DYNC1I1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83937643
2synaptic vesicle exocytosis (GO:0016079)5.64682956
3vocalization behavior (GO:0071625)5.51254738
4glutamate secretion (GO:0014047)5.21715154
5neuron cell-cell adhesion (GO:0007158)5.14927590
6synaptic vesicle maturation (GO:0016188)5.14011625
7regulation of synaptic vesicle exocytosis (GO:2000300)5.08313322
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99827352
9locomotory exploration behavior (GO:0035641)4.91253893
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.90795770
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83287413
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.72902902
13regulation of glutamate receptor signaling pathway (GO:1900449)4.69738596
14protein localization to synapse (GO:0035418)4.69733499
15neuronal action potential propagation (GO:0019227)4.68207895
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59035003
17neurotransmitter secretion (GO:0007269)4.56405281
18regulation of synaptic vesicle transport (GO:1902803)4.49349627
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.36111811
20sodium ion export (GO:0071436)4.29787969
21neurotransmitter-gated ion channel clustering (GO:0072578)4.25586857
22exploration behavior (GO:0035640)4.25220572
23neuron-neuron synaptic transmission (GO:0007270)4.13030535
24synaptic transmission, glutamatergic (GO:0035249)4.05581095
25glutamate receptor signaling pathway (GO:0007215)4.05468765
26proline transport (GO:0015824)4.02986362
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90034828
28gamma-aminobutyric acid transport (GO:0015812)3.89313088
29regulation of neuronal synaptic plasticity (GO:0048168)3.87361309
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86302671
31detection of calcium ion (GO:0005513)3.82497967
32presynaptic membrane assembly (GO:0097105)3.82349014
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.81128557
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80811287
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.77007902
36neuronal ion channel clustering (GO:0045161)3.76128766
37postsynaptic membrane organization (GO:0001941)3.75599326
38neurotransmitter transport (GO:0006836)3.73091070
39regulation of synapse structural plasticity (GO:0051823)3.71573903
40positive regulation of synapse maturation (GO:0090129)3.69680015
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.67470929
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60639272
43presynaptic membrane organization (GO:0097090)3.58436993
44L-amino acid import (GO:0043092)3.57620125
45neuron recognition (GO:0008038)3.57608321
46regulation of voltage-gated calcium channel activity (GO:1901385)3.54455929
47negative regulation of dendrite morphogenesis (GO:0050774)3.54287934
48long-term synaptic potentiation (GO:0060291)3.53929680
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.51812202
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47738958
51potassium ion homeostasis (GO:0055075)3.46660298
52regulation of neurotransmitter levels (GO:0001505)3.46328819
53synaptic vesicle endocytosis (GO:0048488)3.46179607
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.45832937
55regulation of neurotransmitter secretion (GO:0046928)3.44888609
56regulation of postsynaptic membrane potential (GO:0060078)3.44238851
57layer formation in cerebral cortex (GO:0021819)3.40792877
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36973994
59cerebellar Purkinje cell differentiation (GO:0021702)3.36814310
60positive regulation of membrane potential (GO:0045838)3.35310144
61long-term memory (GO:0007616)3.34650148
62regulation of synaptic plasticity (GO:0048167)3.34399021
63potassium ion import (GO:0010107)3.33389530
64regulation of dendritic spine morphogenesis (GO:0061001)3.31064006
65activation of protein kinase A activity (GO:0034199)3.30901769
66cerebellar granule cell differentiation (GO:0021707)3.29514646
67positive regulation of dendritic spine development (GO:0060999)3.28562708
68membrane depolarization during action potential (GO:0086010)3.27654547
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25939237
70behavioral fear response (GO:0001662)3.25416619
71behavioral defense response (GO:0002209)3.25416619
