

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.28922810 |
| 2 | leukotriene biosynthetic process (GO:0019370) | 5.96979979 |
| 3 | behavioral response to nicotine (GO:0035095) | 5.58421320 |
| 4 | growth hormone secretion (GO:0030252) | 5.30322035 |
| 5 | protein K11-linked deubiquitination (GO:0035871) | 5.23961321 |
| 6 | organelle membrane fusion (GO:0090174) | 5.23362623 |
| 7 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 5.19588848 |
| 8 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.12088596 |
| 9 | cysteine metabolic process (GO:0006534) | 5.08009908 |
| 10 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 5.05010929 |
| 11 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 4.87898990 |
| 12 | regulation of RIG-I signaling pathway (GO:0039535) | 4.70678370 |
| 13 | cytidine deamination (GO:0009972) | 4.67435815 |
| 14 | cytidine metabolic process (GO:0046087) | 4.67435815 |
| 15 | cytidine catabolic process (GO:0006216) | 4.67435815 |
| 16 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.54345959 |
| 17 | positive regulation of growth hormone secretion (GO:0060124) | 4.24386312 |
| 18 | sulfation (GO:0051923) | 4.12201916 |
| 19 | positive regulation of prostaglandin secretion (GO:0032308) | 4.11554046 |
| 20 | leukotriene metabolic process (GO:0006691) | 4.11446746 |
| 21 | mitochondrial calcium ion transport (GO:0006851) | 4.09644875 |
| 22 | protein polyglutamylation (GO:0018095) | 4.06997462 |
| 23 | transmission of nerve impulse (GO:0019226) | 4.02352926 |
| 24 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 3.98345706 |
| 25 | piRNA metabolic process (GO:0034587) | 3.96116865 |
| 26 | iron-sulfur cluster assembly (GO:0016226) | 3.81505344 |
| 27 | metallo-sulfur cluster assembly (GO:0031163) | 3.81505344 |
| 28 | neuronal action potential (GO:0019228) | 3.80371276 |
| 29 | NIK/NF-kappaB signaling (GO:0038061) | 3.75616096 |
| 30 | gamma-aminobutyric acid transport (GO:0015812) | 3.75223882 |
| 31 | negative regulation of mast cell activation (GO:0033004) | 3.70457862 |
| 32 | activated T cell proliferation (GO:0050798) | 3.68951972 |
| 33 | axoneme assembly (GO:0035082) | 3.67862695 |
| 34 | autophagic vacuole fusion (GO:0000046) | 3.62748015 |
| 35 | negative regulation of telomere maintenance (GO:0032205) | 3.54829537 |
| 36 | estrogen biosynthetic process (GO:0006703) | 3.53640461 |
| 37 | sulfate transmembrane transport (GO:1902358) | 3.50512606 |
| 38 | protein K48-linked deubiquitination (GO:0071108) | 3.45800386 |
| 39 | negative T cell selection (GO:0043383) | 3.43688412 |
| 40 | determination of adult lifespan (GO:0008340) | 3.41847290 |
| 41 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 3.37027143 |
| 42 | synaptic transmission, cholinergic (GO:0007271) | 3.33705819 |
| 43 | positive regulation of action potential (GO:0045760) | 3.33344891 |
| 44 | regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) | 3.31777169 |
| 45 | regulation of prostaglandin secretion (GO:0032306) | 3.30380235 |
| 46 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.29779731 |
| 47 | fatty acid derivative biosynthetic process (GO:1901570) | 3.27158304 |
| 48 | icosanoid biosynthetic process (GO:0046456) | 3.27158304 |
| 49 | glycerophospholipid catabolic process (GO:0046475) | 3.21639115 |
| 50 | retinal cone cell development (GO:0046549) | 3.21636981 |
| 51 | negative regulation of oxidoreductase activity (GO:0051354) | 3.20327656 |
| 52 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.15851456 |
| 53 | GDP-mannose metabolic process (GO:0019673) | 3.11851398 |
| 54 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.08789517 |
| 55 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.06682170 |
| 56 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.04832762 |
| 57 | positive thymic T cell selection (GO:0045059) | 3.02196695 |
| 58 | negative thymic T cell selection (GO:0045060) | 3.00500288 |
| 59 | adaptation of signaling pathway (GO:0023058) | 3.00146976 |
| 60 | unsaturated fatty acid biosynthetic process (GO:0006636) | 2.99050331 |
| 61 | regulation of action potential (GO:0098900) | 2.98889529 |
| 62 | DNA methylation involved in gamete generation (GO:0043046) | 2.96541977 |
| 63 | sulfate transport (GO:0008272) | 2.95960848 |
| 64 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.95261780 |
