DYDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that contains a DPY30 domain. The encoded protein is involved in acrosome formation during spermatid development. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.65325217
2acrosome reaction (GO:0007340)9.49087808
3cell-cell recognition (GO:0009988)9.47197662
4binding of sperm to zona pellucida (GO:0007339)9.17913025
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.00610071
6spermatid development (GO:0007286)8.40332839
7piRNA metabolic process (GO:0034587)8.13441658
8regulation of cilium movement (GO:0003352)7.72242320
9single fertilization (GO:0007338)7.44096975
10male meiosis (GO:0007140)7.24347856
11synaptonemal complex organization (GO:0070193)6.59020664
12sperm capacitation (GO:0048240)6.38552493
13synaptonemal complex assembly (GO:0007130)6.28007411
14ventricular system development (GO:0021591)6.07317403
15fertilization (GO:0009566)5.96115868
16behavioral response to nicotine (GO:0035095)5.91479193
17microtubule depolymerization (GO:0007019)5.60563688
18spermatid nucleus differentiation (GO:0007289)5.41757079
19spermatogenesis (GO:0007283)5.38282183
20male gamete generation (GO:0048232)5.36229950
21negative regulation of inclusion body assembly (GO:0090084)5.33734158
22axoneme assembly (GO:0035082)5.31721604
23gamete generation (GO:0007276)4.95448638
24DNA methylation involved in gamete generation (GO:0043046)4.95368143
25calcium ion-dependent exocytosis (GO:0017156)4.78874557
26microtubule severing (GO:0051013)4.71791529
27cellular process involved in reproduction in multicellular organism (GO:0022412)4.71118738
28germ cell development (GO:0007281)4.69996242
29male meiosis I (GO:0007141)4.69966634
30cell recognition (GO:0008037)4.67753481
31organic cation transport (GO:0015695)4.62387093
32intraciliary transport (GO:0042073)4.47374950
33protein localization to cilium (GO:0061512)4.46878434
34regulation of inclusion body assembly (GO:0090083)4.37756738
35regulation of microtubule-based movement (GO:0060632)4.37391501
36chromosome organization involved in meiosis (GO:0070192)4.37205012
37meiotic nuclear division (GO:0007126)4.24086393
38centriole assembly (GO:0098534)4.14256838
39cilium morphogenesis (GO:0060271)3.88641210
40multicellular organismal reproductive process (GO:0048609)3.88110593
41protein complex biogenesis (GO:0070271)3.87395378
42cilium organization (GO:0044782)3.87067612
43centriole replication (GO:0007099)3.84729172
44meiosis I (GO:0007127)3.83589083
45water-soluble vitamin biosynthetic process (GO:0042364)3.83215106
46fucose catabolic process (GO:0019317)3.83025840
47L-fucose metabolic process (GO:0042354)3.83025840
48L-fucose catabolic process (GO:0042355)3.83025840
49response to pheromone (GO:0019236)3.79675632
50cilium assembly (GO:0042384)3.78420659
51monoubiquitinated protein deubiquitination (GO:0035520)3.78368330
52meiotic cell cycle (GO:0051321)3.74545959
53microtubule-based movement (GO:0007018)3.74184034
54regulation of chromatin binding (GO:0035561)3.71079948
55GTP biosynthetic process (GO:0006183)3.67265856
56platelet dense granule organization (GO:0060155)3.63846153
57nucleoside diphosphate phosphorylation (GO:0006165)3.61883087
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58129172
59ATP synthesis coupled proton transport (GO:0015986)3.58129172
60mitochondrial respiratory chain complex assembly (GO:0033108)3.56934526
61DNA deamination (GO:0045006)3.53057299
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52907042
63cellular component assembly involved in morphogenesis (GO:0010927)3.52255463
64protein K11-linked deubiquitination (GO:0035871)3.49658821
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.49196715
66NADH dehydrogenase complex assembly (GO:0010257)3.49196715
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49196715
68left/right pattern formation (GO:0060972)3.43492965
69seminiferous tubule development (GO:0072520)3.38628568
70glycerol ether metabolic process (GO:0006662)3.37985103
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35892822
72protein polyglutamylation (GO:0018095)3.30133470
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26432075
74single strand break repair (GO:0000012)3.24478182
75UTP biosynthetic process (GO:0006228)3.24200026
76protein-cofactor linkage (GO:0018065)3.23372882
77polyol catabolic process (GO:0046174)3.20884700
78nephron epithelium morphogenesis (GO:0072088)3.19164659
79nephron tubule morphogenesis (GO:0072078)3.19164659
80chaperone-mediated protein complex assembly (GO:0051131)3.18769222
81gene silencing by RNA (GO:0031047)3.18201753
82left/right axis specification (GO:0070986)3.17769298
83negative regulation of telomere maintenance (GO:0032205)3.10913516
84ether metabolic process (GO:0018904)3.10841992
85indolalkylamine metabolic process (GO:0006586)3.09510549
86multicellular organismal development (GO:0007275)3.08460408
87reciprocal meiotic recombination (GO:0007131)3.08014303
88reciprocal DNA recombination (GO:0035825)3.08014303
89microtubule polymerization or depolymerization (GO:0031109)3.04274924
90tryptophan catabolic process (GO:0006569)3.03456125
91indole-containing compound catabolic process (GO:0042436)3.03456125
92indolalkylamine catabolic process (GO:0046218)3.03456125
93cytochrome complex assembly (GO:0017004)3.03299746
94respiratory chain complex IV assembly (GO:0008535)3.02770087
95kidney morphogenesis (GO:0060993)3.02041745
96regulation of protein polyubiquitination (GO:1902914)3.02002674
97microtubule bundle formation (GO:0001578)3.01082590
98alditol metabolic process (GO:0019400)2.99523194
99detection of light stimulus involved in sensory perception (GO:0050962)2.98897064
100detection of light stimulus involved in visual perception (GO:0050908)2.98897064
101regulation of meiosis I (GO:0060631)2.97935274
102UTP metabolic process (GO:0046051)2.96862665
103somite development (GO:0061053)2.95357394
104sequestering of actin monomers (GO:0042989)2.94884978
