral cavity (HP:0100649)2.88292721
40Pancreatic islet-cell hyperplasia (HP:0004510)2.86039865
41Breast hypoplasia (HP:0003187)2.84621575
42Supernumerary spleens (HP:0009799)2.84149788
43Purpura (HP:0000979)2.82836431
44Rhabdomyosarcoma (HP:0002859)2.79226892
45Proximal placement of thumb (HP:0009623)2.77752570
46Hypophosphatemic rickets (HP:0004912)2.75319893
47Flat acetabular roof (HP:0003180)2.73572115
48Abnormal tarsal ossification (HP:0008369)2.73388982
49High anterior hairline (HP:0009890)2.72615898
50Agnosia (HP:0010524)2.69655278
51Cardiovascular calcification (HP:0011915)2.68396867
52Alacrima (HP:0000522)2.68283576
53Abnormality of the lumbar spine (HP:0100712)2.68222069
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67826368
55Systemic lupus erythematosus (HP:0002725)2.66239565
56Increased serum pyruvate (HP:0003542)2.65221994
57Abnormality of glycolysis (HP:0004366)2.64674407
58Hypoalphalipoproteinemia (HP:0003233)2.60267789
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60241508
6011 pairs of ribs (HP:0000878)2.56845756
61Birth length less than 3rd percentile (HP:0003561)2.56637847
62Epiphyseal dysplasia (HP:0002656)2.55871460
63Esophageal atresia (HP:0002032)2.55430422
64Abnormal ossification of hand bones (HP:0005921)2.54119655
65Oral leukoplakia (HP:0002745)2.51621015
66Mitral stenosis (HP:0001718)2.51207537
67Abdominal situs inversus (HP:0003363)2.51075364
68Abnormality of abdominal situs (HP:0011620)2.51075364
69Shawl scrotum (HP:0000049)2.49495287
70Protrusio acetabuli (HP:0003179)2.49248529
71Hepatoblastoma (HP:0002884)2.49127233
72Myocardial infarction (HP:0001658)2.48232121
73Neoplasm of striated muscle (HP:0009728)2.45959500
74Abnormal hand bone ossification (HP:0010660)2.45496541
75Glioma (HP:0009733)2.38893408
76Irregular epiphyses (HP:0010582)2.38242872
77Reticulocytopenia (HP:0001896)2.38065558
78Hypopigmentation of the fundus (HP:0007894)2.37696502
79Abnormality of the nasal septum (HP:0000419)2.36359684
80Impaired pain sensation (HP:0007328)2.35901574
81Abnormality of pain sensation (HP:0010832)2.35901574
82Pseudobulbar signs (HP:0002200)2.35296477
83Rib fusion (HP:0000902)2.35074207
84Abnormal number of incisors (HP:0011064)2.33742769
85Diastasis recti (HP:0001540)2.32995451
86Vertebral clefting (HP:0008428)2.32619220
87Aplasia/Hypoplasia of the spleen (HP:0010451)2.30880880
88Metaphyseal cupping (HP:0003021)2.28463965
89Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27921169
90Fused cervical vertebrae (HP:0002949)2.27909955
91Hypoglycemic coma (HP:0001325)2.27508007
92Hepatocellular carcinoma (HP:0001402)2.26443130
93Biliary tract neoplasm (HP:0100574)2.24074265
94Neonatal death (HP:0003811)2.22728380
95Flared iliac wings (HP:0002869)2.22483508
96Pili torti (HP:0003777)2.22378566
97Chromsome breakage (HP:0040012)2.22200593
98Trismus (HP:0000211)2.21088570
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.21019837
100Absent epiphyses (HP:0010577)2.21019837
101Skin nodule (HP:0200036)2.18114907
102Facial shape deformation (HP:0011334)2.18035324
103Potter facies (HP:0002009)2.18035324
104Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17687990
105Impulsivity (HP:0100710)2.17109536
106Hemiplegia (HP:0002301)2.15721923
107Preauricular skin tag (HP:0000384)2.14145467
108Gingival bleeding (HP:0000225)2.13886546
109Gonadal dysgenesis (HP:0000133)2.13432126
110Absent thumb (HP:0009777)2.12811728
111Abnormality of the salivary glands (HP:0010286)2.12434183
112Asplenia (HP:0001746)2.12113355
113Bifid scrotum (HP:0000048)2.10953007
114Patellar aplasia (HP:0006443)2.10377306
115Stenosis of the external auditory canal (HP:0000402)2.09443419
116Shallow orbits (HP:0000586)2.07628675
117Short 1st metacarpal (HP:0010034)2.06997773
118Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.06997773
119Enlarged kidneys (HP:0000105)2.06096552
120Limited elbow extension (HP:0001377)2.05627258
121Skull defect (HP:0001362)2.05353083
122Abnormality of the 1st metacarpal (HP:0010009)2.04571529