72cell migration in hindbrain (GO:0021535)3.23112740
73cellular potassium ion homeostasis (GO:0030007)3.23096388
74central nervous system myelination (GO:0022010)3.23078908
75axon ensheathment in central nervous system (GO:0032291)3.23078908
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22933879
77response to histamine (GO:0034776)3.21658216
78cell communication by electrical coupling (GO:0010644)3.20673031
79transmission of nerve impulse (GO:0019226)3.19373360
80startle response (GO:0001964)3.19195441
81neurotransmitter uptake (GO:0001504)3.18419625
82regulation of neurotransmitter transport (GO:0051588)3.18189253
83regulation of dendritic spine development (GO:0060998)3.17742279
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.17735068
85ATP hydrolysis coupled proton transport (GO:0015991)3.17735068
86transferrin transport (GO:0033572)3.17394219
87amino acid import (GO:0043090)3.17134085
88neuromuscular process controlling posture (GO:0050884)3.16014951
89regulation of vesicle fusion (GO:0031338)3.15677662
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.14593550
91membrane depolarization (GO:0051899)3.13142779
92axonal fasciculation (GO:0007413)3.12663940
93innervation (GO:0060384)3.11614973
94positive regulation of neurotransmitter transport (GO:0051590)3.10635506
95synapse assembly (GO:0007416)3.09497188
96fear response (GO:0042596)3.09367392
97synaptic transmission (GO:0007268)3.08903745
98negative regulation of dendrite development (GO:2000171)3.08035583
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05701563
100cellular sodium ion homeostasis (GO:0006883)3.04959932
101response to auditory stimulus (GO:0010996)3.01578916
102regulation of synaptic transmission (GO:0050804)2.99324658
103regulation of synapse maturation (GO:0090128)2.98899827
104positive regulation of synaptic transmission (GO:0050806)2.98346391
105positive regulation of neurotransmitter secretion (GO:0001956)2.97879413
106regulation of synaptic transmission, GABAergic (GO:0032228)2.97839853
107chemosensory behavior (GO:0007635)2.96441004
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95337877
109learning (GO:0007612)2.94977789
110positive regulation of synapse assembly (GO:0051965)2.94631316
111ferric iron transport (GO:0015682)2.94528678
112trivalent inorganic cation transport (GO:0072512)2.94528678
113dendritic spine morphogenesis (GO:0060997)2.94124744
114cell communication involved in cardiac conduction (GO:0086065)2.93287196
115regulation of glutamate secretion (GO:0014048)2.92897665
116membrane hyperpolarization (GO:0060081)2.92746631
117acidic amino acid transport (GO:0015800)2.92641083
118synaptic vesicle transport (GO:0048489)2.92538949
119establishment of synaptic vesicle localization (GO:0097480)2.92538949
120regulation of female receptivity (GO:0045924)2.91927254
121neuromuscular synaptic transmission (GO:0007274)2.87743280
122C4-dicarboxylate transport (GO:0015740)2.86311653
123auditory behavior (GO:0031223)2.85163879
124glycosphingolipid biosynthetic process (GO:0006688)2.83313026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52901413
2GBX2_23144817_ChIP-Seq_PC3_Human4.12553154
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22582550
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10778390
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03631911
6REST_21632747_ChIP-Seq_MESCs_Mouse2.76968262
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67412076
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63059409
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63059409
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61292427
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53075407
12TAF15_26573619_Chip-Seq_HEK293_Human2.52439210
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.50368692
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49870674
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47351246
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45822462
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.33182167
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.30927632
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25385414
