ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lipopolysaccharide biosynthetic process (GO:0009103)	9.47233998
2	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.11300771
3	protein-chromophore linkage (GO:0018298)	8.46268855
4	DNA methylation involved in gamete generation (GO:0043046)	8.38333390
5	lipopolysaccharide metabolic process (GO:0008653)	8.33929510
6	regulation of meiosis I (GO:0060631)	8.00608727
7	regulation of protein glycosylation (GO:0060049)	7.80459916
8	regulation of pigment cell differentiation (GO:0050932)	7.56258429
9	positive regulation of developmental pigmentation (GO:0048087)	7.39061523
10	sulfate transmembrane transport (GO:1902358)	7.34256712
11	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.33293385
12	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.18274777
13	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.75651955
14	paraxial mesoderm development (GO:0048339)	6.72240963
15	sulfate transport (GO:0008272)	6.34134931
16	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.26462835
17	piRNA metabolic process (GO:0034587)	5.86757502
18	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.54592038
19	L-phenylalanine catabolic process (GO:0006559)	5.54592038
20	notochord development (GO:0030903)	5.49052460
21	SMAD protein complex assembly (GO:0007183)	5.48998924
22	negative regulation of glycoprotein metabolic process (GO:1903019)	5.42451194
23	heme transport (GO:0015886)	4.97504225
24	tyrosine metabolic process (GO:0006570)	4.96322317
25	ribonucleoprotein complex disassembly (GO:0032988)	4.87940129
26	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.70007452
27	L-phenylalanine metabolic process (GO:0006558)	4.70007452
28	centriole replication (GO:0007099)	4.68976204
29	nodal signaling pathway (GO:0038092)	4.68195485
30	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.55358928
31	positive regulation of meiosis (GO:0045836)	4.51763487
32	meiotic chromosome segregation (GO:0045132)	4.51093176
33	regulation of interleukin-5 production (GO:0032674)	4.39945062
34	regulation of transforming growth factor beta2 production (GO:0032909)	4.33602501
35	response to mercury ion (GO:0046689)	4.22002399
36	negative regulation of stem cell proliferation (GO:2000647)	4.21454763
37	positive regulation of meiotic cell cycle (GO:0051446)	4.17692384
38	serotonin receptor signaling pathway (GO:0007210)	4.13825817
39	regulation of odontogenesis (GO:0042481)	4.02490553
40	cellular response to gamma radiation (GO:0071480)	3.96264144
41	vitamin transmembrane transport (GO:0035461)	3.95769775
42	glycerol metabolic process (GO:0006071)	3.95220039
43	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.94051222
44	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.90757699
45	organelle disassembly (GO:1903008)	3.87051094
46	response to epinephrine (GO:0071871)	3.85948917
47	germinal center formation (GO:0002467)	3.78150845
48	lysine catabolic process (GO:0006554)	3.77655785
49	lysine metabolic process (GO:0006553)	3.77655785
50	flavonoid metabolic process (GO:0009812)	3.76286352
51	pantothenate metabolic process (GO:0015939)	3.70684136
52	aspartate family amino acid catabolic process (GO:0009068)	3.70387839
53	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.68672934
54	regulation of developmental pigmentation (GO:0048070)	3.68528612
55	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.62452749
56	sulfur compound transport (GO:0072348)	3.61417778
57	toxin metabolic process (GO:0009404)	3.61252885
58	sympathetic nervous system development (GO:0048485)	3.58856362
59	aromatic amino acid family catabolic process (GO:0009074)	3.57929349
60	rhodopsin mediated signaling pathway (GO:0016056)	3.55506586
61	tachykinin receptor signaling pathway (GO:0007217)	3.53358908
62	iron coordination entity transport (GO:1901678)	3.53017972
63	DNA damage induced protein phosphorylation (GO:0006975)	3.49946098
64	alditol metabolic process (GO:0019400)	3.48039163
65	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.44369638
66	inflammatory response to antigenic stimulus (GO:0002437)	3.41715901
67	negative regulation of neural precursor cell proliferation (GO:2000178)	3.38959265
68	heart valve formation (GO:0003188)	3.37899133
69	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.37697923