123Adenoma sebaceum (HP:0009720)2.04357839
124Angiofibromas (HP:0010615)2.04357839
125Short phalanx of the thumb (HP:0009660)2.04327668
126Abnormality of the acetabulum (HP:0003170)2.03145960
127Skin tags (HP:0010609)2.01955164
128Carpal bone hypoplasia (HP:0001498)2.01563779
129Biconcave vertebral bodies (HP:0004586)2.01479238
130Abnormality of the Achilles tendon (HP:0005109)2.01235628
131Deep venous thrombosis (HP:0002625)10.2600328
132Thrombophlebitis (HP:0004418)1.97804552
133Basal cell carcinoma (HP:0002671)1.97660395
134Aplasia/Hypoplasia of the patella (HP:0006498)1.97015049
135Decreased lacrimation (HP:0000633)1.97005706
136Renal duplication (HP:0000075)1.96968893
137Malignant gastrointestinal tract tumors (HP:0006749)1.96060148
138Gastrointestinal carcinoma (HP:0002672)1.96060148
139Increased nuchal translucency (HP:0010880)1.95789336
140Degeneration of anterior horn cells (HP:0002398)1.94383873
141Abnormality of the anterior horn cell (HP:0006802)1.94383873
142Ectopic kidney (HP:0000086)1.92760962
143Overlapping toe (HP:0001845)1.92190051
144Wide nose (HP:0000445)1.91781883
145Abnormality of the lower motor neuron (HP:0002366)1.91406731
146Atresia of the external auditory canal (HP:0000413)1.91184158
147Widely patent fontanelles and sutures (HP:0004492)1.89905929
148Fat malabsorption (HP:0002630)1.89095635
149Vertebral fusion (HP:0002948)1.88945467
150Neoplasm of the pancreas (HP:0002894)1.88407009
151Abnormality of the wing of the ilium (HP:0011867)1.88132818
152Abnormality of the proximal phalanges of the hand (HP:0009834)1.86872221
153Intrahepatic cholestasis (HP:0001406)1.85617848
154Multiple enchondromatosis (HP:0005701)1.85132513
155Megaloblastic anemia (HP:0001889)1.84796405
156Confusion (HP:0001289)1.84775093
157Abnormality of endocrine pancreas physiology (HP:0012093)1.84373372
158Abnormality of the pancreatic islet cells (HP:0006476)1.84373372
159Abnormality of the alveolar ridges (HP:0006477)1.83795120
160Amaurosis fugax (HP:0100576)1.83794075
161Arthropathy (HP:0003040)1.83458645
162Abnormality of the intrinsic pathway (HP:0010989)1.82355024
163Neonatal short-limb short stature (HP:0008921)1.81980048
164Porencephaly (HP:0002132)1.81381114
165Ovarian neoplasm (HP:0100615)1.81081036
166Supernumerary ribs (HP:0005815)1.80361912
167Osteomalacia (HP:0002749)1.80324178
168Meckel diverticulum (HP:0002245)1.80298834
169Rickets (HP:0002748)1.79706173
170Embryonal renal neoplasm (HP:0011794)1.79418834
171Abnormality of the vitreous humor (HP:0004327)1.79362545
172Hyperglycinemia (HP:0002154)1.78883529
173Supernumerary bones of the axial skeleton (HP:0009144)1.78062811
174Cholecystitis (HP:0001082)1.77653773
175Abnormal gallbladder physiology (HP:0012438)1.77653773
176Premature ovarian failure (HP:0008209)1.76850620
177Abnormal vertebral ossification (HP:0100569)1.76665987
178Horseshoe kidney (HP:0000085)1.76436629
179Spastic diplegia (HP:0001264)1.76360061
180Submucous cleft hard palate (HP:0000176)1.75892316
181Heterotopia (HP:0002282)1.75851552
182Bronchomalacia (HP:0002780)1.75583601
183Broad thumb (HP:0011304)1.75338728
184Vertebral compression fractures (HP:0002953)1.74374297
185Anal stenosis (HP:0002025)1.73450746
186Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72942700
187Vertebral hypoplasia (HP:0008417)1.72942700
188Spinal muscular atrophy (HP:0007269)1.72781939
189Large earlobe (HP:0009748)1.72357180
190Abnormality of the calcaneus (HP:0008364)1.72212476
191Pigmentary retinal degeneration (HP:0001146)1.71882903
192Late onset (HP:0003584)1.71838705
193Abnormality of the diencephalon (HP:0010662)1.70972703
194Poikilocytosis (HP:0004447)1.70841312
195Sandal gap (HP:0001852)1.70820269
196Ulnar bowing (HP:0003031)1.69311652
197Conjugated hyperbilirubinemia (HP:0002908)1.68498429
198Abnormal foot bone ossification (HP:0010675)1.66806759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR47.76563444
2CDK124.35879126
3FGFR34.25989612
4WNK43.77551866
