ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	6.86233862
2	retinal rod cell development (GO:0046548)	6.50450092
3	response to pheromone (GO:0019236)	4.99419910
4	somite rostral/caudal axis specification (GO:0032525)	4.95936796
5	ER overload response (GO:0006983)	4.83960556
6	positive regulation of SMAD protein import into nucleus (GO:0060391)	4.61388230
7	histone mRNA catabolic process (GO:0071044)	4.41493270
8	melanin biosynthetic process (GO:0042438)	4.27316189
9	sperm motility (GO:0030317)	4.25391770
10	cranial suture morphogenesis (GO:0060363)	4.24416342
11	aggressive behavior (GO:0002118)	4.20587912
12	platelet dense granule organization (GO:0060155)	4.19228060
13	proline transport (GO:0015824)	4.01493242
14	regulation of microtubule-based movement (GO:0060632)	3.88021575
15	ketone body metabolic process (GO:1902224)	3.84139843
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.78204899
17	melanin metabolic process (GO:0006582)	3.71816207
18	negative regulation of cytokine production involved in immune response (GO:0002719)	3.67993774
19	negative regulation of receptor activity (GO:2000272)	3.66124448
20	regulation of macrophage cytokine production (GO:0010935)	3.65502870
21	glycine transport (GO:0015816)	3.64889917
22	regulation of centriole replication (GO:0046599)	3.64055859
23	seminiferous tubule development (GO:0072520)	3.59048065
24	positive regulation of collagen biosynthetic process (GO:0032967)	3.58506437
25	protein prenylation (GO:0018342)	3.56617312
26	prenylation (GO:0097354)	3.56617312
27	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.51997491
28	regulation of SMAD protein import into nucleus (GO:0060390)	3.48914409
29	positive regulation of collagen metabolic process (GO:0010714)	3.41246392
30	definitive hemopoiesis (GO:0060216)	3.40816364
31	secondary metabolite biosynthetic process (GO:0044550)	3.40249912
32	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.37420218
33	histamine secretion (GO:0001821)	3.34489860
34	photoreceptor cell development (GO:0042461)	3.34441262
35	phosphatidylethanolamine metabolic process (GO:0046337)	3.32775719
36	proteasome assembly (GO:0043248)	3.31785659
37	pyrimidine dimer repair (GO:0006290)	3.30616999
38	cullin deneddylation (GO:0010388)	3.29526703
39	eye photoreceptor cell development (GO:0042462)	3.26289046
40	single strand break repair (GO:0000012)	3.23922300
41	relaxation of smooth muscle (GO:0044557)	3.22047267
42	alanine transport (GO:0032328)	3.21440262
43	centriole replication (GO:0007099)	3.19826687
44	positive regulation of multicellular organismal metabolic process (GO:0044253)	3.18186763
45	establishment of protein localization to Golgi (GO:0072600)	3.17905374
46	serotonin receptor signaling pathway (GO:0007210)	3.17612266
47	GPI anchor metabolic process (GO:0006505)	3.14671423
48	regulation of activation of Janus kinase activity (GO:0010533)	3.12180826
49	blood vessel maturation (GO:0001955)	3.08722461
50	eosinophil chemotaxis (GO:0048245)	3.08426347
51	cellular ketone body metabolic process (GO:0046950)	3.07708718
52	gland morphogenesis (GO:0022612)	3.06205471
53	negative regulation of production of molecular mediator of immune response (GO:0002701)	3.05691258
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05474630
55	NADH dehydrogenase complex assembly (GO:0010257)	3.05474630
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05474630
57	protein targeting to Golgi (GO:0000042)	3.03788873
58	protein polyglutamylation (GO:0018095)	3.03501463
59	developmental pigmentation (GO:0048066)	3.02956640
60	microtubule depolymerization (GO:0007019)	3.02133992
61	otic vesicle formation (GO:0030916)	2.97869574
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96020921
63	xenobiotic catabolic process (GO:0042178)	2.90531914
64	negative regulation of neurological system process (GO:0031645)	2.90353098
65	protein complex biogenesis (GO:0070271)	2.88401340
66	response to laminar fluid shear stress (GO:0034616)	2.85688849
67	short-term memory (GO:0007614)	2.84683563
68	protein K11-linked deubiquitination (GO:0035871)	2.83930821
69	regulation of collagen biosynthetic process (GO:0032965)	2.77666822
70	eosinophil migration (GO:0072677)	2.77084481
71	protein deneddylation (GO:0000338)	2.76078642
72	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.74948011
