DYNC1H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.52803438
2synaptic vesicle maturation (GO:0016188)4.35193105
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30369157
4locomotory exploration behavior (GO:0035641)4.29643888
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94128139
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.92621431
7establishment of nucleus localization (GO:0040023)3.78458884
8sodium ion export (GO:0071436)3.62198780
9hemidesmosome assembly (GO:0031581)3.45815568
10nuclear pore complex assembly (GO:0051292)3.44488160
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34487675
12dendrite morphogenesis (GO:0048813)3.33178506
13synaptic vesicle docking involved in exocytosis (GO:0016081)3.28863960
14plasma membrane repair (GO:0001778)3.26380682
15regulation of NFAT protein import into nucleus (GO:0051532)3.24759595
16vocalization behavior (GO:0071625)3.21244901
17regulation of ARF protein signal transduction (GO:0032012)3.21208614
18dendritic spine morphogenesis (GO:0060997)3.20746340
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18494825
20activation of protein kinase A activity (GO:0034199)3.13841334
21proline transport (GO:0015824)3.13799984
22cell migration in hindbrain (GO:0021535)3.13236190
23cell communication by electrical coupling (GO:0010644)3.11758934
24cell adhesion mediated by integrin (GO:0033627)3.11703159
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.10245065
26vesicle transport along microtubule (GO:0047496)3.10076438
27cerebellar Purkinje cell differentiation (GO:0021702)3.09871595
28exploration behavior (GO:0035640)3.07358526
29cell-substrate junction assembly (GO:0007044)3.06625007
30glutamate secretion (GO:0014047)3.06472800
31regulation of synaptic vesicle exocytosis (GO:2000300)3.04942707
32regulation of glutamate receptor signaling pathway (GO:1900449)3.00073228
33cellular potassium ion homeostasis (GO:0030007)2.96295629
34regulation of synapse structural plasticity (GO:0051823)2.95023505
35neuromuscular process controlling balance (GO:0050885)2.92750039
36nerve growth factor signaling pathway (GO:0038180)2.90799010
37regulation of clathrin-mediated endocytosis (GO:2000369)2.89054839
38focal adhesion assembly (GO:0048041)2.87866583
39cell-substrate adherens junction assembly (GO:0007045)2.87866583
40paraxial mesoderm development (GO:0048339)2.84932384
41synaptic vesicle exocytosis (GO:0016079)2.84647662
42clathrin coat assembly (GO:0048268)2.83819986
43axonal fasciculation (GO:0007413)2.82522562
44negative regulation of organelle assembly (GO:1902116)2.81023877
45nuclear pore organization (GO:0006999)2.80053477
46organelle transport along microtubule (GO:0072384)2.78718203
47peptidyl-lysine dimethylation (GO:0018027)2.77986214
48skin morphogenesis (GO:0043589)2.75814508
49glucocorticoid receptor signaling pathway (GO:0042921)2.74835600
50protein localization to synapse (GO:0035418)2.73634521
51positive regulation of synapse maturation (GO:0090129)2.73042309
52establishment of protein localization to Golgi (GO:0072600)2.69598599
53cerebellar granule cell differentiation (GO:0021707)2.69400955
54axon extension (GO:0048675)2.68550819
55mating behavior (GO:0007617)2.66612996
56neurotransmitter secretion (GO:0007269)2.65664250
57cerebellar Purkinje cell layer development (GO:0021680)2.64716654
58dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63873267
59protein targeting to Golgi (GO:0000042)2.63859465
60myelination in peripheral nervous system (GO:0022011)2.63726235
61peripheral nervous system axon ensheathment (GO:0032292)2.63726235
62camera-type eye morphogenesis (GO:0048593)2.62025733
63regulation of ARF GTPase activity (GO:0032312)2.61315668
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60662766
65regulation of axon extension involved in axon guidance (GO:0048841)2.60294226
66cell communication involved in cardiac conduction (GO:0086065)2.60227641
67negative regulation of dendrite morphogenesis (GO:0050774)2.59802667
68regulation of neuronal synaptic plasticity (GO:0048168)2.58676211
69macroautophagy (GO:0016236)2.58621065
70insulin-like growth factor receptor signaling pathway (GO:0048009)2.58609154
71neuron recognition (GO:0008038)2.58044641
72pre-miRNA processing (GO:0031054)2.57023889
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56222723
74retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56086527
75membrane depolarization during action potential (GO:0086010)2.55960240
76embryonic retina morphogenesis in camera-type eye (GO:0060059)2.55762218
77apical protein localization (GO:0045176)2.54932433
78nucleus localization (GO:0051647)2.53149014
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52993577
80axon cargo transport (GO:0008088)2.52475147
81regulation of synaptic vesicle transport (GO:1902803)2.51537526
82regulation of nucleobase-containing compound transport (GO:0032239)2.51112229
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49342251
84pore complex assembly (GO:0046931)2.48120754
85regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46327242
