DXO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of DNA-templated transcription, elongation (GO:0032785)5.36076632
2GDP-mannose metabolic process (GO:0019673)5.21965084
3DNA deamination (GO:0045006)5.13953937
4negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.05489206
5DNA strand elongation involved in DNA replication (GO:0006271)4.68618178
6ribosomal small subunit assembly (GO:0000028)4.68190720
7telomere maintenance via semi-conservative replication (GO:0032201)4.66486270
8DNA strand elongation (GO:0022616)4.41973433
9rRNA modification (GO:0000154)4.23916798
10maturation of SSU-rRNA (GO:0030490)4.18001798
11peptidyl-arginine omega-N-methylation (GO:0035247)4.13784867
12negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.11628892
13DNA replication initiation (GO:0006270)4.06806601
14rRNA methylation (GO:0031167)4.05276097
15metallo-sulfur cluster assembly (GO:0031163)4.00779406
16iron-sulfur cluster assembly (GO:0016226)4.00779406
17telomere maintenance via recombination (GO:0000722)3.94742099
18purine deoxyribonucleotide catabolic process (GO:0009155)3.87998919
19UV protection (GO:0009650)3.80765867
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.77785710
21viral transcription (GO:0019083)3.75824802
22folic acid-containing compound biosynthetic process (GO:0009396)3.74985451
23nucleobase biosynthetic process (GO:0046112)3.67380633
24base-excision repair, AP site formation (GO:0006285)3.66477862
25translational termination (GO:0006415)3.63272735
26spliceosomal tri-snRNP complex assembly (GO:0000244)3.63016906
27ribosomal large subunit biogenesis (GO:0042273)3.62480602
28DNA unwinding involved in DNA replication (GO:0006268)3.62440743
29mitotic recombination (GO:0006312)3.56725320
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54876576
31negative regulation of erythrocyte differentiation (GO:0045647)3.48974442
32regulation of telomere maintenance via telomerase (GO:0032210)3.46823434
33telomere maintenance via telomere lengthening (GO:0010833)3.45795400
34protein retention in ER lumen (GO:0006621)3.44586302
35pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.43044747
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.40856925
37translational elongation (GO:0006414)3.38046855
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36003274
39purine nucleotide salvage (GO:0032261)3.32889367
40purine nucleobase biosynthetic process (GO:0009113)3.32858139
41negative regulation of B cell apoptotic process (GO:0002903)3.32385402
42formation of translation preinitiation complex (GO:0001731)3.29261283
43deoxyribose phosphate catabolic process (GO:0046386)3.28905984
44mature B cell differentiation involved in immune response (GO:0002313)3.27928441
45DNA replication checkpoint (GO:0000076)3.27744103
46pteridine-containing compound biosynthetic process (GO:0042559)3.24997403
47ribosomal small subunit biogenesis (GO:0042274)3.24241558
48pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.22639942
49protein targeting to ER (GO:0045047)3.22174309
50cotranslational protein targeting to membrane (GO:0006613)3.22071374
51peptidyl-arginine methylation (GO:0018216)3.15480852
52peptidyl-arginine N-methylation (GO:0035246)3.15480852
53nucleoside salvage (GO:0043174)3.14532258
54phosphatidylglycerol biosynthetic process (GO:0006655)3.14095650
55misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.12226580
56protein insertion into membrane (GO:0051205)3.12102553
57modulation by virus of host process (GO:0019054)3.11890146
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10819227
59glycine metabolic process (GO:0006544)3.07666191
60folic acid metabolic process (GO:0046655)3.07203390
61proline biosynthetic process (GO:0006561)3.06701992
62pyrimidine-containing compound salvage (GO:0008655)3.06155709
63pyrimidine nucleoside salvage (GO:0043097)3.06155709
64pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.04648530
65UMP metabolic process (GO:0046049)3.04648530
66pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.04648530
67UMP biosynthetic process (GO:0006222)3.04648530
68translational initiation (GO:0006413)3.04493689
69pentose metabolic process (GO:0019321)3.03870434
70protein localization to endoplasmic reticulum (GO:0070972)3.03297546
71response to misfolded protein (GO:0051788)3.02740872
72response to muramyl dipeptide (GO:0032495)2.99348829
73establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99025651
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98175774
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96796564
76protein deneddylation (GO:0000338)2.96698969
77peptidyl-histidine modification (GO:0018202)2.96666797
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94937938
79ribonucleoprotein complex biogenesis (GO:0022613)2.92555479
80Golgi transport vesicle coating (GO:0048200)2.92139633
81COPI coating of Golgi vesicle (GO:0048205)2.92139633
82mannose metabolic process (GO:0006013)2.91565793
83histone arginine methylation (GO:0034969)2.91028322
84regulation of translational fidelity (GO:0006450)2.90873472
85RNA methylation (GO:0001510)2.90587031
86cullin deneddylation (GO:0010388)2.89432567
87regulation of cytokine production involved in inflammatory response (GO:1900015)2.88871836
88viral life cycle (GO:0019058)2.85669094
89histone H4 deacetylation (GO:0070933)2.84622801
90negative regulation of RNA splicing (GO:0033119)2.83081835
91spliceosomal snRNP assembly (GO:0000387)2.80544456
92protein localization to kinetochore (GO:0034501)2.79912456
93regulation of hydrogen peroxide metabolic process (GO:0010310)2.79291921
94tRNA modification (GO:0006400)2.77307327
95tetrahydrofolate metabolic process (GO:0046653)2.77016678
96cellular protein complex disassembly (GO:0043624)2.76216723
97mitotic nuclear envelope disassembly (GO:0007077)2.76178336
98protein-DNA complex disassembly (GO:0032986)2.75249546
