ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of complement activation (GO:0045916)	5.11679657
2	head development (GO:0060322)	4.96345629
3	neuronal action potential propagation (GO:0019227)	4.78127345
4	cullin deneddylation (GO:0010388)	4.73656499
5	DNA integration (GO:0015074)	4.68793448
6	cartilage morphogenesis (GO:0060536)	4.60437707
7	pyrimidine nucleobase catabolic process (GO:0006208)	4.57178756
8	prenylation (GO:0097354)	4.52134061
9	protein prenylation (GO:0018342)	4.52134061
10	negative regulation of protein activation cascade (GO:2000258)	4.50132757
11	presynaptic membrane organization (GO:0097090)	4.38344967
12	presynaptic membrane assembly (GO:0097105)	4.29377198
13	respiratory chain complex IV assembly (GO:0008535)	4.24158343
14	nucleotide transmembrane transport (GO:1901679)	4.07529034
15	protein deneddylation (GO:0000338)	3.96922067
16	negative regulation of humoral immune response (GO:0002921)	3.83717232
17	centriole replication (GO:0007099)	3.77957040
18	cytochrome complex assembly (GO:0017004)	3.77874270
19	retinal metabolic process (GO:0042574)	3.70972353
20	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.69146089
21	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.69146089
22	terpenoid biosynthetic process (GO:0016114)	3.67636681
23	diterpenoid biosynthetic process (GO:0016102)	3.65771389
24	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.65512794
25	intraciliary transport (GO:0042073)	3.64915242
26	mitochondrial fission (GO:0000266)	3.64782535
27	protein targeting to Golgi (GO:0000042)	3.63883593
28	lipopolysaccharide biosynthetic process (GO:0009103)	3.62848953
29	replication fork processing (GO:0031297)	3.57930386
30	myelin assembly (GO:0032288)	3.55626047
31	chaperone-mediated protein complex assembly (GO:0051131)	3.55080836
32	retinal rod cell development (GO:0046548)	3.53824390
33	neural tube formation (GO:0001841)	3.50204446
34	establishment of protein localization to Golgi (GO:0072600)	3.48704220
35	protein K11-linked deubiquitination (GO:0035871)	3.45340024
36	nucleobase catabolic process (GO:0046113)	3.42581354
37	keratinocyte development (GO:0003334)	3.41404740
38	nuclear pore organization (GO:0006999)	3.39868927
39	interleukin-6-mediated signaling pathway (GO:0070102)	3.39686939
40	DNA double-strand break processing (GO:0000729)	3.38502659
41	serotonin metabolic process (GO:0042428)	3.37774187
42	branched-chain amino acid catabolic process (GO:0009083)	3.35003061
43	olfactory bulb development (GO:0021772)	3.33614983
44	ribonucleoprotein complex disassembly (GO:0032988)	3.32605785
45	postsynaptic membrane organization (GO:0001941)	3.31144908
46	succinate metabolic process (GO:0006105)	3.25040994
47	retinal cone cell development (GO:0046549)	3.24872167
48	lipopolysaccharide metabolic process (GO:0008653)	3.24744727
49	nonmotile primary cilium assembly (GO:0035058)	3.23388345
50	primary amino compound metabolic process (GO:1901160)	3.22668069
51	cellular ketone body metabolic process (GO:0046950)	3.21696723
52	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.13608348
53	protein localization to Golgi apparatus (GO:0034067)	3.11146622
54	negative regulation of neurological system process (GO:0031645)	3.11015873
55	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.09350349
56	peptidyl-histidine modification (GO:0018202)	3.08164721
57	blood vessel maturation (GO:0001955)	3.06987427
58	regulation of collateral sprouting (GO:0048670)	3.05957264
59	cornea development in camera-type eye (GO:0061303)	3.05312675
60	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.04599498
61	tyrosine metabolic process (GO:0006570)	3.02695742
62	photoreceptor cell maintenance (GO:0045494)	3.02064687
63	retinal ganglion cell axon guidance (GO:0031290)	2.98027951
64	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.97433512
65	somite development (GO:0061053)	2.97382304
66	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.97078300
67	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.96040013
68	photoreceptor cell development (GO:0042461)	2.95642430
69	regulation of cilium movement (GO:0003352)	2.92871378
70	positive regulation of calcium ion import (GO:0090280)	2.90985536
71	eye photoreceptor cell development (GO:0042462)	2.88254569
