DVL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)4.44407779
2COPI coating of Golgi vesicle (GO:0048205)4.25442912
3Golgi transport vesicle coating (GO:0048200)4.25442912
4regulation of NFAT protein import into nucleus (GO:0051532)4.00361932
5paraxial mesoderm development (GO:0048339)3.93098359
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.85717679
7axon extension involved in axon guidance (GO:0048846)3.85717679
8semaphorin-plexin signaling pathway (GO:0071526)3.83359663
9adherens junction assembly (GO:0034333)3.82953114
10protein retention in ER lumen (GO:0006621)3.74995925
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74902138
12myofibril assembly (GO:0030239)3.68762902
13basement membrane organization (GO:0071711)3.57223407
14sarcomere organization (GO:0045214)3.55926793
15focal adhesion assembly (GO:0048041)3.55912892
16cell-substrate adherens junction assembly (GO:0007045)3.55912892
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.49103731
18regulation of early endosome to late endosome transport (GO:2000641)3.35910018
19desmosome organization (GO:0002934)3.31242902
20insulin-like growth factor receptor signaling pathway (GO:0048009)3.31186333
21epithelial cell-cell adhesion (GO:0090136)3.21896600
22skin morphogenesis (GO:0043589)3.21711131
23regulation of glucose import in response to insulin stimulus (GO:2001273)3.21015744
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18452373
25atrial septum morphogenesis (GO:0060413)3.18030353
26actomyosin structure organization (GO:0031032)3.17563277
27cell-substrate junction assembly (GO:0007044)3.15802391
28plasma membrane repair (GO:0001778)3.11393938
29protein localization to endosome (GO:0036010)3.04023157
30positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.03712251
31maternal placenta development (GO:0001893)3.02234335
32cell-cell junction maintenance (GO:0045217)2.98159844
33hippo signaling (GO:0035329)2.95809669
34negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.95495442
35positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.94662423
36endothelial cell chemotaxis (GO:0035767)2.92954549
37stress fiber assembly (GO:0043149)2.91289677
38cell communication by electrical coupling (GO:0010644)2.90597635
39cardiac muscle hypertrophy (GO:0003300)2.90042911
40establishment of nucleus localization (GO:0040023)2.88208763
41cardiac muscle contraction (GO:0060048)2.85895003
42regulation of extracellular matrix disassembly (GO:0010715)2.85814083
43cell proliferation involved in metanephros development (GO:0072203)2.85612290
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84613211
45glucocorticoid receptor signaling pathway (GO:0042921)2.84230328
46negative regulation of erythrocyte differentiation (GO:0045647)2.82732732
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.77749584
48vascular endothelial growth factor signaling pathway (GO:0038084)2.76361598
49apoptotic process involved in morphogenesis (GO:0060561)2.76016165
50mannose metabolic process (GO:0006013)2.73664802
51cardiac cell development (GO:0055006)2.73560003
52nucleus localization (GO:0051647)2.73407460
53negative regulation of potassium ion transmembrane transport (GO:1901380)2.71540638
54striated muscle hypertrophy (GO:0014897)2.70907667
55regulation of histone H3-K27 methylation (GO:0061085)2.69520181
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69148412
57epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68964598
58heart morphogenesis (GO:0003007)2.68294996
59embryonic foregut morphogenesis (GO:0048617)2.66666253
60response to pheromone (GO:0019236)2.65952765
61barbed-end actin filament capping (GO:0051016)2.65464047
62cardiac muscle cell development (GO:0055013)2.64971044
63mesenchyme morphogenesis (GO:0072132)2.63407516
64spinal cord development (GO:0021510)2.63011704
65muscle filament sliding (GO:0030049)2.62443580
66actin-myosin filament sliding (GO:0033275)2.62443580
67ventricular trabecula myocardium morphogenesis (GO:0003222)2.60945596
68embryonic eye morphogenesis (GO:0048048)2.59617758
69membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.59540505
70notochord development (GO:0030903)2.58267059
71cardiac muscle adaptation (GO:0014887)2.57529242
72cardiac muscle hypertrophy in response to stress (GO:0014898)2.57529242
73muscle hypertrophy in response to stress (GO:0003299)2.57529242
74myotube differentiation (GO:0014902)2.57320369
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57202817
76branching involved in mammary gland duct morphogenesis (GO:0060444)2.56827116
77pyrimidine nucleobase catabolic process (GO:0006208)2.56325536
78cardiac chamber formation (GO:0003207)2.55960274
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55866516
80* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54988421
81* planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52782257
82regulation of cardioblast differentiation (GO:0051890)2.52418868
83eye morphogenesis (GO:0048592)2.52208289
84negative regulation of striated muscle cell apoptotic process (GO:0010664)2.52192938
85activation of Rac GTPase activity (GO:0032863)2.51776936
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51528284
87histone H3-K4 trimethylation (GO:0080182)2.51075685
88cell migration in hindbrain (GO:0021535)2.49911652
89adult heart development (GO:0007512)2.49219415
90intracellular estrogen receptor signaling pathway (GO:0030520)2.49213511
91endocardial cushion morphogenesis (GO:0003203)2.49036590
92protein targeting to plasma membrane (GO:0072661)2.48862018
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48525490
94regulation of cholesterol homeostasis (GO:2000188)2.47784389
95* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46293158
96negative regulation of fatty acid transport (GO:2000192)2.45884872
97camera-type eye morphogenesis (GO:0048593)2.45545876