99nucleosome disassembly (GO:0006337)2.75249546
100maintenance of protein localization in organelle (GO:0072595)2.73482688
101nucleotide salvage (GO:0043173)2.73038373
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71696260
103negative regulation of Notch signaling pathway (GO:0045746)2.71619638
104peptidyl-glutamic acid carboxylation (GO:0017187)2.71361358
105protein carboxylation (GO:0018214)2.71361358
106histone H3 deacetylation (GO:0070932)2.70364764
107serine family amino acid biosynthetic process (GO:0009070)2.70312215
108purine deoxyribonucleotide metabolic process (GO:0009151)2.68440072
109tRNA methylation (GO:0030488)2.67782176
110regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67315376
111dosage compensation (GO:0007549)2.67145825
112ribosome biogenesis (GO:0042254)2.65710696
1132-deoxyribonucleotide metabolic process (GO:0009394)2.65058165
114negative regulation of cell size (GO:0045792)2.64838359
115mitotic metaphase plate congression (GO:0007080)2.64566894
116negative regulation of gene silencing (GO:0060969)2.62346729
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.62101974
118translation (GO:0006412)2.60547832
119guanosine-containing compound biosynthetic process (GO:1901070)2.60091924
120negative regulation of mRNA processing (GO:0050686)2.58965346
121mitochondrial RNA metabolic process (GO:0000959)2.58810873
122IMP biosynthetic process (GO:0006188)2.57879759
123intracellular estrogen receptor signaling pathway (GO:0030520)2.57423088
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.57149905
125pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57138867
126fusion of sperm to egg plasma membrane (GO:0007342)2.56456070
127regulation of monocyte differentiation (GO:0045655)2.56373978
128spliceosomal complex assembly (GO:0000245)2.55352048
129protein complex disassembly (GO:0043241)2.55078768
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54752598
131proteasome assembly (GO:0043248)2.54249984
132grooming behavior (GO:0007625)2.53339057
133pyrimidine nucleotide catabolic process (GO:0006244)2.53102534
134positive regulation of granulocyte differentiation (GO:0030854)2.52609222
135rRNA processing (GO:0006364)2.51793943
136pseudouridine synthesis (GO:0001522)2.51590082
137positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.50906700
138GMP metabolic process (GO:0046037)2.50871473
139protein localization to chromosome, centromeric region (GO:0071459)2.50709910
140transcription-coupled nucleotide-excision repair (GO:0006283)2.50642680
141retinoic acid receptor signaling pathway (GO:0048384)2.49131049
142proline metabolic process (GO:0006560)2.48546310
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.48521795
144establishment of integrated proviral latency (GO:0075713)2.48303581
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48264229
146membrane disassembly (GO:0030397)2.48165707
147nuclear envelope disassembly (GO:0051081)2.48165707
148telomere maintenance (GO:0000723)2.47854911
149telomere organization (GO:0032200)2.47733465
150mature B cell differentiation (GO:0002335)2.46885428
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46880042
152one-carbon metabolic process (GO:0006730)2.46647310
153rRNA metabolic process (GO:0016072)2.46363275
154metaphase plate congression (GO:0051310)2.45554148
155DNA replication-dependent nucleosome assembly (GO:0006335)2.45007493
156DNA replication-dependent nucleosome organization (GO:0034723)2.45007493
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44814508
158mitochondrial DNA metabolic process (GO:0032042)2.44225808
159base-excision repair (GO:0006284)2.44126258
160translesion synthesis (GO:0019985)2.43144377
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42781160
162protein maturation by protein folding (GO:0022417)2.42401282
163erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.41963231
164L-phenylalanine metabolic process (GO:0006558)2.41963231
165histone H2A acetylation (GO:0043968)2.41410309
166deoxyribonucleotide catabolic process (GO:0009264)2.40962590
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.40921674
168deoxyribose phosphate metabolic process (GO:0019692)2.40830674
1692-deoxyribonucleotide biosynthetic process (GO:0009265)2.40135501
170deoxyribose phosphate biosynthetic process (GO:0046385)2.40135501
171pteridine-containing compound metabolic process (GO:0042558)2.39947901
172macromolecular complex disassembly (GO:0032984)2.39912823
173L-serine metabolic process (GO:0006563)2.39644464
174mannosylation (GO:0097502)2.39208250
175microtubule severing (GO:0051013)2.39090261
176purinergic nucleotide receptor signaling pathway (GO:0035590)2.37875764
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37619624
178cellular metabolic compound salvage (GO:0043094)2.36752458
179positive regulation of protein kinase C signaling (GO:0090037)2.35913410
180RNA modification (GO:0009451)2.35566552
181ubiquinone metabolic process (GO:0006743)2.34930622
182NIK/NF-kappaB signaling (GO:0038061)2.33850983
183positive regulation of megakaryocyte differentiation (GO:0045654)2.33767583
184regulation of chromatin binding (GO:0035561)2.32914805
185erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32773694
186L-phenylalanine catabolic process (GO:0006559)2.32773694
187response to gravity (GO:0009629)2.32692855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44692335
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85879904
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.64225977
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.89152212
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62934804
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61848463
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57023894
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50292519
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46017596
