ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.38767384
2	homocysteine metabolic process (GO:0050667)	4.79206334
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.49193099
4	cullin deneddylation (GO:0010388)	4.30887106
5	protein deneddylation (GO:0000338)	3.91791943
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.91015211
7	NADH dehydrogenase complex assembly (GO:0010257)	3.91015211
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.91015211
9	superoxide anion generation (GO:0042554)	3.88690489
10	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.80021833
11	response to pheromone (GO:0019236)	3.76604268
12	protein complex biogenesis (GO:0070271)	3.74181460
13	detection of light stimulus involved in visual perception (GO:0050908)	3.67214739
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.67214739
15	L-fucose catabolic process (GO:0042355)	3.65421767
16	fucose catabolic process (GO:0019317)	3.65421767
17	L-fucose metabolic process (GO:0042354)	3.65421767
18	rRNA catabolic process (GO:0016075)	3.63738616
19	regulation of mitochondrial translation (GO:0070129)	3.48056074
20	indolalkylamine metabolic process (GO:0006586)	3.43800628
21	respiratory chain complex IV assembly (GO:0008535)	3.40573156
22	negative regulation of telomere maintenance (GO:0032205)	3.36865146
23	cornea development in camera-type eye (GO:0061303)	3.34650443
24	C4-dicarboxylate transport (GO:0015740)	3.31724892
25	kynurenine metabolic process (GO:0070189)	3.28894120
26	tryptophan catabolic process (GO:0006569)	3.25671093
27	indole-containing compound catabolic process (GO:0042436)	3.25671093
28	indolalkylamine catabolic process (GO:0046218)	3.25671093
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.24608412
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.21197729
31	metallo-sulfur cluster assembly (GO:0031163)	3.14045160
32	iron-sulfur cluster assembly (GO:0016226)	3.14045160
33	synaptic transmission, cholinergic (GO:0007271)	3.13071790
34	intraciliary transport (GO:0042073)	3.02171964
35	DNA deamination (GO:0045006)	3.00890266
36	proline transport (GO:0015824)	3.00077812
37	cellular response to gamma radiation (GO:0071480)	2.99014465
38	transepithelial transport (GO:0070633)	2.96285292
39	protein localization to cilium (GO:0061512)	2.94345018
40	cellular ketone body metabolic process (GO:0046950)	2.93576345
41	cytochrome complex assembly (GO:0017004)	2.92694672
42	relaxation of smooth muscle (GO:0044557)	2.91400759
43	auditory receptor cell stereocilium organization (GO:0060088)	2.91005228
44	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.85717101
45	L-ascorbic acid metabolic process (GO:0019852)	2.85264460
46	pseudouridine synthesis (GO:0001522)	2.83233124
47	multicellular organism reproduction (GO:0032504)	2.79162702
48	cilium organization (GO:0044782)	2.76382814
49	protein K11-linked deubiquitination (GO:0035871)	2.75840617
50	glycerophospholipid catabolic process (GO:0046475)	2.75326280
51	ketone body metabolic process (GO:1902224)	2.75052595
52	photoreceptor cell development (GO:0042461)	2.74143478
53	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.74042129
54	photoreceptor cell maintenance (GO:0045494)	2.72980673
55	neural tube formation (GO:0001841)	2.72882582
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.71459402
57	cilium assembly (GO:0042384)	2.70441183
58	positive regulation of smooth muscle cell migration (GO:0014911)	2.69624105
59	mannosylation (GO:0097502)	2.69316251
60	positive regulation of histone H3-K4 methylation (GO:0051571)	2.69286124
61	adaptation of signaling pathway (GO:0023058)	2.69214801
62	neuronal action potential (GO:0019228)	2.69131094
63	adult feeding behavior (GO:0008343)	2.67965661
64	piRNA metabolic process (GO:0034587)	2.65357638
65	regulation of hexokinase activity (GO:1903299)	2.65295020
66	regulation of glucokinase activity (GO:0033131)	2.65295020
67	protein-cofactor linkage (GO:0018065)	2.64317829
68	tryptophan metabolic process (GO:0006568)	2.63655879
69	ubiquinone biosynthetic process (GO:0006744)	2.63514820
70	regulation of acrosome reaction (GO:0060046)	2.60506748
71	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.60483049
72	double-strand break repair via homologous recombination (GO:0000724)	2.60033285
73	recombinational repair (GO:0000725)	2.59085154
