DYDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.94701914
2epithelial cilium movement (GO:0003351)9.60357470
3cilium or flagellum-dependent cell motility (GO:0001539)9.22847515
4cell wall macromolecule metabolic process (GO:0044036)9.22640717
5cell wall macromolecule catabolic process (GO:0016998)9.22640717
6acrosome reaction (GO:0007340)8.37469439
7fusion of sperm to egg plasma membrane (GO:0007342)8.27718733
8sperm-egg recognition (GO:0035036)7.44857011
9negative regulation of inclusion body assembly (GO:0090084)7.37974000
10spermatid development (GO:0007286)7.31028200
11multicellular organism reproduction (GO:0032504)7.20203078
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.16309828
13binding of sperm to zona pellucida (GO:0007339)7.07201609
14regulation of cilium movement (GO:0003352)6.90095820
15acrosome assembly (GO:0001675)6.80837368
16cell-cell recognition (GO:0009988)6.59876128
17reproduction (GO:0000003)6.39153712
18spermatid nucleus differentiation (GO:0007289)6.39048164
19ventricular system development (GO:0021591)6.24159795
20plasma membrane fusion (GO:0045026)6.21686254
21primary alcohol catabolic process (GO:0034310)6.12257660
22axoneme assembly (GO:0035082)6.00571626
23synaptonemal complex organization (GO:0070193)5.71852314
24microtubule severing (GO:0051013)5.69611795
25microtubule depolymerization (GO:0007019)5.57599521
26regulation of inclusion body assembly (GO:0090083)5.55890574
27vitamin transmembrane transport (GO:0035461)5.34706056
28GTP biosynthetic process (GO:0006183)5.27358048
29synaptonemal complex assembly (GO:0007130)5.24449794
30diterpenoid biosynthetic process (GO:0016102)5.20471724
31spermatogenesis (GO:0007283)5.15074801
32male gamete generation (GO:0048232)5.13327040
33piRNA metabolic process (GO:0034587)5.11140217
34male meiosis (GO:0007140)5.06080218
35single fertilization (GO:0007338)5.03236145
36ethanol metabolic process (GO:0006067)5.02275672
37gamete generation (GO:0007276)4.75916487
38DNA damage response, detection of DNA damage (GO:0042769)4.73682504
39nucleoside diphosphate phosphorylation (GO:0006165)4.69521983
40UTP biosynthetic process (GO:0006228)4.67405353
41guanosine-containing compound biosynthetic process (GO:1901070)4.53612463
42organic cation transport (GO:0015695)4.49128850
43one-carbon compound transport (GO:0019755)4.41782734
44cell projection assembly (GO:0030031)4.28225722
45single strand break repair (GO:0000012)4.28138976
46fertilization (GO:0009566)4.23737775
47calcium ion-dependent exocytosis (GO:0017156)4.19804827
48sperm capacitation (GO:0048240)4.19618750
49C21-steroid hormone biosynthetic process (GO:0006700)4.17408151
50response to xenobiotic stimulus (GO:0009410)4.16850067
51UTP metabolic process (GO:0046051)4.16816223
52intraciliary transport (GO:0042073)4.15129777
53protein refolding (GO:0042026)4.14999877
54pyrimidine-containing compound transmembrane transport (GO:0072531)4.09819589
55lung epithelium development (GO:0060428)4.09599040
56negative regulation of T cell differentiation in thymus (GO:0033085)4.08775394
57negative regulation of JUN kinase activity (GO:0043508)4.06558874
58male meiosis I (GO:0007141)4.02237834
59regulation of microtubule-based movement (GO:0060632)4.01381550
60terpenoid biosynthetic process (GO:0016114)3.99631219
61retinoic acid metabolic process (GO:0042573)3.94835170
62microtubule bundle formation (GO:0001578)3.94281129
63ethanol oxidation (GO:0006069)3.91552989
64cellular glucuronidation (GO:0052695)3.90271256
65retinal rod cell development (GO:0046548)3.89268034
66centriole replication (GO:0007099)3.82639189
67germ cell development (GO:0007281)3.78849557
68intra-S DNA damage checkpoint (GO:0031573)3.78007599
69cilium organization (GO:0044782)3.69491725
70multicellular organismal reproductive process (GO:0048609)3.68108893
71left/right axis specification (GO:0070986)3.67213403
72progesterone metabolic process (GO:0042448)3.66059807
73chromosome condensation (GO:0030261)3.64189027
74cellular process involved in reproduction in multicellular organism (GO:0022412)3.63625414
75cilium morphogenesis (GO:0060271)3.60403388
76meiosis I (GO:0007127)3.60214769
77cilium assembly (GO:0042384)3.59017309
78protein polyglutamylation (GO:0018095)3.58828010
79exogenous drug catabolic process (GO:0042738)3.56715131
80regulation of type B pancreatic cell apoptotic process (GO:2000674)3.56674975
81interleukin-6-mediated signaling pathway (GO:0070102)3.56636545
82sexual reproduction (GO:0019953)3.55480931
83determination of left/right symmetry (GO:0007368)3.52874051
84protein K11-linked deubiquitination (GO:0035871)3.52852794
85lateral ventricle development (GO:0021670)3.51813986
86microtubule-based movement (GO:0007018)3.49796469
87glucuronate metabolic process (GO:0019585)3.49664480
88uronic acid metabolic process (GO:0006063)3.49664480
89smoothened signaling pathway (GO:0007224)3.49170167
90glomerular epithelial cell development (GO:0072310)3.45735549
91left/right pattern formation (GO:0060972)3.45468450
92tolerance induction (GO:0002507)3.44957888
93regulation of transmission of nerve impulse (GO:0051969)3.44114294
94response to insecticide (GO:0017085)3.43452840
95DNA packaging (GO:0006323)3.42144521
96establishment of apical/basal cell polarity (GO:0035089)3.36364886
97determination of bilateral symmetry (GO:0009855)3.35346541
98microtubule polymerization or depolymerization (GO:0031109)3.34669030
99glutathione derivative metabolic process (GO:1901685)3.32784734
100glutathione derivative biosynthetic process (GO:1901687)3.32784734
101negative regulation of B cell mediated immunity (GO:0002713)3.32203058
