DVL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.03362149
2translational termination (GO:0006415)4.84629931
3regulation of gene silencing by RNA (GO:0060966)4.83012922
4regulation of posttranscriptional gene silencing (GO:0060147)4.83012922
5regulation of gene silencing by miRNA (GO:0060964)4.83012922
6DNA unwinding involved in DNA replication (GO:0006268)4.73269763
7mitotic chromosome condensation (GO:0007076)4.31355779
8maturation of SSU-rRNA (GO:0030490)4.27088254
9ribosomal small subunit biogenesis (GO:0042274)4.23935249
10heterochromatin organization (GO:0070828)4.22310136
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17570900
12translational elongation (GO:0006414)4.15722456
13proline biosynthetic process (GO:0006561)4.12427883
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.09445277
15pre-miRNA processing (GO:0031054)4.07138510
16establishment of apical/basal cell polarity (GO:0035089)4.03466385
17nucleosome disassembly (GO:0006337)3.99912455
18protein-DNA complex disassembly (GO:0032986)3.99912455
19ribosomal large subunit biogenesis (GO:0042273)3.95520486
20translational initiation (GO:0006413)3.93605834
21* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.88275705
22paraxial mesoderm development (GO:0048339)3.85287932
23cellular protein complex disassembly (GO:0043624)3.81392954
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80010066
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67282599
26viral life cycle (GO:0019058)3.66480906
27DNA replication-dependent nucleosome organization (GO:0034723)3.65617545
28DNA replication-dependent nucleosome assembly (GO:0006335)3.65617545
29protein complex disassembly (GO:0043241)3.63606636
30protein targeting to ER (GO:0045047)3.61516518
31cotranslational protein targeting to membrane (GO:0006613)3.60693106
32protein retention in ER lumen (GO:0006621)3.55498369
33L-serine metabolic process (GO:0006563)3.53259224
34protein localization to kinetochore (GO:0034501)3.51056584
35negative regulation of mRNA processing (GO:0050686)3.50555482
36DNA replication initiation (GO:0006270)3.50428903
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46416570
38DNA strand elongation involved in DNA replication (GO:0006271)3.38338239
39negative regulation of cell size (GO:0045792)3.38096394
40macromolecular complex disassembly (GO:0032984)3.36485667
41negative regulation of RNA splicing (GO:0033119)3.35490847
42mitotic sister chromatid segregation (GO:0000070)3.31091617
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29930463
44spliceosomal tri-snRNP complex assembly (GO:0000244)3.27873213
45establishment of monopolar cell polarity (GO:0061162)3.26562255
46establishment or maintenance of monopolar cell polarity (GO:0061339)3.26562255
47protein localization to endoplasmic reticulum (GO:0070972)3.26490547
48ribosomal small subunit assembly (GO:0000028)3.25563933
49regulation of translational fidelity (GO:0006450)3.21960764
50peptidyl-arginine omega-N-methylation (GO:0035247)3.21451688
51UV protection (GO:0009650)3.20322733
52DNA replication checkpoint (GO:0000076)3.18734899
53DNA strand elongation (GO:0022616)3.18488288
54histone arginine methylation (GO:0034969)3.15979263
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.15411994
56chromatin assembly (GO:0031497)3.14822487
57nuclear pore organization (GO:0006999)3.13527326
58regulation of chromatin binding (GO:0035561)3.12614726
59polarized epithelial cell differentiation (GO:0030859)3.12414936
60negative regulation of mRNA metabolic process (GO:1903312)3.11981767
61* convergent extension (GO:0060026)3.10953064
62pentose-phosphate shunt (GO:0006098)3.10658517
63peptidyl-lysine dimethylation (GO:0018027)3.10423822
64mitotic nuclear envelope disassembly (GO:0007077)3.09761144
65telomere maintenance via semi-conservative replication (GO:0032201)3.08002955
66spliceosomal complex assembly (GO:0000245)3.05286101
67DNA strand renaturation (GO:0000733)3.04788403
68DNA duplex unwinding (GO:0032508)3.03535789
69sister chromatid segregation (GO:0000819)3.02015338
70DNA geometric change (GO:0032392)3.01061570
71folic acid-containing compound biosynthetic process (GO:0009396)3.00658625
72Golgi transport vesicle coating (GO:0048200)3.00461643
73COPI coating of Golgi vesicle (GO:0048205)3.00461643
74ncRNA 3-end processing (GO:0043628)3.00191248
75mRNA catabolic process (GO:0006402)2.99720723
76formation of translation preinitiation complex (GO:0001731)2.98719567
77intra-S DNA damage checkpoint (GO:0031573)2.96485058
78ribonucleoprotein complex biogenesis (GO:0022613)2.96328513
79histone H4-K12 acetylation (GO:0043983)2.95433335
80regulation of NFAT protein import into nucleus (GO:0051532)2.95210339
81RNA catabolic process (GO:0006401)2.94330795
823-UTR-mediated mRNA stabilization (GO:0070935)2.93505119
83adenine nucleotide transport (GO:0051503)2.92878806
84GDP-mannose metabolic process (GO:0019673)2.91118702
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90888498
86regulation of histone H3-K9 methylation (GO:0051570)2.90827418
87spliceosomal snRNP assembly (GO:0000387)2.90215612
88regulation of hippo signaling (GO:0035330)2.87761940
89proline metabolic process (GO:0006560)2.86646280
90G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.86356550
91adherens junction assembly (GO:0034333)2.86186367