73	negative regulation by host of viral transcription (GO:0043922)	2.74742376
74	RNA destabilization (GO:0050779)	2.73058235
75	NAD biosynthetic process (GO:0009435)	2.72489828
76	positive regulation of mitochondrial fission (GO:0090141)	2.71428861
77	regulation of chronic inflammatory response (GO:0002676)	2.68317530
78	negative regulation of stress fiber assembly (GO:0051497)	2.67457106
79	base-excision repair, AP site formation (GO:0006285)	2.64602286
80	positive regulation of vasculogenesis (GO:2001214)	2.61918462
81	DNA integration (GO:0015074)	2.61873051
82	parental behavior (GO:0060746)	2.61032146
83	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.59800693
84	mismatch repair (GO:0006298)	2.57890960
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57518272
86	histamine transport (GO:0051608)	2.56366360
87	regulation of multicellular organismal metabolic process (GO:0044246)	2.55953169
88	fusion of sperm to egg plasma membrane (GO:0007342)	2.54877369
89	hyperosmotic salinity response (GO:0042538)	2.53193316
90	female mating behavior (GO:0060180)	2.53143530
91	phospholipid homeostasis (GO:0055091)	2.52449325
92	spermatid development (GO:0007286)	2.50995970
93	organelle disassembly (GO:1903008)	2.50174026
94	microtubule severing (GO:0051013)	2.50111423
95	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.49992985
96	protein localization to Golgi apparatus (GO:0034067)	2.49848641
97	leukocyte tethering or rolling (GO:0050901)	2.46475321
98	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.46228535
99	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	2.45844361
100	positive regulation of odontogenesis (GO:0042482)	2.45432616

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.49519748
2	VDR_22108803_ChIP-Seq_LS180_Human	3.27092331
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.03774162
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80951641
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.65843532
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.60469404
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.50200218
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40455316
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.34021178
10	FUS_26573619_Chip-Seq_HEK293_Human	2.33818526
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21412904
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.18783839
13	P300_19829295_ChIP-Seq_ESCs_Human	2.18558669
14	NFE2_27457419_Chip-Seq_LIVER_Mouse	2.11078533
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.06617564
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.06617564
17	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.02616719
18	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.02368784
19	EZH2_27294783_Chip-Seq_NPCs_Mouse	2.01529458
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.97509939
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94634117
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.86751867
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.83581382
24	AR_25329375_ChIP-Seq_VCAP_Human	1.81877888
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76536274
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76076807
27	EWS_26573619_Chip-Seq_HEK293_Human	1.75191564
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.74378413
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.71976262
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69484405
31	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.66883313
32	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.64603639
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.63667380
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.61152074
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59126431
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54933162
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53606778
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.50107316
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49372843
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48652758
41	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.47404088
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46829677
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45927801
44	P300_18555785_Chip-Seq_ESCs_Mouse	1.45785505
