DUTP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)5.11679657
2head development (GO:0060322)4.96345629
3neuronal action potential propagation (GO:0019227)4.78127345
4cullin deneddylation (GO:0010388)4.73656499
5DNA integration (GO:0015074)4.68793448
6cartilage morphogenesis (GO:0060536)4.60437707
7pyrimidine nucleobase catabolic process (GO:0006208)4.57178756
8prenylation (GO:0097354)4.52134061
9protein prenylation (GO:0018342)4.52134061
10negative regulation of protein activation cascade (GO:2000258)4.50132757
11presynaptic membrane organization (GO:0097090)4.38344967
12presynaptic membrane assembly (GO:0097105)4.29377198
13respiratory chain complex IV assembly (GO:0008535)4.24158343
14nucleotide transmembrane transport (GO:1901679)4.07529034
15protein deneddylation (GO:0000338)3.96922067
16negative regulation of humoral immune response (GO:0002921)3.83717232
17centriole replication (GO:0007099)3.77957040
18cytochrome complex assembly (GO:0017004)3.77874270
19retinal metabolic process (GO:0042574)3.70972353
20mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.69146089
21positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.69146089
22terpenoid biosynthetic process (GO:0016114)3.67636681
23diterpenoid biosynthetic process (GO:0016102)3.65771389
24positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.65512794
25intraciliary transport (GO:0042073)3.64915242
26mitochondrial fission (GO:0000266)3.64782535
27protein targeting to Golgi (GO:0000042)3.63883593
28lipopolysaccharide biosynthetic process (GO:0009103)3.62848953
29replication fork processing (GO:0031297)3.57930386
30myelin assembly (GO:0032288)3.55626047
31chaperone-mediated protein complex assembly (GO:0051131)3.55080836
32retinal rod cell development (GO:0046548)3.53824390
33neural tube formation (GO:0001841)3.50204446
34establishment of protein localization to Golgi (GO:0072600)3.48704220
35protein K11-linked deubiquitination (GO:0035871)3.45340024
36nucleobase catabolic process (GO:0046113)3.42581354
37keratinocyte development (GO:0003334)3.41404740
38nuclear pore organization (GO:0006999)3.39868927
39interleukin-6-mediated signaling pathway (GO:0070102)3.39686939
40DNA double-strand break processing (GO:0000729)3.38502659
41serotonin metabolic process (GO:0042428)3.37774187
42branched-chain amino acid catabolic process (GO:0009083)3.35003061
43olfactory bulb development (GO:0021772)3.33614983
44ribonucleoprotein complex disassembly (GO:0032988)3.32605785
45postsynaptic membrane organization (GO:0001941)3.31144908
46succinate metabolic process (GO:0006105)3.25040994
47retinal cone cell development (GO:0046549)3.24872167
48lipopolysaccharide metabolic process (GO:0008653)3.24744727
49nonmotile primary cilium assembly (GO:0035058)3.23388345
50primary amino compound metabolic process (GO:1901160)3.22668069
51cellular ketone body metabolic process (GO:0046950)3.21696723
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13608348
53protein localization to Golgi apparatus (GO:0034067)3.11146622
54negative regulation of neurological system process (GO:0031645)3.11015873
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.09350349
56peptidyl-histidine modification (GO:0018202)3.08164721
57blood vessel maturation (GO:0001955)3.06987427
58regulation of collateral sprouting (GO:0048670)3.05957264
59cornea development in camera-type eye (GO:0061303)3.05312675
60negative regulation of calcium ion transport into cytosol (GO:0010523)3.04599498
61tyrosine metabolic process (GO:0006570)3.02695742
62photoreceptor cell maintenance (GO:0045494)3.02064687
63retinal ganglion cell axon guidance (GO:0031290)2.98027951
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97433512
65somite development (GO:0061053)2.97382304
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97078300
67positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96040013
68photoreceptor cell development (GO:0042461)2.95642430
69regulation of cilium movement (GO:0003352)2.92871378
70positive regulation of calcium ion import (GO:0090280)2.90985536
