DUTP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)7.99507445
2peptidyl-lysine dimethylation (GO:0018027)7.48379618
3dermatan sulfate biosynthetic process (GO:0030208)6.89820187
4histone H3-K9 methylation (GO:0051567)6.58884427
5L-methionine biosynthetic process from methylthioadenosine (GO:0019509)6.52785361
6dermatan sulfate metabolic process (GO:0030205)6.16939132
7cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.85039648
8L-methionine salvage (GO:0071267)5.53288777
9L-methionine biosynthetic process (GO:0071265)5.53288777
10amino acid salvage (GO:0043102)5.53288777
11histone H2A acetylation (GO:0043968)5.36926945
12rRNA catabolic process (GO:0016075)5.34199474
13histone H3-K9 modification (GO:0061647)5.14269232
14negative regulation of mRNA processing (GO:0050686)4.96962327
15spliceosomal tri-snRNP complex assembly (GO:0000244)4.81620726
16response to follicle-stimulating hormone (GO:0032354)4.75158056
17glycine metabolic process (GO:0006544)4.74467373
18heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.72183225
19methionine biosynthetic process (GO:0009086)4.55122482
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.52368897
21somatic hypermutation of immunoglobulin genes (GO:0016446)4.52368897
22alternative mRNA splicing, via spliceosome (GO:0000380)4.49916065
23fibroblast migration (GO:0010761)4.39136771
24isoprenoid biosynthetic process (GO:0008299)4.38418742
25glomerular visceral epithelial cell development (GO:0072015)4.31877727
26microtubule severing (GO:0051013)4.15416202
27methionine metabolic process (GO:0006555)4.02839156
28cellular response to cholesterol (GO:0071397)4.01746048
29peptidyl-lysine methylation (GO:0018022)3.87027468
30acrosome assembly (GO:0001675)3.86498040
31mitochondrial DNA replication (GO:0006264)3.86424956
32organ growth (GO:0035265)3.86045573
33gastrulation with mouth forming second (GO:0001702)3.85355816
34glomerular epithelial cell development (GO:0072310)3.74874233
35oligosaccharide biosynthetic process (GO:0009312)3.73828894
36negative regulation of mRNA metabolic process (GO:1903312)3.71341893
37synaptonemal complex assembly (GO:0007130)3.70726266
38negative regulation of epidermal cell differentiation (GO:0045605)3.68460345
39aspartate family amino acid biosynthetic process (GO:0009067)3.65825622
40L-serine metabolic process (GO:0006563)3.65258059
41peptidyl-histidine modification (GO:0018202)3.64490208
42phosphatidylethanolamine biosynthetic process (GO:0006646)3.60010729
43regulation of non-canonical Wnt signaling pathway (GO:2000050)3.59728007
44myelin assembly (GO:0032288)3.56346490
45sulfur amino acid biosynthetic process (GO:0000097)3.49131773
46left/right axis specification (GO:0070986)3.48476018
47phosphatidylethanolamine metabolic process (GO:0046337)3.47581451
48mitochondrion transport along microtubule (GO:0047497)3.45147995
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.45147995
50regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.44834354
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39328844
52radial glial cell differentiation (GO:0060019)3.38645703
53ncRNA catabolic process (GO:0034661)3.33295716
54L-fucose catabolic process (GO:0042355)3.32714157
55fucose catabolic process (GO:0019317)3.32714157
56L-fucose metabolic process (GO:0042354)3.32714157
57synaptonemal complex organization (GO:0070193)3.32675798
58cholesterol biosynthetic process (GO:0006695)3.29190564
59nonmotile primary cilium assembly (GO:0035058)3.27816239
60cellular response to sterol (GO:0036315)3.24312659
61mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.20876057
62positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.20876057
63tongue development (GO:0043586)3.19413095
64piRNA metabolic process (GO:0034587)3.19062792
65DNA methylation (GO:0006306)3.14993012
66DNA alkylation (GO:0006305)3.14993012
67hematopoietic stem cell proliferation (GO:0071425)3.10286509
68regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.07851004
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.06125795
70mRNA splice site selection (GO:0006376)3.04883776
