DUX4L18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cell maturation (GO:1903429)7.68812450
2interleukin-6-mediated signaling pathway (GO:0070102)7.64982845
3histone H3-K4 trimethylation (GO:0080182)7.49310474
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.77070608
5regulation of acrosome reaction (GO:0060046)6.63964815
6histone-serine phosphorylation (GO:0035404)6.29110890
72-deoxyribonucleotide biosynthetic process (GO:0009265)6.28838270
8deoxyribose phosphate biosynthetic process (GO:0046385)6.28838270
9protein localization to microtubule cytoskeleton (GO:0072698)6.16096762
10positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)5.66545672
11neuron fate determination (GO:0048664)5.63988287
12acrosome reaction (GO:0007340)5.56514479
13positive regulation of oligodendrocyte differentiation (GO:0048714)5.44946339
14positive regulation of histone H3-K4 methylation (GO:0051571)5.30222043
15protein localization to cytoskeleton (GO:0044380)5.21796445
16regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.13952512
17positive regulation of DNA-templated transcription, initiation (GO:2000144)5.07997504
18histone H2B ubiquitination (GO:0033523)4.83614981
19epithelial cell fate commitment (GO:0072148)4.81843200
20astrocyte differentiation (GO:0048708)4.79163247
21protein-chromophore linkage (GO:0018298)4.71435998
22proline transport (GO:0015824)4.53328524
23spliceosomal complex assembly (GO:0000245)4.50778865
24cell fate commitment involved in formation of primary germ layer (GO:0060795)4.45700028
25glycine transport (GO:0015816)4.44329049
26tachykinin receptor signaling pathway (GO:0007217)4.32958112
27positive regulation of T cell differentiation in thymus (GO:0033089)4.20385191
28spinal cord motor neuron differentiation (GO:0021522)4.17006095
29adult feeding behavior (GO:0008343)4.07794233
30deoxyribonucleotide biosynthetic process (GO:0009263)4.06884343
31peptidyl-lysine trimethylation (GO:0018023)3.95911066
32positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.91855990
33multicellular organism reproduction (GO:0032504)3.91627297
34centrosome localization (GO:0051642)3.90650079
35sperm capacitation (GO:0048240)3.83611304
36regulation of oligodendrocyte differentiation (GO:0048713)3.74392558
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.73422449
38dentate gyrus development (GO:0021542)3.70693195
39pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.69669589
40response to folic acid (GO:0051593)3.69010551
41detection of light stimulus involved in visual perception (GO:0050908)3.69003555
42detection of light stimulus involved in sensory perception (GO:0050962)3.69003555
43myelin assembly (GO:0032288)3.68333889
44purinergic nucleotide receptor signaling pathway (GO:0035590)3.66519035
45regulation of spindle organization (GO:0090224)3.66466119
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.55691164
47sulfate transmembrane transport (GO:1902358)3.53796778
48deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.50769697
49positive regulation of uterine smooth muscle contraction (GO:0070474)3.45448192
50cellular response to interleukin-6 (GO:0071354)3.45430923
51C4-dicarboxylate transport (GO:0015740)3.41288499
52calcium ion import (GO:0070509)3.39811207
53positive regulation of glial cell differentiation (GO:0045687)3.39033647
54pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.38443905
55type B pancreatic cell development (GO:0003323)3.38238267
56glycerol ether metabolic process (GO:0006662)3.34266865
57rhodopsin mediated signaling pathway (GO:0016056)3.28381497
58regulation of calcium ion-dependent exocytosis (GO:0017158)3.28114120
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25578879
60glyoxylate metabolic process (GO:0046487)3.25144774
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.23964599
62central nervous system projection neuron axonogenesis (GO:0021952)3.23779932
63tongue development (GO:0043586)3.21239417
64regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.21149571
65urinary tract smooth muscle contraction (GO:0014848)3.19404117
66inner ear receptor cell development (GO:0060119)3.18482847
