ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	5.54916981
2	nuclear pore organization (GO:0006999)	5.04834251
3	regulation of translational fidelity (GO:0006450)	4.34043852
4	pore complex assembly (GO:0046931)	4.14845970
5	COPI coating of Golgi vesicle (GO:0048205)	3.93989218
6	Golgi transport vesicle coating (GO:0048200)	3.93989218
7	ribosome assembly (GO:0042255)	3.89327083
8	proline biosynthetic process (GO:0006561)	3.83788946
9	COPII vesicle coating (GO:0048208)	3.47324777
10	mRNA cleavage (GO:0006379)	3.42702889
11	mitotic chromosome condensation (GO:0007076)	3.40471393
12	regulation of centriole replication (GO:0046599)	3.36662768
13	DNA replication initiation (GO:0006270)	3.33586733
14	regulation of hippo signaling (GO:0035330)	3.33035244
15	regulation of centrosome duplication (GO:0010824)	3.31292682
16	regulation of centrosome cycle (GO:0046605)	3.27750619
17	mitotic sister chromatid cohesion (GO:0007064)	3.21609764
18	mitotic sister chromatid segregation (GO:0000070)	3.16251923
19	DNA duplex unwinding (GO:0032508)	3.15206560
20	sister chromatid segregation (GO:0000819)	3.10321412
21	tRNA aminoacylation for protein translation (GO:0006418)	3.09926816
22	DNA unwinding involved in DNA replication (GO:0006268)	3.09670747
23	DNA strand elongation involved in DNA replication (GO:0006271)	3.09499668
24	DNA strand elongation (GO:0022616)	3.09053868
25	DNA geometric change (GO:0032392)	3.06093420
26	mitotic nuclear envelope disassembly (GO:0007077)	3.04395036
27	tRNA aminoacylation (GO:0043039)	3.03629307
28	amino acid activation (GO:0043038)	3.03629307
29	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.01714821
30	folic acid-containing compound biosynthetic process (GO:0009396)	2.94657894
31	nucleobase-containing small molecule interconversion (GO:0015949)	2.91246698
32	iron ion import (GO:0097286)	2.89404746
33	mitochondrial DNA replication (GO:0006264)	2.81474423
34	regulation of translational elongation (GO:0006448)	2.79623436
35	ribosome biogenesis (GO:0042254)	2.79154802
36	mitochondrial DNA metabolic process (GO:0032042)	2.78813587
37	telomere maintenance via semi-conservative replication (GO:0032201)	2.74813420
38	nucleotide-sugar biosynthetic process (GO:0009226)	2.73952502
39	nuclear envelope disassembly (GO:0051081)	2.72756422
40	membrane disassembly (GO:0030397)	2.72756422
41	regulation of mitotic spindle organization (GO:0060236)	2.71993282
42	DNA replication checkpoint (GO:0000076)	2.69968098
43	binding of sperm to zona pellucida (GO:0007339)	2.68592913
44	viral mRNA export from host cell nucleus (GO:0046784)	2.68492543
45	proline metabolic process (GO:0006560)	2.66427006
46	DNA conformation change (GO:0071103)	2.63689015
47	biotin metabolic process (GO:0006768)	2.62111129
48	formation of translation preinitiation complex (GO:0001731)	2.61347970
49	TOR signaling (GO:0031929)	2.60621461
50	rRNA transcription (GO:0009303)	2.56886124
51	very-low-density lipoprotein particle assembly (GO:0034379)	2.56412854
52	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.55037031
53	L-phenylalanine metabolic process (GO:0006558)	2.55037031
54	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.52972675
55	regulation of sister chromatid cohesion (GO:0007063)	2.51724719
56	peptidyl-lysine dimethylation (GO:0018027)	2.51646958
57	chromosome condensation (GO:0030261)	2.46650192
58	regulation of RNA export from nucleus (GO:0046831)	2.45821919
59	protein retention in ER lumen (GO:0006621)	2.44967857
60	protein N-linked glycosylation via asparagine (GO:0018279)	2.44184270
61	tetrahydrofolate metabolic process (GO:0046653)	2.43761877
62	peptidyl-asparagine modification (GO:0018196)	2.43490249
63	telomere maintenance via recombination (GO:0000722)	2.42846205
64	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.42355333
65	cellular zinc ion homeostasis (GO:0006882)	2.42116290
66	folic acid-containing compound metabolic process (GO:0006760)	2.41646997
67	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.39862280
68	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.38238303
69	non-recombinational repair (GO:0000726)	2.37810949
70	double-strand break repair via nonhomologous end joining (GO:0006303)	2.37810949
71	zinc ion transmembrane transport (GO:0071577)	2.37487062
72	maturation of 5.8S rRNA (GO:0000460)	2.36096595
73	DNA replication-dependent nucleosome assembly (GO:0006335)	2.35498626
