DUT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.80704632
2telomere maintenance via semi-conservative replication (GO:0032201)5.60451108
3DNA strand elongation (GO:0022616)5.52502625
4DNA replication initiation (GO:0006270)5.38641074
5DNA deamination (GO:0045006)5.29951046
6DNA unwinding involved in DNA replication (GO:0006268)5.24232982
7ribosomal small subunit assembly (GO:0000028)5.04539713
8telomere maintenance via recombination (GO:0000722)4.92332129
9DNA replication checkpoint (GO:0000076)4.78526090
10viral transcription (GO:0019083)4.78209023
11translational termination (GO:0006415)4.68047732
12mitotic recombination (GO:0006312)4.65772375
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.63974702
14maturation of SSU-rRNA (GO:0030490)4.48931112
15telomere maintenance via telomere lengthening (GO:0010833)4.36424628
16protein localization to kinetochore (GO:0034501)4.34720193
17CENP-A containing nucleosome assembly (GO:0034080)4.32985156
18chromatin remodeling at centromere (GO:0031055)4.32106968
19nucleotide-excision repair, DNA gap filling (GO:0006297)4.28713273
20ribosomal small subunit biogenesis (GO:0042274)4.26005982
21translational elongation (GO:0006414)4.25638772
22ATP synthesis coupled proton transport (GO:0015986)4.11420755
23energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11420755
24folic acid-containing compound biosynthetic process (GO:0009396)4.11370666
25formation of translation preinitiation complex (GO:0001731)4.10843522
26DNA replication-dependent nucleosome assembly (GO:0006335)4.08728890
27DNA replication-dependent nucleosome organization (GO:0034723)4.08728890
28nucleobase biosynthetic process (GO:0046112)4.03640673
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.03636699
30ribosomal large subunit biogenesis (GO:0042273)4.02019516
31translational initiation (GO:0006413)4.01157922
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.98689418
33DNA replication-independent nucleosome organization (GO:0034724)3.97215591
34DNA replication-independent nucleosome assembly (GO:0006336)3.97215591
35regulation of mitochondrial translation (GO:0070129)3.95430034
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92990964
37cotranslational protein targeting to membrane (GO:0006613)3.92812297
38protein targeting to ER (GO:0045047)3.91782832
39protein localization to chromosome, centromeric region (GO:0071459)3.88501716
40mitotic metaphase plate congression (GO:0007080)3.87791285
41* pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.87768626
42kinetochore organization (GO:0051383)3.84136906
43ribonucleoprotein complex biogenesis (GO:0022613)3.75273963
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71478113
45spliceosomal snRNP assembly (GO:0000387)3.70657962
46cellular protein complex disassembly (GO:0043624)3.69760499
47DNA ligation (GO:0006266)3.69654366
48establishment of integrated proviral latency (GO:0075713)3.69305360
49protein localization to endoplasmic reticulum (GO:0070972)3.67576464
50purine nucleobase biosynthetic process (GO:0009113)3.67562663
51mitotic nuclear envelope disassembly (GO:0007077)3.66053801
52viral life cycle (GO:0019058)3.65749307
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.65460096
54chaperone-mediated protein transport (GO:0072321)3.63335357
55oxidative phosphorylation (GO:0006119)3.60698535
56kinetochore assembly (GO:0051382)3.58174897
57IMP biosynthetic process (GO:0006188)3.55453354
58histone exchange (GO:0043486)3.53650877
59ribosome biogenesis (GO:0042254)3.52007068
60pseudouridine synthesis (GO:0001522)3.48885287
61* pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.48338126
62pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.46504070
63rRNA processing (GO:0006364)3.46235093
64base-excision repair (GO:0006284)3.44467280
65metaphase plate congression (GO:0051310)3.44034047
66transcription-coupled nucleotide-excision repair (GO:0006283)3.40950228
67spliceosomal complex assembly (GO:0000245)3.40834306
68establishment of viral latency (GO:0019043)3.38050873
69membrane disassembly (GO:0030397)3.37506983
70nuclear envelope disassembly (GO:0051081)3.37506983
71protein complex disassembly (GO:0043241)3.37318397
72respiratory electron transport chain (GO:0022904)3.37133170
73cellular component biogenesis (GO:0044085)3.35863211
74nucleobase-containing small molecule interconversion (GO:0015949)3.35526027
75rRNA metabolic process (GO:0016072)3.34550188
76mitotic chromosome condensation (GO:0007076)3.34233196
77* deoxyribonucleotide biosynthetic process (GO:0009263)3.33827292
78* pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.32810038
79mitotic sister chromatid segregation (GO:0000070)3.31614044
80attachment of spindle microtubules to kinetochore (GO:0008608)3.30235811
