DUXAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.67292737
2regulation of translational fidelity (GO:0006450)5.15723169
3nuclear pore organization (GO:0006999)4.93726806
4ribosome assembly (GO:0042255)4.85409471
5Golgi transport vesicle coating (GO:0048200)4.76175776
6COPI coating of Golgi vesicle (GO:0048205)4.76175776
7nucleobase-containing small molecule interconversion (GO:0015949)4.55797153
8pore complex assembly (GO:0046931)4.45252964
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.25695877
10positive regulation of catecholamine secretion (GO:0033605)4.22518351
11protein retention in ER lumen (GO:0006621)4.21617533
12proline biosynthetic process (GO:0006561)3.81180804
13mitotic chromosome condensation (GO:0007076)3.78371928
14cellular response to interferon-alpha (GO:0035457)3.62746407
15mRNA cleavage (GO:0006379)3.57444986
16COPII vesicle coating (GO:0048208)3.49823354
17mitochondrial DNA replication (GO:0006264)3.49359889
18binding of sperm to zona pellucida (GO:0007339)3.32371855
19vagina development (GO:0060068)3.30712404
20DNA unwinding involved in DNA replication (GO:0006268)3.25551405
21negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.24222294
22mitochondrial DNA metabolic process (GO:0032042)3.19836339
23AMP metabolic process (GO:0046033)3.16530808
24regulation of translational elongation (GO:0006448)3.14745101
25desmosome organization (GO:0002934)3.10272627
26iron ion import (GO:0097286)3.04000065
27nucleotide-sugar biosynthetic process (GO:0009226)3.02344792
28regulation of hydrogen peroxide-induced cell death (GO:1903205)2.98467193
29mitotic sister chromatid segregation (GO:0000070)2.96934915
30regulation of oxidative stress-induced neuron death (GO:1903203)2.96746149
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96434656
32formation of translation preinitiation complex (GO:0001731)2.94218884
33regulation of sister chromatid cohesion (GO:0007063)2.92382196
34negative regulation of response to reactive oxygen species (GO:1901032)2.91492394
35cellular zinc ion homeostasis (GO:0006882)2.91029347
36TOR signaling (GO:0031929)2.84945762
37rRNA transcription (GO:0009303)2.84321550
38tRNA aminoacylation for protein translation (GO:0006418)2.79795347
39protein localization to chromosome, centromeric region (GO:0071459)2.77596190
40folic acid-containing compound biosynthetic process (GO:0009396)2.75164430
41protein maturation by protein folding (GO:0022417)2.75136093
42sister chromatid segregation (GO:0000819)2.74859806
43mitotic nuclear envelope disassembly (GO:0007077)2.73629189
44protein complex localization (GO:0031503)2.72970620
45amino acid activation (GO:0043038)2.71391075
46tRNA aminoacylation (GO:0043039)2.71391075
47response to muscle activity (GO:0014850)2.68199196
48zinc ion transmembrane transport (GO:0071577)2.66740868
49protein localization to cell surface (GO:0034394)2.63940346
50mitotic metaphase plate congression (GO:0007080)2.61330669
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61175514
52ribosome biogenesis (GO:0042254)2.59759565
53regulation of centrosome cycle (GO:0046605)2.59665390
54regulation of mitotic spindle organization (GO:0060236)2.57324470
55positive regulation of DNA-dependent DNA replication (GO:2000105)2.55834286
56DNA strand elongation (GO:0022616)2.55496393
57DNA strand elongation involved in DNA replication (GO:0006271)2.55252191
58regulation of keratinocyte differentiation (GO:0045616)2.55001395
59DNA duplex unwinding (GO:0032508)2.53829550
60protein N-linked glycosylation via asparagine (GO:0018279)2.53792367
61chromosome condensation (GO:0030261)2.53541144
62DNA replication initiation (GO:0006270)2.51680917
63proline metabolic process (GO:0006560)2.51508551
64pteridine-containing compound biosynthetic process (GO:0042559)2.51394819
65peptidyl-asparagine modification (GO:0018196)2.51227003
66vesicle coating (GO:0006901)2.47951435
67DNA topological change (GO:0006265)2.46158033
68nuclear envelope disassembly (GO:0051081)2.45978402
69membrane disassembly (GO:0030397)2.45978402
70apoptotic cell clearance (GO:0043277)2.45843285
71folic acid metabolic process (GO:0046655)2.45714339