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.41781603
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39149818
12LXR_22292898_ChIP-Seq_THP-1_Human2.38224397
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33362726
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29584943
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.28773130
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28085205
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.27095168
18XRN2_22483619_ChIP-Seq_HELA_Human2.25907382
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.25123767
20P68_20966046_ChIP-Seq_HELA_Human2.16139654
21MYC_22102868_ChIP-Seq_BL_Human2.08395024
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06582760
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04448846
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94726543
25VDR_23849224_ChIP-Seq_CD4+_Human1.94190284
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93857138
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92274753
28BCL6_27268052_Chip-Seq_Bcells_Human1.90326727
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89912021
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85052702
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84135729
32FOXP3_21729870_ChIP-Seq_TREG_Human1.82574948
33GABP_19822575_ChIP-Seq_HepG2_Human1.79549386
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79177480
35DCP1A_22483619_ChIP-Seq_HELA_Human1.79088167
36AR_21909140_ChIP-Seq_LNCAP_Human1.72922854
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72385404
38CIITA_25753668_ChIP-Seq_RAJI_Human1.70230566
39BCOR_27268052_Chip-Seq_Bcells_Human1.70142310
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69342406
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.65034616
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.60680936
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57057446
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56263854
45VDR_21846776_ChIP-Seq_THP-1_Human1.56198858
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.56126847
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54032921
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.53575939
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53122092
50PHF8_20622854_ChIP-Seq_HELA_Human1.51627809
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.51448015
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51116417
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.50778154
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50248370
55KDM2B_26808549_Chip-Seq_DND41_Human1.49517217
56E2F1_20622854_ChIP-Seq_HELA_Human1.48717168
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.48692925
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48471715
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48054092
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47751642
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47235170
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45512277
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44392809
64TTF2_22483619_ChIP-Seq_HELA_Human1.43907172
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43642398
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43358211
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.43352150
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40599479
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40300167
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.39467012
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38965864
72RACK7_27058665_Chip-Seq_MCF-7_Human1.38758073
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.38445748
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.38302523
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36783522
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36064414
77VDR_24763502_ChIP-Seq_THP-1_Human1.35653688
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34990977
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34290508
80TCF7_22412390_ChIP-Seq_EML_Mouse1.34249509
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34095282
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33442223
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33339369
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32711490
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32614983
86RARB_24833708_ChIP-Seq_LIVER_Mouse1.32015632
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31697986
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31359409
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30528880
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30254208
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30077139
92SMC4_20622854_ChIP-Seq_HELA_Human1.29634887
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29559538
94RARA_24833708_ChIP-Seq_LIVER_Mouse1.27273040
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27054073
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26859749
97NCOR1_26117541_ChIP-Seq_K562_Human1.26573467
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26419699
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.24514418
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23876804
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23766674
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23760590
103GATA1_22025678_ChIP-Seq_K562_Human1.22527197
104CTCF_21964334_Chip-Seq_Bcells_Human1.21365684
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20919250
106KDM5A_27292631_Chip-Seq_BREAST_Human1.20840794
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20468716
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19394761
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18783453
110ETS1_21867929_ChIP-Seq_TH2_Mouse1.17230119
