DUX4L9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.28922810
2leukotriene biosynthetic process (GO:0019370)5.96979979
3behavioral response to nicotine (GO:0035095)5.58421320
4growth hormone secretion (GO:0030252)5.30322035
5protein K11-linked deubiquitination (GO:0035871)5.23961321
6organelle membrane fusion (GO:0090174)5.23362623
7positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.19588848
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.12088596
9cysteine metabolic process (GO:0006534)5.08009908
10chaperone mediated protein folding requiring cofactor (GO:0051085)5.05010929
11positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.87898990
12regulation of RIG-I signaling pathway (GO:0039535)4.70678370
13cytidine deamination (GO:0009972)4.67435815
14cytidine metabolic process (GO:0046087)4.67435815
15cytidine catabolic process (GO:0006216)4.67435815
16pyrimidine ribonucleoside catabolic process (GO:0046133)4.54345959
17positive regulation of growth hormone secretion (GO:0060124)4.24386312
18sulfation (GO:0051923)4.12201916
19positive regulation of prostaglandin secretion (GO:0032308)4.11554046
20leukotriene metabolic process (GO:0006691)4.11446746
21mitochondrial calcium ion transport (GO:0006851)4.09644875
22protein polyglutamylation (GO:0018095)4.06997462
23transmission of nerve impulse (GO:0019226)4.02352926
24regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.98345706
25piRNA metabolic process (GO:0034587)3.96116865
26iron-sulfur cluster assembly (GO:0016226)3.81505344
27metallo-sulfur cluster assembly (GO:0031163)3.81505344
28neuronal action potential (GO:0019228)3.80371276
29NIK/NF-kappaB signaling (GO:0038061)3.75616096
30gamma-aminobutyric acid transport (GO:0015812)3.75223882
31negative regulation of mast cell activation (GO:0033004)3.70457862
32activated T cell proliferation (GO:0050798)3.68951972
33axoneme assembly (GO:0035082)3.67862695
34autophagic vacuole fusion (GO:0000046)3.62748015
35negative regulation of telomere maintenance (GO:0032205)3.54829537
36estrogen biosynthetic process (GO:0006703)3.53640461
37sulfate transmembrane transport (GO:1902358)3.50512606
38protein K48-linked deubiquitination (GO:0071108)3.45800386
39negative T cell selection (GO:0043383)3.43688412
40determination of adult lifespan (GO:0008340)3.41847290
41negative regulation of calcium ion transport into cytosol (GO:0010523)3.37027143
42synaptic transmission, cholinergic (GO:0007271)3.33705819
43positive regulation of action potential (GO:0045760)3.33344891
44regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.31777169
45regulation of prostaglandin secretion (GO:0032306)3.30380235
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29779731
47fatty acid derivative biosynthetic process (GO:1901570)3.27158304
48icosanoid biosynthetic process (GO:0046456)3.27158304
49glycerophospholipid catabolic process (GO:0046475)3.21639115
50retinal cone cell development (GO:0046549)3.21636981
51negative regulation of oxidoreductase activity (GO:0051354)3.20327656
52regulation of T cell mediated cytotoxicity (GO:0001914)3.15851456
53GDP-mannose metabolic process (GO:0019673)3.11851398
54pyrimidine nucleoside catabolic process (GO:0046135)3.08789517
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06682170
56preassembly of GPI anchor in ER membrane (GO:0016254)3.04832762
57positive thymic T cell selection (GO:0045059)3.02196695
58negative thymic T cell selection (GO:0045060)3.00500288
59adaptation of signaling pathway (GO:0023058)3.00146976
60unsaturated fatty acid biosynthetic process (GO:0006636)2.99050331
61regulation of action potential (GO:0098900)2.98889529
62DNA methylation involved in gamete generation (GO:0043046)2.96541977
63sulfate transport (GO:0008272)2.95960848
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95261780
65killing of cells of other organism (GO:0031640)2.90806791
66disruption of cells of other organism (GO:0044364)2.90806791
67L-fucose metabolic process (GO:0042354)2.85052630
68L-fucose catabolic process (GO:0042355)2.85052630
69fucose catabolic process (GO:0019317)2.85052630
70negative regulation of monooxygenase activity (GO:0032769)2.83131178