71eye photoreceptor cell development (GO:0042462)2.88254569
72positive regulation of amino acid transport (GO:0051957)2.88149529
73response to folic acid (GO:0051593)2.87355557
74lipid particle organization (GO:0034389)2.87027291
75T cell migration (GO:0072678)2.85265923
76cholesterol biosynthetic process (GO:0006695)2.83516174
77glial cell proliferation (GO:0014009)2.83117900
78cilium organization (GO:0044782)2.83008828
79regulation of development, heterochronic (GO:0040034)2.82931984
80ketone body metabolic process (GO:1902224)2.81679735
81cilium assembly (GO:0042384)2.79804846
82radial glial cell differentiation (GO:0060019)2.79432588
83protein-cofactor linkage (GO:0018065)2.78747214
84regulation of male gonad development (GO:2000018)2.74634706
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72656067
86cilium morphogenesis (GO:0060271)2.70640120
87microtubule depolymerization (GO:0007019)2.70515497
88nuclear pore complex assembly (GO:0051292)2.70244181
89positive regulation of mitochondrial fission (GO:0090141)2.67729472
90isoprenoid biosynthetic process (GO:0008299)2.67369971
91single strand break repair (GO:0000012)2.65066351
92limb bud formation (GO:0060174)2.64962688
93sterol biosynthetic process (GO:0016126)2.62810994
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62067403
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62067403
96galactose catabolic process (GO:0019388)2.61739822
97embryonic forelimb morphogenesis (GO:0035115)2.61119902
98centriole assembly (GO:0098534)2.58310627
99mesenchymal cell development (GO:0014031)2.57229103
100transepithelial transport (GO:0070633)2.56142762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.39110816
2ZNF274_21170338_ChIP-Seq_K562_Hela3.13198385
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.03208598
4GBX2_23144817_ChIP-Seq_PC3_Human3.01148539
5ELK1_19687146_ChIP-ChIP_HELA_Human2.90369357
6TAF15_26573619_Chip-Seq_HEK293_Human2.82431309
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.76488815
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74304364
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58077652
10FUS_26573619_Chip-Seq_HEK293_Human2.49921363
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.46843206
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35704513
13IGF1R_20145208_ChIP-Seq_DFB_Human2.28635508
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27469398
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.21459853
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19535948
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09920989
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03970444
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03181915
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96844293
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.96842319
22P300_19829295_ChIP-Seq_ESCs_Human1.95896867
23EWS_26573619_Chip-Seq_HEK293_Human1.93826981
24SMAD4_21799915_ChIP-Seq_A2780_Human1.79185028
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77700638
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77700638
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76635246
28VDR_23849224_ChIP-Seq_CD4+_Human1.76153401
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73980391
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73746177
31VDR_22108803_ChIP-Seq_LS180_Human1.71581849
32EZH2_22144423_ChIP-Seq_EOC_Human1.69988402
33ER_23166858_ChIP-Seq_MCF-7_Human1.64417766
34MYC_18940864_ChIP-ChIP_HL60_Human1.64052330
35BCAT_22108803_ChIP-Seq_LS180_Human1.63607685
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63060258
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60196662
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.54148584
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52664276
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.48375862
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48244101
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47716890
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.40694447
44TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.39924206
45STAT3_23295773_ChIP-Seq_U87_Human1.38195042
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37019882
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.36529432
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36375190
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35663014
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30941348
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.30905396
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28760930
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28426056
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26524933
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26205552
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25871402
57NANOG_19829295_ChIP-Seq_ESCs_Human1.25780096
58SOX2_19829295_ChIP-Seq_ESCs_Human1.25780096
59TCF4_22108803_ChIP-Seq_LS180_Human1.25519619
60MYC_19829295_ChIP-Seq_ESCs_Human1.24543369
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.21125057
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19224679
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15815480
64FOXP3_21729870_ChIP-Seq_TREG_Human1.15208701
65RUNX2_22187159_ChIP-Seq_PCA_Human1.12813675
66CBP_20019798_ChIP-Seq_JUKART_Human1.12425102
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12425102
68HTT_18923047_ChIP-ChIP_STHdh_Human1.10787311
69TCF4_23295773_ChIP-Seq_U87_Human1.09589876
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09489409
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.08803069
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08711478
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07650839
74AR_25329375_ChIP-Seq_VCAP_Human1.06196393
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06066315
76RNF2_27304074_Chip-Seq_NSC_Mouse1.06028373
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05528053
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05069882
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03137156
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.02705957
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.02309259
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00668397
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99177278
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98360558
85TP53_22573176_ChIP-Seq_HFKS_Human0.97315014
86P53_22387025_ChIP-Seq_ESCs_Mouse0.96400287
87DCP1A_22483619_ChIP-Seq_HELA_Human0.95231702
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94870623
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94407892
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94315712
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.93909691
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93249925
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.92138935
94AR_20517297_ChIP-Seq_VCAP_Human0.91712918
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91291633
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.88282439
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86775081
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.86655115
99REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85648724
100SMRT_27268052_Chip-Seq_Bcells_Human0.84120751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.24857877
2MP0003880_abnormal_central_pattern4.81571813
3MP0002837_dystrophic_cardiac_calcinosis4.24640435
4MP0002102_abnormal_ear_morphology3.25971786
5MP0005499_abnormal_olfactory_system3.24748655
6MP0005394_taste/olfaction_phenotype3.24748655
7MP0000579_abnormal_nail_morphology2.85303116
8MP0001984_abnormal_olfaction2.68514264
9MP0003646_muscle_fatigue2.49670237
10MP0000372_irregular_coat_pigmentation2.31629886
11MP0006292_abnormal_olfactory_placode2.31432577
12MP0001529_abnormal_vocalization2.28171539
13MP0000427_abnormal_hair_cycle2.27169967
14MP0006276_abnormal_autonomic_nervous2.19739940
15MP0008789_abnormal_olfactory_epithelium2.18711866
16MP0000647_abnormal_sebaceous_gland2.15458394
17MP0002638_abnormal_pupillary_reflex2.02979155
18MP0003937_abnormal_limbs/digits/tail_de2.01601527