70	regulation of keratinocyte proliferation (GO:0010837)	3.35195242
71	urate metabolic process (GO:0046415)	3.24458915
72	negative regulation of cell-matrix adhesion (GO:0001953)	3.23594322
73	protein retention in ER lumen (GO:0006621)	3.19351310
74	organ induction (GO:0001759)	3.15369413
75	embryonic process involved in female pregnancy (GO:0060136)	3.11488123
76	centriole assembly (GO:0098534)	3.10387080
77	aromatic amino acid family metabolic process (GO:0009072)	3.07339920
78	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.01041974
79	somite rostral/caudal axis specification (GO:0032525)	2.98103931
80	regulation of hair follicle development (GO:0051797)	2.92006164
81	membrane lipid biosynthetic process (GO:0046467)	2.88712855
82	sphingolipid biosynthetic process (GO:0030148)	2.84488100
83	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.84025509
84	uterus development (GO:0060065)	2.80929351
85	DNA methylation (GO:0006306)	2.78113037
86	DNA alkylation (GO:0006305)	2.78113037
87	biotin metabolic process (GO:0006768)	2.74675956
88	cofactor transport (GO:0051181)	2.72344069
89	polyol biosynthetic process (GO:0046173)	2.72227711
90	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.72097125
91	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.71098625
92	regulation of translational termination (GO:0006449)	2.68712970
93	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.67273625
94	generation of neurons (GO:0048699)	2.67044906
95	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.65727618
96	regulation of SMAD protein import into nucleus (GO:0060390)	2.65001029
97	negative regulation of BMP signaling pathway (GO:0030514)	2.64614756
98	sphingosine metabolic process (GO:0006670)	16.6553263
99	diol metabolic process (GO:0034311)	15.0664031
100	sphingoid metabolic process (GO:0046519)	13.4578440

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	4.96093104
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.60765516
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.24281272
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.20990246
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.98789779
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.77159565
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.75487986
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.73832801
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.61606069
10	P300_19829295_ChIP-Seq_ESCs_Human	2.30691240
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23305436
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14069936
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.94128010
14	VDR_22108803_ChIP-Seq_LS180_Human	1.92979888
15	EZH2_22144423_ChIP-Seq_EOC_Human	1.89503541
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87313072
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84745182
18	SOX2_19829295_ChIP-Seq_ESCs_Human	1.80163482
19	NANOG_19829295_ChIP-Seq_ESCs_Human	1.80163482
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79908434
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.79131226
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.76328856
23	STAT3_23295773_ChIP-Seq_U87_Human	1.71042630
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.69626456
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69012165
26	EGR1_19032775_ChIP-ChIP_M12_Human	1.68811868
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67823270
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.67823270
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66152479
30	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65085122
31	HOXB7_26014856_ChIP-Seq_BT474_Human	1.61822416
32	TCF4_23295773_ChIP-Seq_U87_Human	1.58613782
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56847837
34	AR_25329375_ChIP-Seq_VCAP_Human	1.56149619
35	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.54378593
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.50089441
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49780777
38	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.49284424
39	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.45733310
40	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.42955142
41	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.41195694
