DUX4L50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.09898371
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.09898371
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.09898371
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.09898371
5modulation by symbiont of host immune response (GO:0052553)6.09898371
6positive regulation by symbiont of host defense response (GO:0052509)6.09898371
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.52202808
8regulation of B cell receptor signaling pathway (GO:0050855)5.45750231
9positive regulation of gamma-delta T cell activation (GO:0046645)5.31219713
10negative regulation of cell killing (GO:0031342)5.21927368
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.21927368
12antigen processing and presentation of endogenous antigen (GO:0019883)4.88823197
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.75937764
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68035484
15neutrophil activation involved in immune response (GO:0002283)4.59360598
16macrophage activation involved in immune response (GO:0002281)4.59026268
17B cell receptor signaling pathway (GO:0050853)4.57396842
18detection of other organism (GO:0098543)4.43541953
19detection of bacterium (GO:0016045)4.36847017
20immunoglobulin mediated immune response (GO:0016064)4.29952984
21response to host immune response (GO:0052572)4.26548722
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.26548722
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25560888
24response to peptidoglycan (GO:0032494)4.24263636
25type I interferon signaling pathway (GO:0060337)4.03198164
26cellular response to type I interferon (GO:0071357)4.03198164
27response to type I interferon (GO:0034340)4.01567759
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00723957
29positive regulation of B cell differentiation (GO:0045579)3.97694182
30microglial cell activation (GO:0001774)3.96426116
31regulation of B cell differentiation (GO:0045577)3.93172936
32detection of molecule of bacterial origin (GO:0032490)3.91424890
33negative regulation of interleukin-12 production (GO:0032695)3.91224175
34detection of external biotic stimulus (GO:0098581)3.89182823
35respiratory burst (GO:0045730)3.86188652
36response to host (GO:0075136)3.84846748
37response to host defenses (GO:0052200)3.84846748
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.84846748
39response to interleukin-15 (GO:0070672)3.84698697
40DNA deamination (GO:0045006)3.82958156
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.80461020
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.79072911
43cellular extravasation (GO:0045123)3.73908382
44regulation of gamma-delta T cell activation (GO:0046643)3.69449499
45cytidine deamination (GO:0009972)3.65225442
46cytidine metabolic process (GO:0046087)3.65225442
47cytidine catabolic process (GO:0006216)3.65225442
48negative regulation of type 2 immune response (GO:0002829)3.64909355
49leukocyte aggregation (GO:0070486)3.64686101
50cellular response to interleukin-15 (GO:0071350)3.57640153
51myeloid cell activation involved in immune response (GO:0002275)3.57586590
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.56363828
53neutrophil activation (GO:0042119)3.55772379
54regulation of interferon-beta biosynthetic process (GO:0045357)3.51557593
55negative regulation of leukocyte mediated immunity (GO:0002704)3.49378009
56B cell mediated immunity (GO:0019724)3.45499841
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39147932
58negative regulation of B cell apoptotic process (GO:0002903)3.38730468
59detection of biotic stimulus (GO:0009595)3.37721730
60positive thymic T cell selection (GO:0045059)3.36741982
61pyrimidine ribonucleoside catabolic process (GO:0046133)3.36438768
62neutrophil mediated immunity (GO:0002446)3.35665256
63negative regulation of T cell mediated immunity (GO:0002710)3.35548297
64negative regulation of phagocytosis (GO:0050765)3.32859734
65regulation of interleukin-6 biosynthetic process (GO:0045408)3.30287038
66regulation of MHC class I biosynthetic process (GO:0045343)3.22791231
67negative thymic T cell selection (GO:0045060)3.22713388
