DYNAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesodermal cell differentiation (GO:0048333)8.50985728
2cell adhesion mediated by integrin (GO:0033627)7.26779908
3hemidesmosome assembly (GO:0031581)6.64012658
4regulation of vascular endothelial growth factor signaling pathway (GO:1900746)5.67517013
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.37278072
6plasma membrane repair (GO:0001778)5.35305700
7endodermal cell differentiation (GO:0035987)5.34368517
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.23345626
9chondrocyte proliferation (GO:0035988)5.22574937
10negative regulation of macrophage differentiation (GO:0045650)5.12153540
11cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.07076849
12positive regulation of osteoblast proliferation (GO:0033690)4.85605968
13regulation of gonadotropin secretion (GO:0032276)4.83212372
14indolalkylamine metabolic process (GO:0006586)4.48751077
15eyelid development in camera-type eye (GO:0061029)4.47926790
16tryptophan catabolic process (GO:0006569)4.44441685
17indole-containing compound catabolic process (GO:0042436)4.44441685
18indolalkylamine catabolic process (GO:0046218)4.44441685
19histone-serine phosphorylation (GO:0035404)4.38785645
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.35174850
21neural tube formation (GO:0001841)4.34761904
22heterochromatin organization (GO:0070828)4.33123074
23signal peptide processing (GO:0006465)4.29124187
24protein K11-linked deubiquitination (GO:0035871)4.26289575
25hemoglobin metabolic process (GO:0020027)4.19190943
26positive regulation of astrocyte differentiation (GO:0048711)4.17179275
27cilium or flagellum-dependent cell motility (GO:0001539)4.13900952
28detection of light stimulus involved in visual perception (GO:0050908)4.05452338
29detection of light stimulus involved in sensory perception (GO:0050962)4.05452338
30DNA double-strand break processing (GO:0000729)4.04327001
31kynurenine metabolic process (GO:0070189)4.02186462
32skin morphogenesis (GO:0043589)3.99558695
33photoreceptor cell maintenance (GO:0045494)3.94764403
34tryptophan metabolic process (GO:0006568)3.91715641
35monoubiquitinated protein deubiquitination (GO:0035520)3.79416105
36positive regulation of Rho protein signal transduction (GO:0035025)3.75211205
37tachykinin receptor signaling pathway (GO:0007217)3.74477484
38response to follicle-stimulating hormone (GO:0032354)3.73754005
39behavioral response to ethanol (GO:0048149)3.70062491
40cell-substrate junction assembly (GO:0007044)3.68061274
41reflex (GO:0060004)3.64930182
42atrioventricular valve morphogenesis (GO:0003181)3.63078819
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62401016
44cellular response to vitamin D (GO:0071305)3.60791525
45grooming behavior (GO:0007625)3.58124589
46lung-associated mesenchyme development (GO:0060484)3.56014845
47ribosome assembly (GO:0042255)3.52556246
48response to pheromone (GO:0019236)3.50155035
49positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.50130833
50establishment of protein localization to Golgi (GO:0072600)3.49838246
51positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.48429178
52endocrine hormone secretion (GO:0060986)3.46759684
53fucose catabolic process (GO:0019317)3.43914460
54L-fucose metabolic process (GO:0042354)3.43914460
55L-fucose catabolic process (GO:0042355)3.43914460
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42204658
57regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.38454319
58regulation of hippo signaling (GO:0035330)3.36049750
59regulation of spindle organization (GO:0090224)3.35252607
60regulation of sarcomere organization (GO:0060297)3.34854245
61regulation of mitotic spindle organization (GO:0060236)3.31773484
62formation of translation preinitiation complex (GO:0001731)3.30377089
63regulation of meiosis I (GO:0060631)3.29760472
64negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.28104024
65mesenchymal-epithelial cell signaling (GO:0060638)3.26285611
66epithelial cell-cell adhesion (GO:0090136)3.25375132
67mitotic G1 DNA damage checkpoint (GO:0031571)3.24684850
68stress fiber assembly (GO:0043149)3.24571796
69tyrosine phosphorylation of STAT protein (GO:0007260)3.23520185
70substrate-dependent cell migration (GO:0006929)3.22989505
71cellular response to cholesterol (GO:0071397)3.21643044
72positive regulation of macrophage activation (GO:0043032)3.19232382
73polarized epithelial cell differentiation (GO:0030859)3.18453932
74piRNA metabolic process (GO:0034587)3.17710376
75replication fork processing (GO:0031297)3.16535797
76hippo signaling (GO:0035329)3.15807104
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15354967
78benzene-containing compound metabolic process (GO:0042537)3.14987986
79regulation of feeding behavior (GO:0060259)3.13282452
80indole-containing compound metabolic process (GO:0042430)3.12715343
81negative regulation of interferon-gamma production (GO:0032689)3.10781353
82double-strand break repair via homologous recombination (GO:0000724)3.09848089
83recombinational repair (GO:0000725)3.08461188
84DNA methylation involved in gamete generation (GO:0043046)3.07611607
85retinal cone cell development (GO:0046549)3.06733579
86purine nucleobase biosynthetic process (GO:0009113)3.05248879
87cell migration involved in sprouting angiogenesis (GO:0002042)3.05149299
88activin receptor signaling pathway (GO:0032924)3.03117298
89righting reflex (GO:0060013)3.02109139
90skeletal muscle tissue regeneration (GO:0043403)2.99204241
91positive regulation of developmental pigmentation (GO:0048087)2.98488707
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98196938
93regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.98144972
94positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.98107667
95amine catabolic process (GO:0009310)2.95319961
96cellular biogenic amine catabolic process (GO:0042402)2.95319961
97labyrinthine layer blood vessel development (GO:0060716)2.94842701
98cellular ketone body metabolic process (GO:0046950)2.94498498
99cilium morphogenesis (GO:0060271)2.94433527
100mitotic G1/S transition checkpoint (GO:0044819)2.90671686
101G1 DNA damage checkpoint (GO:0044783)2.90526705
102mammary gland epithelial cell proliferation (GO:0033598)2.90513202
103auditory receptor cell stereocilium organization (GO:0060088)2.87405936
104axoneme assembly (GO:0035082)2.87350674
105thyroid hormone metabolic process (GO:0042403)2.87331326
106protein K48-linked deubiquitination (GO:0071108)2.86595462
107mature B cell differentiation involved in immune response (GO:0002313)2.86340697
108gamma-aminobutyric acid transport (GO:0015812)2.85958997
109muscle cell fate commitment (GO:0042693)2.85084482
110negative regulation of translation, ncRNA-mediated (GO:0040033)2.84411527
111regulation of translation, ncRNA-mediated (GO:0045974)2.84411527
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84411527
113sphingoid metabolic process (GO:0046519)2.84175976
114prenylation (GO:0097354)2.82683009
115protein prenylation (GO:0018342)2.82683009
116negative regulation of fatty acid transport (GO:2000192)2.80556674