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24157249
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16064874
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14117774
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.13592337
24DROSHA_22980978_ChIP-Seq_HELA_Human2.10820331
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09018900
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.07400688
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02941375
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01198452
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94996246
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94190590
31SMAD4_21799915_ChIP-Seq_A2780_Human1.87881102
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86668646
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83019919
34AR_21572438_ChIP-Seq_LNCaP_Human1.71358616
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69530541
36P300_19829295_ChIP-Seq_ESCs_Human1.65709367
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65574380
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62228994
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58004667
40ZNF274_21170338_ChIP-Seq_K562_Hela1.48916015
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45429375
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.43894188
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42145577
44* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40630507
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40505631
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.40042134
47* AR_25329375_ChIP-Seq_VCAP_Human1.39110315
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38851203
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.37057232
50IGF1R_20145208_ChIP-Seq_DFB_Human1.35384583
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.35337088
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35064319
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34414303
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33021875
55RNF2_27304074_Chip-Seq_NSC_Mouse1.31604300
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31341861
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27709275
58* PIAS1_25552417_ChIP-Seq_VCAP_Human1.26847436
59* STAT3_23295773_ChIP-Seq_U87_Human1.25799617
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25749153
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.25607320
62FUS_26573619_Chip-Seq_HEK293_Human1.20718999
63VDR_22108803_ChIP-Seq_LS180_Human1.20662274
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20444878
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18176599
66* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16583914
67AR_19668381_ChIP-Seq_PC3_Human1.14623908
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.13749660
69* TCF4_23295773_ChIP-Seq_U87_Human1.13407295
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.13376260
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11756841
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.09656397
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08901198
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08205863
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07958822
76JUN_21703547_ChIP-Seq_K562_Human1.06538959
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06518751
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05769412
79RUNX2_22187159_ChIP-Seq_PCA_Human1.05686104
80AHR_22903824_ChIP-Seq_MCF-7_Human1.05671067
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05179449
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03105870
83* ER_23166858_ChIP-Seq_MCF-7_Human1.02888043
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02153911
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00118478
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.98893179
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98533202
88FLI1_21867929_ChIP-Seq_TH2_Mouse0.96517458
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.93807277
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93180570
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.93087977
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92761592