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38336440
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36645929
44	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.34882574
45	TP53_16413492_ChIP-PET_HCT116_Human	1.34487112
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33210795
47	STAT1_20625510_ChIP-Seq_HELA_Human	1.33095779
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31932372
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31465060
50	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.31275939
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30789279
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.30136048
53	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.29934309
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.28643091
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28257053
56	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.27517336
57	OCT4_20526341_ChIP-Seq_ESCs_Human	1.22801754
58	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22383029
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.21302514
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21102835
61	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.20110183
62	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18184868
63	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.17259576
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.15400425
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15363680
66	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.14839163
67	AR_19668381_ChIP-Seq_PC3_Human	1.14190569
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14181496
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13414417
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12235357
71	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11891982
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10266751
73	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.10197807
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09941087
75	NCOR_22424771_ChIP-Seq_293T_Human	1.09904338
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09551624
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09528727
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09007328
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09007328
80	TAF15_26573619_Chip-Seq_HEK293_Human	1.08883774
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08870687
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06588996
83	CBP_20019798_ChIP-Seq_JUKART_Human	1.06588996
84	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05950994
85	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.05645825
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05486593
87	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05232957
88	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.04009883
89	FUS_26573619_Chip-Seq_HEK293_Human	1.03713830
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03168836
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.02574378
92	CDX2_22108803_ChIP-Seq_LS180_Human	1.01689353
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00342427
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.98856816
95	CJUN_26792858_Chip-Seq_BT549_Human	0.98382004
96	CEBPB_22108803_ChIP-Seq_LS180_Human	0.98243487
97	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.97495828
98	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97140987
99	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.95362521
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95014866

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	8.94627911
2	MP0003136_yellow_coat_color	8.60089659
3	MP0005171_absent_coat_pigmentation	7.60976994
4	MP0002653_abnormal_ependyma_morphology	6.07041402
5	MP0003045_fibrosis	4.49141753
6	MP0003890_abnormal_embryonic-extraembry	4.24447768
7	MP0003646_muscle_fatigue	4.03894721
8	MP0003879_abnormal_hair_cell	3.11187520
9	MP0004381_abnormal_hair_follicle	2.91613964
10	MP0000569_abnormal_digit_pigmentation	2.89494140
11	MP0002138_abnormal_hepatobiliary_system	2.26398730
12	MP0005085_abnormal_gallbladder_physiolo	2.13245593
13	MP0005670_abnormal_white_adipose	2.11206511
14	MP0000749_muscle_degeneration	2.04491755
15	MP0002168_other_aberrant_phenotype	1.99947131