117regulation of posttranscriptional gene silencing (GO:0060147)2.79373080
118regulation of gene silencing by miRNA (GO:0060964)2.79373080
119regulation of gene silencing by RNA (GO:0060966)2.79373080
120positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.79207343
121UDP-N-acetylglucosamine metabolic process (GO:0006047)2.79084014
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78756088
123decidualization (GO:0046697)2.78132334
124proline transport (GO:0015824)2.77322735
125regulation of integrin-mediated signaling pathway (GO:2001044)2.76206633
126regulation of pigment cell differentiation (GO:0050932)2.75882848
127positive regulation of chemokine secretion (GO:0090197)2.73648844
128regulation of protein heterodimerization activity (GO:0043497)2.72100093
129detection of mechanical stimulus involved in sensory perception (GO:0050974)2.71960677
130behavioral response to nicotine (GO:0035095)2.71746061
131positive regulation of p38MAPK cascade (GO:1900745)2.71101798
132negative regulation of mast cell activation (GO:0033004)2.70506843
133NAD biosynthetic process (GO:0009435)2.70377514
134cilium organization (GO:0044782)2.70135158
135cellular response to interferon-alpha (GO:0035457)2.69667740
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.68508055
137cilium assembly (GO:0042384)2.67761500
138lymphangiogenesis (GO:0001946)2.67551381
139protein K63-linked deubiquitination (GO:0070536)2.67454816
140response to gonadotropin (GO:0034698)2.66807286
141centriole replication (GO:0007099)2.66490018
142lens fiber cell development (GO:0070307)2.66069060
143nonmotile primary cilium assembly (GO:0035058)2.65433800
144positive regulation of protein localization to plasma membrane (GO:1903078)2.64931974
145membrane raft organization (GO:0031579)2.64455158
146mitotic G2 DNA damage checkpoint (GO:0007095)2.63579922
147protein targeting to Golgi (GO:0000042)2.63153432
148inner ear receptor stereocilium organization (GO:0060122)2.63067288
149cellular response to vitamin (GO:0071295)2.62720641
150negative regulation of DNA repair (GO:0045738)2.62569366
151regulation of cell aging (GO:0090342)2.62303893
152nucleobase biosynthetic process (GO:0046112)2.61766540
153activation of Rac GTPase activity (GO:0032863)2.60342472
154ketone body metabolic process (GO:1902224)2.60205300
155membrane budding (GO:0006900)2.58230131
156regulation of collagen metabolic process (GO:0010712)2.58117471
157regulation of cellular senescence (GO:2000772)2.57075538
158epithelial cilium movement (GO:0003351)2.56976489
159regulation of chemokine secretion (GO:0090196)2.56855258
160regulation of collateral sprouting (GO:0048670)2.55966428
161adaptation of signaling pathway (GO:0023058)2.55491685
162dopamine transport (GO:0015872)2.55176580
163adherens junction assembly (GO:0034333)2.54253656
164reciprocal DNA recombination (GO:0035825)2.54123714
165reciprocal meiotic recombination (GO:0007131)2.54123714
166microtubule anchoring (GO:0034453)2.54047189
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.53264697
168cilium movement (GO:0003341)2.53192385
169aromatic amino acid family catabolic process (GO:0009074)2.52300997
170hypotonic response (GO:0006971)2.52031336
171placenta blood vessel development (GO:0060674)2.51306371
172regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50385971
173positive regulation of interleukin-8 secretion (GO:2000484)2.49826761
174serotonin metabolic process (GO:0042428)2.49089431
175cornea development in camera-type eye (GO:0061303)2.49013097
176regulation of osteoblast proliferation (GO:0033688)2.48605987
177aromatic amino acid family metabolic process (GO:0009072)2.48401432
178endothelial cell morphogenesis (GO:0001886)2.48245586
179regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.48143044
180methionine biosynthetic process (GO:0009086)2.47988595
181hepatocyte differentiation (GO:0070365)2.47234782
182regulation of glomerular filtration (GO:0003093)2.47016878
183* cellular response to sterol (GO:0036315)2.46928690
184photoreceptor cell development (GO:0042461)2.46479924
185protein localization to kinetochore (GO:0034501)2.46379081
186oxidative demethylation (GO:0070989)2.45672203
187rhodopsin mediated signaling pathway (GO:0016056)2.45537419
188embryonic epithelial tube formation (GO:0001838)2.45509159
189mitotic nuclear envelope disassembly (GO:0007077)2.45498169
190negative regulation of systemic arterial blood pressure (GO:0003085)2.45364906
191serotonin receptor signaling pathway (GO:0007210)2.45281386
192substrate adhesion-dependent cell spreading (GO:0034446)2.45194232
193negative regulation of hormone biosynthetic process (GO:0032353)2.45131713
194negative regulation of hormone metabolic process (GO:0032351)2.45131713
195wound healing (GO:0042060)2.44701746
196retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43085557
197regulation of early endosome to late endosome transport (GO:2000641)2.42750743
198regulation of cilium movement (GO:0003352)2.42580759
199intraciliary transport (GO:0042073)2.42132213
200snRNA transcription (GO:0009301)2.42111518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.63077080
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.64400301
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.41603977
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.78315442
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.64500680
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.54835752
7GBX2_23144817_ChIP-Seq_PC3_Human3.42881091
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12218984
9IGF1R_20145208_ChIP-Seq_DFB_Human3.10567344
10VDR_22108803_ChIP-Seq_LS180_Human3.09806986
11AR_21909140_ChIP-Seq_LNCAP_Human3.04696059
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.01735623
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88259385
14ZNF263_19887448_ChIP-Seq_K562_Human2.86706006
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85794132
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.78695300
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77250049
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71062123
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.59972097
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.59972097
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.53196637
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51152093
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.50126904
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47772454
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39723276
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39108488
27CLOCK_20551151_ChIP-Seq_293T_Human2.37229672
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.33943860
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.32898422
30TAF15_26573619_Chip-Seq_HEK293_Human2.30824429
31P300_19829295_ChIP-Seq_ESCs_Human2.27339514
32FUS_26573619_Chip-Seq_HEK293_Human2.21554956
33ELK1_22589737_ChIP-Seq_MCF10A_Human2.17344862
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11014703
35HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07220897
36EWS_26573619_Chip-Seq_HEK293_Human2.07090262
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04153475
38ATF3_27146783_Chip-Seq_COLON_Human2.00634522
39BRD4_25478319_ChIP-Seq_HGPS_Human2.00560168
40ER_23166858_ChIP-Seq_MCF-7_Human1.97172796
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94819476
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94010115
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.93585796
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92364323
45STAT3_23295773_ChIP-Seq_U87_Human1.87899130
46ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.82995392
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82903065
48SMAD4_21799915_ChIP-Seq_A2780_Human1.82196549
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.82044814
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79163739
51CJUN_26792858_Chip-Seq_BT549_Human1.78679335
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78463745
53EZH2_22144423_ChIP-Seq_EOC_Human1.77153450
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76537117
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73125978
56BCAT_22108803_ChIP-Seq_LS180_Human1.72878503
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.72795771
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72228926
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72022728
60EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.69678542
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69241029
62TCF4_23295773_ChIP-Seq_U87_Human1.68421730
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67948966
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67409243
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65736522
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.64360627
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63742139
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62647787
69CBP_20019798_ChIP-Seq_JUKART_Human1.62647787
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.61042873
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.60613108
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59030812
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.57473815
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57014325
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55880464
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55414411
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54759317
78AR_25329375_ChIP-Seq_VCAP_Human1.52943170
79AR_21572438_ChIP-Seq_LNCaP_Human1.52156119
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.51202103
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49679655
82RACK7_27058665_Chip-Seq_MCF-7_Human1.46557508
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46057400
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45421056
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43499536
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43199165
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42487713
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41778801
89TCF4_22108803_ChIP-Seq_LS180_Human1.41757589
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.41336651
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41101971
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41044983
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41044983
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40397338
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.39698055
96E2F7_22180533_ChIP-Seq_HELA_Human1.39599574
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39389792
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38301853
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36766343
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36696025
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36364702
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35464999
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35291088
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35107287
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34806642
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34568165
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34151950
108SOX2_20726797_ChIP-Seq_SW620_Human1.34002169
109RUNX2_22187159_ChIP-Seq_PCA_Human1.34002041
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.33449903
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33070341
112SOX2_19829295_ChIP-Seq_ESCs_Human1.33061329
113NANOG_19829295_ChIP-Seq_ESCs_Human1.33061329
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33054462
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32546379
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.30995804
117CHD1_26751641_Chip-Seq_LNCaP_Human1.30455884
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29382310
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28794897
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.28522299
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28501659
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28237870
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.27987429
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27289430
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26522964
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26175704
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25133756
128FOXO3_23340844_ChIP-Seq_DLD1_Human1.25046258
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.24994861
130CDX2_22108803_ChIP-Seq_LS180_Human1.24766332
131TP53_22573176_ChIP-Seq_HFKS_Human1.24500874
132ELK1_19687146_ChIP-ChIP_HELA_Human1.22177525
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21158904
134IRF1_19129219_ChIP-ChIP_H3396_Human1.20341608
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19529909
136CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19195503
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18886216
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18743870
139MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18266602
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16995098
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16558488
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16223941
143NOTCH1_21737748_ChIP-Seq_TLL_Human1.14744916
144P53_22387025_ChIP-Seq_ESCs_Mouse1.13626709
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13452473
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.13318414
147SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12716318
148DCP1A_22483619_ChIP-Seq_HELA_Human1.12190390
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10864187
150MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10710613
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09983950
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09911436
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09435417
154FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09254888