92regulation of sister chromatid cohesion (GO:0007063)2.86009873
93intracellular estrogen receptor signaling pathway (GO:0030520)2.85724273
94* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85642803
95basement membrane organization (GO:0071711)2.85332631
96mRNA splicing, via spliceosome (GO:0000398)2.84524196
97RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84524196
98nuclear pore complex assembly (GO:0051292)2.83463629
99RNA splicing, via transesterification reactions (GO:0000375)2.82848992
100trophectodermal cell differentiation (GO:0001829)2.82569433
101negative regulation of histone methylation (GO:0031061)2.82111003
102protein localization to chromosome, centromeric region (GO:0071459)2.81173892
103nuclear envelope disassembly (GO:0051081)2.80461324
104membrane disassembly (GO:0030397)2.80461324
105glucose catabolic process (GO:0006007)2.80061735
106dosage compensation (GO:0007549)2.78582074
107positive regulation of SMAD protein import into nucleus (GO:0060391)2.77854935
108atrioventricular valve morphogenesis (GO:0003181)2.77718638
109apoptotic process involved in morphogenesis (GO:0060561)2.76853404
110termination of RNA polymerase II transcription (GO:0006369)2.75836779
111mRNA stabilization (GO:0048255)2.75254445
112RNA stabilization (GO:0043489)2.75254445
113regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.74904909
114lateral sprouting from an epithelium (GO:0060601)2.74047088
115regulation of gene silencing (GO:0060968)2.73050487
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.71116335
117* planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70790741
118positive regulation of chromosome segregation (GO:0051984)2.70773968
119cell-substrate adherens junction assembly (GO:0007045)2.70750437
120focal adhesion assembly (GO:0048041)2.70750437
121telomere maintenance via telomere lengthening (GO:0010833)2.70141654
122peptidyl-arginine methylation (GO:0018216)2.69834220
123peptidyl-arginine N-methylation (GO:0035246)2.69834220
124regulation of RNA export from nucleus (GO:0046831)2.69533434
125nuclear envelope reassembly (GO:0031468)2.66550881
126mitotic nuclear envelope reassembly (GO:0007084)2.66550881
127negative regulation of erythrocyte differentiation (GO:0045647)2.65482500
128mitotic recombination (GO:0006312)2.65050983
129rRNA processing (GO:0006364)2.64897561
130* regulation of establishment of planar polarity (GO:0090175)2.64894588
131rRNA transcription (GO:0009303)2.63993157
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.61804259
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61310543
134telomere maintenance via recombination (GO:0000722)2.60931107
135histone H4 deacetylation (GO:0070933)2.60903283
136NADPH regeneration (GO:0006740)2.60689136
137somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60610299
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.60610299
139head development (GO:0060322)2.59709889
140semaphorin-plexin signaling pathway (GO:0071526)2.57803645
141chromosome condensation (GO:0030261)2.57792291
142mitotic G1 DNA damage checkpoint (GO:0031571)2.57434960
143rRNA metabolic process (GO:0016072)2.56857081
144protein insertion into membrane (GO:0051205)2.55963908
145chromatin silencing (GO:0006342)2.55926707
146regulation of early endosome to late endosome transport (GO:2000641)2.55693305
147chromatin assembly or disassembly (GO:0006333)2.55124089
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54692116
149apoptotic process involved in development (GO:1902742)2.54190502
150neural tube development (GO:0021915)2.53075670
151pentose metabolic process (GO:0019321)2.52241599
152positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.50814387
153snRNA metabolic process (GO:0016073)2.50747987
154negative regulation of cell aging (GO:0090344)2.49005067
155mitochondrial fusion (GO:0008053)2.48933501
156cell-cell junction maintenance (GO:0045217)2.44547814
157purine ribonucleotide transport (GO:0015868)2.42774952
158meiotic chromosome segregation (GO:0045132)2.41970151
159stress granule assembly (GO:0034063)2.40725233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14660365
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.35388738
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.85325001
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27621114
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00024450
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95153582
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84484658
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84484658
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84484658
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69673677
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.56481761
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55585398
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45351242
14LXR_22292898_ChIP-Seq_THP-1_Human2.37873850
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32006661
16* XRN2_22483619_ChIP-Seq_HELA_Human2.28892005
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11350677
18MYC_22102868_ChIP-Seq_BL_Human2.03598348
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99451596
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97380317
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.94845452