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45338703
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.44688297
88regulation of dendritic spine morphogenesis (GO:0061001)2.44404990
89COPI coating of Golgi vesicle (GO:0048205)2.44226296
90Golgi transport vesicle coating (GO:0048200)2.44226296
91neural tube development (GO:0021915)2.43946088
92central nervous system projection neuron axonogenesis (GO:0021952)2.43716993
93neuron projection extension (GO:1990138)2.43586957
94developmental cell growth (GO:0048588)2.43246015
95synaptic vesicle endocytosis (GO:0048488)2.40981325
96regulation of RNA export from nucleus (GO:0046831)2.40933137
97innervation (GO:0060384)2.40659247
98morphogenesis of an epithelial sheet (GO:0002011)2.40628879
99positive regulation of axon extension (GO:0045773)2.39991087
100myoblast fusion (GO:0007520)2.39491339
101NLS-bearing protein import into nucleus (GO:0006607)2.38258835
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38257451
103protein localization to endosome (GO:0036010)2.37675930
104peptidyl-threonine phosphorylation (GO:0018107)2.37638475
105protein retention in ER lumen (GO:0006621)2.37543453
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.37385821
107hippo signaling (GO:0035329)2.37090800
108establishment of spindle localization (GO:0051293)2.36688928
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36502857
110cortical actin cytoskeleton organization (GO:0030866)2.36483846
111glial cell proliferation (GO:0014009)2.35907535
112membrane assembly (GO:0071709)2.34852381
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.34437007
114amino acid import (GO:0043090)2.33833010
115protein targeting to plasma membrane (GO:0072661)2.33723809
116negative regulation of cell size (GO:0045792)2.33390421
117asymmetric protein localization (GO:0008105)2.33343921
118regulation of protein polyubiquitination (GO:1902914)2.32666130
119establishment of spindle orientation (GO:0051294)2.32194722
120negative regulation of fatty acid transport (GO:2000192)2.30655656
121positive regulation of fibroblast migration (GO:0010763)2.30591571
122potassium ion import (GO:0010107)2.30487389
123gamma-aminobutyric acid transport (GO:0015812)2.30365973
124activation of Rac GTPase activity (GO:0032863)2.29559543
125peptidyl-threonine modification (GO:0018210)2.29399506
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.29314884
127negative regulation of potassium ion transmembrane transport (GO:1901380)2.29257136
128establishment of mitochondrion localization (GO:0051654)2.29100118
129neuron cell-cell adhesion (GO:0007158)2.29006752
130alanine transport (GO:0032328)2.27825756
131regulation of axon guidance (GO:1902667)2.26596295
132response to nerve growth factor (GO:1990089)2.26564273
133cellular response to nerve growth factor stimulus (GO:1990090)2.26564273
134axon extension involved in axon guidance (GO:0048846)2.24804369
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.24804369
136establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.23667088
137mitochondrion transport along microtubule (GO:0047497)2.23667088
138regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.23541916
139prepulse inhibition (GO:0060134)2.22703539
140semaphorin-plexin signaling pathway (GO:0071526)2.22437260
141adherens junction organization (GO:0034332)2.21696916
142dendritic spine organization (GO:0097061)2.21587539
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.20395902
144glycine transport (GO:0015816)2.19917378
145syncytium formation by plasma membrane fusion (GO:0000768)2.19311117
146cellular sodium ion homeostasis (GO:0006883)2.18869407
147neuronal ion channel clustering (GO:0045161)2.17680806
148mitotic cytokinesis (GO:0000281)2.17294033
149G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16714325
150adherens junction assembly (GO:0034333)2.15943494
151corticosteroid receptor signaling pathway (GO:0031958)2.15815837
152retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15678472
153suckling behavior (GO:0001967)2.15535222
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.15012034
155cortical cytoskeleton organization (GO:0030865)2.14991182
156cytoskeleton-dependent cytokinesis (GO:0061640)2.14417145
157postsynaptic membrane organization (GO:0001941)2.14046036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97848906
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.27332568
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.78617337
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.68112976
5DROSHA_22980978_ChIP-Seq_HELA_Human2.53749849
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.11604521
7STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95563714
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91040952
9KDM2B_26808549_Chip-Seq_K562_Human1.82667245
10CLOCK_20551151_ChIP-Seq_293T_Human1.79496711
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79164369
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78909342
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.75658077
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75151055