81proteasome assembly (GO:0043248)3.28693989
82translation (GO:0006412)3.26660093
83electron transport chain (GO:0022900)3.25773550
84ribosome assembly (GO:0042255)3.25227661
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.23418413
86nuclear-transcribed mRNA catabolic process (GO:0000956)3.23118023
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22551032
88regulation of nuclear cell cycle DNA replication (GO:0033262)3.22030884
89telomere organization (GO:0032200)3.21850271
90telomere maintenance (GO:0000723)3.21693813
91macromolecular complex disassembly (GO:0032984)3.20318594
92negative regulation of RNA splicing (GO:0033119)3.20309469
93chromatin assembly or disassembly (GO:0006333)3.20153108
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19758732
95protein targeting to membrane (GO:0006612)3.18932968
96DNA duplex unwinding (GO:0032508)3.18376612
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18121412
98DNA geometric change (GO:0032392)3.16466567
99IMP metabolic process (GO:0046040)3.15711451
100protein targeting to mitochondrion (GO:0006626)3.15606405
101DNA topological change (GO:0006265)3.15561675
102G1/S transition of mitotic cell cycle (GO:0000082)3.14657857
103cell cycle G1/S phase transition (GO:0044843)3.14657857
104translesion synthesis (GO:0019985)3.14277110
105negative regulation of mRNA processing (GO:0050686)3.13976595
1062-deoxyribonucleotide biosynthetic process (GO:0009265)3.13722914
107* deoxyribose phosphate biosynthetic process (GO:0046385)3.13722914
108* deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.12863012
109establishment of chromosome localization (GO:0051303)3.12442054
110termination of RNA polymerase II transcription (GO:0006369)3.11977218
111somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09611932
112somatic hypermutation of immunoglobulin genes (GO:0016446)3.09611932
113viral mRNA export from host cell nucleus (GO:0046784)3.07253172
114rRNA modification (GO:0000154)3.06801539
115mRNA catabolic process (GO:0006402)3.06503094
116mitochondrial respiratory chain complex I assembly (GO:0032981)3.05277150
117NADH dehydrogenase complex assembly (GO:0010257)3.05277150
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05277150
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04712134
120mismatch repair (GO:0006298)3.04604726
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04583494
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04172429
123RNA catabolic process (GO:0006401)3.04160547
124mitochondrial respiratory chain complex assembly (GO:0033108)3.02692582
125negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02551251
126nuclear pore organization (GO:0006999)2.99876074
127protein complex biogenesis (GO:0070271)2.98919896
128RNA splicing, via transesterification reactions (GO:0000375)2.98764321
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98390704
130mRNA splicing, via spliceosome (GO:0000398)2.98390704
131sister chromatid segregation (GO:0000819)2.98137342
132guanosine-containing compound biosynthetic process (GO:1901070)2.98047333
133* deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98014108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human9.05730715
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51516798
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05882246
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.87873102
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85157105
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25478078
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21948089
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08063563
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.01187962
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97588869
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90612675
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.88135193
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82791381
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.82680200
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63075077
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60596899
17XRN2_22483619_ChIP-Seq_HELA_Human2.46624061
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33453101
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27170003
20VDR_23849224_ChIP-Seq_CD4+_Human2.24342116
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17540039
22AR_21909140_ChIP-Seq_LNCAP_Human2.14012204
23* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10380408
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07264226
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06809340
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05306853
