DYNC1I2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.54410285
2axon ensheathment in central nervous system (GO:0032291)6.54410285
3pyrimidine nucleobase catabolic process (GO:0006208)6.31677436
4nucleobase catabolic process (GO:0046113)4.97551367
5neuron cell-cell adhesion (GO:0007158)4.35910284
6cell migration in hindbrain (GO:0021535)4.13973281
7sequestering of actin monomers (GO:0042989)3.92624267
8presynaptic membrane organization (GO:0097090)3.85403817
9neuron recognition (GO:0008038)3.78896824
10substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.76162299
11substrate-independent telencephalic tangential migration (GO:0021826)3.76162299
12presynaptic membrane assembly (GO:0097105)3.75808922
13long-chain fatty acid biosynthetic process (GO:0042759)3.73399654
14axon ensheathment (GO:0008366)3.64449083
15ensheathment of neurons (GO:0007272)3.64449083
16myelination (GO:0042552)3.64382887
17axonal fasciculation (GO:0007413)3.62206677
18ganglion development (GO:0061548)3.51122731
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37987723
20axon extension (GO:0048675)3.35879938
21negative regulation of neurotransmitter transport (GO:0051589)3.35156772
22dendritic spine morphogenesis (GO:0060997)3.28177025
23protein localization to synapse (GO:0035418)3.25694103
24cerebral cortex radially oriented cell migration (GO:0021799)3.24106807
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20140191
26auditory behavior (GO:0031223)3.20065794
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.17624140
28vocalization behavior (GO:0071625)3.17408497
29central nervous system projection neuron axonogenesis (GO:0021952)3.17052280
30dendrite morphogenesis (GO:0048813)3.17047010
31establishment of mitochondrion localization (GO:0051654)3.15975827
32transmission of nerve impulse (GO:0019226)3.14919724
33synaptic vesicle exocytosis (GO:0016079)3.12776900
34neuronal action potential propagation (GO:0019227)3.12349814
35neuron remodeling (GO:0016322)3.11895126
36fatty acid elongation (GO:0030497)3.10478958
37axon extension involved in axon guidance (GO:0048846)3.07672669
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.07672669
39protein neddylation (GO:0045116)3.07190164
40limb bud formation (GO:0060174)3.05197291
41regulation of collateral sprouting (GO:0048670)3.04216367
42synaptic vesicle maturation (GO:0016188)2.96370007
43layer formation in cerebral cortex (GO:0021819)2.96245535
44glutamate receptor signaling pathway (GO:0007215)2.96053841
45detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.93308589
46detection of temperature stimulus involved in sensory perception (GO:0050961)2.93308589
47positive regulation of dendritic spine morphogenesis (GO:0061003)2.92286979
48photoreceptor cell differentiation (GO:0046530)2.92127209
49eye photoreceptor cell differentiation (GO:0001754)2.92127209
50regulation of glutamate secretion (GO:0014048)2.90641032
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.89594010
52calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.89523158
53nonmotile primary cilium assembly (GO:0035058)2.89213578
54neurofilament cytoskeleton organization (GO:0060052)2.88862128
55negative regulation of oligodendrocyte differentiation (GO:0048715)2.88581847
56mating behavior (GO:0007617)2.87235217
57behavioral response to nicotine (GO:0035095)2.86873943
58calcium-mediated signaling using intracellular calcium source (GO:0035584)2.85396249
59negative regulation of axon guidance (GO:1902668)2.85084809
60regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84553784
61mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.84013823
62positive regulation of amino acid transport (GO:0051957)2.82940715
63negative regulation of axonogenesis (GO:0050771)2.82584651
64negative regulation of neurotransmitter secretion (GO:0046929)2.81902850
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80744746
66membrane assembly (GO:0071709)2.80092176
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78189061