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75144331
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72936857
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71020122
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71020122
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70134041
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69919231
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67071972
22REST_21632747_ChIP-Seq_MESCs_Mouse1.66344944
23GBX2_23144817_ChIP-Seq_PC3_Human1.65993305
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65238539
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63777386
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63741355
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63457122
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61354009
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61187032
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60770621
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59864467
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.58570101
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.56103980
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.54919907
35KDM2B_26808549_Chip-Seq_DND41_Human1.53502780
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52317448
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51708733
38* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50217541
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49001449
40WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47911645
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47735211
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46533380
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44056199
44AHR_22903824_ChIP-Seq_MCF-7_Human1.42211228
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41268155
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41126793
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.39224929
48ZNF274_21170338_ChIP-Seq_K562_Hela1.38829204
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.37659522
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37282483
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36981341
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35013430
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.34291426
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33820951
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32713225
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.31232814
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30925372
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.29677314
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.29391064
60TP53_16413492_ChIP-PET_HCT116_Human1.28746412
61AR_19668381_ChIP-Seq_PC3_Human1.28472288
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28247400
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27481197
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26718812
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.26710650
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26650580
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26141565
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26020792
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24696832
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22900569
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22040360
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20964606
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.20807180
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20594924
75TP53_23651856_ChIP-Seq_MEFs_Mouse1.19764800
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.18257862
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17991641
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17532173
79AR_21572438_ChIP-Seq_LNCaP_Human1.16097164
80SMAD4_21799915_ChIP-Seq_A2780_Human1.15439936
81E2F7_22180533_ChIP-Seq_HELA_Human1.15280303
82* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14830339
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.14554659
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14534319
85TP53_22127205_ChIP-Seq_IMR90_Human1.12946173
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.12467464
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12340500
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.11485003
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11056906
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.09387807
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09319588
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08297196
93* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08124967
94* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07933447
95* STAT3_23295773_ChIP-Seq_U87_Human1.07783313
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07591115
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07550451
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07550451