105lactate metabolic process (GO:0006089)2.93888469
106regulation of centriole replication (GO:0046599)2.90906515
107electron transport chain (GO:0022900)2.89812348
108nonmotile primary cilium assembly (GO:0035058)2.87731580
109establishment of protein localization to mitochondrial membrane (GO:0090151)2.85043164
110sulfation (GO:0051923)2.83225773
111genitalia morphogenesis (GO:0035112)2.82502547
112synaptic transmission, cholinergic (GO:0007271)2.81901654
113glycerol metabolic process (GO:0006071)2.79981056
114respiratory electron transport chain (GO:0022904)2.79775735
115cornea development in camera-type eye (GO:0061303)2.77627081
116dopamine transport (GO:0015872)2.75311534
117guanosine-containing compound biosynthetic process (GO:1901070)2.74671949
118kynurenine metabolic process (GO:0070189)2.73914149
119gamma-aminobutyric acid transport (GO:0015812)2.71795881
120preassembly of GPI anchor in ER membrane (GO:0016254)2.71129756
121ubiquinone biosynthetic process (GO:0006744)2.69518464
122pyrimidine nucleobase catabolic process (GO:0006208)2.68613651
123hindbrain development (GO:0030902)2.67843869
124negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67506755
125tryptophan metabolic process (GO:0006568)2.67283068
126positive regulation of oligodendrocyte differentiation (GO:0048714)2.66081381
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64820293
128ubiquinone metabolic process (GO:0006743)2.64648978
129regulation of neurotransmitter uptake (GO:0051580)2.64164656
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.63634710
131protein neddylation (GO:0045116)2.63051479
132chromosome condensation (GO:0030261)2.62184282
133transmission of nerve impulse (GO:0019226)2.61635828
134protein refolding (GO:0042026)2.61227011
135regulation of spindle checkpoint (GO:0090231)2.61008685
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60789025
137rRNA catabolic process (GO:0016075)2.59969851
138sexual reproduction (GO:0019953)2.59448307
139spinal cord motor neuron differentiation (GO:0021522)2.57682533
140regulation of hexokinase activity (GO:1903299)2.57378377
141regulation of glucokinase activity (GO:0033131)2.57378377
142neuron fate determination (GO:0048664)2.56419871
143synapsis (GO:0007129)2.56390757
144meiotic cell cycle process (GO:1903046)2.54858772
145indole-containing compound metabolic process (GO:0042430)2.52668905
146cellular ketone body metabolic process (GO:0046950)2.51611690
147renal tubule morphogenesis (GO:0061333)2.51572281
148glycerophospholipid catabolic process (GO:0046475)2.50096377
149regulation of posttranscriptional gene silencing (GO:0060147)2.49707383
150regulation of gene silencing by miRNA (GO:0060964)2.49707383
151regulation of gene silencing by RNA (GO:0060966)2.49707383
152amino-acid betaine transport (GO:0015838)2.49487448
153carnitine transport (GO:0015879)2.49487448
154regulation of action potential (GO:0098900)2.49249301
155photoreceptor cell development (GO:0042461)2.49179241
156negative regulation of mast cell activation (GO:0033004)2.48973143
157neuronal action potential (GO:0019228)2.48113788
158CTP metabolic process (GO:0046036)2.48063930
159CTP biosynthetic process (GO:0006241)2.48063930
160proton transport (GO:0015992)2.46786041
161postsynaptic membrane organization (GO:0001941)2.45498955
162hydrogen ion transmembrane transport (GO:1902600)2.45108023
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45051899
164reflex (GO:0060004)2.44564132
165cilium or flagellum-dependent cell motility (GO:0001539)15.6599463
166fusion of sperm to egg plasma membrane (GO:0007342)14.4176952
167cell wall macromolecule catabolic process (GO:0016998)13.6488071
168cell wall macromolecule metabolic process (GO:0044036)13.6488071
169axonemal dynein complex assembly (GO:0070286)12.0972304
170multicellular organism reproduction (GO:0032504)11.6700433
171sperm motility (GO:0030317)11.0218320
172plasma membrane fusion (GO:0045026)10.9485931
173motile cilium assembly (GO:0044458)10.6983676
174sperm-egg recognition (GO:0035036)10.5722591
175epithelial cilium movement (GO:0003351)10.5704351
176acrosome assembly (GO:0001675)10.4991680
177cilium movement (GO:0003341)10.3835952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.67204368
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.16202119
3EZH2_22144423_ChIP-Seq_EOC_Human4.40407792
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.70170637
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77823318
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.73977221
7VDR_22108803_ChIP-Seq_LS180_Human2.57805941
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57044420
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37246441
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33311193
11GBX2_23144817_ChIP-Seq_PC3_Human2.18688960
12KAP1_22055183_ChIP-Seq_ESCs_Mouse2.17192620
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15299439
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.13344319
15IGF1R_20145208_ChIP-Seq_DFB_Human2.12596932
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.03480535
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02035287
18FUS_26573619_Chip-Seq_HEK293_Human1.96542428
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92996262
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92974372
21EWS_26573619_Chip-Seq_HEK293_Human1.92133407
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89660953
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86260872
24ZNF274_21170338_ChIP-Seq_K562_Hela1.84663356
25TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.84040766
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83832407
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82793106
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.81499524
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81215779
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.78727915