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09098483
156TP53_22127205_ChIP-Seq_IMR90_Human1.08742839
157XRN2_22483619_ChIP-Seq_HELA_Human1.08069439
158MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07922532
159SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07907125
160ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07582820
161HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06707530
162STAT3_18555785_Chip-Seq_ESCs_Mouse1.06581539
163HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06510287
164KLF5_25053715_ChIP-Seq_YYC3_Human1.06354374
165SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05412774
166P300_18555785_Chip-Seq_ESCs_Mouse1.04834480
167P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04529241
168CMYC_18555785_Chip-Seq_ESCs_Mouse1.04462757
169HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04373795
170SOX2_21211035_ChIP-Seq_LN229_Gbm1.04028074
171TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03810021
172KDM2B_26808549_Chip-Seq_REH_Human1.03142132
173RUNX1_27514584_Chip-Seq_MCF-7_Human1.02888167
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02042644
175ETS1_20019798_ChIP-Seq_JURKAT_Human1.01866588
176MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00012990
177GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99110554
178CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98363448
179GATA3_24758297_ChIP-Seq_MCF-7_Human0.98284752
180ZNF274_21170338_ChIP-Seq_K562_Hela0.98147999
181ARNT_22903824_ChIP-Seq_MCF-7_Human0.97766131
182ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97416768
183MYC_22102868_ChIP-Seq_BL_Human0.97029190
184EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96987258
185FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96927886
186FOXA1_25329375_ChIP-Seq_VCAP_Human0.96927886
187KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96729166
188MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95589471
189TP53_16413492_ChIP-PET_HCT116_Human0.94632127
190CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92158995
191HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91032724
192FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90210366
193E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88647351
194NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88215962
195NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88178663
196NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88178663
197GATA6_25053715_ChIP-Seq_YYC3_Human0.87870850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.26234072
2MP0010352_gastrointestinal_tract_polyps3.76538598
3MP0000733_abnormal_muscle_development3.47276464
4MP0000569_abnormal_digit_pigmentation3.44300562
5MP0005623_abnormal_meninges_morphology3.40757608
6MP0001299_abnormal_eye_distance/3.40334500
7MP0000750_abnormal_muscle_regeneration3.37885398
8MP0002877_abnormal_melanocyte_morpholog3.03658700
9MP0008057_abnormal_DNA_replication2.96973785
10MP0008877_abnormal_DNA_methylation2.76927963
11MP0005551_abnormal_eye_electrophysiolog2.76501893
12MP0009053_abnormal_anal_canal2.68875055
13MP0005187_abnormal_penis_morphology2.63938718
14MP0003136_yellow_coat_color2.50915415
15MP0002736_abnormal_nociception_after2.46652754
16MP0001968_abnormal_touch/_nociception2.44355495
17MP0010030_abnormal_orbit_morphology2.41414798
18MP0002102_abnormal_ear_morphology2.32529120
19MP0009046_muscle_twitch2.31883197
20MP0005646_abnormal_pituitary_gland2.27126239
21MP0001501_abnormal_sleep_pattern2.17617717
22MP0003566_abnormal_cell_adhesion2.17023690
23MP0000537_abnormal_urethra_morphology2.16941217
24MP0005023_abnormal_wound_healing2.13626929
25MP0002234_abnormal_pharynx_morphology2.11677968
26MP0003646_muscle_fatigue2.06962735
27MP0004043_abnormal_pH_regulation2.04719840
28MP0003091_abnormal_cell_migration2.01238463
29MP0005275_abnormal_skin_tensile1.99657770
30MP0009384_cardiac_valve_regurgitation1.96055996
31MP0001849_ear_inflammation1.87428888
32MP0005253_abnormal_eye_physiology1.87282776
33MP0000372_irregular_coat_pigmentation1.85767559
34MP0002837_dystrophic_cardiac_calcinosis1.85016705
35MP0001984_abnormal_olfaction1.84571078
36MP0000427_abnormal_hair_cycle1.80973293
37MP0005174_abnormal_tail_pigmentation1.80498971
38MP0000749_muscle_degeneration1.79372280
39MP0008438_abnormal_cutaneous_collagen1.73925776
40MP0002138_abnormal_hepatobiliary_system1.68506840
41MP0003890_abnormal_embryonic-extraembry1.67474620
42MP0009745_abnormal_behavioral_response1.67444201
43MP0004147_increased_porphyrin_level1.64464297
44MP0004272_abnormal_basement_membrane1.63680418
45MP0001486_abnormal_startle_reflex1.61290573
46MP0000762_abnormal_tongue_morphology1.61148694
47MP0008872_abnormal_physiological_respon1.60065248
48MP0006054_spinal_hemorrhage1.59510311
49MP0002060_abnormal_skin_morphology1.59268211
50MP0000747_muscle_weakness1.59063148
51MP0002876_abnormal_thyroid_physiology1.56378339
52MP0004957_abnormal_blastocyst_morpholog1.55759592
53MP0006292_abnormal_olfactory_placode1.53974037
54MP0002896_abnormal_bone_mineralization1.50973813
55MP0002938_white_spotting1.49386304
56MP0006072_abnormal_retinal_apoptosis1.49302889
57MP0001529_abnormal_vocalization1.45339528
58MP0000631_abnormal_neuroendocrine_gland1.42752527
59MP0000627_abnormal_mammary_gland1.42497488
60MP0000858_altered_metastatic_potential1.41974970
61MP0009250_abnormal_appendicular_skeleto1.41062177
62MP0006276_abnormal_autonomic_nervous1.39757350
63MP0003453_abnormal_keratinocyte_physiol1.38603732
64MP0001986_abnormal_taste_sensitivity1.38558498
65MP0000534_abnormal_ureter_morphology1.38485282
66MP0003787_abnormal_imprinting1.37113791
67MP0010368_abnormal_lymphatic_system1.36720781
68MP0003045_fibrosis1.36107918
69MP0001485_abnormal_pinna_reflex1.35702134
70MP0000428_abnormal_craniofacial_morphol1.35609759
71MP0003937_abnormal_limbs/digits/tail_de1.34755222
72MP0003252_abnormal_bile_duct1.34620290
73MP0008007_abnormal_cellular_replicative1.32225730
74MP0002272_abnormal_nervous_system1.27973978
75MP0002735_abnormal_chemical_nociception1.27205502
76MP0002098_abnormal_vibrissa_morphology1.26489573
77MP0008058_abnormal_DNA_repair1.24845816
78MP0005076_abnormal_cell_differentiation1.24360212
79MP0002928_abnormal_bile_duct1.23853284
80MP0005386_behavior/neurological_phenoty1.23210781
81MP0004924_abnormal_behavior1.23210781
82MP0003950_abnormal_plasma_membrane1.23159756
83MP0010094_abnormal_chromosome_stability1.21774369
84MP0001764_abnormal_homeostasis1.21653484
85MP0001730_embryonic_growth_arrest1.21452758
86MP0005171_absent_coat_pigmentation1.21173870
87MP0004142_abnormal_muscle_tone1.21068178
88MP0010386_abnormal_urinary_bladder1.20561493
89MP0003718_maternal_effect1.19490379
90MP0004808_abnormal_hematopoietic_stem1.19235607
91MP0001216_abnormal_epidermal_layer1.16938475
92MP0000751_myopathy1.16415927
93MP0003880_abnormal_central_pattern1.16136810
94MP0003755_abnormal_palate_morphology1.15546107
95MP0002095_abnormal_skin_pigmentation1.15472857
96MP0000015_abnormal_ear_pigmentation1.15036976
97MP0010234_abnormal_vibrissa_follicle1.14848165