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.07082146
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.07082146
101ZNF263_19887448_ChIP-Seq_K562_Human1.07001639
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06908001
103AR_21909140_ChIP-Seq_LNCAP_Human1.06232798
104* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06214525
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.05745841
106* RACK7_27058665_Chip-Seq_MCF-7_Human1.05430708
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.05361058
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05306773
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04896335
110SMAD3_21741376_ChIP-Seq_ESCs_Human1.04652140
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04382839
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03673030
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.02959587
114TCF7_22412390_ChIP-Seq_EML_Mouse1.02933690
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02735969
116* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02463961
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02357494
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01318851
119* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01103805
120SMAD_19615063_ChIP-ChIP_OVARY_Human1.00932731
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99747426
122EED_16625203_ChIP-ChIP_MESCs_Mouse0.98568183
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98323648
124TCF4_23295773_ChIP-Seq_U87_Human0.98225000
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97307992
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96177191
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95748217
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.95246951
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93050304
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.92808732
131CREB1_26743006_Chip-Seq_LNCaP_Human0.92670135
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91559724
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90718768
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90659857
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.89158918
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.88732764
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85099395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.12210700
2MP0000569_abnormal_digit_pigmentation4.55659779
3MP0004270_analgesia3.04241973
4MP0009780_abnormal_chondrocyte_physiolo2.82920013
5MP0005409_darkened_coat_color2.75450614
6MP0003635_abnormal_synaptic_transmissio2.73559778
7MP0004858_abnormal_nervous_system2.67628508
8MP0003705_abnormal_hypodermis_morpholog2.42723916
9MP0005623_abnormal_meninges_morphology2.39390363
10MP0003283_abnormal_digestive_organ2.23048806
11MP0002063_abnormal_learning/memory/cond2.12701769
12MP0005257_abnormal_intraocular_pressure2.06364790
13MP0010234_abnormal_vibrissa_follicle2.00088674
14MP0000751_myopathy1.95157804
15MP0005076_abnormal_cell_differentiation1.94731686
16MP0000778_abnormal_nervous_system1.89166273
17MP0003045_fibrosis1.88769157
18MP0005423_abnormal_somatic_nervous1.87239251
19MP0008961_abnormal_basal_metabolism1.83098273
20* MP0009046_muscle_twitch1.75109937
21MP0009745_abnormal_behavioral_response1.74408350
22MP0002734_abnormal_mechanical_nocicepti1.73893856
23MP0002064_seizures1.71625861
24MP0002909_abnormal_adrenal_gland1.68039856
25* MP0004811_abnormal_neuron_physiology1.66651836
26MP0004233_abnormal_muscle_weight1.62639714
27MP0001299_abnormal_eye_distance/1.62506026
28MP0003329_amyloid_beta_deposits1.62423404
29MP0003880_abnormal_central_pattern1.61612143
30MP0004885_abnormal_endolymph1.58528523
31MP0003787_abnormal_imprinting1.55754367
32MP0003385_abnormal_body_wall1.53816706
33MP0000579_abnormal_nail_morphology1.53244240
34MP0002572_abnormal_emotion/affect_behav1.47194608
35MP0001968_abnormal_touch/_nociception1.41631176
36MP0001486_abnormal_startle_reflex1.39024476
37MP0010352_gastrointestinal_tract_polyps1.37698339
38MP0002733_abnormal_thermal_nociception1.36689565
39* MP0000955_abnormal_spinal_cord1.36380262
40MP0000537_abnormal_urethra_morphology1.35579242
41MP0010368_abnormal_lymphatic_system1.31619481
42MP0003091_abnormal_cell_migration1.29603555
43MP0003300_gastrointestinal_ulcer1.29459774
44MP0005275_abnormal_skin_tensile1.28825548
45MP0008569_lethality_at_weaning1.27712604
46* MP0002184_abnormal_innervation1.24676641
47MP0003172_abnormal_lysosome_physiology1.24032135
48MP0001440_abnormal_grooming_behavior1.22031786
49MP0004130_abnormal_muscle_cell1.20344299
50MP0005187_abnormal_penis_morphology1.19400583
51MP0002272_abnormal_nervous_system1.15879992
52MP0002735_abnormal_chemical_nociception1.15418516
53* MP0002882_abnormal_neuron_morphology1.14833235
54MP0002009_preneoplasia1.14828778
55MP0003123_paternal_imprinting1.14559611
56MP0002152_abnormal_brain_morphology1.14160105
57MP0000733_abnormal_muscle_development1.13811736
58MP0003942_abnormal_urinary_system1.13354403
59MP0004924_abnormal_behavior1.10293861
60MP0005386_behavior/neurological_phenoty1.10293861