5EPHA23.68037925
6CDC73.34678941
7RPS6KB23.19308022
8WEE13.18239502
9BUB12.75515104
10NEK22.61671565
11NEK12.61591894
12TTK2.51711591
13PLK42.30434007
14SMG12.10550581
15LATS22.04830222
16PKN22.04652935
17EEF2K1.99770220
18SCYL21.98860247
19IRAK31.96965204
20CDK71.92200083
21ERN11.91201019
22TSSK61.88584145
23FGFR21.83561858
24PLK11.78381306
25PASK1.73443728
26STK101.68112539
27BRD41.65959746
28DYRK1B1.64452784
29MAP3K81.63372155
30MAP3K101.62571109
31WNK11.58713806
32SIK11.55248533
33MAPK111.53387152
34SIK21.51843963
35CDK41.50874877
36ACVR1B1.49915389
37ALK1.48483358
38PAK41.41812414
39CHEK11.40429679
40TLK11.35594699
41MAPKAPK31.32082488
42CHEK21.30833135
43AURKB1.29571595
44STK38L1.26421316
45TGFBR11.23990988
46PRKCI1.23621890
47MTOR1.22538836
48ATR1.19204651
49AURKA1.18718853
50MAP2K21.17540032
51RET1.16897530
52PDPK11.16325783
53AKT31.16274518
54LATS11.16167731
55MET1.16103585
56MAP3K21.11781655
57TESK21.05926540
58PLK31.04627535
59ICK1.04617204
60AKT21.00796130
61PRKAA21.00623242
62PIK3CA0.99980303
63BRSK10.98750472
64FLT30.98545547
65CDK20.97078978
66PNCK0.96601139
67SRPK10.96036550
68PDGFRA0.95565284
69TRIB30.90949922
70TYRO30.88828474
71BRSK20.88209162
72ATM0.85995776
73CDK80.82330188
74CSNK1E0.80140891
75SGK4940.79749283
76SGK2230.79749283
77MKNK10.78866564
78BMX0.78442056
79PTK20.78367495
80FGFR10.76602386
81CAMK1D0.74077614
82MAP3K90.73597119
83MKNK20.73328669
84MELK0.72874443
85EIF2AK10.72001737
86LRRK20.71676896
87PIM10.71636958
88FGR0.71268046
89PAK10.70346938
90PDK10.70078822
91PRKAA10.68975434
92PTK60.68767369
93RPS6KB10.67249776
94CDK60.66744202
95ERBB20.65037096
96STK30.63670036
97CDK10.62948584
98STK40.62288925
99DYRK30.61392714
100RPS6KA40.59448627
101SGK30.59176708
102CSNK2A20.58679570
103CSNK1D0.57018931
104DDR20.56122451
105RIPK10.54981289
106GRK60.53640945
107SGK10.53337200
108FER0.52618218
109MST40.51571739
110PAK20.51264997
111KSR20.51204224
112CDC42BPA0.49755058
113BRAF0.49326818
114MAP3K10.49090051
115MAP3K30.47145881
116EPHA40.47028586
117KSR10.46154101
118PRKG20.46026560
119MAP3K110.45717893
120TESK10.45417887
121MAP2K10.43402595
122PRKDC0.43314199
123TTN0.42857543
124NTRK30.42087804
125MAP2K30.41810230
126CDK90.40559302
127NME20.39519493
128LIMK10.39068583
129PRKD30.38945215
130MAPK140.38870369
131AKT10.38841751
132MAPK10.38496113
133MAP3K70.37273534
134ERBB40.37086429
135STK390.36953389
136CSNK2A10.35620785
137VRK10.33765577
138MATK0.33509167
139NTRK20.33508563
140MARK20.33159788
141SGK20.32629317
142NME10.32203948
143CAMK1G0.30422255
144MAPKAPK50.29965808
145MAP2K60.28527517
146PDK20.27678880
147CAMK40.27625363
148LMTK20.26340027
149CDK150.24490191
150SRC0.23324302
151TGFBR20.22144690
152PBK0.21692915
153CDK11A0.20719839

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.93870524
2DNA replication_Homo sapiens_hsa030303.92796711
3Mismatch repair_Homo sapiens_hsa034303.81990579
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65427460
5Steroid biosynthesis_Homo sapiens_hsa001003.44350434
6RNA transport_Homo sapiens_hsa030133.37758570
7One carbon pool by folate_Homo sapiens_hsa006703.35792913
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.28350487
9Spliceosome_Homo sapiens_hsa030403.01031656
10Other glycan degradation_Homo sapiens_hsa005112.85520491
11Cell cycle_Homo sapiens_hsa041102.59680675
12Arginine biosynthesis_Homo sapiens_hsa002202.57285634
13Nucleotide excision repair_Homo sapiens_hsa034202.55163400
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54501832
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.49274516
16Base excision repair_Homo sapiens_hsa034102.22030451
17Fatty acid biosynthesis_Homo sapiens_hsa000612.19659043
18Homologous recombination_Homo sapiens_hsa034402.08869498
19mRNA surveillance pathway_Homo sapiens_hsa030152.02574580
20Ribosome_Homo sapiens_hsa030102.01870469
21RNA polymerase_Homo sapiens_hsa030201.99435144
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.96330710
23PPAR signaling pathway_Homo sapiens_hsa033201.92988916
