DUX4L34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)8.31395949
2interkinetic nuclear migration (GO:0022027)7.30454638
3positive regulation of natural killer cell differentiation (GO:0032825)6.32574128
4positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.15014378
5iron-sulfur cluster assembly (GO:0016226)5.60566065
6metallo-sulfur cluster assembly (GO:0031163)5.60566065
7ubiquinone biosynthetic process (GO:0006744)5.17892539
8L-alpha-amino acid transmembrane transport (GO:1902475)5.06090846
9piRNA metabolic process (GO:0034587)4.77237079
10seminiferous tubule development (GO:0072520)4.76269997
11regulation of chemokine biosynthetic process (GO:0045073)4.66279441
12ubiquinone metabolic process (GO:0006743)4.47658359
13regulation of natural killer cell differentiation (GO:0032823)4.40679748
14tyrosine phosphorylation of STAT protein (GO:0007260)4.40184985
15cellular ketone body metabolic process (GO:0046950)4.30682842
16histone H3-K9 methylation (GO:0051567)4.23659764
17GPI anchor biosynthetic process (GO:0006506)4.18031702
18ribosomal small subunit assembly (GO:0000028)4.16599920
19quinone biosynthetic process (GO:1901663)4.15766431
20positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.08817200
21regulation of MHC class I biosynthetic process (GO:0045343)4.05241944
22Arp2/3 complex-mediated actin nucleation (GO:0034314)4.04469692
23negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.03706437
24regulation of activation of Janus kinase activity (GO:0010533)3.94297103
25negative regulation of type 2 immune response (GO:0002829)3.94250883
26GPI anchor metabolic process (GO:0006505)3.85871975
27forebrain morphogenesis (GO:0048853)3.84110390
28disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.79999694
29killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.79999694
30positive regulation of cell fate commitment (GO:0010455)3.79325343
31ketone body metabolic process (GO:1902224)3.78838201
32regulation of Golgi to plasma membrane protein transport (GO:0042996)3.75844517
33regulation of interleukin-8 biosynthetic process (GO:0045414)3.71477000
34pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.68233186
35UMP biosynthetic process (GO:0006222)3.68233186
36pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.68233186
37UMP metabolic process (GO:0046049)3.68233186
38actin nucleation (GO:0045010)3.61538734
39maternal behavior (GO:0042711)3.60728686
40rRNA methylation (GO:0031167)3.60678589
41regulation of interleukin-13 production (GO:0032656)3.60655517
42neutrophil mediated immunity (GO:0002446)3.58371521
43parental behavior (GO:0060746)3.58089323
44activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.54634905
45phosphorylated carbohydrate dephosphorylation (GO:0046838)3.42292354
46inositol phosphate dephosphorylation (GO:0046855)3.42292354
47positive regulation of natural killer cell activation (GO:0032816)3.37767861
48histone H3-K9 modification (GO:0061647)3.33542817
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.31369300
50poly(A)+ mRNA export from nucleus (GO:0016973)3.27107429
51ribosomal large subunit biogenesis (GO:0042273)3.24023732
52regulation of G0 to G1 transition (GO:0070316)3.23078282
53rRNA modification (GO:0000154)3.23012574
54pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.21011829
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17969727
56positive regulation of defense response to virus by host (GO:0002230)3.16863409
57nucleotide salvage (GO:0043173)3.16838280
58regulation of growth of symbiont in host (GO:0044126)3.14552300
59negative regulation of growth of symbiont in host (GO:0044130)3.14552300
60negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.14552300
61modulation of growth of symbiont involved in interaction with host (GO:0044144)3.14552300
62primitive streak formation (GO:0090009)3.09341410
63negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.04353102
64negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.03895504
65phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.97477072
66pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.96505159