72regulation of centrosome duplication (GO:0010824)2.45622253
73protein N-linked glycosylation (GO:0006487)2.45510849
74UDP-N-acetylglucosamine metabolic process (GO:0006047)2.44024745
75protein localization to kinetochore (GO:0034501)2.43647100
76activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42109069
77peptidyl-proline hydroxylation (GO:0019511)2.40906975
78female genitalia development (GO:0030540)2.39968839
79branching involved in mammary gland duct morphogenesis (GO:0060444)2.39167409
80telomere maintenance via semi-conservative replication (GO:0032201)2.38769888
81DNA geometric change (GO:0032392)2.38410809
82nucleoside diphosphate biosynthetic process (GO:0009133)2.38021499
83positive regulation of nuclease activity (GO:0032075)2.37856264
84rRNA modification (GO:0000154)2.36892752
85regulation of gonadotropin secretion (GO:0032276)2.36182224
86ribonucleoprotein complex biogenesis (GO:0022613)2.35833222
87glutamine family amino acid biosynthetic process (GO:0009084)2.35428759
88tRNA methylation (GO:0030488)2.34611171
89rRNA methylation (GO:0031167)2.34051073
90protein export from nucleus (GO:0006611)2.33180563
91mitotic sister chromatid cohesion (GO:0007064)2.32091532
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.30345832
93L-phenylalanine metabolic process (GO:0006558)2.30345832
94hepatocyte differentiation (GO:0070365)2.30307527
95establishment of integrated proviral latency (GO:0075713)2.29785953
96ribosomal small subunit biogenesis (GO:0042274)2.29419978
97protein localization to endosome (GO:0036010)2.28029058
98endoplasmic reticulum unfolded protein response (GO:0030968)2.27876566
99hepatocyte apoptotic process (GO:0097284)2.27717863
100negative regulation of cell size (GO:0045792)2.27539886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44241206
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.60894972
3ZNF263_19887448_ChIP-Seq_K562_Human4.05956884
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.85914232
5AR_21909140_ChIP-Seq_LNCAP_Human3.67322953
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.50815328
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03035742
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94950834
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92307333
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.65906636
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.51157471
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40332699
13DCP1A_22483619_ChIP-Seq_HELA_Human2.36235843
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32773873
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32630200
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.27454728
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.19745147
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16946092
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.16077120
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15689418
21ZFX_18555785_ChIP-Seq_MESCs_Mouse2.13914163
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11009191
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08999665
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.00889017
25CLOCK_20551151_ChIP-Seq_293T_Human1.98789468
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98505546
27XRN2_22483619_ChIP-Seq_HELA_Human1.93349154
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92765857
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92382122
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.87882841
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84207959
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.77973588
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.77925705
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74969598
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71801855
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69495572
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69132322
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68948060
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65822672
40GABP_19822575_ChIP-Seq_HepG2_Human1.62516387