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16782245
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16721147
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16543432
114ZNF263_19887448_ChIP-Seq_K562_Human1.15956391
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15167435
116CREB1_26743006_Chip-Seq_LNCaP_Human1.14631916
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14272236
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13996398
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13936840
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13858293
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13579344
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13376913
123RUNX1_22412390_ChIP-Seq_EML_Mouse1.13255632
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13248332
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.11996675
126CTCF_27219007_Chip-Seq_Bcells_Human1.10357120
127CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09977844
128CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09255215
129RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09062186
130TP53_22127205_ChIP-Seq_IMR90_Human1.07911895
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02362975
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00996276
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99614137
134MAF_26560356_Chip-Seq_TH2_Human0.99251862
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97293474
136MAF_26560356_Chip-Seq_TH1_Human0.97252832
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96999163
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96983763
139SPI1_23547873_ChIP-Seq_NB4_Human0.96467749
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96166920
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95453394
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95155425
143UTX_26944678_Chip-Seq_JUKART_Human0.93394938
144SCL_19346495_ChIP-Seq_HPC-7_Human0.91707204
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89887539
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.89465110
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88881777
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88193965
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84872424
150MYB_26560356_Chip-Seq_TH2_Human0.84374672
151TFEB_21752829_ChIP-Seq_HELA_Human0.84290763
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.83817130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.87753995
2MP0005058_abnormal_lysosome_morphology3.18739707
3MP0003111_abnormal_nucleus_morphology3.17623370
4MP0002139_abnormal_hepatobiliary_system3.00359633
5MP0004957_abnormal_blastocyst_morpholog2.80831346
6MP0010094_abnormal_chromosome_stability2.77994439
7MP0005360_urolithiasis2.75039994
8MP0003077_abnormal_cell_cycle2.70411671
9MP0003806_abnormal_nucleotide_metabolis2.69234180
10MP0008260_abnormal_autophagy2.62631001
11MP0005410_abnormal_fertilization2.62080821
12MP0002396_abnormal_hematopoietic_system2.54263901
13MP0008058_abnormal_DNA_repair2.52712083
14MP0008057_abnormal_DNA_replication2.50272494
15MP0005365_abnormal_bile_salt2.43784270
16MP0000490_abnormal_crypts_of1.93153701
17MP0005085_abnormal_gallbladder_physiolo1.90999042
18MP0005451_abnormal_body_composition1.86660212
19MP0000685_abnormal_immune_system1.81434961
20MP0010352_gastrointestinal_tract_polyps1.80982493
21MP0008007_abnormal_cellular_replicative1.79939632
22MP0000003_abnormal_adipose_tissue1.79161402
23MP0005397_hematopoietic_system_phenotyp1.78484923
24MP0001545_abnormal_hematopoietic_system1.78484923
25MP0001188_hyperpigmentation1.73302246
26MP0002822_catalepsy1.68645050
27MP0003656_abnormal_erythrocyte_physiolo1.67618347
28MP0002653_abnormal_ependyma_morphology1.67344542
29MP0001986_abnormal_taste_sensitivity1.64945143
30MP0008932_abnormal_embryonic_tissue1.62045347
31MP0006035_abnormal_mitochondrial_morpho1.57273447
32MP0009840_abnormal_foam_cell1.57105324
33MP0005646_abnormal_pituitary_gland1.56715720
34MP0009379_abnormal_foot_pigmentation1.55949658
35MP0003186_abnormal_redox_activity1.55455713
36MP0001730_embryonic_growth_arrest1.53757823
37MP0002638_abnormal_pupillary_reflex1.53004264
38MP0001873_stomach_inflammation1.52616531
39MP0003763_abnormal_thymus_physiology1.51494076
40MP0001666_abnormal_nutrient_absorption1.46773250
41MP0005220_abnormal_exocrine_pancreas1.44662681
42MP0005670_abnormal_white_adipose1.43936523
43MP0000350_abnormal_cell_proliferation1.43560838
44MP0002132_abnormal_respiratory_system1.43192418
45MP0001968_abnormal_touch/_nociception1.42241664
46MP0003786_premature_aging1.40233142
47MP0001661_extended_life_span1.38941596
48MP0003191_abnormal_cellular_cholesterol1.37034899
49MP0003303_peritoneal_inflammation1.34377158
50MP0002398_abnormal_bone_marrow1.31285685
51MP0005171_absent_coat_pigmentation1.29170313
52MP0004808_abnormal_hematopoietic_stem1.28794992
53MP0005000_abnormal_immune_tolerance1.28502514
54MP0002019_abnormal_tumor_incidence1.27504251
55MP0004233_abnormal_muscle_weight1.26741659
56MP0002138_abnormal_hepatobiliary_system1.26363246
57MP0000703_abnormal_thymus_morphology1.25721430
58MP0002722_abnormal_immune_system1.25252756
59MP0005075_abnormal_melanosome_morpholog1.23724170
60MP0003172_abnormal_lysosome_physiology1.22883300
61MP0009333_abnormal_splenocyte_physiolog1.21362751
62MP0000689_abnormal_spleen_morphology1.20240157
63MP0000313_abnormal_cell_death1.18858252
64MP0010030_abnormal_orbit_morphology1.17830295
65MP0003119_abnormal_digestive_system1.17768917
66MP0001502_abnormal_circadian_rhythm1.17683120
67MP0005423_abnormal_somatic_nervous1.17142142
68MP0009278_abnormal_bone_marrow1.14817704
69MP0000609_abnormal_liver_physiology1.14186893
70MP0005083_abnormal_biliary_tract1.11103098
71MP0003698_abnormal_male_reproductive1.10775167
72MP0002429_abnormal_blood_cell1.07996663
73MP0008995_early_reproductive_senescence1.07560825