67viral transcription (GO:0019083)2.95012441
68regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.94507431
69translational termination (GO:0006415)2.93787162
70inositol phosphate catabolic process (GO:0071545)2.93099075
71disruption of cells of other organism (GO:0044364)2.90331154
72killing of cells of other organism (GO:0031640)2.90331154
73negative regulation of chemokine production (GO:0032682)2.89695679
74positive regulation of B cell differentiation (GO:0045579)2.89564759
75neutrophil activation involved in immune response (GO:0002283)2.89298031
76mRNA cleavage (GO:0006379)2.87332587
77hepatocyte differentiation (GO:0070365)2.86904366
78regulation of B cell receptor signaling pathway (GO:0050855)2.85470515
79positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.84822762
80male meiosis I (GO:0007141)2.83070269
81definitive hemopoiesis (GO:0060216)2.82794304
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78786926
83regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.75759830
84glycolipid biosynthetic process (GO:0009247)2.75340695
85cellular response to reactive nitrogen species (GO:1902170)2.73741199
86induction of positive chemotaxis (GO:0050930)2.73618257
87positive regulation of meiosis (GO:0045836)2.71949357
88oocyte maturation (GO:0001556)2.70714004
89GDP-mannose metabolic process (GO:0019673)2.68312525
90RNA polyadenylation (GO:0043631)2.68002730
91mRNA polyadenylation (GO:0006378)2.67938709
92regulation of hypersensitivity (GO:0002883)2.67521987
93preassembly of GPI anchor in ER membrane (GO:0016254)2.66551737
94response to interferon-beta (GO:0035456)2.61653142
95meiosis I (GO:0007127)2.61064675
96Peyers patch development (GO:0048541)2.60879931
97mucosal-associated lymphoid tissue development (GO:0048537)2.60879931
98response to fungus (GO:0009620)2.60617425
99intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.57971083
100cytidine catabolic process (GO:0006216)2.57242904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.59925805
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.71259474
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.26640951
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.20100507
5VDR_22108803_ChIP-Seq_LS180_Human3.04849229
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31909358
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31278160
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16975662
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13693083
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.08034165
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01646359
12SCL_19346495_ChIP-Seq_HPC-7_Human2.01062098
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98708135
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94792499
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84775709
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84145685
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82684842
18FUS_26573619_Chip-Seq_HEK293_Human1.81455259
19UTX_26944678_Chip-Seq_JUKART_Human1.81014806
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74888388
21TP53_16413492_ChIP-PET_HCT116_Human1.72967988
22GATA3_26560356_Chip-Seq_TH2_Human1.72516181
23MYB_26560356_Chip-Seq_TH2_Human1.69793486
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69645764
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67214171
26GATA3_27048872_Chip-Seq_THYMUS_Human1.61893303
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61733140
28CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.61476065
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.55999224
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53702950
31AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49476832
32PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.47217161
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45769372
34RUNX_20019798_ChIP-Seq_JUKART_Human1.45456634
35NANOG_20526341_ChIP-Seq_ESCs_Human1.44546306
36TP53_22573176_ChIP-Seq_HFKS_Human1.43809590
37VDR_23849224_ChIP-Seq_CD4+_Human1.41724173
38RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.41393252