| 65 | killing of cells of other organism (GO:0031640) | 2.90806791 |
| 66 | disruption of cells of other organism (GO:0044364) | 2.90806791 |
| 67 | L-fucose metabolic process (GO:0042354) | 2.85052630 |
| 68 | L-fucose catabolic process (GO:0042355) | 2.85052630 |
| 69 | fucose catabolic process (GO:0019317) | 2.85052630 |
| 70 | negative regulation of monooxygenase activity (GO:0032769) | 2.83131178 |
| 71 | positive T cell selection (GO:0043368) | 2.82028594 |
| 72 | positive regulation of fatty acid transport (GO:2000193) | 2.80731380 |
| 73 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.79276484 |
| 74 | regulation of protein polyubiquitination (GO:1902914) | 2.78868162 |
| 75 | neuron fate determination (GO:0048664) | 2.78649577 |
| 76 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 2.76779384 |
| 77 | activation of adenylate cyclase activity (GO:0007190) | 2.75474439 |
| 78 | dosage compensation (GO:0007549) | 2.74391087 |
| 79 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.73879332 |
| 80 | glutathione metabolic process (GO:0006749) | 2.73313566 |
| 81 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.72475315 |
| 82 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.72475315 |
| 83 | NADH dehydrogenase complex assembly (GO:0010257) | 2.72475315 |
| 84 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.72118887 |
| 85 | response to UV-C (GO:0010225) | 2.71969264 |
| 86 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.70342811 |
| 87 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.70318359 |
| 88 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.69970670 |
| 89 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.69970670 |
| 90 | modulation by symbiont of host immune response (GO:0052553) | 2.69970670 |
| 91 | positive regulation by symbiont of host defense response (GO:0052509) | 2.69970670 |
| 92 | modulation by symbiont of host defense response (GO:0052031) | 2.69970670 |
| 93 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.69970670 |
| 94 | regulation of ruffle assembly (GO:1900027) | 2.66263479 |
| 95 | response to interferon-beta (GO:0035456) | 2.63858720 |
| 96 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 2.63060012 |
| 97 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 2.63060012 |
| 98 | natural killer cell differentiation (GO:0001779) | 2.62965455 |
| 99 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.62513389 |
| 100 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.62027811 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.57768574 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.13028484 |
| 3 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.57549755 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.43684837 |
| 5 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 3.19166379 |
| 6 | VDR_22108803_ChIP-Seq_LS180_Human | 3.07231411 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.76347233 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.64032562 |
| 9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.62106168 |
| 10 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.43497271 |
| 11 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.41812259 |
| 12 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.32085843 |
| 13 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.26289297 |
| 14 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.15147395 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.14259377 |
| 16 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.07698468 |
| 17 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.06143040 |
| 18 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.90097939 |
| 19 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.88448120 |
| 20 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.88160287 |
| 21 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.87867512 |
| 22 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.83398646 |
| 23 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.66983102 |
| 24 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.65880474 |
| 25 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.65400424 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.62570549 |
| 27 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.61865927 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.57418494 |