67forebrain neuron differentiation (GO:0021879)3.18347717
68positive regulation of vascular permeability (GO:0043117)3.18213319
69regulation of spindle checkpoint (GO:0090231)3.15481528
70piRNA metabolic process (GO:0034587)3.13149650
71reciprocal meiotic recombination (GO:0007131)3.11150400
72reciprocal DNA recombination (GO:0035825)3.11150400
73ether metabolic process (GO:0018904)3.10009667
74negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.09956716
75cellular ketone body metabolic process (GO:0046950)3.04745867
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03418803
77reflex (GO:0060004)3.02896615
78phasic smooth muscle contraction (GO:0014821)3.00172189
79intestinal epithelial cell development (GO:0060576)2.98086939
80neuronal stem cell maintenance (GO:0097150)2.96246640
81peristalsis (GO:0030432)2.90488949
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88290204
83indolalkylamine metabolic process (GO:0006586)2.87634585
84kynurenine metabolic process (GO:0070189)2.86243503
85peptidyl-lysine methylation (GO:0018022)2.86203816
86negative regulation of glycogen biosynthetic process (GO:0045719)2.84170251
87sensory perception of taste (GO:0050909)2.84011372
88sulfate transport (GO:0008272)2.81593801
89artery development (GO:0060840)2.81557237
90mitochondrial calcium ion transport (GO:0006851)2.81286574
91regulation of DNA-templated transcription, initiation (GO:2000142)2.78890530
92regulation of gonadotropin secretion (GO:0032276)2.77536240
93alanine transport (GO:0032328)2.74920883
94response to interleukin-6 (GO:0070741)2.72529790
95histone H3-K4 methylation (GO:0051568)2.72252464
96olfactory bulb development (GO:0021772)2.71201540
97regulation of gene expression by genetic imprinting (GO:0006349)2.70336431
98ketone body metabolic process (GO:1902224)2.70079129
99neuron fate specification (GO:0048665)2.69731102
100cell differentiation in spinal cord (GO:0021515)2.69086215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.49708157
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00754787
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.87356096
4VDR_22108803_ChIP-Seq_LS180_Human3.75342187
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.72373537
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.66463781
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70254562
8E2F7_22180533_ChIP-Seq_HELA_Human2.58821357
9EZH2_22144423_ChIP-Seq_EOC_Human2.45605888
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42675466
11TAF15_26573619_Chip-Seq_HEK293_Human2.13919794
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02672082
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89716743
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.87407502
15EGR1_19032775_ChIP-ChIP_M12_Human1.81306071
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78487048
17IGF1R_20145208_ChIP-Seq_DFB_Human1.78471331
18IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76851510
19CBP_20019798_ChIP-Seq_JUKART_Human1.76851510
20SCL_19346495_ChIP-Seq_HPC-7_Human1.74297301
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.71336150
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69253363
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63205808
24AR_21572438_ChIP-Seq_LNCaP_Human1.62985469
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62826954
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61539675
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57420187
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.53200653
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51390219
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48021872
31BCAT_22108803_ChIP-Seq_LS180_Human1.45682035
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45519044
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40234044
34DROSHA_22980978_ChIP-Seq_HELA_Human1.38819867
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37244555
36GBX2_23144817_ChIP-Seq_PC3_Human1.34960499
37E2F1_20622854_ChIP-Seq_HELA_Human1.34133680
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32641611
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.31318755