74	protein K6-linked ubiquitination (GO:0085020)	2.58843941
75	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.54129324
76	tRNA modification (GO:0006400)	2.54053070
77	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.53234109
78	spinal cord motor neuron differentiation (GO:0021522)	2.52982166
79	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.51988543
80	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51678743
81	inner ear receptor stereocilium organization (GO:0060122)	2.51585825
82	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50916502
83	DNA methylation involved in gamete generation (GO:0043046)	2.50831466
84	reciprocal DNA recombination (GO:0035825)	2.50712027
85	reciprocal meiotic recombination (GO:0007131)	2.50712027
86	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.49187751
87	neuron fate determination (GO:0048664)	2.48002559
88	peptidyl-histidine modification (GO:0018202)	2.47795017
89	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.46806510
90	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.46266895
91	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.45638786
92	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.45549241
93	tRNA processing (GO:0008033)	2.45050242
94	response to nitrosative stress (GO:0051409)	2.44702698
95	prenylation (GO:0097354)	2.44089353
96	protein prenylation (GO:0018342)	2.44089353
97	sphingoid metabolic process (GO:0046519)	2.43763801
98	cilium morphogenesis (GO:0060271)	2.43032362
99	indole-containing compound metabolic process (GO:0042430)	2.42808839
100	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.42413423

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.04790739
2	VDR_22108803_ChIP-Seq_LS180_Human	3.18910657
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81328299
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.77125665
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.68112673
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.64338843
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47443800
8	EWS_26573619_Chip-Seq_HEK293_Human	2.42508208
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38985548
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.34592903
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31871670
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.11757135
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06699457
14	FUS_26573619_Chip-Seq_HEK293_Human	2.06613512
15	P300_19829295_ChIP-Seq_ESCs_Human	1.99948093
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95909112
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94822048
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93383489
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83962017
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.82888241
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82167756
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79022696
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76322566
24	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.70685672
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67429919
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65454696
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.65387415
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64741235
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60776030
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.58878678
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57827929
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57562242
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55691226
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.55537936
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54598773
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52506193
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48492112
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48362096
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47008484
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46474963
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.43597972
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43597972
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43366085
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40679300