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92209490
94P53_22387025_ChIP-Seq_ESCs_Mouse0.91884712
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91452057
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91452057
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91425267
98CBP_20019798_ChIP-Seq_JUKART_Human0.90724135
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90724135
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90558726
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.89079453
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.89074689
103SMAD4_21741376_ChIP-Seq_EPCs_Human0.88933207
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88848384
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88310995
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87383866
107KDM2B_26808549_Chip-Seq_REH_Human0.87246858
108TP53_18474530_ChIP-ChIP_U2OS_Human0.87062975
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84918079
110BCAT_22108803_ChIP-Seq_LS180_Human0.84065424
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83883736
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82380776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.65792285
2MP0003880_abnormal_central_pattern4.86264224
3MP0003635_abnormal_synaptic_transmissio3.95770945
4MP0004270_analgesia3.64184778
5MP0001968_abnormal_touch/_nociception3.59151434
6MP0009745_abnormal_behavioral_response3.41440748
7MP0002735_abnormal_chemical_nociception3.24870249
8MP0009046_muscle_twitch3.23700067
9MP0002064_seizures3.21426910
10MP0002063_abnormal_learning/memory/cond3.20737303
11MP0002736_abnormal_nociception_after3.14893718
12MP0002734_abnormal_mechanical_nocicepti2.93732252
13MP0002572_abnormal_emotion/affect_behav2.80970307
14MP0002822_catalepsy2.74847374
15MP0002272_abnormal_nervous_system2.72966308
16MP0005423_abnormal_somatic_nervous2.53178952
17MP0002733_abnormal_thermal_nociception2.41190490
18MP0001486_abnormal_startle_reflex2.33300138
19MP0001501_abnormal_sleep_pattern2.30934585
20MP0006276_abnormal_autonomic_nervous2.28750662
21MP0001970_abnormal_pain_threshold2.28535656
22MP0009780_abnormal_chondrocyte_physiolo2.25296819
23MP0001440_abnormal_grooming_behavior2.23593108
24MP0002067_abnormal_sensory_capabilities2.16457535
25MP0002184_abnormal_innervation1.96010034
26MP0003879_abnormal_hair_cell1.79784713
27MP0003329_amyloid_beta_deposits1.77082577
28MP0004858_abnormal_nervous_system1.76930343
29MP0004924_abnormal_behavior1.75854715
30MP0005386_behavior/neurological_phenoty1.75854715
31MP0008569_lethality_at_weaning1.74022330
32MP0005646_abnormal_pituitary_gland1.73834120
33MP0003787_abnormal_imprinting1.71213433
34MP0000778_abnormal_nervous_system1.70794399
35MP0004811_abnormal_neuron_physiology1.70512634
36MP0002557_abnormal_social/conspecific_i1.67635561
37MP0001529_abnormal_vocalization1.58489308
38MP0003122_maternal_imprinting1.57636557
39MP0004142_abnormal_muscle_tone1.56250694
40MP0000955_abnormal_spinal_cord1.54203264
41MP0001905_abnormal_dopamine_level1.50731418
42MP0001984_abnormal_olfaction1.48123351
43MP0002909_abnormal_adrenal_gland1.46687926
44MP0002066_abnormal_motor_capabilities/c1.41009987
45MP0002882_abnormal_neuron_morphology1.38303510
46MP0001188_hyperpigmentation1.36529497
47MP0005645_abnormal_hypothalamus_physiol1.28000019
48MP0003633_abnormal_nervous_system1.24430010
49MP0002837_dystrophic_cardiac_calcinosis1.24184144
50MP0003123_paternal_imprinting1.23066760
51MP0002876_abnormal_thyroid_physiology1.16311926
52MP0004885_abnormal_endolymph1.10632668
53MP0000751_myopathy1.10415304
54MP0003631_nervous_system_phenotype1.09721199
55MP0001986_abnormal_taste_sensitivity1.08458612
56MP0001502_abnormal_circadian_rhythm1.04334953
57MP0004147_increased_porphyrin_level1.01817224
58MP0002102_abnormal_ear_morphology0.98805290
59MP0002229_neurodegeneration0.98646515
60MP0002152_abnormal_brain_morphology0.97737265
61MP0003121_genomic_imprinting0.96773681
62MP0008872_abnormal_physiological_respon0.96675628
63MP0000013_abnormal_adipose_tissue0.93933812
64MP0001963_abnormal_hearing_physiology0.92277947
65MP0002069_abnormal_eating/drinking_beha0.89884162
66MP0004742_abnormal_vestibular_system0.89117832
67MP0004145_abnormal_muscle_electrophysio0.86391402