98central nervous system projection neuron axonogenesis (GO:0021952)2.44946119
99ventricular cardiac muscle cell action potential (GO:0086005)2.44802297
100cardiac muscle tissue morphogenesis (GO:0055008)2.44787440
101ganglion development (GO:0061548)2.44221255
102negative regulation of catenin import into nucleus (GO:0035414)2.43172487
103positive regulation of nuclease activity (GO:0032075)2.42903543
104response to laminar fluid shear stress (GO:0034616)2.42802124
105* regulation of establishment of planar polarity (GO:0090175)2.42368724
106atrioventricular valve morphogenesis (GO:0003181)2.41978333
107protein heterotrimerization (GO:0070208)2.41713889
108embryonic camera-type eye development (GO:0031076)2.41695238
109chondrocyte proliferation (GO:0035988)2.40649842
110regulation of nucleobase-containing compound transport (GO:0032239)2.39732398
111embryonic process involved in female pregnancy (GO:0060136)2.39571989
112ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.39363624
113actin-mediated cell contraction (GO:0070252)2.39334620
114cellular response to epidermal growth factor stimulus (GO:0071364)2.38404233
115collagen fibril organization (GO:0030199)2.38268504
116regulation of membrane repolarization (GO:0060306)2.38262820
117myoblast fusion (GO:0007520)2.37285164
118regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.37230320
119hemidesmosome assembly (GO:0031581)2.34554662
120vesicle coating (GO:0006901)2.34463641
121muscle hypertrophy (GO:0014896)2.33746983
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.32855595
123bone trabecula formation (GO:0060346)2.32651177
124positive regulation of glycogen biosynthetic process (GO:0045725)2.32537144
125venous blood vessel morphogenesis (GO:0048845)2.32014156
126histone H3-K4 methylation (GO:0051568)2.32006393
127ear development (GO:0043583)2.30741128
128synaptic vesicle docking involved in exocytosis (GO:0016081)2.29787350
129regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29762434
130cell junction maintenance (GO:0034331)2.29459561
131pre-miRNA processing (GO:0031054)2.28854501
132cardiac ventricle formation (GO:0003211)2.28256536
133fibroblast migration (GO:0010761)2.28205728
134* cochlea morphogenesis (GO:0090103)2.27991892
135regulation of fatty acid beta-oxidation (GO:0031998)2.27854684
136regulation of hippo signaling (GO:0035330)2.27649009
137regulation of endothelial cell chemotaxis (GO:2001026)2.27574804
138metanephric mesenchyme development (GO:0072075)2.26829748
139regulation of G0 to G1 transition (GO:0070316)2.26696854
140positive regulation of myoblast differentiation (GO:0045663)2.26017982
141establishment of apical/basal cell polarity (GO:0035089)2.25766974
142regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.25709309
143neural tube development (GO:0021915)2.25120341
144negative regulation of chondrocyte differentiation (GO:0032331)2.24799219
145dosage compensation (GO:0007549)2.24277302
146membrane repolarization during action potential (GO:0086011)2.24229952
147actin filament-based movement (GO:0030048)2.24075216
148negative regulation of cell size (GO:0045792)2.23732445
149regulation of RNA export from nucleus (GO:0046831)2.23376650
150adherens junction organization (GO:0034332)2.23109721
151receptor recycling (GO:0001881)2.22921845
152positive regulation of receptor recycling (GO:0001921)2.22915317
153cardiac muscle cell proliferation (GO:0060038)2.22248001
154heart valve formation (GO:0003188)2.22167046
155endocytic recycling (GO:0032456)2.21818049
156modulation by virus of host morphology or physiology (GO:0019048)2.21808785
157embryo implantation (GO:0007566)2.21691937
158regulation of heart rate by cardiac conduction (GO:0086091)2.21507541
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20916752
160negative regulation of stem cell proliferation (GO:2000647)2.20393410
161morphogenesis of an epithelial sheet (GO:0002011)2.19851713
162interkinetic nuclear migration (GO:0022027)2.19423605
163positive regulation of epithelial to mesenchymal transition (GO:0010718)2.19246754
164epithelial cell fate commitment (GO:0072148)2.19243965
165cell migration involved in heart development (GO:0060973)2.19073032
166cardiac conduction (GO:0061337)2.19047193
167positive regulation of stem cell differentiation (GO:2000738)2.18459413
168striated muscle contraction (GO:0006941)2.18402198
169proline biosynthetic process (GO:0006561)2.17490604
170negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17485443
171endoplasmic reticulum unfolded protein response (GO:0030968)2.17233977
172lateral sprouting from an epithelium (GO:0060601)2.17165794
173cell communication involved in cardiac conduction (GO:0086065)2.16942000
174embryonic camera-type eye morphogenesis (GO:0048596)2.16884817
175endodermal cell differentiation (GO:0035987)2.16708202
176muscle tissue morphogenesis (GO:0060415)2.16704446
177ER-nucleus signaling pathway (GO:0006984)2.16664644
178corticosteroid receptor signaling pathway (GO:0031958)2.16407868
179regulation of extracellular matrix organization (GO:1903053)2.15732626
180positive regulation of extracellular matrix organization (GO:1903055)2.15410772
181peptidyl-proline hydroxylation (GO:0019511)2.14905178
182response to epidermal growth factor (GO:0070849)2.13799389
183regulation of ARF GTPase activity (GO:0032312)2.11937039
184actin filament bundle organization (GO:0061572)2.11754761
185actin filament bundle assembly (GO:0051017)2.11754761
186activation of MAPKKK activity (GO:0000185)2.11394055
187placenta blood vessel development (GO:0060674)2.11359300
188positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11240348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.85392552
2EZH2_22144423_ChIP-Seq_EOC_Human2.82496405
3EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.79268339
4LXR_22292898_ChIP-Seq_THP-1_Human2.60004281