24Fatty acid metabolism_Homo sapiens_hsa012121.91960899
25Hippo signaling pathway_Homo sapiens_hsa043901.84720449
26Phenylalanine metabolism_Homo sapiens_hsa003601.76634904
27Vitamin B6 metabolism_Homo sapiens_hsa007501.73537215
28Fanconi anemia pathway_Homo sapiens_hsa034601.70056464
29Systemic lupus erythematosus_Homo sapiens_hsa053221.69579965
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68931663
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.67401546
32RNA degradation_Homo sapiens_hsa030181.61774352
33p53 signaling pathway_Homo sapiens_hsa041151.60055389
34Fatty acid degradation_Homo sapiens_hsa000711.60017398
35Small cell lung cancer_Homo sapiens_hsa052221.56883969
36Basal cell carcinoma_Homo sapiens_hsa052171.55821009
37* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55238024
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51576145
39N-Glycan biosynthesis_Homo sapiens_hsa005101.48841428
40Histidine metabolism_Homo sapiens_hsa003401.46544345
41Basal transcription factors_Homo sapiens_hsa030221.43329704
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42540295
43Non-homologous end-joining_Homo sapiens_hsa034501.38045260
44Biosynthesis of amino acids_Homo sapiens_hsa012301.37156186
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33531581
46Pyrimidine metabolism_Homo sapiens_hsa002401.33165852
47Proteasome_Homo sapiens_hsa030501.25590589
48Viral carcinogenesis_Homo sapiens_hsa052031.25468840
49ABC transporters_Homo sapiens_hsa020101.25196504
50Thyroid cancer_Homo sapiens_hsa052161.24504062
51Pyruvate metabolism_Homo sapiens_hsa006201.24474323
52Tyrosine metabolism_Homo sapiens_hsa003501.18947116
53Hedgehog signaling pathway_Homo sapiens_hsa043401.18750572
54Bile secretion_Homo sapiens_hsa049761.17762844
55MicroRNAs in cancer_Homo sapiens_hsa052061.17181633
56Adherens junction_Homo sapiens_hsa045201.16988699
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.16345267
58Starch and sucrose metabolism_Homo sapiens_hsa005001.16065420
59Tight junction_Homo sapiens_hsa045301.15517057
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13011496
61Bladder cancer_Homo sapiens_hsa052191.11064318
62Renin-angiotensin system_Homo sapiens_hsa046141.10141409
63TGF-beta signaling pathway_Homo sapiens_hsa043501.09990587
64Oocyte meiosis_Homo sapiens_hsa041141.09830119
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06486416
66Thyroid hormone synthesis_Homo sapiens_hsa049181.04894882
67Selenocompound metabolism_Homo sapiens_hsa004501.04109255
68Lysine degradation_Homo sapiens_hsa003100.99608192
69Nitrogen metabolism_Homo sapiens_hsa009100.99215076
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.98013950
71ECM-receptor interaction_Homo sapiens_hsa045120.96136640
72Staphylococcus aureus infection_Homo sapiens_hsa051500.93310606
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92819338
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88572636
75HTLV-I infection_Homo sapiens_hsa051660.87985292
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84349688
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.84258358
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84243465
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83727871
80Sphingolipid metabolism_Homo sapiens_hsa006000.82778176
81Epstein-Barr virus infection_Homo sapiens_hsa051690.80942076
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80326367
83Notch signaling pathway_Homo sapiens_hsa043300.78236777
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78040719
85Alcoholism_Homo sapiens_hsa050340.77811757
86Pathways in cancer_Homo sapiens_hsa052000.77599941
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76982589
88Proteoglycans in cancer_Homo sapiens_hsa052050.76561473
89mTOR signaling pathway_Homo sapiens_hsa041500.75877905
90Carbon metabolism_Homo sapiens_hsa012000.74884839
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72236775
92Antigen processing and presentation_Homo sapiens_hsa046120.71722194
