DVL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.80459833
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80459833
3L-phenylalanine metabolic process (GO:0006558)4.69438218
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.69438218
5alpha-linolenic acid metabolic process (GO:0036109)4.51374494
6lysine metabolic process (GO:0006553)4.48426819
7lysine catabolic process (GO:0006554)4.48426819
8hemidesmosome assembly (GO:0031581)4.46802406
9negative regulation of cell size (GO:0045792)4.33166407
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.21083683
11regulation of cholesterol homeostasis (GO:2000188)4.15928058
12adherens junction assembly (GO:0034333)4.14247585
13kynurenine metabolic process (GO:0070189)4.10147902
14cysteine metabolic process (GO:0006534)4.09759283
15aromatic amino acid family catabolic process (GO:0009074)4.08596579
16urea cycle (GO:0000050)4.07320792
17urea metabolic process (GO:0019627)4.07320792
18cell-substrate adherens junction assembly (GO:0007045)4.06614865
19focal adhesion assembly (GO:0048041)4.06614865
20dicarboxylic acid biosynthetic process (GO:0043650)4.06361547
21cell-substrate junction assembly (GO:0007044)4.01042224
22cytoskeletal anchoring at plasma membrane (GO:0007016)4.00537482
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.97600048
24regulation of early endosome to late endosome transport (GO:2000641)3.91068792
25negative regulation of fibrinolysis (GO:0051918)3.86044358
26glyoxylate metabolic process (GO:0046487)3.81010375
27protein localization to endosome (GO:0036010)3.80904635
28desmosome organization (GO:0002934)3.78585110
29glutamate metabolic process (GO:0006536)3.77563603
30sulfur amino acid catabolic process (GO:0000098)3.76766254
31muscle filament sliding (GO:0030049)3.68094177
32actin-myosin filament sliding (GO:0033275)3.68094177
33nitrogen cycle metabolic process (GO:0071941)3.68011644
34activation of Rac GTPase activity (GO:0032863)3.66935377
352-oxoglutarate metabolic process (GO:0006103)3.66175008
36aspartate family amino acid catabolic process (GO:0009068)3.64998440
37bile acid biosynthetic process (GO:0006699)3.64812551
38regulation of fatty acid beta-oxidation (GO:0031998)3.57920065
39tryptophan catabolic process (GO:0006569)3.56632586
40indole-containing compound catabolic process (GO:0042436)3.56632586
41indolalkylamine catabolic process (GO:0046218)3.56632586
42negative regulation of sterol transport (GO:0032372)3.56289896
43negative regulation of cholesterol transport (GO:0032375)3.56289896
44sarcoplasmic reticulum calcium ion transport (GO:0070296)3.56009682
45high-density lipoprotein particle remodeling (GO:0034375)3.51973854
46complement activation, alternative pathway (GO:0006957)3.49476936
47cellular modified amino acid catabolic process (GO:0042219)3.49431271
48protein carboxylation (GO:0018214)3.46285864
49peptidyl-glutamic acid carboxylation (GO:0017187)3.46285864
50amino-acid betaine metabolic process (GO:0006577)3.45374817
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.44864522
52homocysteine metabolic process (GO:0050667)3.43132299
53regulation of protein activation cascade (GO:2000257)3.42780451
54skeletal muscle contraction (GO:0003009)3.41389842
55creatine metabolic process (GO:0006600)3.38007872
56protein retention in ER lumen (GO:0006621)3.37061809
57regulation of fibrinolysis (GO:0051917)3.36998529
58fatty acid transmembrane transport (GO:1902001)3.35642779
59NADH metabolic process (GO:0006734)3.35632399
60COPI coating of Golgi vesicle (GO:0048205)3.34852539
61Golgi transport vesicle coating (GO:0048200)3.34852539
62apoptotic process involved in morphogenesis (GO:0060561)3.33323868
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.33067479
64regulation of triglyceride catabolic process (GO:0010896)3.32925375
65serine family amino acid catabolic process (GO:0009071)3.32887491
66carnitine shuttle (GO:0006853)3.30982261
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.30159334
68tryptophan metabolic process (GO:0006568)3.26622799
69semaphorin-plexin signaling pathway (GO:0071526)3.25902515
70proline biosynthetic process (GO:0006561)3.24340715
71epithelial cell-cell adhesion (GO:0090136)3.23105482
72regulation of complement activation (GO:0030449)3.22027734
73drug catabolic process (GO:0042737)3.21628608
74regulation of glucose import in response to insulin stimulus (GO:2001273)3.20909279
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20494488
76regulation of mammary gland epithelial cell proliferation (GO:0033599)3.19880992
77reverse cholesterol transport (GO:0043691)3.19755523
78acetyl-CoA metabolic process (GO:0006084)3.19363550
79positive regulation of lipid catabolic process (GO:0050996)3.18938306
80alpha-amino acid catabolic process (GO:1901606)3.18611320
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15684937
82acylglycerol homeostasis (GO:0055090)3.15064353
83triglyceride homeostasis (GO:0070328)3.15064353
84bile acid metabolic process (GO:0008206)3.13179541
85amino-acid betaine transport (GO:0015838)3.12144613
86carnitine transport (GO:0015879)3.12144613
87positive regulation of myotube differentiation (GO:0010831)3.11874393
88cellular ketone body metabolic process (GO:0046950)3.11434005
89plasma lipoprotein particle clearance (GO:0034381)3.10686217
90positive regulation of synapse maturation (GO:0090129)3.05314340
91short-chain fatty acid metabolic process (GO:0046459)3.04846400
92carnitine transmembrane transport (GO:1902603)3.04004605
93phospholipid homeostasis (GO:0055091)3.03169968
94cellular amino acid catabolic process (GO:0009063)3.01455719
95ethanol oxidation (GO:0006069)2.95963601
96valine metabolic process (GO:0006573)2.95568192
97actin-mediated cell contraction (GO:0070252)2.95230458
98response to mercury ion (GO:0046689)2.91024289
99phospholipid efflux (GO:0033700)2.90594098