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.55073514
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.48949804
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.47282433
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43254893
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.41076683
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.33959400
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.21905337
12DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.21056139
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19584613
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18218474
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14188217
16CLOCK_20551151_ChIP-Seq_293T_Human2.12693832
17ZNF263_19887448_ChIP-Seq_K562_Human2.07163483
18ISL1_27105846_Chip-Seq_CPCs_Mouse2.00278688
19ZFP281_27345836_Chip-Seq_ESCs_Mouse1.97753457
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.94888288
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94327361
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.93315768
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91279892
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89245678
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89245678
26DROSHA_22980978_ChIP-Seq_HELA_Human1.84735843
27VDR_21846776_ChIP-Seq_THP-1_Human1.84344499
28KDM2B_26808549_Chip-Seq_K562_Human1.82788263
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.82657054
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82473748
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.79732544
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.74367431
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71932390
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69595928
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65577426
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65307232
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64157213
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64056648
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63726977
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61351836
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60871411
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.58279956
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.57457030
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55448425
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55060019
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54710553
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51868950
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.51841201
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51597927
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.50042766
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49801926
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48523565
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46527663
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45403327
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.45152664
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44040753
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42569142
58AHR_22903824_ChIP-Seq_MCF-7_Human1.42182166
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.39631410
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.39626323
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38624697
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38547342
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38059049
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37978070
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37604762
66GBX2_23144817_ChIP-Seq_PC3_Human1.37576494
67KDM2B_26808549_Chip-Seq_DND41_Human1.37300831
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36915576
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35889076
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34595832
71* AR_19668381_ChIP-Seq_PC3_Human1.33850500
72* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32306076
73SMC4_20622854_ChIP-Seq_HELA_Human1.31766442
74* TP53_20018659_ChIP-ChIP_R1E_Mouse1.30058582
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28936501
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28453784
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27887704
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27809867
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27741340
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27536879
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.26613052
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.26613052
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26024072
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25660435
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.25164645
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24227437
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.23041300
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21879003
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21566211
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.21079283
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.20663251
92TP53_22127205_ChIP-Seq_IMR90_Human1.20646941
93MYC_22102868_ChIP-Seq_BL_Human1.20393006
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19968486
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19717069
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.18324976
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18236701
98* TP53_23651856_ChIP-Seq_MEFs_Mouse1.17691881
99ATF3_27146783_Chip-Seq_COLON_Human1.17397203
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17321597
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16985017
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.16768669