72	positive regulation of amino acid transport (GO:0051957)	2.88149529
73	response to folic acid (GO:0051593)	2.87355557
74	lipid particle organization (GO:0034389)	2.87027291
75	T cell migration (GO:0072678)	2.85265923
76	cholesterol biosynthetic process (GO:0006695)	2.83516174
77	glial cell proliferation (GO:0014009)	2.83117900
78	cilium organization (GO:0044782)	2.83008828
79	regulation of development, heterochronic (GO:0040034)	2.82931984
80	ketone body metabolic process (GO:1902224)	2.81679735
81	cilium assembly (GO:0042384)	2.79804846
82	radial glial cell differentiation (GO:0060019)	2.79432588
83	protein-cofactor linkage (GO:0018065)	2.78747214
84	regulation of male gonad development (GO:2000018)	2.74634706
85	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.72656067
86	cilium morphogenesis (GO:0060271)	2.70640120
87	microtubule depolymerization (GO:0007019)	2.70515497
88	nuclear pore complex assembly (GO:0051292)	2.70244181
89	positive regulation of mitochondrial fission (GO:0090141)	2.67729472
90	isoprenoid biosynthetic process (GO:0008299)	2.67369971
91	single strand break repair (GO:0000012)	2.65066351
92	limb bud formation (GO:0060174)	2.64962688
93	sterol biosynthetic process (GO:0016126)	2.62810994
94	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.62067403
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.62067403
96	galactose catabolic process (GO:0019388)	2.61739822
97	embryonic forelimb morphogenesis (GO:0035115)	2.61119902
98	centriole assembly (GO:0098534)	2.58310627
99	mesenchymal cell development (GO:0014031)	2.57229103
100	transepithelial transport (GO:0070633)	2.56142762

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	5.39110816
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13198385
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.03208598
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.01148539
5	ELK1_19687146_ChIP-ChIP_HELA_Human	2.90369357
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.82431309
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76488815
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.74304364
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.58077652
10	FUS_26573619_Chip-Seq_HEK293_Human	2.49921363
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.46843206
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.35704513
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28635508
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27469398
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.21459853
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.19535948
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09920989
18	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.03970444
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.03181915
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.96844293
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96842319
22	P300_19829295_ChIP-Seq_ESCs_Human	1.95896867
23	EWS_26573619_Chip-Seq_HEK293_Human	1.93826981
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79185028
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77700638
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77700638
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76635246
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.76153401
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73980391
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73746177
31	VDR_22108803_ChIP-Seq_LS180_Human	1.71581849
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.69988402
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.64417766
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.64052330
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.63607685
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63060258
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60196662
38	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.54148584
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52664276
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48375862
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48244101
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47716890
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.40694447
44	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.39924206