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.91241515
23RACK7_27058665_Chip-Seq_MCF-7_Human1.88672699
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88458930
25TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87488827
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86848152
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85594451
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84379125
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84029127
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81026683
31P68_20966046_ChIP-Seq_HELA_Human1.80318262
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80084201
33TTF2_22483619_ChIP-Seq_HELA_Human1.79183305
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78726115
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77895922
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76907073
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76484757
38KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73513027
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67960324
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.67828220
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67690338
42VDR_21846776_ChIP-Seq_THP-1_Human1.66127145
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.64825290
44CIITA_25753668_ChIP-Seq_RAJI_Human1.62353754
45* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62332870
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62253394
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62187610
48* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61121393
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.60120127
50* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59318076
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59099998
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57328470
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56929244
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.56895897
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56608290
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55755540
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.55002835
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53768824
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53553279
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.52794714
61* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49262251
62DCP1A_22483619_ChIP-Seq_HELA_Human1.46361501
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46319347
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44832010
65* SA1_27219007_Chip-Seq_ERYTHROID_Human1.44615248
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43893796
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43587889
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.42806136
69KDM2B_26808549_Chip-Seq_K562_Human1.42395530
70* TP53_22127205_ChIP-Seq_IMR90_Human1.40814084
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39641173
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39226506
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.38680959
74* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37718930
75POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37568933
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36944339
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35623355
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34919898
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33075634
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31113517
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30838114
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29406946
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29397431
84AR_21909140_ChIP-Seq_LNCAP_Human1.29086374
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28069837
86KDM5A_27292631_Chip-Seq_BREAST_Human1.27915269
87CREB1_26743006_Chip-Seq_LNCaP_Human1.27697239
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.27548008
89MAF_26560356_Chip-Seq_TH2_Human1.27064484
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26487517
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.25522280
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25307880
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24090214
94FOXP3_21729870_ChIP-Seq_TREG_Human1.23942411
95* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23427725
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23159947
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22944516
98SMC4_20622854_ChIP-Seq_HELA_Human1.22069778
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20607833
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20401699
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20126351
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19909999
103* FOXP1_21924763_ChIP-Seq_HESCs_Human1.19270599
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.19227266
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18867286
106* GABP_19822575_ChIP-Seq_HepG2_Human1.18168892
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17523329
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17318958
109* VDR_23849224_ChIP-Seq_CD4+_Human1.16620627
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16013349