16	MP0005075_abnormal_melanosome_morpholog	1.98724310
17	MP0002938_white_spotting	1.81171143
18	MP0003705_abnormal_hypodermis_morpholog	1.72229890
19	MP0004147_increased_porphyrin_level	1.62359849
20	MP0003195_calcinosis	1.58956647
21	MP0002095_abnormal_skin_pigmentation	1.53499795
22	MP0005365_abnormal_bile_salt	1.51720618
23	MP0010352_gastrointestinal_tract_polyps	1.43862536
24	MP0002075_abnormal_coat/hair_pigmentati	1.19345812
25	MP0002254_reproductive_system_inflammat	1.18246948
26	MP0006054_spinal_hemorrhage	1.18197163
27	MP0005395_other_phenotype	1.16159357
28	MP0001984_abnormal_olfaction	1.10956747
29	MP0003137_abnormal_impulse_conducting	1.10854143
30	MP0005174_abnormal_tail_pigmentation	1.05368953
31	MP0000427_abnormal_hair_cycle	1.04802614
32	MP0004043_abnormal_pH_regulation	1.04381920
33	MP0002160_abnormal_reproductive_system	1.00969045
34	MP0004233_abnormal_muscle_weight	0.99369762
35	MP0005330_cardiomyopathy	0.90410117
36	MP0002269_muscular_atrophy	0.88267993
37	MP0000534_abnormal_ureter_morphology	0.83200208
38	MP0001501_abnormal_sleep_pattern	0.81994309
39	MP0001324_abnormal_eye_pigmentation	0.81338868
40	MP0001186_pigmentation_phenotype	0.80548978
41	MP0001661_extended_life_span	0.78496647
42	MP0002735_abnormal_chemical_nociception	0.74594097
43	MP0003252_abnormal_bile_duct	0.69096848
44	MP0001486_abnormal_startle_reflex	0.68297046
45	MP0003300_gastrointestinal_ulcer	0.65737252
46	MP0002876_abnormal_thyroid_physiology	0.64650340
47	MP0003950_abnormal_plasma_membrane	0.62742858
48	MP0005319_abnormal_enzyme/_coenzyme	0.60004742
49	MP0005551_abnormal_eye_electrophysiolog	0.59350455
50	MP0002751_abnormal_autonomic_nervous	0.58733084
51	MP0008770_decreased_survivor_rate	0.58073232
52	MP0002396_abnormal_hematopoietic_system	0.57537698
53	MP0002272_abnormal_nervous_system	0.56044052
54	MP0002332_abnormal_exercise_endurance	0.55989705
55	MP0000015_abnormal_ear_pigmentation	0.55462484
56	MP0002971_abnormal_brown_adipose	0.55042982
57	MP0009764_decreased_sensitivity_to	0.53360181
58	MP0008875_abnormal_xenobiotic_pharmacok	0.52988591
59	MP0005377_hearing/vestibular/ear_phenot	0.52816895
60	MP0003878_abnormal_ear_physiology	0.52816895
61	MP0008569_lethality_at_weaning	0.52605038
62	MP0009115_abnormal_fat_cell	0.50799737
63	MP0005389_reproductive_system_phenotype	0.50166008
64	MP0001970_abnormal_pain_threshold	0.48632377
65	MP0004130_abnormal_muscle_cell	0.48629659
66	MP0005410_abnormal_fertilization	0.46070801
67	MP0002277_abnormal_respiratory_mucosa	0.45940278
68	MP0005076_abnormal_cell_differentiation	0.45841135
69	MP0009745_abnormal_behavioral_response	0.42719522
70	MP0002229_neurodegeneration	0.42039355
71	MP0004142_abnormal_muscle_tone	0.40454368
72	MP0009046_muscle_twitch	0.39648702
73	MP0003632_abnormal_nervous_system	0.38322433
74	MP0003937_abnormal_limbs/digits/tail_de	0.36255012
75	MP0002928_abnormal_bile_duct	0.35844941
76	MP0005253_abnormal_eye_physiology	0.35074036
77	MP0010307_abnormal_tumor_latency	0.34927089
78	MP0008872_abnormal_physiological_respon	0.34253990
79	MP0004484_altered_response_of	0.33898246
80	MP0003959_abnormal_lean_body	0.33754234
81	MP0005248_abnormal_Harderian_gland	0.33139335
82	MP0002572_abnormal_emotion/affect_behav	0.32474010
83	MP0002064_seizures	0.32471016
84	MP0002102_abnormal_ear_morphology	0.32050855
85	MP0010030_abnormal_orbit_morphology	0.31731292
86	MP0000383_abnormal_hair_follicle	0.31290133
87	MP0003763_abnormal_thymus_physiology	0.29995568
88	MP0000026_abnormal_inner_ear	0.29952547
89	MP0008874_decreased_physiological_sensi	0.28956906
90	MP0005266_abnormal_metabolism	0.28522210
91	MP0000377_abnormal_hair_follicle	0.27601800
92	MP0002733_abnormal_thermal_nociception	0.27389032
93	MP0001800_abnormal_humoral_immune	0.24644271
94	MP0005448_abnormal_energy_balance	0.23802068
95	MP0001986_abnormal_taste_sensitivity	0.22435769
96	MP0001968_abnormal_touch/_nociception	0.21679123
97	MP0000778_abnormal_nervous_system	0.21659591
98	MP0003941_abnormal_skin_development	0.21212885
99	MP0005387_immune_system_phenotype	0.20865791
100	MP0001790_abnormal_immune_system	0.20865791

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	9.79301097
2	Focal motor seizures (HP:0011153)	9.67720228
3	Acanthocytosis (HP:0001927)	7.31567615
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.17477717
5	Parakeratosis (HP:0001036)	6.96006147