45	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.43318075
46	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.40575038
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38134886
48	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.36736939
49	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.35720224
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.35650865
51	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.35188632
52	P53_22387025_ChIP-Seq_ESCs_Mouse	1.34654959
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33501539
54	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.32998690
55	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31953032
56	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.31679384
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31204651
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30730088
59	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.29404857
60	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.29200070
61	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28583238
62	STAT3_23295773_ChIP-Seq_U87_Human	1.26718145
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26545401
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26014979
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26014979
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25905070
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25905070
68	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25443555
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24811819
70	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.24208733
71	TCF4_23295773_ChIP-Seq_U87_Human	1.23810546
72	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.23713124
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22078777
74	PU1_27457419_Chip-Seq_LIVER_Mouse	1.21297194
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20571802
76	ETV1_20927104_ChIP-Seq_GIST48_Human	1.20514805
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20254060
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20128959
79	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.19901266
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.18971693
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18039016
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16881193
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16803967
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15882407
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15580666
86	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.15302230
87	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.15074964
88	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.14779892
89	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14658507
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12773695
91	TCF4_22108803_ChIP-Seq_LS180_Human	1.12283218
92	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.11938646
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11642831
94	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10979332
95	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.10291980
96	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09836468
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09384444
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08644576
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06640312
100	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.06015957

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	5.88970551
2	MP0000372_irregular_coat_pigmentation	5.87558862
3	MP0005075_abnormal_melanosome_morpholog	3.62929005
4	MP0003786_premature_aging	3.08395920
5	MP0005410_abnormal_fertilization	2.94307634
6	MP0003646_muscle_fatigue	2.93316692
7	MP0008057_abnormal_DNA_replication	2.66002142
8	MP0005408_hypopigmentation	2.45468968
9	MP0008058_abnormal_DNA_repair	2.43347225
10	MP0006054_spinal_hemorrhage	2.33033481
11	MP0005670_abnormal_white_adipose	2.13677584
12	MP0005551_abnormal_eye_electrophysiolog	2.09562809
13	MP0003787_abnormal_imprinting	2.07470802
14	MP0003718_maternal_effect	2.02895108
15	MP0002102_abnormal_ear_morphology	1.98966175
16	MP0005367_renal/urinary_system_phenotyp	1.97908684
17	MP0000516_abnormal_urinary_system	1.97908684