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31262637
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.30053143
42REST_21632747_ChIP-Seq_MESCs_Mouse1.27592387
43NANOG_19829295_ChIP-Seq_ESCs_Human1.25311133
44SOX2_19829295_ChIP-Seq_ESCs_Human1.25311133
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25028196
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23776628
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22737495
48NANOG_20526341_ChIP-Seq_ESCs_Human1.20625043
49ZNF274_21170338_ChIP-Seq_K562_Hela1.20129574
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19878963
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.19337226
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18580060
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16724748
54FUS_26573619_Chip-Seq_HEK293_Human1.16630259
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15647574
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14733657
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.14654794
58TCF4_23295773_ChIP-Seq_U87_Human1.14365970
59TP53_22573176_ChIP-Seq_HFKS_Human1.13937943
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13847878
61TAF2_19829295_ChIP-Seq_ESCs_Human1.11373876
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09335404
63RXR_22108803_ChIP-Seq_LS180_Human1.08819366
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07440505
65BCL6_27268052_Chip-Seq_Bcells_Human1.06970371
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06697827
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.06697827
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06352595
69STAT3_23295773_ChIP-Seq_U87_Human1.05892862
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05886593
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04955838
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04621630
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04005139
74WDR5_24793694_ChIP-Seq_LNCAP_Human1.03190284
75P300_19829295_ChIP-Seq_ESCs_Human1.01922766
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.00096826
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99003594
78PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98874187
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96384722
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96045253
81EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94654424
82RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94654424
83SMAD4_21799915_ChIP-Seq_A2780_Human0.94378259
84EWS_26573619_Chip-Seq_HEK293_Human0.93326361
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93043919
86KDM2B_26808549_Chip-Seq_REH_Human0.92759408
87P300_27268052_Chip-Seq_Bcells_Human0.92659814
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91772546
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91532491
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91385700
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91078840
92MYC_19829295_ChIP-Seq_ESCs_Human0.90659415
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90573664
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.87064792
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.85808806
96TCF4_22108803_ChIP-Seq_LS180_Human0.85419305
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.85415809
98MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85095722
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.85043352
100CEBPB_22108803_ChIP-Seq_LS180_Human0.83811021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.15636244
2MP0003878_abnormal_ear_physiology4.14498578
3MP0005377_hearing/vestibular/ear_phenot4.14498578
4MP0003183_abnormal_peptide_metabolism3.91931369
5MP0002638_abnormal_pupillary_reflex3.85860909
6MP0003693_abnormal_embryo_hatching3.52041995
7MP0002735_abnormal_chemical_nociception2.73950961
8MP0003195_calcinosis2.57292656
9MP0008877_abnormal_DNA_methylation2.52474544
10MP0009780_abnormal_chondrocyte_physiolo2.51415152
11MP0001968_abnormal_touch/_nociception2.48169331
12MP0005551_abnormal_eye_electrophysiolog2.30405834
13MP0003045_fibrosis2.26431601