41KDM5A_27292631_Chip-Seq_BREAST_Human1.58839272
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55440410
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.54236495
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54050914
45ATF3_27146783_Chip-Seq_COLON_Human1.52097865
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.50884438
47CHD1_26751641_Chip-Seq_LNCaP_Human1.49610808
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47416392
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44373498
50TFEB_21752829_ChIP-Seq_HELA_Human1.43926497
51SOX17_20123909_ChIP-Seq_XEN_Mouse1.40364050
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39240897
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38858611
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38501131
55TTF2_22483619_ChIP-Seq_HELA_Human1.37610097
56ELK1_19687146_ChIP-ChIP_HELA_Human1.36762987
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33706598
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30764205
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30464310
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30193756
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29527050
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28890357
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28890357
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28209775
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26906633
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26713621
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23823593
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22380772
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20563522
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20284752
71RACK7_27058665_Chip-Seq_MCF-7_Human1.17947696
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17736903
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17554455
74TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17503223
75ELF5_23300383_ChIP-Seq_T47D_Human1.16935015
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.16242724
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15387841
78GATA6_25053715_ChIP-Seq_YYC3_Human1.13730638
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09485203
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08763533
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07738704
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07372580
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06405788
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.05854745
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05666544
86FOXP3_21729870_ChIP-Seq_TREG_Human1.04965547
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04907479
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04641284
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04196167
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02377830
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01891424
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01527827
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01437652
94UBF1/2_26484160_Chip-Seq_HMECs_Human0.99760606
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99562827
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96563749
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96343734
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94437063
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94282582
100BRD4_25478319_ChIP-Seq_HGPS_Human0.93683370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.77231925
2MP0002877_abnormal_melanocyte_morpholog2.58476380
3MP0009697_abnormal_copulation2.48966096
4MP0010094_abnormal_chromosome_stability2.47115904
5MP0003315_abnormal_perineum_morphology2.41534203
6MP0005408_hypopigmentation2.40051949
7MP0004272_abnormal_basement_membrane2.32705972
8MP0003111_abnormal_nucleus_morphology2.31676484
9MP0010234_abnormal_vibrissa_follicle2.28714976
10MP0004957_abnormal_blastocyst_morpholog2.27641398
11MP0004233_abnormal_muscle_weight2.26835261
12MP0003693_abnormal_embryo_hatching2.19075922
13MP0001661_extended_life_span2.09871055