68olfactory bulb development (GO:0021772)2.77408654
69neuron projection extension (GO:1990138)2.76549019
70negative regulation of protein localization to cell surface (GO:2000009)2.75431738
71negative regulation of axon extension (GO:0030517)2.75321381
72neuronal action potential (GO:0019228)2.75296265
73adult walking behavior (GO:0007628)2.74895702
74neurotransmitter-gated ion channel clustering (GO:0072578)2.74375692
75substantia nigra development (GO:0021762)2.74119395
76hippocampus development (GO:0021766)2.72544600
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71861604
78gamma-aminobutyric acid signaling pathway (GO:0007214)2.71653317
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71525903
80positive regulation of synapse assembly (GO:0051965)2.71459764
81spinal cord development (GO:0021510)2.70336011
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70328069
83chaperone-mediated protein transport (GO:0072321)2.69146596
84regulation of synaptic vesicle exocytosis (GO:2000300)2.68994551
85negative regulation of microtubule polymerization (GO:0031115)2.67971042
86gamma-aminobutyric acid transport (GO:0015812)2.66614974
87short-term memory (GO:0007614)2.66599319
88glutamate secretion (GO:0014047)2.66172898
89cerebral cortex cell migration (GO:0021795)2.64304220
90positive regulation of actin filament depolymerization (GO:0030836)2.63510593
91response to auditory stimulus (GO:0010996)2.63506494
92regulation of axon guidance (GO:1902667)2.62270561
93peptidyl-tyrosine autophosphorylation (GO:0038083)2.61905754
94mechanosensory behavior (GO:0007638)2.61183203
95positive regulation of mitochondrial fission (GO:0090141)2.61071648
96neuron migration (GO:0001764)2.60726027
97aggressive behavior (GO:0002118)2.58099438
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57868251
99neuronal ion channel clustering (GO:0045161)2.57537476
100synaptic transmission, glutamatergic (GO:0035249)2.57257042
101positive regulation of gastrulation (GO:2000543)2.56582004
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56142151
103retinal ganglion cell axon guidance (GO:0031290)2.55984988
104positive regulation of protein depolymerization (GO:1901881)2.55844434
105organelle transport along microtubule (GO:0072384)2.55295184
106postsynaptic membrane organization (GO:0001941)2.55244857
107vesicle transport along microtubule (GO:0047496)2.55215918
108regulation of glutamate receptor signaling pathway (GO:1900449)2.55206387
109neuron-neuron synaptic transmission (GO:0007270)2.54151173
110central nervous system neuron axonogenesis (GO:0021955)2.53660771
111detection of temperature stimulus (GO:0016048)2.53564760
112apical protein localization (GO:0045176)2.52255880
113mitochondrion transport along microtubule (GO:0047497)2.51003136
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51003136
115regulation of vesicle fusion (GO:0031338)2.50380665
116synapse assembly (GO:0007416)2.47283836
117dendrite development (GO:0016358)2.46535481
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.45902664
119peripheral nervous system axon ensheathment (GO:0032292)2.44699658
120myelination in peripheral nervous system (GO:0022011)2.44699658
121regulation of synapse structural plasticity (GO:0051823)2.42988461
122intraciliary transport (GO:0042073)2.42956781
123cytoskeleton-dependent intracellular transport (GO:0030705)2.41919895
124somite development (GO:0061053)2.41818870
125astrocyte development (GO:0014002)2.40796449
126membrane depolarization during action potential (GO:0086010)2.40442092
127maternal behavior (GO:0042711)2.40322966
128dopamine biosynthetic process (GO:0042416)2.39168096
129sympathetic nervous system development (GO:0048485)2.38709903
130cornea development in camera-type eye (GO:0061303)2.38334202
131regulation of respiratory system process (GO:0044065)2.37945993
132axon development (GO:0061564)2.37339218
133regulation of development, heterochronic (GO:0040034)2.36846769
134axonogenesis (GO:0007409)2.36758484