111* NCOR1_26117541_ChIP-Seq_K562_Human1.15807349
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.15691648
113* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15318851
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15059231
115MAF_26560356_Chip-Seq_TH1_Human1.14779362
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14546373
117* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12386045
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12243989
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12087285
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11480762
121ATF3_27146783_Chip-Seq_COLON_Human1.11405395
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.10208141
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09534479
124BCOR_27268052_Chip-Seq_Bcells_Human1.08454437
125PHF8_20622854_ChIP-Seq_HELA_Human1.07662329
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07428444
127* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07000690
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06984994
129* CTCF_27219007_Chip-Seq_Bcells_Human1.06952811
130UTX_26944678_Chip-Seq_JUKART_Human1.05829407
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05325469
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.05305747
133KDM2B_26808549_Chip-Seq_DND41_Human1.04914035
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.01486380
135ZNF263_19887448_ChIP-Seq_K562_Human1.01471263
136* TFEB_21752829_ChIP-Seq_HELA_Human1.01284709
137HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00476099
138NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98756168
139* TCF7_22412390_ChIP-Seq_EML_Mouse0.97284476
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96069106
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95174182
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95071985
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94866068
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94838777
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94121350
146NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94010488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.30514490
2MP0010030_abnormal_orbit_morphology3.09995107
3MP0003111_abnormal_nucleus_morphology2.90515297
4MP0005171_absent_coat_pigmentation2.84126722
5MP0004957_abnormal_blastocyst_morpholog2.76267822
6MP0002653_abnormal_ependyma_morphology2.61294968
7MP0010094_abnormal_chromosome_stability2.57057931
8MP0004858_abnormal_nervous_system2.56236632
9MP0003077_abnormal_cell_cycle2.45960382
10MP0000537_abnormal_urethra_morphology2.21450074
11MP0001348_abnormal_lacrimal_gland2.18930290
12MP0004133_heterotaxia2.14227029
13MP0002249_abnormal_larynx_morphology2.11125238
14MP0005076_abnormal_cell_differentiation2.04944195
15MP0008932_abnormal_embryonic_tissue2.01197116
16* MP0002085_abnormal_embryonic_tissue1.94902067
17MP0003123_paternal_imprinting1.93224840
18MP0003119_abnormal_digestive_system1.92635932
19MP0003693_abnormal_embryo_hatching1.92008834
20* MP0002084_abnormal_developmental_patter1.89613885
21MP0000350_abnormal_cell_proliferation1.86133985
22MP0005409_darkened_coat_color1.85807059
23MP0005623_abnormal_meninges_morphology1.85208563
24MP0001293_anophthalmia1.83092271
25MP0001730_embryonic_growth_arrest1.82228407
26MP0000049_abnormal_middle_ear1.82013992
27MP0002877_abnormal_melanocyte_morpholog1.80515452
28MP0003283_abnormal_digestive_organ1.76954262
29MP0001346_abnormal_lacrimal_gland1.72282169
30MP0009053_abnormal_anal_canal1.71830913
31MP0004197_abnormal_fetal_growth/weight/1.70834024
32MP0008058_abnormal_DNA_repair1.70478469
33MP0001697_abnormal_embryo_size1.67187488
34MP0000428_abnormal_craniofacial_morphol1.65611291
35* MP0005380_embryogenesis_phenotype1.62686054
36* MP0001672_abnormal_embryogenesis/_devel1.62686054
37MP0008007_abnormal_cellular_replicative1.62352186
38MP0003567_abnormal_fetal_cardiomyocyte1.60763309
39MP0002089_abnormal_postnatal_growth/wei1.59754821
40MP0003937_abnormal_limbs/digits/tail_de1.59220521
41MP0003136_yellow_coat_color1.55569047
42MP0000751_myopathy1.54472890
43MP0001661_extended_life_span1.51746266
44MP0003941_abnormal_skin_development1.50281310
45MP0005058_abnormal_lysosome_morphology1.50228870
46MP0002088_abnormal_embryonic_growth/wei1.47360131
47MP0003984_embryonic_growth_retardation1.47058213
48MP0009384_cardiac_valve_regurgitation1.45174905
49MP0010352_gastrointestinal_tract_polyps1.43318359
50MP0009278_abnormal_bone_marrow1.42985177
51MP0005451_abnormal_body_composition1.42654784
52MP0004233_abnormal_muscle_weight1.42588076
53MP0000003_abnormal_adipose_tissue1.42012078
54MP0003705_abnormal_hypodermis_morpholog1.39412956
55MP0002932_abnormal_joint_morphology1.37769437
56* MP0003385_abnormal_body_wall1.37647182
57MP0002092_abnormal_eye_morphology1.36132242
58* MP0002080_prenatal_lethality1.34014484
59MP0000467_abnormal_esophagus_morphology1.33759257
60MP0002086_abnormal_extraembryonic_tissu1.33247558
61MP0003121_genomic_imprinting1.33058664
62MP0003755_abnormal_palate_morphology1.32902008
63MP0003935_abnormal_craniofacial_develop1.32891241
64MP0003890_abnormal_embryonic-extraembry1.32245796
65* MP0002111_abnormal_tail_morphology1.31611399
66MP0002697_abnormal_eye_size1.28198104
67MP0002282_abnormal_trachea_morphology1.27740723
68MP0003786_premature_aging1.27214780