14MP0005058_abnormal_lysosome_morphology2.09187238
15MP0009780_abnormal_chondrocyte_physiolo2.08566151
16MP0004782_abnormal_surfactant_physiolog2.02973057
17MP0002160_abnormal_reproductive_system1.96760397
18MP0003077_abnormal_cell_cycle1.91474602
19MP0000537_abnormal_urethra_morphology1.90690495
20MP0008932_abnormal_embryonic_tissue1.79888026
21MP0004264_abnormal_extraembryonic_tissu1.73216269
22MP0005451_abnormal_body_composition1.72592537
23MP0003705_abnormal_hypodermis_morpholog1.69039533
24MP0003950_abnormal_plasma_membrane1.68318763
25MP0008007_abnormal_cellular_replicative1.67834342
26MP0005623_abnormal_meninges_morphology1.59622117
27MP0004084_abnormal_cardiac_muscle1.58704351
28MP0005409_darkened_coat_color1.58654067
29MP0003718_maternal_effect1.52275120
30MP0005360_urolithiasis1.49824125
31MP0005410_abnormal_fertilization1.46437699
32MP0003566_abnormal_cell_adhesion1.43873245
33MP0000013_abnormal_adipose_tissue1.41378347
34MP0005257_abnormal_intraocular_pressure1.40217996
35MP0005330_cardiomyopathy1.34417113
36MP0001730_embryonic_growth_arrest1.32924910
37MP0010352_gastrointestinal_tract_polyps1.32552989
38MP0005187_abnormal_penis_morphology1.32056776
39MP0000003_abnormal_adipose_tissue1.29557353
40MP0000627_abnormal_mammary_gland1.28750826
41MP0008058_abnormal_DNA_repair1.28395149
42MP0005076_abnormal_cell_differentiation1.27320973
43MP0001849_ear_inflammation1.26768446
44MP0002269_muscular_atrophy1.25949341
45MP0000762_abnormal_tongue_morphology1.25635607
46MP0000350_abnormal_cell_proliferation1.23249012
47MP0008004_abnormal_stomach_pH1.22245965
48MP0010368_abnormal_lymphatic_system1.19794323
49MP0001881_abnormal_mammary_gland1.17374484
50MP0003984_embryonic_growth_retardation1.16881209
51MP0001697_abnormal_embryo_size1.16820917
52MP0001672_abnormal_embryogenesis/_devel1.16746904
53MP0005380_embryogenesis_phenotype1.16746904
54MP0002080_prenatal_lethality1.15008128
55MP0002088_abnormal_embryonic_growth/wei1.14293400
56MP0004808_abnormal_hematopoietic_stem1.13320644
57MP0002086_abnormal_extraembryonic_tissu1.12954136
58MP0003385_abnormal_body_wall1.12416410
59MP0000749_muscle_degeneration1.11371688
60MP0008057_abnormal_DNA_replication1.10371235
61MP0001915_intracranial_hemorrhage1.09163400
62MP0005389_reproductive_system_phenotype1.07585950
63MP0010307_abnormal_tumor_latency1.02002346
64MP0003941_abnormal_skin_development1.00809394
65MP0002060_abnormal_skin_morphology1.00670533
66MP0004185_abnormal_adipocyte_glucose0.98028490
67MP0003868_abnormal_feces_composition0.97555664
68MP0006036_abnormal_mitochondrial_physio0.96434496
69MP0002090_abnormal_vision0.93368987
70MP0002084_abnormal_developmental_patter0.92062054
71MP0002132_abnormal_respiratory_system0.88510236
72MP0001545_abnormal_hematopoietic_system0.87970599
73MP0005397_hematopoietic_system_phenotyp0.87970599
74MP0005621_abnormal_cell_physiology0.86110222
75MP0002796_impaired_skin_barrier0.85482603
76MP0008260_abnormal_autophagy0.83552999
77MP0005501_abnormal_skin_physiology0.83502772
78MP0000681_abnormal_thyroid_gland0.83084046
79MP0003115_abnormal_respiratory_system0.82943277
80MP0008438_abnormal_cutaneous_collagen0.82313280
81MP0002085_abnormal_embryonic_tissue0.82293102
82MP0001919_abnormal_reproductive_system0.82078526
83MP0008775_abnormal_heart_ventricle0.82059313
84MP0004197_abnormal_fetal_growth/weight/0.80198029
85MP0003123_paternal_imprinting0.79087285
86MP0003936_abnormal_reproductive_system0.78065083
87MP0001727_abnormal_embryo_implantation0.78036554
88MP0002009_preneoplasia0.77444660
89MP0001216_abnormal_epidermal_layer0.77400509
90MP0000358_abnormal_cell_content/0.76831427
91MP0000747_muscle_weakness0.74329244
92MP0000313_abnormal_cell_death0.73561132
93MP0003786_premature_aging0.73049585
94MP0002092_abnormal_eye_morphology0.72817289
95MP0005384_cellular_phenotype0.72701804
96MP0003943_abnormal_hepatobiliary_system0.71376060
97MP0003942_abnormal_urinary_system0.70412528
98MP0005197_abnormal_uvea_morphology0.70183359
99MP0001340_abnormal_eyelid_morphology0.69713270
100MP0006138_congestive_heart_failure0.69572228

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.19901359