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.01310389
28FOXP3_21729870_ChIP-Seq_TREG_Human2.00370063
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94376495
30TTF2_22483619_ChIP-Seq_HELA_Human1.93201557
31GABP_19822575_ChIP-Seq_HepG2_Human1.92090455
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91384800
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90507121
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86190803
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85972192
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83287480
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73452843
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72631186
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71185902
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69214506
41CIITA_25753668_ChIP-Seq_RAJI_Human1.65663592
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65141611
43MYC_22102868_ChIP-Seq_BL_Human1.64660344
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60804534
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.57748471
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56940975
47ELK1_19687146_ChIP-ChIP_HELA_Human1.53522153
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.52763276
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49818038
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48260021
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47256497
52KDM5A_27292631_Chip-Seq_BREAST_Human1.42240733
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.40889152
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38862404
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36586218
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35708346
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35390160
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32793473
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31446012
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31119493
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30549173
62* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23799896
63* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22156018
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17647935
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16818269
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15359031
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14901008
68VDR_21846776_ChIP-Seq_THP-1_Human1.14429269
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13839059
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13241751
71MYC_18940864_ChIP-ChIP_HL60_Human1.10930653
72ZNF263_19887448_ChIP-Seq_K562_Human1.10137611
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10085377
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09325989
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08509265
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08375524
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07979618
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07674019
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.06676712
80TFEB_21752829_ChIP-Seq_HELA_Human1.04052996
81* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02372287
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.01710616
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99763785
84* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97841156
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97615241
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96531752
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96357585
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94712384
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92307111
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90359501
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90222331
92FOXP1_21924763_ChIP-Seq_HESCs_Human0.89947099
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88608155
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87895205
95SPI1_23547873_ChIP-Seq_NB4_Human0.87107843
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85304430
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84427877
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84068599
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.82024947
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80601191
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80472604
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79422832
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78642072
104TET1_21451524_ChIP-Seq_MESCs_Mouse0.78527829
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78120154
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76677302