100regulation of fatty acid oxidation (GO:0046320)2.89709899
101protein-lipid complex remodeling (GO:0034368)2.89263784
102macromolecular complex remodeling (GO:0034367)2.89263784
103plasma lipoprotein particle remodeling (GO:0034369)2.89263784
104fatty acid beta-oxidation (GO:0006635)2.87056538
105endothelial cell chemotaxis (GO:0035767)2.86688236
106vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.86186278
107exogenous drug catabolic process (GO:0042738)2.86045105
108positive regulation of fatty acid oxidation (GO:0046321)2.85881224
109coenzyme catabolic process (GO:0009109)2.85590832
110negative regulation of fatty acid transport (GO:2000192)2.83565257
1114-hydroxyproline metabolic process (GO:0019471)2.83303403
112positive regulation of triglyceride metabolic process (GO:0090208)2.81881227
113carnitine metabolic process (GO:0009437)2.79827363
114drug transmembrane transport (GO:0006855)2.79228243
115aromatic amino acid family metabolic process (GO:0009072)2.77867668
116fatty acid oxidation (GO:0019395)2.77641368
117protein-lipid complex assembly (GO:0065005)2.76548363
118striated muscle contraction (GO:0006941)2.75783419
119dicarboxylic acid catabolic process (GO:0043649)2.74217141
120phosphate ion transmembrane transport (GO:0035435)2.73990352
121tricarboxylic acid metabolic process (GO:0072350)2.72119208
122negative regulation of skeletal muscle tissue development (GO:0048642)2.71571333
123barbed-end actin filament capping (GO:0051016)2.71522064
124lipid oxidation (GO:0034440)2.71355964
125regulation of NFAT protein import into nucleus (GO:0051532)2.70577247
126plasma membrane repair (GO:0001778)2.70507474
127fatty acid homeostasis (GO:0055089)2.69530632
128maternal placenta development (GO:0001893)2.69382279
129quaternary ammonium group transport (GO:0015697)2.69223771
130skeletal muscle fiber development (GO:0048741)2.68629548
131sarcomere organization (GO:0045214)2.68562475
132monocarboxylic acid catabolic process (GO:0072329)2.68340626
133cardiac muscle contraction (GO:0060048)2.67416740
134fatty acid catabolic process (GO:0009062)2.67256242
135plasma lipoprotein particle assembly (GO:0034377)2.66639528
136macroautophagy (GO:0016236)2.64799619
137positive regulation of fatty acid biosynthetic process (GO:0045723)2.64773499
138regulation of bile acid biosynthetic process (GO:0070857)2.64673518
139protein targeting to plasma membrane (GO:0072661)2.64497911
140ketone body metabolic process (GO:1902224)2.64371270
141cholesterol efflux (GO:0033344)2.64148932
142regulation of fatty acid biosynthetic process (GO:0042304)2.63923245
143basement membrane organization (GO:0071711)2.63665774
144cell-cell junction maintenance (GO:0045217)2.62805911
145negative regulation of lipid transport (GO:0032369)2.62411371
146oxaloacetate metabolic process (GO:0006107)2.62359450
147serine family amino acid metabolic process (GO:0009069)2.62243794
148skeletal muscle adaptation (GO:0043501)2.60318405
149gluconeogenesis (GO:0006094)2.60171102
150negative regulation of erythrocyte differentiation (GO:0045647)2.59429002
151regulation of skeletal muscle contraction (GO:0014819)2.58922270
152skin morphogenesis (GO:0043589)2.58452476
153activation of MAPKKK activity (GO:0000185)2.58358715
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57270494
155negative regulation of striated muscle cell differentiation (GO:0051154)2.55945633
156response to muscle activity (GO:0014850)2.55885103
157cardiac myofibril assembly (GO:0055003)2.55749754
158response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.55268806
159positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55100793
160sodium ion export (GO:0071436)2.53920829
161regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.53403605
162myofibril assembly (GO:0030239)2.52914768
163regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50119194
164actin filament-based movement (GO:0030048)2.49580356
165stress fiber assembly (GO:0043149)2.48882868
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.47760154
167positive regulation of receptor recycling (GO:0001921)2.44586088
168dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44341934
169negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.42481935
170glycogen catabolic process (GO:0005980)2.41930472
171peptidyl-proline hydroxylation (GO:0019511)2.40871010
172negative regulation of necroptotic process (GO:0060546)2.39826976
173hexose biosynthetic process (GO:0019319)2.39826821
174regulation of cholesterol biosynthetic process (GO:0045540)2.37964319
175atrioventricular valve morphogenesis (GO:0003181)2.37403715
176* planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37078546
177syncytium formation by plasma membrane fusion (GO:0000768)2.36804777
178proline metabolic process (GO:0006560)2.35411011
179regulation of p38MAPK cascade (GO:1900744)2.34526119
180positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33036338
181muscle cell fate commitment (GO:0042693)2.32237776
182negative regulation of potassium ion transmembrane transport (GO:1901380)2.31959712
183negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30946761
184monosaccharide biosynthetic process (GO:0046364)2.29627868
185positive regulation of protein dephosphorylation (GO:0035307)2.28573785
186cellular protein complex localization (GO:0034629)2.27893165
187regulation of translational fidelity (GO:0006450)2.27776236
188protein hydroxylation (GO:0018126)2.26795768
189activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26633748
190regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26495414
191cell volume homeostasis (GO:0006884)2.26190147
192regulation of glucocorticoid metabolic process (GO:0031943)2.26170058
193striated muscle atrophy (GO:0014891)2.25337357
194negative regulation of catenin import into nucleus (GO:0035414)2.25258499