31P300_19829295_ChIP-Seq_ESCs_Human1.78191583
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78185352
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.77753586
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75519650
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.74711088
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.73903467
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72227423
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71466244
39MYC_18940864_ChIP-ChIP_HL60_Human1.71204426
40KDM2B_26808549_Chip-Seq_REH_Human1.61326274
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.61249285
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60720712
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59717651
44STAT1_17558387_ChIP-Seq_HELA_Human1.57483508
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57151339
46IRF1_19129219_ChIP-ChIP_H3396_Human1.55917046
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55580320
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54536193
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52680724
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51571142
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.49645574
52TP53_22573176_ChIP-Seq_HFKS_Human1.45069391
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44822271
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42342184
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42237923
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41881136
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.41843078
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41166012
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.40644290
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40644290
61BCAT_22108803_ChIP-Seq_LS180_Human1.40143254
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39813786
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36983988
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.36158778
65* GATA3_21878914_ChIP-Seq_MCF-7_Human1.33419137
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.33332786
67P53_22387025_ChIP-Seq_ESCs_Mouse1.32410393
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.29913109
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29895470
70AR_25329375_ChIP-Seq_VCAP_Human1.29252431
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.28994274
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.28596569
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.28493348
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28035631
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.27768795
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27126635
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27004394
78SOX2_19829295_ChIP-Seq_ESCs_Human1.26754160
79NANOG_19829295_ChIP-Seq_ESCs_Human1.26754160
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26620050
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.24813625
82TAF15_26573619_Chip-Seq_HEK293_Human1.24660969
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23634801
84CBP_20019798_ChIP-Seq_JUKART_Human1.23634801
85STAT3_23295773_ChIP-Seq_U87_Human1.23389065
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23375028
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.23336208
88NCOR_22424771_ChIP-Seq_293T_Human1.23167929
89* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23121900
90RNF2_27304074_Chip-Seq_NSC_Mouse1.22362440
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22166342
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21944234
93GF1_26923725_Chip-Seq_HPCs_Mouse1.20935539
94P300_18555785_Chip-Seq_ESCs_Mouse1.20651690
95AR_20517297_ChIP-Seq_VCAP_Human1.20055303
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18685446
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18469123
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17971123
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17971123
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16550462
101REST_21632747_ChIP-Seq_MESCs_Mouse1.16103411
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15449312
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15074858
104RUNX2_22187159_ChIP-Seq_PCA_Human1.15015999
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.14234078
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14137441
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.14135864
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13909163
109GATA3_21867929_ChIP-Seq_TH1_Mouse1.12080594
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12075211
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10778246
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10679020
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.10465405
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10346266
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.10326175
116TCF4_22108803_ChIP-Seq_LS180_Human1.10238677
117HOXB7_26014856_ChIP-Seq_BT474_Human1.10075802
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09945595
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.09659108
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09531328
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09409703
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09358578
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08895170
124ELK1_19687146_ChIP-ChIP_HELA_Human1.08021481
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07960725
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.07911951
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.07887584
128P53_21459846_ChIP-Seq_SAOS-2_Human1.07360112
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.07302779
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07063603
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07004059
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06854539