| 29 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.56881017 |
| 30 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.54192716 |
| 31 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.54060265 |
| 32 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.49253652 |
| 33 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49250255 |
| 34 | ERA_21632823_ChIP-Seq_H3396_Human | 1.42989569 |
| 35 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.37175583 |
| 36 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.35167260 |
| 37 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.29785343 |
| 38 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.28458246 |
| 39 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.27940027 |
| 40 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.23696418 |
| 41 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.22319291 |
| 42 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.21961170 |
| 43 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.21209360 |
| 44 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.19154867 |
| 45 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.17512706 |
| 46 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.16884533 |
| 47 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.15418492 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15099625 |
| 49 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.14536743 |
| 50 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.13038487 |
| 51 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.12961224 |
| 52 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.12675286 |
| 53 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.12675286 |
| 54 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.11762863 |
| 55 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.11728699 |
| 56 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.11646978 |
| 57 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.09886233 |
| 58 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.09660294 |
| 59 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.08556245 |
| 60 | MYB_26560356_Chip-Seq_TH2_Human | 1.07998401 |
| 61 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.07913860 |
| 62 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.05899386 |
| 63 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.05419774 |
| 64 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.05172825 |
| 65 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.05048884 |
| 66 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.04258227 |
| 67 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.03381869 |
| 68 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.02863288 |
| 69 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01867048 |
| 70 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.00931417 |
| 71 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.00805338 |
| 72 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99649519 |
| 73 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.98913385 |
| 74 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.98801998 |
| 75 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.97693533 |
| 76 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.97693533 |
| 77 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.97488366 |
| 78 | SOX3_22085726_ChIP-Seq_MUSCLE_Mouse | 0.97382381 |
| 79 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.97170169 |
| 80 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.96891270 |
| 81 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.96742915 |
| 82 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.96645348 |
| 83 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.96207917 |
| 84 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.96035811 |
| 85 | P300_27268052_Chip-Seq_Bcells_Human | 0.95980504 |
| 86 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.94716583 |
| 87 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.94469694 |
| 88 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.93736098 |
| 89 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.93708156 |
| 90 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.93305605 |
| 91 | GATA3_26560356_Chip-Seq_TH2_Human | 0.92689587 |