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.76026727
108IRF1_19129219_ChIP-ChIP_H3396_Human0.75631014
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75339620
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74699847
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72567281
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71945598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.91228261
2MP0010094_abnormal_chromosome_stability5.24280196
3MP0004957_abnormal_blastocyst_morpholog4.90750273
4MP0003111_abnormal_nucleus_morphology4.72943779
5MP0008057_abnormal_DNA_replication4.32907938
6MP0003077_abnormal_cell_cycle4.30636361
7MP0008058_abnormal_DNA_repair3.59278420
8MP0008007_abnormal_cellular_replicative2.99588229
9MP0008932_abnormal_embryonic_tissue2.92997078
10MP0002396_abnormal_hematopoietic_system2.63640584
11MP0003123_paternal_imprinting2.36411426
12MP0000350_abnormal_cell_proliferation2.35146269
13MP0001730_embryonic_growth_arrest2.33647039
14MP0009697_abnormal_copulation2.17467177
15MP0008877_abnormal_DNA_methylation2.13496090
16MP0000490_abnormal_crypts_of2.06816432
17MP0010352_gastrointestinal_tract_polyps1.96100129
18MP0003786_premature_aging1.86136406
19MP0001697_abnormal_embryo_size1.76394762
20MP0002163_abnormal_gland_morphology1.75450108
21MP0010307_abnormal_tumor_latency1.73725305
22MP0002080_prenatal_lethality1.63837729
23MP0000313_abnormal_cell_death1.63783425
24MP0001672_abnormal_embryogenesis/_devel1.62716837
25MP0005380_embryogenesis_phenotype1.62716837
26MP0002019_abnormal_tumor_incidence1.61175965
27MP0006054_spinal_hemorrhage1.60052525
28MP0003806_abnormal_nucleotide_metabolis1.58491506
29MP0002085_abnormal_embryonic_tissue1.50077618
30MP0004808_abnormal_hematopoietic_stem1.49619628
31MP0006292_abnormal_olfactory_placode1.48520824
32MP0000372_irregular_coat_pigmentation1.47206098
33MP0009379_abnormal_foot_pigmentation1.46152559
34MP0005397_hematopoietic_system_phenotyp1.46015358
35MP0001545_abnormal_hematopoietic_system1.46015358
36MP0009333_abnormal_splenocyte_physiolog1.45146046
37MP0003984_embryonic_growth_retardation1.43955255
38MP0003763_abnormal_thymus_physiology1.41422250
39MP0002088_abnormal_embryonic_growth/wei1.39689835
40MP0002877_abnormal_melanocyte_morpholog1.37115104
41MP0003718_maternal_effect1.35953204
42MP0002084_abnormal_developmental_patter1.31094718
43MP0000703_abnormal_thymus_morphology1.29416592
44MP0002086_abnormal_extraembryonic_tissu1.27279554
45MP0004185_abnormal_adipocyte_glucose1.26171770
46MP0003567_abnormal_fetal_cardiomyocyte1.22950139
47MP0002210_abnormal_sex_determination1.22872062
48MP0003890_abnormal_embryonic-extraembry1.22849263
49MP0002398_abnormal_bone_marrow1.18192538
50MP0001293_anophthalmia1.17646240
51MP0010030_abnormal_orbit_morphology1.17286249
52MP0003121_genomic_imprinting1.16566518
53MP0004197_abnormal_fetal_growth/weight/1.16498937
54MP0003315_abnormal_perineum_morphology1.14436525
55MP0001881_abnormal_mammary_gland1.12156401
56MP0002722_abnormal_immune_system1.11524798
57MP0001145_abnormal_male_reproductive1.11423280
58MP0002160_abnormal_reproductive_system1.10671938
59MP0008995_early_reproductive_senescence1.10181886
60MP0001529_abnormal_vocalization1.10065499
61MP0002234_abnormal_pharynx_morphology1.08814561
62MP0003186_abnormal_redox_activity1.07691046
63MP0000689_abnormal_spleen_morphology1.04019562
64MP0000358_abnormal_cell_content/1.03970336
65MP0006036_abnormal_mitochondrial_physio1.02417597
66MP0005379_endocrine/exocrine_gland_phen1.00449019
67MP0002132_abnormal_respiratory_system0.99609332
68MP0001764_abnormal_homeostasis0.98654201
69MP0005645_abnormal_hypothalamus_physiol0.97888846
70MP0001929_abnormal_gametogenesis0.95727177
71MP0005501_abnormal_skin_physiology0.95253725
72MP0000653_abnormal_sex_gland0.94874448
73MP0004133_heterotaxia0.93254692
74MP0002009_preneoplasia0.92541803
75MP0002102_abnormal_ear_morphology0.92274575
76MP0000858_altered_metastatic_potential0.91889004
77MP0002429_abnormal_blood_cell0.91802784
78MP0004147_increased_porphyrin_level0.91403940
79MP0003656_abnormal_erythrocyte_physiolo0.91327663
80MP0006035_abnormal_mitochondrial_morpho0.88493837
81MP0006072_abnormal_retinal_apoptosis0.87746266
82MP0001188_hyperpigmentation0.85683099
83MP0008789_abnormal_olfactory_epithelium0.85281719
84MP0002653_abnormal_ependyma_morphology0.84638307
85MP0005389_reproductive_system_phenotype0.83634844
86MP0005075_abnormal_melanosome_morpholog0.82289034
87MP0009672_abnormal_birth_weight0.81903079
88MP0003119_abnormal_digestive_system0.80519255
89MP0005174_abnormal_tail_pigmentation0.79387935
90MP0001119_abnormal_female_reproductive0.77989535
91MP0000537_abnormal_urethra_morphology0.77424589
92MP0005384_cellular_phenotype0.74952264
93MP0001853_heart_inflammation0.73666131