68interferon-gamma-mediated signaling pathway (GO:0060333)3.21829029
69macrophage activation (GO:0042116)3.21404831
70regulation of mast cell activation (GO:0033003)3.15934177
71regulation of mast cell degranulation (GO:0043304)3.15646867
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12936732
73regulation of B cell apoptotic process (GO:0002902)3.12626703
74mature B cell differentiation involved in immune response (GO:0002313)3.11699794
75defense response to protozoan (GO:0042832)3.11317260
76chaperone mediated protein folding requiring cofactor (GO:0051085)3.09418650
77T cell migration (GO:0072678)3.08515925
78regulation of antigen processing and presentation (GO:0002577)3.08057098
79granulocyte activation (GO:0036230)3.07264276
80regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04401983
81negative T cell selection (GO:0043383)3.03950065
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03020409
83regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99974635
84positive T cell selection (GO:0043368)2.99745127
85negative regulation of T-helper cell differentiation (GO:0045623)2.99343506
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99343506
87positive regulation of interferon-alpha production (GO:0032727)2.99237587
88negative regulation of interleukin-6 production (GO:0032715)2.97446702
89regulation of gamma-delta T cell differentiation (GO:0045586)2.96855625
90germinal center formation (GO:0002467)2.95313650
91regulation of mast cell activation involved in immune response (GO:0033006)2.94821524
92response to interferon-beta (GO:0035456)2.93052413
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.92766000
94negative regulation of interleukin-1 production (GO:0032692)2.91358524
95response to protozoan (GO:0001562)2.91346403
96T cell selection (GO:0045058)2.90523211
97leukocyte degranulation (GO:0043299)2.90317433
98positive regulation of mast cell activation (GO:0033005)2.82288895
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80891465
100thymic T cell selection (GO:0045061)2.79863564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.87241746
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.84845222
3VDR_21846776_ChIP-Seq_THP-1_Human3.80478866
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.74368711
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.48400316
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29801044
7VDR_24763502_ChIP-Seq_THP-1_Human3.19299354
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.07072031
9MYC_22102868_ChIP-Seq_BL_Human3.02536823
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01407433
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92691443
12SPI1_23547873_ChIP-Seq_NB4_Human2.84858520
13SCL_19346495_ChIP-Seq_HPC-7_Human2.73356527
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.68855576
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68643646
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66242081
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61148279
18MYB_26560356_Chip-Seq_TH2_Human2.58816994
19RUNX_20019798_ChIP-Seq_JUKART_Human2.53281489
20MAF_26560356_Chip-Seq_TH1_Human2.52767215
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.50370851
22UTX_26944678_Chip-Seq_JUKART_Human2.47403779
23SPI1_23127762_ChIP-Seq_K562_Human2.43541776
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37162727
25MYB_26560356_Chip-Seq_TH1_Human2.20105468
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.15147267
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14863347
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13194785
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.05709304
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01617524
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00231865
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97753299
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.93744452
34MAF_26560356_Chip-Seq_TH2_Human1.93320679
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87880932
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87327380