102negative regulation of immunoglobulin mediated immune response (GO:0002890)3.32203058
103retinal cone cell development (GO:0046549)3.29697209
104specification of symmetry (GO:0009799)3.28835611
105establishment or maintenance of monopolar cell polarity (GO:0061339)3.28431753
106establishment of monopolar cell polarity (GO:0061162)3.28431753
107meiotic nuclear division (GO:0007126)3.25061823
108cellular component assembly involved in morphogenesis (GO:0010927)3.24911910
109CTP metabolic process (GO:0046036)3.21952313
110CTP biosynthetic process (GO:0006241)3.21952313
111positive regulation of neurological system process (GO:0031646)3.20611270
112cytoplasmic microtubule organization (GO:0031122)3.19735299
113cell recognition (GO:0008037)3.17545262
114negative regulation of humoral immune response (GO:0002921)3.16474817
115lateral sprouting from an epithelium (GO:0060601)3.14436069
116chromosome organization involved in meiosis (GO:0070192)3.13186768
117sequestering of actin monomers (GO:0042989)3.12749590
118DNA methylation involved in gamete generation (GO:0043046)3.11136867
119CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.11055931
120protein localization to cilium (GO:0061512)3.11026208
121dopamine biosynthetic process (GO:0042416)3.09466475
122regulation of interleukin-5 production (GO:0032674)3.06668644
123regulation of spindle checkpoint (GO:0090231)3.00113921
124glycerol ether metabolic process (GO:0006662)2.95459447
125aldehyde catabolic process (GO:0046185)2.94693185
126pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.91680719
127polyamine biosynthetic process (GO:0006596)2.91650335
128photoreceptor cell maintenance (GO:0045494)2.90427131
129retinol metabolic process (GO:0042572)2.90095175
130primary alcohol metabolic process (GO:0034308)2.84234827
131drug catabolic process (GO:0042737)2.83153769
132microtubule-based process (GO:0007017)2.83112613
133nucleotide transmembrane transport (GO:1901679)2.79825996
134ventricular cardiac muscle cell development (GO:0055015)2.78932701
135centriole assembly (GO:0098534)2.78446749
136meiotic cell cycle (GO:0051321)2.78398293
137organelle assembly (GO:0070925)2.77548261
138regulation of T-helper 2 cell differentiation (GO:0045628)2.77473073
139regulation of collateral sprouting (GO:0048670)2.77164144
140regulation of germinal center formation (GO:0002634)2.77100479
141positive regulation of smoothened signaling pathway (GO:0045880)2.75529399
142nucleus organization (GO:0006997)2.70964693
143establishment of tissue polarity (GO:0007164)2.69404923
144establishment of planar polarity (GO:0001736)2.69404923
145nonmotile primary cilium assembly (GO:0035058)2.60612175
146O-glycan processing (GO:0016266)2.56624266
147hydrogen peroxide biosynthetic process (GO:0050665)2.50912363
148positive regulation of tolerance induction (GO:0002645)2.48242613
149phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.47816667
150regulation of interleukin-13 production (GO:0032656)2.45586215
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42510457
152excretion (GO:0007588)2.37510882
153regulation of smoothened signaling pathway (GO:0008589)2.35590496
154neural tube formation (GO:0001841)2.35144857
155heart looping (GO:0001947)2.32477169
156regulation of microtubule depolymerization (GO:0031114)2.31113612
157carnitine metabolic process (GO:0009437)2.30308455
158reactive oxygen species biosynthetic process (GO:1903409)2.29786157
159spinal cord motor neuron differentiation (GO:0021522)2.27453073
160regulation of secondary heart field cardioblast proliferation (GO:0003266)2.23073314
161regulation of cardioblast proliferation (GO:0003264)2.23073314
162regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.20994575
163phosphatidylcholine biosynthetic process (GO:0006656)2.18017887
164sodium ion homeostasis (GO:0055078)2.17497378
165axonemal dynein complex assembly (GO:0070286)12.4605484
166sperm motility (GO:0030317)11.1097694
167cilium movement (GO:0003341)10.6755699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.80042326
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.96825198
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.95342415
4VDR_22108803_ChIP-Seq_LS180_Human3.77139639
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.50985532
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14646332
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.73609865
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.53356020
9ZNF274_21170338_ChIP-Seq_K562_Hela2.42466601
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.40766800
11DROSHA_22980978_ChIP-Seq_HELA_Human2.37519590
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.25756119
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.24815481
14EZH2_22144423_ChIP-Seq_EOC_Human2.24325536
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13178049
16FUS_26573619_Chip-Seq_HEK293_Human2.05081899
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00123253
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99154131
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.92966678
20* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89755412
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.86861520
22AR_21572438_ChIP-Seq_LNCaP_Human1.83453495
23TOP2B_26459242_ChIP-Seq_MCF-7_Human1.83070510
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80049210
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74234500
26SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.73842993
27* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.73780730
28GBX2_23144817_ChIP-Seq_PC3_Human1.71613805