98MP0005645_abnormal_hypothalamus_physiol1.14847951
99MP0008995_early_reproductive_senescence1.13043697
100MP0005508_abnormal_skeleton_morphology1.12984196
101MP0004084_abnormal_cardiac_muscle1.12943660
102MP0005085_abnormal_gallbladder_physiolo1.12474821
103MP0005501_abnormal_skin_physiology1.11371477
104MP0008932_abnormal_embryonic_tissue1.11068963
105MP0005410_abnormal_fertilization1.09721893
106MP0000432_abnormal_head_morphology1.09450942
107MP0001243_abnormal_dermal_layer1.09046851
108MP0000163_abnormal_cartilage_morphology1.08717396
109MP0005647_abnormal_sex_gland1.08428099
110MP0009697_abnormal_copulation1.08296077
111MP0005670_abnormal_white_adipose1.07514798
112MP0004197_abnormal_fetal_growth/weight/1.07103478
113MP0005395_other_phenotype1.06850263
114MP0002572_abnormal_emotion/affect_behav1.06635233
115MP0005310_abnormal_salivary_gland1.06100059
116MP0003698_abnormal_male_reproductive1.05600571
117MP0010771_integument_phenotype1.05429594
118MP0003111_abnormal_nucleus_morphology1.04790456
119MP0004215_abnormal_myocardial_fiber1.04180937
120MP0002269_muscular_atrophy1.03990347
121MP0000647_abnormal_sebaceous_gland1.02872302
122MP0003279_aneurysm1.00857587
123MP0004087_abnormal_muscle_fiber1.00538487
124MP0000759_abnormal_skeletal_muscle0.99908781
125MP0002067_abnormal_sensory_capabilities0.99380211
126MP0002653_abnormal_ependyma_morphology0.98880424
127MP0004133_heterotaxia0.98644147
128MP0002086_abnormal_extraembryonic_tissu0.98516121
129MP0003984_embryonic_growth_retardation0.98304885
130MP0000377_abnormal_hair_follicle0.98119495
131MP0008875_abnormal_xenobiotic_pharmacok0.98064060
132MP0002557_abnormal_social/conspecific_i0.97773366
133MP0003077_abnormal_cell_cycle0.97693810
134MP0003942_abnormal_urinary_system0.97591350
135MP0002638_abnormal_pupillary_reflex0.96741050
136MP0002229_neurodegeneration0.96620957
137MP0002168_other_aberrant_phenotype0.96469505
138MP0002796_impaired_skin_barrier0.96147135
139MP0010678_abnormal_skin_adnexa0.94917126
140MP0000350_abnormal_cell_proliferation0.94273139
141MP0002064_seizures0.93948089
142MP0003693_abnormal_embryo_hatching0.93848489
143MP0002932_abnormal_joint_morphology0.93761354
144MP0001697_abnormal_embryo_size0.93507585
145MP0005621_abnormal_cell_physiology0.93428883
146MP0005195_abnormal_posterior_eye0.93403653
147MP0000538_abnormal_urinary_bladder0.92737464
148MP0001970_abnormal_pain_threshold0.92413884
149MP0001672_abnormal_embryogenesis/_devel0.91845054
150MP0005380_embryogenesis_phenotype0.91845054
151MP0003385_abnormal_body_wall0.91731082
152MP0002084_abnormal_developmental_patter0.91689523
153MP0002177_abnormal_outer_ear0.91536527
154MP0000383_abnormal_hair_follicle0.91238190
155MP0004947_skin_inflammation0.91205924
156MP0010307_abnormal_tumor_latency0.90751811
157MP0003936_abnormal_reproductive_system0.90564131
158MP0002088_abnormal_embryonic_growth/wei0.90503068
159MP0005193_abnormal_anterior_eye0.89484094
160MP0003121_genomic_imprinting0.89400081
161MP0001346_abnormal_lacrimal_gland0.88071496
162MP0001929_abnormal_gametogenesis0.86220837
163MP0000767_abnormal_smooth_muscle0.86157379
164MP0002090_abnormal_vision0.86048219
165MP0001324_abnormal_eye_pigmentation0.85775404
166MP0008770_decreased_survivor_rate0.85577094
167MP0001542_abnormal_bone_strength0.85358771
168MP0003943_abnormal_hepatobiliary_system0.84667456
169MP0009672_abnormal_birth_weight0.83704918
170MP0003119_abnormal_digestive_system0.83213521
171MP0003195_calcinosis0.83016224
172MP0003115_abnormal_respiratory_system0.82757857
173MP0005377_hearing/vestibular/ear_phenot0.82687967
174MP0003878_abnormal_ear_physiology0.82687967
175MP0002925_abnormal_cardiovascular_devel0.82428416
176MP0002085_abnormal_embryonic_tissue0.82327931
177MP0008260_abnormal_autophagy0.82080047
178MP0004883_abnormal_blood_vessel0.81882427
179MP0002080_prenatal_lethality0.81817737
180MP0003183_abnormal_peptide_metabolism0.81558669
181MP0001340_abnormal_eyelid_morphology0.81317100
182MP0000653_abnormal_sex_gland0.81120586
183MP0005330_cardiomyopathy0.80982521
184MP0009780_abnormal_chondrocyte_physiolo0.78515967
185MP0002210_abnormal_sex_determination0.78225424
186MP0000516_abnormal_urinary_system0.78084885
187MP0005367_renal/urinary_system_phenotyp0.78084885
188MP0003633_abnormal_nervous_system0.77991494
189MP0002733_abnormal_thermal_nociception0.77466536
190MP0003635_abnormal_synaptic_transmissio0.77385567
191MP0003137_abnormal_impulse_conducting0.77321754
192MP0002751_abnormal_autonomic_nervous0.77245770

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)4.71661776
2Premature rupture of membranes (HP:0001788)4.64534750
3Osteolytic defects of the phalanges of the hand (HP:0009771)4.63890786
4Osteolytic defects of the hand bones (HP:0009699)4.63890786
5Atrophic scars (HP:0001075)4.62902482
6Pancreatic cysts (HP:0001737)4.44910119
7Short nail (HP:0001799)4.39738373
8Milia (HP:0001056)3.93327606
9True hermaphroditism (HP:0010459)3.92627364
10Pancreatic fibrosis (HP:0100732)3.91470510
11Gaze-evoked nystagmus (HP:0000640)3.83107638
12Difficulty climbing stairs (HP:0003551)3.79390242
13Pterygium (HP:0001059)3.73292482
14Genetic anticipation (HP:0003743)3.65957838
15Molar tooth sign on MRI (HP:0002419)3.49104974
16Abnormality of midbrain morphology (HP:0002418)3.49104974
17Attenuation of retinal blood vessels (HP:0007843)3.47850149
18Protrusio acetabuli (HP:0003179)3.47718101
19Hyperventilation (HP:0002883)3.46460247
20Spinal cord lesions (HP:0100561)3.30918046
21Syringomyelia (HP:0003396)3.30918046
22Chronic hepatic failure (HP:0100626)3.29454367
23Increased connective tissue (HP:0009025)3.28801481
24Rectal prolapse (HP:0002035)3.21313015
25Abnormality of the umbilical cord (HP:0010881)3.20144264
26Congenital stationary night blindness (HP:0007642)3.20060529
27Abnormality of the renal cortex (HP:0011035)3.18968880
28Nephronophthisis (HP:0000090)3.18867802
29Fragile nails (HP:0001808)3.06648785
30Abnormality of the renal medulla (HP:0100957)2.99729490
31Progressive cerebellar ataxia (HP:0002073)2.93890186
32Abolished electroretinogram (ERG) (HP:0000550)2.90616749
33Cystic liver disease (HP:0006706)2.87808428
34Distal lower limb amyotrophy (HP:0008944)2.87062967
35Abnormality of the distal phalanges of the toes (HP:0010182)2.86052248
36Central scotoma (HP:0000603)2.85917382
37Ankle contracture (HP:0006466)2.81991051
38Wormian bones (HP:0002645)2.79844377
39Pelvic girdle muscle weakness (HP:0003749)2.78430782
40Medial flaring of the eyebrow (HP:0010747)2.76901643
41Intestinal atresia (HP:0011100)2.76260376
42Shallow orbits (HP:0000586)2.76193039
43Muscle fiber splitting (HP:0003555)2.75799731
44Congenital sensorineural hearing impairment (HP:0008527)2.74479071
45Coronal craniosynostosis (HP:0004440)2.70522016
46Increased density of long bones (HP:0006392)2.67221006
47Progressive inability to walk (HP:0002505)2.63679446
48Volvulus (HP:0002580)2.60818111
49Abnormalities of placenta or umbilical cord (HP:0001194)2.60611999
50Abnormality of the 2nd finger (HP:0004100)2.59095660
51Fatigable weakness (HP:0003473)2.58413463
52Abnormality of the neuromuscular junction (HP:0003398)2.58413463