45	STAT3_23295773_ChIP-Seq_U87_Human	1.38195042
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.37019882
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36529432
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36375190
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35663014
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30941348
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30905396
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28760930
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28426056
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26524933
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26205552
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25871402
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25780096
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25780096
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.25519619
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.24543369
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21125057
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19224679
63	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15815480
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15208701
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12813675
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.12425102
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12425102
68	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10787311
69	TCF4_23295773_ChIP-Seq_U87_Human	1.09589876
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09489409
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08803069
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08711478
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07650839
74	AR_25329375_ChIP-Seq_VCAP_Human	1.06196393
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06066315
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06028373
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05528053
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05069882
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03137156
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02705957
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02309259
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.00668397
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99177278
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98360558
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.97315014
86	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96400287
87	DCP1A_22483619_ChIP-Seq_HELA_Human	0.95231702
88	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94870623
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94407892
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94315712
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93909691
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.93249925
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92138935
94	AR_20517297_ChIP-Seq_VCAP_Human	0.91712918
95	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.91291633
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.88282439
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86775081
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86655115
99	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.85648724
100	SMRT_27268052_Chip-Seq_Bcells_Human	0.84120751

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	5.24857877
2	MP0003880_abnormal_central_pattern	4.81571813
3	MP0002837_dystrophic_cardiac_calcinosis	4.24640435
4	MP0002102_abnormal_ear_morphology	3.25971786
5	MP0005499_abnormal_olfactory_system	3.24748655
6	MP0005394_taste/olfaction_phenotype	3.24748655
7	MP0000579_abnormal_nail_morphology	2.85303116
8	MP0001984_abnormal_olfaction	2.68514264
9	MP0003646_muscle_fatigue	2.49670237
10	MP0000372_irregular_coat_pigmentation	2.31629886
11	MP0006292_abnormal_olfactory_placode	2.31432577
12	MP0001529_abnormal_vocalization	2.28171539
13	MP0000427_abnormal_hair_cycle	2.27169967
14	MP0006276_abnormal_autonomic_nervous	2.19739940
15	MP0008789_abnormal_olfactory_epithelium	2.18711866
16	MP0000647_abnormal_sebaceous_gland	2.15458394
17	MP0002638_abnormal_pupillary_reflex	2.02979155