| 92 | EWS_26573619_Chip-Seq_HEK293_Human | 0.92475648 |
| 93 | UTX_26944678_Chip-Seq_JUKART_Human | 0.92439395 |
| 94 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.91820548 |
| 95 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.90749473 |
| 96 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.90702808 |
| 97 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.89343004 |
| 98 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.89076887 |
| 99 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.87427566 |
| 100 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.86489551 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003183_abnormal_peptide_metabolism | 4.32720840 |
| 2 | MP0002822_catalepsy | 3.56826067 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.22232424 |
| 4 | MP0005645_abnormal_hypothalamus_physiol | 3.09358449 |
| 5 | MP0005248_abnormal_Harderian_gland | 3.00839860 |
| 6 | MP0002736_abnormal_nociception_after | 2.94527722 |
| 7 | MP0002102_abnormal_ear_morphology | 2.58326080 |
| 8 | MP0006276_abnormal_autonomic_nervous | 2.52544743 |
| 9 | MP0002909_abnormal_adrenal_gland | 2.48291648 |
| 10 | MP0005671_abnormal_response_to | 2.33536382 |
| 11 | MP0005551_abnormal_eye_electrophysiolog | 2.15507527 |
| 12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.15329040 |
| 13 | MP0001873_stomach_inflammation | 2.12136105 |
| 14 | MP0000613_abnormal_salivary_gland | 2.01261202 |
| 15 | MP0001501_abnormal_sleep_pattern | 1.90735361 |
| 16 | MP0002254_reproductive_system_inflammat | 1.88959146 |
| 17 | MP0008995_early_reproductive_senescence | 1.88952754 |
| 18 | MP0001968_abnormal_touch/_nociception | 1.79395380 |
| 19 | MP0005310_abnormal_salivary_gland | 1.73159564 |
| 20 | MP0001529_abnormal_vocalization | 1.71598515 |
| 21 | MP0005647_abnormal_sex_gland | 1.64473583 |
| 22 | MP0009333_abnormal_splenocyte_physiolog | 1.63938477 |
| 23 | MP0002733_abnormal_thermal_nociception | 1.57372880 |
| 24 | MP0003195_calcinosis | 1.52622954 |
| 25 | MP0010030_abnormal_orbit_morphology | 1.52348045 |
| 26 | MP0003787_abnormal_imprinting | 1.51371495 |
| 27 | MP0009764_decreased_sensitivity_to | 1.50515816 |
| 28 | MP0008961_abnormal_basal_metabolism | 1.49599162 |
| 29 | MP0001800_abnormal_humoral_immune | 1.49277152 |
| 30 | MP0008872_abnormal_physiological_respon | 1.41545546 |
| 31 | MP0005646_abnormal_pituitary_gland | 1.41392024 |
| 32 | MP0002735_abnormal_chemical_nociception | 1.40508754 |
| 33 | MP0001485_abnormal_pinna_reflex | 1.39644125 |
| 34 | MP0009785_altered_susceptibility_to | 1.39268974 |
| 35 | MP0004742_abnormal_vestibular_system | 1.38839049 |
| 36 | MP0003724_increased_susceptibility_to | 1.35880335 |
| 37 | MP0005000_abnormal_immune_tolerance | 1.34397470 |
| 38 | MP0002277_abnormal_respiratory_mucosa | 1.34335321 |
| 39 | MP0006082_CNS_inflammation | 1.32943464 |
| 40 | MP0003436_decreased_susceptibility_to | 1.31665405 |
| 41 | MP0002723_abnormal_immune_serum | 1.29481872 |
| 42 | MP0001970_abnormal_pain_threshold | 1.21095890 |
| 43 | MP0005025_abnormal_response_to | 1.20769798 |
| 44 | MP0002138_abnormal_hepatobiliary_system | 1.19907056 |
| 45 | MP0006292_abnormal_olfactory_placode | 1.19841452 |
| 46 | MP0009745_abnormal_behavioral_response | 1.19282271 |
| 47 | MP0002420_abnormal_adaptive_immunity | 1.19177329 |
| 48 | MP0000685_abnormal_immune_system | 1.18745855 |
| 49 | MP0001819_abnormal_immune_cell | 1.16653130 |
| 50 | MP0005266_abnormal_metabolism | 1.13685299 |
| 51 | MP0008874_decreased_physiological_sensi | 1.13544189 |
| 52 | MP0003122_maternal_imprinting | 1.13110779 |
| 53 | MP0002452_abnormal_antigen_presenting | 1.11946137 |
| 54 | MP0001881_abnormal_mammary_gland | 1.09224993 |
| 55 | MP0002419_abnormal_innate_immunity | 1.07315338 |
| 56 | MP0001919_abnormal_reproductive_system | 1.06878607 |
| 57 | MP0001905_abnormal_dopamine_level | 1.06096482 |
| 58 | MP0002163_abnormal_gland_morphology | 1.05598486 |
| 59 | MP0000631_abnormal_neuroendocrine_gland | 1.05097505 |
| 60 | MP0004043_abnormal_pH_regulation | 1.04605516 |
| 61 | MP0000026_abnormal_inner_ear | 1.04357579 |
| 62 | MP0002405_respiratory_system_inflammati | 1.03199091 |
| 63 | MP0002064_seizures | 1.01943157 |
| 64 | MP0001984_abnormal_olfaction | 1.00541565 |
| 65 | MP0003936_abnormal_reproductive_system | 0.98734887 |
| 66 | MP0009046_muscle_twitch | 0.98087385 |