71establishment of mitochondrion localization (GO:0051654)3.01856978
72aspartate family amino acid catabolic process (GO:0009068)3.01692100
73generation of neurons (GO:0048699)2.96745409
74regulation of translation in response to stress (GO:0043555)2.94299359
75aspartate family amino acid metabolic process (GO:0009066)2.94188684
76translesion synthesis (GO:0019985)2.93138384
77negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.92965070
78serine family amino acid metabolic process (GO:0009069)2.92012304
79purine nucleobase biosynthetic process (GO:0009113)2.91674231
80proteoglycan biosynthetic process (GO:0030166)2.90161202
81serine family amino acid catabolic process (GO:0009071)2.89447184
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.87838680
83tachykinin receptor signaling pathway (GO:0007217)2.87403117
84regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.87266220
85DNA methylation or demethylation (GO:0044728)2.87013741
86positive regulation of guanylate cyclase activity (GO:0031284)2.84920812
87cell wall macromolecule catabolic process (GO:0016998)2.84173205
88response to vitamin E (GO:0033197)2.83455582
89cerebral cortex radially oriented cell migration (GO:0021799)2.81456688
90sterol biosynthetic process (GO:0016126)2.78651526
91serine family amino acid biosynthetic process (GO:0009070)2.78229242
92glomerular basement membrane development (GO:0032836)2.77443039
93retinal rod cell development (GO:0046548)2.76979435
94meiotic chromosome segregation (GO:0045132)2.76130125
95limb bud formation (GO:0060174)2.75821907
96chromosome organization involved in meiosis (GO:0070192)2.73825872
97response to cholesterol (GO:0070723)2.73280173
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70690528
99spermatid development (GO:0007286)2.70608164
100protein-cofactor linkage (GO:0018065)2.68976987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66845832
2GBX2_23144817_ChIP-Seq_PC3_Human4.41412361
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84448761
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.69328857
5ZNF274_21170338_ChIP-Seq_K562_Hela3.27336857
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.16021262
7TAF15_26573619_Chip-Seq_HEK293_Human3.00362096
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97634198
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43808152
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43581252
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33799265
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32472499
13E2F7_22180533_ChIP-Seq_HELA_Human2.23228020
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.21159958
15IGF1R_20145208_ChIP-Seq_DFB_Human2.15689608
16FUS_26573619_Chip-Seq_HEK293_Human2.10735126
17P300_19829295_ChIP-Seq_ESCs_Human2.06397554
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02617796
19IRF1_19129219_ChIP-ChIP_H3396_Human1.98360531
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95562470
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91566441
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87750267
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.84677124
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79080441
25EWS_26573619_Chip-Seq_HEK293_Human1.75983072
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74553092
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.73076377
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72734343
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66605043
30ELK1_19687146_ChIP-ChIP_HELA_Human1.66519266
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60110664
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58875925
33SMAD4_21799915_ChIP-Seq_A2780_Human1.56264555
34AR_25329375_ChIP-Seq_VCAP_Human1.56156254
35MYC_18940864_ChIP-ChIP_HL60_Human1.55277373
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.53723098
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53273081
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50821006
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.50011888
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.46168821