14MP0003646_muscle_fatigue2.17746259
15MP0002102_abnormal_ear_morphology2.17487025
16MP0005645_abnormal_hypothalamus_physiol2.13030454
17MP0001764_abnormal_homeostasis2.12458449
18MP0003950_abnormal_plasma_membrane2.07037807
19MP0006276_abnormal_autonomic_nervous2.05820642
20MP0003787_abnormal_imprinting2.01839684
21MP0005253_abnormal_eye_physiology1.86826188
22MP0002653_abnormal_ependyma_morphology1.73242252
23MP0003880_abnormal_central_pattern1.65637916
24MP0003879_abnormal_hair_cell1.63607166
25MP0003136_yellow_coat_color1.60066942
26MP0006072_abnormal_retinal_apoptosis1.59828778
27MP0001984_abnormal_olfaction1.58513969
28MP0000372_irregular_coat_pigmentation1.53210137
29MP0005075_abnormal_melanosome_morpholog1.53129164
30MP0001485_abnormal_pinna_reflex1.52291988
31MP0000569_abnormal_digit_pigmentation1.51697749
32MP0000383_abnormal_hair_follicle1.49733899
33MP0005410_abnormal_fertilization1.47470022
34MP0001986_abnormal_taste_sensitivity1.47187889
35MP0004381_abnormal_hair_follicle1.46042542
36MP0004924_abnormal_behavior1.36714537
37MP0005386_behavior/neurological_phenoty1.36714537
38MP0002272_abnormal_nervous_system1.35602328
39MP0000026_abnormal_inner_ear1.32533828
40MP0005671_abnormal_response_to1.27888091
41MP0001970_abnormal_pain_threshold1.26050334
42MP0005646_abnormal_pituitary_gland1.25591607
43MP0002733_abnormal_thermal_nociception1.24855065
44MP0003252_abnormal_bile_duct1.22277478
45MP0009046_muscle_twitch1.22089994
46MP0004142_abnormal_muscle_tone1.21384927
47MP0010386_abnormal_urinary_bladder1.20652818
48MP0005360_urolithiasis1.16076440
49MP0001502_abnormal_circadian_rhythm1.14399141
50MP0009053_abnormal_anal_canal1.13526541
51MP0002168_other_aberrant_phenotype1.12753483
52MP0005266_abnormal_metabolism1.11462373
53MP0001486_abnormal_startle_reflex1.08305738
54MP0002837_dystrophic_cardiac_calcinosis1.07642697
55MP0008872_abnormal_physiological_respon1.07439623
56MP0009697_abnormal_copulation1.06995071
57MP0001963_abnormal_hearing_physiology1.06274528
58MP0001664_abnormal_digestion1.05051205
59MP0010678_abnormal_skin_adnexa1.02230023
60MP0002163_abnormal_gland_morphology0.98078697
61MP0003635_abnormal_synaptic_transmissio0.97453232
62MP0005195_abnormal_posterior_eye0.95384752
63MP0004036_abnormal_muscle_relaxation0.95350094
64MP0005171_absent_coat_pigmentation0.95237358
65MP0002736_abnormal_nociception_after0.93646132
66MP0003959_abnormal_lean_body0.93049629
67MP0003137_abnormal_impulse_conducting0.93034611
68MP0002751_abnormal_autonomic_nervous0.88462474
69MP0008789_abnormal_olfactory_epithelium0.87583251
70MP0004043_abnormal_pH_regulation0.82546207
71MP0003698_abnormal_male_reproductive0.81611637
72MP0003122_maternal_imprinting0.81465898
73MP0004019_abnormal_vitamin_homeostasis0.81011717
74MP0005376_homeostasis/metabolism_phenot0.78917513
75MP0001756_abnormal_urination0.77438680
76MP0002229_neurodegeneration0.74315294
77MP0009764_decreased_sensitivity_to0.73142890
78MP0002752_abnormal_somatic_nervous0.70997134
79MP0001929_abnormal_gametogenesis0.70953805
80MP0009745_abnormal_behavioral_response0.69558196
81MP0002064_seizures0.69135872
82MP0002067_abnormal_sensory_capabilities0.68501320
83MP0002572_abnormal_emotion/affect_behav0.68386107
84MP0009250_abnormal_appendicular_skeleto0.68347360
85MP0002693_abnormal_pancreas_physiology0.68226894
86MP0001501_abnormal_sleep_pattern0.68056091
87MP0003385_abnormal_body_wall0.67309980
88MP0003763_abnormal_thymus_physiology0.66528404
89MP0001324_abnormal_eye_pigmentation0.66111733
90MP0003638_abnormal_response/metabolism_0.66089805
91MP0005448_abnormal_energy_balance0.65662598
92MP0002734_abnormal_mechanical_nocicepti0.63362501
93MP0001905_abnormal_dopamine_level0.62639838
94MP0002160_abnormal_reproductive_system0.60547774
95MP0000470_abnormal_stomach_morphology0.58985855
96MP0003191_abnormal_cellular_cholesterol0.55433742
97MP0002098_abnormal_vibrissa_morphology0.55328642
98MP0005499_abnormal_olfactory_system0.54427644
99MP0005394_taste/olfaction_phenotype0.54427644
100MP0003077_abnormal_cell_cycle0.51623293

Predicted human phenotypes

RankGene SetZ-score
1Dry hair (HP:0011359)5.49777319
2Autoimmune thrombocytopenia (HP:0001973)5.49631778