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71026847
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70967561
31TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70311095
32SMAD4_21799915_ChIP-Seq_A2780_Human1.69451870
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68373411
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68239231
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64197737
36TAL1_26923725_Chip-Seq_HPCs_Mouse1.63833297
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58598924
38BCAT_22108803_ChIP-Seq_LS180_Human1.57295596
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.52935691
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51512693
41TCF4_22108803_ChIP-Seq_LS180_Human1.50722959
42PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.49875791
43PHF8_20622853_ChIP-Seq_HELA_Human1.49469289
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48369918
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47540827
46P300_19829295_ChIP-Seq_ESCs_Human1.47491715
47EWS_26573619_Chip-Seq_HEK293_Human1.47106578
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46271449
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44301361
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43301172
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41957611
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.41601881
53STAT3_23295773_ChIP-Seq_U87_Human1.41092487
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39389320
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38817928
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.37937590
57LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36700221
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.36134480
59RNF2_27304074_Chip-Seq_NSC_Mouse1.35783126
60FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35403965
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.34194865
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34194865
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34050396
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33385006
65STAT1_17558387_ChIP-Seq_HELA_Human1.33357289
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33225581
67ER_23166858_ChIP-Seq_MCF-7_Human1.33178919
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33061839
69RBPJ_21746931_ChIP-Seq_IB4_Human1.32043381
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.31858500
71CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31712197
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.31670033
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.31398844
74CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31343515
75TP53_18474530_ChIP-ChIP_U2OS_Human1.30321407
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28992673
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27755351
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27046397
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26427233
80NFYA_21822215_ChIP-Seq_K562_Human1.26305432
81GF1_26923725_Chip-Seq_HPCs_Mouse1.25915556
82TCF4_23295773_ChIP-Seq_U87_Human1.25354775
83CBX2_22325352_ChIP-Seq_293T-Rex_Human1.25088505
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22819960
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21340076
86CBP_20019798_ChIP-Seq_JUKART_Human1.21181211
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21181211
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21002128
89AR_20517297_ChIP-Seq_VCAP_Human1.19865486
90TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19535726
91RUNX2_22187159_ChIP-Seq_PCA_Human1.18169291
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18103610
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.17793747
94TP63_23658742_ChIP-Seq_EP156T_Human1.17694477
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17511767
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.17224721
97P53_21459846_ChIP-Seq_SAOS-2_Human1.16522497
98REST_21632747_ChIP-Seq_MESCs_Mouse1.13059549
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.12819094
100TP53_16413492_ChIP-PET_HCT116_Human1.12811512
101RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12007138
102NANOG_19829295_ChIP-Seq_ESCs_Human1.11771839
103SOX2_19829295_ChIP-Seq_ESCs_Human1.11771839
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11620118
105KDM2B_26808549_Chip-Seq_REH_Human1.11582100
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11232583
107CDX2_22108803_ChIP-Seq_LS180_Human1.10537799
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10210430
109IGF1R_20145208_ChIP-Seq_DFB_Human1.10168879
110SMRT_27268052_Chip-Seq_Bcells_Human1.09322146
111AR_25329375_ChIP-Seq_VCAP_Human1.09139128
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08971697
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08690104
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08690104
115FOXA1_25552417_ChIP-Seq_VCAP_Human1.08339021
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07761298
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07382994
118ERG_20517297_ChIP-Seq_VCAP_Human1.06629814
119STAT1_20625510_ChIP-Seq_HELA_Human1.05673353
120SPI1_26923725_Chip-Seq_HPCs_Mouse1.04795762
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.04332057
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03810540
123* GATA6_21074721_ChIP-Seq_CACO-2_Human1.03331929
124* SOX9_26525672_Chip-Seq_HEART_Mouse1.02613799
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02398466
126GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02332976
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.02238620