68MP0008874_decreased_physiological_sensi0.85861148
69MP0004085_abnormal_heartbeat0.84554538
70MP0010386_abnormal_urinary_bladder0.84349547
71MP0005551_abnormal_eye_electrophysiolog0.81022831
72MP0005535_abnormal_body_temperature0.80475154
73MP0000604_amyloidosis0.79776810
74MP0002752_abnormal_somatic_nervous0.79191841
75MP0003632_abnormal_nervous_system0.79103169
76MP0001664_abnormal_digestion0.78640302
77MP0003634_abnormal_glial_cell0.76923880
78MP0004484_altered_response_of0.73177240
79MP0005187_abnormal_penis_morphology0.72290533
80MP0004215_abnormal_myocardial_fiber0.70552793
81MP0005394_taste/olfaction_phenotype0.67158013
82MP0005499_abnormal_olfactory_system0.67158013
83MP0000631_abnormal_neuroendocrine_gland0.67070120
84MP0001177_atelectasis0.66488555
85MP0000639_abnormal_adrenal_gland0.66323536
86MP0003183_abnormal_peptide_metabolism0.65580306
87MP0004233_abnormal_muscle_weight0.65307231
88MP0005253_abnormal_eye_physiology0.64106527
89MP0008877_abnormal_DNA_methylation0.61339288
90MP0002751_abnormal_autonomic_nervous0.59762100
91MP0006072_abnormal_retinal_apoptosis0.58937481
92MP0000920_abnormal_myelination0.57776243
93MP0001943_abnormal_respiration0.57181626
94MP0002090_abnormal_vision0.55976023
95MP0005171_absent_coat_pigmentation0.55586913
96MP0003690_abnormal_glial_cell0.53140667
97MP0000026_abnormal_inner_ear0.52575805
98MP0002638_abnormal_pupillary_reflex0.51449877
99MP0001485_abnormal_pinna_reflex0.51124555
100MP0003137_abnormal_impulse_conducting0.50924698
101MP0003646_muscle_fatigue0.50087413
102MP0005623_abnormal_meninges_morphology0.49728179
103MP0010768_mortality/aging0.49083568
104MP0001299_abnormal_eye_distance/0.48846495
105MP0002082_postnatal_lethality0.48686630
106MP0010770_preweaning_lethality0.48686630
107MP0002234_abnormal_pharynx_morphology0.48488848
108MP0000569_abnormal_digit_pigmentation0.48177381
109MP0010769_abnormal_survival0.47945797
110MP0003956_abnormal_body_size0.47909290

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.47809180
2Myokymia (HP:0002411)6.57271611
3Focal seizures (HP:0007359)5.54908366
4Atonic seizures (HP:0010819)5.44034029
5Epileptic encephalopathy (HP:0200134)5.18962044
6Febrile seizures (HP:0002373)5.03001659
7Visual hallucinations (HP:0002367)4.98760066
8Progressive cerebellar ataxia (HP:0002073)4.41415745
9Absence seizures (HP:0002121)4.37150143
10Dialeptic seizures (HP:0011146)4.03491420
11Hyperventilation (HP:0002883)3.99522340
12Generalized tonic-clonic seizures (HP:0002069)3.90639941
13Action tremor (HP:0002345)3.65281900
14Supranuclear gaze palsy (HP:0000605)3.37895111
15Pheochromocytoma (HP:0002666)3.36697580
16Broad-based gait (HP:0002136)3.34759150
17Limb dystonia (HP:0002451)3.24782850
18Abnormal eating behavior (HP:0100738)3.13476065
19Impaired vibration sensation in the lower limbs (HP:0002166)3.12913434
20Intention tremor (HP:0002080)3.12572256
21Cerebral hypomyelination (HP:0006808)3.12546509
22Neuroendocrine neoplasm (HP:0100634)3.07004684
23Gaze-evoked nystagmus (HP:0000640)3.06585996
24Progressive inability to walk (HP:0002505)2.98866043
25Ankle clonus (HP:0011448)2.98491992
26Amblyopia (HP:0000646)2.97592574
27Poor eye contact (HP:0000817)2.91078591
28Depression (HP:0000716)2.90558564
29Anxiety (HP:0000739)2.90480693
30Truncal ataxia (HP:0002078)2.88318822
31Termporal pattern (HP:0011008)2.87952506
32Insidious onset (HP:0003587)2.87952506
33Dysdiadochokinesis (HP:0002075)2.86237001
34Polyphagia (HP:0002591)2.82800710
35Impaired social interactions (HP:0000735)2.70292834
36Abnormal social behavior (HP:0012433)2.70292834
37Urinary bladder sphincter dysfunction (HP:0002839)2.69609220
38Scanning speech (HP:0002168)2.68121669
39Dysmetria (HP:0001310)2.66743230
40Abnormality of the lower motor neuron (HP:0002366)2.66641916
41Failure to thrive in infancy (HP:0001531)2.66032306
42Abnormality of binocular vision (HP:0011514)2.65687746
43Diplopia (HP:0000651)2.65687746
44Epileptiform EEG discharges (HP:0011182)2.64315468
45Fetal akinesia sequence (HP:0001989)2.61868519
46Drooling (HP:0002307)2.61387579
47Excessive salivation (HP:0003781)2.61387579
48Mutism (HP:0002300)2.59082919
49Postural instability (HP:0002172)2.56321958
50Abnormality of the corticospinal tract (HP:0002492)2.54124225
