DUTP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1imidazole-containing compound metabolic process (GO:0052803)8.20774616
2replication fork processing (GO:0031297)8.05957139
3maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.40657783
4DNA double-strand break processing (GO:0000729)6.03557576
5centriole replication (GO:0007099)5.63936502
6DNA replication-dependent nucleosome organization (GO:0034723)5.61860093
7DNA replication-dependent nucleosome assembly (GO:0006335)5.61860093
8translesion synthesis (GO:0019985)5.17509665
9negative regulation of DNA recombination (GO:0045910)5.16639365
10chromatin remodeling at centromere (GO:0031055)4.94712707
11centrosome duplication (GO:0051298)4.92163979
12CENP-A containing nucleosome assembly (GO:0034080)4.81532811
13mitotic sister chromatid segregation (GO:0000070)4.68808263
14meiotic chromosome segregation (GO:0045132)4.66411280
15telomere maintenance via semi-conservative replication (GO:0032201)4.63525191
16DNA topological change (GO:0006265)4.63436671
17negative regulation of DNA-dependent DNA replication (GO:2000104)4.51858081
18protein localization to kinetochore (GO:0034501)4.49342746
19regulation of double-strand break repair via homologous recombination (GO:0010569)4.49234698
20DNA strand renaturation (GO:0000733)4.48725084
21sister chromatid segregation (GO:0000819)4.45320324
22kinetochore organization (GO:0051383)4.42680048
23mitotic sister chromatid cohesion (GO:0007064)4.41958554
24DNA strand elongation involved in DNA replication (GO:0006271)4.38053166
25regulation of DNA endoreduplication (GO:0032875)4.36354339
26regulation of T cell tolerance induction (GO:0002664)4.36282014
27resolution of meiotic recombination intermediates (GO:0000712)4.33856222
28postreplication repair (GO:0006301)4.32868735
29DNA strand elongation (GO:0022616)4.29557328
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.27794154
31metaphase plate congression (GO:0051310)4.27015972
32intra-S DNA damage checkpoint (GO:0031573)4.21690412
33DNA catabolic process, exonucleolytic (GO:0000738)4.17522609
34histone exchange (GO:0043486)4.16517103
35centriole assembly (GO:0098534)4.10448931
36mitotic metaphase plate congression (GO:0007080)4.06639558
37somatic hypermutation of immunoglobulin genes (GO:0016446)4.00201858
38somatic diversification of immune receptors via somatic mutation (GO:0002566)4.00201858
39telomere maintenance via recombination (GO:0000722)3.98352974
40DNA ligation (GO:0006266)3.98323445
41mitotic recombination (GO:0006312)3.98197628
42double-strand break repair via nonhomologous end joining (GO:0006303)3.95738253
43non-recombinational repair (GO:0000726)3.95738253
44positive regulation of mast cell degranulation (GO:0043306)3.83738590
45positive regulation of mast cell activation involved in immune response (GO:0033008)3.83738590
46protein localization to chromosome, centromeric region (GO:0071459)3.83160269
47regulation of T cell cytokine production (GO:0002724)3.78055640
48DNA replication-independent nucleosome assembly (GO:0006336)3.71502068
49DNA replication-independent nucleosome organization (GO:0034724)3.71502068
50spindle checkpoint (GO:0031577)3.66508764
51T cell apoptotic process (GO:0070231)3.66293658
52mitotic chromosome condensation (GO:0007076)3.63203478
53recombinational repair (GO:0000725)3.63148999
54double-strand break repair via homologous recombination (GO:0000724)3.62940614
55attachment of spindle microtubules to kinetochore (GO:0008608)3.62812225
56mitotic G2/M transition checkpoint (GO:0044818)3.62806387
57establishment of chromosome localization (GO:0051303)3.61797702
58endosome to melanosome transport (GO:0035646)3.61266533
59endosome to pigment granule transport (GO:0043485)3.61266533
60kinetochore assembly (GO:0051382)3.59751466
61mitotic nuclear envelope disassembly (GO:0007077)3.53687421
62DNA replication initiation (GO:0006270)3.53383426
63DNA replication checkpoint (GO:0000076)3.52816648
64otic vesicle formation (GO:0030916)3.51946144
65microtubule depolymerization (GO:0007019)3.50983135
66DNA geometric change (GO:0032392)3.48555864
67mismatch repair (GO:0006298)3.48239503