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16471468
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16290098
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.15589870
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15243282
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14359749
108P68_20966046_ChIP-Seq_HELA_Human1.13520518
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13430357
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.11397843
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11137700
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11047526
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10163334
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09785289
115TCF7_22412390_ChIP-Seq_EML_Mouse1.08847313
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.07946190
117BRD4_25478319_ChIP-Seq_HGPS_Human1.07507295
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06919458
119CTCF_27219007_Chip-Seq_Bcells_Human1.06652500
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.04804919
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04509824
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04305799
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04292772
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03934074
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.03283283
126NCOR1_26117541_ChIP-Seq_K562_Human1.02438379
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02346972
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01970602
129TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01588202
130GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01038705
131* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00953265
132* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00861084
133* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00818807
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00730646
135ESR2_21235772_ChIP-Seq_MCF-7_Human1.00727784
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00631866
137RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00577497
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00473605
139TP63_17297297_ChIP-ChIP_HaCaT_Human1.00243715
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99787342
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98532926
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98097899
143SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98010413
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97755397
145SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96308543
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96099570
147SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95663630
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.95458885
149FOXM1_23109430_ChIP-Seq_U2OS_Human0.95084777
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.94668850
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94617969
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94254479
153ESR1_21235772_ChIP-Seq_MCF-7_Human0.94004217
154CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93176874
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92319305
156MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91725930
157CREB1_26743006_Chip-Seq_LNCaP_Human0.90198460
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.89378887
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89297854
160MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89160132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.15558503
2MP0010030_abnormal_orbit_morphology3.11001762
3MP0003122_maternal_imprinting2.82896536
4MP0005409_darkened_coat_color2.66787870
5MP0003705_abnormal_hypodermis_morpholog2.51363779
6MP0002653_abnormal_ependyma_morphology2.42416763
7MP0009780_abnormal_chondrocyte_physiolo2.41985206
8MP0004084_abnormal_cardiac_muscle2.39851952
9MP0005275_abnormal_skin_tensile2.34319075
10MP0000569_abnormal_digit_pigmentation2.31301579
11MP0009053_abnormal_anal_canal2.17261283
12MP0003121_genomic_imprinting2.16709148
13MP0005058_abnormal_lysosome_morphology2.06021460
14MP0005451_abnormal_body_composition2.03011335
15MP0000537_abnormal_urethra_morphology2.02016572
16MP0001958_emphysema1.97863115
17MP0000751_myopathy1.95813062
18MP0005503_abnormal_tendon_morphology1.91073969
19MP0002877_abnormal_melanocyte_morpholog1.89195984
20MP0003091_abnormal_cell_migration1.87919211
21MP0003787_abnormal_imprinting1.84582830
22MP0003385_abnormal_body_wall1.80533030
23MP0003283_abnormal_digestive_organ1.78663412
24MP0010234_abnormal_vibrissa_follicle1.76586080
25MP0002837_dystrophic_cardiac_calcinosis1.75788780
26MP0005076_abnormal_cell_differentiation1.72994497
27MP0004233_abnormal_muscle_weight1.72019281
28MP0003942_abnormal_urinary_system1.69568540
29MP0003115_abnormal_respiratory_system1.68998157
30MP0004185_abnormal_adipocyte_glucose1.59895177
31MP0000733_abnormal_muscle_development1.58002917
32MP0003453_abnormal_keratinocyte_physiol1.57769543
33MP0010630_abnormal_cardiac_muscle1.57722921
34MP0002234_abnormal_pharynx_morphology1.57379941
35MP0002796_impaired_skin_barrier1.56765666
36MP0000534_abnormal_ureter_morphology1.56652014
37MP0000049_abnormal_middle_ear1.56496463
38MP0000749_muscle_degeneration1.56369877
39MP0008438_abnormal_cutaneous_collagen1.56098472
40MP0004264_abnormal_extraembryonic_tissu1.55937729
41MP0001348_abnormal_lacrimal_gland1.55257759
42MP0004087_abnormal_muscle_fiber1.55132977
43MP0009384_cardiac_valve_regurgitation1.53299788
44MP0002249_abnormal_larynx_morphology1.52928089
45MP0002060_abnormal_skin_morphology1.51203389
46MP0002972_abnormal_cardiac_muscle1.50022579
47MP0000428_abnormal_craniofacial_morphol1.49974680
48MP0005248_abnormal_Harderian_gland1.47905273
49MP0003646_muscle_fatigue1.46143217