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45912961
42TCF4_23295773_ChIP-Seq_U87_Human1.44977309
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44339768
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42651857
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39092930
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38311080
47SOX9_26525672_Chip-Seq_HEART_Mouse1.37408681
48CBP_20019798_ChIP-Seq_JUKART_Human1.37148339
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37148339
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33975948
51STAT3_23295773_ChIP-Seq_U87_Human1.33716603
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.33515340
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33346689
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.32910569
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28895257
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28589616
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.28020404
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.27216763
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.26300763
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25117502
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.24724749
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.23891473
63VDR_22108803_ChIP-Seq_LS180_Human1.23634321
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.21092014
65ER_23166858_ChIP-Seq_MCF-7_Human1.19691739
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16972216
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.16728700
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14829548
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14579028
70VDR_23849224_ChIP-Seq_CD4+_Human1.13729722
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13634103
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13609888
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.12917869
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10411541
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10229809
76TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09726525
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07073363
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06762280
79KDM5A_27292631_Chip-Seq_BREAST_Human1.06753787
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05891387
81AR_21909140_ChIP-Seq_LNCAP_Human1.03639013
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03630790
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02929084
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02929084
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01841720
86P53_22387025_ChIP-Seq_ESCs_Mouse1.01556731
87CDX2_22108803_ChIP-Seq_LS180_Human1.01541388
88BCAT_22108803_ChIP-Seq_LS180_Human1.01525412
89FOXP3_21729870_ChIP-Seq_TREG_Human1.01076804
90TP53_22573176_ChIP-Seq_HFKS_Human1.00357255
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00040069
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98076044
93TBL1_22424771_ChIP-Seq_293T_Human0.97822165
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97067928
95AR_20517297_ChIP-Seq_VCAP_Human0.94003777
96NCOR_22424771_ChIP-Seq_293T_Human0.93470497
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93245472
98TCF4_22108803_ChIP-Seq_LS180_Human0.91491334
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.91466424
100RUNX2_22187159_ChIP-Seq_PCA_Human0.90809894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting8.13885846
2MP0003705_abnormal_hypodermis_morpholog6.78061783
3MP0008438_abnormal_cutaneous_collagen6.07046881
4MP0005275_abnormal_skin_tensile5.35141273
5MP0002234_abnormal_pharynx_morphology3.36083572
6MP0003121_genomic_imprinting3.31805028
7MP0002102_abnormal_ear_morphology2.44550816
8MP0000569_abnormal_digit_pigmentation2.43323922
9MP0008877_abnormal_DNA_methylation2.34424330
10MP0010094_abnormal_chromosome_stability2.05735933
11MP0008789_abnormal_olfactory_epithelium1.99123606
12MP0000613_abnormal_salivary_gland1.97377885
13MP0002822_catalepsy1.82688075
14MP0002233_abnormal_nose_morphology1.75757225
15MP0008872_abnormal_physiological_respon1.73237980