68regulation of centriole replication (GO:0046599)3.47444216
69catecholamine biosynthetic process (GO:0042423)3.45621397
70catechol-containing compound biosynthetic process (GO:0009713)3.45621397
71cellular biogenic amine biosynthetic process (GO:0042401)3.44614637
72regulation of tolerance induction (GO:0002643)3.44398005
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39625447
74DNA duplex unwinding (GO:0032508)3.38354823
75telomere maintenance via telomere lengthening (GO:0010833)3.37089937
76mitotic spindle checkpoint (GO:0071174)3.30632217
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30386768
78synapsis (GO:0007129)3.28443552
79chromosome segregation (GO:0007059)3.27640917
80mitotic G2 DNA damage checkpoint (GO:0007095)3.27013243
81angiotensin maturation (GO:0002003)3.26006652
82amine biosynthetic process (GO:0009309)3.24003624
83centrosome organization (GO:0051297)3.23786384
84nuclear envelope disassembly (GO:0051081)3.23496778
85membrane disassembly (GO:0030397)3.23496778
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23325325
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23325325
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23325325
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.23325325
90negative regulation of sister chromatid segregation (GO:0033046)3.23325325
91telomere maintenance (GO:0000723)3.23207925
92negative regulation of chromosome segregation (GO:0051985)3.20360114
93telomere organization (GO:0032200)3.19570528
94nuclear pore complex assembly (GO:0051292)3.13249475
95mitotic spindle assembly checkpoint (GO:0007094)3.10926698
96regulation of DNA recombination (GO:0000018)3.10756428
97purine nucleobase biosynthetic process (GO:0009113)3.10039816
98regulation of double-strand break repair (GO:2000779)3.09158675
99lymphocyte apoptotic process (GO:0070227)3.08219787
100spindle assembly checkpoint (GO:0071173)3.07514651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.96814291
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.49779157
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.11868370
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.92730181
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.63784146
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14612335
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11988353
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.81880516
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.77597008
10AR_21909140_ChIP-Seq_LNCAP_Human2.56385957
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.29175648
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.15924915
13ELK1_19687146_ChIP-ChIP_HELA_Human2.04858700
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03095201
15E2F7_22180533_ChIP-Seq_HELA_Human11.2786792
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97968889
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78421347
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73975604
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.68957606
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66136220
21IRF1_19129219_ChIP-ChIP_H3396_Human1.65780478
22FOXP3_21729870_ChIP-Seq_TREG_Human1.57774365
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56360195
24ZNF274_21170338_ChIP-Seq_K562_Hela1.53395760
25VDR_23849224_ChIP-Seq_CD4+_Human1.48577003
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45801946
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37122156
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36862759
29FUS_26573619_Chip-Seq_HEK293_Human1.36812446
30VDR_22108803_ChIP-Seq_LS180_Human1.36544998
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33957895
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33750557
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33694450
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30661731
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28453047
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.27483598
37EWS_26573619_Chip-Seq_HEK293_Human1.27145950
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.25537236
39MYC_18940864_ChIP-ChIP_HL60_Human1.23730253