195respiratory system process (GO:0003016)2.23990020
196endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.22384149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.30288460
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.50875778
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.04579514
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.74186823
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71846536
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.82207109
7* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.81693017
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73460040
9VDR_21846776_ChIP-Seq_THP-1_Human2.16140474
10ZNF263_19887448_ChIP-Seq_K562_Human2.10799204
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04736240
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04644772
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99092532
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97167746
15LXR_22292898_ChIP-Seq_THP-1_Human1.96773639
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91925297
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91646930
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81890840
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.81010290
20CLOCK_20551151_ChIP-Seq_293T_Human1.80456565
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73506467
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70544283
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65793022
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.61235880
25KDM2B_26808549_Chip-Seq_K562_Human1.55625722
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55001329
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54690538
28DROSHA_22980978_ChIP-Seq_HELA_Human1.53322654
29* KDM2B_26808549_Chip-Seq_DND41_Human1.52967398
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50533746
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44344045
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42838388
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42055054
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.41977174
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.37426836
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34919408
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.33438045
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33006534
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32973731
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32923486
41SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32392460
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29634918
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29207905
44TCF7_22412390_ChIP-Seq_EML_Mouse1.28453160
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27092324
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.26256861
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.26256861
48* CREB1_26743006_Chip-Seq_LNCaP_Human1.24395480
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24364343
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.21805045
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19734457
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18310848
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17621576
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17399563
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17161988
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16577271
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.15941666
58* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15933213
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15881367
60* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14575317
61* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14295144
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14203011
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12875403
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12634948
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12108452
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11646179
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11494270
68* CTCF_27219007_Chip-Seq_Bcells_Human1.10645565
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10296911
70SMC4_20622854_ChIP-Seq_HELA_Human1.10067571
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07992253
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.07949032
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.07387698
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.06999649
75P68_20966046_ChIP-Seq_HELA_Human1.06834612
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06099111
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05539555
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05406918
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05153992
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05127036
81STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04964445
82SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04832812
83NCOR1_26117541_ChIP-Seq_K562_Human1.04267408
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03994642
85EZH2_22144423_ChIP-Seq_EOC_Human1.03692967
86* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03389649
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02943011
88GATA1_19941826_ChIP-Seq_K562_Human1.02940529
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02275286
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01425653
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.01151455
92ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99747171
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98592880
94SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98564130
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98321376
96SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97616477
97HNF4A_19822575_ChIP-Seq_HepG2_Human0.96759482
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96217355
99ATF3_27146783_Chip-Seq_COLON_Human0.95827219
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95629022
101* RARA_24833708_ChIP-Seq_LIVER_Mouse0.95547018
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95352631
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95226578
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.95116538
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94458269
106TP63_22573176_ChIP-Seq_HFKS_Human0.93422584
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93249737
108TP53_23651856_ChIP-Seq_MEFs_Mouse0.92672498
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92665361
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92632060
111* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91934501
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91273645
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90444750
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.88981259
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88096309
116KLF4_19829295_ChIP-Seq_ESCs_Human0.87185527
117MYC_22102868_ChIP-Seq_BL_Human0.86794067
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86449438
119BCOR_27268052_Chip-Seq_Bcells_Human0.85003718
120* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84721667
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84484623
122* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83671681
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.83549281
124* SA1_27219007_Chip-Seq_ERYTHROID_Human0.82598706
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80719526
126* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80552248
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80482933
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79461530
129TP53_22127205_ChIP-Seq_IMR90_Human0.79309401
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.78795933
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78550779
132MYC_27129775_Chip-Seq_CORNEA_Mouse0.78228970
133* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78183078
134GATA2_19941826_ChIP-Seq_K562_Human0.77381443
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77281814
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.77097357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.82125251
2MP0005360_urolithiasis5.60720252
3MP0005085_abnormal_gallbladder_physiolo4.26012640
4MP0005365_abnormal_bile_salt4.16088637
5MP0005451_abnormal_body_composition3.51451753
6MP0003252_abnormal_bile_duct3.26456066
7MP0008875_abnormal_xenobiotic_pharmacok3.07524847
8MP0003705_abnormal_hypodermis_morpholog2.98483987
9MP0010329_abnormal_lipoprotein_level2.87269966
10MP0005083_abnormal_biliary_tract2.70582763
11MP0009840_abnormal_foam_cell2.42503963
12MP0004130_abnormal_muscle_cell2.29665084
13MP0005076_abnormal_cell_differentiation2.25725024
14MP0005332_abnormal_amino_acid2.15390025
15MP0000751_myopathy2.14301251
16MP0002877_abnormal_melanocyte_morpholog2.05271122
17MP0000678_abnormal_parathyroid_gland2.01771862
18MP0003806_abnormal_nucleotide_metabolis2.01495124
19MP0001666_abnormal_nutrient_absorption1.97557740
20MP0003453_abnormal_keratinocyte_physiol1.94917624
21MP0003195_calcinosis1.92840546
22MP0002249_abnormal_larynx_morphology1.92763368
23MP0000537_abnormal_urethra_morphology1.91500670
24MP0008961_abnormal_basal_metabolism1.87229659
25MP0010234_abnormal_vibrissa_follicle1.84485314
26MP0003191_abnormal_cellular_cholesterol1.82572864
27MP0002118_abnormal_lipid_homeostasis1.82543462
28MP0005409_darkened_coat_color1.80442397
29MP0000579_abnormal_nail_morphology1.80113435
30MP0002837_dystrophic_cardiac_calcinosis1.78848134
31MP0010030_abnormal_orbit_morphology1.68823502
32MP0004859_abnormal_synaptic_plasticity1.68237626
33MP0009780_abnormal_chondrocyte_physiolo1.66333677
34MP0000609_abnormal_liver_physiology1.66119334
35MP0004272_abnormal_basement_membrane1.65836918
36MP0004510_myositis1.63948872
37MP0000747_muscle_weakness1.61646682
38MP0005670_abnormal_white_adipose1.59925803
39MP0005058_abnormal_lysosome_morphology1.59436035
40MP0003329_amyloid_beta_deposits1.56664548
41MP0002138_abnormal_hepatobiliary_system1.55960415
42MP0003646_muscle_fatigue1.54558012
43MP0004145_abnormal_muscle_electrophysio1.52692096
44MP0005666_abnormal_adipose_tissue1.51697439
45MP0004019_abnormal_vitamin_homeostasis1.41976501
46MP0005319_abnormal_enzyme/_coenzyme1.41896228
47MP0002269_muscular_atrophy1.40748277
48MP0002060_abnormal_skin_morphology1.37290063
49MP0004087_abnormal_muscle_fiber1.36202349
50MP0000467_abnormal_esophagus_morphology1.34221114
51MP0004036_abnormal_muscle_relaxation1.33482816
52MP0000762_abnormal_tongue_morphology1.33453374
53MP0005501_abnormal_skin_physiology1.33241862
54MP0008260_abnormal_autophagy1.32442568
55MP0005584_abnormal_enzyme/coenzyme_acti1.32369210
56MP0002909_abnormal_adrenal_gland1.32267705
57MP0001348_abnormal_lacrimal_gland1.31485189
58MP0003123_paternal_imprinting1.31410549
59MP0002254_reproductive_system_inflammat1.30881020
60MP0000749_muscle_degeneration1.30682020
61MP0000604_amyloidosis1.30595880
62MP0002332_abnormal_exercise_endurance1.28624246
63MP0006138_congestive_heart_failure1.27251721
64MP0000566_synostosis1.27208408
65MP0003091_abnormal_cell_migration1.25227237
66MP0002971_abnormal_brown_adipose1.24213129
67MP0001958_emphysema1.23207385
68MP0003879_abnormal_hair_cell1.19686588
69MP0005023_abnormal_wound_healing1.19655395
70MP0005375_adipose_tissue_phenotype1.18932296
71MP0004233_abnormal_muscle_weight1.18765386
72MP0003300_gastrointestinal_ulcer1.18199673
73MP0004185_abnormal_adipocyte_glucose1.16037432
74MP0002089_abnormal_postnatal_growth/wei1.15443082
75MP0009643_abnormal_urine_homeostasis1.13852895