61MP0003633_abnormal_nervous_system1.09306594
62MP0001849_ear_inflammation1.09029784
63MP0002067_abnormal_sensory_capabilities1.07909890
64MP0003950_abnormal_plasma_membrane1.06488823
65MP0008438_abnormal_cutaneous_collagen1.06414490
66MP0003941_abnormal_skin_development1.06373263
67MP0002653_abnormal_ependyma_morphology1.06338159
68MP0001348_abnormal_lacrimal_gland1.06312812
69MP0001915_intracranial_hemorrhage1.06300727
70MP0001970_abnormal_pain_threshold1.06051335
71MP0002557_abnormal_social/conspecific_i1.03731346
72MP0003632_abnormal_nervous_system1.02703801
73MP0002697_abnormal_eye_size1.02636356
74MP0004145_abnormal_muscle_electrophysio1.01884410
75MP0004087_abnormal_muscle_fiber1.01332895
76MP0005410_abnormal_fertilization1.00709846
77MP0004084_abnormal_cardiac_muscle1.00515207
78MP0008877_abnormal_DNA_methylation1.00251376
79MP0000462_abnormal_digestive_system0.99548398
80MP0003631_nervous_system_phenotype0.98285992
81MP0000762_abnormal_tongue_morphology0.98274896
82MP0003861_abnormal_nervous_system0.97294415
83MP0000003_abnormal_adipose_tissue0.96279359
84* MP0003634_abnormal_glial_cell0.95662050
85MP0003935_abnormal_craniofacial_develop0.94589610
86MP0000534_abnormal_ureter_morphology0.93648942
87MP0002060_abnormal_skin_morphology0.92819499
88MP0000759_abnormal_skeletal_muscle0.90638135
89MP0004510_myositis0.90429199
90* MP0002066_abnormal_motor_capabilities/c0.89195620
91MP0001958_emphysema0.88945359
92MP0000566_synostosis0.87179861
93MP0002084_abnormal_developmental_patter0.87065837
94* MP0002081_perinatal_lethality0.86867318
95MP0009053_abnormal_anal_canal0.86692286
96MP0000747_muscle_weakness0.86615628
97MP0003115_abnormal_respiratory_system0.86457760
98MP0009672_abnormal_birth_weight0.85900326
99MP0002092_abnormal_eye_morphology0.85819348
100MP0000013_abnormal_adipose_tissue0.85810326
101MP0000749_muscle_degeneration0.85417248
102MP0006138_congestive_heart_failure0.85411670
103MP0000604_amyloidosis0.84513122
104MP0001879_abnormal_lymphatic_vessel0.83452399
105MP0005248_abnormal_Harderian_gland0.82935779
106MP0003453_abnormal_keratinocyte_physiol0.82044506
107MP0002822_catalepsy0.81570943
108MP0003879_abnormal_hair_cell0.81168433
109MP0010307_abnormal_tumor_latency0.80756938
110MP0002837_dystrophic_cardiac_calcinosis0.80721589
111MP0010030_abnormal_orbit_morphology0.80244035
112MP0002877_abnormal_melanocyte_morpholog0.79760465
113MP0005023_abnormal_wound_healing0.79724734
114MP0005375_adipose_tissue_phenotype0.79233513
115MP0003566_abnormal_cell_adhesion0.79211374
116MP0000432_abnormal_head_morphology0.79168367
117MP0002089_abnormal_postnatal_growth/wei0.78988432
118MP0001177_atelectasis0.78869926
119MP0001501_abnormal_sleep_pattern0.78829526
120MP0003690_abnormal_glial_cell0.77393810
121MP0000920_abnormal_myelination0.77204990
122MP0002269_muscular_atrophy0.76611533
123MP0003937_abnormal_limbs/digits/tail_de0.76476193
124MP0003122_maternal_imprinting0.76186046
125MP0002234_abnormal_pharynx_morphology0.75960903
126MP0002896_abnormal_bone_mineralization0.75848840
127MP0005167_abnormal_blood-brain_barrier0.75773987
128MP0002108_abnormal_muscle_morphology0.75514908
129MP0004085_abnormal_heartbeat0.74754541
130MP0004272_abnormal_basement_membrane0.73525923
131MP0000428_abnormal_craniofacial_morphol0.73157256
132MP0004185_abnormal_adipocyte_glucose0.73071567
133MP0003890_abnormal_embryonic-extraembry0.72827454
134MP0003303_peritoneal_inflammation0.72032793
135MP0010630_abnormal_cardiac_muscle0.70989304
136MP0005621_abnormal_cell_physiology0.70934589
137MP0008770_decreased_survivor_rate0.69861383
138MP0002114_abnormal_axial_skeleton0.69725743
139MP0003755_abnormal_palate_morphology0.68770533
140MP0003121_genomic_imprinting0.68432875
141MP0001730_embryonic_growth_arrest0.68374251
142MP0004197_abnormal_fetal_growth/weight/0.67713770
143MP0002116_abnormal_craniofacial_bone0.67373116
144MP0002086_abnormal_extraembryonic_tissu0.67168725

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)3.46260712
2Premature rupture of membranes (HP:0001788)3.21258778
3Macroorchidism (HP:0000053)3.11608445
4Protrusio acetabuli (HP:0003179)3.11333329
5Hyperacusis (HP:0010780)3.08072127
6Cerebral aneurysm (HP:0004944)2.89239413
7Insidious onset (HP:0003587)2.83980876
8Termporal pattern (HP:0011008)2.83980876
9Supranuclear gaze palsy (HP:0000605)2.83588846
10Atrophic scars (HP:0001075)2.80048744
11Myokymia (HP:0002411)2.73770339
12Shallow orbits (HP:0000586)2.71550464
13Action tremor (HP:0002345)2.71263442
14Urinary bladder sphincter dysfunction (HP:0002839)2.62075767
15Broad face (HP:0000283)2.57230461
16Elfin facies (HP:0004428)2.56703020
17Insomnia (HP:0100785)2.56605122
18Distal upper limb amyotrophy (HP:0007149)2.56418413
19Upper limb amyotrophy (HP:0009129)2.56418413
20Arterial tortuosity (HP:0005116)2.51623795
21Ulnar bowing (HP:0003031)2.49046231
22Heterotopia (HP:0002282)2.45674489
23Astrocytoma (HP:0009592)2.44724294
24Abnormality of the astrocytes (HP:0100707)2.44724294
25Hand muscle atrophy (HP:0009130)2.43114918
26Visual hallucinations (HP:0002367)2.41805499
27Ankle clonus (HP:0011448)2.41779192