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.40522799
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.40001210
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39914771
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37609458
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37609458
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.35962412
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35617979
52	TCF4_23295773_ChIP-Seq_U87_Human	1.35487619
53	AR_25329375_ChIP-Seq_VCAP_Human	1.33723656
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31245006
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30919336
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30811492
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29663624
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28958120
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26074055
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25938755
61	STAT3_23295773_ChIP-Seq_U87_Human	1.24843653
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.23820202
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23804838
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21157725
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20780427
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20780427
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20722224
68	NCOR_22424771_ChIP-Seq_293T_Human	1.19650490
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18260067
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.17125914
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16529799
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16495110
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15107787
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15082669
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14116037
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.12949352
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11673612
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11008320
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10207790
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.09938366
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09663591
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09344477
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09166641
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09166641
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08769925
86	AR_20517297_ChIP-Seq_VCAP_Human	1.08361756
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08351555
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07516373
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05272067
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02878632
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02417146
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00871989
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00458430
94	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99940928
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99469544
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.98957684
97	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98318907
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.98198797
99	VDR_23849224_ChIP-Seq_CD4+_Human	0.98110605
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97832455

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.37267777
2	MP0003195_calcinosis	2.94433998
3	MP0005551_abnormal_eye_electrophysiolog	2.90701642
4	MP0003787_abnormal_imprinting	2.76931861
5	MP0008877_abnormal_DNA_methylation	2.70112083
6	MP0002638_abnormal_pupillary_reflex	2.51218277
7	MP0010386_abnormal_urinary_bladder	2.19074548
8	MP0005084_abnormal_gallbladder_morpholo	2.15287186
9	MP0002837_dystrophic_cardiac_calcinosis	2.11895627
10	MP0002876_abnormal_thyroid_physiology	2.10641808
11	MP0001968_abnormal_touch/_nociception	2.03104355
12	MP0005379_endocrine/exocrine_gland_phen	2.01639122
13	MP0005360_urolithiasis	1.95044257
14	MP0005253_abnormal_eye_physiology	1.93430610
15	MP0003646_muscle_fatigue	1.86657351
16	MP0006072_abnormal_retinal_apoptosis	1.85411175
17	MP0003183_abnormal_peptide_metabolism	1.84789485
18	MP0006276_abnormal_autonomic_nervous	1.81190845
19	MP0002736_abnormal_nociception_after	1.80655541