71positive T cell selection (GO:0043368)2.82028594
72positive regulation of fatty acid transport (GO:2000193)2.80731380
73pyrimidine nucleotide catabolic process (GO:0006244)2.79276484
74regulation of protein polyubiquitination (GO:1902914)2.78868162
75neuron fate determination (GO:0048664)2.78649577
76phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76779384
77activation of adenylate cyclase activity (GO:0007190)2.75474439
78dosage compensation (GO:0007549)2.74391087
79cilium or flagellum-dependent cell motility (GO:0001539)2.73879332
80glutathione metabolic process (GO:0006749)2.73313566
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72475315
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.72475315
83NADH dehydrogenase complex assembly (GO:0010257)2.72475315
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72118887
85response to UV-C (GO:0010225)2.71969264
86positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.70342811
87regulation of B cell receptor signaling pathway (GO:0050855)2.70318359
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69970670
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.69970670
90modulation by symbiont of host immune response (GO:0052553)2.69970670
91positive regulation by symbiont of host defense response (GO:0052509)2.69970670
92modulation by symbiont of host defense response (GO:0052031)2.69970670
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69970670
94regulation of ruffle assembly (GO:1900027)2.66263479
95response to interferon-beta (GO:0035456)2.63858720
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.63060012
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.63060012
98natural killer cell differentiation (GO:0001779)2.62965455
99water-soluble vitamin biosynthetic process (GO:0042364)2.62513389
100regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62027811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57768574
2GBX2_23144817_ChIP-Seq_PC3_Human4.13028484
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.57549755
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.43684837
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.19166379
6VDR_22108803_ChIP-Seq_LS180_Human3.07231411
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.76347233
8ZNF274_21170338_ChIP-Seq_K562_Hela2.64032562
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62106168
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43497271
11DROSHA_22980978_ChIP-Seq_HELA_Human2.41812259
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32085843
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26289297
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.15147395
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14259377
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07698468
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06143040
18TAF15_26573619_Chip-Seq_HEK293_Human1.90097939
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.88448120
20TP53_22573176_ChIP-Seq_HFKS_Human1.88160287
21IGF1R_20145208_ChIP-Seq_DFB_Human1.87867512
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.83398646
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66983102
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.65880474
25IRF1_19129219_ChIP-ChIP_H3396_Human1.65400424
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62570549
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61865927
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57418494
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56881017
30ER_23166858_ChIP-Seq_MCF-7_Human1.54192716
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54060265
32REST_21632747_ChIP-Seq_MESCs_Mouse1.49253652
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49250255
34ERA_21632823_ChIP-Seq_H3396_Human1.42989569
35BCL6_27268052_Chip-Seq_Bcells_Human1.37175583
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35167260
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29785343
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.28458246
39EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.27940027
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23696418