51Urinary urgency (HP:0000012)2.52329850
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51559060
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.51559060
54Abnormal hair whorl (HP:0010721)2.51174213
55EEG with generalized epileptiform discharges (HP:0011198)2.47746080
56Inability to walk (HP:0002540)2.46991319
57Bradykinesia (HP:0002067)2.43637824
58Tetraplegia (HP:0002445)2.43387751
59Spastic gait (HP:0002064)2.41137894
60Hypsarrhythmia (HP:0002521)2.35848610
61Torticollis (HP:0000473)2.33860412
62Gait imbalance (HP:0002141)2.33464880
63Akinesia (HP:0002304)2.32022835
64Poor suck (HP:0002033)2.30714273
65Morphological abnormality of the pyramidal tract (HP:0002062)2.29092622
66Sleep apnea (HP:0010535)2.26918971
67Focal dystonia (HP:0004373)2.23027600
68Cerebral inclusion bodies (HP:0100314)2.22973512
69Hemiparesis (HP:0001269)2.19668674
70Clonus (HP:0002169)2.19531208
71Impaired smooth pursuit (HP:0007772)2.19410132
72Absent speech (HP:0001344)2.18273495
73Bundle branch block (HP:0011710)2.17363273
74Hypoventilation (HP:0002791)2.17140730
75Spastic tetraplegia (HP:0002510)2.14781185
76Genetic anticipation (HP:0003743)2.11640214
77Resting tremor (HP:0002322)2.10378735
78Increased circulating renin level (HP:0000848)2.10091445
79Choreoathetosis (HP:0001266)2.09008516
80Lower limb muscle weakness (HP:0007340)2.07213214
81Hyperthyroidism (HP:0000836)2.06788249
82CNS hypomyelination (HP:0003429)2.05802124
83Specific learning disability (HP:0001328)2.05799802
84Impaired vibratory sensation (HP:0002495)2.05704210
85Delusions (HP:0000746)2.05427089
86Blue irides (HP:0000635)2.03805345
87Status epilepticus (HP:0002133)2.03798914
88Craniofacial dystonia (HP:0012179)2.03361457
89Neoplasm of the peripheral nervous system (HP:0100007)2.02825921
90Peripheral hypomyelination (HP:0007182)2.02361077
91Abnormality of pain sensation (HP:0010832)2.02087349
92Impaired pain sensation (HP:0007328)2.02087349
93Muscular hypotonia of the trunk (HP:0008936)2.01891340
94Rigidity (HP:0002063)1.99366954
95Amyotrophic lateral sclerosis (HP:0007354)1.97954736
96Neurofibrillary tangles (HP:0002185)1.97454252
97Gait ataxia (HP:0002066)1.96826362
98Abnormality of ocular smooth pursuit (HP:0000617)1.96133219
99Psychosis (HP:0000709)1.95310302
100Dysmetric saccades (HP:0000641)1.94983426
101Abnormal EKG (HP:0003115)1.94867219
102Agitation (HP:0000713)1.94425244
103Diminished movement (HP:0002374)1.94171474
104Papilledema (HP:0001085)1.94102017
105Syncope (HP:0001279)1.93634135
106Prolonged QT interval (HP:0001657)1.93169995
107Oligomenorrhea (HP:0000876)1.91977531
108Generalized myoclonic seizures (HP:0002123)1.91275095
109Incomplete penetrance (HP:0003829)1.91050316
110Acute necrotizing encephalopathy (HP:0006965)1.90866772
111Congenital primary aphakia (HP:0007707)1.89635649
112Ventricular fibrillation (HP:0001663)1.89566354
113Esotropia (HP:0000565)1.88125896
114Ulnar claw (HP:0001178)1.87832900
115Protruding tongue (HP:0010808)1.86052513
116Medial flaring of the eyebrow (HP:0010747)1.85370912
117Abnormal mitochondria in muscle tissue (HP:0008316)1.85079168
118Stereotypic behavior (HP:0000733)1.84977454
119Hemiplegia (HP:0002301)1.82815555
120Neuronal loss in central nervous system (HP:0002529)1.82117620
121Generalized hypotonia (HP:0001290)1.81218446
122Spastic tetraparesis (HP:0001285)1.78085438
123Abnormality of saccadic eye movements (HP:0000570)1.72639539
124Annular pancreas (HP:0001734)1.70039942
125Split foot (HP:0001839)1.69205651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.34235835
2CASK4.01921441
3MAP3K123.40767321
4MAP3K93.31893697
5MAP3K43.31194128
6MAP2K73.05200756
7MARK13.02466027
8EPHA42.97464399
9MINK12.81059362
10MAP2K42.21064092
11DAPK22.19682086
12PLK22.07575646
13GRK51.97981560
14CDK191.84130732
15NTRK21.81329784
16DAPK11.72336644
17RIPK41.67325882
18PAK61.67286841
19NTRK11.66915643
20KSR21.61249595
21FRK1.54526506
22PRPF4B1.50493485
23MAPK131.48675408
24CDK51.39381499
25ARAF1.39256324
26PRKCG1.37934242
27CAMKK11.27324552
28PNCK1.21793803
29KSR11.21376491
30AKT31.13773516
31MAP4K21.10673387
32OXSR11.09559578
33CAMK2A1.08512304
34PHKG11.08019192
35PHKG21.08019192
36SGK2231.07959980
37SGK4941.07959980
38CAMKK21.06499889