39CBP_20019798_ChIP-Seq_JUKART_Human1.39473850
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39473850
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.38679533
42CIITA_25753668_ChIP-Seq_RAJI_Human1.37909830
43NCOR_22424771_ChIP-Seq_293T_Human1.36075858
44CEBPB_22108803_ChIP-Seq_LS180_Human1.35628845
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34602309
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34571406
47SPI1_23547873_ChIP-Seq_NB4_Human1.32334532
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31951233
49VDR_24763502_ChIP-Seq_THP-1_Human1.28283655
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27112723
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26704359
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26004462
53GATA3_21867929_ChIP-Seq_TH1_Mouse1.25603527
54P300_27268052_Chip-Seq_Bcells_Human1.25399273
55HTT_18923047_ChIP-ChIP_STHdh_Human1.24339348
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23840435
57VDR_21846776_ChIP-Seq_THP-1_Human1.22610662
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22037543
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.21711348
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21711348
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19317775
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18949588
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18733014
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18315813
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16278976
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15495297
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15460504
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.14994319
69MYC_18940864_ChIP-ChIP_HL60_Human1.13096950
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12515977
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12515977
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12515977
73BCL6_27268052_Chip-Seq_Bcells_Human1.12121879
74ERG_20517297_ChIP-Seq_VCAP_Human1.11776383
75CDX2_22108803_ChIP-Seq_LS180_Human1.11296424
76BCAT_22108803_ChIP-Seq_LS180_Human1.11268973
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.10865464
78PHF8_20622854_ChIP-Seq_HELA_Human1.10748764
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10541860
80AR_20517297_ChIP-Seq_VCAP_Human1.10441370
81MYB_26560356_Chip-Seq_TH1_Human1.07926060
82E2F1_20622854_ChIP-Seq_HELA_Human1.07542299
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05655892
84GATA3_26560356_Chip-Seq_TH1_Human1.04740726
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04593892
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04440008
87MYC_19829295_ChIP-Seq_ESCs_Human1.03233009
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02205730
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01918940
90BCOR_27268052_Chip-Seq_Bcells_Human1.00736613
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00449664
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00173822
93P68_20966046_ChIP-Seq_HELA_Human0.99975839
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.99258863
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99197173
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99132322
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98679194
98ER_23166858_ChIP-Seq_MCF-7_Human0.98543774
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95553781
100SPI1_23127762_ChIP-Seq_K562_Human0.94161801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.25511764
2MP0000569_abnormal_digit_pigmentation5.01249179
3MP0005174_abnormal_tail_pigmentation4.33024511
4MP0006292_abnormal_olfactory_placode3.89282649
5MP0002163_abnormal_gland_morphology3.47805260
6MP0000372_irregular_coat_pigmentation3.17286658
7MP0000015_abnormal_ear_pigmentation2.91539547
8MP0010368_abnormal_lymphatic_system2.90208429
9MP0005397_hematopoietic_system_phenotyp2.49639721
10MP0001545_abnormal_hematopoietic_system2.49639721
11MP0001188_hyperpigmentation2.41111309
12MP0002132_abnormal_respiratory_system2.23421967
13MP0009764_decreased_sensitivity_to2.19579257
14MP0002822_catalepsy2.06808056
15MP0005084_abnormal_gallbladder_morpholo2.04240327