76MP0003868_abnormal_feces_composition1.09989891
77MP0005410_abnormal_fertilization1.09113981
78MP0003279_aneurysm1.06425995
79MP0003045_fibrosis1.05422073
80MP0005257_abnormal_intraocular_pressure1.04909578
81MP0004043_abnormal_pH_regulation1.04861439
82MP0005330_cardiomyopathy1.04306903
83MP0004084_abnormal_cardiac_muscle1.02980496
84MP0000759_abnormal_skeletal_muscle1.01322070
85MP0004858_abnormal_nervous_system1.00577648
86MP0005167_abnormal_blood-brain_barrier0.97186601
87MP0001765_abnormal_ion_homeostasis0.96846789
88MP0002078_abnormal_glucose_homeostasis0.96327525
89MP0003283_abnormal_digestive_organ0.94216030
90MP0009053_abnormal_anal_canal0.90929360
91MP0003950_abnormal_plasma_membrane0.90263402
92MP0002822_catalepsy0.90192182
93MP0000534_abnormal_ureter_morphology0.89867076
94MP0000013_abnormal_adipose_tissue0.89535101
95MP0001346_abnormal_lacrimal_gland0.89290156
96MP0009672_abnormal_birth_weight0.89102991
97MP0005535_abnormal_body_temperature0.89092212
98MP0005334_abnormal_fat_pad0.88172598
99MP0005620_abnormal_muscle_contractility0.88016662
100MP0002972_abnormal_cardiac_muscle0.87992975
101MP0003075_altered_response_to0.87654503
102MP0000003_abnormal_adipose_tissue0.86695366
103MP0002106_abnormal_muscle_physiology0.86000861
104MP0001756_abnormal_urination0.83752824
105MP0002796_impaired_skin_barrier0.82398394
106MP0001299_abnormal_eye_distance/0.81253128
107MP0001661_extended_life_span0.80911114
108MP0000598_abnormal_liver_morphology0.80593835
109MP0010352_gastrointestinal_tract_polyps0.80428672
110MP0000750_abnormal_muscle_regeneration0.79769356
111MP0000858_altered_metastatic_potential0.79106610
112MP0001216_abnormal_epidermal_layer0.78895056
113MP0008874_decreased_physiological_sensi0.76577372
114MP0004270_analgesia0.76492324
115MP0000733_abnormal_muscle_development0.73802489
116MP0002168_other_aberrant_phenotype0.72874790
117MP0005448_abnormal_energy_balance0.71944238
118MP0003656_abnormal_erythrocyte_physiolo0.71854324
119MP0000767_abnormal_smooth_muscle0.71306022
120MP0003942_abnormal_urinary_system0.71221962
121MP0005623_abnormal_meninges_morphology0.70996611
122MP0005647_abnormal_sex_gland0.70117034
123MP0010630_abnormal_cardiac_muscle0.70031518
124MP0010771_integument_phenotype0.69109796
125MP0005369_muscle_phenotype0.68429303
126MP0003385_abnormal_body_wall0.68260487
127MP0003634_abnormal_glial_cell0.67801191
128MP0001730_embryonic_growth_arrest0.67314909
129MP0005275_abnormal_skin_tensile0.66403085
130MP0005636_abnormal_mineral_homeostasis0.65921399
131MP0006036_abnormal_mitochondrial_physio0.65885234
132MP0000681_abnormal_thyroid_gland0.65496898
133MP0002098_abnormal_vibrissa_morphology0.65280650
134MP0004947_skin_inflammation0.65049077
135MP0009642_abnormal_blood_homeostasis0.62789932
136MP0002234_abnormal_pharynx_morphology0.62108755
137MP0002932_abnormal_joint_morphology0.61672400
138MP0009278_abnormal_bone_marrow0.61229175
139MP0003566_abnormal_cell_adhesion0.60820600
140MP0008438_abnormal_cutaneous_collagen0.60594710
141MP0005187_abnormal_penis_morphology0.60566144
142* MP0002114_abnormal_axial_skeleton0.60558774
143MP0009115_abnormal_fat_cell0.60330200
144MP0003690_abnormal_glial_cell0.60007581
145MP0002928_abnormal_bile_duct0.59894179
146MP0005508_abnormal_skeleton_morphology0.59860870
147MP0002896_abnormal_bone_mineralization0.58393836
148MP0001849_ear_inflammation0.57923902
149* MP0003635_abnormal_synaptic_transmissio0.57831521
150MP0005621_abnormal_cell_physiology0.56730545
151MP0002108_abnormal_muscle_morphology0.56303883
152MP0009931_abnormal_skin_appearance0.56043776
153MP0003959_abnormal_lean_body0.55819723
154MP0005166_decreased_susceptibility_to0.54868996
155MP0002970_abnormal_white_adipose0.54351045
156MP0002136_abnormal_kidney_physiology0.53457876

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.85657556
2Nemaline bodies (HP:0003798)4.47568358
3Xanthomatosis (HP:0000991)4.09695155
4Distal lower limb amyotrophy (HP:0008944)4.08685650
5Distal lower limb muscle weakness (HP:0009053)3.79272490
6Intrahepatic cholestasis (HP:0001406)3.75398906
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65926715
8Exercise-induced myalgia (HP:0003738)3.53123021
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.51563763
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.48746041
11Mildly elevated creatine phosphokinase (HP:0008180)3.34939214
12Protrusio acetabuli (HP:0003179)3.31733814
13Ketosis (HP:0001946)3.31319162
14Abnormality of the lower motor neuron (HP:0002366)3.30162635
15Lower limb amyotrophy (HP:0007210)3.25317879
16Complement deficiency (HP:0004431)3.18549744
17Hyperlipoproteinemia (HP:0010980)3.13145467
18Hypobetalipoproteinemia (HP:0003563)3.11136894
19Gout (HP:0001997)3.11077642
20Hypoalphalipoproteinemia (HP:0003233)3.02938896
21Difficulty running (HP:0009046)3.01910727
22Obstructive sleep apnea (HP:0002870)3.00122699
23Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98648814
24Hyporeflexia of lower limbs (HP:0002600)2.96063740
25Myoglobinuria (HP:0002913)2.93976789
26Spinal rigidity (HP:0003306)2.87785797
27Hypolipoproteinemia (HP:0010981)2.84866050
28Premature rupture of membranes (HP:0001788)2.84674957
29Hyperammonemia (HP:0001987)2.83758831
30Ulnar bowing (HP:0003031)2.81640505
31Abnormality of the Achilles tendon (HP:0005109)2.81038083
32Ketoacidosis (HP:0001993)2.80604273
33Type 1 muscle fiber predominance (HP:0003803)2.79456989
34Exercise-induced muscle cramps (HP:0003710)2.77582155
35Epidermoid cyst (HP:0200040)2.71216644
36Hyperglycinuria (HP:0003108)2.69490760
37Neck muscle weakness (HP:0000467)2.65159708
38EMG: myopathic abnormalities (HP:0003458)2.64173442
39Fragile skin (HP:0001030)2.62925288
40Broad face (HP:0000283)2.61194771
41Increased connective tissue (HP:0009025)2.59168540
42Stridor (HP:0010307)2.57304540