19MP0005253_abnormal_eye_physiology1.97955481
20MP0003890_abnormal_embryonic-extraembry1.97851624
21MP0002233_abnormal_nose_morphology1.95381171
22MP0009697_abnormal_copulation1.93528685
23MP0003136_yellow_coat_color1.82004750
24MP0003221_abnormal_cardiomyocyte_apopto1.80656722
25MP0006072_abnormal_retinal_apoptosis1.78226650
26MP0000751_myopathy1.76396196
27MP0000049_abnormal_middle_ear1.64491285
28MP0005551_abnormal_eye_electrophysiolog1.60807346
29MP0005075_abnormal_melanosome_morpholog1.57488398
30MP0002234_abnormal_pharynx_morphology1.57246894
31MP0003755_abnormal_palate_morphology1.45259415
32MP0002095_abnormal_skin_pigmentation1.43585199
33MP0002282_abnormal_trachea_morphology1.42005841
34MP0003195_calcinosis1.40437037
35MP0005085_abnormal_gallbladder_physiolo1.39846821
36MP0002249_abnormal_larynx_morphology1.34571767
37MP0002098_abnormal_vibrissa_morphology1.34052764
38MP0004145_abnormal_muscle_electrophysio1.29146945
39MP0002751_abnormal_autonomic_nervous1.28103800
40MP0001324_abnormal_eye_pigmentation1.25199008
41MP0005391_vision/eye_phenotype1.25093108
42MP0000778_abnormal_nervous_system1.17117123
43MP0003186_abnormal_redox_activity1.16667722
44MP0008007_abnormal_cellular_replicative1.15725045
45MP0002295_abnormal_pulmonary_circulatio1.14795342
46MP0005360_urolithiasis1.12450103
47MP0001293_anophthalmia1.10589152
48MP0009046_muscle_twitch1.08124661
49MP0001486_abnormal_startle_reflex1.06812017
50MP0003122_maternal_imprinting1.06804162
51MP0005171_absent_coat_pigmentation1.05771563
52MP0005365_abnormal_bile_salt1.04181230
53MP0001177_atelectasis1.03083701
54MP0010307_abnormal_tumor_latency0.94072802
55MP0001849_ear_inflammation0.93061001
56MP0003045_fibrosis0.91839165
57MP0001764_abnormal_homeostasis0.90782150
58MP0002109_abnormal_limb_morphology0.90129703
59MP0002822_catalepsy0.90050305
60MP0003938_abnormal_ear_development0.88556371
61MP0008058_abnormal_DNA_repair0.86252845
62MP0003567_abnormal_fetal_cardiomyocyte0.85253614
63MP0005187_abnormal_penis_morphology0.84219534
64MP0003942_abnormal_urinary_system0.83976406
65MP0001502_abnormal_circadian_rhythm0.83217989
66MP0002752_abnormal_somatic_nervous0.80359332
67MP0005386_behavior/neurological_phenoty0.79636492
68MP0004924_abnormal_behavior0.79636492
69MP0004270_analgesia0.79594101
70MP0002272_abnormal_nervous_system0.78898903
71MP0002111_abnormal_tail_morphology0.78500262
72MP0009745_abnormal_behavioral_response0.75965941
73MP0003935_abnormal_craniofacial_develop0.74954076
74MP0001286_abnormal_eye_development0.72775287
75MP0002882_abnormal_neuron_morphology0.71695549
76MP0003698_abnormal_male_reproductive0.71478796
77MP0002092_abnormal_eye_morphology0.69848772
78MP0003137_abnormal_impulse_conducting0.68722487
79MP0004215_abnormal_myocardial_fiber0.67898197
80MP0000371_diluted_coat_color0.67305812
81MP0002938_white_spotting0.66650490
82MP0000377_abnormal_hair_follicle0.66461935
83MP0001963_abnormal_hearing_physiology0.66331300
84MP0002557_abnormal_social/conspecific_i0.66083363
85MP0001970_abnormal_pain_threshold0.64620914
86MP0002177_abnormal_outer_ear0.62752015
87MP0003385_abnormal_body_wall0.61274315
88MP0002063_abnormal_learning/memory/cond0.60160957
89MP0004142_abnormal_muscle_tone0.60075968
90MP0005195_abnormal_posterior_eye0.59680530
91MP0001661_extended_life_span0.58248633
92MP0000749_muscle_degeneration0.56906458
93MP0002152_abnormal_brain_morphology0.55604284
94MP0001485_abnormal_pinna_reflex0.55545591
95MP0001968_abnormal_touch/_nociception0.54673824
96MP0002084_abnormal_developmental_patter0.54135356
97MP0001243_abnormal_dermal_layer0.53699771
98MP0003861_abnormal_nervous_system0.53022668
99MP0004043_abnormal_pH_regulation0.52144900
100MP0002736_abnormal_nociception_after0.51531675

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.59151010
2Lipid accumulation in hepatocytes (HP:0006561)4.36259485
3Congenital primary aphakia (HP:0007707)4.31463435
4Gait imbalance (HP:0002141)4.27455216
5Nephrogenic diabetes insipidus (HP:0009806)4.02024494
6Medial flaring of the eyebrow (HP:0010747)4.01774867