74MP0002089_abnormal_postnatal_growth/wei1.06849872
75MP0002080_prenatal_lethality1.05962966
76MP0001800_abnormal_humoral_immune1.05924432
77MP0001764_abnormal_homeostasis1.05821014
78MP0006036_abnormal_mitochondrial_physio1.05352028
79MP0008875_abnormal_xenobiotic_pharmacok1.05203457
80MP0004133_heterotaxia1.04441534
81MP0002086_abnormal_extraembryonic_tissu1.04361739
82MP0005375_adipose_tissue_phenotype1.02681520
83MP0000598_abnormal_liver_morphology1.02583453
84MP0002249_abnormal_larynx_morphology1.01930818
85MP0001929_abnormal_gametogenesis1.01409223
86MP0000013_abnormal_adipose_tissue1.00634224
87MP0003868_abnormal_feces_composition1.00416510
88MP0001697_abnormal_embryo_size1.00365576
89MP0003252_abnormal_bile_duct1.00046282
90MP0000678_abnormal_parathyroid_gland0.99470271
91MP0002419_abnormal_innate_immunity0.99430049
92MP0005332_abnormal_amino_acid0.99422978
93MP0001727_abnormal_embryo_implantation0.99127798
94MP0000716_abnormal_immune_system0.98689171
95MP0005636_abnormal_mineral_homeostasis0.98572257
96MP0005319_abnormal_enzyme/_coenzyme0.98346930
97MP0000465_gastrointestinal_hemorrhage0.98129580
98MP0001293_anophthalmia0.97920113
99MP0005377_hearing/vestibular/ear_phenot0.97044364
100MP0003878_abnormal_ear_physiology0.97044364
101MP0000015_abnormal_ear_pigmentation0.96686451
102MP0009643_abnormal_urine_homeostasis0.95539216
103MP0004947_skin_inflammation0.94583042
104MP0010329_abnormal_lipoprotein_level0.92668341
105MP0001672_abnormal_embryogenesis/_devel0.90284524
106MP0005380_embryogenesis_phenotype0.90284524
107MP0004147_increased_porphyrin_level0.90079000
108MP0002970_abnormal_white_adipose0.89468462
109MP0005174_abnormal_tail_pigmentation0.89178786
110MP0003436_decreased_susceptibility_to0.88782467
111MP0002210_abnormal_sex_determination0.88732440
112MP0005645_abnormal_hypothalamus_physiol0.88438154
113MP0005023_abnormal_wound_healing0.87058814
114MP0001835_abnormal_antigen_presentation0.86837226
115MP0001348_abnormal_lacrimal_gland0.85802067
116MP0000358_abnormal_cell_content/0.85084251
117MP0000681_abnormal_thyroid_gland0.84728444
118MP0005025_abnormal_response_to0.84459223
119MP0002723_abnormal_immune_serum0.83749792
120MP0001919_abnormal_reproductive_system0.83486005
121MP0001845_abnormal_inflammatory_respons0.82609620
122MP0001243_abnormal_dermal_layer0.82365065
123MP0001853_heart_inflammation0.82087239
124MP0001145_abnormal_male_reproductive0.81913615
125MP0002405_respiratory_system_inflammati0.81687461
126MP0008469_abnormal_protein_level0.80998698
127MP0009672_abnormal_birth_weight0.80879622
128MP0003984_embryonic_growth_retardation0.80769209
129MP0001819_abnormal_immune_cell0.80048857
130MP0001270_distended_abdomen0.80016839
131MP0010155_abnormal_intestine_physiology0.79928209
132MP0002420_abnormal_adaptive_immunity0.79787614
133MP0005671_abnormal_response_to0.79747412
134MP0004197_abnormal_fetal_growth/weight/0.79479502
135MP0000750_abnormal_muscle_regeneration0.79473854
136MP0002088_abnormal_embryonic_growth/wei0.79289049
137MP0005464_abnormal_platelet_physiology0.77657075
138MP0010307_abnormal_tumor_latency0.77442405
139MP0000858_altered_metastatic_potential0.77222491
140MP0002452_abnormal_antigen_presenting0.77081209
141MP0003195_calcinosis0.76444385
142MP0001905_abnormal_dopamine_level0.75190923
143MP0005666_abnormal_adipose_tissue0.75072823
144MP0009931_abnormal_skin_appearance0.72639798
145MP0008961_abnormal_basal_metabolism0.72586904
146MP0005076_abnormal_cell_differentiation0.71536700

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)4.71605406
2Reticulocytopenia (HP:0001896)4.53618065
3Abnormal number of erythroid precursors (HP:0012131)4.29589493
4Abnormality of cells of the erythroid lineage (HP:0012130)4.23030331
5Colon cancer (HP:0003003)3.78667428
6Abnormality of pyrimidine metabolism (HP:0004353)3.65625224
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46537827
8Opisthotonus (HP:0002179)3.29655749
9Birth length less than 3rd percentile (HP:0003561)3.09628888
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.08223062
11Increased muscle lipid content (HP:0009058)3.05473828
12Aplastic anemia (HP:0001915)3.05050781
13Mesangial abnormality (HP:0001966)3.03351990
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.01332676
15Neonatal respiratory distress (HP:0002643)3.00656743
16Pallor (HP:0000980)2.91667402
17Seborrheic dermatitis (HP:0001051)2.91304360
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88855307
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88855307
20Hypobetalipoproteinemia (HP:0003563)2.88426971
21Microvesicular hepatic steatosis (HP:0001414)2.84574640
22Microretrognathia (HP:0000308)2.82935991
23Progressive microcephaly (HP:0000253)2.76618386
24Oral leukoplakia (HP:0002745)2.74796251
25Hypertensive crisis (HP:0100735)2.73697457
26Macrocytic anemia (HP:0001972)2.71350608
27Intrahepatic cholestasis (HP:0001406)2.66233834
28Abnormality of the anterior horn cell (HP:0006802)2.63918831
29Degeneration of anterior horn cells (HP:0002398)2.63918831
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60183338
31Rib fusion (HP:0000902)2.55913049
32Reduced antithrombin III activity (HP:0001976)2.53348589
33Abnormality of reticulocytes (HP:0004312)2.51393298
34Ragged-red muscle fibers (HP:0003200)2.51160443
35Abnormality of T cell physiology (HP:0011840)2.49365577
36Breast hypoplasia (HP:0003187)2.48904804
37Squamous cell carcinoma (HP:0002860)2.47787219
38Panhypogammaglobulinemia (HP:0003139)2.45043856
39Abnormality of DNA repair (HP:0003254)2.44537809
40Poikiloderma (HP:0001029)2.44528667
41Cerebellar dysplasia (HP:0007033)2.44313371
42Dysostosis multiplex (HP:0000943)2.43488784
43Type I transferrin isoform profile (HP:0003642)2.43343812
44Growth hormone excess (HP:0000845)2.41981149
45Hemorrhage of the eye (HP:0011885)2.41017455
46Fatigue (HP:0012378)2.39822802