| 67 | MP0002229_neurodegeneration | 0.97757535 |
| 68 | MP0001663_abnormal_digestive_system | 0.95370571 |
| 69 | MP0005387_immune_system_phenotype | 0.94496566 |
| 70 | MP0001790_abnormal_immune_system | 0.94496566 |
| 71 | MP0005174_abnormal_tail_pigmentation | 0.94337961 |
| 72 | MP0000716_abnormal_immune_system | 0.92936185 |
| 73 | MP0008789_abnormal_olfactory_epithelium | 0.92720738 |
| 74 | MP0003763_abnormal_thymus_physiology | 0.92690938 |
| 75 | MP0008260_abnormal_autophagy | 0.91498842 |
| 76 | MP0003011_delayed_dark_adaptation | 0.91479979 |
| 77 | MP0003959_abnormal_lean_body | 0.90595395 |
| 78 | MP0002272_abnormal_nervous_system | 0.89935355 |
| 79 | MP0002006_tumorigenesis | 0.88942426 |
| 80 | MP0000372_irregular_coat_pigmentation | 0.88911197 |
| 81 | MP0002876_abnormal_thyroid_physiology | 0.88424033 |
| 82 | MP0001346_abnormal_lacrimal_gland | 0.87296075 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.85794323 |
| 84 | MP0003698_abnormal_male_reproductive | 0.85549269 |
| 85 | MP0002067_abnormal_sensory_capabilities | 0.84895787 |
| 86 | MP0001963_abnormal_hearing_physiology | 0.83664884 |
| 87 | MP0001835_abnormal_antigen_presentation | 0.83224854 |
| 88 | MP0002210_abnormal_sex_determination | 0.80740318 |
| 89 | MP0003635_abnormal_synaptic_transmissio | 0.80180838 |
| 90 | MP0005389_reproductive_system_phenotype | 0.78785336 |
| 91 | MP0000015_abnormal_ear_pigmentation | 0.76924243 |
| 92 | MP0001929_abnormal_gametogenesis | 0.75432544 |
| 93 | MP0002282_abnormal_trachea_morphology | 0.74866140 |
| 94 | MP0004924_abnormal_behavior | 0.73884927 |
| 95 | MP0005386_behavior/neurological_phenoty | 0.73884927 |
| 96 | MP0008873_increased_physiological_sensi | 0.73637688 |
| 97 | MP0005499_abnormal_olfactory_system | 0.72948824 |
| 98 | MP0005394_taste/olfaction_phenotype | 0.72948824 |
| 99 | MP0001486_abnormal_startle_reflex | 0.72339096 |
| 100 | MP0003283_abnormal_digestive_organ | 0.72191357 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Palpebral edema (HP:0100540) | 3.64187758 |
| 2 | Keratoconjunctivitis (HP:0001096) | 3.39911669 |
| 3 | Congenital sensorineural hearing impairment (HP:0008527) | 3.38471736 |
| 4 | Spastic paraparesis (HP:0002313) | 3.33377662 |
| 5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.32883749 |
| 6 | Amyotrophic lateral sclerosis (HP:0007354) | 3.21400217 |
| 7 | Tubular atrophy (HP:0000092) | 3.15584163 |
| 8 | Congenital stationary night blindness (HP:0007642) | 3.15475362 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.13243212 |
| 10 | Mitochondrial inheritance (HP:0001427) | 3.10247010 |
| 11 | Severe visual impairment (HP:0001141) | 3.06262975 |
| 12 | Pancreatic cysts (HP:0001737) | 3.02003520 |
| 13 | Attenuation of retinal blood vessels (HP:0007843) | 3.00975482 |
| 14 | Acute encephalopathy (HP:0006846) | 2.92435286 |
| 15 | True hermaphroditism (HP:0010459) | 2.89203219 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 2.86130268 |
| 17 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.85917204 |
| 18 | Abnormality of alanine metabolism (HP:0010916) | 2.85917204 |
| 19 | Hyperalaninemia (HP:0003348) | 2.85917204 |
| 20 | Abnormal drinking behavior (HP:0030082) | 2.81567878 |
| 21 | Polydipsia (HP:0001959) | 2.81567878 |
| 22 | Hypoalbuminemia (HP:0003073) | 2.78325662 |
| 23 | Abnormal albumin level (HP:0012116) | 2.78325662 |
| 24 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.78158715 |
| 25 | Increased CSF lactate (HP:0002490) | 2.74308225 |
| 26 | Retinal atrophy (HP:0001105) | 2.69158558 |
| 27 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.64484575 |
| 28 | Keratoconjunctivitis sicca (HP:0001097) | 2.63755479 |
| 29 | Aplastic anemia (HP:0001915) | 2.55016735 |
| 30 | Agammaglobulinemia (HP:0004432) | 2.54461488 |
| 31 | Pigmentary retinal degeneration (HP:0001146) | 2.53802160 |
| 32 | Abolished electroretinogram (ERG) (HP:0000550) | 2.52953484 |
| 33 | Abnormality of B cell number (HP:0010975) | 2.51811840 |
| 34 | Sensory axonal neuropathy (HP:0003390) | 2.50096724 |
| 35 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.49020829 |
| 36 | Retinal dysplasia (HP:0007973) | 2.46556963 |
| 37 | Tubulointerstitial fibrosis (HP:0005576) | 2.45880004 |
| 38 | Pancreatic fibrosis (HP:0100732) | 2.41581218 |
| 39 | Nephronophthisis (HP:0000090) | 2.38653803 |