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23135275
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20077891
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20077367
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.17688169
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16997688
45E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14232700
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13281813
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11134237
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10532192
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.09485197
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08839796
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08769365
52ER_23166858_ChIP-Seq_MCF-7_Human1.02712919
53TTF2_22483619_ChIP-Seq_HELA_Human1.02184206
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.01828211
55DCP1A_22483619_ChIP-Seq_HELA_Human1.00572549
56PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99844907
57IGF1R_20145208_ChIP-Seq_DFB_Human0.99636094
58P300_19829295_ChIP-Seq_ESCs_Human0.97443128
59MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94528301
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94094468
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92830959
62E2F1_18555785_Chip-Seq_ESCs_Mouse0.91802551
63SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91139594
64WT1_19549856_ChIP-ChIP_CCG9911_Human0.90826454
65STAT3_18555785_Chip-Seq_ESCs_Mouse0.90466106
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90406961
67GABP_19822575_ChIP-Seq_HepG2_Human0.90365016
68NANOG_16153702_ChIP-ChIP_HESCs_Human0.88188432
69SOX2_16153702_ChIP-ChIP_HESCs_Human0.87520714
70PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87207471
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86835840
72NFE2_27457419_Chip-Seq_LIVER_Mouse0.86681188
73SOX2_18555785_Chip-Seq_ESCs_Mouse0.86373302
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85331469
75P300_18555785_Chip-Seq_ESCs_Mouse0.85296548
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84710615
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84320978
78ZFX_18555785_Chip-Seq_ESCs_Mouse0.83798179
79E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83746647
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82273083
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82252421
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.81219697
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80794497
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80553439
85BCAT_22108803_ChIP-Seq_LS180_Human0.80498764
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80060017
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79207934
88P53_22387025_ChIP-Seq_ESCs_Mouse0.79099422
89NMYC_18555785_Chip-Seq_ESCs_Mouse0.78791056
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78684926
91SMAD1_18555785_Chip-Seq_ESCs_Mouse0.78189907
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.75721766
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.75664771
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74755041
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74489306
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74267979
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73702262
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72258019
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72103755
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.70758038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.70503438
2MP0008058_abnormal_DNA_repair5.05870041
3MP0000372_irregular_coat_pigmentation4.17118913
4MP0008057_abnormal_DNA_replication4.15091905
5MP0003693_abnormal_embryo_hatching3.39738224
6MP0003111_abnormal_nucleus_morphology3.29379656
7MP0003806_abnormal_nucleotide_metabolis3.26207894
8MP0005171_absent_coat_pigmentation3.25845006
9MP0003950_abnormal_plasma_membrane2.98005680
10MP0009697_abnormal_copulation2.92170752
11MP0006292_abnormal_olfactory_placode2.86815255
12MP0001986_abnormal_taste_sensitivity2.74203915
13MP0004957_abnormal_blastocyst_morpholog2.65470356