39TNIK1.06134467
40LATS21.03244410
41SIK31.01316186
42PRKD31.00970261
43CCNB10.99824201
44TSSK60.99294700
45TRIM280.98724476
46SGK20.95494624
47UHMK10.94170701
48SIK20.93538803
49CDK180.92159688
50PTK2B0.91037580
51CDK140.90582767
52NME10.88621957
53CAMK2B0.88452822
54CSNK1G30.88131066
55MAP3K20.87827690
56PKN10.86823780
57CDK150.86770045
58MAPK120.86524216
59STK380.84983950
60LMTK20.84947000
61FES0.84374386
62FGFR20.82213388
63RET0.75803070
64CSNK1G20.75789706
65CDK11A0.74356930
66PDK30.74290193
67PDK40.74290193
68PRKCE0.72556971
69BMPR20.67717226
70SGK30.67693467
71CSNK1G10.67642116
72CAMK10.66430136
73LIMK10.65946968
74PINK10.65647640
75PRKCH0.63051569
76CAMK40.62813234
77CSNK1A1L0.61360634
78ERBB30.60901290
79DYRK1A0.60305422
80STK110.58886624
81CAMK2G0.58376853
82SGK10.56400556
83ADRBK20.55714102
84BRAF0.55016307
85TNK20.54834165
86PAK30.54633985
87FER0.54211106
88TYRO30.53480968
89CAMK2D0.52913905
90DYRK20.52122546
91GRK70.51235772
92NEK60.50995246
93ADRBK10.50636941
94MAP2K10.50438343
95BCR0.50414265
96STK390.49477897
97MAP3K10.49207629
98PDK10.47826663
99MAP3K130.46996215
100MAPKAPK50.46935755
101FGR0.46513153
102RAF10.45845752
103WNK10.45646900
104PDPK10.44205202
105MAPKAPK30.44029202
106MAPK100.43647740
107ALK0.43247358
108ROCK20.41285993
109PRKG10.41209265
110MAP2K60.41178282
111RPS6KA20.40515826
112WNK30.40024179
113SCYL20.39584910
114PRKCZ0.39438024
115PRKACA0.39366197
116TAOK10.38961345
117MARK20.38835260
118DAPK30.38545480
119PRKCA0.36902860
120FYN0.36600932
121* RPS6KA30.36389723
122CSNK1D0.34517139
123PRKAA10.34313545
124CSNK1A10.30663851
125BRSK10.29957504

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.01855565
2Nicotine addiction_Homo sapiens_hsa050333.96928792
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76890428
4Collecting duct acid secretion_Homo sapiens_hsa049662.72785510
5GABAergic synapse_Homo sapiens_hsa047272.68230024
6Olfactory transduction_Homo sapiens_hsa047402.62387634
7Circadian entrainment_Homo sapiens_hsa047132.57832901
8Long-term potentiation_Homo sapiens_hsa047202.52764354
9Morphine addiction_Homo sapiens_hsa050322.45294989
10Glutamatergic synapse_Homo sapiens_hsa047242.40846681
11Amphetamine addiction_Homo sapiens_hsa050312.34090057
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19763243
13Dopaminergic synapse_Homo sapiens_hsa047282.19762540
14Salivary secretion_Homo sapiens_hsa049702.05855508
15Taste transduction_Homo sapiens_hsa047421.97872132
16Insulin secretion_Homo sapiens_hsa049111.88106340
17Long-term depression_Homo sapiens_hsa047301.80566401
18Cholinergic synapse_Homo sapiens_hsa047251.76314104
19Serotonergic synapse_Homo sapiens_hsa047261.75948183
20Gastric acid secretion_Homo sapiens_hsa049711.69895923
21Vibrio cholerae infection_Homo sapiens_hsa051101.68598990
22Renin secretion_Homo sapiens_hsa049241.61287004
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57698987
24* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56952884
25Calcium signaling pathway_Homo sapiens_hsa040201.55542061
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51262150
27Cocaine addiction_Homo sapiens_hsa050301.45157633
28Oxytocin signaling pathway_Homo sapiens_hsa049211.43592347
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36242098
30Oxidative phosphorylation_Homo sapiens_hsa001901.34503495
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30410194
32Gap junction_Homo sapiens_hsa045401.27919654
33GnRH signaling pathway_Homo sapiens_hsa049121.25324730
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23922936
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23038147
36Cardiac muscle contraction_Homo sapiens_hsa042601.17051506
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16816901
38Vitamin B6 metabolism_Homo sapiens_hsa007501.13517353
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09909146
40cAMP signaling pathway_Homo sapiens_hsa040241.07037413
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05695355
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04326608
43Alzheimers disease_Homo sapiens_hsa050101.01224479
44Estrogen signaling pathway_Homo sapiens_hsa049151.00359365
45Axon guidance_Homo sapiens_hsa043600.98043681
46Glioma_Homo sapiens_hsa052140.94076431