16MP0003172_abnormal_lysosome_physiology2.01001725
17MP0005645_abnormal_hypothalamus_physiol1.89648927
18MP0009785_altered_susceptibility_to1.87015735
19MP0002095_abnormal_skin_pigmentation1.72823677
20MP0010155_abnormal_intestine_physiology1.68758817
21MP0001986_abnormal_taste_sensitivity1.66346104
22MP0005379_endocrine/exocrine_gland_phen1.65612188
23MP0001800_abnormal_humoral_immune1.58355845
24MP0008058_abnormal_DNA_repair1.57121856
25MP0006082_CNS_inflammation1.55816041
26MP0005075_abnormal_melanosome_morpholog1.54015926
27MP0002148_abnormal_hypersensitivity_rea1.53385514
28MP0005671_abnormal_response_to1.52611910
29MP0000681_abnormal_thyroid_gland1.47700574
30MP0002928_abnormal_bile_duct1.46096883
31MP0002160_abnormal_reproductive_system1.44444325
32MP0009697_abnormal_copulation1.41576988
33MP0005025_abnormal_response_to1.41172446
34MP0003763_abnormal_thymus_physiology1.39443371
35MP0005464_abnormal_platelet_physiology1.37633424
36MP0004808_abnormal_hematopoietic_stem1.34873914
37MP0005167_abnormal_blood-brain_barrier1.28024116
38MP0005000_abnormal_immune_tolerance1.25910145
39MP0003436_decreased_susceptibility_to1.23648262
40MP0009765_abnormal_xenobiotic_induced1.23508226
41MP0002938_white_spotting1.21970469
42MP0002723_abnormal_immune_serum1.21108390
43MP0009384_cardiac_valve_regurgitation1.20201972
44MP0005389_reproductive_system_phenotype1.18079841
45MP0002398_abnormal_bone_marrow1.10928184
46MP0003136_yellow_coat_color1.09379658
47MP0003183_abnormal_peptide_metabolism1.09328296
48MP0002420_abnormal_adaptive_immunity1.09278388
49MP0008995_early_reproductive_senescence1.07734403
50MP0001819_abnormal_immune_cell1.05297996
51MP0004043_abnormal_pH_regulation1.02178155
52MP0005164_abnormal_response_to1.01898126
53MP0001879_abnormal_lymphatic_vessel1.01698446
54MP0001968_abnormal_touch/_nociception1.01147028
55MP0001845_abnormal_inflammatory_respons0.99399065
56MP0000716_abnormal_immune_system0.98642024
57MP0002419_abnormal_innate_immunity0.98168610
58MP0004484_altered_response_of0.96291297
59MP0008874_decreased_physiological_sensi0.95186351
60MP0002735_abnormal_chemical_nociception0.94538195
61MP0005551_abnormal_eye_electrophysiolog0.93779922
62MP0000703_abnormal_thymus_morphology0.93759993
63MP0006036_abnormal_mitochondrial_physio0.93728568
64MP0004947_skin_inflammation0.92566635
65MP0002722_abnormal_immune_system0.90925146
66MP0009763_increased_sensitivity_to0.88885152
67MP0008873_increased_physiological_sensi0.87776973
68MP0002733_abnormal_thermal_nociception0.86687629
69MP0002452_abnormal_antigen_presenting0.86004583
70MP0001929_abnormal_gametogenesis0.85515425
71MP0000689_abnormal_spleen_morphology0.81564689
72MP0004147_increased_porphyrin_level0.79688169
73MP0002009_preneoplasia0.79334240
74MP0006138_congestive_heart_failure0.78464706
75MP0003828_pulmonary_edema0.78397574
76MP0001835_abnormal_antigen_presentation0.78162895
77MP0005410_abnormal_fertilization0.76524591
78MP0008469_abnormal_protein_level0.76180894
79MP0002429_abnormal_blood_cell0.75778213
80MP0001485_abnormal_pinna_reflex0.74780864
81MP0003011_delayed_dark_adaptation0.74388740
82MP0004130_abnormal_muscle_cell0.74195497
83MP0001970_abnormal_pain_threshold0.74158822
84MP0008872_abnormal_physiological_respon0.73889789
85MP0005387_immune_system_phenotype0.73620790
86MP0001790_abnormal_immune_system0.73620790
87MP0005646_abnormal_pituitary_gland0.73010167
88MP0003787_abnormal_imprinting0.71044900
89MP0005367_renal/urinary_system_phenotyp0.69298651
90MP0000516_abnormal_urinary_system0.69298651
91MP0009333_abnormal_splenocyte_physiolog0.66744526
92MP0005503_abnormal_tendon_morphology0.66231580
93MP0002837_dystrophic_cardiac_calcinosis0.66213108
94MP0005670_abnormal_white_adipose0.65028893
95MP0003698_abnormal_male_reproductive0.64982248
96MP0004883_abnormal_blood_vessel0.63477410
97MP0002102_abnormal_ear_morphology0.63319156
98MP0003656_abnormal_erythrocyte_physiolo0.61432825
99MP0003123_paternal_imprinting0.60045197
100MP0003724_increased_susceptibility_to0.59368136

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)6.62605954
2B lymphocytopenia (HP:0010976)4.73229742