16MP0002735_abnormal_chemical_nociception1.63970409
17MP0005394_taste/olfaction_phenotype1.59476171
18MP0005499_abnormal_olfactory_system1.59476171
19MP0009703_decreased_birth_body1.58665090
20MP0005551_abnormal_eye_electrophysiolog1.53715080
21MP0005257_abnormal_intraocular_pressure1.49882349
22MP0001529_abnormal_vocalization1.49482236
23MP0003890_abnormal_embryonic-extraembry1.49306281
24MP0002736_abnormal_nociception_after1.42217910
25MP0001984_abnormal_olfaction1.40726153
26MP0002638_abnormal_pupillary_reflex1.33829305
27MP0006072_abnormal_retinal_apoptosis1.30927741
28MP0003880_abnormal_central_pattern1.29765617
29MP0004885_abnormal_endolymph1.26750153
30MP0003191_abnormal_cellular_cholesterol1.23187574
31MP0005253_abnormal_eye_physiology1.20747874
32MP0005646_abnormal_pituitary_gland1.20363279
33MP0005174_abnormal_tail_pigmentation1.18955702
34MP0000778_abnormal_nervous_system1.18782393
35MP0000762_abnormal_tongue_morphology1.18608278
36MP0008058_abnormal_DNA_repair1.16765257
37MP0001293_anophthalmia1.14920442
38MP0004133_heterotaxia1.14699369
39MP0001188_hyperpigmentation1.11018862
40MP0002938_white_spotting1.09255387
41MP0000631_abnormal_neuroendocrine_gland1.08567913
42MP0003221_abnormal_cardiomyocyte_apopto1.07874648
43MP0003937_abnormal_limbs/digits/tail_de1.05595806
44MP0003935_abnormal_craniofacial_develop1.04878724
45MP0003755_abnormal_palate_morphology1.03513989
46MP0001286_abnormal_eye_development1.03397520
47MP0002734_abnormal_mechanical_nocicepti1.03284215
48MP0004858_abnormal_nervous_system1.02496262
49MP0006054_spinal_hemorrhage0.99063703
50MP0009745_abnormal_behavioral_response0.97790805
51MP0005248_abnormal_Harderian_gland0.97641674
52MP0001486_abnormal_startle_reflex0.93356890
53MP0003698_abnormal_male_reproductive0.91941110
54MP0002168_other_aberrant_phenotype0.89493162
55MP0001968_abnormal_touch/_nociception0.88919706
56MP0001929_abnormal_gametogenesis0.85313136
57MP0003119_abnormal_digestive_system0.84004954
58MP0005408_hypopigmentation0.83738154
59MP0002837_dystrophic_cardiac_calcinosis0.82854886
60MP0006292_abnormal_olfactory_placode0.82463864
61MP0005391_vision/eye_phenotype0.81138093
62MP0009046_muscle_twitch0.80688314
63MP0001270_distended_abdomen0.80419965
64MP0000427_abnormal_hair_cycle0.79728466
65MP0002111_abnormal_tail_morphology0.78536225
66MP0002572_abnormal_emotion/affect_behav0.78513353
67MP0005195_abnormal_posterior_eye0.75447983
68MP0004484_altered_response_of0.75271579
69MP0000372_irregular_coat_pigmentation0.74945694
70MP0003943_abnormal_hepatobiliary_system0.70387270
71MP0010386_abnormal_urinary_bladder0.70304097
72MP0002210_abnormal_sex_determination0.69268392
73MP0002557_abnormal_social/conspecific_i0.68755562
74MP0003868_abnormal_feces_composition0.68251580
75MP0001501_abnormal_sleep_pattern0.67954640
76MP0002282_abnormal_trachea_morphology0.67777652
77MP0002928_abnormal_bile_duct0.67767638
78MP0000015_abnormal_ear_pigmentation0.66308088
79MP0004145_abnormal_muscle_electrophysio0.65143281
80MP0002653_abnormal_ependyma_morphology0.65102025
81MP0001970_abnormal_pain_threshold0.64487075
82MP0003045_fibrosis0.63141232
83MP0003861_abnormal_nervous_system0.61050566
84MP0001145_abnormal_male_reproductive0.60975873
85MP0002109_abnormal_limb_morphology0.60753234
86MP0002752_abnormal_somatic_nervous0.59391053
87MP0003950_abnormal_plasma_membrane0.59087927
88MP0001919_abnormal_reproductive_system0.56419685
89MP0004811_abnormal_neuron_physiology0.55870377
90MP0003195_calcinosis0.55186891
91MP0005386_behavior/neurological_phenoty0.53680813
92MP0004924_abnormal_behavior0.53680813
93MP0004270_analgesia0.53444957
94MP0002063_abnormal_learning/memory/cond0.53137719
95MP0002733_abnormal_thermal_nociception0.51834324
96MP0000653_abnormal_sex_gland0.51813867
97MP0002084_abnormal_developmental_patter0.51440378
98MP0000566_synostosis0.51065649
99MP0001545_abnormal_hematopoietic_system0.50922992
100MP0005397_hematopoietic_system_phenotyp0.50922992

Predicted human phenotypes

RankGene SetZ-score
1Patent foramen ovale (HP:0001655)5.67504151
2Hypoplastic pelvis (HP:0008839)5.66522229