50MP0002896_abnormal_bone_mineralization1.45154954
51MP0004215_abnormal_myocardial_fiber1.44892460
52MP0003279_aneurysm1.44752454
53MP0003935_abnormal_craniofacial_develop1.43049235
54MP0008789_abnormal_olfactory_epithelium1.42079889
55MP0000778_abnormal_nervous_system1.41881784
56MP0003119_abnormal_digestive_system1.40506820
57MP0003755_abnormal_palate_morphology1.39269058
58MP0003137_abnormal_impulse_conducting1.39170281
59MP0000003_abnormal_adipose_tissue1.37865764
60MP0005666_abnormal_adipose_tissue1.35147964
61MP0006138_congestive_heart_failure1.34899728
62MP0002116_abnormal_craniofacial_bone1.34256839
63MP0002089_abnormal_postnatal_growth/wei1.32928493
64MP0004858_abnormal_nervous_system1.29785851
65MP0005257_abnormal_intraocular_pressure1.29098472
66MP0003941_abnormal_skin_development1.28601450
67MP0005375_adipose_tissue_phenotype1.27710415
68MP0005023_abnormal_wound_healing1.26480509
69MP0005499_abnormal_olfactory_system1.25468617
70MP0005394_taste/olfaction_phenotype1.25468617
71MP0005620_abnormal_muscle_contractility1.25162828
72MP0004036_abnormal_muscle_relaxation1.24602840
73MP0005623_abnormal_meninges_morphology1.23292683
74MP0000579_abnormal_nail_morphology1.22877776
75MP0008775_abnormal_heart_ventricle1.21971529
76MP0002127_abnormal_cardiovascular_syste1.20485680
77MP0002932_abnormal_joint_morphology1.18159087
78MP0005330_cardiomyopathy1.17475875
79MP0005385_cardiovascular_system_phenoty1.17224739
80MP0001544_abnormal_cardiovascular_syste1.17224739
81MP0009250_abnormal_appendicular_skeleto1.17050033
82MP0010352_gastrointestinal_tract_polyps1.15406526
83MP0003123_paternal_imprinting1.14492058
84MP0003172_abnormal_lysosome_physiology1.14298115
85MP0009840_abnormal_foam_cell1.12701592
86MP0002233_abnormal_nose_morphology1.12250345
87MP0002108_abnormal_muscle_morphology1.11911358
88MP0002098_abnormal_vibrissa_morphology1.11728793
89MP0000762_abnormal_tongue_morphology1.11276196
90MP0005508_abnormal_skeleton_morphology1.10568052
91* MP0000266_abnormal_heart_morphology1.10297220
92MP0000747_muscle_weakness1.10049394
93MP0004197_abnormal_fetal_growth/weight/1.09398233
94MP0003567_abnormal_fetal_cardiomyocyte1.08604960
95MP0000516_abnormal_urinary_system1.08504479
96MP0005367_renal/urinary_system_phenotyp1.08504479
97MP0003566_abnormal_cell_adhesion1.08389198
98MP0008961_abnormal_basal_metabolism1.07675884
99MP0005369_muscle_phenotype1.07533632
100MP0002106_abnormal_muscle_physiology1.07101292
101MP0005501_abnormal_skin_physiology1.05805419
102MP0003984_embryonic_growth_retardation1.04822472
103MP0009278_abnormal_bone_marrow1.04711695
104MP0003300_gastrointestinal_ulcer1.03895238
105MP0000467_abnormal_esophagus_morphology1.02689126
106MP0001299_abnormal_eye_distance/1.02497286
107MP0003329_amyloid_beta_deposits1.02495859
108* MP0002925_abnormal_cardiovascular_devel1.02273964
109MP0002088_abnormal_embryonic_growth/wei1.02260401
110MP0005646_abnormal_pituitary_gland1.01310244
111MP0000678_abnormal_parathyroid_gland1.00840192
112MP0000759_abnormal_skeletal_muscle1.00499285
113MP0008260_abnormal_autophagy1.00340169
114MP0003937_abnormal_limbs/digits/tail_de1.00205181
115MP0004085_abnormal_heartbeat0.99879143
116MP0000432_abnormal_head_morphology0.98983724
117MP0002269_muscular_atrophy0.98727142
118MP0001346_abnormal_lacrimal_gland0.98644062
119MP0004145_abnormal_muscle_electrophysio0.98266677
120MP0000462_abnormal_digestive_system0.97561474
121MP0004859_abnormal_synaptic_plasticity0.96780708
122* MP0003861_abnormal_nervous_system0.96185108
123MP0009672_abnormal_birth_weight0.96038617
124MP0004272_abnormal_basement_membrane0.94866929
125MP0002697_abnormal_eye_size0.94701934
126MP0000767_abnormal_smooth_muscle0.94458377
127MP0001849_ear_inflammation0.94182345
128MP0004134_abnormal_chest_morphology0.94029679
129MP0001915_intracranial_hemorrhage0.94020991
130MP0001672_abnormal_embryogenesis/_devel0.91645801
131MP0005380_embryogenesis_phenotype0.91645801
132MP0006292_abnormal_olfactory_placode0.90812882
133MP0010368_abnormal_lymphatic_system0.90392405
134MP0005670_abnormal_white_adipose0.90160048
135MP0000750_abnormal_muscle_regeneration0.88009091
136MP0003191_abnormal_cellular_cholesterol0.87311550
137MP0001293_anophthalmia0.87150981
138MP0009703_decreased_birth_body0.85539638
139MP0008007_abnormal_cellular_replicative0.85283976
140MP0003634_abnormal_glial_cell0.84359882
141MP0000377_abnormal_hair_follicle0.80341160
142MP0005621_abnormal_cell_physiology0.78627614
143MP0000858_altered_metastatic_potential0.78522462
144MP0001216_abnormal_epidermal_layer0.78121875
145MP0009931_abnormal_skin_appearance0.77901642
146MP0001614_abnormal_blood_vessel0.76009539
147MP0004510_myositis0.75206042
148MP0004782_abnormal_surfactant_physiolog0.74475008
149MP0001730_embryonic_growth_arrest0.73197418
150MP0002254_reproductive_system_inflammat0.71946108
151MP0002113_abnormal_skeleton_development0.71214091
152MP0002086_abnormal_extraembryonic_tissu0.69397517
153MP0001243_abnormal_dermal_layer0.68788090
154* MP0002114_abnormal_axial_skeleton0.68700086
155MP0002092_abnormal_eye_morphology0.64666772
156MP0000627_abnormal_mammary_gland0.64559771

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.21486172
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21486172
3Shallow orbits (HP:0000586)3.17542185
4Obstructive sleep apnea (HP:0002870)3.08786640
5Renal duplication (HP:0000075)3.08321560
6Subaortic stenosis (HP:0001682)3.04088293
7Abnormality of the left ventricular outflow tract (HP:0011103)3.04088293
8Hepatoblastoma (HP:0002884)2.79543201
9Atrial fibrillation (HP:0005110)2.78205976
10Broad face (HP:0000283)2.78022858
11Ulnar bowing (HP:0003031)2.74611514
12Primary atrial arrhythmia (HP:0001692)2.62380046
13Hyperacusis (HP:0010780)2.62296155
14Fragile skin (HP:0001030)2.62266408
15Sudden death (HP:0001699)2.62043136
16Abnormality of the 4th metacarpal (HP:0010012)2.59242668