133VDR_23849224_ChIP-Seq_CD4+_Human1.06843412
134ERA_21632823_ChIP-Seq_H3396_Human1.05968454
135FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05842332
136MYC_19829295_ChIP-Seq_ESCs_Human1.05490894
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04814681
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04256868
139RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02693055
140PU1_27457419_Chip-Seq_LIVER_Mouse1.02286697
141TAF2_19829295_ChIP-Seq_ESCs_Human1.02256896
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01478041
143CTCF_18555785_Chip-Seq_ESCs_Mouse1.00758420
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00040327
145* SOX9_26525672_Chip-Seq_HEART_Mouse1.00002068
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99682339
147JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99526962
148SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98422370
149SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98046576
150GF1B_26923725_Chip-Seq_HPCs_Mouse0.97809121
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.97594788
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.97316832
153ZFX_18555785_Chip-Seq_ESCs_Mouse0.96837779
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.96771850
155STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96694821
156EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96007622
157ER_23166858_ChIP-Seq_MCF-7_Human0.93402329
158SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92637920
159RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91215911
160TCF4_23295773_ChIP-Seq_U87_Human0.91196616
161NMYC_18555785_Chip-Seq_ESCs_Mouse0.90585421
162NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89376254
163STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88767508
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87190922
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86776430
166ESET_19884257_ChIP-Seq_ESCs_Mouse0.86175247
167SMAD4_21799915_ChIP-Seq_A2780_Human0.85971673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.54252799
2MP0001929_abnormal_gametogenesis5.12790284
3MP0008877_abnormal_DNA_methylation4.29788943
4MP0002653_abnormal_ependyma_morphology4.17990467
5MP0002210_abnormal_sex_determination3.71481981
6MP0001984_abnormal_olfaction3.25924106
7MP0001145_abnormal_male_reproductive3.04934141
8MP0002161_abnormal_fertility/fecundity3.03915076
9MP0002160_abnormal_reproductive_system2.89821313
10MP0000653_abnormal_sex_gland2.75321778
11MP0000569_abnormal_digit_pigmentation2.68088643
12MP0006292_abnormal_olfactory_placode2.51819050
13MP0008789_abnormal_olfactory_epithelium2.39149012
14MP0003878_abnormal_ear_physiology2.37698558
15MP0005377_hearing/vestibular/ear_phenot2.37698558
16MP0006072_abnormal_retinal_apoptosis2.29411370
17MP0004885_abnormal_endolymph2.27917179
18MP0005499_abnormal_olfactory_system2.19232988
19MP0005394_taste/olfaction_phenotype2.19232988
20MP0003880_abnormal_central_pattern2.17749948
21MP0002876_abnormal_thyroid_physiology2.03404781
22MP0005410_abnormal_fertilization13.6182465
23MP0002638_abnormal_pupillary_reflex1.96934642
24MP0005623_abnormal_meninges_morphology1.93846261
25MP0001968_abnormal_touch/_nociception1.92108133
26MP0005647_abnormal_sex_gland1.90247230
27MP0002837_dystrophic_cardiac_calcinosis1.89920473
28MP0003283_abnormal_digestive_organ1.89085433
29MP0003787_abnormal_imprinting1.83973751
30MP0001986_abnormal_taste_sensitivity1.81505619
31MP0009745_abnormal_behavioral_response1.77095020
32MP0005084_abnormal_gallbladder_morpholo1.73958326
33MP0003195_calcinosis1.72421218
34MP0004147_increased_porphyrin_level1.72323281
35MP0009379_abnormal_foot_pigmentation1.69179263
36MP0004142_abnormal_muscle_tone1.68124412
37MP0001485_abnormal_pinna_reflex1.67672734
38MP0000631_abnormal_neuroendocrine_gland1.59421167
39MP0005389_reproductive_system_phenotype1.57277674
40MP0001529_abnormal_vocalization1.51357670
41MP0005670_abnormal_white_adipose1.45353684
42MP0008057_abnormal_DNA_replication1.43081537
43MP0008004_abnormal_stomach_pH1.42522877
44MP0008872_abnormal_physiological_respon1.39246146
45MP0008058_abnormal_DNA_repair1.38634121
46MP0002928_abnormal_bile_duct1.36489309
47MP0001293_anophthalmia1.36084800
48MP0002572_abnormal_emotion/affect_behav1.31139895
49MP0001486_abnormal_startle_reflex1.29718778
50MP0006276_abnormal_autonomic_nervous1.29005893
51MP0003122_maternal_imprinting1.27443130
52MP0001905_abnormal_dopamine_level1.25492742
53MP0002102_abnormal_ear_morphology1.25464657
54MP0005423_abnormal_somatic_nervous1.24512069
55MP0001501_abnormal_sleep_pattern1.24302995
56MP0002277_abnormal_respiratory_mucosa1.23865946
57MP0002064_seizures1.23543708
58MP0000778_abnormal_nervous_system1.23077761
59MP0009046_muscle_twitch1.21224703
60MP0002735_abnormal_chemical_nociception1.16271996
61MP0003121_genomic_imprinting1.16211763
62MP0004043_abnormal_pH_regulation1.12510455
63MP0002067_abnormal_sensory_capabilities1.12095269
64MP0001502_abnormal_circadian_rhythm1.11944635
65MP0004233_abnormal_muscle_weight1.10603764
66MP0002282_abnormal_trachea_morphology1.10159658
67MP0001970_abnormal_pain_threshold1.07079039
68MP0002733_abnormal_thermal_nociception1.07001787
69MP0002095_abnormal_skin_pigmentation1.06279957
70MP0002063_abnormal_learning/memory/cond1.05528371
71MP0003635_abnormal_synaptic_transmissio1.02121996
72MP0002234_abnormal_pharynx_morphology0.97032453
73MP0002734_abnormal_mechanical_nocicepti0.96809042
74MP0000049_abnormal_middle_ear0.95945886
75MP0008995_early_reproductive_senescence0.95305843
76MP0005386_behavior/neurological_phenoty0.94967288
77MP0004924_abnormal_behavior0.94967288
78MP0002909_abnormal_adrenal_gland0.92918497
79MP0001765_abnormal_ion_homeostasis0.91654825
80MP0003937_abnormal_limbs/digits/tail_de0.89191948
81MP0000383_abnormal_hair_follicle0.88846923
82MP0002184_abnormal_innervation0.87662964
83MP0000566_synostosis0.87237922