37TCF7_22412390_ChIP-Seq_EML_Mouse1.84128035
38GATA3_27048872_Chip-Seq_THYMUS_Human1.81628907
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71822802
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70874148
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67878278
42BCL6_27268052_Chip-Seq_Bcells_Human1.65972647
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64108335
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63023690
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61509300
46KDM2B_26808549_Chip-Seq_DND41_Human1.59736676
47CIITA_25753668_ChIP-Seq_RAJI_Human1.56225771
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.55379360
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.54628873
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50430022
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48963650
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48154622
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46843651
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45266995
55VDR_24787735_ChIP-Seq_THP-1_Human1.43895144
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41221908
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39946587
58LXR_22292898_ChIP-Seq_THP-1_Human1.35001572
59BCOR_27268052_Chip-Seq_Bcells_Human1.34852241
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31638838
61GATA3_26560356_Chip-Seq_TH2_Human1.30865808
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30647241
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30578979
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29030935
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26908424
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25927131
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24798227
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.24589328
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24558446
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24100197
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23794366
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23020728
73RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20628508
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20263858
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20096204
76GATA1_19941826_ChIP-Seq_K562_Human1.19485086
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18686966
78P300_27268052_Chip-Seq_Bcells_Human1.16551220
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.15817605
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15309328
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14704633
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14191746
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10491924
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10417678
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09728966
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09461576
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.08881763
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05344711
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02745301
90DROSHA_22980978_ChIP-Seq_HELA_Human1.01354683
91P68_20966046_ChIP-Seq_HELA_Human1.01117448
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99800348
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99124952
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95516531
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93091487
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92695428
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92358035
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90983044
99NCOR1_26117541_ChIP-Seq_K562_Human0.90762766
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89741279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.94818506
2MP0003436_decreased_susceptibility_to3.93316392
3MP0003724_increased_susceptibility_to3.68576910
4MP0000685_abnormal_immune_system3.58754900
5MP0001800_abnormal_humoral_immune3.12981501
6MP0005451_abnormal_body_composition3.03691683
7MP0005671_abnormal_response_to2.98296085
8MP0002419_abnormal_innate_immunity2.96992419