69MP0003938_abnormal_ear_development1.25973322
70MP0006292_abnormal_olfactory_placode1.24994894
71MP0008877_abnormal_DNA_methylation1.23083865
72MP0005503_abnormal_tendon_morphology1.20143681
73* MP0003861_abnormal_nervous_system1.19681761
74* MP0000432_abnormal_head_morphology1.17980481
75MP0002116_abnormal_craniofacial_bone1.17804253
76MP0009672_abnormal_birth_weight1.17601001
77MP0000762_abnormal_tongue_morphology1.17385664
78MP0003315_abnormal_perineum_morphology1.16393028
79MP0000462_abnormal_digestive_system1.15197224
80MP0001286_abnormal_eye_development1.14462309
81MP0003942_abnormal_urinary_system1.13096808
82MP0000733_abnormal_muscle_development1.12987711
83MP0003115_abnormal_respiratory_system1.12840731
84MP0009840_abnormal_foam_cell1.10788122
85MP0008995_early_reproductive_senescence1.09833789
86MP0004185_abnormal_adipocyte_glucose1.07112601
87MP0003566_abnormal_cell_adhesion1.06400732
88MP0000566_synostosis1.05464259
89MP0000678_abnormal_parathyroid_gland1.04978993
90MP0008438_abnormal_cutaneous_collagen1.04502036
91* MP0002114_abnormal_axial_skeleton1.03024606
92MP0003453_abnormal_keratinocyte_physiol1.02120187
93MP0004272_abnormal_basement_membrane1.00372988
94MP0005508_abnormal_skeleton_morphology0.99475878
95MP0001849_ear_inflammation0.98907463
96MP0009250_abnormal_appendicular_skeleto0.98165191
97MP0002233_abnormal_nose_morphology0.96834979
98MP0002938_white_spotting0.95878552
99MP0010307_abnormal_tumor_latency0.95874464
100MP0005666_abnormal_adipose_tissue0.94473631
101MP0005257_abnormal_intraocular_pressure0.94422823
102MP0000750_abnormal_muscle_regeneration0.92436458
103MP0001188_hyperpigmentation0.91061138
104MP0002210_abnormal_sex_determination0.90866501
105MP0009703_decreased_birth_body0.90177346
106MP0000313_abnormal_cell_death0.90164031
107MP0003122_maternal_imprinting0.89979701
108MP0005174_abnormal_tail_pigmentation0.89524144
109MP0001340_abnormal_eyelid_morphology0.89492014
110MP0005375_adipose_tissue_phenotype0.88872435
111MP0006072_abnormal_retinal_apoptosis0.88396515
112MP0005023_abnormal_wound_healing0.88343609
113MP0002234_abnormal_pharynx_morphology0.87998097
114MP0002177_abnormal_outer_ear0.87610520
115MP0008260_abnormal_autophagy0.87380288
116* MP0002925_abnormal_cardiovascular_devel0.86678547
117MP0005391_vision/eye_phenotype0.85109984
118MP0009379_abnormal_foot_pigmentation0.84633602
119MP0000534_abnormal_ureter_morphology0.84592755
120MP0000747_muscle_weakness0.83705275
121MP0005499_abnormal_olfactory_system0.83319233
122MP0005394_taste/olfaction_phenotype0.83319233
123MP0001145_abnormal_male_reproductive0.83222263
124MP0002075_abnormal_coat/hair_pigmentati0.81975538
125MP0003091_abnormal_cell_migration0.80795260
126MP0001915_intracranial_hemorrhage0.80343199
127MP0000759_abnormal_skeletal_muscle0.79816400
128MP0000490_abnormal_crypts_of0.79797091
129MP0005220_abnormal_exocrine_pancreas0.79669469
130MP0005501_abnormal_skin_physiology0.78838179
131MP0010630_abnormal_cardiac_muscle0.78472186
132MP0001270_distended_abdomen0.76917936
133MP0005621_abnormal_cell_physiology0.76865712
134MP0003137_abnormal_impulse_conducting0.74159627

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.79618602
2Ependymoma (HP:0002888)3.62940875
3Selective tooth agenesis (HP:0001592)3.51636446
4Rib fusion (HP:0000902)3.33455487
5Turricephaly (HP:0000262)3.26446674
6Concave nail (HP:0001598)3.17354273
7Abnormal number of incisors (HP:0011064)2.97289134
8Insomnia (HP:0100785)2.89859811
9Missing ribs (HP:0000921)2.81969292
10Broad distal phalanx of finger (HP:0009836)2.79177920
11Absent radius (HP:0003974)2.75851196
12Long palpebral fissure (HP:0000637)2.73492093
13Vertebral compression fractures (HP:0002953)2.71195754
14Absent forearm bone (HP:0003953)2.69533681
15Aplasia involving forearm bones (HP:0009822)2.69533681
16Supernumerary bones of the axial skeleton (HP:0009144)2.68088428
17Esophageal atresia (HP:0002032)2.66828389
18Supernumerary ribs (HP:0005815)2.64448282
19Shallow orbits (HP:0000586)2.63959099
20Neoplasm of striated muscle (HP:0009728)2.60990901
21Abnormality of the labia minora (HP:0012880)2.59999290
22Abnormality of the astrocytes (HP:0100707)2.58467296
23Astrocytoma (HP:0009592)2.58467296
24Testicular atrophy (HP:0000029)2.58413055
25Patellar aplasia (HP:0006443)2.49913680
26Neoplasm of the oral cavity (HP:0100649)2.48231730
27Rhabdomyosarcoma (HP:0002859)2.45277601
28Aplasia/Hypoplasia of the patella (HP:0006498)2.43239545
29Abnormal hemoglobin (HP:0011902)2.41703835
30Medulloblastoma (HP:0002885)2.41632328
31Thin bony cortex (HP:0002753)2.41448205
32Renal duplication (HP:0000075)2.40192190
33Annular pancreas (HP:0001734)2.38855504
34Vaginal fistula (HP:0004320)2.37758889
35Thin ribs (HP:0000883)2.37385383
36Abnormality of cells of the erythroid lineage (HP:0012130)2.36803805
37Abnormality of abdominal situs (HP:0011620)2.36536762
38Abdominal situs inversus (HP:0003363)2.36536762
39Poikiloderma (HP:0001029)2.30368689
40Bladder diverticulum (HP:0000015)2.29832810
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29533614
42Short 4th metacarpal (HP:0010044)2.29533614
43Macrocytic anemia (HP:0001972)2.29156050
44Supernumerary spleens (HP:0009799)2.27145041
45Pointed chin (HP:0000307)2.26700400
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25773901