20	MP0009697_abnormal_copulation	1.80587960
21	MP0000427_abnormal_hair_cycle	1.78183904
22	MP0008872_abnormal_physiological_respon	1.67596448
23	MP0009046_muscle_twitch	1.62777321
24	MP0001986_abnormal_taste_sensitivity	1.60484729
25	MP0002163_abnormal_gland_morphology	1.59926178
26	MP0003880_abnormal_central_pattern	1.59553486
27	MP0004142_abnormal_muscle_tone	1.58999596
28	MP0001485_abnormal_pinna_reflex	1.57899480
29	MP0009745_abnormal_behavioral_response	1.55844596
30	MP0002735_abnormal_chemical_nociception	1.55800052
31	MP0005645_abnormal_hypothalamus_physiol	1.53309525
32	MP0005646_abnormal_pituitary_gland	1.52491720
33	MP0003011_delayed_dark_adaptation	1.51833820
34	MP0006292_abnormal_olfactory_placode	1.51503119
35	MP0004885_abnormal_endolymph	1.47172905
36	MP0001502_abnormal_circadian_rhythm	1.45917421
37	MP0004145_abnormal_muscle_electrophysio	1.43494023
38	MP0003786_premature_aging	1.43048179
39	MP0004133_heterotaxia	1.40451654
40	MP0003186_abnormal_redox_activity	1.38265929
41	MP0002095_abnormal_skin_pigmentation	1.34933398
42	MP0002272_abnormal_nervous_system	1.30548385
43	MP0002234_abnormal_pharynx_morphology	1.29473745
44	MP0008995_early_reproductive_senescence	1.27707704
45	MP0008875_abnormal_xenobiotic_pharmacok	1.26600948
46	MP0001501_abnormal_sleep_pattern	1.25980711
47	MP0000372_irregular_coat_pigmentation	1.25935561
48	MP0008058_abnormal_DNA_repair	1.25294301
49	MP0001984_abnormal_olfaction	1.25081233
50	MP0005365_abnormal_bile_salt	1.23730266
51	MP0006036_abnormal_mitochondrial_physio	1.23465836
52	MP0009764_decreased_sensitivity_to	1.22926108
53	MP0000647_abnormal_sebaceous_gland	1.22738736
54	MP0002938_white_spotting	1.21448693
55	MP0001486_abnormal_startle_reflex	1.20283846
56	MP0001970_abnormal_pain_threshold	1.20280244
57	MP0000569_abnormal_digit_pigmentation	1.16142045
58	MP0004043_abnormal_pH_regulation	1.15775906
59	MP0005195_abnormal_posterior_eye	1.15282301
60	MP0002733_abnormal_thermal_nociception	1.11838804
61	MP0002928_abnormal_bile_duct	1.09141503
62	MP0003121_genomic_imprinting	1.08485230
63	MP0002557_abnormal_social/conspecific_i	1.06402151
64	MP0005389_reproductive_system_phenotype	1.06105171
65	MP0002160_abnormal_reproductive_system	1.03719032
66	MP0009780_abnormal_chondrocyte_physiolo	1.02857394
67	MP0005499_abnormal_olfactory_system	1.01125971
68	MP0005394_taste/olfaction_phenotype	1.01125971
69	MP0000538_abnormal_urinary_bladder	1.00774462
70	MP0000631_abnormal_neuroendocrine_gland	0.99505368
71	MP0004019_abnormal_vitamin_homeostasis	0.99272581
72	MP0002572_abnormal_emotion/affect_behav	0.98825201
73	MP0004742_abnormal_vestibular_system	0.98578396
74	MP0002064_seizures	0.96778705
75	MP0004484_altered_response_of	0.95765609
76	MP0002734_abnormal_mechanical_nocicepti	0.95306028
77	MP0010094_abnormal_chromosome_stability	0.95068813
78	MP0003122_maternal_imprinting	0.94822785
79	MP0003119_abnormal_digestive_system	0.94493412
80	MP0002277_abnormal_respiratory_mucosa	0.94275814
81	MP0002752_abnormal_somatic_nervous	0.93616004
82	MP0003698_abnormal_male_reproductive	0.93228624
83	MP0001963_abnormal_hearing_physiology	0.92334904
84	MP0000049_abnormal_middle_ear	0.92053083
85	MP0000383_abnormal_hair_follicle	0.91828786
86	MP0002229_neurodegeneration	0.91506570
87	MP0001756_abnormal_urination	0.91386746
88	MP0003950_abnormal_plasma_membrane	0.91365853
89	MP0001919_abnormal_reproductive_system	0.89729330
90	MP0003693_abnormal_embryo_hatching	0.87783095
91	MP0001905_abnormal_dopamine_level	0.87569359
92	MP0002653_abnormal_ependyma_morphology	0.87208170
93	MP0000026_abnormal_inner_ear	0.87167534
94	MP0010329_abnormal_lipoprotein_level	0.86646449
95	MP0001929_abnormal_gametogenesis	0.83532055
96	MP0001324_abnormal_eye_pigmentation	0.81675625
97	MP0002751_abnormal_autonomic_nervous	0.80216364
98	MP0002693_abnormal_pancreas_physiology	0.79102347
99	MP0005386_behavior/neurological_phenoty	0.78810668
100	MP0004924_abnormal_behavior	0.78810668

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	4.79885362
2	Pancreatic cysts (HP:0001737)	4.05715501
3	Molar tooth sign on MRI (HP:0002419)	3.96100290
4	Abnormality of midbrain morphology (HP:0002418)	3.96100290
5	Abolished electroretinogram (ERG) (HP:0000550)	3.89414342
6	Type II lissencephaly (HP:0007260)	3.86992606
7	Congenital stationary night blindness (HP:0007642)	3.79730125