84MP0005379_endocrine/exocrine_gland_phen0.85180937
85MP0003119_abnormal_digestive_system0.85135954
86MP0001440_abnormal_grooming_behavior0.83657261
87MP0002751_abnormal_autonomic_nervous0.82759675
88MP0003137_abnormal_impulse_conducting0.82621256
89MP0003011_delayed_dark_adaptation0.81014169
90MP0003646_muscle_fatigue0.77555329
91MP0004134_abnormal_chest_morphology0.75542236
92MP0004133_heterotaxia0.75423928
93MP0003136_yellow_coat_color0.75233047
94MP0003890_abnormal_embryonic-extraembry0.74645114
95MP0010094_abnormal_chromosome_stability0.73957331
96MP0000372_irregular_coat_pigmentation0.73584826
97MP0003786_premature_aging0.73381772
98MP0005645_abnormal_hypothalamus_physiol0.71869714
99MP0005551_abnormal_eye_electrophysiolog0.66744157
100MP0001119_abnormal_female_reproductive0.62291213
101MP0002233_abnormal_nose_morphology0.61789308
102MP0010030_abnormal_orbit_morphology0.55994045
103MP0002557_abnormal_social/conspecific_i0.52451884
104MP0005174_abnormal_tail_pigmentation0.52082923
105MP0003633_abnormal_nervous_system0.52012208
106MP0002938_white_spotting0.51259283
107MP0003699_abnormal_female_reproductive0.50062299
108MP0005636_abnormal_mineral_homeostasis0.49497252
109MP0005646_abnormal_pituitary_gland0.49169539
110MP0001764_abnormal_homeostasis0.48757192
111MP0000015_abnormal_ear_pigmentation0.47799344
112MP0001963_abnormal_hearing_physiology0.46715500
113MP0008007_abnormal_cellular_replicative0.46461000
114MP0002752_abnormal_somatic_nervous0.44073396
115MP0000026_abnormal_inner_ear0.43427376
116MP0004019_abnormal_vitamin_homeostasis0.43416969
117MP0001324_abnormal_eye_pigmentation0.42999289
118MP0002132_abnormal_respiratory_system0.42055992
119MP0003861_abnormal_nervous_system0.40841168
120MP0002229_neurodegeneration0.37892955
121MP0002152_abnormal_brain_morphology0.37724012
122MP0003115_abnormal_respiratory_system0.37658889
123MP0000358_abnormal_cell_content/0.37129795
124MP0005365_abnormal_bile_salt0.35750772
125MP0008875_abnormal_xenobiotic_pharmacok0.33841540
126MP0003631_nervous_system_phenotype0.33319569
127MP0005360_urolithiasis0.32307382
128MP0004811_abnormal_neuron_physiology0.31924832
129MP0003111_abnormal_nucleus_morphology0.27702501
130MP0005253_abnormal_eye_physiology0.27035627
131MP0004808_abnormal_hematopoietic_stem0.26987296
132MP0000427_abnormal_hair_cycle0.26818329
133MP0003942_abnormal_urinary_system0.26747953
134MP0001919_abnormal_reproductive_system0.26274870
135MP0003950_abnormal_plasma_membrane0.26187698
136MP0003879_abnormal_hair_cell0.25813226
137MP0002882_abnormal_neuron_morphology0.25417113
138MP0004742_abnormal_vestibular_system0.24972516
139MP0000432_abnormal_head_morphology0.24794199
140MP0002272_abnormal_nervous_system0.24530415
141MP0005187_abnormal_penis_morphology0.24258587
142MP0005535_abnormal_body_temperature0.23981147
143MP0002269_muscular_atrophy0.23949582
144MP0002736_abnormal_nociception_after0.23654883
145MP0009250_abnormal_appendicular_skeleto0.23246598
146MP0004381_abnormal_hair_follicle0.22854063
147MP0002133_abnormal_respiratory_system0.22067667
148MP0005388_respiratory_system_phenotype0.22067667
149MP0005195_abnormal_posterior_eye0.22049177
150MP0002116_abnormal_craniofacial_bone0.21997483
151MP0005391_vision/eye_phenotype0.21137506
152MP0009115_abnormal_fat_cell0.21123578
153MP0003936_abnormal_reproductive_system0.20473772
154MP0001851_eye_inflammation0.20448341
155MP0005397_hematopoietic_system_phenotyp0.20276614
156MP0001545_abnormal_hematopoietic_system0.20276614

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.88214040
2Abnormal respiratory epithelium morphology (HP:0012253)9.88214040
3Abnormal ciliary motility (HP:0012262)9.33913683
4Rhinitis (HP:0012384)8.76833926
5Chronic bronchitis (HP:0004469)6.98700689
6Nasal polyposis (HP:0100582)5.89186371
7Infertility (HP:0000789)5.64848555
8Bronchiectasis (HP:0002110)4.99724073
9Abnormality of the nasal mucosa (HP:0000433)4.78754010
10Medial flaring of the eyebrow (HP:0010747)3.98866302
11Male infertility (HP:0003251)3.96014164
12Bronchitis (HP:0012387)3.92121152
13Congenital stationary night blindness (HP:0007642)3.62941447
14Nephronophthisis (HP:0000090)3.59204723
15Recurrent sinusitis (HP:0011108)3.50047732
16Congenital primary aphakia (HP:0007707)3.40992410
17Gait imbalance (HP:0002141)3.40986420
18Type II lissencephaly (HP:0007260)3.08956915
19Nephrogenic diabetes insipidus (HP:0009806)3.00071204
20Recurrent otitis media (HP:0000403)2.97199880
21Tubulointerstitial nephritis (HP:0001970)2.95263731
22Acute necrotizing encephalopathy (HP:0006965)2.90039931
23Abnormality of the renal medulla (HP:0100957)2.76321819
24Pendular nystagmus (HP:0012043)2.70056256
25Mitochondrial inheritance (HP:0001427)2.69934876
26Poor coordination (HP:0002370)2.68152012
27Chronic sinusitis (HP:0011109)2.65960094
28Abnormality of midbrain morphology (HP:0002418)2.65770280
29Molar tooth sign on MRI (HP:0002419)2.65770280
30Congenital, generalized hypertrichosis (HP:0004540)2.60229280
31Abnormal rod and cone electroretinograms (HP:0008323)2.59719351
32Abolished electroretinogram (ERG) (HP:0000550)2.56670978
33Increased CSF lactate (HP:0002490)2.52251604
34Abnormal mitochondria in muscle tissue (HP:0008316)2.51890360
35Progressive macrocephaly (HP:0004481)2.50402328
36Pancreatic fibrosis (HP:0100732)2.50053171
37Polydipsia (HP:0001959)2.48010338
38Vaginal atresia (HP:0000148)2.45605660
39Attenuation of retinal blood vessels (HP:0007843)2.41727527
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40652103
41Supernumerary spleens (HP:0009799)2.39604726
42Genital tract atresia (HP:0001827)2.39521855
43Acute encephalopathy (HP:0006846)2.34354712
44Hyperventilation (HP:0002883)2.32889577
45True hermaphroditism (HP:0010459)2.30855568
46Abnormal biliary tract physiology (HP:0012439)2.30773792
47Bile duct proliferation (HP:0001408)2.30773792
48Decreased central vision (HP:0007663)2.21876482
49Furrowed tongue (HP:0000221)2.21766941