9MP0005000_abnormal_immune_tolerance2.95593545
10MP0005387_immune_system_phenotype2.95292343
11MP0001790_abnormal_immune_system2.95292343
12MP0003303_peritoneal_inflammation2.90481055
13MP0009278_abnormal_bone_marrow2.87075811
14MP0005025_abnormal_response_to2.85953448
15MP0002396_abnormal_hematopoietic_system2.76179497
16MP0002723_abnormal_immune_serum2.70204095
17MP0002420_abnormal_adaptive_immunity2.70151650
18MP0001819_abnormal_immune_cell2.66291661
19MP0009785_altered_susceptibility_to2.65500149
20MP0002452_abnormal_antigen_presenting2.56597612
21MP0001545_abnormal_hematopoietic_system2.54869154
22MP0005397_hematopoietic_system_phenotyp2.54869154
23MP0008260_abnormal_autophagy2.42615876
24MP0003763_abnormal_thymus_physiology2.31135919
25MP0005464_abnormal_platelet_physiology2.24175690
26MP0002398_abnormal_bone_marrow2.21849354
27MP0000716_abnormal_immune_system2.10763474
28MP0002148_abnormal_hypersensitivity_rea2.05745075
29MP0003183_abnormal_peptide_metabolism1.93193686
30MP0000465_gastrointestinal_hemorrhage1.91592168
31MP0002405_respiratory_system_inflammati1.89876015
32MP0002722_abnormal_immune_system1.87570447
33MP0000689_abnormal_spleen_morphology1.84887327
34MP0002429_abnormal_blood_cell1.71430936
35MP0001533_abnormal_skeleton_physiology1.67440895
36MP0006082_CNS_inflammation1.65364392
37MP0005645_abnormal_hypothalamus_physiol1.63044950
38MP0001845_abnormal_inflammatory_respons1.61876768
39MP0003866_abnormal_defecation1.56588297
40MP0003300_gastrointestinal_ulcer1.54979562
41MP0010155_abnormal_intestine_physiology1.54956768
42MP0009764_decreased_sensitivity_to1.53973856
43MP0000703_abnormal_thymus_morphology1.52917982
44MP0005310_abnormal_salivary_gland1.49128063
45MP0005075_abnormal_melanosome_morpholog1.43040504
46MP0003191_abnormal_cellular_cholesterol1.41450272
47MP0003172_abnormal_lysosome_physiology1.38516904
48MP0001873_stomach_inflammation1.34829287
49MP0002166_altered_tumor_susceptibility1.34280633
50MP0004947_skin_inflammation1.27301284
51MP0002132_abnormal_respiratory_system1.26303054
52MP0003828_pulmonary_edema1.24714760
53MP0001986_abnormal_taste_sensitivity1.22699213
54MP0002822_catalepsy1.22366910
55MP0004381_abnormal_hair_follicle1.21436810
56MP0008469_abnormal_protein_level1.19920286
57MP0000858_altered_metastatic_potential1.16744413
58MP0009333_abnormal_splenocyte_physiolog1.12194989
59MP0000015_abnormal_ear_pigmentation1.07032224
60MP0003252_abnormal_bile_duct1.04580141
61MP0004808_abnormal_hematopoietic_stem1.03430055
62MP0000569_abnormal_digit_pigmentation0.94306090
63MP0000490_abnormal_crypts_of0.93541464
64MP0002006_tumorigenesis0.92463980
65MP0009765_abnormal_xenobiotic_induced0.88552006
66MP0008874_decreased_physiological_sensi0.86348215
67MP0006035_abnormal_mitochondrial_morpho0.83256458
68MP0004883_abnormal_blood_vessel0.82762171
69MP0002019_abnormal_tumor_incidence0.81224948
70MP0008873_increased_physiological_sensi0.78264719
71MP0009763_increased_sensitivity_to0.76611696
72MP0001663_abnormal_digestive_system0.75422496
73MP0003075_altered_response_to0.72250882
74MP0002277_abnormal_respiratory_mucosa0.67577692
75MP0001851_eye_inflammation0.66799056
76MP0005084_abnormal_gallbladder_morpholo0.63755095
77MP0002693_abnormal_pancreas_physiology0.60457782
78MP0002653_abnormal_ependyma_morphology0.56486785
79MP0008961_abnormal_basal_metabolism0.56093746
80MP0005166_decreased_susceptibility_to0.54753330
81MP0005390_skeleton_phenotype0.54530222
82MP0005164_abnormal_response_to0.51872836
83MP0000604_amyloidosis0.48280279
84MP0008872_abnormal_physiological_respon0.47878421
85MP0003806_abnormal_nucleotide_metabolis0.47607333
86MP0002998_abnormal_bone_remodeling0.46507965
87MP0000470_abnormal_stomach_morphology0.42302366
88MP0003221_abnormal_cardiomyocyte_apopto0.42213402
89MP0005535_abnormal_body_temperature0.42162925
90MP0002928_abnormal_bile_duct0.39970504
91MP0005367_renal/urinary_system_phenotyp0.39387585
92MP0000516_abnormal_urinary_system0.39387585
93MP0008004_abnormal_stomach_pH0.38561363
94MP0005621_abnormal_cell_physiology0.38434419
95MP0003638_abnormal_response/metabolism_0.38383815
96MP0001968_abnormal_touch/_nociception0.37879804