3Decreased circulating renin level (HP:0003351)5.49216549
4Volvulus (HP:0002580)4.97293649
5Constricted visual fields (HP:0001133)4.59755117
6Radial bowing (HP:0002986)4.48825996
7Short 1st metacarpal (HP:0010034)4.32174140
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.32174140
9Abnormality of proline metabolism (HP:0010907)4.03219366
10Hydroxyprolinuria (HP:0003080)4.03219366
11Intrahepatic cholestasis (HP:0001406)3.89329071
12Pigmentary retinal degeneration (HP:0001146)3.85626470
13Abnormality of the 1st metacarpal (HP:0010009)3.84680155
14Bony spicule pigmentary retinopathy (HP:0007737)3.44314194
15Long clavicles (HP:0000890)3.41776901
16Abolished electroretinogram (ERG) (HP:0000550)3.40119641
17Truncal obesity (HP:0001956)3.27471462
18Aplastic anemia (HP:0001915)3.14111057
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03519448
20Abnormality of renin-angiotensin system (HP:0000847)3.01246112
21Short phalanx of the thumb (HP:0009660)2.91695751
22Hyperactive renin-angiotensin system (HP:0000841)2.88256908
23Bilateral sensorineural hearing impairment (HP:0008619)2.86503748
24Decreased central vision (HP:0007663)2.84630154
25Autoimmune hemolytic anemia (HP:0001890)2.69953865
26Thoracic kyphosis (HP:0002942)2.69407737
27Amelogenesis imperfecta (HP:0000705)2.69129380
28Bowed forearm bones (HP:0003956)2.62648250
29Bowing of the arm (HP:0006488)2.62648250
30Abnormality of the prostate (HP:0008775)2.61142259
31Poor speech (HP:0002465)2.57159793
32Alkalosis (HP:0001948)2.56688452
33Hypoplastic iliac wings (HP:0002866)2.56054964
34Choroideremia (HP:0001139)2.51147148
35Confusion (HP:0001289)2.46967952
36Fibular aplasia (HP:0002990)2.44588046
37Mesangial abnormality (HP:0001966)2.40172378
38Steatorrhea (HP:0002570)2.38904822
39Optic disc pallor (HP:0000543)2.37429179
40Hyperglycinuria (HP:0003108)2.36803280
41Hypotrichosis (HP:0001006)2.36238608
42Hypoplastic ischia (HP:0003175)2.32218853
43Abnormality of the renal collecting system (HP:0004742)2.31502754
44Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.27850154
45Lissencephaly (HP:0001339)2.23865669
46Vertebral arch anomaly (HP:0008438)2.23736805
47Hypokalemic alkalosis (HP:0001949)2.18374124
48Attenuation of retinal blood vessels (HP:0007843)2.18205042
49Reduced antithrombin III activity (HP:0001976)2.15200439
50Broad hallux (HP:0010055)2.14951950
51Abnormality of the nasal septum (HP:0000419)2.13897553
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12913649
53Hyperaldosteronism (HP:0000859)2.10578270
54Hyperkalemia (HP:0002153)2.09807442
55Pendular nystagmus (HP:0012043)2.09548323
56Short middle phalanx of finger (HP:0005819)2.09218119
57Hypokalemia (HP:0002900)2.08848160
58Mesomelia (HP:0003027)2.05448002
59Congenital stationary night blindness (HP:0007642)2.02531636
60Rhabdomyosarcoma (HP:0002859)2.01525070
61Cerebral aneurysm (HP:0004944)2.00716660
62Increased corneal curvature (HP:0100692)1.97705396
63Keratoconus (HP:0000563)1.97705396
64Pachygyria (HP:0001302)1.96519859
65Chronic bronchitis (HP:0004469)1.95988667
66Abnormality of the lumbar spine (HP:0100712)1.94938441
67Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93816796
68Ulnar bowing (HP:0003031)1.93512111
69Duplicated collecting system (HP:0000081)1.91109438
70Renal salt wasting (HP:0000127)1.90684416
71Abnormal rod and cone electroretinograms (HP:0008323)1.89604227
72Type II diabetes mellitus (HP:0005978)1.89478351
73Unilateral renal agenesis (HP:0000122)1.88839563
74Retinitis pigmentosa (HP:0000510)1.88716049
75Abnormality of the ischium (HP:0003174)1.86394338
76Thyroiditis (HP:0100646)1.85993894
77Abnormality of B cell number (HP:0010975)1.82798495
78Prostate neoplasm (HP:0100787)1.82476319
79IgG deficiency (HP:0004315)1.81405318
80Broad toe (HP:0001837)1.77973116
81Abnormality of dentin (HP:0010299)1.77740036
82Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76849936
83Hypoplastic scapulae (HP:0000882)1.76849936
84Lip pit (HP:0100267)1.76301242
85Short 4th metacarpal (HP:0010044)1.74170480
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74170480
87Metaphyseal dysplasia (HP:0100255)1.72995414