135regulation of synaptic transmission, GABAergic (GO:0032228)2.36564664
136synapse organization (GO:0050808)2.35654728
137regulation of synapse assembly (GO:0051963)2.35585103
138actin filament depolymerization (GO:0030042)2.35331574
139glycine transport (GO:0015816)2.35117336
140glycerophospholipid catabolic process (GO:0046475)2.34883419
141forebrain neuron differentiation (GO:0021879)2.34763292
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34491045
143regulation of dendritic spine morphogenesis (GO:0061001)2.34415579
144enteric nervous system development (GO:0048484)2.34271280
145regulation of neuronal synaptic plasticity (GO:0048168)2.34019122
146hindbrain development (GO:0030902)2.33626280
147dopaminergic neuron differentiation (GO:0071542)2.32993903
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32966495
149spinal cord association neuron differentiation (GO:0021527)2.30030471
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29470355
151protein localization to cilium (GO:0061512)2.29260092
152negative regulation of glial cell differentiation (GO:0045686)2.28333503
153limb development (GO:0060173)2.26748172
154appendage development (GO:0048736)2.26748172
155negative chemotaxis (GO:0050919)2.25259298
156innervation (GO:0060384)2.25251823
157regulation of timing of cell differentiation (GO:0048505)2.24549295
158neuron fate determination (GO:0048664)2.24347870
159startle response (GO:0001964)2.22405482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10834977
2GBX2_23144817_ChIP-Seq_PC3_Human3.61871311
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86959710
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85725735
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85499927
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76771105
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.67871755
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55815055
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.55127208
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54748198
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54200004
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54200004
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45642883
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42240185
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25152905
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21641393
17TAF15_26573619_Chip-Seq_HEK293_Human2.13641219
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12770333
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11788083
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.11573315
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07869069
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.06931859
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06792388
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.05493747
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.01958937
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92302544
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85859945
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85345850
29AR_21572438_ChIP-Seq_LNCaP_Human1.84839465
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79614452
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79114595
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78873269
33P300_19829295_ChIP-Seq_ESCs_Human1.75866570
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75239829
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73986029
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73528650
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72887492
38REST_21632747_ChIP-Seq_MESCs_Mouse1.72571798
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68779565
40EWS_26573619_Chip-Seq_HEK293_Human1.67414932
41VDR_22108803_ChIP-Seq_LS180_Human1.66755367
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63828992
43IGF1R_20145208_ChIP-Seq_DFB_Human1.62109355