2Asymmetry of the thorax (HP:0001555)4.07781734
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68531752
4Reduced antithrombin III activity (HP:0001976)3.60670639
5Abnormality of the intrinsic pathway (HP:0010989)3.57977882
6Progressive external ophthalmoplegia (HP:0000590)3.25003869
7Short nail (HP:0001799)2.97398826
8Deep venous thrombosis (HP:0002625)2.95763864
9Prolonged partial thromboplastin time (HP:0003645)2.74643129
10Self-mutilation (HP:0000742)2.67099305
11Cutaneous melanoma (HP:0012056)2.65614224
12Right ventricular cardiomyopathy (HP:0011663)2.63432730
13Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.61082659
14Abnormality of the preputium (HP:0100587)2.55100277
15Small epiphyses (HP:0010585)2.54559663
16Deviation of the thumb (HP:0009603)2.53563272
17Microglossia (HP:0000171)2.45680605
18Abnormality of the common coagulation pathway (HP:0010990)2.44388738
19Progressive muscle weakness (HP:0003323)2.39487068
20Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38009323
21Proximal placement of thumb (HP:0009623)2.35925868
22Abnormality of carpal bone ossification (HP:0006257)2.35809331
23Aplasia cutis congenita (HP:0001057)2.34881520
24Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.34860255
25Insidious onset (HP:0003587)2.33278080
26Termporal pattern (HP:0011008)2.33278080
27Resting tremor (HP:0002322)2.25695439
28Premature rupture of membranes (HP:0001788)2.19792690
29Entropion (HP:0000621)2.17522058
30Spinal rigidity (HP:0003306)2.17228286
31Renal duplication (HP:0000075)2.15830542
32Osteolytic defects of the hand bones (HP:0009699)2.09454858
33Osteolytic defects of the phalanges of the hand (HP:0009771)2.09454858
34Abnormality of the distal phalanges of the toes (HP:0010182)2.09362615
35Syringomyelia (HP:0003396)2.09138400
36Spinal cord lesions (HP:0100561)2.09138400
37Capillary hemangiomas (HP:0005306)2.05850545
38Sensory axonal neuropathy (HP:0003390)2.01656051
39Flat acetabular roof (HP:0003180)2.01553783
40Orthostatic hypotension (HP:0001278)2.00735729
41Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.99464577
42Ankyloglossia (HP:0010296)1.99350010
43Ragged-red muscle fibers (HP:0003200)1.98795395
44Meckel diverticulum (HP:0002245)1.97845978
45Abnormality of the ileum (HP:0001549)1.96141624
46Aplasia/Hypoplasia of the uvula (HP:0010293)1.95389946
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95374592
48Abnormality of the carotid arteries (HP:0005344)1.94487943
49Elbow flexion contracture (HP:0002987)1.93404236
50Missing ribs (HP:0000921)1.93096622
51Abnormality of chromosome stability (HP:0003220)1.91540107
52Cerebellar dysplasia (HP:0007033)1.91237608
53Squamous cell carcinoma (HP:0002860)1.90616771
54Flattened epiphyses (HP:0003071)1.90134866
55Cholecystitis (HP:0001082)1.88752001
56Abnormal gallbladder physiology (HP:0012438)1.88752001
57Ureteral duplication (HP:0000073)1.87879200
58Ulnar bowing (HP:0003031)1.87680395
59Wide cranial sutures (HP:0010537)1.86734704
60Abnormality of the columella (HP:0009929)1.85869935
61Hyporeflexia of lower limbs (HP:0002600)1.83864621
62Hypokinesia (HP:0002375)1.83642821
63Facial hemangioma (HP:0000329)1.83516356
64Myelodysplasia (HP:0002863)1.83341916
65Abnormalities of placenta or umbilical cord (HP:0001194)1.83289775
66Insomnia (HP:0100785)1.82971023
67Secondary amenorrhea (HP:0000869)1.82314045
68Abnormal ossification of hand bones (HP:0005921)1.80810459
69Glucose intolerance (HP:0000833)1.78899805
70Abnormal foot bone ossification (HP:0010675)1.78851148
71Generalized amyotrophy (HP:0003700)1.77642139
72Abnormal tarsal ossification (HP:0008369)1.77523787
73Rhizomelia (HP:0008905)1.76453470
74Melanoma (HP:0002861)1.76417308
75Abnormality of methionine metabolism (HP:0010901)1.76115367
76Abnormality of the umbilical cord (HP:0010881)1.74807759
77Abnormality of glycolysis (HP:0004366)1.74038548
78Septate vagina (HP:0001153)1.73520078
79Mitral stenosis (HP:0001718)1.72088998
80Proximal tubulopathy (HP:0000114)1.70969720
81Arterial tortuosity (HP:0005116)1.69837757
82Back pain (HP:0003418)1.69375547
83Scapular winging (HP:0003691)1.67267682
84Abnormality of the acetabulum (HP:0003170)1.66930644