97MP0001853_heart_inflammation0.37475262
98MP0003011_delayed_dark_adaptation0.37104848
99MP0004742_abnormal_vestibular_system0.37006041
100MP0000371_diluted_coat_color0.36960057

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.54636689
2Elevated erythrocyte sedimentation rate (HP:0003565)5.41210337
3Myositis (HP:0100614)5.39151094
4Eczematoid dermatitis (HP:0000976)5.01186602
5Recurrent bacterial skin infections (HP:0005406)4.99375820
6Agammaglobulinemia (HP:0004432)4.71503292
7Meningitis (HP:0001287)4.63192230
8Recurrent fungal infections (HP:0002841)4.60215707
9Stomatitis (HP:0010280)4.59896594
10Obstructive lung disease (HP:0006536)4.55150984
11Chronic obstructive pulmonary disease (HP:0006510)4.55150984
12Mediastinal lymphadenopathy (HP:0100721)4.53831001
13Orchitis (HP:0100796)4.51467295
14Chronic mucocutaneous candidiasis (HP:0002728)4.47475547
15Recurrent cutaneous fungal infections (HP:0011370)4.47475547
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.42720408
17Retrobulbar optic neuritis (HP:0100654)4.26019259
18Optic neuritis (HP:0100653)4.26019259
19Abnormality of macrophages (HP:0004311)4.25126810
20Increased IgE level (HP:0003212)4.21123127
21Encephalitis (HP:0002383)3.92779187
22Cellulitis (HP:0100658)3.89552430
23Recurrent skin infections (HP:0001581)3.86995185
24Panhypogammaglobulinemia (HP:0003139)3.68989313
25Recurrent gram-negative bacterial infections (HP:0005420)3.62281262
26Vasculitis (HP:0002633)3.45940405
27Gastrointestinal inflammation (HP:0004386)3.45807012
28Inflammation of the large intestine (HP:0002037)3.39841072
29Urticaria (HP:0001025)3.36751288
30Chest pain (HP:0100749)3.36395676
31Gastrointestinal infarctions (HP:0005244)3.34235214
32Colitis (HP:0002583)3.30238638
33Prolonged bleeding time (HP:0003010)3.29212872
34Hypochromic microcytic anemia (HP:0004840)3.28719289
35B lymphocytopenia (HP:0010976)3.17494444
36Recurrent viral infections (HP:0004429)3.15750373
37Keratoconjunctivitis (HP:0001096)3.13823735
38Keratoconjunctivitis sicca (HP:0001097)3.04725002
39Abnormality of B cell number (HP:0010975)3.04192418
40Gingivitis (HP:0000230)2.94985120
41Sepsis (HP:0100806)2.94184202
42Recurrent sinusitis (HP:0011108)2.93661249
43Osteomyelitis (HP:0002754)2.92211720
44IgM deficiency (HP:0002850)2.87938957
45Granulocytopenia (HP:0001913)2.83150003
46Abnormality of T cell physiology (HP:0011840)2.83011106
47Arterial thrombosis (HP:0004420)2.79845569
48Episodic fever (HP:0001954)2.79203120
49Lymphopenia (HP:0001888)2.76834469
50Hypergammaglobulinemia (HP:0010702)2.74402675
51Epistaxis (HP:0000421)2.72628529
52Gastrointestinal stroma tumor (HP:0100723)2.66046410
53Hypochromic anemia (HP:0001931)2.64949100
54Leukocytosis (HP:0001974)2.64779726
55Recurrent pneumonia (HP:0006532)2.53860954
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.53552476
57Gingival bleeding (HP:0000225)2.51299448
58Hemoptysis (HP:0002105)2.49589891
59Recurrent lower respiratory tract infections (HP:0002783)2.44981828
60Spontaneous hematomas (HP:0007420)2.43735489
61Chronic otitis media (HP:0000389)2.41753935
62Viral hepatitis (HP:0006562)2.40318916
63Acute hepatic failure (HP:0006554)2.39527879
64Abnormality of T cells (HP:0002843)2.39478512
65Petechiae (HP:0000967)2.37416363
66Thrombocytosis (HP:0001894)2.36387656
67Pulmonary infiltrates (HP:0002113)2.34174364
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33823704
69Prostate neoplasm (HP:0100787)2.33480408
70Skin rash (HP:0000988)2.30960757
71Anorexia (HP:0002039)2.30433105
72Abnormality of the pleura (HP:0002103)2.29392261
73Papilloma (HP:0012740)2.28381737
74Verrucae (HP:0200043)2.28381737
75Hypertensive crisis (HP:0100735)2.26050208
76Abnormality of the prostate (HP:0008775)2.24634879
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.24595975
78Keratitis (HP:0000491)2.22024119
79Peritonitis (HP:0002586)2.21005196
80Skin ulcer (HP:0200042)2.19397340
81Autoimmune hemolytic anemia (HP:0001890)2.16592450
82Eosinophilia (HP:0001880)2.16132907
83Abnormality of the peritoneum (HP:0002585)2.13505287
84Slow saccadic eye movements (HP:0000514)2.13241559
85Loss of speech (HP:0002371)2.11121080