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57798107
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56487630
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.54067052
47SMAD4_21799915_ChIP-Seq_A2780_Human1.53992858
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.51195272
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49039681
50RNF2_27304074_Chip-Seq_NSC_Mouse1.48480866
51ER_23166858_ChIP-Seq_MCF-7_Human1.48394727
52DROSHA_22980978_ChIP-Seq_HELA_Human1.45254229
53FUS_26573619_Chip-Seq_HEK293_Human1.44036957
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.43692590
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41457904
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39600748
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34760834
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.32373840
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30078366
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28479770
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28271235
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25833430
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24942163
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.23217660
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22978391
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21576309
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20629096
68* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19254025
69STAT3_23295773_ChIP-Seq_U87_Human1.18987357
70* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18052055
71* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17973500
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.17421524
73TP53_18474530_ChIP-ChIP_U2OS_Human1.16166023
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16057964
75SOX9_26525672_Chip-Seq_HEART_Mouse1.14962352
76AR_25329375_ChIP-Seq_VCAP_Human1.14701297
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11834629
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.11742440
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.11537594
80ZNF274_21170338_ChIP-Seq_K562_Hela1.10861674
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10239005
82AHR_22903824_ChIP-Seq_MCF-7_Human1.10060360
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.09635298
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.09282065
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08586520
86* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08543801
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.07942240
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.07821298
89CBP_20019798_ChIP-Seq_JUKART_Human1.07445382
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07445382
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07166775
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.06725174
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06436893
94* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06248112
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06162379
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05862959
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.05780651
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.05603636
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.04730427
100* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04637493
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.04175561
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.03479848
103JUN_21703547_ChIP-Seq_K562_Human1.01755898
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00530191
105* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00279896
106TCF4_23295773_ChIP-Seq_U87_Human0.99966468
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99956941
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99514628
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99514628
110TAL1_26923725_Chip-Seq_HPCs_Mouse0.99513920
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.98763618