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.69512990
4Ependymoma (HP:0002888)4.51621847
5Cerebral hypomyelination (HP:0006808)4.33508957
6Delayed gross motor development (HP:0002194)4.32111626
7Breast hypoplasia (HP:0003187)4.25477089
8Small hand (HP:0200055)4.04012285
9Increased serum pyruvate (HP:0003542)3.77704628
10Astrocytoma (HP:0009592)3.62956303
11Abnormality of the astrocytes (HP:0100707)3.62956303
12Glioma (HP:0009733)3.51381740
13Abnormality of glycolysis (HP:0004366)3.48498914
14Tubular atrophy (HP:0000092)3.44790694
15Hip dysplasia (HP:0001385)3.42354770
16Agnosia (HP:0010524)3.37339617
17Pancreatic cysts (HP:0001737)3.31833114
18Medulloblastoma (HP:0002885)3.06450431
19Pancreatic fibrosis (HP:0100732)3.03866571
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.03101502
21Absent/shortened dynein arms (HP:0200106)3.03101502
22Prominent nose (HP:0000448)2.97403545
23Medial flaring of the eyebrow (HP:0010747)2.95037489
24Premature ovarian failure (HP:0008209)2.91338468
25True hermaphroditism (HP:0010459)2.90262945
26Biliary tract neoplasm (HP:0100574)2.88708988
27Rhabdomyosarcoma (HP:0002859)2.83369235
28Widely spaced teeth (HP:0000687)2.82223689
29Aplastic anemia (HP:0001915)2.78207175
30Delusions (HP:0000746)2.76243078
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63393079
32Impulsivity (HP:0100710)2.62618840
33Hypoplastic female external genitalia (HP:0012815)2.61857170
34Personality changes (HP:0000751)2.60746977
35Hyperventilation (HP:0002883)2.59687135
36Short chin (HP:0000331)2.48211708
37Abnormality of midbrain morphology (HP:0002418)2.44403103
38Molar tooth sign on MRI (HP:0002419)2.44403103
39Neonatal respiratory distress (HP:0002643)2.42099387
40Protruding ear (HP:0000411)2.38555592
41Sclerocornea (HP:0000647)2.35946809
42Gait imbalance (HP:0002141)2.35754331
43Congenital primary aphakia (HP:0007707)2.31785640
44Spondylolisthesis (HP:0003302)2.30872672
45Abnormality of the fingertips (HP:0001211)2.30100114
46Neoplasm of the adrenal cortex (HP:0100641)2.29429788
47Dental crowding (HP:0000678)2.28768491
48Hypoproteinemia (HP:0003075)2.25664462
49Hyperglycinemia (HP:0002154)2.24448397
50Nasal speech (HP:0001611)2.19380906
51Neoplasm of striated muscle (HP:0009728)2.17996646
52Unsteady gait (HP:0002317)2.16090175
53Abnormality of the parathyroid morphology (HP:0011766)2.14143887
54Increased corneal curvature (HP:0100692)2.13661050
55Keratoconus (HP:0000563)2.13661050
56Abnormal spermatogenesis (HP:0008669)2.13384471
57Rhinitis (HP:0012384)2.12865400
58Abnormality of the metopic suture (HP:0005556)2.10789985
59Bulbous nose (HP:0000414)2.07292856
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.07227895
61Cystic liver disease (HP:0006706)2.06570521
62High pitched voice (HP:0001620)2.05477934
63Vaginal atresia (HP:0000148)2.05280285
64Genital tract atresia (HP:0001827)2.04653013
65B lymphocytopenia (HP:0010976)2.02571116
66Postnatal microcephaly (HP:0005484)2.02130856
67Neuroblastic tumors (HP:0004376)2.00803397
68Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.00803397
69Neuroblastoma (HP:0003006)2.00803397
70Primitive neuroectodermal tumor (HP:0030065)2.00803397
71Nephrogenic diabetes insipidus (HP:0009806)1.98962932
72Supernumerary spleens (HP:0009799)1.98929850
73Drooling (HP:0002307)1.95805259
74Abnormality of B cell number (HP:0010975)1.95780989
75CNS hypomyelination (HP:0003429)1.93084096
76Pointed chin (HP:0000307)1.92944223
77Abnormality of the clitoris (HP:0000056)1.91257442
78Small for gestational age (HP:0001518)1.90300694
79Secondary amenorrhea (HP:0000869)1.87551653
80Downturned corners of mouth (HP:0002714)1.85166784
81Tubulointerstitial fibrosis (HP:0005576)1.85129454
82Abnormality of serum amino acid levels (HP:0003112)1.83666313
83Severe combined immunodeficiency (HP:0004430)1.83445397
84Abnormality of the labia minora (HP:0012880)1.83409789
85Neoplasm of the oral cavity (HP:0100649)1.82429478
86Poor speech (HP:0002465)1.82348157
87Congenital hepatic fibrosis (HP:0002612)1.80838142
88Astigmatism (HP:0000483)1.80359783
89Abnormality of the musculature of the hand (HP:0001421)1.78191082