14MP0003077_abnormal_cell_cycle2.50564875
15MP0005075_abnormal_melanosome_morpholog2.49161900
16MP0003136_yellow_coat_color2.37092824
17MP0005423_abnormal_somatic_nervous2.28097310
18MP0008877_abnormal_DNA_methylation2.27572079
19MP0002735_abnormal_chemical_nociception2.23370941
20MP0008995_early_reproductive_senescence2.13859298
21MP0003718_maternal_effect2.04592643
22MP0003786_premature_aging1.93983336
23MP0008932_abnormal_embryonic_tissue1.76050893
24MP0005408_hypopigmentation1.66305335
25MP0003195_calcinosis1.64332547
26MP0002396_abnormal_hematopoietic_system1.55345610
27MP0004147_increased_porphyrin_level1.52470723
28MP0002938_white_spotting1.47416889
29MP0001293_anophthalmia1.36428921
30MP0001929_abnormal_gametogenesis1.35998908
31MP0005174_abnormal_tail_pigmentation1.33100643
32MP0000569_abnormal_digit_pigmentation1.31992856
33MP0000015_abnormal_ear_pigmentation1.31698019
34MP0002210_abnormal_sex_determination1.30089233
35MP0004381_abnormal_hair_follicle1.21496723
36MP0008789_abnormal_olfactory_epithelium1.20447195
37MP0003943_abnormal_hepatobiliary_system1.18676463
38MP0002233_abnormal_nose_morphology1.17694146
39MP0000371_diluted_coat_color1.09287724
40MP0003121_genomic_imprinting1.06746757
41MP0009115_abnormal_fat_cell1.06653803
42MP0002102_abnormal_ear_morphology1.06458494
43MP0008007_abnormal_cellular_replicative1.05577282
44MP0003880_abnormal_central_pattern1.03811459
45MP0000653_abnormal_sex_gland1.00366212
46MP0002970_abnormal_white_adipose0.99806442
47MP0002095_abnormal_skin_pigmentation0.99128368
48MP0003787_abnormal_imprinting0.98956599
49MP0001145_abnormal_male_reproductive0.98056182
50MP0001324_abnormal_eye_pigmentation0.96694661
51MP0001873_stomach_inflammation0.93299107
52MP0001119_abnormal_female_reproductive0.92970026
53MP0005076_abnormal_cell_differentiation0.91014762
54MP0001697_abnormal_embryo_size0.90701790
55MP0001672_abnormal_embryogenesis/_devel0.88464265
56MP0005380_embryogenesis_phenotype0.88464265
57MP0003698_abnormal_male_reproductive0.85894350
58MP0003123_paternal_imprinting0.85804011
59MP0010307_abnormal_tumor_latency0.85783690
60MP0000516_abnormal_urinary_system0.85133877
61MP0005367_renal/urinary_system_phenotyp0.85133877
62MP0002075_abnormal_coat/hair_pigmentati0.83389782
63MP0009765_abnormal_xenobiotic_induced0.83194826
64MP0002751_abnormal_autonomic_nervous0.81105300
65MP0010030_abnormal_orbit_morphology0.79676013
66MP0005395_other_phenotype0.79538306
67MP0002734_abnormal_mechanical_nocicepti0.79366874
68MP0009703_decreased_birth_body0.79316418
69MP0003984_embryonic_growth_retardation0.76399413
70MP0000350_abnormal_cell_proliferation0.75903082
71MP0006036_abnormal_mitochondrial_physio0.75671563
72MP0000313_abnormal_cell_death0.74561475
73MP0001286_abnormal_eye_development0.74471486
74MP0004145_abnormal_muscle_electrophysio0.74134629
75MP0001730_embryonic_growth_arrest0.73977749
76MP0002088_abnormal_embryonic_growth/wei0.73480018
77MP0003699_abnormal_female_reproductive0.73139533
78MP0005499_abnormal_olfactory_system0.72283768
79MP0005394_taste/olfaction_phenotype0.72283768
80MP0001853_heart_inflammation0.72166572
81MP0009672_abnormal_birth_weight0.72083902
82MP0002080_prenatal_lethality0.68993041
83MP0004197_abnormal_fetal_growth/weight/0.67875485
84MP0006276_abnormal_autonomic_nervous0.67036717
85MP0003890_abnormal_embryonic-extraembry0.66628860
86MP0001764_abnormal_homeostasis0.66558943
87MP0002019_abnormal_tumor_incidence0.66082810
88MP0010352_gastrointestinal_tract_polyps0.65939870
89MP0005266_abnormal_metabolism0.64352098
90MP0001529_abnormal_vocalization0.63477252
91MP0002084_abnormal_developmental_patter0.61991578
92MP0002971_abnormal_brown_adipose0.61770490
93MP0002160_abnormal_reproductive_system0.61476815
94MP0005551_abnormal_eye_electrophysiolog0.61246724
95MP0002928_abnormal_bile_duct0.61168324
96MP0008872_abnormal_physiological_respon0.59531567
97MP0002234_abnormal_pharynx_morphology0.59117906
98MP0005197_abnormal_uvea_morphology0.58173987
99MP0005253_abnormal_eye_physiology0.57980356
100MP0002085_abnormal_embryonic_tissue0.57083419

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.10803062
2Chromsome breakage (HP:0040012)5.41002602