94MP0000716_abnormal_immune_system0.72285610
95MP0005084_abnormal_gallbladder_morpholo0.71398990
96MP0001727_abnormal_embryo_implantation0.71303939
97MP0005076_abnormal_cell_differentiation0.71180786
98MP0002095_abnormal_skin_pigmentation0.70603810
99MP0001346_abnormal_lacrimal_gland0.68121034
100MP0005220_abnormal_exocrine_pancreas0.68060101
101MP0003221_abnormal_cardiomyocyte_apopto0.67897709
102MP0000477_abnormal_intestine_morphology0.67397317
103MP0001905_abnormal_dopamine_level0.66859942
104MP0001835_abnormal_antigen_presentation0.66215535
105MP0002938_white_spotting0.66205053
106MP0002111_abnormal_tail_morphology0.65022973
107MP0005621_abnormal_cell_physiology0.62612302
108MP0001915_intracranial_hemorrhage0.62606325
109MP0005266_abnormal_metabolism0.61306584
110MP0002638_abnormal_pupillary_reflex0.60171692
111MP0001661_extended_life_span0.59101414
112MP0005394_taste/olfaction_phenotype0.58733164
113MP0005499_abnormal_olfactory_system0.58733164
114MP0002420_abnormal_adaptive_immunity0.58216836
115MP0001919_abnormal_reproductive_system0.57200210
116MP0002006_tumorigenesis0.56794936
117MP0001819_abnormal_immune_cell0.56553653
118MP0002075_abnormal_coat/hair_pigmentati0.56136000
119MP0000681_abnormal_thyroid_gland0.55816041
120MP0002083_premature_death0.54200431
121MP0003787_abnormal_imprinting0.54042059
122MP0003698_abnormal_male_reproductive0.53596982
123MP0002166_altered_tumor_susceptibility0.52889343
124MP0001286_abnormal_eye_development0.52271307
125MP0009703_decreased_birth_body0.51860306
126MP0008770_decreased_survivor_rate0.51012153
127MP0002092_abnormal_eye_morphology0.48372930
128MP0009278_abnormal_bone_marrow0.48003542
129MP0009053_abnormal_anal_canal0.47417704
130MP0002405_respiratory_system_inflammati0.47314806
131MP0002751_abnormal_autonomic_nervous0.47292495
132MP0001186_pigmentation_phenotype0.46183545

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.91175683
2Abnormal number of erythroid precursors (HP:0012131)5.78166995
3Birth length less than 3rd percentile (HP:0003561)5.54020560
4Reticulocytopenia (HP:0001896)5.36469605
5Abnormal mitochondria in muscle tissue (HP:0008316)4.72417154
6Acute necrotizing encephalopathy (HP:0006965)4.69077227
7Mitochondrial inheritance (HP:0001427)4.31774115
8Oral leukoplakia (HP:0002745)4.30033687
9Acute encephalopathy (HP:0006846)4.21846644
10Breast hypoplasia (HP:0003187)4.04402592
11Aplastic anemia (HP:0001915)3.96702427
12Increased CSF lactate (HP:0002490)3.91545024
13Chromsome breakage (HP:0040012)3.80601573
14Increased hepatocellular lipid droplets (HP:0006565)3.79747534
15Hepatic necrosis (HP:0002605)3.73375500
16Increased intramyocellular lipid droplets (HP:0012240)3.69864145
17Pallor (HP:0000980)3.69829123
18Progressive macrocephaly (HP:0004481)3.67237229
19Colon cancer (HP:0003003)3.66787879
20Macrocytic anemia (HP:0001972)3.63123166
21Lipid accumulation in hepatocytes (HP:0006561)3.61010548
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60649071
23Increased muscle lipid content (HP:0009058)3.36693989
24Patellar aplasia (HP:0006443)3.33829847
25Cerebral edema (HP:0002181)3.29408377
26Abnormality of chromosome stability (HP:0003220)3.22677633
27Abnormality of the preputium (HP:0100587)3.22354236
28Meckel diverticulum (HP:0002245)3.21304453
29Selective tooth agenesis (HP:0001592)3.18381030
30Aplasia/Hypoplasia of the patella (HP:0006498)3.11832852
31Abnormality of the ileum (HP:0001549)3.11120526
32Medulloblastoma (HP:0002885)3.10692985
33Rough bone trabeculation (HP:0100670)3.03866854
34Absent thumb (HP:0009777)3.03086886
35Lactic acidosis (HP:0003128)2.97948249
36Microretrognathia (HP:0000308)2.96966310
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.92633020
38Carpal bone hypoplasia (HP:0001498)2.91528684
39Ependymoma (HP:0002888)2.91160998
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.90779707
41Degeneration of anterior horn cells (HP:0002398)2.82541256
42Abnormality of the anterior horn cell (HP:0006802)2.82541256
43Exercise intolerance (HP:0003546)2.82274580
44Premature graying of hair (HP:0002216)2.79375693
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78131443
46Renal Fanconi syndrome (HP:0001994)2.77680098
47Myelodysplasia (HP:0002863)2.76753787
48Respiratory failure (HP:0002878)2.66072865
493-Methylglutaconic aciduria (HP:0003535)2.64809134
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61628790
51B lymphocytopenia (HP:0010976)2.60821666
52Rhabdomyosarcoma (HP:0002859)2.60698565
5311 pairs of ribs (HP:0000878)2.60326445
54Neoplasm of the pancreas (HP:0002894)2.57773392
55Agnosia (HP:0010524)2.57500107
56Duodenal stenosis (HP:0100867)2.56259434
57Small intestinal stenosis (HP:0012848)2.56259434
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55795882