47Type II diabetes mellitus_Homo sapiens_hsa049300.93073627
48Parkinsons disease_Homo sapiens_hsa050120.92244284
49ErbB signaling pathway_Homo sapiens_hsa040120.91290274
50Phototransduction_Homo sapiens_hsa047440.90769702
51Melanogenesis_Homo sapiens_hsa049160.89873255
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87120437
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.84273006
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83133583
55Oocyte meiosis_Homo sapiens_hsa041140.79516626
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73973002
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73781059
58Rheumatoid arthritis_Homo sapiens_hsa053230.70744834
59Pancreatic secretion_Homo sapiens_hsa049720.68342196
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66349334
61Thyroid hormone synthesis_Homo sapiens_hsa049180.65010109
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64272757
63Dorso-ventral axis formation_Homo sapiens_hsa043200.62794633
64MAPK signaling pathway_Homo sapiens_hsa040100.58981137
65Huntingtons disease_Homo sapiens_hsa050160.58625853
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.57162171
67Dilated cardiomyopathy_Homo sapiens_hsa054140.57118870
68Type I diabetes mellitus_Homo sapiens_hsa049400.55331704
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54359450
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.54225209
71Glucagon signaling pathway_Homo sapiens_hsa049220.52549123
72Choline metabolism in cancer_Homo sapiens_hsa052310.50542172
73Ras signaling pathway_Homo sapiens_hsa040140.50537115
74* Phagosome_Homo sapiens_hsa041450.49519190
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.48660201
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48331565
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47603199
78Nitrogen metabolism_Homo sapiens_hsa009100.46472805
79Alcoholism_Homo sapiens_hsa050340.45890517
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45867537
81Regulation of autophagy_Homo sapiens_hsa041400.45227477
82Folate biosynthesis_Homo sapiens_hsa007900.43449861
83Inositol phosphate metabolism_Homo sapiens_hsa005620.43154299
84Arginine and proline metabolism_Homo sapiens_hsa003300.42611855
85Rap1 signaling pathway_Homo sapiens_hsa040150.41053342
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38698450
87Endocytosis_Homo sapiens_hsa041440.38150654
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.37841742
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37226889
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36778174
91Mineral absorption_Homo sapiens_hsa049780.35385987
92Insulin signaling pathway_Homo sapiens_hsa049100.35158562
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34785828
94beta-Alanine metabolism_Homo sapiens_hsa004100.34148970
95VEGF signaling pathway_Homo sapiens_hsa043700.32727380
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32302312
97Ether lipid metabolism_Homo sapiens_hsa005650.30864815
98Circadian rhythm_Homo sapiens_hsa047100.30126772
99Endometrial cancer_Homo sapiens_hsa052130.29322966
100Bile secretion_Homo sapiens_hsa049760.29290846
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29246490
102Histidine metabolism_Homo sapiens_hsa003400.28827329
103Prion diseases_Homo sapiens_hsa050200.28755308
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28747279
105Ovarian steroidogenesis_Homo sapiens_hsa049130.27626443
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27548512
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27478743
108Fatty acid biosynthesis_Homo sapiens_hsa000610.27343495
109Melanoma_Homo sapiens_hsa052180.26067782
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25703408
111Wnt signaling pathway_Homo sapiens_hsa043100.25293714
112mTOR signaling pathway_Homo sapiens_hsa041500.25167291
113Butanoate metabolism_Homo sapiens_hsa006500.25154219
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24825855
115Arginine biosynthesis_Homo sapiens_hsa002200.21289130
116AMPK signaling pathway_Homo sapiens_hsa041520.21207620
117Tight junction_Homo sapiens_hsa045300.21077623
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20731167

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