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.22319291
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21961170
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.21209360
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19154867
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17512706
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16884533
47OCT4_20526341_ChIP-Seq_ESCs_Human1.15418492
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15099625
49HOXB7_26014856_ChIP-Seq_BT474_Human1.14536743
50RUNX_20019798_ChIP-Seq_JUKART_Human1.13038487
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12961224
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12675286
53CBP_20019798_ChIP-Seq_JUKART_Human1.12675286
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11762863
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11728699
56BCAT_22108803_ChIP-Seq_LS180_Human1.11646978
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09886233
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09660294
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08556245
60MYB_26560356_Chip-Seq_TH2_Human1.07998401
61RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07913860
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05899386
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.05419774
64NANOG_20526341_ChIP-Seq_ESCs_Human1.05172825
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05048884
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.04258227
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03381869
68CTCF_20526341_ChIP-Seq_ESCs_Human1.02863288
69NCOR_22424771_ChIP-Seq_293T_Human1.01867048
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00931417
71STAT1_17558387_ChIP-Seq_HELA_Human1.00805338
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99649519
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98913385
74RAC3_21632823_ChIP-Seq_H3396_Human0.98801998
75FOXA1_25329375_ChIP-Seq_VCAP_Human0.97693533
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97693533
77MYC_19829295_ChIP-Seq_ESCs_Human0.97488366
78SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.97382381
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97170169
80FOXH1_21741376_ChIP-Seq_EPCs_Human0.96891270
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96742915
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96645348
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96207917
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96035811
85P300_27268052_Chip-Seq_Bcells_Human0.95980504
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94716583
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94469694
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93736098
89ERG_20517297_ChIP-Seq_VCAP_Human0.93708156
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93305605
91GATA3_26560356_Chip-Seq_TH2_Human0.92689587
92EWS_26573619_Chip-Seq_HEK293_Human0.92475648
93UTX_26944678_Chip-Seq_JUKART_Human0.92439395
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.91820548
95MYC_18940864_ChIP-ChIP_HL60_Human0.90749473
96EZH2_27304074_Chip-Seq_ESCs_Mouse0.90702808
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.89343004
98E2F1_20622854_ChIP-Seq_HELA_Human0.89076887
99RUNX2_22187159_ChIP-Seq_PCA_Human0.87427566
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86489551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.32720840
2MP0002822_catalepsy3.56826067
3MP0008877_abnormal_DNA_methylation3.22232424
4MP0005645_abnormal_hypothalamus_physiol3.09358449
5MP0005248_abnormal_Harderian_gland3.00839860
6MP0002736_abnormal_nociception_after2.94527722
7MP0002102_abnormal_ear_morphology2.58326080
8MP0006276_abnormal_autonomic_nervous2.52544743
9MP0002909_abnormal_adrenal_gland2.48291648
10MP0005671_abnormal_response_to2.33536382
11MP0005551_abnormal_eye_electrophysiolog2.15507527
12MP0008875_abnormal_xenobiotic_pharmacok2.15329040
13MP0001873_stomach_inflammation2.12136105
14MP0000613_abnormal_salivary_gland2.01261202
15MP0001501_abnormal_sleep_pattern1.90735361
16MP0002254_reproductive_system_inflammat1.88959146