3Abnormality of B cell number (HP:0010975)4.54999064
4Eosinophilia (HP:0001880)3.91975389
5Acute hepatic failure (HP:0006554)3.50752304
6Granulocytopenia (HP:0001913)3.47443751
7Cerebellar dysplasia (HP:0007033)3.44319565
8Gingival bleeding (HP:0000225)3.42490666
9Spontaneous abortion (HP:0005268)3.31885066
10Type I transferrin isoform profile (HP:0003642)3.27240847
11Hypoplasia of the pons (HP:0012110)3.17620305
12Abnormality of eosinophils (HP:0001879)3.11970380
13Inflammation of the large intestine (HP:0002037)3.06356195
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.03367743
15Abnormal protein N-linked glycosylation (HP:0012347)3.03367743
16Abnormal protein glycosylation (HP:0012346)3.03367743
17Abnormal glycosylation (HP:0012345)3.03367743
18Autoimmune thrombocytopenia (HP:0001973)3.03165842
19Increased intramyocellular lipid droplets (HP:0012240)3.00718214
20T lymphocytopenia (HP:0005403)2.96360943
21Abnormality of T cell number (HP:0011839)2.94154778
22Gastrointestinal inflammation (HP:0004386)2.87284138
23Autoimmune hemolytic anemia (HP:0001890)2.86523662
24Type II lissencephaly (HP:0007260)2.85642226
25Gastrointestinal infarctions (HP:0005244)2.82173560
26Choroideremia (HP:0001139)2.81224059
27Renal cortical cysts (HP:0000803)2.80875856
28Fatigue (HP:0012378)2.72324512
29Tinnitus (HP:0000360)2.69419930
30Abnormality of the pons (HP:0007361)2.66917013
31Leukocytosis (HP:0001974)2.66669291
32Increased muscle lipid content (HP:0009058)2.66029281
33Agammaglobulinemia (HP:0004432)2.65780027
34Pancreatic fibrosis (HP:0100732)2.64867340
35True hermaphroditism (HP:0010459)2.64617885
36Severe visual impairment (HP:0001141)2.59920613
37Reduced antithrombin III activity (HP:0001976)2.59875396
38Febrile seizures (HP:0002373)2.52437734
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.51177600
40Hypergammaglobulinemia (HP:0010702)2.51100812
41Diastasis recti (HP:0001540)2.47403526
42Pancreatic cysts (HP:0001737)2.46574536
43Palpebral edema (HP:0100540)2.42816562
44Congenital primary aphakia (HP:0007707)2.40986411
45Panhypogammaglobulinemia (HP:0003139)2.40009296
46Colitis (HP:0002583)2.38584328
47Exertional dyspnea (HP:0002875)2.35358112
48Brushfield spots (HP:0001088)2.33316713
49Gait imbalance (HP:0002141)2.31842578
50Neurodegeneration (HP:0002180)2.30906883
51Abnormal hemoglobin (HP:0011902)2.24122599
52Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23301259
53Retinal atrophy (HP:0001105)2.22648820
54Short tibia (HP:0005736)2.21283768
55Respiratory difficulties (HP:0002880)2.21280567
56Spontaneous hematomas (HP:0007420)2.21214442
57Concave nail (HP:0001598)2.18357391
58Nephrogenic diabetes insipidus (HP:0009806)2.17022936
59Abnormality of T cells (HP:0002843)2.13064744
60Medial flaring of the eyebrow (HP:0010747)2.12810483
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.10959448
62Nasal polyposis (HP:0100582)2.09460733
63Spastic paraparesis (HP:0002313)2.07875733
64Encephalitis (HP:0002383)2.07544546
65Epistaxis (HP:0000421)2.02445394
66Preauricular pit (HP:0004467)2.01019605
67Periauricular skin pits (HP:0100277)2.01019605
68Ketoacidosis (HP:0001993)1.99949042
69Chest pain (HP:0100749)1.99167203
70Stenosis of the external auditory canal (HP:0000402)1.98334082
71Poor coordination (HP:0002370)1.97232269
72Acute lymphatic leukemia (HP:0006721)1.95897204
73Retinal dysplasia (HP:0007973)1.95086071
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95061731
75IgG deficiency (HP:0004315)1.94992259
76Albinism (HP:0001022)1.92833074
77Brittle hair (HP:0002299)1.92305394
78Decreased central vision (HP:0007663)1.92001837
79Abnormality of alanine metabolism (HP:0010916)1.91490530
80Hyperalaninemia (HP:0003348)1.91490530
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91490530
82Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86470909
83Hematochezia (HP:0002573)1.85428306
84Absent speech (HP:0001344)1.84184605
85Redundant skin (HP:0001582)1.83846162
86Increased IgM level (HP:0003496)1.83673936
87Sensorimotor neuropathy (HP:0007141)1.83240086
88Tachypnea (HP:0002789)1.81964111
89Dyschromatopsia (HP:0007641)1.80863383