53Wrist flexion contracture (HP:0001239)2.57516693
54Bony spicule pigmentary retinopathy (HP:0007737)2.55985776
55Absent speech (HP:0001344)2.55875018
56Chromsome breakage (HP:0040012)2.55466363
57Selective tooth agenesis (HP:0001592)2.55337749
58Abnormality of the musculature of the pelvis (HP:0001469)2.54546474
59Abnormality of the hip-girdle musculature (HP:0001445)2.54546474
60Distal upper limb amyotrophy (HP:0007149)2.53476857
61Upper limb amyotrophy (HP:0009129)2.53476857
62Shoulder girdle muscle weakness (HP:0003547)2.51644777
63Nail dystrophy (HP:0008404)2.51582347
64Abnormality of macular pigmentation (HP:0008002)2.50963460
65Febrile seizures (HP:0002373)2.48500186
66Abnormal rod and cone electroretinograms (HP:0008323)2.46394924
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45468449
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.44942268
69Fragile skin (HP:0001030)2.43797459
70Natal tooth (HP:0000695)2.43779696
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.42436382
72Spinal rigidity (HP:0003306)2.42188925
73Renal cortical cysts (HP:0000803)2.40993527
74Short hallux (HP:0010109)2.40827338
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.38452081
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.36887916
77Inability to walk (HP:0002540)2.33626513
78Cervical subluxation (HP:0003308)2.32715805
79Scotoma (HP:0000575)2.32060005
80Stillbirth (HP:0003826)2.31720820
81Muscle fiber atrophy (HP:0100295)2.31233789
82Pendular nystagmus (HP:0012043)2.30813066
83Dialeptic seizures (HP:0011146)2.29876852
84Severe visual impairment (HP:0001141)2.29797164
85Hypothermia (HP:0002045)2.29491191
86Increased corneal curvature (HP:0100692)2.26884791
87Keratoconus (HP:0000563)2.26884791
88Protruding tongue (HP:0010808)2.26077428
89Type 2 muscle fiber atrophy (HP:0003554)2.26039705
90Bile duct proliferation (HP:0001408)2.24706193
91Abnormal biliary tract physiology (HP:0012439)2.24706193
92Thyroid-stimulating hormone excess (HP:0002925)2.24282975
93Abnormality of the calcaneus (HP:0008364)2.22955913
94Subacute progressive viral hepatitis (HP:0006572)2.22568859
95Abnormality of chromosome stability (HP:0003220)2.21644974
96Constricted visual fields (HP:0001133)2.20542722
97Congenital hepatic fibrosis (HP:0002612)2.19972229
98Lower limb amyotrophy (HP:0007210)2.19768270
99Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19668211
100Congenital primary aphakia (HP:0007707)2.19145925
101Entropion (HP:0000621)2.19040829
102Oligodontia (HP:0000677)2.18122541
103Gait imbalance (HP:0002141)2.17775162
104Focal seizures (HP:0007359)2.16305027
105Fair hair (HP:0002286)2.15494051
106Popliteal pterygium (HP:0009756)2.15265543
107Achilles tendon contracture (HP:0001771)2.14108589
108Anencephaly (HP:0002323)2.13641844
109Abnormality of placental membranes (HP:0011409)2.13499767
110Amniotic constriction ring (HP:0009775)2.13499767
111Sclerocornea (HP:0000647)2.13438775
112Scapular winging (HP:0003691)2.12949852
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.12776588
114Abnormal drinking behavior (HP:0030082)2.11945872
115Polydipsia (HP:0001959)2.11945872
116Clubbing of toes (HP:0100760)2.11259753
117Decreased central vision (HP:0007663)2.11201034
118Alopecia of scalp (HP:0002293)2.11160945
119Fused cervical vertebrae (HP:0002949)2.11039622
120Dilatation of the ascending aorta (HP:0005111)2.10581007
121Focal motor seizures (HP:0011153)2.09734550
122Nephrogenic diabetes insipidus (HP:0009806)2.07566091
123Widely spaced teeth (HP:0000687)2.07160282
124Abnormality of the ileum (HP:0001549)2.06748685
125Genital tract atresia (HP:0001827)2.06172644
126Small hand (HP:0200055)2.05455162
127Tubular atrophy (HP:0000092)2.05394027
128Increased neuronal autofluorescent lipopigment (HP:0002074)2.05315428
129Cerebellar dysplasia (HP:0007033)2.04942088
130Malignant hyperthermia (HP:0002047)2.04246913
131Furrowed tongue (HP:0000221)2.03423445
132Type II lissencephaly (HP:0007260)2.02300807
133Aplasia of the musculature (HP:0100854)2.01953269
134Radial bowing (HP:0002986)2.01844049
135Gowers sign (HP:0003391)1.99394471
136Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99368876
137Postaxial foot polydactyly (HP:0001830)1.97299004
138Submucous cleft hard palate (HP:0000176)1.96892531
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95895697
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95174050
141Limb-girdle muscle atrophy (HP:0003797)1.93524277
142Hypoplasia of the fovea (HP:0007750)1.93495052
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.93495052
144Vaginal atresia (HP:0000148)1.92899188
145Abnormality of the fovea (HP:0000493)1.92884527
146Absence seizures (HP:0002121)1.92429079
147Meckel diverticulum (HP:0002245)1.92244365
148Abnormality of the Achilles tendon (HP:0005109)1.91982587
149Trismus (HP:0000211)1.91239744
150Vertebral compression fractures (HP:0002953)1.91171658
151Autoamputation (HP:0001218)1.90250091
152Sloping forehead (HP:0000340)1.90142992
153Reduced subcutaneous adipose tissue (HP:0003758)1.89743304
154Clumsiness (HP:0002312)1.89708268
155Spinal cord compression (HP:0002176)1.89170655
156Abnormality of alanine metabolism (HP:0010916)1.88062400
157Hyperalaninemia (HP:0003348)1.88062400
158Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88062400
159Male pseudohermaphroditism (HP:0000037)1.87374977
160Lymphangioma (HP:0100764)1.86708418
161Abnormality of the middle phalanges of the toes (HP:0010183)1.86517839
162Astigmatism (HP:0000483)1.85939851
163Retinitis pigmentosa (HP:0000510)1.84759687
164Weak cry (HP:0001612)1.82812426
165Broad hallux (HP:0010055)1.82763934
166Ketoacidosis (HP:0001993)1.82693516
167Thyroiditis (HP:0100646)1.82391092
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82296531
169Deviation of the hallux (HP:0010051)1.81019884
170Absent/shortened dynein arms (HP:0200106)1.80515978
171Dynein arm defect of respiratory motile cilia (HP:0012255)1.80515978
172Broad face (HP:0000283)1.80095089
173Abnormality of the anterior horn cell (HP:0006802)1.79308519
174Degeneration of anterior horn cells (HP:0002398)1.79308519
175Hallux valgus (HP:0001822)1.78829143
176Abnormality of the labia minora (HP:0012880)1.78582567
177Albinism (HP:0001022)1.78062824
178Rough bone trabeculation (HP:0100670)1.77816869
179Plantar hyperkeratosis (HP:0007556)1.77449132
180Ulnar bowing (HP:0003031)1.76981397
181Macular degeneration (HP:0000608)1.76936755
182Enlarged penis (HP:0000040)1.76562771
183Broad-based gait (HP:0002136)1.75868863
184Ureteral duplication (HP:0000073)1.75715484
185Large for gestational age (HP:0001520)1.74838057
186Distal lower limb muscle weakness (HP:0009053)1.74506263
187Birth length less than 3rd percentile (HP:0003561)1.73619806
188Elbow flexion contracture (HP:0002987)1.73279857
189Ketosis (HP:0001946)1.73120067
190Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72932359
191Abnormal ciliary motility (HP:0012262)1.72682411
192Narrow mouth (HP:0000160)1.70942456
193Right ventricular cardiomyopathy (HP:0011663)1.70027155