43Abnormality of serine family amino acid metabolism (HP:0010894)2.55181374
44Abnormality of glycine metabolism (HP:0010895)2.55181374
45Abnormality of the common coagulation pathway (HP:0010990)2.52905517
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50656984
47Cholelithiasis (HP:0001081)2.46389286
48Achilles tendon contracture (HP:0001771)2.43953533
49Shallow orbits (HP:0000586)2.43091778
50Upper limb amyotrophy (HP:0009129)2.39944170
51Distal upper limb amyotrophy (HP:0007149)2.39944170
52Hyperglycinemia (HP:0002154)2.39338742
53Prolonged partial thromboplastin time (HP:0003645)2.38556587
54Difficulty climbing stairs (HP:0003551)2.37641729
55Muscle fiber inclusion bodies (HP:0100299)2.37366381
56Myocardial infarction (HP:0001658)2.37247674
57Atrophic scars (HP:0001075)2.36949689
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.32693049
59Hypoglycemic coma (HP:0001325)2.31795989
60Abnormality of the left ventricular outflow tract (HP:0011103)2.31701834
61Subaortic stenosis (HP:0001682)2.31701834
62Neonatal onset (HP:0003623)2.28985377
63Bulbar palsy (HP:0001283)2.28759008
64Abnormal gallbladder physiology (HP:0012438)2.28075843
65Cholecystitis (HP:0001082)2.28075843
66Abnormality of purine metabolism (HP:0004352)2.27782862
67Abnormality of complement system (HP:0005339)2.27647870
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27558261
69Abnormal gallbladder morphology (HP:0012437)2.25036101
70Distal arthrogryposis (HP:0005684)2.23266634
71Abnormality of the calf musculature (HP:0001430)2.22388146
72Muscle fiber splitting (HP:0003555)2.19466220
73Turricephaly (HP:0000262)2.18536175
74Hypercholesterolemia (HP:0003124)2.16797187
75Hyperacusis (HP:0010780)2.16526706
76Malnutrition (HP:0004395)2.15497825
77Skin nodule (HP:0200036)2.13222230
78Back pain (HP:0003418)2.12733831
79Increased variability in muscle fiber diameter (HP:0003557)2.12594270
80Abnormality of the intrinsic pathway (HP:0010989)2.11804221
81Vertebral compression fractures (HP:0002953)2.11425406
82Cerebral aneurysm (HP:0004944)2.10879265
83Spastic diplegia (HP:0001264)2.09779479
84Abnormality of the calcaneus (HP:0008364)2.08905516
85Dysmetric saccades (HP:0000641)2.07713804
86Hyperuricemia (HP:0002149)2.06202228
87Increased purine levels (HP:0004368)2.06202228
88Mitral regurgitation (HP:0001653)2.02118220
89Calcaneovalgus deformity (HP:0001848)2.02069028
90Right ventricular cardiomyopathy (HP:0011663)2.01850732
91Abnormality of fatty-acid metabolism (HP:0004359)2.01277926
92Foot dorsiflexor weakness (HP:0009027)2.00977697
93Asymmetric septal hypertrophy (HP:0001670)2.00883137
94Hand muscle atrophy (HP:0009130)2.00744279
95Ulnar deviation of the wrist (HP:0003049)2.00559466
96Insomnia (HP:0100785)2.00553452
97Short nail (HP:0001799)1.99373456
98Generalized amyotrophy (HP:0003700)1.99347095
99Scapular winging (HP:0003691)1.97640737
100Polycythemia (HP:0001901)1.97432294
101Reticulocytosis (HP:0001923)1.95073546
102Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93822084
103Axonal loss (HP:0003447)1.93435216
104Lymphangioma (HP:0100764)1.92645007
105Slender build (HP:0001533)1.92110583
106Abnormality of skeletal muscle fiber size (HP:0012084)1.90641792
107Round ear (HP:0100830)1.90357448
108Status epilepticus (HP:0002133)1.90235032
109Cervical subluxation (HP:0003308)1.89660006
110Bundle branch block (HP:0011710)1.89621371
111Frequent falls (HP:0002359)1.88968746
112Joint hemorrhage (HP:0005261)1.88945077
113Vascular calcification (HP:0004934)1.88232754
114Long toe (HP:0010511)1.87703463
115Abnormality of nucleobase metabolism (HP:0010932)1.87627128
116Sudden death (HP:0001699)1.86289329
117Broad metatarsal (HP:0001783)1.86245904
118Cerebral inclusion bodies (HP:0100314)1.86112021
119Calf muscle hypertrophy (HP:0008981)1.85065484
120Muscle stiffness (HP:0003552)1.84838193
121EMG: neuropathic changes (HP:0003445)1.84655793
122Late onset (HP:0003584)1.84396443
123Progressive muscle weakness (HP:0003323)1.84126259
124Muscle hypertrophy of the lower extremities (HP:0008968)1.83593683
125Hydroxyprolinuria (HP:0003080)1.83496704
126Abnormality of proline metabolism (HP:0010907)1.83496704
127Aneurysm (HP:0002617)1.83362524
128Global brain atrophy (HP:0002283)1.82962170
129Fat malabsorption (HP:0002630)1.82896319
130Abnormality of the foot musculature (HP:0001436)1.82647896
131Hepatocellular carcinoma (HP:0001402)1.82182302
132Mitral valve prolapse (HP:0001634)1.82082321
133Myopathic facies (HP:0002058)1.81043041
134Ventricular tachycardia (HP:0004756)1.81036311
135Flat acetabular roof (HP:0003180)1.81013416
136Cardiovascular calcification (HP:0011915)1.80794473
137Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79616310
138Elfin facies (HP:0004428)1.79037388
139Renovascular hypertension (HP:0100817)1.78101598
140Rhabdomyolysis (HP:0003201)1.77181971
141Easy fatigability (HP:0003388)1.76443748
142Elbow flexion contracture (HP:0002987)1.75793878
143Disproportionate tall stature (HP:0001519)1.75465346
144Deformed tarsal bones (HP:0008119)1.73932150
145Bowed forearm bones (HP:0003956)1.73685490
146Bowing of the arm (HP:0006488)1.73685490
147Thin bony cortex (HP:0002753)1.72027429
148Trismus (HP:0000211)1.70758834
149Advanced eruption of teeth (HP:0006288)1.68954979
150Neurofibrillary tangles (HP:0002185)1.68399339
151Pterygium (HP:0001059)1.68249464
152Abnormal atrioventricular conduction (HP:0005150)1.67895283
153Abnormality of the distal phalanges of the toes (HP:0010182)1.66641528
154Thin ribs (HP:0000883)1.66064447
155Ankle clonus (HP:0011448)1.62885480
156Ragged-red muscle fibers (HP:0003200)1.61623064
157Bladder diverticulum (HP:0000015)1.60645865
158Long palpebral fissure (HP:0000637)1.59464191
159Metatarsus adductus (HP:0001840)1.58657445
160Milia (HP:0001056)1.57248584
161Ankle contracture (HP:0006466)1.56295575
162Reduced subcutaneous adipose tissue (HP:0003758)1.55205577