6	Aplastic anemia (HP:0001915)	5.59147483
7	Dialeptic seizures (HP:0011146)	4.91446578
8	Proximal amyotrophy (HP:0007126)	4.78621700
9	Pancreatic cysts (HP:0001737)	4.50377584
10	Colon cancer (HP:0003003)	4.14515949
11	Congenital ichthyosiform erythroderma (HP:0007431)	4.06266963
12	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.01728962
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.00325840
14	Focal seizures (HP:0007359)	3.90314242
15	Spontaneous hematomas (HP:0007420)	3.78282405
16	Rectal prolapse (HP:0002035)	3.77327863
17	Vertebral arch anomaly (HP:0008438)	3.74420423
18	Hematochezia (HP:0002573)	3.69612191
19	Difficulty walking (HP:0002355)	3.66811950
20	Scapular winging (HP:0003691)	3.58983048
21	Ulnar claw (HP:0001178)	3.38072962
22	Erythroderma (HP:0001019)	3.33279174
23	Abnormality of the renal cortex (HP:0011035)	3.21521729
24	Potter facies (HP:0002009)	3.16428267
25	Facial shape deformation (HP:0011334)	3.16428267
26	Poikilocytosis (HP:0004447)	3.15141202
27	Conjunctival telangiectasia (HP:0000524)	3.03484843
28	Esophageal varix (HP:0002040)	3.02775673
29	Overlapping toe (HP:0001845)	2.97205318
30	Ulnar bowing (HP:0003031)	2.96626997
31	Bilateral sensorineural hearing impairment (HP:0008619)	2.92349226
32	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.91114054
33	Progressive inability to walk (HP:0002505)	2.79891811
34	IgM deficiency (HP:0002850)	2.73209145
35	Radial bowing (HP:0002986)	2.73148462
36	Synostosis of carpal bones (HP:0005048)	2.69853193
37	Abnormality of the vocal cords (HP:0008777)	2.69132353
38	Abnormality of the renal medulla (HP:0100957)	2.68154306
39	Enlarged kidneys (HP:0000105)	2.58688613
40	Portal hypertension (HP:0001409)	2.54773224
41	Pendular nystagmus (HP:0012043)	2.50341433
42	Decreased circulating renin level (HP:0003351)	2.50060405
43	Cystic liver disease (HP:0006706)	2.49949823
44	Petechiae (HP:0000967)	2.39842860
45	Recurrent sinusitis (HP:0011108)	2.38769959
46	Autoimmune hemolytic anemia (HP:0001890)	2.37020689
47	Abnormality of macular pigmentation (HP:0008002)	2.35944832
48	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.35626022
49	Broad ribs (HP:0000885)	2.34548621
50	Abnormality of the hepatic vasculature (HP:0006707)	2.30604374
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30409512
52	Absent/shortened dynein arms (HP:0200106)	2.30409512
53	Hypoplastic iliac wings (HP:0002866)	2.28708778
54	Severe visual impairment (HP:0001141)	2.28707250
55	Tubulointerstitial fibrosis (HP:0005576)	2.28466872
56	Tubular atrophy (HP:0000092)	2.27426935
57	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.26747318
58	Nephronophthisis (HP:0000090)	2.26287855
59	Pancreatic fibrosis (HP:0100732)	2.24959625
60	Tarsal synostosis (HP:0008368)	2.22598640
61	Gangrene (HP:0100758)	2.20038914
62	Albinism (HP:0001022)	2.18548092
63	Abnormality of the shoulder girdle musculature (HP:0001435)	2.14220351
64	Lack of skin elasticity (HP:0100679)	2.14026574
65	Hypokalemia (HP:0002900)	2.13573643
66	Type I transferrin isoform profile (HP:0003642)	2.12134511
67	Abnormal pancreas size (HP:0012094)	2.12001282
68	Chronic hepatic failure (HP:0100626)	2.07936096
69	Retinitis pigmentosa (HP:0000510)	2.06546028
70	Synostosis involving bones of the feet (HP:0009140)	2.06211132
71	Synostosis involving bones of the lower limbs (HP:0009138)	2.06211132
72	Cerebellar dysplasia (HP:0007033)	2.05673819
73	Inability to walk (HP:0002540)	1.99865778
74	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.99594587
75	Stomach cancer (HP:0012126)	1.99475511
76	Dehydration (HP:0001944)	1.97052354
77	Opisthotonus (HP:0002179)	1.92057386
78	Type II lissencephaly (HP:0007260)	1.90378057
79	Abnormality of potassium homeostasis (HP:0011042)	1.89994800
80	Abnormal ciliary motility (HP:0012262)	1.89018210
81	Colitis (HP:0002583)	1.87476553
82	Neoplasm of the small intestine (HP:0100833)	1.86306647
83	Chronic diarrhea (HP:0002028)	1.85432160
84	Peripheral hypomyelination (HP:0007182)	1.83292823
85	Abnormal albumin level (HP:0012116)	1.81218878
86	Hypoalbuminemia (HP:0003073)	1.81218878
87	Visceral angiomatosis (HP:0100761)	1.79013776
88	Congenital hepatic fibrosis (HP:0002612)	1.76915738
89	Tubulointerstitial abnormality (HP:0001969)	1.76314768
90	Bronchiectasis (HP:0002110)	1.76065438