194Glucose intolerance (HP:0000833)1.69863029
195Deviation of the thumb (HP:0009603)1.69816417
196Hand muscle atrophy (HP:0009130)1.69591923
197Conical tooth (HP:0000698)1.69585944
198Back pain (HP:0003418)1.69515062
199Thin ribs (HP:0000883)1.68082750
200Bowed forearm bones (HP:0003956)1.67025848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.83192568
2TTN4.16335740
3NME23.33781274
4MOS3.21117232
5MST1R3.10226560
6LATS12.90989861
7BMPR1B2.76579367
8WNK32.55858279
9LRRK22.53105488
10BUB12.49242070
11ADRBK22.49174258
12TRIB32.39539648
13BMX2.16276102
14MAP4K22.16204694
15STK102.13162454
16RPS6KA42.11452543
17CASK2.04893118
18DDR21.94060153
19INSRR1.93950490
20PAK21.91253535
21EPHB21.86622675
22STK38L1.83258209
23ZAK1.79124112
24MAPK131.72669691
25LATS21.72326281
26GRK11.71906142
27MET1.70645174
28STK31.70380290
29PINK11.68305625
30EEF2K1.65801319
31PTK21.56703454
32PKN21.54806585
33PAK41.54243347
34NEK21.54163360
35MAP3K41.49203638
36TRIM281.46538971
37PDGFRA1.45712639
38OXSR11.42919766
39PIK3CG1.37204250
40TNIK1.35577758
41NTRK31.33286138
42STK391.30907153
43TAOK31.30514249
44EIF2AK11.28831632
45NEK11.24746618
46CDK61.22798094
47TESK21.21661069
48BRSK21.16595731
49MAP3K81.14745621
50ADRBK11.09849516
51AKT31.05231959
52LIMK11.04950280
53TSSK61.02923865
54BCR1.02817797
55ILK1.02267524
56PIM21.01209384
57PRKCE1.00313084
58PAK31.00137496
59MAP3K20.99371951
60ROCK20.99015571
61MKNK10.98806250
62FER0.97215520
63ALK0.96576526
64PTK60.95387386
65MAP2K10.95247031
66TESK10.92128554
67PLK30.91106047
68TRPM70.89624242
69PDK40.89375935
70PDK30.89375935
71WEE10.87578294
72TEC0.86100720
73MTOR0.85630804
74PLK40.85360563
75DYRK1B0.85134065
76BCKDK0.84044000
77WNK40.83426014
78FGFR10.82710093
79TNK20.81558120
80DAPK20.80878153
81PAK10.80599317
82PDK20.79866073
83NUAK10.79855445
84MUSK0.79711953
85BRSK10.77586524
86PLK10.77517964
87CAMKK20.76862189
88IRAK10.76173360
89EPHA30.76002937
90PAK60.75996069
91AURKB0.75149741
92MELK0.75002419
93ERBB30.74424066
94TXK0.73745797
95PIK3CA0.71801117
96CSK0.71566649
97FGFR20.71321524
98FRK0.70803207
99SCYL20.69562970
100CDK140.68850128
101PRKCG0.68157556
102CDK150.67820335
103MAP2K70.67338039
104CSNK1A1L0.66120752
105RIPK10.66120321
106TTK0.64692004
107CDK180.64679555
108EPHA40.61168323
109NLK0.60979902
110MAP3K30.60361164
111EIF2AK30.60342016
112CDK11A0.58437074
113TGFBR10.58415612
114ROCK10.58120292
115SIK10.56552328
116PTK2B0.56416389
117MARK10.55827366
118STK380.53864990
119RPS6KB20.53576661
120ABL20.52986684
121BRD40.51890323
122SGK20.51481601
123ACVR1B0.51455418
124PKN10.51357338
125PDGFRB0.51214462
126CAMK2A0.50769246
127PRKAA20.49485473
128ERN10.45845409
129PRKG20.45229972
130VRK10.44577795
131CCNB10.44102718
132CAMKK10.43458440
133MARK30.43287322
134OBSCN0.41820098
135DMPK0.40810544
136EPHB10.40433206
137INSR0.40422212
138CSNK1G10.40321317
139ATM0.40277041
140EGFR0.40236124
141NEK90.40068174
142MKNK20.39356663
143PRKCQ0.38490031
144PNCK0.38361526
145CSNK1D0.38021557
146TAOK20.38018000
147PLK20.37744843
148CHEK20.37423862
149CDK190.37185921
150MAP3K70.36119756
151CSNK1A10.34967811
152ERBB20.34323590
153ATR0.34289661
154PRKACA0.33178909
155PRKACB0.32957660
156PRKG10.32721911
157TLK10.32345102
158PBK0.32210004
159CDK30.32109149
160CDK70.31900442
161CSNK1E0.31245692
162PRKAA10.31100265
163MST40.30995237
164CSNK1G30.30938822
165IKBKB0.30360468
166CSNK1G20.30264187
167ABL10.30097509
168AURKA0.29441828
169NME10.26422192
170DYRK1A0.26201748
171DYRK20.26013517
172LMTK20.25010866
173PRKCB0.23982878
174PRKCA0.23858882
175MAP2K30.22941996
176MAPKAPK20.22863798

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.11278269
2Butanoate metabolism_Homo sapiens_hsa006503.24551705
3ECM-receptor interaction_Homo sapiens_hsa045123.06598707
4Phototransduction_Homo sapiens_hsa047442.94210115
5Small cell lung cancer_Homo sapiens_hsa052222.89108144
6Homologous recombination_Homo sapiens_hsa034402.65582654
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.63827972
8Proteoglycans in cancer_Homo sapiens_hsa052052.58474554
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.49941882
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48798136
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42739072
12Fanconi anemia pathway_Homo sapiens_hsa034602.35480065
13Propanoate metabolism_Homo sapiens_hsa006402.32667331
14Focal adhesion_Homo sapiens_hsa045102.25640918
15TGF-beta signaling pathway_Homo sapiens_hsa043502.24512748
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.22735618
17RNA transport_Homo sapiens_hsa030132.19497126
18Nicotine addiction_Homo sapiens_hsa050332.17095568
19Tryptophan metabolism_Homo sapiens_hsa003802.17066144
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.10537490
21ABC transporters_Homo sapiens_hsa020102.05192118
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04288157
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04274773
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01488962
25p53 signaling pathway_Homo sapiens_hsa041152.00700675
26Bladder cancer_Homo sapiens_hsa052191.99699924
27Linoleic acid metabolism_Homo sapiens_hsa005911.97752771
28Proteasome_Homo sapiens_hsa030501.94242259
29Adherens junction_Homo sapiens_hsa045201.93057401
30Taste transduction_Homo sapiens_hsa047421.92771256
31Cell cycle_Homo sapiens_hsa041101.89364608
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88585060
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83976321
34MicroRNAs in cancer_Homo sapiens_hsa052061.83626005
35Non-homologous end-joining_Homo sapiens_hsa034501.75772646
36Selenocompound metabolism_Homo sapiens_hsa004501.75434040
37Shigellosis_Homo sapiens_hsa051311.74737300
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74567131
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.73760689
40Hippo signaling pathway_Homo sapiens_hsa043901.72985374
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.71363771
42Olfactory transduction_Homo sapiens_hsa047401.69497594
43Ether lipid metabolism_Homo sapiens_hsa005651.64380872
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.64128279
45Dilated cardiomyopathy_Homo sapiens_hsa054141.63881809
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62992761
47Chronic myeloid leukemia_Homo sapiens_hsa052201.62475602
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56742455
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45563408
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44073483
51Basal transcription factors_Homo sapiens_hsa030221.43989425
52Morphine addiction_Homo sapiens_hsa050321.43159532
53Caffeine metabolism_Homo sapiens_hsa002321.41613408
54Amoebiasis_Homo sapiens_hsa051461.40348162
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37460473
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.37281766
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37277720
58RNA polymerase_Homo sapiens_hsa030201.36459257
59Retinol metabolism_Homo sapiens_hsa008301.33844545
60beta-Alanine metabolism_Homo sapiens_hsa004101.32183319
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31322237
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.28396079