18	MP0002295_abnormal_pulmonary_circulatio	1.94283782
19	MP0005379_endocrine/exocrine_gland_phen	1.88486573
20	MP0002095_abnormal_skin_pigmentation	1.76610656
21	MP0002090_abnormal_vision	1.75903352
22	MP0008995_early_reproductive_senescence	1.75086121
23	MP0003136_yellow_coat_color	1.74074911
24	MP0002822_catalepsy	1.66877283
25	MP0001324_abnormal_eye_pigmentation	1.65737977
26	MP0005253_abnormal_eye_physiology	1.62694167
27	MP0003950_abnormal_plasma_membrane	1.56989674
28	MP0002877_abnormal_melanocyte_morpholog	1.55093337
29	MP0002837_dystrophic_cardiac_calcinosis	1.53542115
30	MP0005646_abnormal_pituitary_gland	1.51599645
31	MP0008007_abnormal_cellular_replicative	1.47449041
32	MP0002163_abnormal_gland_morphology	1.47115953
33	MP0008877_abnormal_DNA_methylation	1.45110993
34	MP0004808_abnormal_hematopoietic_stem	1.40458583
35	MP0010386_abnormal_urinary_bladder	1.36279515
36	MP0005171_absent_coat_pigmentation	1.29919866
37	MP0010307_abnormal_tumor_latency	1.26321164
38	MP0002396_abnormal_hematopoietic_system	1.25641342
39	MP0003698_abnormal_male_reproductive	1.24237522
40	MP0001984_abnormal_olfaction	1.23356231
41	MP0005084_abnormal_gallbladder_morpholo	1.22985219
42	MP0003878_abnormal_ear_physiology	1.18548718
43	MP0005377_hearing/vestibular/ear_phenot	1.18548718
44	MP0001188_hyperpigmentation	1.16291368
45	MP0005645_abnormal_hypothalamus_physiol	1.15170878
46	MP0004142_abnormal_muscle_tone	1.14106418
47	MP0002909_abnormal_adrenal_gland	1.14053126
48	MP0004484_altered_response_of	1.13132100
49	MP0001929_abnormal_gametogenesis	1.12563501
50	MP0001177_atelectasis	1.11470146
51	MP0000013_abnormal_adipose_tissue	1.08451014
52	MP0005174_abnormal_tail_pigmentation	1.06632054
53	MP0005360_urolithiasis	1.03740877
54	MP0003186_abnormal_redox_activity	1.01429142
55	MP0001501_abnormal_sleep_pattern	0.99581050
56	MP0004147_increased_porphyrin_level	0.97997175
57	MP0001545_abnormal_hematopoietic_system	0.97595388
58	MP0005397_hematopoietic_system_phenotyp	0.97595388
59	MP0004885_abnormal_endolymph	0.94254648
60	MP0001666_abnormal_nutrient_absorption	0.87468661
61	MP0000371_diluted_coat_color	0.87227522
62	MP0002127_abnormal_cardiovascular_syste	0.85487926
63	MP0003121_genomic_imprinting	0.81412822
64	MP0009697_abnormal_copulation	0.78482613
65	MP0008260_abnormal_autophagy	0.74171937
66	MP0000427_abnormal_hair_cycle	0.70803309
67	MP0002210_abnormal_sex_determination	0.69217725
68	MP0006072_abnormal_retinal_apoptosis	0.68770187
69	MP0004084_abnormal_cardiac_muscle	0.68543880
70	MP0004134_abnormal_chest_morphology	0.68277461
71	MP0004036_abnormal_muscle_relaxation	0.67471950
72	MP0002234_abnormal_pharynx_morphology	0.67326922
73	MP0005248_abnormal_Harderian_gland	0.67238871
74	MP0000653_abnormal_sex_gland	0.65809698
75	MP0002736_abnormal_nociception_after	0.65514239
76	MP0008873_increased_physiological_sensi	0.65205785
77	MP0010094_abnormal_chromosome_stability	0.64636370
78	MP0000613_abnormal_salivary_gland	0.64213592
79	MP0002229_neurodegeneration	0.62935863
80	MP0002638_abnormal_pupillary_reflex	0.62647815
81	MP0004043_abnormal_pH_regulation	0.62382161
82	MP0001905_abnormal_dopamine_level	0.61963961
83	MP0002233_abnormal_nose_morphology	0.60925888
84	MP0001145_abnormal_male_reproductive	0.60440216
85	MP0003693_abnormal_embryo_hatching	0.60356303
86	MP0001486_abnormal_startle_reflex	0.60153583
87	MP0005266_abnormal_metabolism	0.59933463
88	MP0002971_abnormal_brown_adipose	0.59270093
89	MP0006035_abnormal_mitochondrial_morpho	0.59005124
90	MP0002161_abnormal_fertility/fecundity	0.58965878
91	MP0002693_abnormal_pancreas_physiology	0.58667415
92	MP0000647_abnormal_sebaceous_gland	0.58197720
93	MP0000689_abnormal_spleen_morphology	0.58063234
94	MP0000751_myopathy	0.57690952
95	MP0001968_abnormal_touch/_nociception	0.56715969
96	MP0005085_abnormal_gallbladder_physiolo	0.56354022
97	MP0002653_abnormal_ependyma_morphology	0.55410691
98	MP0001915_intracranial_hemorrhage	0.55180071
99	MP0004233_abnormal_muscle_weight	0.54732872
100	MP0000358_abnormal_cell_content/	0.54557687

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.27689149
2	Intestinal atresia (HP:0011100)	4.66455238
3	Volvulus (HP:0002580)	4.57560949
4	Decreased central vision (HP:0007663)	4.41570697
5	Right ventricular cardiomyopathy (HP:0011663)	4.16377707
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.87868899