| 40 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.36763256 |
| 41 | Retrobulbar optic neuritis (HP:0100654) | 2.36210901 |
| 42 | Optic neuritis (HP:0100653) | 2.36210901 |
| 43 | Orchitis (HP:0100796) | 2.33919220 |
| 44 | Abnormality of midbrain morphology (HP:0002418) | 2.33013754 |
| 45 | Molar tooth sign on MRI (HP:0002419) | 2.33013754 |
| 46 | B lymphocytopenia (HP:0010976) | 2.31083783 |
| 47 | Cerebral edema (HP:0002181) | 2.30247598 |
| 48 | Abnormal pancreas size (HP:0012094) | 2.30244684 |
| 49 | Hyperglycinemia (HP:0002154) | 2.29476218 |
| 50 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.28599506 |
| 51 | Increased hepatocellular lipid droplets (HP:0006565) | 2.27655117 |
| 52 | Polyuria (HP:0000103) | 2.27629151 |
| 53 | Hepatic necrosis (HP:0002605) | 2.27355376 |
| 54 | Abnormality of glycine metabolism (HP:0010895) | 2.23534556 |
| 55 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.23534556 |
| 56 | Emotional lability (HP:0000712) | 2.18231240 |
| 57 | Myositis (HP:0100614) | 2.17265445 |
| 58 | Lipid accumulation in hepatocytes (HP:0006561) | 2.16247526 |
| 59 | Keratitis (HP:0000491) | 2.15624222 |
| 60 | Exertional dyspnea (HP:0002875) | 2.15480548 |
| 61 | Tinnitus (HP:0000360) | 2.15141160 |
| 62 | Progressive macrocephaly (HP:0004481) | 2.13970227 |
| 63 | Recurrent cutaneous fungal infections (HP:0011370) | 2.12840380 |
| 64 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.12840380 |
| 65 | Abnormality of the renal medulla (HP:0100957) | 2.10802147 |
| 66 | Renal Fanconi syndrome (HP:0001994) | 2.10708069 |
| 67 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.10597442 |
| 68 | Progressive microcephaly (HP:0000253) | 2.09311209 |
| 69 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.08447987 |
| 70 | Recurrent corneal erosions (HP:0000495) | 2.05601778 |
| 71 | Short tibia (HP:0005736) | 2.03637850 |
| 72 | Opisthotonus (HP:0002179) | 2.02741841 |
| 73 | Slow saccadic eye movements (HP:0000514) | 2.02383199 |
| 74 | Stage 5 chronic kidney disease (HP:0003774) | 2.02259368 |
| 75 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.01684244 |
| 76 | Periorbital edema (HP:0100539) | 2.00994131 |
| 77 | 3-Methylglutaconic aciduria (HP:0003535) | 1.99680852 |
| 78 | Facial edema (HP:0000282) | 1.96606686 |
| 79 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.95150104 |
| 80 | Hyperglycinuria (HP:0003108) | 1.93356641 |
| 81 | Postaxial foot polydactyly (HP:0001830) | 1.92832206 |
| 82 | Gastrointestinal infarctions (HP:0005244) | 1.91669848 |
| 83 | Occipital encephalocele (HP:0002085) | 1.91021185 |
| 84 | Male pseudohermaphroditism (HP:0000037) | 1.90960424 |
| 85 | Inability to walk (HP:0002540) | 1.90194358 |
| 86 | Thrombocytosis (HP:0001894) | 1.90080977 |
| 87 | Cerebral hypomyelination (HP:0006808) | 1.89052639 |
| 88 | Recurrent pneumonia (HP:0006532) | 1.87633290 |
| 89 | Carpal bone hypoplasia (HP:0001498) | 1.86648888 |
| 90 | Abnormality of the renal cortex (HP:0011035) | 1.86482702 |
| 91 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.86440821 |
| 92 | Abnormal gallbladder physiology (HP:0012438) | 1.85913424 |
| 93 | Cholecystitis (HP:0001082) | 1.85913424 |
| 94 | Cystic liver disease (HP:0006706) | 1.84894938 |
| 95 | Abnormal urine output (HP:0012590) | 1.83714683 |
| 96 | Lissencephaly (HP:0001339) | 1.83469894 |
| 97 | Decreased central vision (HP:0007663) | 1.80223695 |
| 98 | Absent/shortened dynein arms (HP:0200106) | 1.78648864 |
| 99 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.78648864 |
| 100 | Cerebellar dysplasia (HP:0007033) | 1.77896143 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 6.35930882 |
| 2 | KDR | 4.74508278 |
| 3 | TESK2 | 4.69718290 |
| 4 | PIM2 | 3.81964893 |
| 5 | MAP4K2 | 2.64470950 |
| 6 | GRK6 | 2.63057416 |
| 7 | SIK2 | 2.61264167 |
| 8 | LIMK1 | 2.30088314 |
| 9 | TAOK3 | 2.29226464 |
| 10 | TESK1 | 2.25918198 |
| 11 | ARAF | 2.22113197 |
| 12 | MAP4K1 | 2.02104087 |
| 13 | NUAK1 | 1.90369859 |
| 14 | GRK1 | 1.82750068 |
| 15 | TXK | 1.72248670 |
| 16 | MAP3K11 | 1.67615849 |
| 17 | IRAK4 | 1.67482182 |
| 18 | MAP3K4 | 1.46622888 |
| 19 | FRK | 1.46128685 |
| 20 | MAP3K12 | 1.40061420 |
| 21 | INSRR | 1.36722758 |
| 22 | KIT | 1.36637690 |
| 23 | MAP3K9 | 1.36208183 |
| 24 | MAPKAPK3 | 1.33709520 |
| 25 | ADRBK2 | 1.31608821 |
| 26 | WNK3 | 1.30546838 |
| 27 | BLK | 1.29431578 |