18	MP0003937_abnormal_limbs/digits/tail_de	2.01601527
19	MP0005253_abnormal_eye_physiology	1.97955481
20	MP0003890_abnormal_embryonic-extraembry	1.97851624
21	MP0002233_abnormal_nose_morphology	1.95381171
22	MP0009697_abnormal_copulation	1.93528685
23	MP0003136_yellow_coat_color	1.82004750
24	MP0003221_abnormal_cardiomyocyte_apopto	1.80656722
25	MP0006072_abnormal_retinal_apoptosis	1.78226650
26	MP0000751_myopathy	1.76396196
27	MP0000049_abnormal_middle_ear	1.64491285
28	MP0005551_abnormal_eye_electrophysiolog	1.60807346
29	MP0005075_abnormal_melanosome_morpholog	1.57488398
30	MP0002234_abnormal_pharynx_morphology	1.57246894
31	MP0003755_abnormal_palate_morphology	1.45259415
32	MP0002095_abnormal_skin_pigmentation	1.43585199
33	MP0002282_abnormal_trachea_morphology	1.42005841
34	MP0003195_calcinosis	1.40437037
35	MP0005085_abnormal_gallbladder_physiolo	1.39846821
36	MP0002249_abnormal_larynx_morphology	1.34571767
37	MP0002098_abnormal_vibrissa_morphology	1.34052764
38	MP0004145_abnormal_muscle_electrophysio	1.29146945
39	MP0002751_abnormal_autonomic_nervous	1.28103800
40	MP0001324_abnormal_eye_pigmentation	1.25199008
41	MP0005391_vision/eye_phenotype	1.25093108
42	MP0000778_abnormal_nervous_system	1.17117123
43	MP0003186_abnormal_redox_activity	1.16667722
44	MP0008007_abnormal_cellular_replicative	1.15725045
45	MP0002295_abnormal_pulmonary_circulatio	1.14795342
46	MP0005360_urolithiasis	1.12450103
47	MP0001293_anophthalmia	1.10589152
48	MP0009046_muscle_twitch	1.08124661
49	MP0001486_abnormal_startle_reflex	1.06812017
50	MP0003122_maternal_imprinting	1.06804162
51	MP0005171_absent_coat_pigmentation	1.05771563
52	MP0005365_abnormal_bile_salt	1.04181230
53	MP0001177_atelectasis	1.03083701
54	MP0010307_abnormal_tumor_latency	0.94072802
55	MP0001849_ear_inflammation	0.93061001
56	MP0003045_fibrosis	0.91839165
57	MP0001764_abnormal_homeostasis	0.90782150
58	MP0002109_abnormal_limb_morphology	0.90129703
59	MP0002822_catalepsy	0.90050305
60	MP0003938_abnormal_ear_development	0.88556371
61	MP0008058_abnormal_DNA_repair	0.86252845
62	MP0003567_abnormal_fetal_cardiomyocyte	0.85253614
63	MP0005187_abnormal_penis_morphology	0.84219534
64	MP0003942_abnormal_urinary_system	0.83976406
65	MP0001502_abnormal_circadian_rhythm	0.83217989
66	MP0002752_abnormal_somatic_nervous	0.80359332
67	MP0005386_behavior/neurological_phenoty	0.79636492
68	MP0004924_abnormal_behavior	0.79636492
69	MP0004270_analgesia	0.79594101
70	MP0002272_abnormal_nervous_system	0.78898903
71	MP0002111_abnormal_tail_morphology	0.78500262
72	MP0009745_abnormal_behavioral_response	0.75965941
73	MP0003935_abnormal_craniofacial_develop	0.74954076
74	MP0001286_abnormal_eye_development	0.72775287
75	MP0002882_abnormal_neuron_morphology	0.71695549
76	MP0003698_abnormal_male_reproductive	0.71478796
77	MP0002092_abnormal_eye_morphology	0.69848772
78	MP0003137_abnormal_impulse_conducting	0.68722487
79	MP0004215_abnormal_myocardial_fiber	0.67898197
80	MP0000371_diluted_coat_color	0.67305812
81	MP0002938_white_spotting	0.66650490
82	MP0000377_abnormal_hair_follicle	0.66461935
83	MP0001963_abnormal_hearing_physiology	0.66331300
84	MP0002557_abnormal_social/conspecific_i	0.66083363
85	MP0001970_abnormal_pain_threshold	0.64620914
86	MP0002177_abnormal_outer_ear	0.62752015
87	MP0003385_abnormal_body_wall	0.61274315
88	MP0002063_abnormal_learning/memory/cond	0.60160957
89	MP0004142_abnormal_muscle_tone	0.60075968
90	MP0005195_abnormal_posterior_eye	0.59680530
91	MP0001661_extended_life_span	0.58248633
92	MP0000749_muscle_degeneration	0.56906458
93	MP0002152_abnormal_brain_morphology	0.55604284
94	MP0001485_abnormal_pinna_reflex	0.55545591
95	MP0001968_abnormal_touch/_nociception	0.54673824
96	MP0002084_abnormal_developmental_patter	0.54135356
97	MP0001243_abnormal_dermal_layer	0.53699771
98	MP0003861_abnormal_nervous_system	0.53022668
99	MP0004043_abnormal_pH_regulation	0.52144900
100	MP0002736_abnormal_nociception_after	0.51531675

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.59151010
2	Lipid accumulation in hepatocytes (HP:0006561)	4.36259485
3	Congenital primary aphakia (HP:0007707)	4.31463435
4	Gait imbalance (HP:0002141)	4.27455216
5	Nephrogenic diabetes insipidus (HP:0009806)	4.02024494
6	Medial flaring of the eyebrow (HP:0010747)	4.01774867
7	Panhypogammaglobulinemia (HP:0003139)	3.79542958