163Blue sclerae (HP:0000592)1.55067499
164Abnormality of the tricuspid valve (HP:0001702)1.55023405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.42803187
2EPHA23.28325251
3IRAK33.05289904
4PKN22.99446640
5TTN2.76351244
6SIK12.71648176
7ERN12.50372528
8RIPK12.41635975
9PRPF4B2.40439736
10SMG12.36186005
11PDK42.22697494
12PDK32.22697494
13PRKD32.22424517
14ICK2.18133811
15BCKDK2.02129529
16PTK61.97684018
17NME21.96572927
18FGFR41.93620709
19MAP3K71.74573487
20EEF2K1.71841056
21DAPK21.70178967
22MAP3K101.63261927
23ARAF1.61325434
24STK381.57663801
25PHKG11.54775827
26PHKG21.54775827
27MET1.42508321
28MAP3K91.40492789
29TYRO31.37954092
30PDGFRA1.34971318
31CAMK1G1.34918101
32KSR21.27281545
33TAOK21.25979560
34CDK121.25357780
35MAP2K41.24279509
36CAMKK11.24249035
37PAK61.22989626
38TAOK11.22218138
39SIK21.19850565
40PDK21.16021001
41OBSCN1.12103353
42EPHB11.11481757
43PAK41.10905521
44RET1.10421107
45LATS11.02185581
46BMX0.99884864
47BRAF0.98731720
48MOS0.97822392
49PTK20.97411004
50CAMK1D0.97216889
51WNK40.95705942
52LMTK20.95147897
53MAP3K110.94825204
54SGK30.94100518
55PDPK10.93134219
56NTRK10.92521095
57PRKCH0.92203974
58IRAK20.91824142
59MTOR0.90947601
60DDR20.90635936
61PDK10.89274722
62PINK10.87939111
63PRKD20.87926337
64MAP2K30.86183282
65MAP3K40.83580641
66EPHB20.83570157
67DYRK1B0.83333099
68NEK10.80376572
69RPS6KA20.79900082
70PTK2B0.79090340
71EPHA40.78921593
72MAP3K20.73882487
73PAK30.73731417
74ALK0.73628823
75PRKAA10.73367777
76MAPK120.72950290
77JAK20.72527908
78LRRK20.72314327
79DMPK0.71799542
80JAK10.70057372
81ILK0.69877936
82MAPK110.69633407
83CAMK2G0.67629369
84PIK3CG0.67594192
85STK110.67180684
86LATS20.66060443
87FER0.64616242
88MAP3K60.63451967
89CDK80.63050334
90TGFBR20.62091032
91PRKG20.62063563
92MUSK0.60082607
93PRKAA20.59340359
94WNK10.58706856
95MAPKAPK30.57180321
96RPS6KC10.57040417
97RPS6KL10.57040417
98MARK20.56977846
99FGFR20.56390817
100MST1R0.56186971
101CDK60.55025113
102LIMK10.54965544
103PAK20.54508547
104MAP3K80.54258255
105PIM20.53846530
106MAP3K30.53597428
107PDGFRB0.52799655
108MAP3K130.52129515
109PRKCZ0.51674988
110NTRK20.51605570
111FGFR30.51566877
112PRKD10.51039418
113NTRK30.50612882
114MAP2K10.50055609
115MAP2K60.49898426
116GRK60.49288742
117MINK10.48115931
118SCYL20.47111796
119CAMK2B0.46933663
120FGFR10.46280725
121MAP3K10.46227107
122CDC42BPA0.45609496
123MAP2K20.44125146
124RPS6KB20.43683582
125INSRR0.43582513
126ABL20.41736187
127RPS6KA30.41048128
128ERBB20.40110868
129CDK50.40090491
130MARK10.39941376
131PRKCI0.37668948
132AKT20.37512608
133HIPK20.36542016
134RPS6KA60.35840955
135GSK3A0.35559192
136CAMK40.35130395
137TESK10.34489843
138SGK10.33738115
139DAPK30.33100543
140MAPK40.30913760
141ROCK20.30862962
142TBK10.30860033
143MAPK100.30341697
144CAMK2D0.30010302

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.92635206
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.57860273
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.05029614
4Arginine biosynthesis_Homo sapiens_hsa002202.89160951
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39769768
6Fatty acid degradation_Homo sapiens_hsa000712.31179797
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19989011
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11612074
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.03414075
10Tryptophan metabolism_Homo sapiens_hsa003801.98388501
11Propanoate metabolism_Homo sapiens_hsa006401.94912313
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91299583
13PPAR signaling pathway_Homo sapiens_hsa033201.89995001
14Bile secretion_Homo sapiens_hsa049761.89706468
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87263124
16Butanoate metabolism_Homo sapiens_hsa006501.80445120
17Fatty acid metabolism_Homo sapiens_hsa012121.76887089
18Complement and coagulation cascades_Homo sapiens_hsa046101.72268255
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67003045
20Chronic myeloid leukemia_Homo sapiens_hsa052201.63983114
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52602581
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50602344
23Other glycan degradation_Homo sapiens_hsa005111.49962175
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46058056
25Pyruvate metabolism_Homo sapiens_hsa006201.45358989
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35037142
27Vitamin B6 metabolism_Homo sapiens_hsa007501.31309234
28* Notch signaling pathway_Homo sapiens_hsa043301.30900268
29ErbB signaling pathway_Homo sapiens_hsa040121.29086385
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27922354
31ECM-receptor interaction_Homo sapiens_hsa045121.27884999
32Carbon metabolism_Homo sapiens_hsa012001.26760335
33Non-small cell lung cancer_Homo sapiens_hsa052231.25431858
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25166501
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23126763
36Fat digestion and absorption_Homo sapiens_hsa049751.23058915
37Peroxisome_Homo sapiens_hsa041461.20764403
38Biosynthesis of amino acids_Homo sapiens_hsa012301.20298239
39Lysine degradation_Homo sapiens_hsa003101.20142168
40Fatty acid biosynthesis_Homo sapiens_hsa000611.19023656
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.17754026
42beta-Alanine metabolism_Homo sapiens_hsa004101.16889193
43Caffeine metabolism_Homo sapiens_hsa002321.16817588
44Starch and sucrose metabolism_Homo sapiens_hsa005001.14756474
45Proteoglycans in cancer_Homo sapiens_hsa052051.14374168
46Acute myeloid leukemia_Homo sapiens_hsa052211.13084799
47Endometrial cancer_Homo sapiens_hsa052131.09970912
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.09966802
49Renal cell carcinoma_Homo sapiens_hsa052111.08895105
50ABC transporters_Homo sapiens_hsa020101.08890592
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08653369
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07804730