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01355693
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01276818
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01186894
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00520520
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00327600
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.00253016
134TBL1_22424771_ChIP-Seq_293T_Human0.99899378
135MYC_19829295_ChIP-Seq_ESCs_Human0.99863120
136CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99291708
137NCOR_22424771_ChIP-Seq_293T_Human0.99200803
138LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98968991
139P53_22387025_ChIP-Seq_ESCs_Mouse0.98666645
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.98593267
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97344846
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96992323
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96967747
144TAF15_26573619_Chip-Seq_HEK293_Human0.96861770
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96268945
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.94995644
147EZH2_27294783_Chip-Seq_ESCs_Mouse0.94559431
148FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94012392
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.93151189
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92357266
151GATA3_21867929_ChIP-Seq_TH1_Mouse0.92326696
152SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92112745
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91682432
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.91305606
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.91238238
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91075834
157ETV1_20927104_ChIP-Seq_GIST48_Human0.90694182
158RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90637685
159NFYB_21822215_ChIP-Seq_K562_Human0.90261415
160E2F1_18555785_Chip-Seq_ESCs_Mouse0.90260718
161AHR_22903824_ChIP-Seq_MCF-7_Human0.89102644
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.89001449
163FLI1_21867929_ChIP-Seq_CD8_Mouse0.88903799
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.88863946
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.88442030
166* FOXH1_21741376_ChIP-Seq_ESCs_Human0.86504123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.95662055
2MP0005377_hearing/vestibular/ear_phenot4.22903478
3MP0003878_abnormal_ear_physiology4.22903478
4MP0003698_abnormal_male_reproductive4.13462977
5MP0001929_abnormal_gametogenesis4.03652872
6MP0008004_abnormal_stomach_pH4.02134853
7MP0004043_abnormal_pH_regulation3.13317130
8MP0002277_abnormal_respiratory_mucosa3.01640801
9MP0002210_abnormal_sex_determination2.97642606
10MP0002160_abnormal_reproductive_system2.87880651
11MP0000566_synostosis2.71974604
12MP0002161_abnormal_fertility/fecundity2.45296321
13MP0002282_abnormal_trachea_morphology2.36494366
14MP0001905_abnormal_dopamine_level2.34176591
15MP0001145_abnormal_male_reproductive2.30537564
16MP0000653_abnormal_sex_gland2.28457111
17MP0000383_abnormal_hair_follicle2.26648912
18MP0008877_abnormal_DNA_methylation2.24169587
19MP0003136_yellow_coat_color2.13596632
20MP0001984_abnormal_olfaction2.10142537
21MP0005647_abnormal_sex_gland2.07393526
22MP0002734_abnormal_mechanical_nocicepti2.04315312
23MP0010030_abnormal_orbit_morphology2.02634367
24MP0009780_abnormal_chondrocyte_physiolo2.02016473
25MP0002653_abnormal_ependyma_morphology1.95660044
26MP0008789_abnormal_olfactory_epithelium1.93167320
27MP0005670_abnormal_white_adipose1.86197186
28MP0001501_abnormal_sleep_pattern1.84399742
29MP0001485_abnormal_pinna_reflex1.80690169
30MP0004019_abnormal_vitamin_homeostasis1.72227434
31MP0005394_taste/olfaction_phenotype1.66454718
32MP0005499_abnormal_olfactory_system1.66454718
33MP0008057_abnormal_DNA_replication1.64669756
34MP0005389_reproductive_system_phenotype1.60755255
35MP0003718_maternal_effect1.60061671
36MP0005551_abnormal_eye_electrophysiolog1.58939286
37MP0010678_abnormal_skin_adnexa1.58192971
38MP0001293_anophthalmia1.48774128
39MP0003880_abnormal_central_pattern1.47412550
40MP0005253_abnormal_eye_physiology1.46205281
41MP0004134_abnormal_chest_morphology1.44385182
42MP0005083_abnormal_biliary_tract1.40489289
43MP0003890_abnormal_embryonic-extraembry1.38145159
44MP0004885_abnormal_endolymph1.26920109
45MP0005084_abnormal_gallbladder_morpholo1.26725980
46MP0000613_abnormal_salivary_gland1.26599963
47MP0002233_abnormal_nose_morphology1.26266289
48MP0003786_premature_aging1.25862524
49MP0010368_abnormal_lymphatic_system1.25255533
50MP0009379_abnormal_foot_pigmentation1.23952733
51MP0008875_abnormal_xenobiotic_pharmacok1.23280404
52MP0004270_analgesia1.22187781
53MP0006072_abnormal_retinal_apoptosis1.21627798
54MP0000026_abnormal_inner_ear1.20238990
55MP0002928_abnormal_bile_duct1.19612977
56MP0001764_abnormal_homeostasis1.19331308
57MP0000631_abnormal_neuroendocrine_gland1.19122259
58MP0002638_abnormal_pupillary_reflex1.18696698
59MP0003123_paternal_imprinting1.14340014
60MP0008058_abnormal_DNA_repair1.14328133
61MP0005623_abnormal_meninges_morphology1.09462322
62MP0003186_abnormal_redox_activity1.09201620
63MP0001177_atelectasis1.07850367
64MP0002736_abnormal_nociception_after1.07751590
65MP0001346_abnormal_lacrimal_gland1.06626096
66MP0002332_abnormal_exercise_endurance1.04278613
67MP0005195_abnormal_posterior_eye0.99915449
68MP0005646_abnormal_pituitary_gland0.99417837
69MP0003942_abnormal_urinary_system0.99408783
70MP0002909_abnormal_adrenal_gland0.97917402
71MP0002249_abnormal_larynx_morphology0.96792784
72MP0004133_heterotaxia0.93284552
73MP0005391_vision/eye_phenotype0.92962168
74MP0001324_abnormal_eye_pigmentation0.91758023