50Inability to walk (HP:0002540)2.21505704
51Abnormality of the labia minora (HP:0012880)2.20958770
52Concave nail (HP:0001598)2.19818724
53Postaxial foot polydactyly (HP:0001830)2.18718285
54Abnormal spermatogenesis (HP:0008669)2.13754872
55Lissencephaly (HP:0001339)2.13686772
56Methylmalonic acidemia (HP:0002912)2.13679273
57Increased corneal curvature (HP:0100692)2.12857030
58Keratoconus (HP:0000563)2.12857030
59Retinal dysplasia (HP:0007973)2.12174953
60Increased hepatocellular lipid droplets (HP:0006565)2.10420869
61Aplasia/Hypoplasia of the lens (HP:0008063)2.10085911
62Optic disc pallor (HP:0000543)2.09167706
633-Methylglutaconic aciduria (HP:0003535)2.09045259
64Abnormality of permanent molar morphology (HP:0011071)2.08810438
65Abnormality of the dental root (HP:0006486)2.08810438
66Taurodontia (HP:0000679)2.08810438
67Renal cortical cysts (HP:0000803)2.07478085
68Lipid accumulation in hepatocytes (HP:0006561)2.06713077
69Patellar aplasia (HP:0006443)2.06708608
70Optic nerve hypoplasia (HP:0000609)2.04601083
71Aplasia/Hypoplasia of the spleen (HP:0010451)2.04366431
72Polyuria (HP:0000103)2.02935844
73Tubulointerstitial abnormality (HP:0001969)2.02827534
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02680469
75Decreased circulating renin level (HP:0003351)2.00767417
76Aplasia/Hypoplasia of the patella (HP:0006498)2.00456953
77Tubular atrophy (HP:0000092)2.00333766
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9344369
79Dynein arm defect of respiratory motile cilia (HP:0012255)11.7382931
80Absent/shortened dynein arms (HP:0200106)11.7382931
81Abnormal respiratory motile cilium physiology (HP:0012261)10.5067574
82Cystic liver disease (HP:0006706)1.99265492
83Septo-optic dysplasia (HP:0100842)1.97543207
84Congenital hepatic fibrosis (HP:0002612)1.96965730
85Large for gestational age (HP:0001520)1.96757286
86Abnormality of molar morphology (HP:0011070)1.96618267
87Abnormality of molar (HP:0011077)1.96618267
88Occipital encephalocele (HP:0002085)1.96523270
89Abnormality of alanine metabolism (HP:0010916)1.95277718
90Hyperalaninemia (HP:0003348)1.95277718
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95277718
92Abnormality of dentin (HP:0010299)1.94108942
93Broad-based gait (HP:0002136)1.94055152
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.93961890
95Hepatocellular necrosis (HP:0001404)1.93712546
96Renal Fanconi syndrome (HP:0001994)1.93686634
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.92939211
98Progressive cerebellar ataxia (HP:0002073)1.92374838
99Abnormality of the lower motor neuron (HP:0002366)1.92327457
100Pancreatic cysts (HP:0001737)1.91993299
101Progressive inability to walk (HP:0002505)1.91141031
102Postaxial hand polydactyly (HP:0001162)1.90849092
103Impulsivity (HP:0100710)1.90425259
104Cerebellar dysplasia (HP:0007033)1.90161201
105Oligodactyly (hands) (HP:0001180)1.89269885
106Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88550332
107Recurrent bronchitis (HP:0002837)1.87734794
108Asplenia (HP:0001746)1.86959430
109Abnormality of the dental pulp (HP:0006479)1.86737239
110Limb dystonia (HP:0002451)1.86323876
111Methylmalonic aciduria (HP:0012120)1.85568374
112Azoospermia (HP:0000027)1.85051178
113Anophthalmia (HP:0000528)1.84538429
114Abnormal number of erythroid precursors (HP:0012131)1.84277423
115Hepatic necrosis (HP:0002605)1.82813188
116Short tibia (HP:0005736)1.81705337
117Aplasia/hypoplasia of the uterus (HP:0008684)1.80273260
118Colon cancer (HP:0003003)1.78222567
119Bony spicule pigmentary retinopathy (HP:0007737)1.77169806
120Facial cleft (HP:0002006)1.74346388
121Mesangial abnormality (HP:0001966)1.73440768
122Papillary thyroid carcinoma (HP:0002895)1.73291548
123Agitation (HP:0000713)1.72986235
124Stage 5 chronic kidney disease (HP:0003774)1.70953038
125Fibular hypoplasia (HP:0003038)1.66950306
126Gonadotropin excess (HP:0000837)1.65537405
127Oculomotor apraxia (HP:0000657)1.59221952
128Broad foot (HP:0001769)1.59097969
129Male pseudohermaphroditism (HP:0000037)1.54878301
130Amyotrophic lateral sclerosis (HP:0007354)1.48904705
131Tongue fasciculations (HP:0001308)1.48130613
132Median cleft lip (HP:0000161)1.47952021
133Short nail (HP:0001799)1.45621208
134Dental crowding (HP:0000678)1.45328690
135Short ribs (HP:0000773)1.44365539
136Renal dysplasia (HP:0000110)1.43635058
137Abnormality of the renal cortex (HP:0011035)1.36423187
138Muscle fibrillation (HP:0010546)1.36055743
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.35875198
140Urethral obstruction (HP:0000796)1.35099695
141Breast carcinoma (HP:0003002)1.33275809
142Impaired proprioception (HP:0010831)1.32249349
143Specific learning disability (HP:0001328)1.31038151
144Decreased testicular size (HP:0008734)1.27999506
145Broad distal phalanx of finger (HP:0009836)1.26194946
146Tubulointerstitial fibrosis (HP:0005576)1.25449332
147Anencephaly (HP:0002323)1.24975515
148Chronic hepatic failure (HP:0100626)1.24956749
149Hypodontia (HP:0000668)1.23081778
150Genetic anticipation (HP:0003743)1.21851798
151Renovascular hypertension (HP:0100817)1.21172105
152Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.21056245
153Degeneration of the lateral corticospinal tracts (HP:0002314)1.21056245
154Polycystic ovaries (HP:0000147)1.20851765
155Abnormality of saccadic eye movements (HP:0000570)1.19892924
156Microglossia (HP:0000171)1.17496411
157Sclerocornea (HP:0000647)1.14177290
158Asthma (HP:0002099)1.13884512
159Astigmatism (HP:0000483)1.13519122
160Retinitis pigmentosa (HP:0000510)1.12879573
161Preaxial hand polydactyly (HP:0001177)1.12782759
162Absent eyebrow (HP:0002223)1.12694048
163Abnormality of renal excretion (HP:0011036)1.12453307
164Abnormal drinking behavior (HP:0030082)1.11822029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.06909204
2PDK39.06909204
3PDK25.77425347
4TESK13.59985256
5ADRBK22.94173268
6MAP4K22.83902527
7TLK12.81266459
8WNK32.64150686
9PNCK2.60490695
10PRKD32.58671262