74	DNA replication-dependent nucleosome organization (GO:0034723)	2.35498626
75	positive regulation of nuclease activity (GO:0032075)	2.34811649
76	positive regulation of cell size (GO:0045793)	2.34642150
77	protein N-linked glycosylation (GO:0006487)	2.33574617
78	DNA packaging (GO:0006323)	2.33042154
79	positive regulation of cell cycle checkpoint (GO:1901978)	2.30770605
80	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.30099118
81	mitotic recombination (GO:0006312)	2.29768544
82	glutamine family amino acid biosynthetic process (GO:0009084)	2.28664615
83	regulation of DNA damage checkpoint (GO:2000001)	2.27947686
84	snRNA processing (GO:0016180)	2.27111642
85	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.26646795
86	pteridine-containing compound biosynthetic process (GO:0042559)	2.26128694
87	termination of RNA polymerase I transcription (GO:0006363)	2.25519486
88	snRNA metabolic process (GO:0016073)	2.25175978
89	tRNA methylation (GO:0030488)	2.24297844
90	regulation of spindle organization (GO:0090224)	2.23238839
91	regulation of mitochondrial translation (GO:0070129)	2.23076036
92	aspartate family amino acid biosynthetic process (GO:0009067)	2.22954218
93	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.22341032
94	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.21850542
95	nuclear envelope organization (GO:0006998)	2.21504285
96	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.21322516
97	folic acid metabolic process (GO:0046655)	2.20921347
98	mitochondrial RNA metabolic process (GO:0000959)	2.20725235
99	endoplasmic reticulum unfolded protein response (GO:0030968)	2.19343301
100	pteridine-containing compound metabolic process (GO:0042558)	2.19206863

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.79365037
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.30185839
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.23637958
4	AR_21909140_ChIP-Seq_LNCAP_Human	3.36966033
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.18891714
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.16609108
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.10992808
8	ZNF263_19887448_ChIP-Seq_K562_Human	3.02685280
9	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.86542865
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.80903507
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.78047345
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74740009
13	DCP1A_22483619_ChIP-Seq_HELA_Human	2.46073727
14	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.40305292
15	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.25018364
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.24818946
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.18794473
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16249865
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.15762802
20	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.08201499
21	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.08034479
22	KDM5A_27292631_Chip-Seq_BREAST_Human	2.05649804
23	GABP_19822575_ChIP-Seq_HepG2_Human	2.04662273
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04365758
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.03735743
26	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.02966398
27	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.97860994
28	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.88552012
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.87588942
30	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.86666450
31	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83545410
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.77824854
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.77511348
34	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.76785947
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74715041
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.74258323
37	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.71671816
38	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.71626699
39	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.64447653
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62994820
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.58795140
42	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.57006652