86IgG deficiency (HP:0004315)2.07750978
87Abnormality of the endocardium (HP:0004306)2.01985321
88Increased IgM level (HP:0003496)2.01924655
89Pustule (HP:0200039)1.99457336
90Acne (HP:0001061)1.92796037
91Autoimmune thrombocytopenia (HP:0001973)1.92657805
92Microcytic anemia (HP:0001935)1.92189750
93Pulmonary embolism (HP:0002204)1.90681827
94Recurrent bronchitis (HP:0002837)1.90644640
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.89125409
96Purpura (HP:0000979)1.88855553
97Gangrene (HP:0100758)1.83758153
98Severe visual impairment (HP:0001141)1.83735423
99Vertigo (HP:0002321)1.83407083
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80945827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.83659198
2RIPK44.59465369
3GRK63.05616312
4BCKDK2.95544349
5TESK22.90642316
6KIT2.85930160
7BLK2.72641656
8TNK22.54548788
9CDK192.40771947
10ERN12.33607425
11TAOK32.30597738
12IRAK42.24024182
13MAP3K112.13507122
14MAP2K32.04149805
15SYK1.95063487
16PRPF4B1.90043998
17TAOK11.89016751
18BTK1.87542680
19JAK31.85807301
20TYK21.85331033
21VRK21.84676992
22CSF1R1.81215359
23SMG11.75234203
24SIK21.75160959
25FES1.74379283
26CSK1.57964385
27PIM21.56563657
28TBK11.53124147
29LYN1.49484488
30KDR1.47319397
31SCYL21.46681943
32SIK31.27911395
33TAOK21.23614772
34IKBKE1.22849757
35MAP3K31.22383247
36HCK1.21919964
37MAP3K141.13888747
38MATK1.11653142
39LCK1.06578793
40FGR1.04457872
41IKBKB1.01494026
42MAP3K10.99823410
43JAK20.99163034
44TEC0.96059470
45DYRK1B0.94159603
46PRKD20.87477018
47MAP3K130.86264201
48TXK0.83176973
49HIPK20.82749068
50ZAP700.81964570
51BMPR20.76823575
52PIK3CG0.76369356
53PTK2B0.73817102
54JAK10.73781723
55ITK0.73033462
56MAP3K70.72548976
57MAP3K50.68577985
58FLT30.67000529
59MARK20.66236944
60TAF10.65789584
61PDK10.64033901
62NUAK10.63469291
63PRKCQ0.61445461
64GRK50.59754767
65EPHB10.59629819
66OXSR10.59125859
67TESK10.58358141
68PIM10.56755063
69IRAK10.55565151
70YES10.50694677
71KSR20.49724895
72FYN0.47844008
73FRK0.46105633
74RAF10.45582726
75MARK30.43578207
76PRKCH0.43558346
77DAPK10.42531732
78NME20.42111431
79ZAK0.42035283
80DYRK30.40625744
81VRK10.36078745
82MAPKAPK20.35728240
83TRIB30.33240300
84CCNB10.32583736
85MAP3K60.32257177
86ARAF0.30762814
87PDPK10.27463356
88MAP3K20.27340549
89MAP4K20.26731321
90PRKCD0.26481664
91MAPK70.26395323
92STK100.24672773
93PRKCZ0.24031955
94MAPK40.23613056
95LRRK20.22956933
96ABL10.22128015
97IRAK20.22120289
98STK110.21700343
99MAPK120.20589608
100PRKD10.18901164

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.80002425
2Leishmaniasis_Homo sapiens_hsa051403.15960369
3Allograft rejection_Homo sapiens_hsa053303.06200835
4Graft-versus-host disease_Homo sapiens_hsa053322.92758110
5Autoimmune thyroid disease_Homo sapiens_hsa053202.86702506
6B cell receptor signaling pathway_Homo sapiens_hsa046622.70294403
7Staphylococcus aureus infection_Homo sapiens_hsa051502.40704319
8Osteoclast differentiation_Homo sapiens_hsa043802.39017078
9Type I diabetes mellitus_Homo sapiens_hsa049402.25122326
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.21681399
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20028957
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12297887
13Tuberculosis_Homo sapiens_hsa051522.10309671
14Viral myocarditis_Homo sapiens_hsa054162.07795712
15Antigen processing and presentation_Homo sapiens_hsa046122.05641581
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05534658
17Asthma_Homo sapiens_hsa053101.94416797
18Measles_Homo sapiens_hsa051621.86395736
19Influenza A_Homo sapiens_hsa051641.77906578
20Hematopoietic cell lineage_Homo sapiens_hsa046401.75285644
21Herpes simplex infection_Homo sapiens_hsa051681.70722481
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69037816
23Acute myeloid leukemia_Homo sapiens_hsa052211.67987473
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60721163
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49828030
26Toxoplasmosis_Homo sapiens_hsa051451.49477795
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.48253342
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43805382
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42049973