28Urinary urgency (HP:0000012)2.41340958
29Lower limb amyotrophy (HP:0007210)2.40859275
30Pointed chin (HP:0000307)2.38613320
31Renovascular hypertension (HP:0100817)2.38213817
32Dysmetric saccades (HP:0000641)2.33918657
33Vascular tortuosity (HP:0004948)2.33223340
34Short nail (HP:0001799)2.33141184
35Vertebral arch anomaly (HP:0008438)2.30089984
36Genetic anticipation (HP:0003743)2.29205923
37Amyotrophic lateral sclerosis (HP:0007354)2.27136681
38Bowel diverticulosis (HP:0005222)2.22746710
39* Focal seizures (HP:0007359)2.22634541
40Obstructive sleep apnea (HP:0002870)2.21642988
41Impaired vibration sensation in the lower limbs (HP:0002166)2.19895360
42Abnormality of the corticospinal tract (HP:0002492)2.19447816
43Cerebral inclusion bodies (HP:0100314)2.18980403
44Distal lower limb amyotrophy (HP:0008944)2.15009511
45Aqueductal stenosis (HP:0002410)2.13998194
46Abnormality of the distal phalanx of the thumb (HP:0009617)2.13542632
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12634718
48Short 4th metacarpal (HP:0010044)2.12634718
49Absent frontal sinuses (HP:0002688)2.12432711
50Progressive cerebellar ataxia (HP:0002073)2.11371725
51Wormian bones (HP:0002645)2.10989990
52Overriding aorta (HP:0002623)2.10818360
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.08654234
54Osteolytic defects of the hand bones (HP:0009699)2.08593812
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.08593812
56Subacute progressive viral hepatitis (HP:0006572)2.07651892
57Postural instability (HP:0002172)2.01957784
58Fragile skin (HP:0001030)2.00299982
59Bronchomalacia (HP:0002780)1.99619930
60Focal motor seizures (HP:0011153)1.98560031
61Spinal rigidity (HP:0003306)1.97708347
62Hemiplegia (HP:0002301)1.97613213
63Bladder diverticulum (HP:0000015)1.95562222
64Neoplasm of the heart (HP:0100544)1.94781816
65Renal duplication (HP:0000075)1.93849766
66Papilledema (HP:0001085)1.93701936
67Narrow palate (HP:0000189)1.92874488
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92671656
69Mitral regurgitation (HP:0001653)1.91557398
70Lower limb muscle weakness (HP:0007340)1.90959468
71Aplasia involving bones of the upper limbs (HP:0009823)1.90822133
72Aplasia of the phalanges of the hand (HP:0009802)1.90822133
73Aplasia involving bones of the extremities (HP:0009825)1.90822133
74Impaired smooth pursuit (HP:0007772)1.90673466
75Excessive salivation (HP:0003781)1.90639776
76Drooling (HP:0002307)1.90639776
77Aortic dissection (HP:0002647)1.90522166
78Flat cornea (HP:0007720)1.89742941
79Abnormality of ocular smooth pursuit (HP:0000617)1.88802308
80Truncal ataxia (HP:0002078)1.88553056
81Increased connective tissue (HP:0009025)1.87064750
82Depression (HP:0000716)1.86439242
83Resting tremor (HP:0002322)1.85896404
84Neonatal short-limb short stature (HP:0008921)1.83642636
85Bundle branch block (HP:0011710)1.82482876
86Spastic gait (HP:0002064)1.82471930
87Obsessive-compulsive behavior (HP:0000722)1.81908308
88Inappropriate behavior (HP:0000719)1.81581775
89Impaired social interactions (HP:0000735)1.81281191
90Abnormal social behavior (HP:0012433)1.81281191
91Hammertoe (HP:0001765)1.80584979
92Gaze-evoked nystagmus (HP:0000640)1.78778782
93Wide anterior fontanel (HP:0000260)1.77833843
94Precocious puberty (HP:0000826)1.77596211
95Arnold-Chiari malformation (HP:0002308)1.77379769
96Broad metatarsal (HP:0001783)1.77373245
97Cubitus valgus (HP:0002967)1.76567589
98Scanning speech (HP:0002168)1.75631996
99Relative macrocephaly (HP:0004482)1.75594783
100Buphthalmos (HP:0000557)1.74459574
101Apathy (HP:0000741)1.74220993
102Patellar dislocation (HP:0002999)1.73707323
103Mutism (HP:0002300)1.73415971
104Urethral obstruction (HP:0000796)1.73367861
105Lymphangioma (HP:0100764)1.71982138
106Enlarged penis (HP:0000040)1.71746908
107Aortic aneurysm (HP:0004942)1.70656019
108Disproportionate tall stature (HP:0001519)1.70500875
109Overgrowth (HP:0001548)1.70346856
110Genu recurvatum (HP:0002816)1.69827705
111Turricephaly (HP:0000262)1.69133751
112Epileptic encephalopathy (HP:0200134)1.68325617
113Flat acetabular roof (HP:0003180)1.67780183
114Asymmetry of the thorax (HP:0001555)1.67763945
115Mitral valve prolapse (HP:0001634)1.67156298
116Aneurysm (HP:0002617)1.66989014
117Dysdiadochokinesis (HP:0002075)1.66919097
118Ankyloglossia (HP:0010296)1.66058069
119Abnormality of the calcaneus (HP:0008364)1.65653297
120Intellectual disability, profound (HP:0002187)1.64517236
121Long eyelashes (HP:0000527)1.64257726
122Abnormality of the 4th metacarpal (HP:0010012)1.63749293
123Advanced eruption of teeth (HP:0006288)1.63563787
124Ankle contracture (HP:0006466)1.63444752
125Rapidly progressive (HP:0003678)1.62158198
126Sacral dimple (HP:0000960)1.61772220
127Hypopigmentation of the fundus (HP:0007894)1.61600844
128Scapular winging (HP:0003691)1.61551151
129Poor eye contact (HP:0000817)1.61162423
130Open mouth (HP:0000194)1.61106321
131Cervical subluxation (HP:0003308)1.60853133
132Abnormality of dentin (HP:0010299)1.59819908
133Glioma (HP:0009733)1.59760229
134Hyperextensible skin (HP:0000974)1.58965536