8	Tubulointerstitial nephritis (HP:0001970)	3.70943302
9	Amyotrophic lateral sclerosis (HP:0007354)	3.48528877
10	Vaginal atresia (HP:0000148)	3.48388987
11	Genital tract atresia (HP:0001827)	3.35482539
12	Decreased testicular size (HP:0008734)	3.29057457
13	Sensorimotor neuropathy (HP:0007141)	3.24696513
14	Follicular hyperkeratosis (HP:0007502)	3.15356427
15	Poor coordination (HP:0002370)	3.08773813
16	Axonal loss (HP:0003447)	3.07583411
17	Renal Fanconi syndrome (HP:0001994)	3.05776675
18	True hermaphroditism (HP:0010459)	3.01808174
19	Broad foot (HP:0001769)	2.90542882
20	Adactyly (HP:0009776)	2.89114580
21	Abolished electroretinogram (ERG) (HP:0000550)	2.87187359
22	Pancreatic cysts (HP:0001737)	2.77737074
23	Hepatocellular necrosis (HP:0001404)	2.76172969
24	Respiratory difficulties (HP:0002880)	2.71154274
25	Thyroid-stimulating hormone excess (HP:0002925)	2.69840330
26	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.59161199
27	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.52384184
28	Broad alveolar ridges (HP:0000187)	2.50517058
29	Pancreatic fibrosis (HP:0100732)	2.50481143
30	Chronic mucocutaneous candidiasis (HP:0002728)	2.50299169
31	Recurrent cutaneous fungal infections (HP:0011370)	2.50299169
32	Ketoacidosis (HP:0001993)	2.49228811
33	Hepatic necrosis (HP:0002605)	2.46309108
34	Increased intramyocellular lipid droplets (HP:0012240)	2.45412364
35	Exertional dyspnea (HP:0002875)	2.44125283
36	Intestinal atresia (HP:0011100)	2.41574798
37	Progressive cerebellar ataxia (HP:0002073)	2.41181589
38	Partial agenesis of the corpus callosum (HP:0001338)	2.40708814
39	Peripheral hypomyelination (HP:0007182)	2.36196407
40	Febrile seizures (HP:0002373)	2.36113422
41	Aplasia/Hypoplasia of the lens (HP:0008063)	2.35518764
42	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.35387374
43	Progressive inability to walk (HP:0002505)	2.35305884
44	Conjunctival telangiectasia (HP:0000524)	2.35099550
45	Molar tooth sign on MRI (HP:0002419)	2.34387830
46	Abnormality of midbrain morphology (HP:0002418)	2.34387830
47	Sclerocornea (HP:0000647)	2.22772109
48	Abnormality of DNA repair (HP:0003254)	2.19047125
49	Increased muscle lipid content (HP:0009058)	2.18846812
50	Septo-optic dysplasia (HP:0100842)	2.16752511
51	Pendular nystagmus (HP:0012043)	2.16299231
52	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.12592168
53	Spontaneous hematomas (HP:0007420)	2.11917445
54	Severe global developmental delay (HP:0011344)	2.11742070
55	Split foot (HP:0001839)	2.09577804
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05779743
57	Renal cortical cysts (HP:0000803)	2.05755482
58	Widely spaced teeth (HP:0000687)	2.04777719
59	Abnormality of renal resorption (HP:0011038)	2.03562809
60	Abnormality of the antihelix (HP:0009738)	2.02583428
61	Abnormality of dental color (HP:0011073)	2.02443418
62	Mitochondrial inheritance (HP:0001427)	2.02387829
63	Vacuolated lymphocytes (HP:0001922)	2.00330328
64	Hip dysplasia (HP:0001385)	1.98588980
65	Vitreoretinal degeneration (HP:0000655)	1.98555296
66	Drooling (HP:0002307)	1.98032724
67	Abnormality of chromosome stability (HP:0003220)	1.95894762
68	Status epilepticus (HP:0002133)	1.95767888
69	Delayed CNS myelination (HP:0002188)	1.95499126
70	CNS demyelination (HP:0007305)	1.91640645
71	Flat capital femoral epiphysis (HP:0003370)	1.90946489
72	Genetic anticipation (HP:0003743)	1.88130920
73	Short foot (HP:0001773)	1.86850855
74	Congenital hepatic fibrosis (HP:0002612)	1.86331813
75	Hyperphosphaturia (HP:0003109)	1.85957420
76	Pigmentary retinal degeneration (HP:0001146)	1.85671016
77	Postaxial hand polydactyly (HP:0001162)	1.84752785
78	Excessive salivation (HP:0003781)	1.84312973
79	Severe combined immunodeficiency (HP:0004430)	1.84005141
80	Micropenis (HP:0000054)	1.82600226
81	Respiratory failure (HP:0002878)	1.82138231
82	Astigmatism (HP:0000483)	1.81725479
83	Volvulus (HP:0002580)	1.80452678
84	Generalized tonic-clonic seizures (HP:0002069)	1.79548691
85	Hyperinsulinemic hypoglycemia (HP:0000825)	1.79406207
86	Increased CSF lactate (HP:0002490)	1.78856108
87	Chronic hepatic failure (HP:0100626)	1.78786923
88	Renal hypoplasia (HP:0000089)	1.76709328
89	Hyperglycinemia (HP:0002154)	1.76008336
90	Colon cancer (HP:0003003)	1.73918563