8	Increased corneal curvature (HP:0100692)	3.73207964
9	Keratoconus (HP:0000563)	3.73207964
10	Chorioretinal atrophy (HP:0000533)	3.64577563
11	Pancreatic fibrosis (HP:0100732)	3.49078588
12	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.28804822
13	Hypoplasia of the fovea (HP:0007750)	3.28804822
14	True hermaphroditism (HP:0010459)	3.25641236
15	Nephronophthisis (HP:0000090)	3.03007451
16	Acute necrotizing encephalopathy (HP:0006965)	2.98626672
17	Fibular aplasia (HP:0002990)	2.98061279
18	Attenuation of retinal blood vessels (HP:0007843)	2.93141107
19	Lissencephaly (HP:0001339)	2.82901093
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.76072364
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.71007450
22	Abnormality of the fovea (HP:0000493)	2.68527185
23	Acute encephalopathy (HP:0006846)	2.67944439
24	Unilateral renal agenesis (HP:0000122)	2.67869292
25	Progressive macrocephaly (HP:0004481)	2.67196337
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.66005580
27	Abnormality of alanine metabolism (HP:0010916)	2.66005580
28	Hyperalaninemia (HP:0003348)	2.66005580
29	Decreased central vision (HP:0007663)	2.64164677
30	Abnormality of the renal cortex (HP:0011035)	2.63972256
31	Fibular hypoplasia (HP:0003038)	2.62937914
32	Medial flaring of the eyebrow (HP:0010747)	2.59179923
33	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.56349919
34	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.56349919
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.55777804
36	Tubular atrophy (HP:0000092)	2.54504261
37	Chronic hepatic failure (HP:0100626)	2.51736021
38	Abnormality of the renal medulla (HP:0100957)	2.50663878
39	Cystic liver disease (HP:0006706)	2.47104796
40	Decreased circulating renin level (HP:0003351)	2.46092790
41	Hyperventilation (HP:0002883)	2.44763737
42	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.42750369
43	Bilateral microphthalmos (HP:0007633)	2.40407631
44	Retinal dysplasia (HP:0007973)	2.40195777
45	Cerebellar dysplasia (HP:0007033)	2.38882085
46	Progressive inability to walk (HP:0002505)	2.35002803
47	Increased CSF lactate (HP:0002490)	2.34090423
48	Mitochondrial inheritance (HP:0001427)	2.33975808
49	Optic disc pallor (HP:0000543)	2.31052633
50	Pachygyria (HP:0001302)	2.23984708
51	Inability to walk (HP:0002540)	2.23383253
52	Partial agenesis of the corpus callosum (HP:0001338)	2.21069875
53	Abnormal drinking behavior (HP:0030082)	2.18629936
54	Polydipsia (HP:0001959)	2.18629936
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17296461
56	Cone-rod dystrophy (HP:0000548)	2.17042883
57	Pancreatic islet-cell hyperplasia (HP:0004510)	2.12884707
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10230316
59	Neoplasm of the adrenal cortex (HP:0100641)	2.07547324
60	Hyperglycinuria (HP:0003108)	2.06593334
61	Hyperglycinemia (HP:0002154)	2.06139951
62	Ketoacidosis (HP:0001993)	2.05760940
63	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.04941831
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.03559786
65	Narrow forehead (HP:0000341)	2.03217102
66	3-Methylglutaconic aciduria (HP:0003535)	2.01147621
67	Gait imbalance (HP:0002141)	1.99374538
68	Constricted visual fields (HP:0001133)	1.98048287
69	Renal cortical cysts (HP:0000803)	1.96429595
70	Optic nerve hypoplasia (HP:0000609)	1.93414829
71	Small hand (HP:0200055)	1.92879230
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.90279067
73	Absent/shortened dynein arms (HP:0200106)	1.90279067
74	Congenital primary aphakia (HP:0007707)	1.89674133
75	Aplasia/Hypoplasia of the macula (HP:0008059)	1.89100836
76	Increased serum lactate (HP:0002151)	1.85499493
77	Sclerocornea (HP:0000647)	1.84797027
78	Postaxial foot polydactyly (HP:0001830)	1.84134471
79	Congenital hepatic fibrosis (HP:0002612)	1.83665611
80	Volvulus (HP:0002580)	1.83052825
81	Severe visual impairment (HP:0001141)	1.82548954
82	Large for gestational age (HP:0001520)	1.82474346
83	Absent speech (HP:0001344)	1.82461933
84	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81606146
85	Abnormality of glycine metabolism (HP:0010895)	1.81606146
86	Ketosis (HP:0001946)	1.80475519
87	Male pseudohermaphroditism (HP:0000037)	1.76108056
88	Anencephaly (HP:0002323)	1.75998425
89	Colon cancer (HP:0003003)	1.75353389
90	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.75247086