59Dicarboxylic aciduria (HP:0003215)2.55795882
60Bone marrow hypocellularity (HP:0005528)2.55515705
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54914607
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54914607
63Cellular immunodeficiency (HP:0005374)2.51445880
64Abnormal number of incisors (HP:0011064)2.47329383
65Absent radius (HP:0003974)2.45637898
66Testicular atrophy (HP:0000029)2.44667142
67Cerebral hypomyelination (HP:0006808)2.44617805
68Agammaglobulinemia (HP:0004432)2.44535477
69Leukodystrophy (HP:0002415)2.43792656
70Respiratory difficulties (HP:0002880)2.41823186
71Exertional dyspnea (HP:0002875)2.39369771
72Panhypogammaglobulinemia (HP:0003139)2.37897001
73Abnormality of reticulocytes (HP:0004312)2.37510993
74Multiple enchondromatosis (HP:0005701)2.35798679
75Ragged-red muscle fibers (HP:0003200)2.35743622
76Pancytopenia (HP:0001876)2.34991540
77Triphalangeal thumb (HP:0001199)2.33699514
78Trismus (HP:0000211)2.33340819
79Horseshoe kidney (HP:0000085)2.31452047
80Tracheoesophageal fistula (HP:0002575)2.30179123
81Basal cell carcinoma (HP:0002671)2.28933668
82Absent forearm bone (HP:0003953)2.27700389
83Aplasia involving forearm bones (HP:0009822)2.27700389
84Reduced antithrombin III activity (HP:0001976)2.26795969
85Atresia of the external auditory canal (HP:0000413)2.26645607
86Sloping forehead (HP:0000340)2.21977633
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18649312
88Abnormal protein N-linked glycosylation (HP:0012347)2.17301939
89Abnormal protein glycosylation (HP:0012346)2.17301939
90Abnormal glycosylation (HP:0012345)2.17301939
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17301939
92Abnormal lung lobation (HP:0002101)2.17021732
93Cleft eyelid (HP:0000625)2.15681943
94Increased serum pyruvate (HP:0003542)2.14466655
95Abnormality of B cell number (HP:0010975)2.14304838
96Abnormal trabecular bone morphology (HP:0100671)2.13199803
97Thrombocytosis (HP:0001894)2.12930586
98Abnormality of glycolysis (HP:0004366)2.11825701
99Type I transferrin isoform profile (HP:0003642)2.11333336
100Abnormality of the duodenum (HP:0002246)2.10229408
101Impulsivity (HP:0100710)2.09884216
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09255053
103Slender long bone (HP:0003100)2.08673415
104Increased serum lactate (HP:0002151)2.08591246
105Lymphoma (HP:0002665)2.06552643
106Abnormality of the carotid arteries (HP:0005344)2.06112845
107Progressive microcephaly (HP:0000253)2.04519829
108Duplicated collecting system (HP:0000081)2.02809038
109Combined immunodeficiency (HP:0005387)2.01386853
110Hyperglycinemia (HP:0002154)2.00968126
111Supernumerary spleens (HP:0009799)2.00641823
112Severe combined immunodeficiency (HP:0004430)1.98872242
113Secondary amenorrhea (HP:0000869)1.97998436
114Lethargy (HP:0001254)1.97333802
115Premature ovarian failure (HP:0008209)1.95789124
116Ectopic kidney (HP:0000086)1.95252980
117Squamous cell carcinoma (HP:0002860)1.94254396
118Progressive muscle weakness (HP:0003323)1.92325612
119Increased nuchal translucency (HP:0010880)1.90878673
120IgM deficiency (HP:0002850)1.90552516
121Acute lymphatic leukemia (HP:0006721)1.89661052
122Neoplasm of striated muscle (HP:0009728)1.89398065
123Emotional lability (HP:0000712)1.88300188
124Cafe-au-lait spot (HP:0000957)1.87697917
125Hypoplasia of the radius (HP:0002984)1.85927354
126Neoplasm of the colon (HP:0100273)1.85770774
127Poor head control (HP:0002421)1.85052650
128Prominent nose (HP:0000448)1.83584779
129Missing ribs (HP:0000921)1.83101381
130Short thumb (HP:0009778)1.81241020
131Megaloblastic anemia (HP:0001889)1.81030519
132Hepatocellular necrosis (HP:0001404)1.79892134
133Asplenia (HP:0001746)1.79543345
134Gout (HP:0001997)1.79061460
135Short middle phalanx of the 5th finger (HP:0004220)1.78579811
136Clubbing of toes (HP:0100760)1.77916121
137Nephroblastoma (Wilms tumor) (HP:0002667)1.77850011
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77065977
139Abnormality of the renal collecting system (HP:0004742)1.76585858
140Glossoptosis (HP:0000162)1.76349879
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.75507216
142Microvesicular hepatic steatosis (HP:0001414)1.75499426
143Methylmalonic aciduria (HP:0012120)1.75422665
144Optic disc pallor (HP:0000543)1.75121134
145Abnormality of abdominal situs (HP:0011620)1.75048988
146Abdominal situs inversus (HP:0003363)1.75048988
147Abnormality of DNA repair (HP:0003254)1.74366214
148High pitched voice (HP:0001620)1.73443783
149Neutropenia (HP:0001875)1.72266278
150IgG deficiency (HP:0004315)1.71893620
151Dysphonia (HP:0001618)1.65744847
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65633298
153Abnormality of alanine metabolism (HP:0010916)1.65633298
154Hyperalaninemia (HP:0003348)1.65633298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.82074214