| 28 | CAMKK2 | 1.22226494 |
| 29 | NME1 | 1.20377248 |
| 30 | ZAK | 1.20326264 |
| 31 | DAPK1 | 1.20019018 |
| 32 | EIF2AK3 | 1.11943042 |
| 33 | PINK1 | 1.10808989 |
| 34 | BMX | 1.04869736 |
| 35 | PRKD3 | 1.03025248 |
| 36 | MAP3K6 | 1.01142618 |
| 37 | VRK2 | 0.98925771 |
| 38 | RAF1 | 0.97348194 |
| 39 | SIK3 | 0.95986055 |
| 40 | SYK | 0.95945850 |
| 41 | TAOK1 | 0.93803449 |
| 42 | BRSK2 | 0.92900099 |
| 43 | GRK5 | 0.90164031 |
| 44 | MATK | 0.89707220 |
| 45 | IKBKE | 0.89207710 |
| 46 | DYRK1B | 0.85039927 |
| 47 | CDK19 | 0.80969642 |
| 48 | LYN | 0.77024717 |
| 49 | MAP3K5 | 0.76559402 |
| 50 | MAPKAPK5 | 0.75874157 |
| 51 | MAPK13 | 0.69739389 |
| 52 | PRKCQ | 0.68578326 |
| 53 | PIM1 | 0.67296834 |
| 54 | ADRBK1 | 0.66717342 |
| 55 | KSR1 | 0.66274714 |
| 56 | RPS6KA5 | 0.64038729 |
| 57 | MAP3K1 | 0.61885253 |
| 58 | DYRK2 | 0.61176955 |
| 59 | MAP3K2 | 0.60955727 |
| 60 | ABL2 | 0.60614395 |
| 61 | CCNB1 | 0.60014753 |
| 62 | PTK2B | 0.53022814 |
| 63 | NTRK3 | 0.52893841 |
| 64 | LMTK2 | 0.51435474 |
| 65 | PRKCH | 0.50820978 |
| 66 | BMPR1B | 0.49253665 |
| 67 | TAOK2 | 0.49021972 |
| 68 | CSNK1G3 | 0.47737917 |
| 69 | LCK | 0.46131801 |
| 70 | MAPKAPK2 | 0.45404476 |
| 71 | ITK | 0.45312225 |
| 72 | TYRO3 | 0.45198523 |
| 73 | CSF1R | 0.44734877 |
| 74 | CSNK1G2 | 0.43969893 |
| 75 | TEC | 0.43783306 |
| 76 | MARK3 | 0.41003260 |
| 77 | PASK | 0.40676634 |
| 78 | IRAK1 | 0.37206482 |
| 79 | IKBKB | 0.36017186 |
| 80 | TIE1 | 0.35876606 |
| 81 | CSNK1A1L | 0.34438608 |
| 82 | PRKD2 | 0.33547218 |
| 83 | CAMKK1 | 0.32498826 |
| 84 | PRKCI | 0.32055490 |
| 85 | LATS1 | 0.31562581 |
| 86 | BTK | 0.31412824 |
| 87 | CHEK2 | 0.30666774 |
| 88 | KSR2 | 0.30045631 |
| 89 | DAPK3 | 0.28412976 |
| 90 | INSR | 0.28113283 |
| 91 | TRIM28 | 0.27380971 |
| 92 | CAMK2B | 0.26540388 |
| 93 | IRAK3 | 0.26518059 |
| 94 | TGFBR1 | 0.25882445 |
| 95 | MAP2K7 | 0.25034421 |
| 96 | ATR | 0.24846635 |
| 97 | MAP3K3 | 0.24518414 |
| 98 | DDR2 | 0.23763270 |
| 99 | SCYL2 | 0.22402425 |
| 100 | PLK4 | 0.22350430 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.46446908 |
| 2 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.71959387 |
| 3 | Sulfur relay system_Homo sapiens_hsa04122 | 2.86188014 |
| 4 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.54585217 |
| 5 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.47018240 |
| 6 | Nicotine addiction_Homo sapiens_hsa05033 | 2.45326798 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.42058362 |
| 8 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 2.20009968 |
| 9 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.04369148 |
| 10 | Phototransduction_Homo sapiens_hsa04744 | 2.02719083 |
| 11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.02020319 |
| 12 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.97819760 |
| 13 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.95848405 |
| 14 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.90916922 |
| 15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.85841648 |
| 16 | Allograft rejection_Homo sapiens_hsa05330 | 1.73673104 |
| 17 | Parkinsons disease_Homo sapiens_hsa05012 | 1.68776198 |
| 18 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.60367633 |
| 19 | Base excision repair_Homo sapiens_hsa03410 | 1.47963640 |
| 20 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.46340260 |
| 21 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.46206475 |
| 22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.44215362 |
| 23 | RNA polymerase_Homo sapiens_hsa03020 | 1.44065256 |
| 24 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.42204599 |
| 25 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.42176574 |
| 26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.38984990 |
| 27 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.35541935 |
| 28 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.34832883 |
| 29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.33317015 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.26844516 |
| 31 | Taste transduction_Homo sapiens_hsa04742 | 1.20881225 |
| 32 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.20217808 |
| 33 | Histidine metabolism_Homo sapiens_hsa00340 | 1.19177676 |
| 34 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.19069853 |
| 35 | Olfactory transduction_Homo sapiens_hsa04740 | 1.18829484 |