47Hyperthyroidism (HP:0000836)2.38018024
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37104378
49Abnormal gallbladder physiology (HP:0012438)2.36330434
50Cholecystitis (HP:0001082)2.36330434
51Increased intramyocellular lipid droplets (HP:0012240)2.35243538
52Stridor (HP:0010307)2.30351351
53Thrombocytosis (HP:0001894)2.29494254
54Severe visual impairment (HP:0001141)2.27549156
55Cerebral palsy (HP:0100021)2.27187470
56Attenuation of retinal blood vessels (HP:0007843)2.27022107
57Cortical visual impairment (HP:0100704)2.24990491
58Facial hemangioma (HP:0000329)2.22247935
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20032782
60Cholelithiasis (HP:0001081)2.19769020
61Abnormality of lateral ventricle (HP:0030047)2.18802227
62Ulnar bowing (HP:0003031)2.18008526
6311 pairs of ribs (HP:0000878)2.17353572
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17223368
65Abnormality of the ileum (HP:0001549)2.17164833
66Pancytopenia (HP:0001876)2.16612396
67Annular pancreas (HP:0001734)2.16596058
68Villous atrophy (HP:0011473)2.16496526
69Abnormality of small intestinal villus morphology (HP:0011472)2.16496526
70Truncus arteriosus (HP:0001660)2.15474474
71Abnormal protein glycosylation (HP:0012346)2.15101643
72Abnormal glycosylation (HP:0012345)2.15101643
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15101643
74Abnormal protein N-linked glycosylation (HP:0012347)2.15101643
75Atelectasis (HP:0100750)2.14612016
76Hepatocellular carcinoma (HP:0001402)2.14149571
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12729664
78Hyperbilirubinemia (HP:0002904)2.10245183
79Mucopolysacchariduria (HP:0008155)2.09549503
80Urinary glycosaminoglycan excretion (HP:0003541)2.09549503
81Selective tooth agenesis (HP:0001592)2.08460098
82Abnormality of the costochondral junction (HP:0000919)2.08007049
83Muscle fiber atrophy (HP:0100295)2.07206283
84Abnormality of nucleobase metabolism (HP:0010932)2.06903746
85Renal Fanconi syndrome (HP:0001994)2.05874975
86Increased serum ferritin (HP:0003281)2.05619357
87Failure to thrive in infancy (HP:0001531)2.05608505
88Joint stiffness (HP:0001387)2.05595601
89Granulocytopenia (HP:0001913)2.05411453
90Abnormality of polysaccharide metabolism (HP:0011012)2.05107766
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05107766
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05107766
93Meckel diverticulum (HP:0002245)2.04898069
94Lipid accumulation in hepatocytes (HP:0006561)2.04861927
95Chromsome breakage (HP:0040012)2.04595569
96Progressive muscle weakness (HP:0003323)2.04308310
97Purpura (HP:0000979)2.03715625
98Petechiae (HP:0000967)2.02790333
99Medulloblastoma (HP:0002885)2.01457988
100Abnormality of the preputium (HP:0100587)2.00872861
101Male infertility (HP:0003251)2.00303415
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.00297265
103Absent epiphyses (HP:0010577)2.00297265
104Abnormality of T cells (HP:0002843)1.99824334
105Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98823660
106Joint hemorrhage (HP:0005261)1.97739636
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.97003114
108Nasal polyposis (HP:0100582)1.95896426
109Myelodysplasia (HP:0002863)1.95806673
110Thin bony cortex (HP:0002753)1.95180644
111Delayed CNS myelination (HP:0002188)1.95152939
112Flattened epiphyses (HP:0003071)1.95029786
113Deep venous thrombosis (HP:0002625)1.93788539
114Prolonged partial thromboplastin time (HP:0003645)1.93550024
115Absent thumb (HP:0009777)1.93144669
116Reticulocytosis (HP:0001923)1.93007078
117Severe combined immunodeficiency (HP:0004430)1.92919376
118Back pain (HP:0003418)1.92489400
119Spastic paraparesis (HP:0002313)1.92253079
120Entropion (HP:0000621)1.91901986
121Myopathic facies (HP:0002058)1.91751273
122Spastic diplegia (HP:0001264)1.91261167
123Late onset (HP:0003584)1.91004999
124Basal cell carcinoma (HP:0002671)1.90581942
125Abnormality of the gallbladder (HP:0005264)1.90379900
126Hyperammonemia (HP:0001987)1.89496955
127Vertebral compression fractures (HP:0002953)1.89178806
128Abnormality of sulfur amino acid metabolism (HP:0004339)1.88875218
129Abnormality of the fingertips (HP:0001211)1.88803441
130Optic nerve coloboma (HP:0000588)1.88493136
131Aplasia/Hypoplasia of the thymus (HP:0010515)1.87322713
132Carpal bone hypoplasia (HP:0001498)1.86153111
133Epidermoid cyst (HP:0200040)1.85658899
134Vaginal fistula (HP:0004320)1.84763589
135Abnormality of the nasal mucosa (HP:0000433)1.84312814
136Ketosis (HP:0001946)1.83307846
137Easy fatigability (HP:0003388)1.82353213
138Abnormal gallbladder morphology (HP:0012437)1.82319879
139Retinal dysplasia (HP:0007973)1.81953170
140Long palpebral fissure (HP:0000637)1.80667066
141Progressive external ophthalmoplegia (HP:0000590)1.80172469
142Hypoplasia of the thymus (HP:0000778)1.79860523
143J-shaped sella turcica (HP:0002680)1.78778234
144Hyperglycinuria (HP:0003108)1.78745381
145Impaired platelet aggregation (HP:0003540)1.78686169
146Abnormal platelet function (HP:0011869)1.78686169
147Retinal atrophy (HP:0001105)1.78457219
148IgM deficiency (HP:0002850)1.77572145
149Hand muscle atrophy (HP:0009130)1.77360852
150Hypergonadotropic hypogonadism (HP:0000815)1.76657210
151Increased serum lactate (HP:0002151)1.76052220
152Dysautonomia (HP:0002459)1.74650074
153Occipital encephalocele (HP:0002085)1.74632561
154Hypoglycemic coma (HP:0001325)1.73641847
155Hyperglycinemia (HP:0002154)1.73495207
156Abnormality of chromosome stability (HP:0003220)1.72749563
157Dicarboxylic aciduria (HP:0003215)1.71925550
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71925550
159Multiple enchondromatosis (HP:0005701)1.71820861
160Brushfield spots (HP:0001088)1.71279950
161Rough bone trabeculation (HP:0100670)1.69772380
162Duodenal stenosis (HP:0100867)1.69499154
163Small intestinal stenosis (HP:0012848)1.69499154
164Abnormal spermatogenesis (HP:0008669)1.65102687
165Abnormality of fatty-acid metabolism (HP:0004359)1.63535431
166Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63426531
167Megaloblastic anemia (HP:0001889)1.63291684
168Elevated erythrocyte sedimentation rate (HP:0003565)1.62819458
169Patellar aplasia (HP:0006443)1.62439664
170Abnormality of serum amino acid levels (HP:0003112)1.62171077
171Xanthomatosis (HP:0000991)1.62050441
172Cellular immunodeficiency (HP:0005374)1.61097007
173Generalized aminoaciduria (HP:0002909)1.61088198
174Poikilocytosis (HP:0004447)1.60365350
175Abnormal delayed hypersensitivity skin test (HP:0002963)1.60354682
176Abnormality of the intrinsic pathway (HP:0010989)1.60153037
177Viral hepatitis (HP:0006562)1.59879511
178Secondary amenorrhea (HP:0000869)1.59226537
179Acanthocytosis (HP:0001927)1.58693194
180Anterior segment dysgenesis (HP:0007700)1.57988182
181Abnormality of glycine metabolism (HP:0010895)1.57697610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.39188105
2WEE12.80902268
3MAPK152.79527689
4EIF2AK12.73940637
5BCKDK2.73488635
6NEK22.48758601
7BRSK22.47680060
8ACVR1B2.40031126
9ERN12.39679459
10NME22.32984761
11PRKD32.18037831
12MAP4K12.13877680
13SIK22.13539391
14STK162.09305537
15PIM22.02149898
16PRPF4B2.01779920
17MAP3K101.98718136
18DYRK31.87770433
19CDC71.87150595
20EIF2AK31.86708252
21BRSK11.86686303
22SMG11.84557007
23CDK71.69909548
24TESK21.68055180
25TLK11.64971186
26PRKD21.62692584
27SCYL21.61780186
28PASK1.61425217
29ICK1.58095976
30FLT31.49657742
31MAP2K31.48108475
32PLK11.45145829
33TNK21.44935129
34MAP3K111.41994392
35RPS6KA41.41804721
36STK101.41472468
37VRK11.39776486
38MAP3K31.39525218
39ATR1.37110015
40TAOK21.34244804
41CDK41.33116145
42TTK1.32804906
43KDR1.29174392
44TYK21.24556084
45PLK41.22411305
46KIT1.21836225
47DAPK11.18357391
48VRK21.17773679
49ZAP701.17240378
50CAMK1D1.16969920
51GRK61.16880320
52AURKA1.14030762
53RPS6KB21.13124147
54TESK11.12839459
55TRIB31.11227782
56CDK121.11185787
57PIM11.11071630
58SRPK11.07150930
59WNK41.04509097
60MAP3K81.01885813
61RPS6KA20.96231435
62CCNB10.96218092
63AURKB0.94766178
64BRAF0.94153166
65MAP3K140.93551086
66TBK10.91978034
67PAK40.90996074
68EEF2K0.90905481
69TGFBR10.88932344
70CHEK20.87759994
71BTK0.84847318
72SIK30.84238807
73FES0.83059344
74SIK10.82127369
75PKN20.81694184
76LRRK20.79903364
77CAMKK20.78769124
78RPS6KA50.78532822
79PDK20.75067892
80TEC0.74919217
81RPS6KL10.72784477
82RPS6KC10.72784477
83CSF1R0.72419180
84RIPK40.71062398
85RPS6KA10.70588519
86CAMK1G0.70513445
87EPHA20.70274257
88STK40.69713508
89CSNK1G30.69657295
90IRAK30.69512300
91IRAK20.66280391
92CHEK10.65922540
93MAP2K20.63837823
94MAPK110.63757862
95PRKCI0.62910777
96MAPKAPK30.62618706
97CAMKK10.62556111
98MARK20.61875896
99MTOR0.59916069
100RPS6KA60.59645739
101TAOK30.58163560
102MAP2K60.57719702
103EIF2AK20.57544958
104FGFR40.56838939
105TSSK60.54915703
106TXK0.54165388
107PDPK10.53072304
108RAF10.51430543
109CSNK2A10.51379863
110MAP4K20.50933952
111CDK80.49673203
112NLK0.49362833
113PAK10.48542656
114CDK20.47914243
115MARK30.47847166
116MAPK40.47605832
117MAPK30.46753560
118MAP3K60.46675257
119JAK30.46665093
120CSNK1A1L0.46289936
121IKBKB0.46114431
122CHUK0.45750125
123DYRK1B0.45727672
124BLK0.45557866
125MELK0.45346908
126MAP3K70.44682440
127NUAK10.44272254
128PRKAA10.44045164
129ZAK0.43976466
130PRKD10.42781729
131DAPK30.42386621
132BMX0.41670895
133SYK0.40491418
134CSNK2A20.40141296
135STK380.39932356
136MATK0.38751075
137PKN10.37836530
138BRD40.37235575
139IKBKE0.37161720
140ARAF0.36817980
141TAOK10.36054184
142TGFBR20.34924625
143DYRK20.34333609
144ABL20.33687382
145IRAK40.33012567
146ADRBK20.32538637
147NME10.32254395
148MAPK80.31929425
149ILK0.31164354
150MKNK10.30808970
151MAPKAPK20.29038046

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54263407
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.67343832
3Other glycan degradation_Homo sapiens_hsa005113.64696233
4Mismatch repair_Homo sapiens_hsa034303.48606154
5Ribosome_Homo sapiens_hsa030103.11521410
6Glycosaminoglycan degradation_Homo sapiens_hsa005313.05781612
7Base excision repair_Homo sapiens_hsa034102.78373354
8Selenocompound metabolism_Homo sapiens_hsa004502.72742771
9One carbon pool by folate_Homo sapiens_hsa006702.45059656
10Spliceosome_Homo sapiens_hsa030402.41898375
11Pyrimidine metabolism_Homo sapiens_hsa002402.27262952
12Proteasome_Homo sapiens_hsa030502.26767866
13Nucleotide excision repair_Homo sapiens_hsa034202.11262000
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05188248
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02715173
16RNA polymerase_Homo sapiens_hsa030202.02501333
17Folate biosynthesis_Homo sapiens_hsa007901.99832095
18Homologous recombination_Homo sapiens_hsa034401.92230404
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.88226854
20RNA transport_Homo sapiens_hsa030131.82078474
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.78811524
22Cell cycle_Homo sapiens_hsa041101.71635668
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67677327
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.59030870
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56262880
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54871173
27Sulfur relay system_Homo sapiens_hsa041221.51440250
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49902380
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44127766
30Fanconi anemia pathway_Homo sapiens_hsa034601.36658216
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32920576
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.31052055
33Pentose phosphate pathway_Homo sapiens_hsa000301.27954433
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26982023
35Biosynthesis of amino acids_Homo sapiens_hsa012301.20248503
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17279463
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.16810856
38Tryptophan metabolism_Homo sapiens_hsa003801.14980602