2VRK24.66171310
3WEE14.58387523
4BUB14.41136916
5EIF2AK13.15632966
6NEK22.79265996
7NME22.74888005
8SRPK12.58628237
9STK162.52095178
10ACVR1B2.42335126
11VRK12.40629815
12TLK12.39493800
13TTK2.25533038
14NEK12.16865891
15PLK42.08157281
16TESK22.03586475
17BRSK22.00956780
18PLK11.98912759
19DYRK31.93082655
20CDK71.85409077
21EIF2AK31.83753298
22ATR1.74439612
23AURKB1.71921880
24SCYL21.71783731
25PASK1.71689514
26RPS6KA41.66957294
27TSSK61.65410361
28MKNK11.53898220
29RPS6KB21.53292276
30CCNB11.52053976
31TAF11.47840400
32SMG11.45880540
33BRSK11.44672370
34CHEK21.43894817
35AURKA1.42618486
36CDK41.40785684
37MAP3K101.39190809
38MAP3K81.29831858
39EEF2K1.23375109
40MKNK21.22263775
41ARAF1.18858405
42CHEK11.13903233
43CDK81.10952635
44PLK31.09559478
45PAK41.07752989
46STK101.06589228
47STK41.02495401
48TGFBR11.00823914
49KDR1.00721955
50NUAK11.00544765
51PIM20.97665805
52FLT30.88978947
53ERN10.85836261
54ATM0.84302038
55CDK120.83258580
56LRRK20.82509207
57MAP3K110.81325240
58PIM10.79300146
59* CDK20.79063775
60NME10.78268383
61CSNK2A20.74300849
62MAP4K10.73949858
63CSNK1G30.73089633
64BRAF0.72824783
65CSNK2A10.72375497
66CDK190.68174907
67MAPKAPK30.67622836
68ZAK0.67244449
69KIT0.65819811
70TESK10.65381786
71PAK10.60554076
72PKN20.59036581
73EIF2AK20.58081541
74PDK20.57921103
75MAPKAPK50.55519332
76RPS6KA50.55189783
77* CDK10.55182280
78DAPK30.54430231
79CDK140.54127755
80CDK60.52759093
81DYRK20.49702724
82BCKDK0.49376510
83GRK60.49076048
84PRKCI0.48612069
85DAPK10.47186261
86BTK0.44998243
87MELK0.44262373
88ILK0.42545562
89PBK0.42027741
90ALK0.40501423
91CSNK1G10.40212264
92CLK10.39978143
93LIMK10.38533953
94MAP2K30.38423552
95EPHA20.37675152
96CSNK1G20.37077627
97AKT20.36376447
98TEC0.34974476
99CDK30.34837531
100BRD40.34501497
101CSNK1A1L0.33858620
102ABL20.33581241
103PRKDC0.31246300
104RAF10.30358837
105MAP2K20.29538312
106CDK90.28671497
107CSNK1E0.26635697
108CDK11A0.25227261
109MAP3K130.23651890
110MATK0.23414777
111ZAP700.23376837
112YES10.21693939
113TAOK20.20982647
114SYK0.20491788
115MST40.18795380
116MAPK110.18622886
117CDK150.16829822
118LYN0.16764136
119MAPK140.16156539
120CSF1R0.16010610
121CDK180.14701967
122AKT10.14517301

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.88073783
2Mismatch repair_Homo sapiens_hsa034304.81148834
3Ribosome_Homo sapiens_hsa030104.26127152
4Spliceosome_Homo sapiens_hsa030403.43493606
5Base excision repair_Homo sapiens_hsa034103.31715883
6Homologous recombination_Homo sapiens_hsa034403.30241090
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24025177
8Proteasome_Homo sapiens_hsa030503.12603369
9RNA polymerase_Homo sapiens_hsa030203.09309023
10Nucleotide excision repair_Homo sapiens_hsa034203.09008119
11RNA transport_Homo sapiens_hsa030132.84893539
12Cell cycle_Homo sapiens_hsa041102.71016062
13One carbon pool by folate_Homo sapiens_hsa006702.68770611
14* Pyrimidine metabolism_Homo sapiens_hsa002402.63096807
15Fanconi anemia pathway_Homo sapiens_hsa034602.32399199
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19702097
17Non-homologous end-joining_Homo sapiens_hsa034502.06226994
18RNA degradation_Homo sapiens_hsa030181.95787968
19Basal transcription factors_Homo sapiens_hsa030221.69845533
20mRNA surveillance pathway_Homo sapiens_hsa030151.53934124
21p53 signaling pathway_Homo sapiens_hsa041151.49974352
22Purine metabolism_Homo sapiens_hsa002301.39716239
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39202076
24Systemic lupus erythematosus_Homo sapiens_hsa053221.26140854
25Pyruvate metabolism_Homo sapiens_hsa006201.03886838
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02496049
27Epstein-Barr virus infection_Homo sapiens_hsa051691.01899298
28Protein export_Homo sapiens_hsa030601.01691481
29Folate biosynthesis_Homo sapiens_hsa007900.98677056
30Fatty acid elongation_Homo sapiens_hsa000620.98667921
31Sulfur relay system_Homo sapiens_hsa041220.92231309
32Cardiac muscle contraction_Homo sapiens_hsa042600.91859763
33Huntingtons disease_Homo sapiens_hsa050160.90573941
34Oocyte meiosis_Homo sapiens_hsa041140.89010214
35Parkinsons disease_Homo sapiens_hsa050120.88392920
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.88150820
37Herpes simplex infection_Homo sapiens_hsa051680.86322057
38Pentose phosphate pathway_Homo sapiens_hsa000300.81284064
39Viral carcinogenesis_Homo sapiens_hsa052030.80088683
40Antigen processing and presentation_Homo sapiens_hsa046120.76810781
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74880304
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74852564
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73966532
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.73048064
45Biosynthesis of amino acids_Homo sapiens_hsa012300.69965592