7Panhypogammaglobulinemia (HP:0003139)3.79542958
8Tubulointerstitial nephritis (HP:0001970)3.70943302
9Amyotrophic lateral sclerosis (HP:0007354)3.48528877
10Vaginal atresia (HP:0000148)3.48388987
11Genital tract atresia (HP:0001827)3.35482539
12Decreased testicular size (HP:0008734)3.29057457
13Sensorimotor neuropathy (HP:0007141)3.24696513
14Follicular hyperkeratosis (HP:0007502)3.15356427
15Poor coordination (HP:0002370)3.08773813
16Axonal loss (HP:0003447)3.07583411
17Renal Fanconi syndrome (HP:0001994)3.05776675
18True hermaphroditism (HP:0010459)3.01808174
19Broad foot (HP:0001769)2.90542882
20Adactyly (HP:0009776)2.89114580
21Abolished electroretinogram (ERG) (HP:0000550)2.87187359
22Pancreatic cysts (HP:0001737)2.77737074
23Hepatocellular necrosis (HP:0001404)2.76172969
24Respiratory difficulties (HP:0002880)2.71154274
25Thyroid-stimulating hormone excess (HP:0002925)2.69840330
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59161199
27Atrophy/Degeneration involving motor neurons (HP:0007373)2.52384184
28Broad alveolar ridges (HP:0000187)2.50517058
29Pancreatic fibrosis (HP:0100732)2.50481143
30Chronic mucocutaneous candidiasis (HP:0002728)2.50299169
31Recurrent cutaneous fungal infections (HP:0011370)2.50299169
32Ketoacidosis (HP:0001993)2.49228811
33Hepatic necrosis (HP:0002605)2.46309108
34Increased intramyocellular lipid droplets (HP:0012240)2.45412364
35Exertional dyspnea (HP:0002875)2.44125283
36Intestinal atresia (HP:0011100)2.41574798
37Progressive cerebellar ataxia (HP:0002073)2.41181589
38Partial agenesis of the corpus callosum (HP:0001338)2.40708814
39Peripheral hypomyelination (HP:0007182)2.36196407
40Febrile seizures (HP:0002373)2.36113422
41Aplasia/Hypoplasia of the lens (HP:0008063)2.35518764
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.35387374
43Progressive inability to walk (HP:0002505)2.35305884
44Conjunctival telangiectasia (HP:0000524)2.35099550
45Molar tooth sign on MRI (HP:0002419)2.34387830
46Abnormality of midbrain morphology (HP:0002418)2.34387830
47Sclerocornea (HP:0000647)2.22772109
48Abnormality of DNA repair (HP:0003254)2.19047125
49Increased muscle lipid content (HP:0009058)2.18846812
50Septo-optic dysplasia (HP:0100842)2.16752511
51Pendular nystagmus (HP:0012043)2.16299231
52Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12592168
53Spontaneous hematomas (HP:0007420)2.11917445
54Severe global developmental delay (HP:0011344)2.11742070
55Split foot (HP:0001839)2.09577804
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.05779743
57Renal cortical cysts (HP:0000803)2.05755482
58Widely spaced teeth (HP:0000687)2.04777719
59Abnormality of renal resorption (HP:0011038)2.03562809
60Abnormality of the antihelix (HP:0009738)2.02583428
61Abnormality of dental color (HP:0011073)2.02443418
62Mitochondrial inheritance (HP:0001427)2.02387829
63Vacuolated lymphocytes (HP:0001922)2.00330328
64Hip dysplasia (HP:0001385)1.98588980
65Vitreoretinal degeneration (HP:0000655)1.98555296
66Drooling (HP:0002307)1.98032724
67Abnormality of chromosome stability (HP:0003220)1.95894762
68Status epilepticus (HP:0002133)1.95767888
69Delayed CNS myelination (HP:0002188)1.95499126
70CNS demyelination (HP:0007305)1.91640645
71Flat capital femoral epiphysis (HP:0003370)1.90946489
72Genetic anticipation (HP:0003743)1.88130920
73Short foot (HP:0001773)1.86850855
74Congenital hepatic fibrosis (HP:0002612)1.86331813
75Hyperphosphaturia (HP:0003109)1.85957420
76Pigmentary retinal degeneration (HP:0001146)1.85671016
77Postaxial hand polydactyly (HP:0001162)1.84752785
78Excessive salivation (HP:0003781)1.84312973
79Severe combined immunodeficiency (HP:0004430)1.84005141
80Micropenis (HP:0000054)1.82600226
81Respiratory failure (HP:0002878)1.82138231
82Astigmatism (HP:0000483)1.81725479
83Volvulus (HP:0002580)1.80452678
84Generalized tonic-clonic seizures (HP:0002069)1.79548691
85Hyperinsulinemic hypoglycemia (HP:0000825)1.79406207
86Increased CSF lactate (HP:0002490)1.78856108
87Chronic hepatic failure (HP:0100626)1.78786923
88Renal hypoplasia (HP:0000089)1.76709328
89Hyperglycinemia (HP:0002154)1.76008336