63Chemical carcinogenesis_Homo sapiens_hsa052041.27033981
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26158268
65Thyroid cancer_Homo sapiens_hsa052161.25400746
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25124359
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22781031
68Tight junction_Homo sapiens_hsa045301.22377156
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20701292
70Glycerolipid metabolism_Homo sapiens_hsa005611.17390816
71Glioma_Homo sapiens_hsa052141.14276604
72Ribosome_Homo sapiens_hsa030101.14022434
73Hedgehog signaling pathway_Homo sapiens_hsa043401.13071380
74Sphingolipid metabolism_Homo sapiens_hsa006001.12671784
75Biosynthesis of amino acids_Homo sapiens_hsa012301.10798876
76PI3K-Akt signaling pathway_Homo sapiens_hsa041511.10475748
77GABAergic synapse_Homo sapiens_hsa047271.09059855
78Serotonergic synapse_Homo sapiens_hsa047261.09035271
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07896554
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03758599
81Pancreatic cancer_Homo sapiens_hsa052121.03531865
82Glutamatergic synapse_Homo sapiens_hsa047241.03074798
83Calcium signaling pathway_Homo sapiens_hsa040201.02693859
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01112749
85Renal cell carcinoma_Homo sapiens_hsa052110.99984147
86Platelet activation_Homo sapiens_hsa046110.99055921
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97283295
88Melanoma_Homo sapiens_hsa052180.97021817
89Viral myocarditis_Homo sapiens_hsa054160.96529514
90Fatty acid degradation_Homo sapiens_hsa000710.94980369
91Oocyte meiosis_Homo sapiens_hsa041140.93006008
92Lysine degradation_Homo sapiens_hsa003100.92351890
93Pathways in cancer_Homo sapiens_hsa052000.91465534
94Circadian entrainment_Homo sapiens_hsa047130.91245592
95Protein export_Homo sapiens_hsa030600.90246927
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89535713
97Salivary secretion_Homo sapiens_hsa049700.87881789
98Viral carcinogenesis_Homo sapiens_hsa052030.87676396
99Toxoplasmosis_Homo sapiens_hsa051450.87651905
100Apoptosis_Homo sapiens_hsa042100.87352384
101Insulin secretion_Homo sapiens_hsa049110.86846386
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.85632853
103HTLV-I infection_Homo sapiens_hsa051660.84877739
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84162148
105Histidine metabolism_Homo sapiens_hsa003400.84137469
106RNA degradation_Homo sapiens_hsa030180.83707885
107Peroxisome_Homo sapiens_hsa041460.83272467
108VEGF signaling pathway_Homo sapiens_hsa043700.82234396
109Endocytosis_Homo sapiens_hsa041440.81972831
110Epstein-Barr virus infection_Homo sapiens_hsa051690.81879685
111Ovarian steroidogenesis_Homo sapiens_hsa049130.81054149
112Axon guidance_Homo sapiens_hsa043600.80241911
113Basal cell carcinoma_Homo sapiens_hsa052170.78982355
114Prostate cancer_Homo sapiens_hsa052150.78814582
115Arachidonic acid metabolism_Homo sapiens_hsa005900.78523870
116Rap1 signaling pathway_Homo sapiens_hsa040150.76891493
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75114535
118Colorectal cancer_Homo sapiens_hsa052100.75075500
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74974936
120mTOR signaling pathway_Homo sapiens_hsa041500.74858462
121Endometrial cancer_Homo sapiens_hsa052130.74242733
122Regulation of autophagy_Homo sapiens_hsa041400.70855782
123Fatty acid metabolism_Homo sapiens_hsa012120.70771124
124Purine metabolism_Homo sapiens_hsa002300.70619560
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69963135
126Non-small cell lung cancer_Homo sapiens_hsa052230.68106535
127Gap junction_Homo sapiens_hsa045400.67712345
128Circadian rhythm_Homo sapiens_hsa047100.65376306
129Malaria_Homo sapiens_hsa051440.63921820
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63751394
131Salmonella infection_Homo sapiens_hsa051320.63740999
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63582904
133Pyrimidine metabolism_Homo sapiens_hsa002400.62562934
134Spliceosome_Homo sapiens_hsa030400.61350682
135Dorso-ventral axis formation_Homo sapiens_hsa043200.60510200
136One carbon pool by folate_Homo sapiens_hsa006700.58895473
137Acute myeloid leukemia_Homo sapiens_hsa052210.56754046
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.55601999
139Long-term depression_Homo sapiens_hsa047300.54582978
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.54390979
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54224361
142Hepatitis B_Homo sapiens_hsa051610.54192999
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.53995194
144HIF-1 signaling pathway_Homo sapiens_hsa040660.53832577
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53062344
146Carbon metabolism_Homo sapiens_hsa012000.52920688
147FoxO signaling pathway_Homo sapiens_hsa040680.51744508
148Phagosome_Homo sapiens_hsa041450.51236713
149Metabolic pathways_Homo sapiens_hsa011000.50937714
150ErbB signaling pathway_Homo sapiens_hsa040120.49111515
151TNF signaling pathway_Homo sapiens_hsa046680.47540157
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.46059806
153Estrogen signaling pathway_Homo sapiens_hsa049150.44476428
154cAMP signaling pathway_Homo sapiens_hsa040240.43821391
155Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43181331
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42527792
157Nucleotide excision repair_Homo sapiens_hsa034200.42109211
158Wnt signaling pathway_Homo sapiens_hsa043100.41927002
159Steroid biosynthesis_Homo sapiens_hsa001000.41586595
160Legionellosis_Homo sapiens_hsa051340.40989050
161Fat digestion and absorption_Homo sapiens_hsa049750.40013001
162Glutathione metabolism_Homo sapiens_hsa004800.39050501
163Nitrogen metabolism_Homo sapiens_hsa009100.36527329
164GnRH signaling pathway_Homo sapiens_hsa049120.36243823
165Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36229631
166Starch and sucrose metabolism_Homo sapiens_hsa005000.36209239
167Pancreatic secretion_Homo sapiens_hsa049720.36105526
168Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35692045
169Dopaminergic synapse_Homo sapiens_hsa047280.35072951
170N-Glycan biosynthesis_Homo sapiens_hsa005100.35040112
171Vitamin digestion and absorption_Homo sapiens_hsa049770.35032222
172Mismatch repair_Homo sapiens_hsa034300.34300634
173Fatty acid biosynthesis_Homo sapiens_hsa000610.34249622
174Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33827492
175Cysteine and methionine metabolism_Homo sapiens_hsa002700.33799453
176Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33601351
1772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33525347
178Mineral absorption_Homo sapiens_hsa049780.32986731
179Cholinergic synapse_Homo sapiens_hsa047250.31643442
180Intestinal immune network for IgA production_Homo sapiens_hsa046720.30866560
181Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30221301
182AMPK signaling pathway_Homo sapiens_hsa041520.29505569
183Renin secretion_Homo sapiens_hsa049240.28454284
184Collecting duct acid secretion_Homo sapiens_hsa049660.27567359

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