30Chemokine signaling pathway_Homo sapiens_hsa040621.41628996
31Phagosome_Homo sapiens_hsa041451.32841148
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26990842
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.24438884
34T cell receptor signaling pathway_Homo sapiens_hsa046601.21284470
35Hepatitis C_Homo sapiens_hsa051601.19667821
36Platelet activation_Homo sapiens_hsa046111.19072971
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18452150
38Non-small cell lung cancer_Homo sapiens_hsa052231.15022711
39Shigellosis_Homo sapiens_hsa051311.12716988
40Legionellosis_Homo sapiens_hsa051341.09947351
41Epstein-Barr virus infection_Homo sapiens_hsa051691.06897081
42Malaria_Homo sapiens_hsa051441.06324591
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05849700
44Hepatitis B_Homo sapiens_hsa051611.04103964
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01173171
46Apoptosis_Homo sapiens_hsa042100.97836825
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.94930881
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92717900
49African trypanosomiasis_Homo sapiens_hsa051430.92223811
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92218634
51Rheumatoid arthritis_Homo sapiens_hsa053230.91991886
52Systemic lupus erythematosus_Homo sapiens_hsa053220.91601302
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88271520
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88085151
55Pancreatic cancer_Homo sapiens_hsa052120.81551666
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.78036315
57Endocytosis_Homo sapiens_hsa041440.77574278
58TNF signaling pathway_Homo sapiens_hsa046680.77047528
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75064865
60Chronic myeloid leukemia_Homo sapiens_hsa052200.74182843
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71273326
62Regulation of autophagy_Homo sapiens_hsa041400.70504964
63Viral carcinogenesis_Homo sapiens_hsa052030.65436504
64VEGF signaling pathway_Homo sapiens_hsa043700.64676527
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63672575
66HTLV-I infection_Homo sapiens_hsa051660.62372154
67Salmonella infection_Homo sapiens_hsa051320.57107894
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.54474435
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54361922
70Base excision repair_Homo sapiens_hsa034100.54111860
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53613619
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.53314781
73Dorso-ventral axis formation_Homo sapiens_hsa043200.51879079
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.49751505
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47994410
76mTOR signaling pathway_Homo sapiens_hsa041500.47386509
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46186472
78Pertussis_Homo sapiens_hsa051330.44993864
79Other glycan degradation_Homo sapiens_hsa005110.44240211
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43302755
81Olfactory transduction_Homo sapiens_hsa047400.42201772
82MAPK signaling pathway_Homo sapiens_hsa040100.40441793
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.40325013
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.40207171
85Prolactin signaling pathway_Homo sapiens_hsa049170.38967524
86ErbB signaling pathway_Homo sapiens_hsa040120.37559281
87Endometrial cancer_Homo sapiens_hsa052130.37143995
88GnRH signaling pathway_Homo sapiens_hsa049120.36949386
89Inositol phosphate metabolism_Homo sapiens_hsa005620.33608244
90Renal cell carcinoma_Homo sapiens_hsa052110.33220593
91Choline metabolism in cancer_Homo sapiens_hsa052310.33173423
92Alcoholism_Homo sapiens_hsa050340.33129682
93Lysosome_Homo sapiens_hsa041420.30334829
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28731099
95HIF-1 signaling pathway_Homo sapiens_hsa040660.27499594
96Glioma_Homo sapiens_hsa052140.25689565
97Rap1 signaling pathway_Homo sapiens_hsa040150.24679369
98Notch signaling pathway_Homo sapiens_hsa043300.22934098
99Colorectal cancer_Homo sapiens_hsa052100.22726259
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20950124

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