85Freckling (HP:0001480)1.65919628
86Hyperacusis (HP:0010780)1.65594875
87Gonadal dysgenesis (HP:0000133)1.64994716
88Poikiloderma (HP:0001029)1.64684904
89Hypercholesterolemia (HP:0003124)1.64474787
90Abnormal protein glycosylation (HP:0012346)1.64087766
91Abnormal glycosylation (HP:0012345)1.64087766
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64087766
93Abnormal protein N-linked glycosylation (HP:0012347)1.64087766
94Long toe (HP:0010511)1.63655444
95Protrusio acetabuli (HP:0003179)1.62759020
96Hypoplasia of the uterus (HP:0000013)1.62552626
97Aplastic anemia (HP:0001915)1.62422421
98Vertebral compression fractures (HP:0002953)1.62335490
99Menorrhagia (HP:0000132)1.60783073
100Increased nuchal translucency (HP:0010880)1.59958293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.67524724
2SCYL23.53608341
3PBK3.49220228
4EIF2AK13.27947580
5MST1R3.18541414
6PINK12.86975039
7LATS12.64697909
8EIF2AK32.48766661
9IRAK32.47117546
10NEK12.43991173
11EEF2K2.37304224
12TRIB32.05097339
13ICK2.02388100
14LATS22.02215287
15NEK21.93340585
16MET1.92165901
17EPHA21.83230334
18MAP3K121.79232454
19WEE11.66322972
20MARK31.61867970
21TSSK61.59350528
22CDK81.44070407
23TESK11.43422408
24RPS6KB21.41285723
25TRIM281.40136903
26SRPK11.38188348
27ARAF1.37628901
28CDK121.37518214
29BUB11.30164033
30MYLK1.28452391
31LIMK11.26290705
32TTK1.24629775
33ILK1.24507099
34PAK41.24244562
35PDGFRA1.21871964
36ZAK1.15059900
37ERBB41.04331978
38PKN20.99755044
39TRPM70.96769037
40AURKB0.96030330
41CCNB10.95881498
42CDK70.94779735
43RAF10.94514071
44PAK20.94370115
45STK380.93845093
46MAPKAPK30.91168471
47MAP2K30.85135316
48STK38L0.82873513
49PTK20.80059116
50KSR20.79688084
51MTOR0.78349227
52CHEK20.76438439
53STK30.76017302
54PLK10.73818859
55MAP3K100.71645321
56IRAK20.69815720
57MELK0.66470346
58PLK30.65463736
59RPS6KB10.63470171
60CLK10.63177604
61BRAF0.63122521
62ERBB30.62325952
63AKT20.61080396
64PIK3CA0.59019572
65FGFR40.58980782
66BRSK10.57973047
67BCR0.56529071
68KSR10.56314839
69MOS0.55432033
70VRK20.54690863
71ATR0.53727529
72CDC70.53053949
73CSNK1A1L0.52752939
74ATM0.52687972
75AURKA0.50814992
76MAPK110.50575279
77MAP3K80.49857011
78SMG10.49247481
79SIK10.48575230
80NEK60.48451575
81DAPK30.47994682
82CHEK10.47552712
83TLK10.46553370
84EIF2AK20.46253647
85PIM20.46175863
86MAP3K20.46137739
87ERN10.43844991
88PRKCI0.43289866
89MAP3K90.42609217
90RPS6KA40.39891232
91RET0.39870299
92NEK90.39415327
93MAP2K10.38925194
94PAK10.38849756
95SIK30.38304754
96DAPK10.37956494
97MAP3K10.37784150
98CDK40.36031982
99CDK10.33300114
100PAK60.32935958

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.32828154
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83519615
3DNA replication_Homo sapiens_hsa030302.60198250
4Folate biosynthesis_Homo sapiens_hsa007902.38183264
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.31825549
6N-Glycan biosynthesis_Homo sapiens_hsa005102.25879263
7Proteasome_Homo sapiens_hsa030502.07189613
8Biosynthesis of amino acids_Homo sapiens_hsa012301.92712212
9RNA transport_Homo sapiens_hsa030131.92331569
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86023288
11Nucleotide excision repair_Homo sapiens_hsa034201.85583981
12Pentose phosphate pathway_Homo sapiens_hsa000301.85560111
13Non-homologous end-joining_Homo sapiens_hsa034501.72724103
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.70340327
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65309692
16Pyrimidine metabolism_Homo sapiens_hsa002401.63996965
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.59835499
18Cell cycle_Homo sapiens_hsa041101.57836396
19Sulfur relay system_Homo sapiens_hsa041221.56383953
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55821710
21Mismatch repair_Homo sapiens_hsa034301.54411602
22Pyruvate metabolism_Homo sapiens_hsa006201.47610485
23Fructose and mannose metabolism_Homo sapiens_hsa000511.41450003
24One carbon pool by folate_Homo sapiens_hsa006701.38894924
25Glutathione metabolism_Homo sapiens_hsa004801.38197806
26Carbon metabolism_Homo sapiens_hsa012001.37699626
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31614162
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29762423