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98494292
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97135467
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96996214
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96955864
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96930298
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96396673
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95713203
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94818334
120* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93882639
121KDM2B_26808549_Chip-Seq_REH_Human0.93444679
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92515303
123* P53_22387025_ChIP-Seq_ESCs_Mouse0.92416612
124* P300_18555785_Chip-Seq_ESCs_Mouse0.90443022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.19987475
2MP0004270_analgesia3.66706662
3MP0004859_abnormal_synaptic_plasticity3.37188557
4MP0002735_abnormal_chemical_nociception3.36156223
5MP0001968_abnormal_touch/_nociception3.13137233
6MP0002734_abnormal_mechanical_nocicepti3.08066774
7MP0002736_abnormal_nociception_after2.95702124
8MP0005423_abnormal_somatic_nervous2.93595493
9MP0003635_abnormal_synaptic_transmissio2.69906900
10MP0000778_abnormal_nervous_system2.65364208
11MP0000920_abnormal_myelination2.52023203
12MP0006276_abnormal_autonomic_nervous2.45662444
13MP0002064_seizures2.41905979
14MP0002733_abnormal_thermal_nociception2.41049295
15MP0005171_absent_coat_pigmentation2.32011186
16MP0001970_abnormal_pain_threshold2.31764706
17MP0002272_abnormal_nervous_system2.31643510
18MP0009745_abnormal_behavioral_response2.26686488
19MP0001486_abnormal_startle_reflex2.15534529
20MP0002063_abnormal_learning/memory/cond2.11535644
21MP0008789_abnormal_olfactory_epithelium2.10835681
22MP0005499_abnormal_olfactory_system2.07896791
23MP0005394_taste/olfaction_phenotype2.07896791
24MP0001986_abnormal_taste_sensitivity2.06958175
25MP0001905_abnormal_dopamine_level2.05128335
26MP0002572_abnormal_emotion/affect_behav2.02605719
27MP0009046_muscle_twitch1.99573684
28MP0002184_abnormal_innervation1.92171947
29MP0001529_abnormal_vocalization1.91643726
30MP0005645_abnormal_hypothalamus_physiol1.86340218
31MP0001440_abnormal_grooming_behavior1.83150808
32MP0004742_abnormal_vestibular_system1.82248370
33MP0002067_abnormal_sensory_capabilities1.81849026
34MP0003890_abnormal_embryonic-extraembry1.77949858
35MP0003121_genomic_imprinting1.74884458
36MP0001188_hyperpigmentation1.74106710
37MP0005409_darkened_coat_color1.70791812
38MP0001346_abnormal_lacrimal_gland1.68076246
39MP0000049_abnormal_middle_ear1.62236338
40MP0004133_heterotaxia1.59352718
41MP0009379_abnormal_foot_pigmentation1.56458489
42MP0000955_abnormal_spinal_cord1.52552265
43MP0003329_amyloid_beta_deposits1.52420656
44MP0002882_abnormal_neuron_morphology1.51542288
45MP0002234_abnormal_pharynx_morphology1.50163060
46MP0004858_abnormal_nervous_system1.48052706
47MP0003634_abnormal_glial_cell1.47829936
48MP0004811_abnormal_neuron_physiology1.46148465
49MP0003122_maternal_imprinting1.43596578
50MP0003937_abnormal_limbs/digits/tail_de1.36264249
51MP0002557_abnormal_social/conspecific_i1.36131553
52MP0003950_abnormal_plasma_membrane1.35910607
53MP0003690_abnormal_glial_cell1.35641158
54MP0004142_abnormal_muscle_tone1.35633954
55MP0003136_yellow_coat_color1.32312732
56MP0006292_abnormal_olfactory_placode1.31228175
57MP0002233_abnormal_nose_morphology1.31137020
58MP0010030_abnormal_orbit_morphology1.30593452
59MP0010386_abnormal_urinary_bladder1.30228676
60MP0001299_abnormal_eye_distance/1.29983630
61MP0004924_abnormal_behavior1.28221069
62MP0005386_behavior/neurological_phenoty1.28221069
63MP0002638_abnormal_pupillary_reflex1.27520977
64MP0005623_abnormal_meninges_morphology1.26254555
65MP0003755_abnormal_palate_morphology1.25973429
66MP0004885_abnormal_endolymph1.25265378
67MP0002066_abnormal_motor_capabilities/c1.24982745
68MP0002752_abnormal_somatic_nervous1.18562356
69MP0001501_abnormal_sleep_pattern1.18509322