91	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.75017555
92	Polyuria (HP:0000103)	1.74228278
93	Severe muscular hypotonia (HP:0006829)	1.73959409
94	Nephrogenic diabetes insipidus (HP:0009806)	1.73928544
95	Hepatic necrosis (HP:0002605)	1.73394739
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72798690
97	Furrowed tongue (HP:0000221)	1.70766314
98	Abnormal biliary tract physiology (HP:0012439)	1.70665641
99	Bile duct proliferation (HP:0001408)	1.70665641
100	Occipital encephalocele (HP:0002085)	1.70234273

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.31166527
2	ZAK	3.75241591
3	MAP3K9	3.53609923
4	INSRR	3.39454720
5	WNK3	2.64236566
6	MARK1	2.60617405
7	TLK1	2.55484635
8	TAF1	2.48115181
9	CASK	2.37897748
10	ADRBK2	2.35929074
11	GRK1	2.35392519
12	MAP4K2	2.21444461
13	NUAK1	2.04415922
14	BMPR1B	2.04007029
15	VRK2	1.72971296
16	MUSK	1.72096784
17	MAP3K4	1.62273704
18	WNK4	1.57783563
19	STK39	1.57740750
20	ACVR1B	1.52249648
21	EPHA4	1.51471757
22	MAPK13	1.50089088
23	OXSR1	1.49165404
24	BCKDK	1.34692359
25	PINK1	1.31320105
26	TRIM28	1.22029658
27	PAK3	1.21119697
28	DYRK2	1.17267065
29	MST4	1.10675488
30	PIK3CG	1.08909812
31	VRK1	1.05559179
32	MKNK2	1.05315379
33	DAPK2	1.03675972
34	BCR	1.03264511
35	CSNK1G3	1.02747034
36	CSNK1G1	0.99761544
37	PLK3	0.97016245
38	CSNK1G2	0.93567795
39	TIE1	0.93042206
40	TNIK	0.88678808
41	TAOK3	0.84067107
42	CHEK2	0.83916598
43	PRKCG	0.83884245
44	CSNK1A1L	0.82079710
45	RPS6KA4	0.80497546
46	MAP2K6	0.79584130
47	PRKG2	0.79018032
48	PRKCE	0.77229597
49	PDK2	0.76184880
50	PNCK	0.75883644
51	BUB1	0.74554070
52	PTK2B	0.74145268
53	ADRBK1	0.73232466
54	STK3	0.71219425
55	LIMK1	0.70857032
56	STK38L	0.69609368
57	FGFR2	0.67488582
58	MAPKAPK5	0.67163799
59	MKNK1	0.66806742
60	HIPK2	0.63987373
61	MAP2K7	0.63660671
62	TGFBR1	0.59534702
63	CAMKK2	0.59271288
64	NTRK2	0.59176045
65	CDC7	0.56207138
66	PHKG1	0.54430789
67	PHKG2	0.54430789
68	PLK2	0.53522931
69	STK11	0.50533886
70	TXK	0.47097789
71	IKBKB	0.47034411
72	NME1	0.46285004
73	PKN1	0.46228519
74	PRKAA2	0.43928189
75	CSNK1D	0.43701359
76	ATR	0.41799840
77	PLK1	0.40201980
78	PRKACA	0.40198077
79	RPS6KA5	0.39339820
80	CAMK2A	0.39303860
81	GRK5	0.39218613
82	PRKG1	0.38873093
83	SRPK1	0.38810189
84	ATM	0.38007793
85	WEE1	0.36916456
86	PRKAA1	0.35854391
87	AKT3	0.34445019
88	CAMK2D	0.33559999
89	TEC	0.33214611
90	STK16	0.33210429
91	ERBB3	0.33022144
92	CSNK1A1	0.32796090
93	PRKCA	0.32049629
94	BRSK2	0.31699848
95	NTRK3	0.30878547
96	CLK1	0.30621063
97	DAPK1	0.29802041
98	EIF2AK3	0.28810286
99	DYRK1A	0.28447792
100	SGK2	0.27965998

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.58114227
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.56385954
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.42226264
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.42157453
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41582255
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.37321156
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.25452290
8	Butanoate metabolism_Homo sapiens_hsa00650	2.24199830
9	Phototransduction_Homo sapiens_hsa04744	2.23228839
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22150622
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.20137207
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.05916243
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90355046
14	Nicotine addiction_Homo sapiens_hsa05033	1.89489104
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.87872303
16	Parkinsons disease_Homo sapiens_hsa05012	1.85208595
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78067137
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.77097791
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77093197
20	One carbon pool by folate_Homo sapiens_hsa00670	1.75350115
21	Propanoate metabolism_Homo sapiens_hsa00640	1.74333938
22	RNA polymerase_Homo sapiens_hsa03020	1.64371754
23	Taste transduction_Homo sapiens_hsa04742	1.59063544
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57793075
25	Basal transcription factors_Homo sapiens_hsa03022	1.56678741
26	Homologous recombination_Homo sapiens_hsa03440	1.52768317
27	Huntingtons disease_Homo sapiens_hsa05016	1.50638584
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.46856433
29	RNA degradation_Homo sapiens_hsa03018	1.43958762