39Fatty acid elongation_Homo sapiens_hsa000621.10714589
40Shigellosis_Homo sapiens_hsa051311.09852980
41Sulfur metabolism_Homo sapiens_hsa009201.09022478
42Non-homologous end-joining_Homo sapiens_hsa034501.08825336
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07884697
44p53 signaling pathway_Homo sapiens_hsa041151.07164267
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07153478
46Inositol phosphate metabolism_Homo sapiens_hsa005621.03621561
47Regulation of autophagy_Homo sapiens_hsa041401.02311620
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.01811765
49Glutathione metabolism_Homo sapiens_hsa004801.01279554
50Non-small cell lung cancer_Homo sapiens_hsa052231.00166574
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00152776
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99884730
53Antigen processing and presentation_Homo sapiens_hsa046120.99400313
54Protein export_Homo sapiens_hsa030600.97897352
55Purine metabolism_Homo sapiens_hsa002300.97803862
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97133964
57Carbon metabolism_Homo sapiens_hsa012000.94020222
58Fatty acid degradation_Homo sapiens_hsa000710.92532495
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89814235
60N-Glycan biosynthesis_Homo sapiens_hsa005100.89359389
61Lysosome_Homo sapiens_hsa041420.89322613
62Peroxisome_Homo sapiens_hsa041460.89031624
63RNA degradation_Homo sapiens_hsa030180.87651486
64Caffeine metabolism_Homo sapiens_hsa002320.86052682
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85743602
66Primary immunodeficiency_Homo sapiens_hsa053400.82743730
67Herpes simplex infection_Homo sapiens_hsa051680.79933471
68beta-Alanine metabolism_Homo sapiens_hsa004100.79820876
69VEGF signaling pathway_Homo sapiens_hsa043700.77865212
70Phenylalanine metabolism_Homo sapiens_hsa003600.76866275
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76492202
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.76261099
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74994548
74Fat digestion and absorption_Homo sapiens_hsa049750.70671588
75Fructose and mannose metabolism_Homo sapiens_hsa000510.69550173
76Basal transcription factors_Homo sapiens_hsa030220.68660659
77Vitamin B6 metabolism_Homo sapiens_hsa007500.67793617
78mTOR signaling pathway_Homo sapiens_hsa041500.66168568
79B cell receptor signaling pathway_Homo sapiens_hsa046620.65994336
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65746488
81Galactose metabolism_Homo sapiens_hsa000520.65445426
82mRNA surveillance pathway_Homo sapiens_hsa030150.63862877
83Epstein-Barr virus infection_Homo sapiens_hsa051690.63563494
84Pyruvate metabolism_Homo sapiens_hsa006200.63462225
85Complement and coagulation cascades_Homo sapiens_hsa046100.62504446
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61871082
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61572781
88Alcoholism_Homo sapiens_hsa050340.61134603
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60088285
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.59826129
91Arginine biosynthesis_Homo sapiens_hsa002200.59227707
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.58793465
93Lysine degradation_Homo sapiens_hsa003100.58722522
94Leishmaniasis_Homo sapiens_hsa051400.55772708
95Endocytosis_Homo sapiens_hsa041440.55230073
96Systemic lupus erythematosus_Homo sapiens_hsa053220.54633231
97Propanoate metabolism_Homo sapiens_hsa006400.54270029
98Thyroid cancer_Homo sapiens_hsa052160.53014146
99Arginine and proline metabolism_Homo sapiens_hsa003300.52902013
100Acute myeloid leukemia_Homo sapiens_hsa052210.52502012
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52331182
102Chemical carcinogenesis_Homo sapiens_hsa052040.51170041
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50998055
104Metabolic pathways_Homo sapiens_hsa011000.49426751
105Histidine metabolism_Homo sapiens_hsa003400.48233912
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.47255998
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47100635
108Vibrio cholerae infection_Homo sapiens_hsa051100.44999221
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44759454
110Tyrosine metabolism_Homo sapiens_hsa003500.43900919
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43769237
112Hepatitis B_Homo sapiens_hsa051610.43245809
113Chronic myeloid leukemia_Homo sapiens_hsa052200.42817691
114Apoptosis_Homo sapiens_hsa042100.41708142
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41365137
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.40844656
117Retinol metabolism_Homo sapiens_hsa008300.40382929
118Legionellosis_Homo sapiens_hsa051340.40341290
119Starch and sucrose metabolism_Homo sapiens_hsa005000.39890872
120Viral carcinogenesis_Homo sapiens_hsa052030.39508336
121Glycerolipid metabolism_Homo sapiens_hsa005610.38953520
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37345516
123HTLV-I infection_Homo sapiens_hsa051660.37204604
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37171872
125AMPK signaling pathway_Homo sapiens_hsa041520.36658758
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36197804
127ABC transporters_Homo sapiens_hsa020100.35353265
128Notch signaling pathway_Homo sapiens_hsa043300.34528998
129Bladder cancer_Homo sapiens_hsa052190.31528342
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30030226
131Measles_Homo sapiens_hsa051620.29914191
132Synaptic vesicle cycle_Homo sapiens_hsa047210.29689783
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29105449
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28711865
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28208932
136Osteoclast differentiation_Homo sapiens_hsa043800.27737136
137Fatty acid metabolism_Homo sapiens_hsa012120.27177388
138Staphylococcus aureus infection_Homo sapiens_hsa051500.26197212

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