17MP0008995_early_reproductive_senescence1.88952754
18MP0001968_abnormal_touch/_nociception1.79395380
19MP0005310_abnormal_salivary_gland1.73159564
20MP0001529_abnormal_vocalization1.71598515
21MP0005647_abnormal_sex_gland1.64473583
22MP0009333_abnormal_splenocyte_physiolog1.63938477
23MP0002733_abnormal_thermal_nociception1.57372880
24MP0003195_calcinosis1.52622954
25MP0010030_abnormal_orbit_morphology1.52348045
26MP0003787_abnormal_imprinting1.51371495
27MP0009764_decreased_sensitivity_to1.50515816
28MP0008961_abnormal_basal_metabolism1.49599162
29MP0001800_abnormal_humoral_immune1.49277152
30MP0008872_abnormal_physiological_respon1.41545546
31MP0005646_abnormal_pituitary_gland1.41392024
32MP0002735_abnormal_chemical_nociception1.40508754
33MP0001485_abnormal_pinna_reflex1.39644125
34MP0009785_altered_susceptibility_to1.39268974
35MP0004742_abnormal_vestibular_system1.38839049
36MP0003724_increased_susceptibility_to1.35880335
37MP0005000_abnormal_immune_tolerance1.34397470
38MP0002277_abnormal_respiratory_mucosa1.34335321
39MP0006082_CNS_inflammation1.32943464
40MP0003436_decreased_susceptibility_to1.31665405
41MP0002723_abnormal_immune_serum1.29481872
42MP0001970_abnormal_pain_threshold1.21095890
43MP0005025_abnormal_response_to1.20769798
44MP0002138_abnormal_hepatobiliary_system1.19907056
45MP0006292_abnormal_olfactory_placode1.19841452
46MP0009745_abnormal_behavioral_response1.19282271
47MP0002420_abnormal_adaptive_immunity1.19177329
48MP0000685_abnormal_immune_system1.18745855
49MP0001819_abnormal_immune_cell1.16653130
50MP0005266_abnormal_metabolism1.13685299
51MP0008874_decreased_physiological_sensi1.13544189
52MP0003122_maternal_imprinting1.13110779
53MP0002452_abnormal_antigen_presenting1.11946137
54MP0001881_abnormal_mammary_gland1.09224993
55MP0002419_abnormal_innate_immunity1.07315338
56MP0001919_abnormal_reproductive_system1.06878607
57MP0001905_abnormal_dopamine_level1.06096482
58MP0002163_abnormal_gland_morphology1.05598486
59MP0000631_abnormal_neuroendocrine_gland1.05097505
60MP0004043_abnormal_pH_regulation1.04605516
61MP0000026_abnormal_inner_ear1.04357579
62MP0002405_respiratory_system_inflammati1.03199091
63MP0002064_seizures1.01943157
64MP0001984_abnormal_olfaction1.00541565
65MP0003936_abnormal_reproductive_system0.98734887
66MP0009046_muscle_twitch0.98087385
67MP0002229_neurodegeneration0.97757535
68MP0001663_abnormal_digestive_system0.95370571
69MP0005387_immune_system_phenotype0.94496566
70MP0001790_abnormal_immune_system0.94496566
71MP0005174_abnormal_tail_pigmentation0.94337961
72MP0000716_abnormal_immune_system0.92936185
73MP0008789_abnormal_olfactory_epithelium0.92720738
74MP0003763_abnormal_thymus_physiology0.92690938
75MP0008260_abnormal_autophagy0.91498842
76MP0003011_delayed_dark_adaptation0.91479979
77MP0003959_abnormal_lean_body0.90595395
78MP0002272_abnormal_nervous_system0.89935355
79MP0002006_tumorigenesis0.88942426
80MP0000372_irregular_coat_pigmentation0.88911197
81MP0002876_abnormal_thyroid_physiology0.88424033
82MP0001346_abnormal_lacrimal_gland0.87296075
83MP0002752_abnormal_somatic_nervous0.85794323
84MP0003698_abnormal_male_reproductive0.85549269
85MP0002067_abnormal_sensory_capabilities0.84895787
86MP0001963_abnormal_hearing_physiology0.83664884
87MP0001835_abnormal_antigen_presentation0.83224854
88MP0002210_abnormal_sex_determination0.80740318
89MP0003635_abnormal_synaptic_transmissio0.80180838
90MP0005389_reproductive_system_phenotype0.78785336
91MP0000015_abnormal_ear_pigmentation0.76924243
92MP0001929_abnormal_gametogenesis0.75432544
93MP0002282_abnormal_trachea_morphology0.74866140
94MP0004924_abnormal_behavior0.73884927
95MP0005386_behavior/neurological_phenoty0.73884927
96MP0008873_increased_physiological_sensi0.73637688
97MP0005499_abnormal_olfactory_system0.72948824
98MP0005394_taste/olfaction_phenotype0.72948824
99MP0001486_abnormal_startle_reflex0.72339096
100MP0003283_abnormal_digestive_organ0.72191357

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)3.64187758
2Keratoconjunctivitis (HP:0001096)3.39911669
3Congenital sensorineural hearing impairment (HP:0008527)3.38471736
4Spastic paraparesis (HP:0002313)3.33377662