11ICK2.31377511
12STK392.29701520
13INSRR2.29618193
14ZAK2.26407509
15TNIK2.19585392
16WNK42.08658989
17PTK2B1.89425967
18MAPK151.87299751
19STK38L1.82065390
20ACVR1B1.74633180
21CASK1.73780222
22TAOK31.68660694
23OXSR11.66892579
24MAP3K41.53079759
25TXK1.45133690
26DYRK21.39307219
27NUAK11.37209728
28BCKDK1.35025992
29PLK41.34047843
30NEK21.20368085
31MKNK21.18909558
32TGFBR11.18474453
33IRAK11.17598724
34STK381.17336053
35CDK191.12028740
36MAP2K71.11764347
37PAK31.08359262
38PHKG11.07009308
39PHKG21.07009308
40CAMK1G1.02735950
41NTRK31.01635833
42ADRBK11.00781285
43VRK10.98436283
44PIK3CA0.95969321
45WNK10.94667423
46STK30.94606524
47EPHA40.94392568
48VRK20.91092629
49LMTK20.88965500
50WEE10.88822901
51FRK0.88685790
52CDK120.86378021
53STK240.83263239
54CSNK1G20.82038844
55EEF2K0.81756669
56ERBB30.81650968
57FGFR20.79471251
58BCR0.76794448
59CHEK20.76742975
60PRKCE0.76071767
61CSNK1G10.75058726
62MAP3K100.72827573
63CSNK1G30.72430915
64RPS6KA50.72276217
65PDK10.71626578
66BMPR20.70119419
67NME10.67933954
68TRIM280.67331157
69GRK10.66809569
70RIPK10.65897423
71PINK10.65608188
72DYRK1B0.64239801
73TTK0.63408936
74SIK20.62888151
75AKT30.62274601
76STK160.62120593
77TIE10.59706036
78BRSK20.59679881
79STK110.59118656
80CDC70.57048555
81CHEK10.53369109
82PRKACA0.52900821
83MKNK10.52681229
84MAPKAPK50.52336423
85DYRK1A0.51064003
86CAMK10.51003117
87IKBKB0.49688180
88MAP2K60.49029811
89CCNB10.48558737
90PRKCI0.48234214
91BRAF0.47911719
92ITK0.46431664
93PRPF4B0.46237811
94CSNK1A10.45416533
95CHUK0.45334453
96PASK0.45024458
97KIT0.44785327
98MAP2K20.44630918
99NEK60.44549910
100CAMKK10.43425169
101EPHB20.40993641
102DYRK30.40765992
103TEC0.40394077
104CSNK1A1L0.40133788
105DAPK20.39097312
106PRKCG0.38691823
107MAPKAPK30.38363605
108TYRO30.38328961
109ATR0.36735942
110ATM0.35458197
111SRPK10.34876798
112IRAK20.34511326
113OBSCN0.32547368
114RPS6KA60.32385567
115EIF2AK30.32339230
116MST40.31511952
117PLK10.31508290
118LATS10.30232233
119CAMK1D0.29621167
120NLK0.26268629
121BMPR1B0.25746146
122CAMKK20.25421470
123MARK10.24904620
124MUSK0.22933569
125NTRK20.22761557
126YES10.20459234
127BRSK10.20388809
128TESK20.20369296
129PAK10.19892852
130PBK0.16677511
131CDC42BPA0.13369543
132PRKAA10.12871509
133MTOR0.12773665
134PRKG10.11324191
135PDPK10.11240950
136PKN10.11100217
137AURKA0.10832184
138RPS6KB10.10444969
139MAPK130.10017930
140RPS6KA10.09379186
141CSNK2A10.08002025
142PRKDC0.06541078
143MAPK80.05988530
144CAMK2A0.05914351
145CSNK2A20.05825870
146CDK10.05159531
147PRKACG0.05029669
148CDK20.03807842
149CDK30.03670238
150RPS6KB20.03565171
151PRKCB0.03362266
152PLK20.02722682
153PLK30.02716121
154GSK3B0.02624212
155PRKG20.02602972
156MINK10.02139863
157PRKCZ0.01794963
158CSNK1D0.01062817
159PRKCA0.00911504
160PRKCQ0.00353306
161CDK150.00323593

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.81967811
2Pyruvate metabolism_Homo sapiens_hsa006203.70991668
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.55879288
4Oxidative phosphorylation_Homo sapiens_hsa001903.42094835
5Propanoate metabolism_Homo sapiens_hsa006403.36393338
6Basal transcription factors_Homo sapiens_hsa030223.27999786
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.98291208
8Parkinsons disease_Homo sapiens_hsa050122.82776035
9Fanconi anemia pathway_Homo sapiens_hsa034602.61399585
10Selenocompound metabolism_Homo sapiens_hsa004502.54147381
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.52398020
12Fatty acid biosynthesis_Homo sapiens_hsa000612.41358383
13Huntingtons disease_Homo sapiens_hsa050162.39046815
14Nitrogen metabolism_Homo sapiens_hsa009102.38900628
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36980633
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.30432151
17Olfactory transduction_Homo sapiens_hsa047402.27982989
18Glucagon signaling pathway_Homo sapiens_hsa049222.27172065
19Protein export_Homo sapiens_hsa030602.22965627
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17313180
21Pentose phosphate pathway_Homo sapiens_hsa000302.11038856
22Oocyte meiosis_Homo sapiens_hsa041142.01458855
23Ribosome_Homo sapiens_hsa030101.98460235
24Linoleic acid metabolism_Homo sapiens_hsa005911.96937138
25Butanoate metabolism_Homo sapiens_hsa006501.93843705
26Homologous recombination_Homo sapiens_hsa034401.93117390
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92340284
28Nicotine addiction_Homo sapiens_hsa050331.89847286
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83783546
30Alzheimers disease_Homo sapiens_hsa050101.82611192
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76956627
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76485800
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72044824
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71944572
35Tryptophan metabolism_Homo sapiens_hsa003801.67617499
36Caffeine metabolism_Homo sapiens_hsa002321.67490589
37Glycerolipid metabolism_Homo sapiens_hsa005611.65199655
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62743325
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62354728
40RNA polymerase_Homo sapiens_hsa030201.62232583
41Dorso-ventral axis formation_Homo sapiens_hsa043201.54109316
42ABC transporters_Homo sapiens_hsa020101.52702571
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42568723
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.42101704
45Peroxisome_Homo sapiens_hsa041461.41584799
46Mineral absorption_Homo sapiens_hsa049781.41306699
47Purine metabolism_Homo sapiens_hsa002301.36644897
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35972073
49PPAR signaling pathway_Homo sapiens_hsa033201.35968504
50Chemical carcinogenesis_Homo sapiens_hsa052041.34251198
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33172991
52Phototransduction_Homo sapiens_hsa047441.31398450
53Glutathione metabolism_Homo sapiens_hsa004801.31142771
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27925816
55Collecting duct acid secretion_Homo sapiens_hsa049661.25983572