90Hypoalbuminemia (HP:0003073)1.78081892
91Abnormal albumin level (HP:0012116)1.78081892
92Excessive salivation (HP:0003781)1.76214212
93Aplasia/Hypoplasia of the spleen (HP:0010451)1.73884707
94Benign neoplasm of the central nervous system (HP:0100835)1.73157431
95Neuroectodermal neoplasm (HP:0030061)1.72655610
96Neuroepithelial neoplasm (HP:0030063)1.72655610
97Nervous tissue neoplasm (HP:0030060)1.72655610
98Abnormality of the renal cortex (HP:0011035)1.71925464
99Prominent metopic ridge (HP:0005487)1.71195226
100Abnormal ciliary motility (HP:0012262)1.71089253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.89515286
2ZAK4.17554167
3BRD43.80742909
4MAP3K43.74934079
5CDC73.64670261
6MAP2K73.08842349
7PINK12.64012161
8TRIM282.56482563
9FRK2.47897209
10EIF2AK32.35671519
11DYRK22.19746380
12NUAK12.09351784
13MAP4K22.01361831
14CSNK1G12.01216877
15ACVR1B1.89920084
16AKT31.60587432
17MAP2K41.60050720
18MAPK131.56175040
19ERBB31.54040103
20ADRBK21.45530856
21MAP3K61.43947353
22MAP3K51.42626611
23BMPR1B1.41254672
24AKT21.32531443
25MARK11.29178679
26CCNB11.20041890
27FLT31.16912910
28PLK41.15230641
29MINK11.11584593
30PAK31.07747424
31EIF2AK11.06232777
32PKN21.05236863
33BCR0.95508533
34PLK20.94269875
35MAP3K100.93220441
36STK390.92311888
37SIK20.91479368
38ADRBK10.91117098
39VRK10.90086099
40TTK0.87693638
41TRPM70.87297075
42NEK10.86078113
43SGK20.80111847
44PLK30.79870245
45YES10.78208170
46UHMK10.77003330
47OXSR10.74798517
48ATR0.73964913
49NTRK20.72144947
50MUSK0.71955842
51PRKCE0.70287585
52PLK10.69505654
53GRK10.69392940
54ATM0.64844026
55TIE10.63397562
56CDK190.61660088
57NLK0.57980346
58BCKDK0.57362229
59MET0.57024030
60PRKG10.52996957
61MST40.52813020
62PHKG20.52614248
63PHKG10.52614248
64SGK2230.51996531
65SGK4940.51996531
66CDK30.51150506
67CASK0.49005018
68CDK80.47918842
69MKNK20.46493827
70STK100.44957044
71TNIK0.44788415
72MAP3K120.44037284
73CSNK1G30.42464872
74GSK3A0.42175178
75PKN10.42167783
76PRKDC0.41666635
77EPHA40.41294198
78AURKB0.40488017
79TGFBR10.40448203
80TYRO30.40445605
81INSRR0.38920169
82CDK10.38708433
83CAMKK20.38275332
84RPS6KA50.37023405
85CSNK1G20.35369724
86PRKCH0.33879838
87SRPK10.33104000
88GSK3B0.32924680
89PRKCG0.32502336
90PRKCI0.30079722
91MAPK70.29662146
92LATS10.29156886
93JAK10.29090464
94CSNK1A10.28299850
95PRKACB0.28284325
96TAOK30.26757608
97OBSCN0.26334569
98WNK40.25704982
99PIK3CA0.25389380
100ABL10.25301933

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.79570703
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.19096405
3Mismatch repair_Homo sapiens_hsa034303.45836490
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.34256734
5Steroid biosynthesis_Homo sapiens_hsa001002.91321106
6Butanoate metabolism_Homo sapiens_hsa006502.86274582
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73340047
8One carbon pool by folate_Homo sapiens_hsa006702.70184170
9Non-homologous end-joining_Homo sapiens_hsa034502.61263656
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.57911655
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.48710928
12Phototransduction_Homo sapiens_hsa047442.31597054
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29857839
14Lysine degradation_Homo sapiens_hsa003102.19744780
15Selenocompound metabolism_Homo sapiens_hsa004501.83414612
16DNA replication_Homo sapiens_hsa030301.82162030
17Fanconi anemia pathway_Homo sapiens_hsa034601.75059650
18Nucleotide excision repair_Homo sapiens_hsa034201.59789958
19RNA degradation_Homo sapiens_hsa030181.57795689
20Homologous recombination_Homo sapiens_hsa034401.52432421
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41232148
22Propanoate metabolism_Homo sapiens_hsa006401.31581342
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25212691
24Tryptophan metabolism_Homo sapiens_hsa003801.15912294
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09680367
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06868638
27Basal transcription factors_Homo sapiens_hsa030221.04795592
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02371277
29Fat digestion and absorption_Homo sapiens_hsa049751.01112982
30Linoleic acid metabolism_Homo sapiens_hsa005910.96418035