135Missing ribs (HP:0000921)1.58836007
136Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.58645993
137Hypoventilation (HP:0002791)1.58528239
138Fibroma (HP:0010614)1.58466314
139Intention tremor (HP:0002080)1.58370172
140Neurofibrillary tangles (HP:0002185)1.57892323
141Neuronal loss in central nervous system (HP:0002529)1.57679644
142Papillary thyroid carcinoma (HP:0002895)1.57387004
143Ventricular fibrillation (HP:0001663)1.57310606
144High anterior hairline (HP:0009890)1.56861630
145Dislocated radial head (HP:0003083)1.56399208
146Joint laxity (HP:0001388)1.56381073
147Difficulty climbing stairs (HP:0003551)1.56068950
148Fibrous tissue neoplasm (HP:0012316)1.55873655
149Long palpebral fissure (HP:0000637)1.55090545
150Abnormality of oral frenula (HP:0000190)1.54315504
151Hamartoma of the eye (HP:0010568)1.53881322
152Hemiparesis (HP:0001269)1.53822803
153Mildly elevated creatine phosphokinase (HP:0008180)1.52784485
154Natal tooth (HP:0000695)1.52689120
155Deep palmar crease (HP:0006191)1.50809718
156Increased nuchal translucency (HP:0010880)1.49301972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.18901055
2MAP3K93.13302345
3PRKD32.40280650
4NTRK32.32812084
5TRIB32.30908154
6CAMK1G2.29648635
7RIPK12.29643575
8CDK122.23118853
9PAK62.22287312
10MAP3K42.15285435
11ICK2.04786697
12MST1R1.86465356
13SCYL21.83996330
14TTN1.82811182
15CAMK1D1.81481481
16MET1.76617977
17PKN21.75820445
18NTRK11.75576435
19CASK1.74944584
20TYRO31.73837184
21CAMKK11.66449028
22MINK11.66315655
23PDGFRA1.64644917
24SIK21.64009942
25KSR21.63287944
26DAPK21.62730970
27NTRK21.59974990
28EPHA21.59414771
29LMTK21.57394397
30SMG11.49333430
31PNCK1.46926075
32EEF2K1.43715033
33RET1.39401936
34EPHA41.38343642
35LATS21.35984530
36STK381.34310057
37MAP3K21.28965321
38PHKG21.25027893
39PHKG11.25027893
40KSR11.24794518
41PDK31.23572780
42PDK41.23572780
43AKT31.23383671
44ALK1.19612222
45FGFR21.15436477
46MAP3K101.13271722
47PTK61.12477124
48MTOR1.09217734
49CDK51.06065647
50WNK11.06011000
51DDR21.05722851
52DMPK1.03041494
53MARK21.02190134
54PRKCH1.01815642
55FGFR41.01404060
56PAK31.00604001
57PDGFRB0.94740012
58TAOK10.94334130
59SGK30.94263958
60STK110.92214069
61CDC42BPA0.91620604
62LATS10.91522249
63SIK10.90729079
64PRPF4B0.87929628
65BMX0.86886685
66BRD40.82652317
67MAP2K40.81782654
68PTK20.81664347
69ERBB40.80422298
70FER0.76579518
71MAP3K60.76404666
72PTK2B0.74423080
73RPS6KA20.74051205
74MAP3K70.73401689
75MOS0.70035488
76FGFR30.65306700
77SGK10.64593308
78CAMK2B0.64467379
79UHMK10.62978422
80CDK11A0.61089581
81ROCK20.60774959
82PAK20.60163211
83FGFR10.58238065
84PDK10.57683835
85SGK4940.57293630
86SGK2230.57293630
87SGK20.56298832
88ROCK10.54971851
89ERBB20.54262057
90RPS6KA30.53190238
91MAPK100.53092717
92PRKAA10.51270812
93BRAF0.50959982
94FYN0.50299797
95CSNK1G20.50243730
96EPHB20.49125852
97PDPK10.49083109
98EPHB10.48713807
99PDK20.48165749
100CSNK1D0.47439695
101JAK10.47412275
102MAPK80.47054313
103CDK150.46692432
104IRAK30.45980096
105TRPM70.45855894
106BRSK10.44922819
107ARAF0.44503988
108NEK90.43767888
109CDK60.43098030
110NEK10.42583032
111CDK180.42430315
112PRKCZ0.42225828
113RIPK40.41222809
114PRKD10.41029679
115DAPK10.40587971
116GSK3B0.39258836
117CAMK40.38943846
118MAPK130.38899085
119NEK60.38162072
120SRC0.37736330
121CDK140.37604714
122PRKDC0.36860746
123CAMK10.35468612
124CAMK2G0.35165841
125PAK40.35055560
126MELK0.34825540
127CSNK1E0.34749786
128RPS6KB10.34354042

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05884562
2Synaptic vesicle cycle_Homo sapiens_hsa047211.86552817
3Long-term potentiation_Homo sapiens_hsa047201.74210259
4Type II diabetes mellitus_Homo sapiens_hsa049301.71399216
5Circadian entrainment_Homo sapiens_hsa047131.68642617
6Dorso-ventral axis formation_Homo sapiens_hsa043201.67020976
7Olfactory transduction_Homo sapiens_hsa047401.63528899
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56603182
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51856690
10Salivary secretion_Homo sapiens_hsa049701.48712332
11Glioma_Homo sapiens_hsa052141.47646257
12Glutamatergic synapse_Homo sapiens_hsa047241.47098857
13Gastric acid secretion_Homo sapiens_hsa049711.46860951
14Nicotine addiction_Homo sapiens_hsa050331.44611834
15Dopaminergic synapse_Homo sapiens_hsa047281.42927063
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42518727
17Insulin secretion_Homo sapiens_hsa049111.42214649
18Estrogen signaling pathway_Homo sapiens_hsa049151.42061337
19GABAergic synapse_Homo sapiens_hsa047271.41316978
20Cholinergic synapse_Homo sapiens_hsa047251.40508378
21mTOR signaling pathway_Homo sapiens_hsa041501.39556241
22Renin secretion_Homo sapiens_hsa049241.35997509
23Morphine addiction_Homo sapiens_hsa050321.33975183
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32025727
25Amphetamine addiction_Homo sapiens_hsa050311.31827031
26Thyroid cancer_Homo sapiens_hsa052161.30861281
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30556636
28Axon guidance_Homo sapiens_hsa043601.30450585
29Oxytocin signaling pathway_Homo sapiens_hsa049211.29073382
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26963480