75MP0003937_abnormal_limbs/digits/tail_de0.91026716
76MP0000534_abnormal_ureter_morphology0.90634898
77MP0002735_abnormal_chemical_nociception0.89555131
78MP0005636_abnormal_mineral_homeostasis0.89144499
79MP0003195_calcinosis0.85841251
80MP0004811_abnormal_neuron_physiology0.85084156
81MP0005085_abnormal_gallbladder_physiolo0.84442977
82MP0003633_abnormal_nervous_system0.84008306
83MP0009250_abnormal_appendicular_skeleto0.83024918
84MP0001968_abnormal_touch/_nociception0.82870737
85MP0005187_abnormal_penis_morphology0.82174718
86MP0004381_abnormal_hair_follicle0.81990797
87MP0002102_abnormal_ear_morphology0.81428171
88MP0005408_hypopigmentation0.80820992
89MP0002168_other_aberrant_phenotype0.76489129
90MP0000955_abnormal_spinal_cord0.76222478
91MP0002876_abnormal_thyroid_physiology0.76051589
92MP0003656_abnormal_erythrocyte_physiolo0.75397361
93MP0004147_increased_porphyrin_level0.75251231
94MP0003111_abnormal_nucleus_morphology0.74192503
95MP0005257_abnormal_intraocular_pressure0.74125200
96MP0002938_white_spotting0.73799577
97MP0002557_abnormal_social/conspecific_i0.73645079
98MP0001970_abnormal_pain_threshold0.73211905
99MP0002229_neurodegeneration0.72913096
100MP0006292_abnormal_olfactory_placode0.71850922
101MP0006276_abnormal_autonomic_nervous0.71693870
102MP0001486_abnormal_startle_reflex0.71441696
103MP0002234_abnormal_pharynx_morphology0.71366353
104MP0005365_abnormal_bile_salt0.71272548
105MP0003693_abnormal_embryo_hatching0.70749717
106MP0005379_endocrine/exocrine_gland_phen0.69852730
107MP0000778_abnormal_nervous_system0.68448382
108MP0001765_abnormal_ion_homeostasis0.68306109
109MP0002572_abnormal_emotion/affect_behav0.67972493
110MP0003115_abnormal_respiratory_system0.67893824
111MP0001529_abnormal_vocalization0.67295013
112MP0003861_abnormal_nervous_system0.67150113
113MP0005266_abnormal_metabolism0.67047243
114MP0000762_abnormal_tongue_morphology0.66180366
115MP0009745_abnormal_behavioral_response0.65971924
116MP0006082_CNS_inflammation0.65642535
117MP0003699_abnormal_female_reproductive0.65506102
118MP0001286_abnormal_eye_development0.64859747
119MP0001188_hyperpigmentation0.63835746
120MP0005395_other_phenotype0.62455044
121MP0004142_abnormal_muscle_tone0.62087704
122MP0005248_abnormal_Harderian_gland0.61898792
123MP0003631_nervous_system_phenotype0.61843233
124MP0000678_abnormal_parathyroid_gland0.59454100
125MP0002272_abnormal_nervous_system0.58175893
126MP0000467_abnormal_esophagus_morphology0.58139159
127MP0001119_abnormal_female_reproductive0.58061317
128MP0003936_abnormal_reproductive_system0.58046624
129MP0002132_abnormal_respiratory_system0.57865606
130MP0003943_abnormal_hepatobiliary_system0.57714263
131MP0004859_abnormal_synaptic_plasticity0.57201436
132MP0002163_abnormal_gland_morphology0.56379753
133MP0008872_abnormal_physiological_respon0.55860056
134MP0000049_abnormal_middle_ear0.55540119
135MP0009384_cardiac_valve_regurgitation0.54053903
136MP0008260_abnormal_autophagy0.53986483
137MP0002877_abnormal_melanocyte_morpholog0.53545565
138MP0009046_muscle_twitch0.52705496
139MP0002184_abnormal_innervation0.52457027
140MP0001542_abnormal_bone_strength0.50359878
141MP0001270_distended_abdomen0.50033143
142MP0002752_abnormal_somatic_nervous0.49956448
143MP0003279_aneurysm0.49887703
144MP0003938_abnormal_ear_development0.49723820
145MP0003011_delayed_dark_adaptation0.49094202
146MP0003690_abnormal_glial_cell0.49076062
147MP0001963_abnormal_hearing_physiology0.48712989
148MP0001502_abnormal_circadian_rhythm0.46797290
149MP0008995_early_reproductive_senescence0.46130398
150MP0002269_muscular_atrophy0.46093626
151MP0003879_abnormal_hair_cell0.45795357
152MP0004883_abnormal_blood_vessel0.45605841
153MP0000372_irregular_coat_pigmentation0.45431330

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.52592222
2Absent/shortened dynein arms (HP:0200106)9.52592222
3Abnormal ciliary motility (HP:0012262)9.35963700
4Abnormal respiratory motile cilium morphology (HP:0005938)9.21969624
5Abnormal respiratory epithelium morphology (HP:0012253)9.21969624
6Rhinitis (HP:0012384)8.04065982
7Male infertility (HP:0003251)6.88834644
8Chronic bronchitis (HP:0004469)6.11293477
9Infertility (HP:0000789)5.85593799
10Nasal polyposis (HP:0100582)4.67582604
11Bronchiectasis (HP:0002110)4.50659316
12Urethral obstruction (HP:0000796)4.29784384
13Abnormality of the nasal mucosa (HP:0000433)3.71957880
14Chronic hepatic failure (HP:0100626)3.47083873
15Pancreatic fibrosis (HP:0100732)3.31142942
16Tubulointerstitial nephritis (HP:0001970)3.27211514
17Short nail (HP:0001799)3.26554182
18True hermaphroditism (HP:0010459)3.05645031
19Medial flaring of the eyebrow (HP:0010747)3.04379515
20Supernumerary spleens (HP:0009799)3.00760684
21Occipital encephalocele (HP:0002085)2.97340771
22Bile duct proliferation (HP:0001408)2.97122265
23Abnormal biliary tract physiology (HP:0012439)2.97122265
24Chronic otitis media (HP:0000389)2.86133034
25Bronchitis (HP:0012387)2.79341509
26Genetic anticipation (HP:0003743)2.77005378
27Chronic sinusitis (HP:0011109)2.65226897
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.55479966
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55479966
30Hyperactive renin-angiotensin system (HP:0000841)2.53229082
31Broad distal phalanx of finger (HP:0009836)2.47368085
32Natal tooth (HP:0000695)2.41050426
33Nephronophthisis (HP:0000090)2.39672332
34Tubular atrophy (HP:0000092)2.36288401
35Gait imbalance (HP:0002141)2.34788682
36Atelectasis (HP:0100750)2.34131869
37Anencephaly (HP:0002323)2.34129367
38Pancreatic cysts (HP:0001737)2.33208496
39Congenital primary aphakia (HP:0007707)2.30701354