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55990104
44	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.55385617
45	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.50387384
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.47465486
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.46529376
48	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.45026982
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44875109
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.43785118
51	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.38578829
52	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.37676240
53	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.36615626
54	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.34715704
55	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.31432510
56	TFEB_21752829_ChIP-Seq_HELA_Human	1.29804673
57	VDR_23849224_ChIP-Seq_CD4+_Human	1.28245555
58	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28055441
59	CHD1_26751641_Chip-Seq_LNCaP_Human	1.27112307
60	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.25638277
61	GATA6_25053715_ChIP-Seq_YYC3_Human	1.25311956
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.22929414
63	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.22175709
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.21480648
65	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.20865644
66	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20530035
67	FOXP3_21729870_ChIP-Seq_TREG_Human	1.19706676
68	ATF3_27146783_Chip-Seq_COLON_Human	1.16864877
69	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.16354308
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15904538
71	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.13289200
72	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.12580842
73	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10990921
74	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.10001128
75	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.06763905
76	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.06443125
77	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.05715789
78	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.05715789
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.05432185
80	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.05346147
81	CLOCK_20551151_ChIP-Seq_293T_Human	1.04313402
82	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.04145670
83	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02224314
84	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.02114376
85	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.00590228
86	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.98347140
87	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.96942826
88	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.96336490
89	BRD4_25478319_ChIP-Seq_HGPS_Human	0.95782512
90	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.94986625
91	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.94504751
92	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.93866762
93	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.93822835
94	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.93442496
95	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.93296324
96	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91077762
97	ELF5_23300383_ChIP-Seq_T47D_Human	0.90885367
98	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.88692192
99	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.88521194
100	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.88015778

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.31935580
2	MP0003111_abnormal_nucleus_morphology	2.85035031
3	MP0004233_abnormal_muscle_weight	2.77453413
4	MP0005408_hypopigmentation	2.59239518
5	MP0001661_extended_life_span	2.42134825
6	MP0008058_abnormal_DNA_repair	2.41163370
7	MP0003077_abnormal_cell_cycle	2.30121643
8	MP0004957_abnormal_blastocyst_morpholog	2.27752700
9	MP0008057_abnormal_DNA_replication	2.26395283
10	MP0003693_abnormal_embryo_hatching	2.22160977
11	MP0002877_abnormal_melanocyte_morpholog	2.16024469
12	MP0009697_abnormal_copulation	1.97846887
13	MP0003950_abnormal_plasma_membrane	1.97366834
14	MP0008007_abnormal_cellular_replicative	1.96069521
15	MP0008932_abnormal_embryonic_tissue	1.90444755