47Aplasia/hypoplasia of the humerus (HP:0006507)2.23155158
48Squamous cell carcinoma (HP:0002860)2.22930021
49Overriding aorta (HP:0002623)2.22892575
50Disproportionate tall stature (HP:0001519)2.21806464
51Biconcave vertebral bodies (HP:0004586)2.21595519
52Premature rupture of membranes (HP:0001788)2.21485077
53Pallor (HP:0000980)2.21073058
54Abnormality of the distal phalanx of the thumb (HP:0009617)2.21041119
55Atresia of the external auditory canal (HP:0000413)2.20853886
56Elfin facies (HP:0004428)2.19769932
57Breast hypoplasia (HP:0003187)2.19569927
58Sparse lateral eyebrow (HP:0005338)2.19564217
59Colon cancer (HP:0003003)2.18974553
60Proximal placement of thumb (HP:0009623)2.18267979
61Protrusio acetabuli (HP:0003179)2.18251202
62Bowing of the arm (HP:0006488)2.17668652
63Bowed forearm bones (HP:0003956)2.17668652
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16944281
65Chromsome breakage (HP:0040012)2.13572268
66Absent thumb (HP:0009777)2.13309963
67Abnormality of the ileum (HP:0001549)2.12136593
68Pseudobulbar signs (HP:0002200)2.11918565
69Abnormality of the calcaneus (HP:0008364)2.11478361
70Trismus (HP:0000211)2.10468147
71Broad face (HP:0000283)2.08552577
72Cervical subluxation (HP:0003308)2.07748111
73Basal cell carcinoma (HP:0002671)2.07055635
74Spina bifida occulta (HP:0003298)2.06545229
75Large earlobe (HP:0009748)2.06501998
76Facial hemangioma (HP:0000329)2.04356888
77Partial duplication of thumb phalanx (HP:0009944)2.03668359
78Glioma (HP:0009733)2.03642688
79Abnormal sex determination (HP:0012244)2.03564393
80Sex reversal (HP:0012245)2.03564393
81Increased nuchal translucency (HP:0010880)2.03040555
82Vertebral fusion (HP:0002948)2.02487642
83Coronal craniosynostosis (HP:0004440)2.01880864
84Myopathic facies (HP:0002058)2.01044888
85Deviation of the thumb (HP:0009603)2.00862798
86Ulnar bowing (HP:0003031)2.00326277
87Rectal prolapse (HP:0002035)1.99890616
88Deep palmar crease (HP:0006191)1.99763384
89Achilles tendon contracture (HP:0001771)1.99743907
90Triphalangeal thumb (HP:0001199)1.98718758
91Meckel diverticulum (HP:0002245)1.97131727
9211 pairs of ribs (HP:0000878)1.96197688
93Mitral regurgitation (HP:0001653)1.95581974
94Short humerus (HP:0005792)1.95083450
95Abnormal number of erythroid precursors (HP:0012131)1.94574303
96Premature skin wrinkling (HP:0100678)1.93840822
97Rectovaginal fistula (HP:0000143)1.93754429
98Rectal fistula (HP:0100590)1.93754429
99Genu recurvatum (HP:0002816)1.93727985
100Neoplasm of the pancreas (HP:0002894)1.93401695
101Ankle contracture (HP:0006466)1.93343373
102Progressive muscle weakness (HP:0003323)1.92924184
103Truncus arteriosus (HP:0001660)1.91190156
104Hyperacusis (HP:0010780)1.90876849
105Gastrointestinal atresia (HP:0002589)1.90202817
106Absent epiphyses (HP:0010577)1.90070908
107Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90070908
108Abnormality of the thoracic spine (HP:0100711)1.89461927
109Metaphyseal cupping (HP:0003021)1.87713372
110Microvesicular hepatic steatosis (HP:0001414)1.87607530
111Abnormality of the 4th metacarpal (HP:0010012)1.87265380
112Long eyelashes (HP:0000527)1.87265070
113Intestinal fistula (HP:0100819)1.86985666
114Abnormality of reticulocytes (HP:0004312)1.86596034
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86545513
116Anteriorly placed anus (HP:0001545)1.86479761
117Broad palm (HP:0001169)1.85480306
118Anophthalmia (HP:0000528)1.85427544
119Partial duplication of the phalanx of hand (HP:0009999)1.85417794
120Broad thumb (HP:0011304)1.83325847
121Patellar dislocation (HP:0002999)1.82264727
122Abnormality of the salivary glands (HP:0010286)1.81887125
123Trigonocephaly (HP:0000243)1.81871837
124Skin tags (HP:0010609)1.81670514
125Slender long bone (HP:0003100)1.81526055
126Preauricular skin tag (HP:0000384)1.81351502
127Hypoplasia of the radius (HP:0002984)1.80628115
128Shawl scrotum (HP:0000049)1.79698339
129Dislocated radial head (HP:0003083)1.79406941
130Renovascular hypertension (HP:0100817)1.79205250
131Horseshoe kidney (HP:0000085)1.78470413
132Abnormality of the phalanges of the hallux (HP:0010057)1.78431063
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.76893359
134Flat cornea (HP:0007720)1.76784101
135Arnold-Chiari malformation (HP:0002308)1.76631318
136Asplenia (HP:0001746)1.76296999
137Duplicated collecting system (HP:0000081)1.75350236
138Abnormality of the fetal cardiovascular system (HP:0010948)1.75081958
139Abnormal umbilical cord blood vessels (HP:0011403)1.75081958
140Single umbilical artery (HP:0001195)1.75081958
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.74925979
142Distal upper limb amyotrophy (HP:0007149)1.74482787
143Upper limb amyotrophy (HP:0009129)1.74482787
144Abnormality of the antihelix (HP:0009738)1.73921912
145Carpal synostosis (HP:0009702)1.73536296
146Hemivertebrae (HP:0002937)1.73430440
147Cerebral aneurysm (HP:0004944)1.72994929
148Abnormality of the radial head (HP:0003995)1.71974057
149Ectopic kidney (HP:0000086)1.71590238
150Broad phalanges of the hand (HP:0009768)1.71148174
151Short thumb (HP:0009778)1.71054990
152Tracheoesophageal fistula (HP:0002575)1.71043666
153High anterior hairline (HP:0009890)1.70640481
154Mesangial abnormality (HP:0001966)1.70613939
155Volvulus (HP:0002580)1.70535786
156Skull defect (HP:0001362)1.69901653
157Duplication of thumb phalanx (HP:0009942)1.69145884