17Cervical subluxation (HP:0003308)2.57650656
18Ventricular tachycardia (HP:0004756)2.46211967
19Elfin facies (HP:0004428)2.45960926
20Asymmetry of the thorax (HP:0001555)2.45096531
21Supraventricular tachycardia (HP:0004755)2.44676811
22Thin bony cortex (HP:0002753)2.42556158
23Flat acetabular roof (HP:0003180)2.42535942
24Supraventricular arrhythmia (HP:0005115)2.42447891
25Arterial tortuosity (HP:0005116)2.39522596
26Vascular tortuosity (HP:0004948)2.39357014
27Disproportionate tall stature (HP:0001519)2.34608469
28Atrophic scars (HP:0001075)2.34413040
29Vertebral compression fractures (HP:0002953)2.30566652
30Protrusio acetabuli (HP:0003179)2.30460136
31Spinal rigidity (HP:0003306)2.29275058
32Blue sclerae (HP:0000592)2.27599111
33Aortic dissection (HP:0002647)2.26728862
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25954475
35Spinal cord lesions (HP:0100561)2.24371614
36Syringomyelia (HP:0003396)2.24371614
37Increased variability in muscle fiber diameter (HP:0003557)2.24138744
38Abnormality of the aortic arch (HP:0012303)2.23563362
39Renovascular hypertension (HP:0100817)2.21778525
40Mitral regurgitation (HP:0001653)2.20521357
41Aneurysm (HP:0002617)2.19546316
42Upper limb amyotrophy (HP:0009129)2.17793349
43Distal upper limb amyotrophy (HP:0007149)2.17793349
44Biconcave vertebral bodies (HP:0004586)2.15342640
45Lymphangioma (HP:0100764)2.15247920
46Distal lower limb amyotrophy (HP:0008944)2.15208409
47Astrocytoma (HP:0009592)2.14752488
48Abnormality of the astrocytes (HP:0100707)2.14752488
49Abnormality of the intervertebral disk (HP:0005108)2.14283689
50Wormian bones (HP:0002645)2.12285272
51Right ventricular cardiomyopathy (HP:0011663)2.12230585
52Bladder diverticulum (HP:0000015)2.12018828
53Abnormality of the fingertips (HP:0001211)2.11574632
54Urethral obstruction (HP:0000796)2.11498201
55Trigonocephaly (HP:0000243)2.11346541
56Increased nuchal translucency (HP:0010880)2.07979931
57Aortic aneurysm (HP:0004942)2.06442328
58Advanced eruption of teeth (HP:0006288)2.05939858
59Abnormality of the calf musculature (HP:0001430)2.05704758
60Ankle contracture (HP:0006466)2.05655134
61Broad metatarsal (HP:0001783)2.05276183
62Abnormality of the right ventricle (HP:0001707)2.04860753
63Deep venous thrombosis (HP:0002625)2.04469147
64Long eyelashes (HP:0000527)2.04391291
65Genu recurvatum (HP:0002816)2.03358498
66Distal lower limb muscle weakness (HP:0009053)2.02249084
67Thin ribs (HP:0000883)2.01341764
68Mitral valve prolapse (HP:0001634)2.00914276
69Flat cornea (HP:0007720)2.00311018
70Papillary thyroid carcinoma (HP:0002895)1.99848127
71Metaphyseal cupping (HP:0003021)1.93334255
72Abnormality of the nasal septum (HP:0000419)1.93176062
73Neoplasm of the adrenal cortex (HP:0100641)1.93092814
74Abnormality of dentin (HP:0010299)1.92840554
75Wrist flexion contracture (HP:0001239)1.92344311
76Dilatation of the ascending aorta (HP:0005111)1.91938748
77Premature rupture of membranes (HP:0001788)1.91931872
78Meningioma (HP:0002858)1.91767080
79Exercise-induced muscle cramps (HP:0003710)1.91606318
80Prolonged QT interval (HP:0001657)1.91277999
81Cupped ribs (HP:0000887)1.91092461
82Abnormality of skeletal muscle fiber size (HP:0012084)1.91000786
83Hyperextensible skin (HP:0000974)1.90976336
84Genetic anticipation (HP:0003743)1.90451702
85Mildly elevated creatine phosphokinase (HP:0008180)1.90316102
86Achilles tendon contracture (HP:0001771)1.87976461
87Bowel diverticulosis (HP:0005222)1.87236781
88Broad toe (HP:0001837)1.86938359
89Arnold-Chiari malformation (HP:0002308)1.86799563
90Joint laxity (HP:0001388)1.86519231
91Turricephaly (HP:0000262)1.86328378
92Bronchomalacia (HP:0002780)1.85826448
93Uterine leiomyosarcoma (HP:0002891)1.84518453
94Leiomyosarcoma (HP:0100243)1.84518453
95Short 5th finger (HP:0009237)1.83560938
96Glioma (HP:0009733)1.83406593
97Mesomelia (HP:0003027)1.82981031
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.82640781
99Broad thumb (HP:0011304)1.82023763
100Lipoatrophy (HP:0100578)1.80926659
101Deviation of the hallux (HP:0010051)1.80081840
102Vertebral arch anomaly (HP:0008438)1.79060703
103Back pain (HP:0003418)1.78491200
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.76187999
105Spina bifida occulta (HP:0003298)1.76078687
106Natal tooth (HP:0000695)1.75469253
107Patellar dislocation (HP:0002999)1.75403138
108Midline defect of the nose (HP:0004122)1.75266502
109Increased connective tissue (HP:0009025)1.75211891
110Hallux valgus (HP:0001822)1.75019596
111Wide anterior fontanel (HP:0000260)1.74990437
112Neonatal short-limb short stature (HP:0008921)1.74234246
113Ankyloglossia (HP:0010296)1.74065456
114Abnormality of the pubic bones (HP:0003172)1.73787511
115Cerebral inclusion bodies (HP:0100314)1.73346502
116Broad palm (HP:0001169)1.73053464
117Type 1 muscle fiber predominance (HP:0003803)1.72968792
118Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.72888251
119Skull defect (HP:0001362)1.72755393
120Bundle branch block (HP:0011710)1.71649200
121Soft skin (HP:0000977)1.71344597
122Pointed chin (HP:0000307)1.70848964
123Deep philtrum (HP:0002002)1.70513826
124Abnormality of chromosome segregation (HP:0002916)1.70282982
125Hypoplastic ischia (HP:0003175)1.70117313
126Abnormality of the Achilles tendon (HP:0005109)1.69700962
127Lower limb amyotrophy (HP:0007210)1.69693111
128Ventricular arrhythmia (HP:0004308)1.69052966
129Macroorchidism (HP:0000053)1.68838388
130Narrow nasal bridge (HP:0000446)1.68510849
131Hypoplastic labia majora (HP:0000059)1.68503864
132Abnormality of the calcaneus (HP:0008364)1.67662154
133Hemorrhage of the eye (HP:0011885)1.67588989
134Hyperparathyroidism (HP:0000843)1.65863742
135Morphological abnormality of the middle ear (HP:0008609)1.65654971
136Exostoses (HP:0100777)1.65450584
137Cerebral aneurysm (HP:0004944)1.64625694
138Overriding aorta (HP:0002623)1.64555324