40Cystic liver disease (HP:0006706)2.28388459
41Abnormality of dentin (HP:0010299)2.27531935
42Abnormality of permanent molar morphology (HP:0011071)2.22232209
43Abnormality of the dental root (HP:0006486)2.22232209
44Taurodontia (HP:0000679)2.22232209
45Adrenal hypoplasia (HP:0000835)2.21667573
46Postaxial foot polydactyly (HP:0001830)2.19797645
47Abnormality of the umbilical cord (HP:0010881)2.19702377
48Male pseudohermaphroditism (HP:0000037)2.16790196
49Insidious onset (HP:0003587)2.11474294
50Termporal pattern (HP:0011008)2.11474294
51Recurrent otitis media (HP:0000403)2.11262491
52Abnormality of molar (HP:0011077)2.06066710
53Abnormality of molar morphology (HP:0011070)2.06066710
54Abnormality of the corticospinal tract (HP:0002492)2.04423165
55Nephrogenic diabetes insipidus (HP:0009806)2.04411793
56Recurrent sinusitis (HP:0011108)2.03909886
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4820450
58Abnormal respiratory motile cilium physiology (HP:0012261)10.1533369
59Abnormality of the dental pulp (HP:0006479)1.98944945
60Oral leukoplakia (HP:0002745)1.96546231
61Molar tooth sign on MRI (HP:0002419)1.95568763
62Abnormality of midbrain morphology (HP:0002418)1.95568763
63Abnormality of the fetal cardiovascular system (HP:0010948)1.94532152
64Abnormal umbilical cord blood vessels (HP:0011403)1.94532152
65Single umbilical artery (HP:0001195)1.94532152
66Tubulointerstitial abnormality (HP:0001969)1.89976197
67Hydroureter (HP:0000072)1.89599610
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.88064129
69Bell-shaped thorax (HP:0001591)1.87659151
70Abnormal tarsal ossification (HP:0008369)1.87272502
71Asplenia (HP:0001746)1.85830916
72Abnormal spermatogenesis (HP:0008669)1.82236235
73Urinary bladder sphincter dysfunction (HP:0002839)1.82152394
74Aplasia involving bones of the upper limbs (HP:0009823)1.81554524
75Aplasia of the phalanges of the hand (HP:0009802)1.81554524
76Aplasia involving bones of the extremities (HP:0009825)1.81554524
77Poor coordination (HP:0002370)1.81396618
78Aplasia/Hypoplasia of the lens (HP:0008063)1.77300539
79Decreased circulating renin level (HP:0003351)1.76251903
80Shoulder girdle muscle weakness (HP:0003547)1.74186350
81Breech presentation (HP:0001623)1.74122623
82Congenital hepatic fibrosis (HP:0002612)1.73780690
83Renal salt wasting (HP:0000127)1.73395300
84Fibular hypoplasia (HP:0003038)1.72373112
85Preaxial hand polydactyly (HP:0001177)1.70557908
86Recurrent bronchitis (HP:0002837)1.70466600
87Vaginal atresia (HP:0000148)1.70211486
88Impulsivity (HP:0100710)1.70114438
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69818404
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.69608471
91Upper limb muscle weakness (HP:0003484)1.68051785
92Genital tract atresia (HP:0001827)1.67451025
93Abnormality of the renal medulla (HP:0100957)1.67447904
94Submucous cleft hard palate (HP:0000176)1.66238536
95Ventricular fibrillation (HP:0001663)1.63957444
96Nephropathy (HP:0000112)1.63653414
97Median cleft lip (HP:0000161)1.60289023
98Stillbirth (HP:0003826)1.57931714
99Peripheral hypomyelination (HP:0007182)1.56640551
100Polydipsia (HP:0001959)1.56487720
101Abnormal drinking behavior (HP:0030082)1.56487720
102Abnormality of the renal cortex (HP:0011035)1.54607230
103Decreased central vision (HP:0007663)1.52299275
104Hyperglycinuria (HP:0003108)1.51297460
105Bundle branch block (HP:0011710)1.46320185
106Sclerocornea (HP:0000647)1.45364893
107Stage 5 chronic kidney disease (HP:0003774)1.44616307
108Abnormal rod and cone electroretinograms (HP:0008323)1.44555805
109Postaxial hand polydactyly (HP:0001162)1.41869475
110Hyperaldosteronism (HP:0000859)1.41546789
111Gaze-evoked nystagmus (HP:0000640)1.41199355
112Oculomotor apraxia (HP:0000657)1.38226793
113Furrowed tongue (HP:0000221)1.37669608
114Anophthalmia (HP:0000528)1.36680287
115Rimmed vacuoles (HP:0003805)1.36459172
116Facial cleft (HP:0002006)1.36284218
117Rough bone trabeculation (HP:0100670)1.35718979
118Azoospermia (HP:0000027)1.35627662
119Down-sloping shoulders (HP:0200021)1.34383219
120Flat acetabular roof (HP:0003180)1.34359548
121Abnormality of renin-angiotensin system (HP:0000847)1.33134562
122Dysmetric saccades (HP:0000641)1.32059998
123Morphological abnormality of the pyramidal tract (HP:0002062)1.31679875
124Hypokalemic alkalosis (HP:0001949)1.27985674
125Absent frontal sinuses (HP:0002688)1.25851309
126Narrow forehead (HP:0000341)1.24853729
127Hyperkalemia (HP:0002153)1.23095681
128Bifid scrotum (HP:0000048)1.21278156
129Tubulointerstitial fibrosis (HP:0005576)1.19804202
130Aganglionic megacolon (HP:0002251)1.18563614
131Retinitis pigmentosa (HP:0000510)1.17333332
132Abnormality of chloride homeostasis (HP:0011422)1.15782695
133Prominent nasal bridge (HP:0000426)1.12453753
134Multicystic kidney dysplasia (HP:0000003)1.10237870
135Polyuria (HP:0000103)1.09992393
136Optic nerve coloboma (HP:0000588)1.09960981
137Hip dysplasia (HP:0001385)1.08469056
138Abnormality of macular pigmentation (HP:0008002)1.07719744
139Renal dysplasia (HP:0000110)1.07081801
140Cone-rod dystrophy (HP:0000548)1.06689493
141Holoprosencephaly (HP:0001360)1.06006640
142Short thorax (HP:0010306)1.05730093
143Broad foot (HP:0001769)1.04752043
144Abnormality of renal excretion (HP:0011036)1.04687775
145Specific learning disability (HP:0001328)1.04393779
146Highly arched eyebrow (HP:0002553)0.98899816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.22879935
2PDK46.22879935
3TESK14.38513957
4PDK23.96609771
5PNCK3.28452047
6PRKD33.18041270
7FRK2.74534255
8EPHA22.56942439
9MAP4K22.25460653
10PINK11.98037239
11STK391.96940069
12WEE11.89533184
13PTK2B1.87413681