91	Specific learning disability (HP:0001328)	1.73287515
92	Entropion (HP:0000621)	1.72555376
93	Hypoglycemic seizures (HP:0002173)	1.71311990
94	Absent speech (HP:0001344)	1.71215273
95	Abnormality of the renal medulla (HP:0100957)	1.71177626
96	Ectropion (HP:0000656)	1.67813202
97	Decreased central vision (HP:0007663)	1.64522640
98	Nephronophthisis (HP:0000090)	1.63782073
99	Woolly hair (HP:0002224)	1.63013080
100	Ketosis (HP:0001946)	1.62757226

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	5.35323783
2	TESK2	4.93612079
3	MAP4K2	4.02564533
4	TRIM28	3.39502819
5	STK38L	3.05412636
6	CASK	2.99798646
7	EIF2AK1	2.91574795
8	RPS6KA4	2.55100094
9	MAP3K10	2.33721599
10	WNK3	2.27931585
11	EPHA4	2.25405669
12	DYRK3	2.19301571
13	STK39	2.08912715
14	BCR	1.96509508
15	MKNK2	1.79368879
16	EIF2AK3	1.77419900
17	FRK	1.75866016
18	OXSR1	1.70390578
19	BMPR2	1.66198174
20	IRAK1	1.52683689
21	MKNK1	1.51231679
22	MARK1	1.50528885
23	BUB1	1.42354373
24	SRPK1	1.29035889
25	MAPK13	1.19295825
26	NUAK1	1.18587625
27	MAPKAPK3	1.08904788
28	DYRK2	1.04873353
29	TNIK	1.04699027
30	INSRR	1.02999112
31	DMPK	1.02400589
32	TESK1	1.01644612
33	NTRK2	0.97371917
34	MST4	0.97288016
35	FER	0.96463810
36	MAP2K3	0.95242510
37	UHMK1	0.90961459
38	BCKDK	0.90398835
39	RPS6KA5	0.90068648
40	NLK	0.89980083
41	PDK2	0.89494674
42	YES1	0.86427809
43	CSNK1G1	0.86155246
44	PLK2	0.86014774
45	CSNK1A1L	0.79740241
46	MAP2K4	0.78652575
47	DYRK1A	0.78542417
48	MAP3K4	0.75916662
49	IRAK2	0.75099949
50	VRK1	0.74831170
51	TAOK1	0.67280047
52	STK11	0.66064321
53	CSNK1G3	0.63556148
54	ZAK	0.59409836
55	LIMK1	0.55190185
56	TNK2	0.55069671
57	CAMKK2	0.54985135
58	CDK5	0.53830417
59	CDK3	0.53614339
60	CSNK1G2	0.53406198
61	FGR	0.53120042
62	PRKCE	0.52632805
63	FES	0.52445962
64	MAP2K7	0.50912682
65	STK16	0.50136109
66	TEC	0.49993997
67	PIM2	0.49950060
68	ZAP70	0.49675060
69	PASK	0.49241336
70	ERBB3	0.46778942
71	SIK3	0.45769137
72	TSSK6	0.44937956
73	STK3	0.44645293
74	EIF2AK2	0.42785591
75	RAF1	0.40621733
76	MET	0.39599716
77	IRAK4	0.39248202
78	MINK1	0.37322952
79	CAMK4	0.36091467
80	ITK	0.34755587
81	DYRK1B	0.33718306
82	ACVR1B	0.32751786
83	ATM	0.31357117
84	ERBB4	0.30559052
85	MAP3K7	0.30479476
86	PTK2B	0.30392390
87	AKT3	0.28727141
88	GRK1	0.28611183
89	TXK	0.28150714
90	CSNK1A1	0.27247012
91	CSK	0.26063522
92	PAK3	0.23818479
93	PRKACA	0.23035007
94	MAPK11	0.21979024
95	EPHB2	0.21922649
96	BRSK2	0.21628170
97	JAK3	0.21357564
98	WNK4	0.20189369
99	MAP2K6	0.20031649
100	PRKCQ	0.19580333

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.73067216
2	Butanoate metabolism_Homo sapiens_hsa00650	4.44705464
3	Protein export_Homo sapiens_hsa03060	3.74760944
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.82584471
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.66276912
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.62923616
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.53386259
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.50554880
9	Propanoate metabolism_Homo sapiens_hsa00640	2.46147853
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.24297176
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.20449548
12	beta-Alanine metabolism_Homo sapiens_hsa00410	2.19708541
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08846406
14	Nicotine addiction_Homo sapiens_hsa05033	2.06306762
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.85237319
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.73736798
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.70712491
18	Peroxisome_Homo sapiens_hsa04146	1.67894008
19	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.46705181
20	Retinol metabolism_Homo sapiens_hsa00830	1.43905444
21	Olfactory transduction_Homo sapiens_hsa04740	1.29343649
22	RNA polymerase_Homo sapiens_hsa03020	1.27191095
23	Circadian rhythm_Homo sapiens_hsa04710	1.25967018
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19988852
25	Basal transcription factors_Homo sapiens_hsa03022	1.18310538
26	Homologous recombination_Homo sapiens_hsa03440	1.16682816
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.16646822
28	GABAergic synapse_Homo sapiens_hsa04727	1.14018402
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.13455901
30	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.11727987
31	mRNA surveillance pathway_Homo sapiens_hsa03015	1.08079521