53Thyroid cancer_Homo sapiens_hsa052161.06675318
54Selenocompound metabolism_Homo sapiens_hsa004501.06218311
55Pancreatic cancer_Homo sapiens_hsa052121.06149804
56Phenylalanine metabolism_Homo sapiens_hsa003601.02282007
57Glycerolipid metabolism_Homo sapiens_hsa005611.01858995
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.01611305
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00151027
60Insulin resistance_Homo sapiens_hsa049311.00147109
61Glucagon signaling pathway_Homo sapiens_hsa049220.97950798
62Synaptic vesicle cycle_Homo sapiens_hsa047210.95936681
63Chemical carcinogenesis_Homo sapiens_hsa052040.93729074
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92976604
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.92109380
66Adherens junction_Homo sapiens_hsa045200.90528777
67Small cell lung cancer_Homo sapiens_hsa052220.88426979
68Histidine metabolism_Homo sapiens_hsa003400.84680732
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84050129
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83138484
71Staphylococcus aureus infection_Homo sapiens_hsa051500.81067002
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.80968707
73Tight junction_Homo sapiens_hsa045300.80686936
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78866914
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72507827
76Choline metabolism in cancer_Homo sapiens_hsa052310.72390142
77AMPK signaling pathway_Homo sapiens_hsa041520.71905724
78HIF-1 signaling pathway_Homo sapiens_hsa040660.70533726
79Type II diabetes mellitus_Homo sapiens_hsa049300.70460405
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69620284
81Axon guidance_Homo sapiens_hsa043600.69297204
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.69122367
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68729971
84Vibrio cholerae infection_Homo sapiens_hsa051100.68260983
85Insulin signaling pathway_Homo sapiens_hsa049100.68151222
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68130313
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67942706
88Inositol phosphate metabolism_Homo sapiens_hsa005620.67519721
89Endocytosis_Homo sapiens_hsa041440.67212406
90MicroRNAs in cancer_Homo sapiens_hsa052060.67174596
91Tyrosine metabolism_Homo sapiens_hsa003500.66650415
92* Melanogenesis_Homo sapiens_hsa049160.66641389
93Retinol metabolism_Homo sapiens_hsa008300.66583569
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.65716736
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65670206
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.63167878
97Arginine and proline metabolism_Homo sapiens_hsa003300.62928554
98Gap junction_Homo sapiens_hsa045400.61968282
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59913374
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59307441
101MAPK signaling pathway_Homo sapiens_hsa040100.59283326
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59220790
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.57594542
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56661597
105Gastric acid secretion_Homo sapiens_hsa049710.55624617
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55536123
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55355311
108mTOR signaling pathway_Homo sapiens_hsa041500.54706803
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54317995
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.54039894
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53786996
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53249013
113Calcium signaling pathway_Homo sapiens_hsa040200.52664199
114Dilated cardiomyopathy_Homo sapiens_hsa054140.52590408
115* Hippo signaling pathway_Homo sapiens_hsa043900.52203219
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51428194
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.51300438
118Prolactin signaling pathway_Homo sapiens_hsa049170.51057519
119Rap1 signaling pathway_Homo sapiens_hsa040150.50244697
120Colorectal cancer_Homo sapiens_hsa052100.49620076
121Fructose and mannose metabolism_Homo sapiens_hsa000510.47898929
122Salivary secretion_Homo sapiens_hsa049700.47880822
123Dorso-ventral axis formation_Homo sapiens_hsa043200.45097270
124Thyroid hormone synthesis_Homo sapiens_hsa049180.44775823
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44588830
126Insulin secretion_Homo sapiens_hsa049110.44196975
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42608084
128Sulfur metabolism_Homo sapiens_hsa009200.40421834
129Vitamin digestion and absorption_Homo sapiens_hsa049770.39660211
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39530126
131Estrogen signaling pathway_Homo sapiens_hsa049150.38774985
132Renin secretion_Homo sapiens_hsa049240.38217819
133Pentose phosphate pathway_Homo sapiens_hsa000300.37544826
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37371128
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34831058
136Protein digestion and absorption_Homo sapiens_hsa049740.34800645
137Oxytocin signaling pathway_Homo sapiens_hsa049210.34578937
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.34478005
139Long-term potentiation_Homo sapiens_hsa047200.31327504
140Focal adhesion_Homo sapiens_hsa045100.30610053
141Prion diseases_Homo sapiens_hsa050200.30296736
142Glioma_Homo sapiens_hsa052140.29802738
143Amoebiasis_Homo sapiens_hsa051460.28922289
144Sulfur relay system_Homo sapiens_hsa041220.28566500
145Galactose metabolism_Homo sapiens_hsa000520.28012775
146Olfactory transduction_Homo sapiens_hsa047400.27972562
147VEGF signaling pathway_Homo sapiens_hsa043700.27889351
148GnRH signaling pathway_Homo sapiens_hsa049120.27574889
149Bladder cancer_Homo sapiens_hsa052190.27294251
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.26825109

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