| 36 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.17896906 |
| 37 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.17224618 |
| 38 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.16985608 |
| 39 | Huntingtons disease_Homo sapiens_hsa05016 | 1.14847777 |
| 40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.12248059 |
| 41 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.10915297 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.10897631 |
| 43 | Morphine addiction_Homo sapiens_hsa05032 | 1.09684153 |
| 44 | Alzheimers disease_Homo sapiens_hsa05010 | 1.05346213 |
| 45 | Ribosome_Homo sapiens_hsa03010 | 1.03994105 |
| 46 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.03864078 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.01019958 |
| 48 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.98218192 |
| 49 | Purine metabolism_Homo sapiens_hsa00230 | 0.97969256 |
| 50 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.91453882 |
| 51 | Proteasome_Homo sapiens_hsa03050 | 0.88114538 |
| 52 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.84693554 |
| 53 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.84443079 |
| 54 | Measles_Homo sapiens_hsa05162 | 0.79773605 |
| 55 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.78518548 |
| 56 | Salivary secretion_Homo sapiens_hsa04970 | 0.74714742 |
| 57 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.73346752 |
| 58 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.73316633 |
| 59 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.72518976 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.72283816 |
| 61 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.72021857 |
| 62 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71324190 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.68435485 |
| 64 | Asthma_Homo sapiens_hsa05310 | 0.68285549 |
| 65 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.65905455 |
| 66 | ABC transporters_Homo sapiens_hsa02010 | 0.65886867 |
| 67 | Cocaine addiction_Homo sapiens_hsa05030 | 0.63853172 |
| 68 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.62890749 |
| 69 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.60374439 |
| 70 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.60356117 |
| 71 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.59558506 |
| 72 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.59333925 |
| 73 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.58120461 |
| 74 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.58036664 |
| 75 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.56731889 |
| 76 | GABAergic synapse_Homo sapiens_hsa04727 | 0.56220660 |
| 77 | Homologous recombination_Homo sapiens_hsa03440 | 0.55939094 |
| 78 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.55253241 |
| 79 | Basal transcription factors_Homo sapiens_hsa03022 | 0.55181334 |
| 80 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.54922869 |
| 81 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.52153266 |
| 82 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.51252402 |
| 83 | Viral myocarditis_Homo sapiens_hsa05416 | 0.51158625 |
| 84 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.45943896 |
| 85 | Metabolic pathways_Homo sapiens_hsa01100 | 0.44765328 |
| 86 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.42828537 |
| 87 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39539464 |
| 88 | Malaria_Homo sapiens_hsa05144 | 0.39050318 |
| 89 | Phagosome_Homo sapiens_hsa04145 | 0.38325093 |
| 90 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.37854173 |
| 91 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.37017378 |
| 92 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.36400914 |
| 93 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.35936465 |
| 94 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.34255475 |
| 95 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.32895659 |
| 96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.32738219 |
| 97 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.30701688 |
| 98 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.28050445 |
| 99 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.27427310 |
| 100 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.27159910 |