56Carbon metabolism_Homo sapiens_hsa012001.23516928
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21971961
58Amphetamine addiction_Homo sapiens_hsa050311.21128661
59Morphine addiction_Homo sapiens_hsa050321.18615733
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17201140
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.15216614
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05601757
63N-Glycan biosynthesis_Homo sapiens_hsa005101.02507672
64RNA transport_Homo sapiens_hsa030131.00830607
65mRNA surveillance pathway_Homo sapiens_hsa030150.99945033
66One carbon pool by folate_Homo sapiens_hsa006700.99384744
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.98979759
68Synaptic vesicle cycle_Homo sapiens_hsa047210.98823759
69Renin secretion_Homo sapiens_hsa049240.98560214
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98139333
71Ether lipid metabolism_Homo sapiens_hsa005650.97099192
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.94865786
73Cardiac muscle contraction_Homo sapiens_hsa042600.90776951
74Regulation of autophagy_Homo sapiens_hsa041400.89399167
75Serotonergic synapse_Homo sapiens_hsa047260.88921640
76Taste transduction_Homo sapiens_hsa047420.88561156
77GABAergic synapse_Homo sapiens_hsa047270.87476364
78Ovarian steroidogenesis_Homo sapiens_hsa049130.87056622
79Proteasome_Homo sapiens_hsa030500.84425112
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83892061
81Inositol phosphate metabolism_Homo sapiens_hsa005620.80281331
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.78785506
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77783737
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77401293
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77329149
86Asthma_Homo sapiens_hsa053100.77215843
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77046055
88Biosynthesis of amino acids_Homo sapiens_hsa012300.69758379
89beta-Alanine metabolism_Homo sapiens_hsa004100.68886115
90Primary immunodeficiency_Homo sapiens_hsa053400.68432246
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67795889
92Arachidonic acid metabolism_Homo sapiens_hsa005900.66991580
93Retinol metabolism_Homo sapiens_hsa008300.66501547
94Calcium signaling pathway_Homo sapiens_hsa040200.66377512
95Basal cell carcinoma_Homo sapiens_hsa052170.66188528
96Pyrimidine metabolism_Homo sapiens_hsa002400.65691724
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64525378
98Fructose and mannose metabolism_Homo sapiens_hsa000510.64124624
99Type I diabetes mellitus_Homo sapiens_hsa049400.63206375
100Circadian entrainment_Homo sapiens_hsa047130.60978494
101Histidine metabolism_Homo sapiens_hsa003400.59740899
102Circadian rhythm_Homo sapiens_hsa047100.59373625
103Metabolic pathways_Homo sapiens_hsa011000.57946364
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56767990
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55615341
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54697786
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54076575
108Antigen processing and presentation_Homo sapiens_hsa046120.51744453
109Steroid biosynthesis_Homo sapiens_hsa001000.51345452
110Tight junction_Homo sapiens_hsa045300.51302656
111Long-term potentiation_Homo sapiens_hsa047200.50016638
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49138232
113Cocaine addiction_Homo sapiens_hsa050300.48904182
114Fatty acid degradation_Homo sapiens_hsa000710.48169823
115Renin-angiotensin system_Homo sapiens_hsa046140.47554784
116Insulin secretion_Homo sapiens_hsa049110.46775037
117Salivary secretion_Homo sapiens_hsa049700.45613998
118Systemic lupus erythematosus_Homo sapiens_hsa053220.45573002
119Fat digestion and absorption_Homo sapiens_hsa049750.45203035
120Fatty acid metabolism_Homo sapiens_hsa012120.43378363
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42260052
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41390956
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40809425
124Bile secretion_Homo sapiens_hsa049760.40468096
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.39763956
126Tyrosine metabolism_Homo sapiens_hsa003500.38436518
127Legionellosis_Homo sapiens_hsa051340.38212099
128Estrogen signaling pathway_Homo sapiens_hsa049150.37904922
129Rheumatoid arthritis_Homo sapiens_hsa053230.36207996
130Graft-versus-host disease_Homo sapiens_hsa053320.34312859
131Vitamin digestion and absorption_Homo sapiens_hsa049770.32583788
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32537219
133Mismatch repair_Homo sapiens_hsa034300.32370010
134Gastric acid secretion_Homo sapiens_hsa049710.31959700
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31771741
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30950076
137Sulfur relay system_Homo sapiens_hsa041220.30279807
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29375302
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28760444
140Cell cycle_Homo sapiens_hsa041100.28550914
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28493290
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25951930
143Sulfur metabolism_Homo sapiens_hsa009200.24776939
144cAMP signaling pathway_Homo sapiens_hsa040240.22850756
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22779690
146Protein digestion and absorption_Homo sapiens_hsa049740.22124216
147Glutamatergic synapse_Homo sapiens_hsa047240.20544382
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19775607
149Dopaminergic synapse_Homo sapiens_hsa047280.19151218
150Thyroid hormone synthesis_Homo sapiens_hsa049180.17102469
151RNA degradation_Homo sapiens_hsa030180.16560265
152Nucleotide excision repair_Homo sapiens_hsa034200.16203269
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13925087
154Hedgehog signaling pathway_Homo sapiens_hsa043400.13533345
155Alcoholism_Homo sapiens_hsa050340.13530659

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