7	Pancreatic cysts (HP:0001737)	3.77053300
8	Renal cortical cysts (HP:0000803)	3.60553476
9	Attenuation of retinal blood vessels (HP:0007843)	3.60366982
10	True hermaphroditism (HP:0010459)	3.30088668
11	Pancreatic fibrosis (HP:0100732)	3.25227998
12	Abnormality of the renal cortex (HP:0011035)	3.19671992
13	Bony spicule pigmentary retinopathy (HP:0007737)	3.12872093
14	Decreased muscle mass (HP:0003199)	3.06915807
15	Severe visual impairment (HP:0001141)	3.01812088
16	Chronic hepatic failure (HP:0100626)	2.99708367
17	Medial flaring of the eyebrow (HP:0010747)	2.98978721
18	Congenital primary aphakia (HP:0007707)	2.98034548
19	Gait imbalance (HP:0002141)	2.87597314
20	Carpal bone hypoplasia (HP:0001498)	2.83582734
21	Horizontal nystagmus (HP:0000666)	2.72093265
22	Ocular albinism (HP:0001107)	2.71424609
23	Aplasia/Hypoplasia of the macula (HP:0008059)	2.68401632
24	Abnormality of DNA repair (HP:0003254)	2.64878089
25	Nephrogenic diabetes insipidus (HP:0009806)	2.63079579
26	Congenital malformation of the right heart (HP:0011723)	2.61930495
27	Double outlet right ventricle (HP:0001719)	2.61930495
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.59291488
29	Iris hypopigmentation (HP:0007730)	2.54936732
30	Hypoalphalipoproteinemia (HP:0003233)	2.50465160
31	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.49549307
32	J-shaped sella turcica (HP:0002680)	2.46142128
33	Amblyopia (HP:0000646)	2.41954165
34	Facial diplegia (HP:0001349)	2.40165661
35	Astigmatism (HP:0000483)	2.39644863
36	Gastrointestinal atresia (HP:0002589)	2.39202546
37	Abnormality of the pulmonary veins (HP:0011718)	2.36751894
38	Anencephaly (HP:0002323)	2.34684221
39	Autoimmune thrombocytopenia (HP:0001973)	2.33353824
40	Abnormality of renal resorption (HP:0011038)	2.32653663
41	Ectropion (HP:0000656)	2.31514065
42	Reduced antithrombin III activity (HP:0001976)	2.22803325
43	Abnormal umbilical cord blood vessels (HP:0011403)	2.21448465
44	Single umbilical artery (HP:0001195)	2.21448465
45	Abnormality of the fetal cardiovascular system (HP:0010948)	2.21448465
46	Pancreatic islet-cell hyperplasia (HP:0004510)	2.19447619
47	Nephronophthisis (HP:0000090)	2.18295644
48	Bifid uvula (HP:0000193)	2.16716549
49	Poor coordination (HP:0002370)	2.15826471
50	Coxa valga (HP:0002673)	2.15122216
51	Constricted visual fields (HP:0001133)	2.13745962
52	Hepatocellular necrosis (HP:0001404)	2.13421646
53	Fatigue (HP:0012378)	2.12511212
54	Autoimmune hemolytic anemia (HP:0001890)	2.09106359
55	Poikiloderma (HP:0001029)	2.08696776
56	Diastasis recti (HP:0001540)	2.08640419
57	Lipid accumulation in hepatocytes (HP:0006561)	2.08054467
58	Tetraparesis (HP:0002273)	2.06784964
59	Freckling (HP:0001480)	2.06650830
60	Mitochondrial inheritance (HP:0001427)	2.05579644
61	Progressive inability to walk (HP:0002505)	2.03994405
62	Genital tract atresia (HP:0001827)	2.01021402
63	Metaphyseal dysplasia (HP:0100255)	1.96601953
64	Vaginal atresia (HP:0000148)	1.96522220
65	Asthma (HP:0002099)	1.96029692
66	Abnormality of midbrain morphology (HP:0002418)	1.96010215
67	Molar tooth sign on MRI (HP:0002419)	1.96010215
68	Thyroiditis (HP:0100646)	1.95024897
69	Abnormality of dental color (HP:0011073)	1.92907169
70	Congenital hepatic fibrosis (HP:0002612)	1.92530751
71	Abnormality of macular pigmentation (HP:0008002)	1.91802220
72	Hepatic necrosis (HP:0002605)	1.90115996
73	Cystic liver disease (HP:0006706)	1.89873130
74	Abnormality of the renal medulla (HP:0100957)	1.89772442
75	Acute lymphatic leukemia (HP:0006721)	1.87885984
76	Stomatitis (HP:0010280)	1.87878689
77	Renal Fanconi syndrome (HP:0001994)	1.87777135
78	Anomalous pulmonary venous return (HP:0010772)	1.87571840
79	Gonadal dysgenesis (HP:0000133)	1.87370402
80	Complete atrioventricular canal defect (HP:0001674)	1.85639237
81	Aqueductal stenosis (HP:0002410)	1.84807377
82	Cutaneous melanoma (HP:0012056)	1.83184287
83	Photophobia (HP:0000613)	1.81957756
84	3-Methylglutaconic aciduria (HP:0003535)	1.81313184
85	Methylmalonic acidemia (HP:0002912)	1.80714046
86	Abolished electroretinogram (ERG) (HP:0000550)	1.78574608
87	Optic disc pallor (HP:0000543)	1.76874600
88	Small epiphyses (HP:0010585)	1.75812779
89	Increased CSF lactate (HP:0002490)	1.75275563
90	Oligodactyly (hands) (HP:0001180)	1.75131849
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74548340