14ARAF1.85650113
15ICK1.79433567
16MAPK151.76530340
17NME11.75391718
18BUB11.73100695
19GRK11.67810865
20MAPKAPK51.61362050
21EEF2K1.58764931
22MAPKAPK31.58347628
23WNK41.54259034
24PLK41.52086954
25VRK11.47364032
26STK381.43678426
27INSRR1.40439267
28WNK31.39685734
29BMPR1B1.37342684
30BRSK21.36826766
31LATS11.33803850
32WNK11.31432194
33NEK61.29597289
34PBK1.26938840
35TLK11.26084129
36LIMK11.24136311
37NUAK11.23850970
38STK38L1.23448013
39STK241.19071494
40PRKCG1.17629459
41MAP3K41.14098484
42LATS21.12920664
43ZAK1.11807802
44MAP3K91.10816222
45ERBB31.02357327
46TNK21.01173950
47TNIK1.01090268
48TSSK60.97917275
49ADRBK20.97057438
50MAP2K60.91775348
51TTK0.90928481
52EPHA40.90630224
53OXSR10.90467621
54CSNK1G30.90370113
55BMPR20.89277042
56CDC42BPA0.86533793
57MAP2K40.85507814
58BRSK10.84784519
59MAP3K20.82437848
60BRAF0.79681422
61LMTK20.76341403
62PLK30.76163073
63PIM20.74428485
64ACVR1B0.73209175
65MAP2K70.70643723
66CHEK20.70207253
67CSNK1A1L0.68841446
68CDK30.68094234
69ADRBK10.67878384
70ERBB20.67183608
71CDK190.66463891
72MINK10.66286455
73NEK20.65747645
74CSNK1G20.65646381
75AURKA0.62883354
76STK100.61842119
77TRIM280.61809507
78RPS6KB20.60288518
79DYRK30.59342895
80MAP2K30.58179001
81PDK10.55300787
82DAPK20.54752244
83CSNK1G10.54371362
84MARK10.54088043
85MUSK0.53297601
86CAMKK10.53108220
87NTRK30.52910079
88MKNK20.51930386
89HIPK20.50904851
90GRK50.50130540
91EIF2AK30.49622682
92PLK10.48975606
93BCR0.47867774
94CHEK10.46979439
95TRPM70.46704390
96MAP3K120.45504878
97MAP3K70.44650665
98RIPK40.44542278
99LRRK20.44317289
100DYRK1A0.44286794
101NTRK10.43838045
102MAP3K30.42204277
103DYRK1B0.42127737
104CSK0.40563373
105CAMK1G0.40016891
106PLK20.37731989
107PRKCQ0.37179354
108RPS6KA10.36780679
109PRKCD0.34563841
110CAMK2G0.34552497
111PRKCE0.34206909
112PRKACA0.34144607
113NTRK20.33418953
114CSNK1E0.32639396
115MAPK130.32584336
116SGK10.31195032
117PASK0.31049276
118VRK20.30465208
119DYRK20.30449294
120PRKCA0.30092725
121CAMKK20.29925919
122CASK0.29893371
123MST40.29587809
124PRKAA10.29357255
125IRAK10.29271640
126EPHA30.28815401
127TGFBR10.28418285
128NEK90.26730946
129PRKCZ0.26523379
130CAMK2A0.25875049
131RPS6KA20.25204337
132FGFR20.24618987
133PAK10.24125039
134MAP2K20.23981431
135ATM0.23483667
136EIF2AK10.23450133
137IRAK20.22987755
138PRKDC0.21712913
139AKT30.21706184
140STK30.21048504
141CDK180.20746601
142PRKCI0.20657513
143GRK60.20301841
144MST1R0.19885314
145MARK20.19882191
146CDK90.19708493
147CSNK2A10.18957810
148CAMK2B0.18921734
149STK160.17996452
150PDPK10.17938533
151CDK150.17774720
152IGF1R0.17293435
153CSNK2A20.17248789
154CDK140.16154671
155PRKAA20.16151519
156PAK30.15976058
157SRPK10.15815043
158PRKG10.15642858

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.23519066
2Phenylalanine metabolism_Homo sapiens_hsa003603.56883983
3Histidine metabolism_Homo sapiens_hsa003403.55798235
4Tyrosine metabolism_Homo sapiens_hsa003503.04781722
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.96861411
6Caffeine metabolism_Homo sapiens_hsa002322.90604566
7beta-Alanine metabolism_Homo sapiens_hsa004102.79818107
8Basal transcription factors_Homo sapiens_hsa030222.32896686
9Glutathione metabolism_Homo sapiens_hsa004802.32055409
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.27417146
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12004484
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.08157557
13ABC transporters_Homo sapiens_hsa020102.07395914
14Fatty acid biosynthesis_Homo sapiens_hsa000612.06925367
15Collecting duct acid secretion_Homo sapiens_hsa049662.02085935
16Mineral absorption_Homo sapiens_hsa049782.01850004
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91979129
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83623393
19Graft-versus-host disease_Homo sapiens_hsa053321.80302076
20Huntingtons disease_Homo sapiens_hsa050161.72349874
21Proteasome_Homo sapiens_hsa030501.69855714
22Phototransduction_Homo sapiens_hsa047441.64389927
23Synaptic vesicle cycle_Homo sapiens_hsa047211.64338804
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61479844
25Purine metabolism_Homo sapiens_hsa002301.61216955
26Oocyte meiosis_Homo sapiens_hsa041141.59262038
27Chemical carcinogenesis_Homo sapiens_hsa052041.59101000
28Pyruvate metabolism_Homo sapiens_hsa006201.53967877
29Fanconi anemia pathway_Homo sapiens_hsa034601.44542842
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43960861
31Nucleotide excision repair_Homo sapiens_hsa034201.40625266
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.40057331
33Propanoate metabolism_Homo sapiens_hsa006401.39992974
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38501296
35Ovarian steroidogenesis_Homo sapiens_hsa049131.35948183
36Pyrimidine metabolism_Homo sapiens_hsa002401.35416036
37Linoleic acid metabolism_Homo sapiens_hsa005911.33160557
38Protein export_Homo sapiens_hsa030601.32847745
39Fatty acid degradation_Homo sapiens_hsa000711.32665720
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31089872
41Nicotine addiction_Homo sapiens_hsa050331.27903195
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24642801
43Peroxisome_Homo sapiens_hsa041461.22761111
44Regulation of autophagy_Homo sapiens_hsa041401.20438330
45Parkinsons disease_Homo sapiens_hsa050121.17981667
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17137555
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16071303
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14528212
49RNA transport_Homo sapiens_hsa030131.14408174
50Olfactory transduction_Homo sapiens_hsa047401.14110098
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.13930768