16	MP0002160_abnormal_reproductive_system	1.88121110
17	MP0004272_abnormal_basement_membrane	1.87434146
18	MP0003806_abnormal_nucleotide_metabolis	1.84961851
19	MP0003315_abnormal_perineum_morphology	1.62702772
20	MP0005360_urolithiasis	1.62558047
21	MP0000372_irregular_coat_pigmentation	1.50991630
22	MP0003718_maternal_effect	1.47543881
23	MP0008438_abnormal_cutaneous_collagen	1.46902045
24	MP0000537_abnormal_urethra_morphology	1.42736006
25	MP0003786_premature_aging	1.40782704
26	MP0003984_embryonic_growth_retardation	1.40347667
27	MP0001672_abnormal_embryogenesis/_devel	1.40292335
28	MP0005380_embryogenesis_phenotype	1.40292335
29	MP0005171_absent_coat_pigmentation	1.39157148
30	MP0010234_abnormal_vibrissa_follicle	1.38187560
31	MP0005410_abnormal_fertilization	1.36769088
32	MP0010307_abnormal_tumor_latency	1.36236151
33	MP0002088_abnormal_embryonic_growth/wei	1.36011653
34	MP0010352_gastrointestinal_tract_polyps	1.33933220
35	MP0003566_abnormal_cell_adhesion	1.31996703
36	MP0005076_abnormal_cell_differentiation	1.27921505
37	MP0000350_abnormal_cell_proliferation	1.26307209
38	MP0005058_abnormal_lysosome_morphology	1.25445124
39	MP0009780_abnormal_chondrocyte_physiolo	1.25092959
40	MP0001730_embryonic_growth_arrest	1.24589739
41	MP0000358_abnormal_cell_content/	1.23808097
42	MP0002086_abnormal_extraembryonic_tissu	1.22693478
43	MP0001697_abnormal_embryo_size	1.22633417
44	MP0003385_abnormal_body_wall	1.19587907
45	MP0003942_abnormal_urinary_system	1.19107409
46	MP0005451_abnormal_body_composition	1.18208605
47	MP0000003_abnormal_adipose_tissue	1.17218239
48	MP0002080_prenatal_lethality	1.16819337
49	MP0003705_abnormal_hypodermis_morpholog	1.16620168
50	MP0001270_distended_abdomen	1.16547094
51	MP0000371_diluted_coat_color	1.14145224
52	MP0005257_abnormal_intraocular_pressure	1.14139220
53	MP0005409_darkened_coat_color	1.13793422
54	MP0004264_abnormal_extraembryonic_tissu	1.13074150
55	MP0003937_abnormal_limbs/digits/tail_de	1.10052010
56	MP0002084_abnormal_developmental_patter	1.06167418
57	MP0002269_muscular_atrophy	1.05314334
58	MP0003943_abnormal_hepatobiliary_system	1.03450409
59	MP0002009_preneoplasia	1.03431780
60	MP0004197_abnormal_fetal_growth/weight/	1.03401200
61	MP0005187_abnormal_penis_morphology	1.01476918
62	MP0010368_abnormal_lymphatic_system	1.00926881
63	MP0000013_abnormal_adipose_tissue	0.97489765
64	MP0000733_abnormal_muscle_development	0.95522292
65	MP0001299_abnormal_eye_distance/	0.94900301
66	MP0003868_abnormal_feces_composition	0.93928446
67	MP0002085_abnormal_embryonic_tissue	0.93690562
68	MP0001929_abnormal_gametogenesis	0.90556144
69	MP0005395_other_phenotype	0.90130006
70	MP0003123_paternal_imprinting	0.90067613
71	MP0000538_abnormal_urinary_bladder	0.89716661
72	MP0006035_abnormal_mitochondrial_morpho	0.89054533
73	MP0001849_ear_inflammation	0.87961478
74	MP0004808_abnormal_hematopoietic_stem	0.87626215
75	MP0003115_abnormal_respiratory_system	0.87188435
76	MP0000627_abnormal_mammary_gland	0.87046848
77	MP0000534_abnormal_ureter_morphology	0.86191400
78	MP0002396_abnormal_hematopoietic_system	0.85443464
79	MP0006138_congestive_heart_failure	0.85382967
80	MP0002938_white_spotting	0.84077289
81	MP0003935_abnormal_craniofacial_develop	0.84064743
82	MP0005384_cellular_phenotype	0.82166783
83	MP0001915_intracranial_hemorrhage	0.81487639
84	MP0005389_reproductive_system_phenotype	0.81037420
85	MP0005220_abnormal_exocrine_pancreas	0.79001272
86	MP0002060_abnormal_skin_morphology	0.78513067
87	MP0002108_abnormal_muscle_morphology	0.78396089
88	MP0005621_abnormal_cell_physiology	0.78129743
89	MP0005623_abnormal_meninges_morphology	0.78079882
90	MP0002075_abnormal_coat/hair_pigmentati	0.77891491
91	MP0004084_abnormal_cardiac_muscle	0.77814546
92	MP0003755_abnormal_palate_morphology	0.76045836
93	MP0000762_abnormal_tongue_morphology	0.74844246
94	MP0001186_pigmentation_phenotype	0.73548203
95	MP0001666_abnormal_nutrient_absorption	0.73259213
96	MP0002210_abnormal_sex_determination	0.72021625
97	MP0000313_abnormal_cell_death	0.70930179
98	MP0008775_abnormal_heart_ventricle	0.70506983
99	MP0001145_abnormal_male_reproductive	0.70055919
100	MP0004782_abnormal_surfactant_physiolog	0.69815967

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.51958029
2	Chromsome breakage (HP:0040012)	4.51770640
3	Asymmetry of the thorax (HP:0001555)	4.32572303