90Colon cancer (HP:0003003)1.73918563
91Specific learning disability (HP:0001328)1.73287515
92Entropion (HP:0000621)1.72555376
93Hypoglycemic seizures (HP:0002173)1.71311990
94Absent speech (HP:0001344)1.71215273
95Abnormality of the renal medulla (HP:0100957)1.71177626
96Ectropion (HP:0000656)1.67813202
97Decreased central vision (HP:0007663)1.64522640
98Nephronophthisis (HP:0000090)1.63782073
99Woolly hair (HP:0002224)1.63013080
100Ketosis (HP:0001946)1.62757226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.35323783
2TESK24.93612079
3MAP4K24.02564533
4TRIM283.39502819
5STK38L3.05412636
6CASK2.99798646
7EIF2AK12.91574795
8RPS6KA42.55100094
9MAP3K102.33721599
10WNK32.27931585
11EPHA42.25405669
12DYRK32.19301571
13STK392.08912715
14BCR1.96509508
15MKNK21.79368879
16EIF2AK31.77419900
17FRK1.75866016
18OXSR11.70390578
19BMPR21.66198174
20IRAK11.52683689
21MKNK11.51231679
22MARK11.50528885
23BUB11.42354373
24SRPK11.29035889
25MAPK131.19295825
26NUAK11.18587625
27MAPKAPK31.08904788
28DYRK21.04873353
29TNIK1.04699027
30INSRR1.02999112
31DMPK1.02400589
32TESK11.01644612
33NTRK20.97371917
34MST40.97288016
35FER0.96463810
36MAP2K30.95242510
37UHMK10.90961459
38BCKDK0.90398835
39RPS6KA50.90068648
40NLK0.89980083
41PDK20.89494674
42YES10.86427809
43CSNK1G10.86155246
44PLK20.86014774
45CSNK1A1L0.79740241
46MAP2K40.78652575
47DYRK1A0.78542417
48MAP3K40.75916662
49IRAK20.75099949
50VRK10.74831170
51TAOK10.67280047
52STK110.66064321
53CSNK1G30.63556148
54ZAK0.59409836
55LIMK10.55190185
56TNK20.55069671
57CAMKK20.54985135
58CDK50.53830417
59CDK30.53614339
60CSNK1G20.53406198
61FGR0.53120042
62PRKCE0.52632805
63FES0.52445962
64MAP2K70.50912682
65STK160.50136109
66TEC0.49993997
67PIM20.49950060
68ZAP700.49675060
69PASK0.49241336
70ERBB30.46778942
71SIK30.45769137
72TSSK60.44937956
73STK30.44645293
74EIF2AK20.42785591
75RAF10.40621733
76MET0.39599716
77IRAK40.39248202
78MINK10.37322952
79CAMK40.36091467
80ITK0.34755587
81DYRK1B0.33718306
82ACVR1B0.32751786
83ATM0.31357117
84ERBB40.30559052
85MAP3K70.30479476
86PTK2B0.30392390
87AKT30.28727141
88GRK10.28611183
89TXK0.28150714
90CSNK1A10.27247012
91CSK0.26063522
92PAK30.23818479
93PRKACA0.23035007
94MAPK110.21979024
95EPHB20.21922649
96BRSK20.21628170
97JAK30.21357564
98WNK40.20189369
99MAP2K60.20031649
100PRKCQ0.19580333

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.73067216
2Butanoate metabolism_Homo sapiens_hsa006504.44705464
3Protein export_Homo sapiens_hsa030603.74760944
4Steroid biosynthesis_Homo sapiens_hsa001002.82584471
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66276912
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62923616
7Collecting duct acid secretion_Homo sapiens_hsa049662.53386259
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.50554880
9Propanoate metabolism_Homo sapiens_hsa006402.46147853
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24297176
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.20449548
12beta-Alanine metabolism_Homo sapiens_hsa004102.19708541
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08846406
14Nicotine addiction_Homo sapiens_hsa050332.06306762
15Primary immunodeficiency_Homo sapiens_hsa053401.85237319
16Selenocompound metabolism_Homo sapiens_hsa004501.73736798
17Oxidative phosphorylation_Homo sapiens_hsa001901.70712491
18Peroxisome_Homo sapiens_hsa041461.67894008
19Synaptic vesicle cycle_Homo sapiens_hsa047211.46705181
20Retinol metabolism_Homo sapiens_hsa008301.43905444
21Olfactory transduction_Homo sapiens_hsa047401.29343649
22RNA polymerase_Homo sapiens_hsa030201.27191095
23Circadian rhythm_Homo sapiens_hsa047101.25967018
24Fanconi anemia pathway_Homo sapiens_hsa034601.19988852
25Basal transcription factors_Homo sapiens_hsa030221.18310538
26Homologous recombination_Homo sapiens_hsa034401.16682816
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16646822
28GABAergic synapse_Homo sapiens_hsa047271.14018402
29Tryptophan metabolism_Homo sapiens_hsa003801.13455901
30Hedgehog signaling pathway_Homo sapiens_hsa043401.11727987
31mRNA surveillance pathway_Homo sapiens_hsa030151.08079521