91	Gastrointestinal stroma tumor (HP:0100723)	1.74216406
92	Thickened calvaria (HP:0002684)	1.72965724
93	True hermaphroditism (HP:0010459)	1.72307978
94	Epidermoid cyst (HP:0200040)	1.70940911
95	Carpal bone hypoplasia (HP:0001498)	1.69757531
96	Ulnar deviation of finger (HP:0009465)	1.69701187
97	Pancytopenia (HP:0001876)	1.69577635
98	Palmoplantar keratoderma (HP:0000982)	1.69107336
99	Hemangiomatosis (HP:0007461)	1.68859430
100	Abnormality of the fingertips (HP:0001211)	1.68356316

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.31342937
2	LATS2	6.57388691
3	PRKD3	2.84892807
4	STK38	2.81918333
5	ACVR1B	2.78009636
6	FRK	2.64600402
7	ZAK	2.55811841
8	NLK	2.49472601
9	STK3	2.05404654
10	MAP2K2	2.04677765
11	LATS1	10.7738565
12	BMPR1B	1.99859435
13	MELK	1.96686129
14	MAP3K2	1.30750363
15	PIK3CG	1.17418911
16	EIF2AK3	1.02295099
17	PINK1	1.00996690
18	PDK2	1.00837476
19	PDPK1	0.99786918
20	NEK2	0.96647100
21	PRKAA2	0.95656577
22	TGFBR1	0.94565880
23	TAF1	0.92805245
24	KSR2	0.92563888
25	GRK7	0.85669532
26	IRAK3	0.84425455
27	TGFBR2	0.74723172
28	CSNK1A1L	0.69108384
29	NEK9	0.65164437
30	PRKD1	0.58135450
31	ADRBK2	0.57851078
32	ADRBK1	0.56135486
33	MOS	0.49896776
34	TTK	0.48515521
35	DAPK2	0.48217253
36	NEK6	0.43824151
37	WNK4	0.41255186
38	STK10	0.38767890
39	GRK5	0.36894974
40	STK11	0.35862590
41	NME1	0.35027550
42	MAP2K1	0.34699577
43	WNK3	0.29541011
44	MST1R	0.29348165
45	TNK2	0.28344825
46	PIM1	0.28284601
47	PLK1	0.25169835
48	TRIM28	0.23433555
49	MET	0.20920664
50	STK39	0.20596129
51	PRKCI	0.18765026
52	CSNK1D	0.17538463
53	TAOK3	0.16954500
54	PTK2B	0.14886935
55	ABL1	0.14832099
56	TXK	0.14095807
57	MAP3K7	0.13465275
58	MKNK2	0.12012965
59	NEK1	0.11840508
60	MAPK7	0.11481103
61	MAPK3	0.10737143
62	AKT2	0.10717259
63	CHEK2	0.10268109
64	OXSR1	0.09510564
65	PRKCE	0.09407593
66	TEC	0.09151165
67	EIF2AK2	0.09004458
68	CDK3	0.08491999
69	ITK	0.07451403
70	PRKACA	0.06586572
71	MARK1	0.06376816
72	GRK1	0.05307394
73	FER	0.05114212
74	MAPK15	0.04520200
75	MAPK1	0.04436222
76	NTRK2	0.03829731
77	MAP4K2	0.03550603
78	JAK2	0.03498756
79	IRAK4	0.03374639
80	CAMK2B	0.02998012
81	PDK1	0.02345688
82	RET	0.01544184
83	MAP3K1	0.00774199
84	CAMK2A	0.00213337
85	IGF1R	-0.0673173
86	STK24	-0.0626723
87	GSK3B	-0.0614220
88	ATR	-0.0607155
89	PLK2	-0.0579738
90	PIK3CA	-0.0577939
91	PRKCB	-0.0568948
92	MKNK1	-0.0544519
93	BRSK2	-0.0499340
94	CSNK1A1	-0.0496896
95	CDK5	-0.0368839
96	CSNK1G2	-0.0327721
97	TRPM7	-0.0311611
98	PRKCG	-0.0193850
99	MAPK8	-0.0160092
100	PRKACB	-0.0042125

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.47476074
2	Phototransduction_Homo sapiens_hsa04744	4.52149637
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.98365258
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.93227041
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.38449763
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.81640789
7	Nicotine addiction_Homo sapiens_hsa05033	2.73233451
8	Taste transduction_Homo sapiens_hsa04742	2.18323283
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.99461716
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.95528099
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.92844315
12	Morphine addiction_Homo sapiens_hsa05032	1.79597375
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.71566115
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.55851945
15	Histidine metabolism_Homo sapiens_hsa00340	1.55192142
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54254550
17	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.42783234
18	GABAergic synapse_Homo sapiens_hsa04727	1.30449289
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25037135
20	Calcium signaling pathway_Homo sapiens_hsa04020	1.24526857
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21018343
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19817696
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18866766
24	One carbon pool by folate_Homo sapiens_hsa00670	1.18810411
25	ABC transporters_Homo sapiens_hsa02010	1.15043333
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.13069577
27	Viral myocarditis_Homo sapiens_hsa05416	1.08298711
28	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.02509842
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01640745
30	Butanoate metabolism_Homo sapiens_hsa00650	1.00573354