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43550486
31	Sulfur relay system_Homo sapiens_hsa04122	1.40426749
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39287698
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31737891
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26114916
35	Olfactory transduction_Homo sapiens_hsa04740	1.25929427
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.21756907
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19815032
38	Morphine addiction_Homo sapiens_hsa05032	1.17539731
39	Caffeine metabolism_Homo sapiens_hsa00232	1.15686541
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.15325872
41	Glycerolipid metabolism_Homo sapiens_hsa00561	1.12586045
42	Alzheimers disease_Homo sapiens_hsa05010	1.11668869
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.08154141
44	Sphingolipid metabolism_Homo sapiens_hsa00600	1.07631332
45	GABAergic synapse_Homo sapiens_hsa04727	1.07498082
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06734151
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.03022947
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99950778
49	Circadian entrainment_Homo sapiens_hsa04713	0.99771678
50	Insulin secretion_Homo sapiens_hsa04911	0.96163460
51	Proteasome_Homo sapiens_hsa03050	0.95714495
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88290223
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88054885
54	Retinol metabolism_Homo sapiens_hsa00830	0.87869431
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87524010
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85485479
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85259311
58	Peroxisome_Homo sapiens_hsa04146	0.84949068
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84851351
60	Serotonergic synapse_Homo sapiens_hsa04726	0.83628582
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83023080
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82228783
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80933844
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.79194712
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75703937
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75133912
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73288143
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72127887
69	Metabolic pathways_Homo sapiens_hsa01100	0.70880662
70	Fatty acid degradation_Homo sapiens_hsa00071	0.69700015
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.68645818
72	Ribosome_Homo sapiens_hsa03010	0.67987959
73	ABC transporters_Homo sapiens_hsa02010	0.67717766
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66717790
75	Purine metabolism_Homo sapiens_hsa00230	0.65457777
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65346266
77	Sulfur metabolism_Homo sapiens_hsa00920	0.62490277
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60510396
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.57452007
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.57294533
81	Mineral absorption_Homo sapiens_hsa04978	0.57172370
82	Salivary secretion_Homo sapiens_hsa04970	0.55800394
83	Histidine metabolism_Homo sapiens_hsa00340	0.54793202
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54471546
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.53027608
86	Fatty acid elongation_Homo sapiens_hsa00062	0.52538613
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.52304020
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.51937771
89	Glutathione metabolism_Homo sapiens_hsa00480	0.50634646
90	RNA transport_Homo sapiens_hsa03013	0.46893282
91	Regulation of autophagy_Homo sapiens_hsa04140	0.45136842
92	p53 signaling pathway_Homo sapiens_hsa04115	0.44917206
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.43732657
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.41712557
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39499898
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37960630
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37700374
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36294330
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33545931
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.33111033

DUXAP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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