139Coxa vara (HP:0002812)1.63887361
140Precocious puberty (HP:0000826)1.63783666
141Dislocated radial head (HP:0003083)1.63343407
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.62984514
143Hamartoma of the eye (HP:0010568)1.62973350
144Venous abnormality (HP:0002624)1.62588748
145Narrow palate (HP:0000189)1.62483015
146Long palpebral fissure (HP:0000637)1.62077705
147Abnormality of the acetabulum (HP:0003170)1.61951429
148Sparse lateral eyebrow (HP:0005338)1.61930943
149Broad phalanges of the hand (HP:0009768)1.61451051
150Neurofibrillary tangles (HP:0002185)1.61276698
151Broad finger (HP:0001500)1.61251509
152Hand muscle atrophy (HP:0009130)1.61115717
153Round ear (HP:0100830)1.61086764
154Broad long bones (HP:0005622)1.61013217
155Hypoventilation (HP:0002791)1.60568318
156Nuclear cataract (HP:0100018)1.60454239
157Neoplasm of the heart (HP:0100544)1.59877174
158Ectopic kidney (HP:0000086)1.59230089
159Benign neoplasm of the central nervous system (HP:0100835)1.59054809
160Hamartoma (HP:0010566)1.58302305
161Premature skin wrinkling (HP:0100678)1.58133369
162Hammertoe (HP:0001765)1.57939785
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57936752
164Broad phalanx (HP:0006009)1.57693311
165Germ cell neoplasia (HP:0100728)1.57357663
166Elbow flexion contracture (HP:0002987)1.57327128
167Hypercortisolism (HP:0001578)1.57111760
168Abnormality of the radial head (HP:0003995)1.57094737
169Broad hallux (HP:0010055)1.56080817
170Overgrowth (HP:0001548)1.56027728
171Abnormality of the labia majora (HP:0012881)1.56007788
172Enlarged penis (HP:0000040)1.55875249
173Insomnia (HP:0100785)1.55751523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.25879328
2LATS13.45027737
3CDK123.08975736
4SIK32.99895343
5EPHB22.74712757
6SMG12.71803458
7FGFR42.43924173
8TRIB32.40794429
9STK38L2.17756744
10LMTK22.14524263
11DMPK2.10669182
12ERBB32.07202007
13MAP3K102.02579052
14PKN21.94190810
15SIK11.91893607
16EPHA21.89942694
17SGK21.83949489
18SGK31.69704634
19IRAK31.67368650
20PRKD31.65836071
21TTN1.65495311
22PDGFRA1.60614825
23AKT31.58514306
24CDC42BPA1.55505330
25MARK11.53040037
26LATS21.51888269
27NTRK11.45835981
28KSR11.44604510
29STK241.42711893
30EPHB11.36648678
31ZAK1.34749364
32OBSCN1.33851175
33RIPK11.26555374
34DDR21.22823781
35PAK41.21244046
36NUAK11.20516697
37TESK11.20222036
38SIK21.18658102
39FGFR31.18456738
40ICK1.17240949
41SGK2231.12420744
42SGK4941.12420744
43KSR21.08659247
44PHKG21.07369397
45PHKG11.07369397
46MTOR1.07148434
47CAMK1G1.06382619
48EEF2K1.01175868
49MST1R1.01129333
50MAP3K60.97004031
51ROCK10.95398826
52PRKCH0.94163003
53STK30.93397623
54MET0.89966614
55BRD40.89467956
56CAMK1D0.89021636
57PAK20.88993791
58RPS6KA20.87878062
59FGFR10.87036348
60RET0.86387393
61STK380.85310962
62PIK3CA0.85266207
63PRKAA10.85099357
64NEK10.81833380
65CHUK0.80604011
66ERBB20.78263039
67NEK90.76826667
68PAK60.75200295
69PTK60.74445138
70ERN10.74340639
71NTRK20.73673084
72MAPKAPK30.72819951
73TAOK20.71756444
74PAK30.71741557
75MAP3K30.71081622
76CAMK40.70321727
77PLK20.69731517
78HIPK20.68658900
79PDPK10.67339138
80MAP3K130.65275002
81BRSK10.64581541
82CDK70.63669490
83MINK10.62638683
84TRPM70.62354748
85MAP3K70.62318118
86FGFR20.61564214
87CAMKK10.61246942
88MAP2K30.59215047
89MAP3K40.57865405
90YES10.56437594
91RPS6KB10.55435047
92PINK10.55297786
93AKT20.55295449
94EPHA30.53656407
95CASK0.53477544
96MAPK130.52778945
97RPS6KB20.52380017
98MYLK0.52099794
99INSRR0.51832362
100MAP2K20.50638863
101SGK10.50092811
102DYRK1B0.50001897
103RPS6KL10.49358855
104RPS6KC10.49358855
105AKT10.49128896
106MAP3K10.48774178
107MAPK80.48077105
108TAOK10.47858179
109MAPK110.47069111
110PDGFRB0.46840007
111CDK80.46170423
112BMX0.45948148
113PRKD20.45596321
114UHMK10.44118511
115TYRO30.43956862
116RPS6KA10.43790518
117ROCK20.43652900
118NEK60.43042732
119LRRK20.42849254
120PTK20.42201942
121DYRK20.41779393
122GSK3B0.41725085
123MAPKAPK20.41557621
124CDK60.40552509
125CDK90.40454286
126MAPK100.38633168
127MAPK70.38122271
128MAPK140.37672317
129ALK0.37444980
130MAP3K80.36863090
131RPS6KA60.36717556
132PRKD10.36457180
133CDK40.36369890
134MAP2K10.35600143
135MAP2K70.35335018
136CLK10.35283269
137ILK0.34925943
138ATR0.34632517
139MOS0.33721234
140MARK20.33539601
141MAP3K20.33380285
142MAP3K90.33280821
143IRAK20.30673304
144MELK0.29649523
145WNK10.29014605
146CDK150.28386746
147CDK11A0.28324991

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.43126367
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.33465493
3* Basal cell carcinoma_Homo sapiens_hsa052172.14569238
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13634042
5Endometrial cancer_Homo sapiens_hsa052132.08153487
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.99055188
7* Notch signaling pathway_Homo sapiens_hsa043301.86399035
8Adherens junction_Homo sapiens_hsa045201.84364427
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81717164
10* Hippo signaling pathway_Homo sapiens_hsa043901.79179775
11Hedgehog signaling pathway_Homo sapiens_hsa043401.78329955
12Other glycan degradation_Homo sapiens_hsa005111.75856007
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.68909810
14Viral myocarditis_Homo sapiens_hsa054161.63938903
15Lysine degradation_Homo sapiens_hsa003101.61906713
16VEGF signaling pathway_Homo sapiens_hsa043701.56113523
17Colorectal cancer_Homo sapiens_hsa052101.47763979
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47440609
19Prion diseases_Homo sapiens_hsa050201.45059003
20Chronic myeloid leukemia_Homo sapiens_hsa052201.44192088
21Axon guidance_Homo sapiens_hsa043601.42683275
22Proteoglycans in cancer_Homo sapiens_hsa052051.42202909
23Focal adhesion_Homo sapiens_hsa045101.41809405
24Type II diabetes mellitus_Homo sapiens_hsa049301.39859377
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37891977
26mTOR signaling pathway_Homo sapiens_hsa041501.36083292