5Elevated erythrocyte sedimentation rate (HP:0003565)3.32883749
6Amyotrophic lateral sclerosis (HP:0007354)3.21400217
7Tubular atrophy (HP:0000092)3.15584163
8Congenital stationary night blindness (HP:0007642)3.15475362
9Hepatocellular necrosis (HP:0001404)3.13243212
10Mitochondrial inheritance (HP:0001427)3.10247010
11Severe visual impairment (HP:0001141)3.06262975
12Pancreatic cysts (HP:0001737)3.02003520
13Attenuation of retinal blood vessels (HP:0007843)3.00975482
14Acute encephalopathy (HP:0006846)2.92435286
15True hermaphroditism (HP:0010459)2.89203219
16Acute necrotizing encephalopathy (HP:0006965)2.86130268
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85917204
18Abnormality of alanine metabolism (HP:0010916)2.85917204
19Hyperalaninemia (HP:0003348)2.85917204
20Abnormal drinking behavior (HP:0030082)2.81567878
21Polydipsia (HP:0001959)2.81567878
22Hypoalbuminemia (HP:0003073)2.78325662
23Abnormal albumin level (HP:0012116)2.78325662
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.78158715
25Increased CSF lactate (HP:0002490)2.74308225
26Retinal atrophy (HP:0001105)2.69158558
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64484575
28Keratoconjunctivitis sicca (HP:0001097)2.63755479
29Aplastic anemia (HP:0001915)2.55016735
30Agammaglobulinemia (HP:0004432)2.54461488
31Pigmentary retinal degeneration (HP:0001146)2.53802160
32Abolished electroretinogram (ERG) (HP:0000550)2.52953484
33Abnormality of B cell number (HP:0010975)2.51811840
34Sensory axonal neuropathy (HP:0003390)2.50096724
35Abnormal mitochondria in muscle tissue (HP:0008316)2.49020829
36Retinal dysplasia (HP:0007973)2.46556963
37Tubulointerstitial fibrosis (HP:0005576)2.45880004
38Pancreatic fibrosis (HP:0100732)2.41581218
39Nephronophthisis (HP:0000090)2.38653803
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.36763256
41Retrobulbar optic neuritis (HP:0100654)2.36210901
42Optic neuritis (HP:0100653)2.36210901
43Orchitis (HP:0100796)2.33919220
44Abnormality of midbrain morphology (HP:0002418)2.33013754
45Molar tooth sign on MRI (HP:0002419)2.33013754
46B lymphocytopenia (HP:0010976)2.31083783
47Cerebral edema (HP:0002181)2.30247598
48Abnormal pancreas size (HP:0012094)2.30244684
49Hyperglycinemia (HP:0002154)2.29476218
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28599506
51Increased hepatocellular lipid droplets (HP:0006565)2.27655117
52Polyuria (HP:0000103)2.27629151
53Hepatic necrosis (HP:0002605)2.27355376
54Abnormality of glycine metabolism (HP:0010895)2.23534556
55Abnormality of serine family amino acid metabolism (HP:0010894)2.23534556
56Emotional lability (HP:0000712)2.18231240
57Myositis (HP:0100614)2.17265445
58Lipid accumulation in hepatocytes (HP:0006561)2.16247526
59Keratitis (HP:0000491)2.15624222
60Exertional dyspnea (HP:0002875)2.15480548
61Tinnitus (HP:0000360)2.15141160
62Progressive macrocephaly (HP:0004481)2.13970227
63Recurrent cutaneous fungal infections (HP:0011370)2.12840380
64Chronic mucocutaneous candidiasis (HP:0002728)2.12840380
65Abnormality of the renal medulla (HP:0100957)2.10802147
66Renal Fanconi syndrome (HP:0001994)2.10708069
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10597442
68Progressive microcephaly (HP:0000253)2.09311209
69Atrophy/Degeneration involving motor neurons (HP:0007373)2.08447987
70Recurrent corneal erosions (HP:0000495)2.05601778
71Short tibia (HP:0005736)2.03637850
72Opisthotonus (HP:0002179)2.02741841
73Slow saccadic eye movements (HP:0000514)2.02383199
74Stage 5 chronic kidney disease (HP:0003774)2.02259368
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01684244
76Periorbital edema (HP:0100539)2.00994131
773-Methylglutaconic aciduria (HP:0003535)1.99680852
78Facial edema (HP:0000282)1.96606686
79Increased neuronal autofluorescent lipopigment (HP:0002074)1.95150104
80Hyperglycinuria (HP:0003108)1.93356641
81Postaxial foot polydactyly (HP:0001830)1.92832206
82Gastrointestinal infarctions (HP:0005244)1.91669848
83Occipital encephalocele (HP:0002085)1.91021185
84Male pseudohermaphroditism (HP:0000037)1.90960424
85Inability to walk (HP:0002540)1.90194358
86Thrombocytosis (HP:0001894)1.90080977
87Cerebral hypomyelination (HP:0006808)1.89052639