88Thickened calvaria (HP:0002684)1.71623291
89Hypoproteinemia (HP:0003075)1.71006837
90Adactyly (HP:0009776)1.70721894
91Proximal placement of thumb (HP:0009623)1.70576930
92Blepharitis (HP:0000498)1.70120428
93Pancreatic cysts (HP:0001737)1.69935024
94Abnormality of male internal genitalia (HP:0000022)1.69643205
95Abnormality of the sella turcica (HP:0002679)1.68598787
96Fine hair (HP:0002213)1.68183696
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.66600651
98Limited elbow extension (HP:0001377)1.66162344
99Focal motor seizures (HP:0011153)1.65057937
100Abnormality of potassium homeostasis (HP:0011042)1.61223692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.81727818
2TAF14.59271038
3TXK3.51337804
4CASK2.65675826
5PIK3CG2.47647453
6VRK22.20403195
7MAP3K912.0461799
8PNCK1.74201713
9NLK1.71843559
10INSRR1.61470616
11LATS11.47408559
12ARAF1.46750732
13MAP3K131.43882350
14PASK1.42579270
15FRK1.33636269
16NUAK11.29162975
17ADRBK21.28922956
18SMG11.26969862
19MAP3K111.20561007
20DDR21.13535719
21GRK11.13150978
22NTRK21.07916342
23NEK10.95602004
24WNK30.93337782
25MAPKAPK50.93200854
26CDK80.91250351
27CDK90.86232959
28DAPK10.85985199
29AURKA0.84850490
30CHEK20.83729568
31MATK0.81256095
32MELK0.79231041
33MAP3K120.73303833
34GRK50.58558391
35ZAK0.53503447
36MAP4K10.52308829
37SGK20.51621401
38SIK20.49956896
39PAK10.49192193
40VRK10.47598178
41MAPK40.47285431
42OXSR10.45986227
43CAMKK10.45649387
44RPS6KA60.45183564
45CDK190.44083023
46DAPK20.43219487
47SIK30.41161637
48MAP2K10.39973984
49MOS0.39144381
50BMPR1B0.37852247
51MAP3K70.37545550
52SIK10.37333721
53NEK90.37061802
54RPS6KC10.36474231
55RPS6KL10.36474231
56TESK20.34798834
57PRKCG0.34589601
58TEC0.34394911
59KSR20.34084944
60TNIK0.33899366
61KDR0.33876735
62RPS6KB20.33167689
63PRKCH0.32293479
64BUB10.32076014
65SCYL20.32063793
66ITK0.31759616
67STK38L0.31328779
68KIT0.31073100
69TYRO30.30638239
70PRKG20.30215924
71IKBKE0.30088015
72MAPK130.26958795
73ADRBK10.26583126
74DAPK30.24705994
75AURKB0.24351382
76SGK2230.23772485
77SGK4940.23772485
78RPS6KB10.23634666
79CAMK1G0.22715120
80RPS6KA30.22117686
81CSNK1A1L0.21804602
82NEK20.21658385
83ACVR1B0.21604939
84PRKCB0.18510422
85FGR0.17690783
86CSF1R0.17387255
87BRAF0.16747975
88TAOK30.16546568
89CDK70.16122112
90PRKACA0.15128822
91GRK70.15116622
92PRKG10.14577044
93SGK30.14346688
94PRKCA0.13240592
95CSNK1G30.13191790
96GRK60.12128077
97MYLK0.11451799
98CSNK1G10.11393812
99LIMK10.11182233
100STK380.11047892

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.18122931
2One carbon pool by folate_Homo sapiens_hsa006703.72547144
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.24607924
4Phototransduction_Homo sapiens_hsa047443.14240050
5Nicotine addiction_Homo sapiens_hsa050332.70390033
6Primary immunodeficiency_Homo sapiens_hsa053402.66054285
7Basal transcription factors_Homo sapiens_hsa030222.59645269
8Taste transduction_Homo sapiens_hsa047422.51971546
9Olfactory transduction_Homo sapiens_hsa047402.47202147
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.31507657
11Morphine addiction_Homo sapiens_hsa050322.21111118
12Linoleic acid metabolism_Homo sapiens_hsa005911.94932178
13Fatty acid biosynthesis_Homo sapiens_hsa000611.92822486
14Ribosome_Homo sapiens_hsa030101.87808845
15GABAergic synapse_Homo sapiens_hsa047271.80742411
16Tryptophan metabolism_Homo sapiens_hsa003801.78492802
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75001538
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61850837
19ABC transporters_Homo sapiens_hsa020101.58328371
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.55281668
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51233085
22Butanoate metabolism_Homo sapiens_hsa006501.50271256
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43432680
24Ether lipid metabolism_Homo sapiens_hsa005651.33547853
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.32449530
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31717659
27Calcium signaling pathway_Homo sapiens_hsa040201.29366072
28Retinol metabolism_Homo sapiens_hsa008301.29089025
29Circadian entrainment_Homo sapiens_hsa047131.28192323