4	Small epiphyses (HP:0010585)	3.07823221
5	Abnormality of the intrinsic pathway (HP:0010989)	3.04675725
6	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.94259170
7	Deep venous thrombosis (HP:0002625)	2.88416051
8	Cutaneous melanoma (HP:0012056)	2.79844164
9	Hypopigmentation of the fundus (HP:0007894)	2.58695743
10	Ependymoma (HP:0002888)	2.51436873
11	Reduced antithrombin III activity (HP:0001976)	2.43449476
12	Abnormality of the preputium (HP:0100587)	2.43208117
13	Meckel diverticulum (HP:0002245)	2.42979796
14	Abnormality of the ileum (HP:0001549)	2.41538171
15	Abnormality of carpal bone ossification (HP:0006257)	2.31442343
16	Septate vagina (HP:0001153)	2.28070148
17	Fibular aplasia (HP:0002990)	2.27885707
18	Prolonged partial thromboplastin time (HP:0003645)	2.25927068
19	Astrocytoma (HP:0009592)	2.25205584
20	Abnormality of the astrocytes (HP:0100707)	2.25205584
21	Cerebellar dysplasia (HP:0007033)	2.24994435
22	Entropion (HP:0000621)	2.24172434
23	Mitral stenosis (HP:0001718)	2.21122057
24	Hypobetalipoproteinemia (HP:0003563)	2.20642214
25	Enlarged kidneys (HP:0000105)	2.20052650
26	Poikiloderma (HP:0001029)	2.18477622
27	Deviation of the thumb (HP:0009603)	2.16100073
28	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.15952634
29	Capillary hemangiomas (HP:0005306)	2.14460247
30	Microglossia (HP:0000171)	2.12174422
31	Spinal cord lesions (HP:0100561)	2.11731759
32	Syringomyelia (HP:0003396)	2.11731759
33	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.09286259
34	Absent epiphyses (HP:0010577)	2.09286259
35	Flat acetabular roof (HP:0003180)	2.08781937
36	Abnormality of the distal phalanges of the toes (HP:0010182)	2.03354733
37	Abnormality of the carotid arteries (HP:0005344)	2.03051450
38	Squamous cell carcinoma (HP:0002860)	2.02804569
39	Abnormality of chromosome stability (HP:0003220)	2.02464599
40	Microvesicular hepatic steatosis (HP:0001414)	2.02188853
41	Proximal placement of thumb (HP:0009623)	1.99324653
42	Type I transferrin isoform profile (HP:0003642)	1.96328009
43	Self-mutilation (HP:0000742)	1.95527616
44	Abnormality of glycolysis (HP:0004366)	1.94064825
45	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92216888
46	Abnormal protein N-linked glycosylation (HP:0012347)	1.92216888
47	Abnormal protein glycosylation (HP:0012346)	1.92216888
48	Abnormal glycosylation (HP:0012345)	1.92216888
49	Ulnar bowing (HP:0003031)	1.90719208
50	Short nail (HP:0001799)	1.87379308
51	Short chin (HP:0000331)	1.84335982
52	Limited elbow extension (HP:0001377)	1.83721521
53	Abnormal ossification of hand bones (HP:0005921)	1.81358566
54	Orthostatic hypotension (HP:0001278)	1.80842262
55	Short humerus (HP:0005792)	1.80494485
56	Glioma (HP:0009733)	1.79869316
57	Progressive external ophthalmoplegia (HP:0000590)	1.78823712
58	Myelodysplasia (HP:0002863)	1.78822209
59	Sensory axonal neuropathy (HP:0003390)	1.78573386
60	Decreased lacrimation (HP:0000633)	1.78090144
61	Pancreatic islet-cell hyperplasia (HP:0004510)	1.77853679
62	Absent radius (HP:0003974)	1.77754489
63	Hamartoma of the eye (HP:0010568)	1.77610018
64	Aplasia/hypoplasia of the humerus (HP:0006507)	1.77178439
65	Increased nuchal translucency (HP:0010880)	1.77129067
66	Premature ovarian failure (HP:0008209)	1.76479521
67	Abnormality of the nasal septum (HP:0000419)	1.76193326
68	Abnormality of the common coagulation pathway (HP:0010990)	1.76052058
69	Meningioma (HP:0002858)	1.74972317
70	Abnormality of methionine metabolism (HP:0010901)	1.73517732
71	Secondary amenorrhea (HP:0000869)	1.73029726
72	Freckling (HP:0001480)	1.71514776
73	Hyperacusis (HP:0010780)	1.70864016
74	Heterotopia (HP:0002282)	1.70768797
75	Abnormality of the acetabulum (HP:0003170)	1.69090883
76	Facial hemangioma (HP:0000329)	1.68997449
77	Cervical subluxation (HP:0003308)	1.67997743
78	Menorrhagia (HP:0000132)	1.67641792
79	Progressive muscle weakness (HP:0003323)	1.67582071
80	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.67248663
81	Insidious onset (HP:0003587)	1.65882794
82	Termporal pattern (HP:0011008)	1.65882794
83	Abnormal hand bone ossification (HP:0010660)	1.65521178
84	Aplasia involving forearm bones (HP:0009822)	1.64948457
85	Absent forearm bone (HP:0003953)	1.64948457
86	Abnormality of DNA repair (HP:0003254)	1.64481949
87	Elbow flexion contracture (HP:0002987)	1.60249949
88	Abnormality of the umbilical cord (HP:0010881)	1.60032115