70MP0003787_abnormal_imprinting1.18487374
71MP0005187_abnormal_penis_morphology1.13259937
72MP0002229_neurodegeneration1.13158654
73MP0001485_abnormal_pinna_reflex1.12496454
74MP0003119_abnormal_digestive_system1.11324286
75MP0008569_lethality_at_weaning1.09985007
76MP0004145_abnormal_muscle_electrophysio1.09369983
77MP0003631_nervous_system_phenotype1.09022879
78MP0003633_abnormal_nervous_system1.07467718
79MP0003632_abnormal_nervous_system1.05358998
80MP0000647_abnormal_sebaceous_gland1.04424107
81MP0002152_abnormal_brain_morphology1.04286113
82MP0001293_anophthalmia1.04092437
83MP0002751_abnormal_autonomic_nervous1.03993722
84MP0001984_abnormal_olfaction1.00200765
85MP0001502_abnormal_circadian_rhythm0.99672120
86MP0003011_delayed_dark_adaptation0.98923771
87MP0000569_abnormal_digit_pigmentation0.98857123
88MP0000534_abnormal_ureter_morphology0.98675375
89MP0000579_abnormal_nail_morphology0.98313876
90MP0008877_abnormal_DNA_methylation0.98284005
91MP0001286_abnormal_eye_development0.97593499
92MP0000631_abnormal_neuroendocrine_gland0.97336010
93MP0002653_abnormal_ependyma_morphology0.97124540
94MP0003942_abnormal_urinary_system0.97068181
95MP0005551_abnormal_eye_electrophysiolog0.96636570
96MP0003935_abnormal_craniofacial_develop0.95943351
97MP0002697_abnormal_eye_size0.94873988
98MP0001963_abnormal_hearing_physiology0.94202267
99MP0002822_catalepsy0.93740235
100MP0005410_abnormal_fertilization0.93393036
101MP0002938_white_spotting0.93187107
102MP0002909_abnormal_adrenal_gland0.91020466
103MP0006072_abnormal_retinal_apoptosis0.88285555
104MP0005248_abnormal_Harderian_gland0.85671534
105MP0002081_perinatal_lethality0.85548271
106MP0005503_abnormal_tendon_morphology0.85091909
107MP0002282_abnormal_trachea_morphology0.83674628
108MP0001879_abnormal_lymphatic_vessel0.81523344
109MP0005391_vision/eye_phenotype0.81223701
110MP0000537_abnormal_urethra_morphology0.81076930
111MP0002102_abnormal_ear_morphology0.80502083
112MP0009780_abnormal_chondrocyte_physiolo0.80082665
113MP0005646_abnormal_pituitary_gland0.78858775
114MP0003567_abnormal_fetal_cardiomyocyte0.78806609
115MP0000462_abnormal_digestive_system0.76149294
116MP0005379_endocrine/exocrine_gland_phen0.75017069
117MP0009250_abnormal_appendicular_skeleto0.74443624
118MP0000026_abnormal_inner_ear0.73937909
119MP0003938_abnormal_ear_development0.73341789
120MP0005195_abnormal_posterior_eye0.73217532
121MP0003861_abnormal_nervous_system0.73137093
122MP0003183_abnormal_peptide_metabolism0.72605090
123MP0000604_amyloidosis0.71724489
124MP0000751_myopathy0.69385732
125MP0003385_abnormal_body_wall0.67755162
126MP0004134_abnormal_chest_morphology0.67642082
127MP0001348_abnormal_lacrimal_gland0.67392846
128MP0001943_abnormal_respiration0.66933358
129MP0005253_abnormal_eye_physiology0.64029515
130MP0000538_abnormal_urinary_bladder0.63474265
131MP0010678_abnormal_skin_adnexa0.62591752
132MP0000566_synostosis0.61230769
133MP0004272_abnormal_basement_membrane0.60822159
134MP0001177_atelectasis0.58971733
135MP0003879_abnormal_hair_cell0.57792394
136MP0002295_abnormal_pulmonary_circulatio0.55587786

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.01432618
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.01432618
3Abnormality of the corticospinal tract (HP:0002492)4.49357655
4Myokymia (HP:0002411)4.48526748
5Neurofibrillary tangles (HP:0002185)4.28983871
6Focal motor seizures (HP:0011153)4.21011656
7Atonic seizures (HP:0010819)3.68935919
8Cortical dysplasia (HP:0002539)3.60728306
9Focal seizures (HP:0007359)3.58986020
10Supranuclear gaze palsy (HP:0000605)3.57894681
11Peripheral hypomyelination (HP:0007182)3.53472170
12Insidious onset (HP:0003587)3.53104975
13Termporal pattern (HP:0011008)3.53104975
14Alacrima (HP:0000522)3.38595643
15Parakeratosis (HP:0001036)3.31942153
16Cerebral inclusion bodies (HP:0100314)3.31840165
17Ankle clonus (HP:0011448)3.16959400
18Spastic gait (HP:0002064)2.98593008
19Limb dystonia (HP:0002451)2.95120834