92	Rib fusion (HP:0000902)	1.74521312
93	Prominent metopic ridge (HP:0005487)	1.72839381
94	Delayed puberty (HP:0000823)	1.72658462
95	Broad alveolar ridges (HP:0000187)	1.71839488
96	Abnormality of endocrine pancreas physiology (HP:0012093)	1.71048332
97	Abnormality of the pancreatic islet cells (HP:0006476)	1.71048332
98	Microvesicular hepatic steatosis (HP:0001414)	1.70905774
99	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.68039882
100	Oligohydramnios (HP:0001562)	1.67474564

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	6.04352530
2	FRK	4.39476916
3	TRIM28	3.94177260
4	FLT3	3.74342239
5	PLK4	3.64552102
6	TAOK3	3.30063449
7	SIK3	3.06806339
8	MAP4K2	2.80999572
9	KIT	2.63163703
10	MAP3K3	2.37566011
11	EIF2AK3	2.28673877
12	TAF1	2.04835336
13	NEK2	2.02163985
14	CDK19	1.86513219
15	TXK	1.73408357
16	VRK2	1.53801693
17	TAOK2	1.47583929
18	PAK3	1.45035383
19	WNK3	1.43068927
20	PIK3CG	1.30320501
21	PINK1	1.27597651
22	BMPR1B	1.25728647
23	SCYL2	1.25134066
24	PBK	1.23955563
25	STK16	1.19111339
26	MAP3K4	1.11442899
27	INSRR	1.06377409
28	MKNK2	1.03762685
29	BCR	1.03587984
30	MKNK1	1.01826866
31	NUAK1	1.00348809
32	GRK1	0.99427153
33	DAPK1	0.97027670
34	KSR1	0.91604258
35	VRK1	0.91437348
36	PLK2	0.90340457
37	ADRBK2	0.87632730
38	MAP2K7	0.82735306
39	TGFBR1	0.79447447
40	MATK	0.73819134
41	EIF2AK1	0.73768306
42	CSNK1G2	0.73589970
43	MARK3	0.73079644
44	CSNK1G3	0.71943255
45	CSF1R	0.71560995
46	BUB1	0.70011765
47	AKT3	0.66558716
48	PDK2	0.66387713
49	LATS1	0.64688816
50	MAPKAPK5	0.64172440
51	ERBB3	0.63837532
52	TNK2	0.63126257
53	CSNK1A1L	0.62888944
54	IKBKE	0.61987469
55	EIF2AK2	0.61563899
56	DYRK1A	0.60474244
57	PRKCQ	0.60139294
58	CAMK1D	0.56518071
59	MAPK13	0.56032675
60	RPS6KB1	0.53931934
61	DYRK2	0.51308661
62	PRKACB	0.50660603
63	MAPKAPK3	0.50608999
64	CDC7	0.49110712
65	CCNB1	0.48326191
66	CAMK1G	0.46766369
67	WNK4	0.46645992
68	CSNK1G1	0.45935005
69	CLK1	0.45354315
70	ACVR1B	0.41129655
71	RPS6KA5	0.41103056
72	CSNK2A1	0.40595079
73	NEK6	0.39444626
74	PTK2B	0.37294093
75	CSNK1A1	0.36707637
76	MAP3K5	0.36421594
77	PRKG1	0.34248232
78	IRAK3	0.33833572
79	PRKCH	0.32587877
80	CSNK2A2	0.31190261
81	PRKACA	0.30032697
82	CHUK	0.29857790
83	PLK3	0.29728660
84	FGFR2	0.29561085
85	IKBKB	0.29414650
86	CAMK1	0.28277012
87	MAPK10	0.27559816
88	DAPK2	0.26905577
89	UHMK1	0.26020884
90	RPS6KA4	0.25873873
91	ABL1	0.25600023
92	MAPK3	0.24273987
93	MAP3K2	0.24266592
94	TEC	0.23680871
95	MAP3K11	0.23436947
96	MYLK	0.23242150
97	MAPK1	0.22976890
98	PRKCB	0.22959146
99	CSNK1D	0.22928544
100	ATM	0.22195872

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.61451653
2	Protein export_Homo sapiens_hsa03060	2.97242814
3	RNA polymerase_Homo sapiens_hsa03020	2.81077434
4	Homologous recombination_Homo sapiens_hsa03440	2.43715137
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.43543070
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.41060461
7	Basal transcription factors_Homo sapiens_hsa03022	2.39406194
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.23082680
9	Rheumatoid arthritis_Homo sapiens_hsa05323	2.16329796
10	Collecting duct acid secretion_Homo sapiens_hsa04966	2.11995800
11	Butanoate metabolism_Homo sapiens_hsa00650	2.11421552
12	Proteasome_Homo sapiens_hsa03050	2.10175349
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.09284155
14	RNA degradation_Homo sapiens_hsa03018	1.96303610
15	RNA transport_Homo sapiens_hsa03013	1.93308948
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.81542647
17	Glutathione metabolism_Homo sapiens_hsa00480	1.80029353
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71392446
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.60406793
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54813575
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.51583522
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.50147813
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.45919831
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.40267259
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.37734538
26	Taste transduction_Homo sapiens_hsa04742	1.33957616
27	Parkinsons disease_Homo sapiens_hsa05012	1.32475065
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.26008286
29	Phototransduction_Homo sapiens_hsa04744	1.25657750