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.25382274
31Dorso-ventral axis formation_Homo sapiens_hsa043201.22307085
32Salivary secretion_Homo sapiens_hsa049701.22268487
33Basal cell carcinoma_Homo sapiens_hsa052171.20057863
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18466692
35Fat digestion and absorption_Homo sapiens_hsa049751.12314134
36Nitrogen metabolism_Homo sapiens_hsa009101.10767489
37Malaria_Homo sapiens_hsa051441.05588074
38Ovarian steroidogenesis_Homo sapiens_hsa049130.97425820
39Arachidonic acid metabolism_Homo sapiens_hsa005900.96204411
40Serotonergic synapse_Homo sapiens_hsa047260.96145700
41Pancreatic secretion_Homo sapiens_hsa049720.95144386
42Chemical carcinogenesis_Homo sapiens_hsa052040.95068397
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.94461427
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90989286
45Oxidative phosphorylation_Homo sapiens_hsa001900.87377899
46Glutamatergic synapse_Homo sapiens_hsa047240.87161288
47Proteasome_Homo sapiens_hsa030500.83848126
48Homologous recombination_Homo sapiens_hsa034400.82808174
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75299115
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74920818
51Oocyte meiosis_Homo sapiens_hsa041140.74846958
52Asthma_Homo sapiens_hsa053100.74682452
53Glycerolipid metabolism_Homo sapiens_hsa005610.73145837
54Graft-versus-host disease_Homo sapiens_hsa053320.72972447
55RNA polymerase_Homo sapiens_hsa030200.71561814
56Pyrimidine metabolism_Homo sapiens_hsa002400.69441714
57Sphingolipid metabolism_Homo sapiens_hsa006000.68682959
58Cardiac muscle contraction_Homo sapiens_hsa042600.67734132
59Cell cycle_Homo sapiens_hsa041100.66754895
60Hedgehog signaling pathway_Homo sapiens_hsa043400.66212173
61Selenocompound metabolism_Homo sapiens_hsa004500.64818096
62Thyroid cancer_Homo sapiens_hsa052160.61275290
63Caffeine metabolism_Homo sapiens_hsa002320.60146380
64Hematopoietic cell lineage_Homo sapiens_hsa046400.60047990
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58835260
66Insulin secretion_Homo sapiens_hsa049110.58833545
67Melanogenesis_Homo sapiens_hsa049160.57806147
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57749296
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56936681
70Systemic lupus erythematosus_Homo sapiens_hsa053220.55603229
71Autoimmune thyroid disease_Homo sapiens_hsa053200.54770805
72Purine metabolism_Homo sapiens_hsa002300.53905925
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53655942
74Cholinergic synapse_Homo sapiens_hsa047250.53359589
75Protein digestion and absorption_Homo sapiens_hsa049740.52785651
76Vitamin digestion and absorption_Homo sapiens_hsa049770.52388041
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51845202
78Allograft rejection_Homo sapiens_hsa053300.49568484
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49116768
80Huntingtons disease_Homo sapiens_hsa050160.48725443
81Type I diabetes mellitus_Homo sapiens_hsa049400.44403247
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44221007
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44174703
84Bile secretion_Homo sapiens_hsa049760.40267864
85Alzheimers disease_Homo sapiens_hsa050100.39839320
86Histidine metabolism_Homo sapiens_hsa003400.39708008
87T cell receptor signaling pathway_Homo sapiens_hsa046600.38489547
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36384997
89Parkinsons disease_Homo sapiens_hsa050120.35894333
90cAMP signaling pathway_Homo sapiens_hsa040240.34990115
91Rheumatoid arthritis_Homo sapiens_hsa053230.33830465
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33554418
93Gastric acid secretion_Homo sapiens_hsa049710.32681523
94Alcoholism_Homo sapiens_hsa050340.31637169
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30250065
96Bladder cancer_Homo sapiens_hsa052190.29241357
97Oxytocin signaling pathway_Homo sapiens_hsa049210.28652084
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28082731
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27400507
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25297791

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