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.69085173
159Joint stiffness (HP:0001387)1.66883884
160Capillary hemangiomas (HP:0005306)1.65299267
161Reticulocytosis (HP:0001923)1.63054419
162Broad metatarsal (HP:0001783)1.62464746
163Broad finger (HP:0001500)1.62449681
164Asymmetry of the thorax (HP:0001555)1.62330906
165Fragile skin (HP:0001030)1.61652247
166Delayed epiphyseal ossification (HP:0002663)1.61332201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.65489461
2SMG14.52068750
3CDK124.26289193
4ICK3.19608378
5CDC73.17368486
6MAP3K103.14344088
7EEF2K2.92211829
8CDK72.27078948
9ERN12.26464746
10NEK22.23798357
11WEE12.18768682
12BUB12.18121263
13TTK2.17808575
14PRPF4B2.02260903
15PASK1.98663060
16RPS6KB21.87326714
17BRD41.86265399
18VRK21.82748490
19EPHA21.68055070
20IRAK31.62829980
21LATS21.53840652
22DDR21.52065713
23* PLK11.50794280
24FGFR41.50624444
25MKNK11.46454559
26SRPK11.46014422
27MKNK21.43801704
28PDGFRA1.40461278
29TYRO31.39118699
30MTOR1.37701491
31EPHB21.37623875
32CHEK21.32745620
33CDK41.31776810
34STK101.29278985
35PKN21.28263188
36DYRK31.25339996
37MAP2K31.22679490
38BMX1.20815468
39ATR1.20064889
40UHMK11.19668012
41CHEK11.17273542
42MAP3K111.17240287
43TTN1.16628570
44AURKA1.15207060
45AURKB1.14698433
46MAP3K81.11067248
47TRIB31.10150617
48BRAF1.08927487
49PNCK1.07865457
50PTK61.03710690
51ALK1.02839453
52PAK41.02668138
53PRKD31.01839100
54CDK21.01805625
55TAF11.01740271
56ARAF1.00436330
57STK40.99335063
58SIK20.95079341
59PIM20.94813805
60RPS6KA20.94441078
61TESK20.94066995
62PAK20.93502088
63TSSK60.93103134
64MARK20.90622901
65MAPK110.89400670
66PRKD20.89387763
67LATS10.88653440
68ATM0.88580900
69TAOK20.84136872
70TESK10.82579773
71NME20.80360068
72VRK10.80355406
73CLK10.78453363
74MAP2K20.76661447
75TGFBR10.76632482
76CAMK1D0.76304103
77AKT20.75315003
78RPS6KA60.74520584
79PRKCI0.73976472
80RIPK10.72667208
81* CSNK1E0.71943684
82PAK10.70971183
83LMTK20.70511198
84PBK0.69460971
85FGR0.67936320
86PTK20.67573958
87MAP3K130.67112178
88CDK10.66322401
89DYRK1B0.65736162
90STK30.64940845
91PIM10.64077832
92LRRK20.63472934
93GRK60.61978532
94CDK11A0.61535358
95BRSK10.61378684
96IRAK20.61321131
97MAP3K70.60569310
98MAPK150.60124311
99CDK190.59878455
100DAPK30.59605937
101SCYL20.58040680
102CSNK2A20.58018805
103CDK90.57842065
104KDR0.57185084
105NTRK10.57008006
106HIPK20.56676233
107CAMK1G0.55911809
108CDK150.55225724
109ILK0.53692141
110PRKDC0.53391821
111EIF2AK10.52148199
112KSR20.51384401
113SIK10.51075181
114MET0.50364063
115ERBB20.50102011
116FGFR10.49469154
117KSR10.49378103
118RPS6KL10.49234474
119RPS6KC10.49234474
120RPS6KA10.48191111
121MAPK10.47461859
122MATK0.46998691
123PDPK10.46498710
124CDK180.45622725
125CDK60.45587231
126CDC42BPA0.44544543
127AKT10.44484938
128DMPK0.43844372
129CDK80.43733120
130MELK0.43007970
131RPS6KA40.42523350
132CDK140.42508795
133FLT30.41944695
134BCKDK0.41055165
135DYRK20.41025758
136RPS6KA50.40803353
137* CSNK1D0.40394292
138MAP3K60.39954150
139MAPK140.39083243
140MOS0.38651100
141RET0.34662150

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.28168238
2DNA replication_Homo sapiens_hsa030304.01856545
3Mismatch repair_Homo sapiens_hsa034303.75011630
4Spliceosome_Homo sapiens_hsa030403.60718706
5RNA transport_Homo sapiens_hsa030132.90657858
6Homologous recombination_Homo sapiens_hsa034402.83226910
7Base excision repair_Homo sapiens_hsa034102.82185516
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75278303
9One carbon pool by folate_Homo sapiens_hsa006702.51902865
10mRNA surveillance pathway_Homo sapiens_hsa030152.40180086
11Cell cycle_Homo sapiens_hsa041102.39770998
12Nucleotide excision repair_Homo sapiens_hsa034202.37148926
13Fanconi anemia pathway_Homo sapiens_hsa034602.34758959
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.34654329
15RNA polymerase_Homo sapiens_hsa030202.31251307
16* Basal cell carcinoma_Homo sapiens_hsa052172.17206104
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09280287
18Hedgehog signaling pathway_Homo sapiens_hsa043401.87648810
19Pentose phosphate pathway_Homo sapiens_hsa000301.80762567
20Fructose and mannose metabolism_Homo sapiens_hsa000511.73572580
21* Notch signaling pathway_Homo sapiens_hsa043301.62524187
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62522840
23* Hippo signaling pathway_Homo sapiens_hsa043901.58587959
24Non-homologous end-joining_Homo sapiens_hsa034501.53079939
25RNA degradation_Homo sapiens_hsa030181.52224011
26* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49348543
27Other glycan degradation_Homo sapiens_hsa005111.48892166
28Pyrimidine metabolism_Homo sapiens_hsa002401.45872560
29p53 signaling pathway_Homo sapiens_hsa041151.42296897
30MicroRNAs in cancer_Homo sapiens_hsa052061.42254491
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39624483
32Lysine degradation_Homo sapiens_hsa003101.39410630
33Bladder cancer_Homo sapiens_hsa052191.37100904
34Basal transcription factors_Homo sapiens_hsa030221.36603617
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.29658802
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24770237
37Sulfur relay system_Homo sapiens_hsa041221.23513932
38Carbon metabolism_Homo sapiens_hsa012001.15168585
39Systemic lupus erythematosus_Homo sapiens_hsa053221.15040133
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09684626