52African trypanosomiasis_Homo sapiens_hsa051431.11613069
53Arachidonic acid metabolism_Homo sapiens_hsa005901.11291229
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.10841202
55Amphetamine addiction_Homo sapiens_hsa050311.09519665
56Tryptophan metabolism_Homo sapiens_hsa003801.03960000
57Prion diseases_Homo sapiens_hsa050201.03272926
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02625608
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98811362
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98163228
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97487293
62Glucagon signaling pathway_Homo sapiens_hsa049220.97149847
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96254631
64Rheumatoid arthritis_Homo sapiens_hsa053230.95391723
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94320691
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88496002
67Inositol phosphate metabolism_Homo sapiens_hsa005620.87809275
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86172572
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.86022122
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83270225
71Cardiac muscle contraction_Homo sapiens_hsa042600.82531963
72Glycerolipid metabolism_Homo sapiens_hsa005610.80979585
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80775217
74Sphingolipid metabolism_Homo sapiens_hsa006000.80482205
75Circadian rhythm_Homo sapiens_hsa047100.79966742
76Basal cell carcinoma_Homo sapiens_hsa052170.79356631
77Alzheimers disease_Homo sapiens_hsa050100.78486820
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72244137
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71253102
80Carbon metabolism_Homo sapiens_hsa012000.71086544
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.69187516
82Tight junction_Homo sapiens_hsa045300.68962321
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68533008
84Insulin secretion_Homo sapiens_hsa049110.66938358
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64708168
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.63860749
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63839755
88Cocaine addiction_Homo sapiens_hsa050300.62539338
89Base excision repair_Homo sapiens_hsa034100.62395194
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62358095
91Calcium signaling pathway_Homo sapiens_hsa040200.62156595
92Nitrogen metabolism_Homo sapiens_hsa009100.61881208
93Cell cycle_Homo sapiens_hsa041100.61867264
94Retinol metabolism_Homo sapiens_hsa008300.60523027
95Legionellosis_Homo sapiens_hsa051340.59951177
96Homologous recombination_Homo sapiens_hsa034400.59782413
97Gastric acid secretion_Homo sapiens_hsa049710.57114264
98Metabolic pathways_Homo sapiens_hsa011000.56889049
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.56256987
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54099998
101RNA polymerase_Homo sapiens_hsa030200.53973994
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51039985
103Bile secretion_Homo sapiens_hsa049760.50879285
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50747500
105Circadian entrainment_Homo sapiens_hsa047130.50599466
106Non-homologous end-joining_Homo sapiens_hsa034500.50569773
107Taste transduction_Homo sapiens_hsa047420.50022718
108Steroid biosynthesis_Homo sapiens_hsa001000.49645434
109Renin secretion_Homo sapiens_hsa049240.49231274
110Starch and sucrose metabolism_Homo sapiens_hsa005000.48177923
111Salivary secretion_Homo sapiens_hsa049700.47894001
112Fructose and mannose metabolism_Homo sapiens_hsa000510.47613256
113Thyroid hormone synthesis_Homo sapiens_hsa049180.43599045
114Mismatch repair_Homo sapiens_hsa034300.40778817
115Vitamin digestion and absorption_Homo sapiens_hsa049770.38994236
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38798114
117Ribosome_Homo sapiens_hsa030100.38588977
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38114880
119Ether lipid metabolism_Homo sapiens_hsa005650.38006550
120Biosynthesis of amino acids_Homo sapiens_hsa012300.37272431
121Arginine and proline metabolism_Homo sapiens_hsa003300.36734863
122Notch signaling pathway_Homo sapiens_hsa043300.36250483
123GnRH signaling pathway_Homo sapiens_hsa049120.36240111
124Butanoate metabolism_Homo sapiens_hsa006500.36175736
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35102303
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35017244
127Serotonergic synapse_Homo sapiens_hsa047260.34555875
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34534219
129Estrogen signaling pathway_Homo sapiens_hsa049150.34075842
130Hedgehog signaling pathway_Homo sapiens_hsa043400.34062631
131Oxidative phosphorylation_Homo sapiens_hsa001900.33435409
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32415464
133Selenocompound metabolism_Homo sapiens_hsa004500.30934600
134PPAR signaling pathway_Homo sapiens_hsa033200.30653058
135Antigen processing and presentation_Homo sapiens_hsa046120.29609949
136Hippo signaling pathway_Homo sapiens_hsa043900.29110091
137Axon guidance_Homo sapiens_hsa043600.28635080
138cAMP signaling pathway_Homo sapiens_hsa040240.28231076
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25448124
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23446541
141Glutamatergic synapse_Homo sapiens_hsa047240.23201243
142Complement and coagulation cascades_Homo sapiens_hsa046100.22546534
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22058441
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21602612
145Folate biosynthesis_Homo sapiens_hsa007900.21442367
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.18164538

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