29Selenocompound metabolism_Homo sapiens_hsa004501.26725753
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.24798875
31Arginine biosynthesis_Homo sapiens_hsa002201.23281420
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.22888897
33Fatty acid biosynthesis_Homo sapiens_hsa000611.22066265
34Vitamin B6 metabolism_Homo sapiens_hsa007501.21851263
35Spliceosome_Homo sapiens_hsa030401.20090052
36Thyroid cancer_Homo sapiens_hsa052161.17978325
37Phenylalanine metabolism_Homo sapiens_hsa003601.16505139
38Basal transcription factors_Homo sapiens_hsa030221.10879926
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10807482
40RNA polymerase_Homo sapiens_hsa030201.10531412
41mRNA surveillance pathway_Homo sapiens_hsa030151.07194172
42Fanconi anemia pathway_Homo sapiens_hsa034601.06228931
43Base excision repair_Homo sapiens_hsa034101.05279049
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05233911
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97421709
46Purine metabolism_Homo sapiens_hsa002300.97308948
47Galactose metabolism_Homo sapiens_hsa000520.95478879
48Small cell lung cancer_Homo sapiens_hsa052220.94069909
49Non-small cell lung cancer_Homo sapiens_hsa052230.94069251
50Fatty acid metabolism_Homo sapiens_hsa012120.93401208
51Tyrosine metabolism_Homo sapiens_hsa003500.92407348
52Bladder cancer_Homo sapiens_hsa052190.85542579
53p53 signaling pathway_Homo sapiens_hsa041150.85006876
54Complement and coagulation cascades_Homo sapiens_hsa046100.84544751
55Fatty acid elongation_Homo sapiens_hsa000620.84306418
56Other glycan degradation_Homo sapiens_hsa005110.83976615
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79043071
58Proteoglycans in cancer_Homo sapiens_hsa052050.76174169
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76143418
60Apoptosis_Homo sapiens_hsa042100.74927813
61Chronic myeloid leukemia_Homo sapiens_hsa052200.73966788
62Oocyte meiosis_Homo sapiens_hsa041140.73259233
63Ribosome_Homo sapiens_hsa030100.72706627
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72637868
65Vibrio cholerae infection_Homo sapiens_hsa051100.66568379
66Alcoholism_Homo sapiens_hsa050340.66157721
67Sulfur metabolism_Homo sapiens_hsa009200.66016388
68Systemic lupus erythematosus_Homo sapiens_hsa053220.65973015
69Homologous recombination_Homo sapiens_hsa034400.65704074
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63562687
71Hippo signaling pathway_Homo sapiens_hsa043900.63112626
72mTOR signaling pathway_Homo sapiens_hsa041500.62727204
73TGF-beta signaling pathway_Homo sapiens_hsa043500.62346355
74Sphingolipid metabolism_Homo sapiens_hsa006000.62111052
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61248046
76Arginine and proline metabolism_Homo sapiens_hsa003300.59632766
77Gap junction_Homo sapiens_hsa045400.59101121
78Endometrial cancer_Homo sapiens_hsa052130.58591000
79RNA degradation_Homo sapiens_hsa030180.58426733
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58355752
81Viral carcinogenesis_Homo sapiens_hsa052030.58106224
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57503759
83Pancreatic cancer_Homo sapiens_hsa052120.54355722
84Glioma_Homo sapiens_hsa052140.53492444
85Prostate cancer_Homo sapiens_hsa052150.50748719
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50080517
87Melanoma_Homo sapiens_hsa052180.49971230
88Focal adhesion_Homo sapiens_hsa045100.49831426
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49600547
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49111971
91Propanoate metabolism_Homo sapiens_hsa006400.48156478
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45896553
93ECM-receptor interaction_Homo sapiens_hsa045120.45527768
94MicroRNAs in cancer_Homo sapiens_hsa052060.45242939
95Metabolic pathways_Homo sapiens_hsa011000.43959996
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.43928404
97Adherens junction_Homo sapiens_hsa045200.43404796
98AMPK signaling pathway_Homo sapiens_hsa041520.43121456
99Insulin signaling pathway_Homo sapiens_hsa049100.41543917
100Lysine degradation_Homo sapiens_hsa003100.36742300

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