41* Wnt signaling pathway_Homo sapiens_hsa043101.07267712
42TGF-beta signaling pathway_Homo sapiens_hsa043501.06399357
43* HTLV-I infection_Homo sapiens_hsa051661.02910280
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.01457819
45N-Glycan biosynthesis_Homo sapiens_hsa005101.00266476
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99658013
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.99449439
48Viral carcinogenesis_Homo sapiens_hsa052030.97515639
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97306455
50Galactose metabolism_Homo sapiens_hsa000520.95649865
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95212795
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94466664
53Adherens junction_Homo sapiens_hsa045200.93805570
54Small cell lung cancer_Homo sapiens_hsa052220.93667289
55Oocyte meiosis_Homo sapiens_hsa041140.92530631
56Insulin signaling pathway_Homo sapiens_hsa049100.90049020
57Chronic myeloid leukemia_Homo sapiens_hsa052200.88120043
58Huntingtons disease_Homo sapiens_hsa050160.85802277
59Tight junction_Homo sapiens_hsa045300.83956856
60Epstein-Barr virus infection_Homo sapiens_hsa051690.83840534
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83547578
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82816245
63Proteoglycans in cancer_Homo sapiens_hsa052050.80183275
64* Pathways in cancer_Homo sapiens_hsa052000.79002195
65Thyroid cancer_Homo sapiens_hsa052160.76271435
66Colorectal cancer_Homo sapiens_hsa052100.75506370
67Inositol phosphate metabolism_Homo sapiens_hsa005620.74764228
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.74422983
69mTOR signaling pathway_Homo sapiens_hsa041500.68974024
70ECM-receptor interaction_Homo sapiens_hsa045120.65906168
71Prion diseases_Homo sapiens_hsa050200.62745565
72Renal cell carcinoma_Homo sapiens_hsa052110.61578632
73Parkinsons disease_Homo sapiens_hsa050120.61426310
74Prostate cancer_Homo sapiens_hsa052150.61338227
75Herpes simplex infection_Homo sapiens_hsa051680.61187245
76Alcoholism_Homo sapiens_hsa050340.60888477
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60763296
78Acute myeloid leukemia_Homo sapiens_hsa052210.58885684
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58582956
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54999622
81Choline metabolism in cancer_Homo sapiens_hsa052310.54705761
82Focal adhesion_Homo sapiens_hsa045100.54457333
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53514518
84Purine metabolism_Homo sapiens_hsa002300.53399778
85Axon guidance_Homo sapiens_hsa043600.52743359
86Melanoma_Homo sapiens_hsa052180.51948787
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51885754
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51788601
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51265248
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50324325
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50099127
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.48750567
93Biosynthesis of amino acids_Homo sapiens_hsa012300.48734728
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48724090
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47882603
96Proteasome_Homo sapiens_hsa030500.47047791
97Pyruvate metabolism_Homo sapiens_hsa006200.46935393
98Non-small cell lung cancer_Homo sapiens_hsa052230.46866276
99Viral myocarditis_Homo sapiens_hsa054160.46581880
100Selenocompound metabolism_Homo sapiens_hsa004500.46285592
101Cardiac muscle contraction_Homo sapiens_hsa042600.45449268
102VEGF signaling pathway_Homo sapiens_hsa043700.44177208
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43987857
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43870549
105* Melanogenesis_Homo sapiens_hsa049160.43655771
106Dorso-ventral axis formation_Homo sapiens_hsa043200.40626729
107Oxidative phosphorylation_Homo sapiens_hsa001900.38766021
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37913169
109HIF-1 signaling pathway_Homo sapiens_hsa040660.33674786
110ErbB signaling pathway_Homo sapiens_hsa040120.33058279
111Endometrial cancer_Homo sapiens_hsa052130.32946460
112AMPK signaling pathway_Homo sapiens_hsa041520.32152439
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31628671
114Hepatitis B_Homo sapiens_hsa051610.30412941
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29577927
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29227452
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28797888
118Alzheimers disease_Homo sapiens_hsa050100.28464874
119Apoptosis_Homo sapiens_hsa042100.28334043
120Rap1 signaling pathway_Homo sapiens_hsa040150.28256048
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28025842
122Antigen processing and presentation_Homo sapiens_hsa046120.27503623
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24721775
124Glioma_Homo sapiens_hsa052140.24546030
125Folate biosynthesis_Homo sapiens_hsa007900.23739465
126Estrogen signaling pathway_Homo sapiens_hsa049150.23016620
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22600896
128Dilated cardiomyopathy_Homo sapiens_hsa054140.21635172
129Pancreatic cancer_Homo sapiens_hsa052120.21141384
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20422102
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19255871

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