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25395520
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24416490
32	Peroxisome_Homo sapiens_hsa04146	1.24268251
33	Purine metabolism_Homo sapiens_hsa00230	1.22022953
34	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.16622276
35	Propanoate metabolism_Homo sapiens_hsa00640	1.16410354
36	Folate biosynthesis_Homo sapiens_hsa00790	1.15232909
37	Olfactory transduction_Homo sapiens_hsa04740	1.12902280
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.11109223
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.06225455
40	Malaria_Homo sapiens_hsa05144	0.99011725
41	Huntingtons disease_Homo sapiens_hsa05016	0.98275372
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96986518
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96661715
44	Regulation of autophagy_Homo sapiens_hsa04140	0.94158633
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.91306393
46	ABC transporters_Homo sapiens_hsa02010	0.89144467
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88899170
48	Retinol metabolism_Homo sapiens_hsa00830	0.86368486
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84571507
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.83017289
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82630109
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.82392282
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81905983
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75162876
55	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.74706573
56	Serotonergic synapse_Homo sapiens_hsa04726	0.72439442
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71651020
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70290732
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69243828
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68706240
61	Sulfur relay system_Homo sapiens_hsa04122	0.67557329
62	p53 signaling pathway_Homo sapiens_hsa04115	0.67415593
63	Primary immunodeficiency_Homo sapiens_hsa05340	0.66080290
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.65643805
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.65530933
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.64958125
67	Circadian entrainment_Homo sapiens_hsa04713	0.64643432
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64622195
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62668389
70	Metabolic pathways_Homo sapiens_hsa01100	0.62292235
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.61086567
72	Mismatch repair_Homo sapiens_hsa03430	0.61009402
73	Leishmaniasis_Homo sapiens_hsa05140	0.60728368
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59208516
75	Measles_Homo sapiens_hsa05162	0.58777097
76	Legionellosis_Homo sapiens_hsa05134	0.58576611
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56754355
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.56475809
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55184010
80	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.54995074
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.51937894
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.51909185
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51130102
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.50962677
85	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.49758254
86	Sulfur metabolism_Homo sapiens_hsa00920	0.49291338
87	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49269861
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.49205446
89	Colorectal cancer_Homo sapiens_hsa05210	0.48120806
90	Lysosome_Homo sapiens_hsa04142	0.46966646
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.44598837
92	Nicotine addiction_Homo sapiens_hsa05033	0.42554181
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.41194150
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40301779
95	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39870091
96	Herpes simplex infection_Homo sapiens_hsa05168	0.39318802
97	Fatty acid degradation_Homo sapiens_hsa00071	0.38494993
98	Salivary secretion_Homo sapiens_hsa04970	0.38225821
99	Alzheimers disease_Homo sapiens_hsa05010	0.37593805
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35785215

DUTP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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