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07835703
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07744097
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06979488
35Fatty acid metabolism_Homo sapiens_hsa012121.06780975
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05488694
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01890715
38Nitrogen metabolism_Homo sapiens_hsa009101.00068267
39Fatty acid degradation_Homo sapiens_hsa000710.97303171
40Pyruvate metabolism_Homo sapiens_hsa006200.96203901
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95656391
42Spliceosome_Homo sapiens_hsa030400.94712207
43Basal cell carcinoma_Homo sapiens_hsa052170.93681847
44RNA degradation_Homo sapiens_hsa030180.91341490
45Parkinsons disease_Homo sapiens_hsa050120.89411911
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85268261
47Regulation of autophagy_Homo sapiens_hsa041400.85185091
48Phototransduction_Homo sapiens_hsa047440.84543285
49Chemical carcinogenesis_Homo sapiens_hsa052040.82616534
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80413708
51RNA transport_Homo sapiens_hsa030130.76926176
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69905050
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68732052
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67464128
55Other glycan degradation_Homo sapiens_hsa005110.65886675
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65728351
57Taste transduction_Homo sapiens_hsa047420.63570985
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62983014
59Huntingtons disease_Homo sapiens_hsa050160.61848815
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.61543843
61Vibrio cholerae infection_Homo sapiens_hsa051100.59915519
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56972701
63Hippo signaling pathway_Homo sapiens_hsa043900.53546095
64Wnt signaling pathway_Homo sapiens_hsa043100.52300672
65Glutamatergic synapse_Homo sapiens_hsa047240.50795444
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50002388
67Morphine addiction_Homo sapiens_hsa050320.49821113
68Antigen processing and presentation_Homo sapiens_hsa046120.49624351
69T cell receptor signaling pathway_Homo sapiens_hsa046600.49594931
70Glutathione metabolism_Homo sapiens_hsa004800.49478201
71Metabolic pathways_Homo sapiens_hsa011000.46500723
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45883789
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45582131
74Dopaminergic synapse_Homo sapiens_hsa047280.45518998
75Alcoholism_Homo sapiens_hsa050340.44117830
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43544926
77Arginine and proline metabolism_Homo sapiens_hsa003300.41902851
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41268463
79Glycerolipid metabolism_Homo sapiens_hsa005610.40702976
80ABC transporters_Homo sapiens_hsa020100.36770632
81Glucagon signaling pathway_Homo sapiens_hsa049220.34856220
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32928199
83Linoleic acid metabolism_Homo sapiens_hsa005910.32619462
84Fatty acid elongation_Homo sapiens_hsa000620.32603291
85Ras signaling pathway_Homo sapiens_hsa040140.30730570
86TGF-beta signaling pathway_Homo sapiens_hsa043500.29322060
87Non-homologous end-joining_Homo sapiens_hsa034500.27504791
88Lysine degradation_Homo sapiens_hsa003100.23581840
89Histidine metabolism_Homo sapiens_hsa003400.23561962
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.23444309
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23289884
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23265020
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22348714
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21830630
95Alzheimers disease_Homo sapiens_hsa050100.21632584
96Amphetamine addiction_Homo sapiens_hsa050310.21054058
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20980130
98Carbon metabolism_Homo sapiens_hsa012000.20711911
99FoxO signaling pathway_Homo sapiens_hsa040680.20103955
100Axon guidance_Homo sapiens_hsa043600.18551813

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