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71420459
94Fatty acid elongation_Homo sapiens_hsa000620.70486257
95Peroxisome_Homo sapiens_hsa041460.67175002
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.67170772
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66966570
98Focal adhesion_Homo sapiens_hsa045100.65608146
99Colorectal cancer_Homo sapiens_hsa052100.65503991
100Propanoate metabolism_Homo sapiens_hsa006400.65216669
101Glycerolipid metabolism_Homo sapiens_hsa005610.64778555
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.64043186
103Insulin resistance_Homo sapiens_hsa049310.63460260
104Amoebiasis_Homo sapiens_hsa051460.63428608
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62506229
106Fructose and mannose metabolism_Homo sapiens_hsa000510.59777466
107Galactose metabolism_Homo sapiens_hsa000520.59729021
108Butanoate metabolism_Homo sapiens_hsa006500.59038521
109Wnt signaling pathway_Homo sapiens_hsa043100.58136107
110Glucagon signaling pathway_Homo sapiens_hsa049220.57959225
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57719020
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54353731
113Melanoma_Homo sapiens_hsa052180.54222302
114HIF-1 signaling pathway_Homo sapiens_hsa040660.53439351
115Folate biosynthesis_Homo sapiens_hsa007900.52023816
116Pentose phosphate pathway_Homo sapiens_hsa000300.51842023
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.51646368
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50732183
119Insulin signaling pathway_Homo sapiens_hsa049100.49946754
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49042679
121Purine metabolism_Homo sapiens_hsa002300.49010750
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48983469
123Herpes simplex infection_Homo sapiens_hsa051680.48771958
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48349265
125AMPK signaling pathway_Homo sapiens_hsa041520.47873604
126Arginine and proline metabolism_Homo sapiens_hsa003300.47281425
127Endometrial cancer_Homo sapiens_hsa052130.47186221
128Prostate cancer_Homo sapiens_hsa052150.47136316
129Apoptosis_Homo sapiens_hsa042100.46265533
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45838869
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43230378
132Sulfur relay system_Homo sapiens_hsa041220.43209402
133Chronic myeloid leukemia_Homo sapiens_hsa052200.42457129
134Renal cell carcinoma_Homo sapiens_hsa052110.42436514
135Mineral absorption_Homo sapiens_hsa049780.42248486
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40377118
137Metabolic pathways_Homo sapiens_hsa011000.39391758
138Prion diseases_Homo sapiens_hsa050200.38731158
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38581235
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34620257
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.31205072
142Rap1 signaling pathway_Homo sapiens_hsa040150.31185416
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.30909628
144Chemical carcinogenesis_Homo sapiens_hsa052040.30337252
145Non-small cell lung cancer_Homo sapiens_hsa052230.28006437
146Vitamin digestion and absorption_Homo sapiens_hsa049770.27365023
147Acute myeloid leukemia_Homo sapiens_hsa052210.24691580
148Legionellosis_Homo sapiens_hsa051340.24514627
149Glutathione metabolism_Homo sapiens_hsa004800.22824082
150Retinol metabolism_Homo sapiens_hsa008300.22224692
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21739002
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.21330504
153Vibrio cholerae infection_Homo sapiens_hsa051100.21314534
154VEGF signaling pathway_Homo sapiens_hsa043700.19356558
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19283209
156Pertussis_Homo sapiens_hsa051330.18896405
157Fat digestion and absorption_Homo sapiens_hsa049750.18747405
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18648794
159Tryptophan metabolism_Homo sapiens_hsa003800.18319129

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