90Recurrent bacterial skin infections (HP:0005406)1.80662077
91Elevated erythrocyte sedimentation rate (HP:0003565)1.80423835
92Hepatocellular necrosis (HP:0001404)1.79963801
93Abnormality of fatty-acid metabolism (HP:0004359)1.77898425
94Obstructive lung disease (HP:0006536)1.77750613
95Chronic obstructive pulmonary disease (HP:0006510)1.77750613
96Cystic liver disease (HP:0006706)1.76852760
97Asthma (HP:0002099)1.75690810
98Severe combined immunodeficiency (HP:0004430)1.75590530
99Abnormality of lateral ventricle (HP:0030047)1.73758111
100Recurrent abscess formation (HP:0002722)1.72642689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.59604494
2TIE15.13276204
3TEC3.07208712
4RIPK43.02248272
5STK242.96503166
6BMPR22.83882089
7ADRBK22.77772145
8MAP3K52.56625376
9MAP3K132.45059327
10STK38L2.38629011
11RPS6KA42.28031309
12TESK22.15268650
13VRK12.10858895
14TLK12.03184653
15KDR1.90636911
16VRK21.76366563
17PIM21.75662388
18IKBKB1.72604766
19JAK31.70228407
20KIT1.67867335
21TAOK31.65052496
22ITK1.56912090
23MELK1.41405098
24GRK71.39126960
25TBK11.33412619
26IKBKE1.26747542
27PIM11.25594692
28BRSK21.19709891
29PRKCQ1.16604260
30EIF2AK31.10904728
31RPS6KA51.06311277
32STK31.05613054
33BMPR1B0.98747722
34CAMKK20.98442413
35NTRK20.98173534
36MAP3K140.97461310
37TYK20.96753906
38NLK0.96622275
39GRK10.94143359
40MATK0.90985458
41DAPK30.89447841
42BTK0.89229568
43DAPK10.88867593
44MAP2K70.85387090
45TXK0.83450954
46JAK10.77886005
47ADRBK10.77814603
48TRIM280.76954634
49BCKDK0.76453652
50JAK20.75730560
51PDK20.74283900
52FLT30.73334735
53SIK30.67772253
54CSNK1A10.66589269
55GSK3A0.64374848
56SYK0.63801935
57CSNK1G10.63598596
58FRK0.63456614
59CHUK0.62775223
60NUAK10.60464839
61SCYL20.59558849
62FES0.58428143
63LCK0.56517884
64DAPK20.55755871
65BCR0.55669031
66INSRR0.48996850
67DYRK1A0.48446056
68ABL10.45894077
69MAP3K120.44136910
70CHEK20.43815795
71CDK30.43776577
72PIK3CG0.41796251
73PRKCH0.41586318
74LYN0.39223504
75GRK50.38609817
76MAP3K70.38424269
77RPS6KA60.37133168
78TGFBR10.35857281
79PDK10.35644517
80RPS6KL10.35364624
81RPS6KC10.35364624
82RPS6KB10.34745269
83CAMK2B0.34628225
84NEK20.33963879
85RPS6KB20.33160931
86AURKA0.33142206
87GRK60.32386420
88PRKCA0.31364584
89WNK30.27060525
90PKN10.26692625
91CDK60.26477305
92PDPK10.25311490
93MAP4K20.24803213
94CAMK10.24379563
95ALK0.24173359
96EIF2AK20.23902031
97HCK0.23865999
98CAMK2D0.23403793
99IGF1R0.22088051
100TAF10.21477517

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.32371794
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.19652650
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.61089430
4Ribosome_Homo sapiens_hsa030103.20882407
5Butanoate metabolism_Homo sapiens_hsa006503.05771963
6Homologous recombination_Homo sapiens_hsa034402.74888242
7Basal transcription factors_Homo sapiens_hsa030222.42256717
8Regulation of autophagy_Homo sapiens_hsa041402.19966236
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10978029
10Renin-angiotensin system_Homo sapiens_hsa046141.98686129
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97637669
12Sulfur metabolism_Homo sapiens_hsa009201.93353807
13Phototransduction_Homo sapiens_hsa047441.87954958
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73319621
15Hematopoietic cell lineage_Homo sapiens_hsa046401.63478753
16ABC transporters_Homo sapiens_hsa020101.60940897
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.44280313
18Oxidative phosphorylation_Homo sapiens_hsa001901.42551971
19Rheumatoid arthritis_Homo sapiens_hsa053231.40916406
20beta-Alanine metabolism_Homo sapiens_hsa004101.40313899
21Nitrogen metabolism_Homo sapiens_hsa009101.36871570
22Peroxisome_Homo sapiens_hsa041461.34849072
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30570471
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.29566448
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.28989744
26Asthma_Homo sapiens_hsa053101.21679360
27Collecting duct acid secretion_Homo sapiens_hsa049661.21294712
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20385804
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20351868
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19631183