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.07835703
33	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.07744097
34	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.06979488
35	Fatty acid metabolism_Homo sapiens_hsa01212	1.06780975
36	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.05488694
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.01890715
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.00068267
39	Fatty acid degradation_Homo sapiens_hsa00071	0.97303171
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.96203901
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95656391
42	Spliceosome_Homo sapiens_hsa03040	0.94712207
43	Basal cell carcinoma_Homo sapiens_hsa05217	0.93681847
44	RNA degradation_Homo sapiens_hsa03018	0.91341490
45	Parkinsons disease_Homo sapiens_hsa05012	0.89411911
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85268261
47	Regulation of autophagy_Homo sapiens_hsa04140	0.85185091
48	Phototransduction_Homo sapiens_hsa04744	0.84543285
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82616534
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80413708
51	RNA transport_Homo sapiens_hsa03013	0.76926176
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69905050
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68732052
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67464128
55	Other glycan degradation_Homo sapiens_hsa00511	0.65886675
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65728351
57	Taste transduction_Homo sapiens_hsa04742	0.63570985
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.62983014
59	Huntingtons disease_Homo sapiens_hsa05016	0.61848815
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61543843
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.59915519
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56972701
63	Hippo signaling pathway_Homo sapiens_hsa04390	0.53546095
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.52300672
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.50795444
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50002388
67	Morphine addiction_Homo sapiens_hsa05032	0.49821113
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.49624351
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49594931
70	Glutathione metabolism_Homo sapiens_hsa00480	0.49478201
71	Metabolic pathways_Homo sapiens_hsa01100	0.46500723
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45883789
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45582131
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.45518998
75	Alcoholism_Homo sapiens_hsa05034	0.44117830
76	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.43544926
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41902851
78	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.41268463
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40702976
80	ABC transporters_Homo sapiens_hsa02010	0.36770632
81	Glucagon signaling pathway_Homo sapiens_hsa04922	0.34856220
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32928199
83	Linoleic acid metabolism_Homo sapiens_hsa00591	0.32619462
84	Fatty acid elongation_Homo sapiens_hsa00062	0.32603291
85	Ras signaling pathway_Homo sapiens_hsa04014	0.30730570
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29322060
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.27504791
88	Lysine degradation_Homo sapiens_hsa00310	0.23581840
89	Histidine metabolism_Homo sapiens_hsa00340	0.23561962
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23444309
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.23289884
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23265020
93	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.22348714
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.21830630
95	Alzheimers disease_Homo sapiens_hsa05010	0.21632584
96	Amphetamine addiction_Homo sapiens_hsa05031	0.21054058
97	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.20980130
98	Carbon metabolism_Homo sapiens_hsa01200	0.20711911
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.20103955
100	Axon guidance_Homo sapiens_hsa04360	0.18551813

DUTP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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