20Sensory axonal neuropathy (HP:0003390)2.95029643
21Abnormality of the labia minora (HP:0012880)2.92069805
22Epileptic encephalopathy (HP:0200134)2.86079026
23Action tremor (HP:0002345)2.73327238
24Retinal dysplasia (HP:0007973)2.73258542
25Lissencephaly (HP:0001339)2.68772442
26Ulnar claw (HP:0001178)2.62922853
27Congenital primary aphakia (HP:0007707)2.60515754
28Hypothermia (HP:0002045)2.60179430
29Pachygyria (HP:0001302)2.59528043
30Febrile seizures (HP:0002373)2.59308141
31Decreased lacrimation (HP:0000633)2.58667246
32Lower limb muscle weakness (HP:0007340)2.57438901
33Progressive cerebellar ataxia (HP:0002073)2.55549150
34Nephrogenic diabetes insipidus (HP:0009806)2.52394233
35Dialeptic seizures (HP:0011146)2.48598751
36Urinary bladder sphincter dysfunction (HP:0002839)2.48490826
37Broad-based gait (HP:0002136)2.46653356
38Polyphagia (HP:0002591)2.43036894
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.38095013
40Onion bulb formation (HP:0003383)2.37570717
41Hepatoblastoma (HP:0002884)2.35029114
42Akinesia (HP:0002304)2.31427391
43Urinary urgency (HP:0000012)2.30946224
44Abnormal hair whorl (HP:0010721)2.27441868
45Absence seizures (HP:0002121)2.25564487
46Thickened helices (HP:0000391)2.24830459
47Dysmetria (HP:0001310)2.23704849
48Megalencephaly (HP:0001355)2.23407712
49Split foot (HP:0001839)2.22633625
50Amblyopia (HP:0000646)2.21865228
51Buphthalmos (HP:0000557)2.20480033
52Generalized tonic-clonic seizures (HP:0002069)2.20185307
53Hemiparesis (HP:0001269)2.19855854
54Foot dorsiflexor weakness (HP:0009027)2.18603211
55Excessive salivation (HP:0003781)2.18041097
56Drooling (HP:0002307)2.18041097
57Progressive inability to walk (HP:0002505)2.15898169
58Oligodactyly (hands) (HP:0001180)2.15006669
59Septo-optic dysplasia (HP:0100842)2.14798275
60Molar tooth sign on MRI (HP:0002419)2.13968259
61Abnormality of midbrain morphology (HP:0002418)2.13968259
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.13254494
63Absent/shortened dynein arms (HP:0200106)2.13254494
64Nephronophthisis (HP:0000090)2.12271481
65Impaired vibration sensation in the lower limbs (HP:0002166)2.11052718
66Genital tract atresia (HP:0001827)2.09179380
67Abnormal eating behavior (HP:0100738)2.09116023
68Vaginal atresia (HP:0000148)2.03939393
69Dysautonomia (HP:0002459)2.02244535
70Abnormality of the foot musculature (HP:0001436)1.98642718
71Stenosis of the external auditory canal (HP:0000402)1.98611859
72Abnormality of salivation (HP:0100755)1.98293170
73Chin dimple (HP:0010751)1.97883505
74Wrist flexion contracture (HP:0001239)1.96550307
75Abnormal ciliary motility (HP:0012262)1.95764341
76Abnormal autonomic nervous system physiology (HP:0012332)1.94743355
77Hammertoe (HP:0001765)1.94186932
78Amyotrophic lateral sclerosis (HP:0007354)1.93874000
79Optic nerve hypoplasia (HP:0000609)1.93695332
80Intellectual disability, moderate (HP:0002342)1.93248969
81Absent speech (HP:0001344)1.92897193
82Steppage gait (HP:0003376)1.92834554
83Anterior segment dysgenesis (HP:0007700)1.92466320
84Morphological abnormality of the pyramidal tract (HP:0002062)1.89646716
85Esotropia (HP:0000565)1.89383699
86Pheochromocytoma (HP:0002666)1.89162888
87Scanning speech (HP:0002168)1.87898667
88Cupped ear (HP:0000378)1.86784757
89Mutism (HP:0002300)1.86686396
90Abnormality of binocular vision (HP:0011514)1.86650244
91Diplopia (HP:0000651)1.86650244
92Gait imbalance (HP:0002141)1.86428506
93Spastic tetraplegia (HP:0002510)1.85994055
94Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84274684
95Postaxial hand polydactyly (HP:0001162)1.83566160
96Acute necrotizing encephalopathy (HP:0006965)1.83454396
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82831522
98Hypoplasia of the brainstem (HP:0002365)1.82831522
99Exotropia (HP:0000577)1.82541546
100Type II lissencephaly (HP:0007260)1.82517625
101Decreased motor nerve conduction velocity (HP:0003431)1.81653898
102Labial hypoplasia (HP:0000066)1.81174311
103Volvulus (HP:0002580)1.79835121
104Poor suck (HP:0002033)1.79828005