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.69200907
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65504758
48Asthma_Homo sapiens_hsa053100.64879209
49Oxidative phosphorylation_Homo sapiens_hsa001900.63906812
50HTLV-I infection_Homo sapiens_hsa051660.63765050
51Selenocompound metabolism_Homo sapiens_hsa004500.61366287
52Thyroid cancer_Homo sapiens_hsa052160.60303197
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59804031
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57808554
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57054535
56N-Glycan biosynthesis_Homo sapiens_hsa005100.54119964
57Primary immunodeficiency_Homo sapiens_hsa053400.53459405
58Propanoate metabolism_Homo sapiens_hsa006400.52782937
59Alcoholism_Homo sapiens_hsa050340.52563161
60Glutathione metabolism_Homo sapiens_hsa004800.52325196
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46755177
62Small cell lung cancer_Homo sapiens_hsa052220.44372315
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40398037
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40328730
65Carbon metabolism_Homo sapiens_hsa012000.39357483
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38622914
67Legionellosis_Homo sapiens_hsa051340.37361340
68MicroRNAs in cancer_Homo sapiens_hsa052060.36879849
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36403967
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36170355
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35449573
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35007042
73Colorectal cancer_Homo sapiens_hsa052100.34547316
74Peroxisome_Homo sapiens_hsa041460.34143284
75Fatty acid metabolism_Homo sapiens_hsa012120.33649896
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33414691
77Apoptosis_Homo sapiens_hsa042100.33217348
78Bladder cancer_Homo sapiens_hsa052190.30384344
79Hepatitis B_Homo sapiens_hsa051610.30230007
80Alzheimers disease_Homo sapiens_hsa050100.28384434
81Measles_Homo sapiens_hsa051620.25423033
82* Metabolic pathways_Homo sapiens_hsa011000.24636502
83Phenylalanine metabolism_Homo sapiens_hsa003600.23606717
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21751700
85Autoimmune thyroid disease_Homo sapiens_hsa053200.21708912
86Shigellosis_Homo sapiens_hsa051310.21404761
87Allograft rejection_Homo sapiens_hsa053300.20349598
88TGF-beta signaling pathway_Homo sapiens_hsa043500.20275536
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18399745
90Tyrosine metabolism_Homo sapiens_hsa003500.18270880
91Vitamin B6 metabolism_Homo sapiens_hsa007500.17829475
92Hematopoietic cell lineage_Homo sapiens_hsa046400.17242473
93Chronic myeloid leukemia_Homo sapiens_hsa052200.16810238
94Fructose and mannose metabolism_Homo sapiens_hsa000510.16296158
95Galactose metabolism_Homo sapiens_hsa000520.16278236
96Acute myeloid leukemia_Homo sapiens_hsa052210.15555920
97Basal cell carcinoma_Homo sapiens_hsa052170.15358926
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13996379
99Notch signaling pathway_Homo sapiens_hsa043300.12274844
100Pathways in cancer_Homo sapiens_hsa052000.12010018
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11402088
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10923473
103Hippo signaling pathway_Homo sapiens_hsa043900.09345846
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09211585
105Renin-angiotensin system_Homo sapiens_hsa046140.08905641
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.08595385
107Sulfur metabolism_Homo sapiens_hsa009200.07917808
108HIF-1 signaling pathway_Homo sapiens_hsa040660.07589780
109Fatty acid degradation_Homo sapiens_hsa000710.07394700
110Type I diabetes mellitus_Homo sapiens_hsa049400.06920631
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06891910
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06454256
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.06274105
114Non-small cell lung cancer_Homo sapiens_hsa052230.05848805
115Influenza A_Homo sapiens_hsa051640.05146190
116Arginine and proline metabolism_Homo sapiens_hsa003300.03306340
117Butanoate metabolism_Homo sapiens_hsa006500.02567722
118Viral myocarditis_Homo sapiens_hsa054160.01732323
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.00936027
120Graft-versus-host disease_Homo sapiens_hsa053320.00798079
121Phototransduction_Homo sapiens_hsa047440.00246466
122Regulation of autophagy_Homo sapiens_hsa041400.00225540
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.00031352
124Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0124042
125Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0071593
126Wnt signaling pathway_Homo sapiens_hsa04310-0.0035134
127Prostate cancer_Homo sapiens_hsa05215-0.0007480

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