88Recurrent pneumonia (HP:0006532)1.87633290
89Carpal bone hypoplasia (HP:0001498)1.86648888
90Abnormality of the renal cortex (HP:0011035)1.86482702
91Bony spicule pigmentary retinopathy (HP:0007737)1.86440821
92Abnormal gallbladder physiology (HP:0012438)1.85913424
93Cholecystitis (HP:0001082)1.85913424
94Cystic liver disease (HP:0006706)1.84894938
95Abnormal urine output (HP:0012590)1.83714683
96Lissencephaly (HP:0001339)1.83469894
97Decreased central vision (HP:0007663)1.80223695
98Absent/shortened dynein arms (HP:0200106)1.78648864
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.78648864
100Cerebellar dysplasia (HP:0007033)1.77896143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.35930882
2KDR4.74508278
3TESK24.69718290
4PIM23.81964893
5MAP4K22.64470950
6GRK62.63057416
7SIK22.61264167
8LIMK12.30088314
9TAOK32.29226464
10TESK12.25918198
11ARAF2.22113197
12MAP4K12.02104087
13NUAK11.90369859
14GRK11.82750068
15TXK1.72248670
16MAP3K111.67615849
17IRAK41.67482182
18MAP3K41.46622888
19FRK1.46128685
20MAP3K121.40061420
21INSRR1.36722758
22KIT1.36637690
23MAP3K91.36208183
24MAPKAPK31.33709520
25ADRBK21.31608821
26WNK31.30546838
27BLK1.29431578
28CAMKK21.22226494
29NME11.20377248
30ZAK1.20326264
31DAPK11.20019018
32EIF2AK31.11943042
33PINK11.10808989
34BMX1.04869736
35PRKD31.03025248
36MAP3K61.01142618
37VRK20.98925771
38RAF10.97348194
39SIK30.95986055
40SYK0.95945850
41TAOK10.93803449
42BRSK20.92900099
43GRK50.90164031
44MATK0.89707220
45IKBKE0.89207710
46DYRK1B0.85039927
47CDK190.80969642
48LYN0.77024717
49MAP3K50.76559402
50MAPKAPK50.75874157
51MAPK130.69739389
52PRKCQ0.68578326
53PIM10.67296834
54ADRBK10.66717342
55KSR10.66274714
56RPS6KA50.64038729
57MAP3K10.61885253
58DYRK20.61176955
59MAP3K20.60955727
60ABL20.60614395
61CCNB10.60014753
62PTK2B0.53022814
63NTRK30.52893841
64LMTK20.51435474
65PRKCH0.50820978
66BMPR1B0.49253665
67TAOK20.49021972
68CSNK1G30.47737917
69LCK0.46131801
70MAPKAPK20.45404476
71ITK0.45312225
72TYRO30.45198523
73CSF1R0.44734877
74CSNK1G20.43969893
75TEC0.43783306
76MARK30.41003260
77PASK0.40676634
78IRAK10.37206482
79IKBKB0.36017186
80TIE10.35876606
81CSNK1A1L0.34438608
82PRKD20.33547218
83CAMKK10.32498826
84PRKCI0.32055490
85LATS10.31562581
86BTK0.31412824
87CHEK20.30666774
88KSR20.30045631
89DAPK30.28412976
90INSR0.28113283
91TRIM280.27380971
92CAMK2B0.26540388
93IRAK30.26518059
94TGFBR10.25882445
95MAP2K70.25034421
96ATR0.24846635
97MAP3K30.24518414
98DDR20.23763270
99SCYL20.22402425
100PLK40.22350430

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.46446908
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.71959387
3Sulfur relay system_Homo sapiens_hsa041222.86188014
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54585217
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.47018240
6Nicotine addiction_Homo sapiens_hsa050332.45326798
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42058362
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.20009968
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04369148
10Phototransduction_Homo sapiens_hsa047442.02719083
11Graft-versus-host disease_Homo sapiens_hsa053322.02020319
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97819760
13Selenocompound metabolism_Homo sapiens_hsa004501.95848405
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90916922
15Oxidative phosphorylation_Homo sapiens_hsa001901.85841648
16Allograft rejection_Homo sapiens_hsa053301.73673104
17Parkinsons disease_Homo sapiens_hsa050121.68776198
18Autoimmune thyroid disease_Homo sapiens_hsa053201.60367633
19Base excision repair_Homo sapiens_hsa034101.47963640
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.46340260
21Linoleic acid metabolism_Homo sapiens_hsa005911.46206475
22Butanoate metabolism_Homo sapiens_hsa006501.44215362
23RNA polymerase_Homo sapiens_hsa030201.44065256
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42204599
25Fatty acid biosynthesis_Homo sapiens_hsa000611.42176574
26Antigen processing and presentation_Homo sapiens_hsa046121.38984990
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35541935
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34832883