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24247625
32GnRH signaling pathway_Homo sapiens_hsa049121.23846567
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23788044
34Endometrial cancer_Homo sapiens_hsa052131.23721312
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23662031
36Gap junction_Homo sapiens_hsa045401.23538846
37ErbB signaling pathway_Homo sapiens_hsa040121.19345763
38Dilated cardiomyopathy_Homo sapiens_hsa054141.18640894
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14151411
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.11748478
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09378981
42* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09370057
43Prion diseases_Homo sapiens_hsa050201.07881042
44Small cell lung cancer_Homo sapiens_hsa052221.06806665
45Notch signaling pathway_Homo sapiens_hsa043301.06650630
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.05764022
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04261522
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03619597
49cAMP signaling pathway_Homo sapiens_hsa040241.03093253
50Melanogenesis_Homo sapiens_hsa049161.02750431
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02331403
52Cocaine addiction_Homo sapiens_hsa050301.02053798
53Focal adhesion_Homo sapiens_hsa045101.01818223
54Bladder cancer_Homo sapiens_hsa052191.01516511
55Long-term depression_Homo sapiens_hsa047300.99780161
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99279998
57VEGF signaling pathway_Homo sapiens_hsa043700.98858490
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97531098
59Renal cell carcinoma_Homo sapiens_hsa052110.95559149
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.95215998
61Proteoglycans in cancer_Homo sapiens_hsa052050.92900315
62Insulin signaling pathway_Homo sapiens_hsa049100.92766578
63Chronic myeloid leukemia_Homo sapiens_hsa052200.92696235
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92301482
65Prostate cancer_Homo sapiens_hsa052150.91101235
66Calcium signaling pathway_Homo sapiens_hsa040200.90400822
67Non-small cell lung cancer_Homo sapiens_hsa052230.89965040
68Nitrogen metabolism_Homo sapiens_hsa009100.89734494
69Glucagon signaling pathway_Homo sapiens_hsa049220.89097668
70Taste transduction_Homo sapiens_hsa047420.87566268
71Colorectal cancer_Homo sapiens_hsa052100.86556894
72Adherens junction_Homo sapiens_hsa045200.86492473
73Oocyte meiosis_Homo sapiens_hsa041140.85133997
74Choline metabolism in cancer_Homo sapiens_hsa052310.84471044
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82948003
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82873701
77Lysine degradation_Homo sapiens_hsa003100.81248925
78Endocytosis_Homo sapiens_hsa041440.80213402
79Melanoma_Homo sapiens_hsa052180.79959730
80Tight junction_Homo sapiens_hsa045300.79777003
81MAPK signaling pathway_Homo sapiens_hsa040100.79730652
82Insulin resistance_Homo sapiens_hsa049310.79404404
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79353993
84Rap1 signaling pathway_Homo sapiens_hsa040150.79144407
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.78693261
86Inositol phosphate metabolism_Homo sapiens_hsa005620.76009242
87AMPK signaling pathway_Homo sapiens_hsa041520.75355703
88Thyroid hormone synthesis_Homo sapiens_hsa049180.74645929
89Basal cell carcinoma_Homo sapiens_hsa052170.74227116
90Hippo signaling pathway_Homo sapiens_hsa043900.72792103
91Pathways in cancer_Homo sapiens_hsa052000.72542661
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72395558
93Amoebiasis_Homo sapiens_hsa051460.72102617
94Fatty acid biosynthesis_Homo sapiens_hsa000610.70244347
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70224687
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69468106
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69197808
98ECM-receptor interaction_Homo sapiens_hsa045120.68995851
99MicroRNAs in cancer_Homo sapiens_hsa052060.68113208
100Hedgehog signaling pathway_Homo sapiens_hsa043400.67331679
101Serotonergic synapse_Homo sapiens_hsa047260.67106231
102Prolactin signaling pathway_Homo sapiens_hsa049170.66030309
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65864553
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64608921
105Pancreatic secretion_Homo sapiens_hsa049720.64290109
106Acute myeloid leukemia_Homo sapiens_hsa052210.63488884
107Pancreatic cancer_Homo sapiens_hsa052120.63449173
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63336051
109Wnt signaling pathway_Homo sapiens_hsa043100.63294589
110Vibrio cholerae infection_Homo sapiens_hsa051100.63214041
111Viral myocarditis_Homo sapiens_hsa054160.62653295
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62419343
113Platelet activation_Homo sapiens_hsa046110.61481465
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.60257876
115Ras signaling pathway_Homo sapiens_hsa040140.60013729
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.58605682
117Bile secretion_Homo sapiens_hsa049760.58534974

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