31Olfactory transduction_Homo sapiens_hsa047401.18553448
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.17438100
33Retinol metabolism_Homo sapiens_hsa008301.16678255
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16210321
35Arachidonic acid metabolism_Homo sapiens_hsa005901.10864128
36Proteasome_Homo sapiens_hsa030501.04871550
37Pancreatic secretion_Homo sapiens_hsa049721.04305722
38Phenylalanine metabolism_Homo sapiens_hsa003601.01484932
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99367934
40Antigen processing and presentation_Homo sapiens_hsa046120.98096334
41Fanconi anemia pathway_Homo sapiens_hsa034600.95212379
42Linoleic acid metabolism_Homo sapiens_hsa005910.94644113
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93214366
44Parkinsons disease_Homo sapiens_hsa050120.91660764
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91498045
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91419868
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88490582
48Autoimmune thyroid disease_Homo sapiens_hsa053200.86585009
49Herpes simplex infection_Homo sapiens_hsa051680.86101417
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84438674
51Graft-versus-host disease_Homo sapiens_hsa053320.83048422
52African trypanosomiasis_Homo sapiens_hsa051430.80853222
53Starch and sucrose metabolism_Homo sapiens_hsa005000.78444521
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77912245
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.77191671
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.75970398
57mRNA surveillance pathway_Homo sapiens_hsa030150.75945190
58Systemic lupus erythematosus_Homo sapiens_hsa053220.74957037
59Alzheimers disease_Homo sapiens_hsa050100.74903019
60Huntingtons disease_Homo sapiens_hsa050160.73893375
61Allograft rejection_Homo sapiens_hsa053300.73045294
62Shigellosis_Homo sapiens_hsa051310.70453825
63Type I diabetes mellitus_Homo sapiens_hsa049400.69888931
64Nucleotide excision repair_Homo sapiens_hsa034200.67176718
65p53 signaling pathway_Homo sapiens_hsa041150.65827087
66Histidine metabolism_Homo sapiens_hsa003400.65029387
67RNA degradation_Homo sapiens_hsa030180.64361692
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64277948
69Other glycan degradation_Homo sapiens_hsa005110.62747721
70Fat digestion and absorption_Homo sapiens_hsa049750.61095460
71Tryptophan metabolism_Homo sapiens_hsa003800.60738345
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60493490
73Chemical carcinogenesis_Homo sapiens_hsa052040.58642332
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57094080
75Salivary secretion_Homo sapiens_hsa049700.56030130
76Phagosome_Homo sapiens_hsa041450.56028126
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55609379
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54192609
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52784068
80Nicotine addiction_Homo sapiens_hsa050330.52444425
81Taste transduction_Homo sapiens_hsa047420.51843222
82Protein digestion and absorption_Homo sapiens_hsa049740.51377082
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51152577
84Galactose metabolism_Homo sapiens_hsa000520.48959251
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48441630
86Measles_Homo sapiens_hsa051620.46890461
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44285464
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43841522
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42312928
90Staphylococcus aureus infection_Homo sapiens_hsa051500.42257011
91Leishmaniasis_Homo sapiens_hsa051400.40691835
92Tyrosine metabolism_Homo sapiens_hsa003500.39052020
93Fatty acid elongation_Homo sapiens_hsa000620.38974055
94Lysine degradation_Homo sapiens_hsa003100.38875152
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38718392
96Arginine and proline metabolism_Homo sapiens_hsa003300.38475179
97Selenocompound metabolism_Homo sapiens_hsa004500.36353078
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.36255292
99Fatty acid biosynthesis_Homo sapiens_hsa000610.35936348
100Metabolic pathways_Homo sapiens_hsa011000.35382559

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