3Abnormality of chromosome stability (HP:0003220)4.41380010
4Aplasia/Hypoplasia of the uvula (HP:0010293)4.29805098
5Meckel diverticulum (HP:0002245)4.14151008
6Papilledema (HP:0001085)4.07387681
7Abnormality of the ileum (HP:0001549)4.04714795
8Abnormality of the preputium (HP:0100587)3.98487591
9Volvulus (HP:0002580)3.98473374
10Birth length less than 3rd percentile (HP:0003561)3.35259335
11Duodenal stenosis (HP:0100867)3.28487312
12Small intestinal stenosis (HP:0012848)3.28487312
13Duplicated collecting system (HP:0000081)3.27111018
14Type 2 muscle fiber atrophy (HP:0003554)3.24490568
15Clubbing of toes (HP:0100760)3.23301558
16Absent septum pellucidum (HP:0001331)3.12724829
17Abnormality of the labia minora (HP:0012880)3.11723463
18Ependymoma (HP:0002888)3.04782973
19Septo-optic dysplasia (HP:0100842)2.91257047
20Ectopic kidney (HP:0000086)2.90717299
21Abnormality of the duodenum (HP:0002246)2.90120938
22Abnormality of the renal collecting system (HP:0004742)2.87705014
23Absent radius (HP:0003974)2.83016129
24Sloping forehead (HP:0000340)2.82363958
25Myelodysplasia (HP:0002863)2.81465930
26Abnormality of the carotid arteries (HP:0005344)2.75559108
27Abnormality of the septum pellucidum (HP:0007375)2.68558550
28Male infertility (HP:0003251)2.68489748
29Absent forearm bone (HP:0003953)2.63241123
30Aplasia involving forearm bones (HP:0009822)2.63241123
31Abnormality of pyrimidine metabolism (HP:0004353)2.60791734
32Muscle fiber atrophy (HP:0100295)2.59056720
33Abnormality of placental membranes (HP:0011409)2.55235888
34Amniotic constriction ring (HP:0009775)2.55235888
35Bone marrow hypocellularity (HP:0005528)2.50035866
36Abnormal lung lobation (HP:0002101)2.47139048
37Progressive inability to walk (HP:0002505)2.45665582
38Long clavicles (HP:0000890)2.40077479
39High pitched voice (HP:0001620)2.39837609
40Premature graying of hair (HP:0002216)2.26754553
41Abnormality of the pons (HP:0007361)2.25044670
42Abnormality of the astrocytes (HP:0100707)2.24954815
43Astrocytoma (HP:0009592)2.24954815
44Popliteal pterygium (HP:0009756)2.23464186
45Glioma (HP:0009733)2.22025060
46Chronic hepatic failure (HP:0100626)2.20514057
47Asplenia (HP:0001746)2.19223184
48Nephroblastoma (Wilms tumor) (HP:0002667)2.18285277
49Failure to thrive in infancy (HP:0001531)2.18000701
50Abnormality of the neuromuscular junction (HP:0003398)2.10678729
51Fatigable weakness (HP:0003473)2.10678729
52Abnormality of methionine metabolism (HP:0010901)2.09180468
53Triphalangeal thumb (HP:0001199)2.07051379
54Oligohydramnios (HP:0001562)2.06712770
55Intestinal atresia (HP:0011100)2.06108267
56Embryonal renal neoplasm (HP:0011794)2.05795297
57Small hand (HP:0200055)2.00023958
58Astigmatism (HP:0000483)1.99758546
59Hypoplasia of the pons (HP:0012110)1.97711805
60Aplasia/Hypoplasia of the spleen (HP:0010451)1.95533221
61Absent thumb (HP:0009777)1.95490897
62Colon cancer (HP:0003003)1.92862291
63Neurodegeneration (HP:0002180)1.91108955
64Cystic hygroma (HP:0000476)1.89657360
65Nephrogenic diabetes insipidus (HP:0009806)1.89479356
66Patellar aplasia (HP:0006443)1.89177255
67Cafe-au-lait spot (HP:0000957)1.83563480
68White forelock (HP:0002211)1.81106691
69Recurrent corneal erosions (HP:0000495)1.80450909
70Patchy hypopigmentation of hair (HP:0011365)1.77316376
71Bifid tongue (HP:0010297)1.76910788
72Pancreatic islet-cell hyperplasia (HP:0004510)1.74408581
73Rhabdomyosarcoma (HP:0002859)1.74375442
74Abnormality of midbrain morphology (HP:0002418)1.74040992
75Molar tooth sign on MRI (HP:0002419)1.74040992
76Cellular immunodeficiency (HP:0005374)1.74029195
77Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73137753
78Neoplasm of the oral cavity (HP:0100649)1.72219754
79Abnormalities of placenta or umbilical cord (HP:0001194)1.71271006
80Irregular epiphyses (HP:0010582)1.71060758
81Abnormality of DNA repair (HP:0003254)1.70062658
82Aplasia/Hypoplasia of the patella (HP:0006498)1.67182541
83Abnormality of cochlea (HP:0000375)1.66582370
84Abnormality of B cell number (HP:0010975)1.65513339
85Hypobetalipoproteinemia (HP:0003563)1.64154449
86Type I transferrin isoform profile (HP:0003642)1.62841001
87Neoplasm of the adrenal cortex (HP:0100641)1.61866831