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33317015
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26844516
31Taste transduction_Homo sapiens_hsa047421.20881225
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20217808
33Histidine metabolism_Homo sapiens_hsa003401.19177676
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.19069853
35Olfactory transduction_Homo sapiens_hsa047401.18829484
36Hematopoietic cell lineage_Homo sapiens_hsa046401.17896906
37Arachidonic acid metabolism_Homo sapiens_hsa005901.17224618
38Chemical carcinogenesis_Homo sapiens_hsa052041.16985608
39Huntingtons disease_Homo sapiens_hsa050161.14847777
40Nitrogen metabolism_Homo sapiens_hsa009101.12248059
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10915297
42Type I diabetes mellitus_Homo sapiens_hsa049401.10897631
43Morphine addiction_Homo sapiens_hsa050321.09684153
44Alzheimers disease_Homo sapiens_hsa050101.05346213
45Ribosome_Homo sapiens_hsa030101.03994105
46Pyrimidine metabolism_Homo sapiens_hsa002401.03864078
47Tryptophan metabolism_Homo sapiens_hsa003801.01019958
48Regulation of autophagy_Homo sapiens_hsa041400.98218192
49Purine metabolism_Homo sapiens_hsa002300.97969256
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.91453882
51Proteasome_Homo sapiens_hsa030500.88114538
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84693554
53T cell receptor signaling pathway_Homo sapiens_hsa046600.84443079
54Measles_Homo sapiens_hsa051620.79773605
55Glutathione metabolism_Homo sapiens_hsa004800.78518548
56Salivary secretion_Homo sapiens_hsa049700.74714742
57Dorso-ventral axis formation_Homo sapiens_hsa043200.73346752
58Calcium signaling pathway_Homo sapiens_hsa040200.73316633
59Glycerolipid metabolism_Homo sapiens_hsa005610.72518976
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.72283816
61Staphylococcus aureus infection_Homo sapiens_hsa051500.72021857
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.71324190
63Peroxisome_Homo sapiens_hsa041460.68435485
64Asthma_Homo sapiens_hsa053100.68285549
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65905455
66ABC transporters_Homo sapiens_hsa020100.65886867
67Cocaine addiction_Homo sapiens_hsa050300.63853172
68Ovarian steroidogenesis_Homo sapiens_hsa049130.62890749
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60374439
70Ether lipid metabolism_Homo sapiens_hsa005650.60356117
71Fanconi anemia pathway_Homo sapiens_hsa034600.59558506
72Sulfur metabolism_Homo sapiens_hsa009200.59333925
73Collecting duct acid secretion_Homo sapiens_hsa049660.58120461
74Tyrosine metabolism_Homo sapiens_hsa003500.58036664
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56731889
76GABAergic synapse_Homo sapiens_hsa047270.56220660
77Homologous recombination_Homo sapiens_hsa034400.55939094
78Cardiac muscle contraction_Homo sapiens_hsa042600.55253241
79Basal transcription factors_Homo sapiens_hsa030220.55181334
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54922869
81Propanoate metabolism_Homo sapiens_hsa006400.52153266
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51252402
83Viral myocarditis_Homo sapiens_hsa054160.51158625
84Serotonergic synapse_Homo sapiens_hsa047260.45943896
85Metabolic pathways_Homo sapiens_hsa011000.44765328
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42828537
87Systemic lupus erythematosus_Homo sapiens_hsa053220.39539464
88Malaria_Homo sapiens_hsa051440.39050318
89Phagosome_Homo sapiens_hsa041450.38325093
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37854173
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37017378
92Rheumatoid arthritis_Homo sapiens_hsa053230.36400914
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35936465
94Herpes simplex infection_Homo sapiens_hsa051680.34255475
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32895659
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32738219
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30701688
98Caffeine metabolism_Homo sapiens_hsa002320.28050445
99Oxytocin signaling pathway_Homo sapiens_hsa049210.27427310
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27159910

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