89	Abnormal foot bone ossification (HP:0010675)	1.59815531
90	Abnormal tarsal ossification (HP:0008369)	1.59609601
91	Delayed closure of the anterior fontanelle (HP:0001476)	1.59255664
92	Hypothermia (HP:0002045)	1.58842616
93	Increased serum pyruvate (HP:0003542)	1.58097181
94	Clubbing of toes (HP:0100760)	1.57965335
95	Renal duplication (HP:0000075)	1.57798798
96	Sparse lateral eyebrow (HP:0005338)	1.57667701
97	Cafe-au-lait spot (HP:0000957)	1.57398674
98	Birth length less than 3rd percentile (HP:0003561)	1.55802140
99	Melanoma (HP:0002861)	1.55681969
100	Brittle hair (HP:0002299)	1.52835632

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	3.63890916
2	IRAK3	3.12818357
3	SCYL2	2.90759467
4	LATS1	2.86621044
5	PBK	2.82320467
6	EEF2K	2.68755765
7	ICK	2.54207942
8	TRIB3	2.41482701
9	EIF2AK3	2.40061555
10	MST1R	2.38807741
11	NME2	2.37556189
12	CDK12	2.25267639
13	ZAK	2.18628753
14	SRPK1	2.06588808
15	MET	1.92439533
16	TLK1	1.80772980
17	BUB1	1.77607891
18	NEK1	1.75490125
19	AKT3	1.71080565
20	EPHA2	1.70248128
21	NEK2	1.67179649
22	CDK8	1.54391940
23	MAPKAPK3	1.48605722
24	PDGFRA	1.43783520
25	BRSK2	1.32910020
26	FRK	1.29852959
27	FGFR4	1.28888568
28	PKN2	1.26983428
29	TTK	1.26485363
30	PAK4	1.20522895
31	WEE1	1.19573627
32	CHEK2	1.19107670
33	CDK7	1.18416683
34	ILK	1.17282579
35	PTK2	1.16094748
36	RPS6KB2	1.11868592
37	PINK1	1.09131546
38	TSSK6	1.07684032
39	CSNK1A1L	1.06727328
40	MTOR	1.06536251
41	PAK2	1.05655056
42	ERBB3	1.04312332
43	TRPM7	1.03368973
44	PIK3CA	0.99691974
45	WNK4	0.98783804
46	ATR	0.97219820
47	BRSK1	0.95315564
48	AURKB	0.93958599
49	ERBB4	0.88868378
50	STK38L	0.88786028
51	MYLK	0.88571308
52	LATS2	0.87520492
53	PLK1	0.86181604
54	ATM	0.80757829
55	MARK3	0.80572762
56	CCNB1	0.77021680
57	MAPK11	0.75869344
58	CHEK1	0.73411461
59	MAP3K12	0.72828832
60	FLT3	0.72592266
61	MAP3K2	0.72530100
62	CDC7	0.72358659
63	FER	0.71330044
64	STK16	0.68250565
65	MELK	0.68234119
66	CSNK1G3	0.67503869
67	STK3	0.66807683
68	PLK3	0.66481862
69	BMPR1B	0.66352026
70	PRKD3	0.65268629
71	FGFR3	0.64747106
72	CSNK1G1	0.63266211
73	AURKA	0.61663034
74	PLK4	0.60836235
75	TRIM28	0.60793803
76	BCR	0.59803947
77	NEK6	0.58981094
78	CLK1	0.54782135
79	RET	0.54183878
80	CDK1	0.53295911
81	RPS6KB1	0.53276378
82	RPS6KA5	0.51537593
83	NEK9	0.50171302
84	RAF1	0.50039550
85	IRAK2	0.46249412
86	AKT2	0.45270431
87	INSRR	0.42973068
88	STK38	0.42562356
89	CDK3	0.41819434
90	PDK2	0.39731005
91	PRKCI	0.39468775
92	CDK2	0.38518206
93	PRKAA2	0.37788075
94	NTRK1	0.35751768
95	FGFR2	0.35625011
96	EIF2AK2	0.34181579
97	DAPK1	0.33758745
98	KSR1	0.33113598
99	BRD4	0.32942696
100	MAP2K1	0.32939172

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.52319984
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.88530199
3	DNA replication_Homo sapiens_hsa03030	2.83213226
4	One carbon pool by folate_Homo sapiens_hsa00670	2.48692524
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.40808911
6	Nucleotide excision repair_Homo sapiens_hsa03420	2.11428587
7	RNA transport_Homo sapiens_hsa03013	2.08589213
8	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.08456730
9	RNA polymerase_Homo sapiens_hsa03020	2.08263880
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08168887
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.01862723
12	Mismatch repair_Homo sapiens_hsa03430	2.00201277
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.89760019
14	Homologous recombination_Homo sapiens_hsa03440	1.85828419
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.73759408
16	Cell cycle_Homo sapiens_hsa04110	1.66113574
17	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.57337708
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.50253440
19	Lysine degradation_Homo sapiens_hsa00310	1.48830558
20	Base excision repair_Homo sapiens_hsa03410	1.48517223
21	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.46245059
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.45051295
23	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.38605552
24	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.36495669
25	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.34070065
26	Proteasome_Homo sapiens_hsa03050	1.33156992
27	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.30249502
28	mRNA surveillance pathway_Homo sapiens_hsa03015	1.30012807
29	Basal transcription factors_Homo sapiens_hsa03022	1.29292953