88Arteriovenous malformation (HP:0100026)1.61455055
89Increased nuchal translucency (HP:0010880)1.61411404
90Tracheoesophageal fistula (HP:0002575)1.61073058
91Albinism (HP:0001022)1.59423675
92Congenital primary aphakia (HP:0007707)1.59394921
93Hypoplasia of the fovea (HP:0007750)1.57095739
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.57095739
95Orthostatic hypotension (HP:0001278)1.56918866
96Ureteral duplication (HP:0000073)1.56892561
97Impulsivity (HP:0100710)1.56272760
98Abnormality of lateral ventricle (HP:0030047)1.55560169
99Hypopigmentation of the fundus (HP:0007894)1.54546574
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.54427109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM286.33913913
2MUSK5.14497854
3WEE13.79255008
4PDK23.61889798
5PNCK3.10993347
6BUB12.73654390
7TNIK2.71886440
8CDC72.61463148
9EIF2AK12.55250989
10PLK42.49243110
11EIF2AK32.35117468
12BRSK22.31388832
13TTK2.23209427
14MKNK22.16253917
15NEK12.07995987
16FRK2.01137819
17PLK31.85092749
18ZAK1.80402045
19NUAK11.78745460
20PBK1.77709508
21MKNK11.73881633
22ERBB41.72610002
23ATR1.63368414
24PLK11.54909771
25ACVR1B1.49368700
26TSSK61.46664463
27BMPR1B1.43406440
28MARK31.40931207
29NEK21.34664802
30VRK11.31732731
31MST41.30786703
32EIF2AK21.29414432
33BRSK11.21752020
34SRPK11.18844517
35WNK31.15152640
36CHEK21.09270887
37FER1.04639071
38BRD41.02431669
39AURKB0.96688994
40SIK30.95834251
41ERBB30.92895530
42MAP4K20.87547359
43STK40.85483310
44CAMK1G0.83776479
45CCNB10.81508105
46ATM0.78378161
47NME10.77906466
48PLK20.75836557
49PRKD30.75532507
50MAPK130.74872292
51CHEK10.71684111
52PIM10.69242021
53STK30.68946330
54VRK20.67909703
55TGFBR10.62403157
56STK100.59987213
57MELK0.56274725
58STK390.55556318
59CDK70.53204963
60PKN10.50252533
61GRK70.50002697
62AKT30.44439208
63CDK10.42435813
64CDK60.41402063
65GRK10.40718302
66CSNK2A10.40659766
67BMPR20.39314370
68CDK20.38934256
69CLK10.38627445
70DAPK10.34553138
71PRKCH0.32584287
72CDK40.30964286
73INSRR0.29555801
74EGFR0.28718241
75TGFBR20.28330823
76PRKD20.27187646
77GRK60.27037324
78PRKDC0.25562542
79GSK3A0.25446558
80NLK0.24882660
81TLK10.24331972
82CSNK1D0.23797962
83MAP3K40.21181324
84STK160.20862772
85CDK30.20434179
86CAMK1D0.19076704
87TAF10.17647391
88PRKCE0.16287876
89PRKCI0.15377414
90LATS10.15341699
91PAK60.15331822
92DYRK30.14735172
93FLT30.14070830
94CSNK2A20.13966335
95PRKACB0.13135067
96MAPK140.12020652
97MATK0.11707965
98FGFR10.10965652
99GSK3B0.10317280
100CSNK1G10.10265445

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.65282262
2DNA replication_Homo sapiens_hsa030304.40869042
3Non-homologous end-joining_Homo sapiens_hsa034504.40719115
4Fanconi anemia pathway_Homo sapiens_hsa034604.19622280
5Homologous recombination_Homo sapiens_hsa034404.13228478
6Histidine metabolism_Homo sapiens_hsa003402.96923246
7Cell cycle_Homo sapiens_hsa041102.77260003
8Proteasome_Homo sapiens_hsa030502.51359528
9Base excision repair_Homo sapiens_hsa034102.39520756
10Nucleotide excision repair_Homo sapiens_hsa034202.35886162
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35450704
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05348549
13One carbon pool by folate_Homo sapiens_hsa006701.89513423
14Renin-angiotensin system_Homo sapiens_hsa046141.87055104
15RNA transport_Homo sapiens_hsa030131.87015759
16Oocyte meiosis_Homo sapiens_hsa041141.74359447
17RNA degradation_Homo sapiens_hsa030181.60171197
18Propanoate metabolism_Homo sapiens_hsa006401.49260438
19Basal transcription factors_Homo sapiens_hsa030221.48228462
20Asthma_Homo sapiens_hsa053101.46533464
21Protein export_Homo sapiens_hsa030601.44187382
22Spliceosome_Homo sapiens_hsa030401.43085083
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.42679255
24p53 signaling pathway_Homo sapiens_hsa041151.41684945
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32113861
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30739809
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30439465
28Pyrimidine metabolism_Homo sapiens_hsa002401.30256922
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26422813
30RNA polymerase_Homo sapiens_hsa030201.26026911