27MicroRNAs in cancer_Homo sapiens_hsa052061.35259838
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33234482
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33034909
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.29307420
31* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27974841
32* Wnt signaling pathway_Homo sapiens_hsa043101.21628702
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21026102
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20158397
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.15757489
36ErbB signaling pathway_Homo sapiens_hsa040121.15410288
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.14902061
38Glioma_Homo sapiens_hsa052141.13286157
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10408402
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.06695360
41ECM-receptor interaction_Homo sapiens_hsa045121.05937608
42Tight junction_Homo sapiens_hsa045301.05122056
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.04384571
44Non-small cell lung cancer_Homo sapiens_hsa052231.04293631
45Insulin signaling pathway_Homo sapiens_hsa049101.01193669
46Insulin resistance_Homo sapiens_hsa049311.01057855
47Pancreatic cancer_Homo sapiens_hsa052121.00912516
48mRNA surveillance pathway_Homo sapiens_hsa030151.00240993
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98722091
50Small cell lung cancer_Homo sapiens_hsa052220.98312627
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97926680
52Circadian entrainment_Homo sapiens_hsa047130.94918783
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93065163
54Insulin secretion_Homo sapiens_hsa049110.92967996
55Olfactory transduction_Homo sapiens_hsa047400.92470799
56Circadian rhythm_Homo sapiens_hsa047100.92414613
57* Pathways in cancer_Homo sapiens_hsa052000.91861706
58Melanoma_Homo sapiens_hsa052180.91110975
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90965552
60TGF-beta signaling pathway_Homo sapiens_hsa043500.90830532
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90112550
62Fructose and mannose metabolism_Homo sapiens_hsa000510.88396480
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88279972
64FoxO signaling pathway_Homo sapiens_hsa040680.86908860
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85654487
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85431525
67Prolactin signaling pathway_Homo sapiens_hsa049170.85038068
68* Melanogenesis_Homo sapiens_hsa049160.84733858
69* HTLV-I infection_Homo sapiens_hsa051660.84641352
70Hepatitis C_Homo sapiens_hsa051600.84376393
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83999974
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83871205
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.83281033
74Inositol phosphate metabolism_Homo sapiens_hsa005620.80313666
75Bladder cancer_Homo sapiens_hsa052190.79755314
76Prostate cancer_Homo sapiens_hsa052150.79345100
77AMPK signaling pathway_Homo sapiens_hsa041520.79120933
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.78650802
79Rap1 signaling pathway_Homo sapiens_hsa040150.77445179
80cAMP signaling pathway_Homo sapiens_hsa040240.77029240
81Endocytosis_Homo sapiens_hsa041440.76145656
82Protein digestion and absorption_Homo sapiens_hsa049740.75348604
83Cholinergic synapse_Homo sapiens_hsa047250.75127861
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74977284
85HIF-1 signaling pathway_Homo sapiens_hsa040660.74876413
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74051380
87Estrogen signaling pathway_Homo sapiens_hsa049150.73666124
88Cell cycle_Homo sapiens_hsa041100.73112329
89Renal cell carcinoma_Homo sapiens_hsa052110.73001294
90Gap junction_Homo sapiens_hsa045400.71843393
91MAPK signaling pathway_Homo sapiens_hsa040100.71367407
92Acute myeloid leukemia_Homo sapiens_hsa052210.71240341
93Oxytocin signaling pathway_Homo sapiens_hsa049210.70987481
94Vibrio cholerae infection_Homo sapiens_hsa051100.69720047
95Taste transduction_Homo sapiens_hsa047420.68956232
96Pentose phosphate pathway_Homo sapiens_hsa000300.68539786
97B cell receptor signaling pathway_Homo sapiens_hsa046620.68459569
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.67092035
99Dorso-ventral axis formation_Homo sapiens_hsa043200.66186264
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65451330
101Glucagon signaling pathway_Homo sapiens_hsa049220.65065276
102TNF signaling pathway_Homo sapiens_hsa046680.64836945
103Amoebiasis_Homo sapiens_hsa051460.64293642
104Thyroid hormone synthesis_Homo sapiens_hsa049180.63512364
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62062454
106Lysosome_Homo sapiens_hsa041420.61384515
107Choline metabolism in cancer_Homo sapiens_hsa052310.60494466
108Synaptic vesicle cycle_Homo sapiens_hsa047210.60481322
109Dopaminergic synapse_Homo sapiens_hsa047280.59940508
110Galactose metabolism_Homo sapiens_hsa000520.59545727
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58093483
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57790842
113Toxoplasmosis_Homo sapiens_hsa051450.57227752
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55799744
115GnRH signaling pathway_Homo sapiens_hsa049120.55596200
116Nicotine addiction_Homo sapiens_hsa050330.53320775
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51493131
118Biosynthesis of amino acids_Homo sapiens_hsa012300.51469673
119Morphine addiction_Homo sapiens_hsa050320.51423177
120Thyroid cancer_Homo sapiens_hsa052160.51157475
121Calcium signaling pathway_Homo sapiens_hsa040200.50167122
122Long-term potentiation_Homo sapiens_hsa047200.50118939
123Hepatitis B_Homo sapiens_hsa051610.48164942
124Glutamatergic synapse_Homo sapiens_hsa047240.47192045
125GABAergic synapse_Homo sapiens_hsa047270.46554628
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46427466

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