31	Basal transcription factors_Homo sapiens_hsa03022	0.94480389
32	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.93338029
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90546904
34	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.88375996
35	Tyrosine metabolism_Homo sapiens_hsa00350	0.85142637
36	Lysine degradation_Homo sapiens_hsa00310	0.84282887
37	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84267595
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.81090537
39	Bile secretion_Homo sapiens_hsa04976	0.80919455
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80675915
41	VEGF signaling pathway_Homo sapiens_hsa04370	0.78994542
42	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75693232
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75046318
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.71496354
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.70260489
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.68147317
47	Serotonergic synapse_Homo sapiens_hsa04726	0.67021469
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65659585
49	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.65568809
50	Colorectal cancer_Homo sapiens_hsa05210	0.64479481
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64194167
52	Adherens junction_Homo sapiens_hsa04520	0.61647575
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61048612
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61018883
55	Fatty acid degradation_Homo sapiens_hsa00071	0.59891205
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59286970
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.58306580
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.57342592
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.55763469
60	Olfactory transduction_Homo sapiens_hsa04740	0.51592499
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50681649
62	ECM-receptor interaction_Homo sapiens_hsa04512	0.48863258
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48696655
64	Homologous recombination_Homo sapiens_hsa03440	0.46197566
65	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.44838796
66	Salivary secretion_Homo sapiens_hsa04970	0.44825987
67	Retinol metabolism_Homo sapiens_hsa00830	0.41294523
68	African trypanosomiasis_Homo sapiens_hsa05143	0.39278535
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38866599
70	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.35096390
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.34600380
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.33551492
73	Thyroid cancer_Homo sapiens_hsa05216	0.30809887
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.30182504
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.27460388
76	Tuberculosis_Homo sapiens_hsa05152	0.27294101
77	Oocyte meiosis_Homo sapiens_hsa04114	0.27272327
78	Propanoate metabolism_Homo sapiens_hsa00640	0.26670459
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.25719714
80	Melanogenesis_Homo sapiens_hsa04916	0.25673649
81	Gastric acid secretion_Homo sapiens_hsa04971	0.24680154
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23997444
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23626896
84	Circadian entrainment_Homo sapiens_hsa04713	0.23256892
85	Insulin secretion_Homo sapiens_hsa04911	0.23044166
86	Cell cycle_Homo sapiens_hsa04110	0.22761999
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.21477273
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.21449378
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.20816507
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.20788848
91	Linoleic acid metabolism_Homo sapiens_hsa00591	0.20708953
92	Pancreatic cancer_Homo sapiens_hsa05212	0.20290142
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19425229
94	Peroxisome_Homo sapiens_hsa04146	0.18864198
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.17842625
96	Folate biosynthesis_Homo sapiens_hsa00790	0.17386666
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.15036828
98	Metabolic pathways_Homo sapiens_hsa01100	0.14760529
99	Asthma_Homo sapiens_hsa05310	0.11272661
100	Estrogen signaling pathway_Homo sapiens_hsa04915	0.07755662

DUXAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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