31Caffeine metabolism_Homo sapiens_hsa002321.24412764
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21745720
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21415066
34Selenocompound metabolism_Homo sapiens_hsa004501.09810967
35mRNA surveillance pathway_Homo sapiens_hsa030151.08709031
36Butanoate metabolism_Homo sapiens_hsa006501.05927085
37Fatty acid elongation_Homo sapiens_hsa000620.91066461
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90226569
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.86734561
40Purine metabolism_Homo sapiens_hsa002300.86308016
41Phototransduction_Homo sapiens_hsa047440.85016519
42Lysine degradation_Homo sapiens_hsa003100.84679118
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84347078
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81063631
45Peroxisome_Homo sapiens_hsa041460.80253945
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78589054
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76878046
48Pyruvate metabolism_Homo sapiens_hsa006200.68602641
49Fatty acid metabolism_Homo sapiens_hsa012120.66970128
50Nitrogen metabolism_Homo sapiens_hsa009100.66032588
51TGF-beta signaling pathway_Homo sapiens_hsa043500.64769271
52Systemic lupus erythematosus_Homo sapiens_hsa053220.63587378
53Glutathione metabolism_Homo sapiens_hsa004800.62961659
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62495937
55Chemical carcinogenesis_Homo sapiens_hsa052040.59034569
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58889219
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58708280
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58433068
59Olfactory transduction_Homo sapiens_hsa047400.58081501
60Fatty acid degradation_Homo sapiens_hsa000710.57990958
61Steroid biosynthesis_Homo sapiens_hsa001000.56199490
62Carbon metabolism_Homo sapiens_hsa012000.56122036
63Biosynthesis of amino acids_Homo sapiens_hsa012300.56050219
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55615384
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.54223074
66Alcoholism_Homo sapiens_hsa050340.53042695
67N-Glycan biosynthesis_Homo sapiens_hsa005100.50436577
68Retinol metabolism_Homo sapiens_hsa008300.48202414
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48132982
70Prostate cancer_Homo sapiens_hsa052150.47443726
71Metabolic pathways_Homo sapiens_hsa011000.44939033
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44357885
73Other glycan degradation_Homo sapiens_hsa005110.42554217
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.42130452
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.41973755
76MicroRNAs in cancer_Homo sapiens_hsa052060.37876383
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33786949
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.33536920
79Tryptophan metabolism_Homo sapiens_hsa003800.32661660
80Huntingtons disease_Homo sapiens_hsa050160.32215538
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31889788
82Starch and sucrose metabolism_Homo sapiens_hsa005000.30953054
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27559085
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25585642
85Colorectal cancer_Homo sapiens_hsa052100.24919177
86Viral carcinogenesis_Homo sapiens_hsa052030.23219717
87Fat digestion and absorption_Homo sapiens_hsa049750.22940524
88Parkinsons disease_Homo sapiens_hsa050120.20827866
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19737608
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19435389
91Linoleic acid metabolism_Homo sapiens_hsa005910.19350972
92Pentose phosphate pathway_Homo sapiens_hsa000300.19141087
93Glycerolipid metabolism_Homo sapiens_hsa005610.15842565
94Hippo signaling pathway_Homo sapiens_hsa043900.15709647
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14929978
96Vitamin digestion and absorption_Homo sapiens_hsa049770.13636996
97Taste transduction_Homo sapiens_hsa047420.12660436
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12516732
99Arachidonic acid metabolism_Homo sapiens_hsa005900.12491299
100Ether lipid metabolism_Homo sapiens_hsa005650.11159511

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