30	Spliceosome_Homo sapiens_hsa03040	1.21898930
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.19700378
32	Other glycan degradation_Homo sapiens_hsa00511	1.17718255
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.15252223
34	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.14387178
35	Sulfur relay system_Homo sapiens_hsa04122	1.13582540
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13170481
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.12192590
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.12095155
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.09460023
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.03353759
41	Purine metabolism_Homo sapiens_hsa00230	1.03346819
42	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.00913522
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.00666632
44	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.99395171
45	Small cell lung cancer_Homo sapiens_hsa05222	0.95657937
46	p53 signaling pathway_Homo sapiens_hsa04115	0.94871605
47	Thyroid cancer_Homo sapiens_hsa05216	0.91583123
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.90827632
49	Complement and coagulation cascades_Homo sapiens_hsa04610	0.90646009
50	Alcoholism_Homo sapiens_hsa05034	0.88587545
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88153073
52	Pentose phosphate pathway_Homo sapiens_hsa00030	0.83608595
53	Propanoate metabolism_Homo sapiens_hsa00640	0.82949727
54	Glutathione metabolism_Homo sapiens_hsa00480	0.82817995
55	Carbon metabolism_Homo sapiens_hsa01200	0.82368998
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82320729
57	mTOR signaling pathway_Homo sapiens_hsa04150	0.78614443
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78356665
59	ECM-receptor interaction_Homo sapiens_hsa04512	0.78000966
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75849058
61	RNA degradation_Homo sapiens_hsa03018	0.74793998
62	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.71330770
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.71101749
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70644830
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69620437
66	Folate biosynthesis_Homo sapiens_hsa00790	0.69139673
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68900125
68	ABC transporters_Homo sapiens_hsa02010	0.68110845
69	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66848665
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.65093316
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64498969
72	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.63247848
73	Bladder cancer_Homo sapiens_hsa05219	0.62201552
74	MicroRNAs in cancer_Homo sapiens_hsa05206	0.61666998
75	Oocyte meiosis_Homo sapiens_hsa04114	0.61424121
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60440329
77	Non-small cell lung cancer_Homo sapiens_hsa05223	0.60413254
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.60100163
79	Viral carcinogenesis_Homo sapiens_hsa05203	0.52640612
80	Fatty acid elongation_Homo sapiens_hsa00062	0.52130217
81	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.50965607
82	Metabolic pathways_Homo sapiens_hsa01100	0.50798704
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49186998
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49148165
85	Circadian rhythm_Homo sapiens_hsa04710	0.48948981
86	Proteoglycans in cancer_Homo sapiens_hsa05205	0.47522650
87	Glioma_Homo sapiens_hsa05214	0.47199208
88	Prostate cancer_Homo sapiens_hsa05215	0.46875302
89	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.46250271
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46154955
91	Butanoate metabolism_Homo sapiens_hsa00650	0.44320521
92	AMPK signaling pathway_Homo sapiens_hsa04152	0.44045777
93	Fatty acid degradation_Homo sapiens_hsa00071	0.43747293
94	Melanoma_Homo sapiens_hsa05218	0.42452755
95	Adherens junction_Homo sapiens_hsa04520	0.42192962
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.41563743
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40408755
98	Pancreatic cancer_Homo sapiens_hsa05212	0.37683939
99	Focal adhesion_Homo sapiens_hsa04510	0.36957444
100	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36310644

DUXAP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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