31Circadian rhythm_Homo sapiens_hsa047100.96010008
32RNA polymerase_Homo sapiens_hsa030200.92838489
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90719211
34Taste transduction_Homo sapiens_hsa047420.89089717
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85391246
36Base excision repair_Homo sapiens_hsa034100.84478957
37Pyrimidine metabolism_Homo sapiens_hsa002400.78650219
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.77070083
39Fatty acid metabolism_Homo sapiens_hsa012120.74223853
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73856501
41Protein export_Homo sapiens_hsa030600.71986612
42Ether lipid metabolism_Homo sapiens_hsa005650.70348582
43Regulation of autophagy_Homo sapiens_hsa041400.69443837
44Dopaminergic synapse_Homo sapiens_hsa047280.65977215
45Amphetamine addiction_Homo sapiens_hsa050310.63950946
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62249313
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61113482
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59967863
49Fatty acid degradation_Homo sapiens_hsa000710.57157314
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56845175
51RNA transport_Homo sapiens_hsa030130.55749806
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53213949
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.53125920
54Purine metabolism_Homo sapiens_hsa002300.52485983
55TGF-beta signaling pathway_Homo sapiens_hsa043500.51967744
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51206026
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48902249
58Salivary secretion_Homo sapiens_hsa049700.46905845
59Cocaine addiction_Homo sapiens_hsa050300.46889555
60Thyroid hormone synthesis_Homo sapiens_hsa049180.46752214
61Chemical carcinogenesis_Homo sapiens_hsa052040.46181476
62Glucagon signaling pathway_Homo sapiens_hsa049220.45829607
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43513919
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42632246
65Insulin secretion_Homo sapiens_hsa049110.41282785
66Spliceosome_Homo sapiens_hsa030400.40983837
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.40784858
68Arachidonic acid metabolism_Homo sapiens_hsa005900.40441082
69Metabolic pathways_Homo sapiens_hsa011000.40413585
70mRNA surveillance pathway_Homo sapiens_hsa030150.40317639
71Sphingolipid metabolism_Homo sapiens_hsa006000.39495048
72Alcoholism_Homo sapiens_hsa050340.37828025
73Nicotine addiction_Homo sapiens_hsa050330.37751952
74Primary immunodeficiency_Homo sapiens_hsa053400.36965900
75Circadian entrainment_Homo sapiens_hsa047130.35122614
76AMPK signaling pathway_Homo sapiens_hsa041520.31834790
77Pyruvate metabolism_Homo sapiens_hsa006200.31215567
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31169519
79Olfactory transduction_Homo sapiens_hsa047400.31121995
80Calcium signaling pathway_Homo sapiens_hsa040200.31072122
81Glutamatergic synapse_Homo sapiens_hsa047240.30376998
82Glycerolipid metabolism_Homo sapiens_hsa005610.29162528
83Cholinergic synapse_Homo sapiens_hsa047250.28723409
84Proteasome_Homo sapiens_hsa030500.27844205
85Nitrogen metabolism_Homo sapiens_hsa009100.27090239
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24808399
87Morphine addiction_Homo sapiens_hsa050320.23541171
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22699977
89GABAergic synapse_Homo sapiens_hsa047270.22168708
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20581335
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20153639
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20059039
93Ovarian steroidogenesis_Homo sapiens_hsa049130.19213419
94Complement and coagulation cascades_Homo sapiens_hsa046100.19107808
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18754355
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15020829
97Systemic lupus erythematosus_Homo sapiens_hsa053220.14650682
98Serotonergic synapse_Homo sapiens_hsa047260.14192693
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13511382
100Choline metabolism in cancer_Homo sapiens_hsa052310.12487071

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