105Specific learning disability (HP:0001328)1.79337249
106Hypsarrhythmia (HP:0002521)1.79311421
107Segmental peripheral demyelination/remyelination (HP:0003481)1.78466394
108Hyperventilation (HP:0002883)1.77810762
109Epileptiform EEG discharges (HP:0011182)1.77611955
110Narrow forehead (HP:0000341)1.77391528
111EEG with generalized epileptiform discharges (HP:0011198)1.77271591
112Keratoconus (HP:0000563)1.76426316
113Increased corneal curvature (HP:0100692)1.76426316
114Abnormality of the lower motor neuron (HP:0002366)1.76262512
115Aplasia involving bones of the extremities (HP:0009825)1.75293760
116Aplasia involving bones of the upper limbs (HP:0009823)1.75293760
117Aplasia of the phalanges of the hand (HP:0009802)1.75293760
118True hermaphroditism (HP:0010459)1.75122019
119Pancreatic fibrosis (HP:0100732)1.75051918
120Intestinal atresia (HP:0011100)1.74706178
121Aplasia/Hypoplasia of the lens (HP:0008063)1.74508726
122Widely spaced teeth (HP:0000687)1.74361295
123Neuronal loss in central nervous system (HP:0002529)1.74332417
124Abnormality of the renal medulla (HP:0100957)1.73293878
125Poor coordination (HP:0002370)1.72916154
126Decreased muscle mass (HP:0003199)1.71786755
127Papillary thyroid carcinoma (HP:0002895)1.71488352
128Renal hypoplasia (HP:0000089)1.71225742
129Abnormal respiratory motile cilium physiology (HP:0012261)1.70637245
130Agitation (HP:0000713)1.70606769
131Absent septum pellucidum (HP:0001331)1.70525394
132Nasal speech (HP:0001611)1.70126769
133Anophthalmia (HP:0000528)1.70061919
134Failure to thrive in infancy (HP:0001531)1.69802039
135Fetal akinesia sequence (HP:0001989)1.69690182
136Leukodystrophy (HP:0002415)1.68585340
137Myelomeningocele (HP:0002475)1.68108078
138Hypoplasia of the corpus callosum (HP:0002079)1.67945151
139Micropenis (HP:0000054)1.67914022
140Hypoplastic pelvis (HP:0008839)1.67811082
141Anxiety (HP:0000739)1.67502634
142Truncal ataxia (HP:0002078)1.67159296
143Shoulder girdle muscle weakness (HP:0003547)1.65530886
144Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64207365
145Aqueductal stenosis (HP:0002410)1.63230173
146Blue irides (HP:0000635)1.63144586
147Supernumerary spleens (HP:0009799)1.62401150
148Medial flaring of the eyebrow (HP:0010747)1.62347686
149Hypoplastic female external genitalia (HP:0012815)1.61998158
150Bowel incontinence (HP:0002607)1.61466353
151Progressive macrocephaly (HP:0004481)1.61219221
152Anteriorly placed anus (HP:0001545)1.59955934
153Polymicrogyria (HP:0002126)1.57610832
154Abnormality of the hip-girdle musculature (HP:0001445)1.56168024
155Abnormality of the musculature of the pelvis (HP:0001469)1.56168024
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.55841804
157Pancreatic cysts (HP:0001737)1.55541587
158Broad foot (HP:0001769)1.53387661
159Delayed gross motor development (HP:0002194)1.52580052
160Anencephaly (HP:0002323)1.51888219
161Short foot (HP:0001773)1.51797413
162Oligodactyly (HP:0012165)1.51483176
163Decreased testicular size (HP:0008734)1.49806184
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.49764573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.43041782
2CASK3.27367821
3LIMK13.15399326
4STK393.05111485
5MAP3K92.70763111
6PNCK2.44099202
7WNK32.43709261
8NTRK32.41461887
9OXSR12.06664840
10MAP4K22.01068743
11BCR1.99848285
12MAPK131.98204882
13FGFR21.91865323
14TRIM281.86116974
15NTRK11.85170558
16TNIK1.84944219
17ARAF1.79473707
18UHMK11.76852738
19PLK21.76592068
20KSR21.72994958
21PKN11.72132190
22GRK51.70806054
23EPHA41.59895647
24NTRK21.56101832
25MINK11.56059950
26DYRK21.54142369
27MAPKAPK51.52620320
28PINK11.51498983
29MAP3K41.51330055
30PHKG11.44345142
31PHKG21.44345142
32MAP2K71.38909399
33DYRK31.32374261
34TESK11.31596961
35FGR1.31494823
36MAP3K21.28957932
37PAK61.27652895
38MAP3K121.25890318
39BMPR1B1.24785124
40EPHB11.21359404
41WNK41.16904714
42DAPK21.15665596
43CAMK2B1.15621296
44PTK2B1.15390841
45CDK51.14309076
46CSNK1G31.13553185
47SRPK11.11238949
48CSNK1A1L1.08603229
49PBK1.08283054
50WNK11.07782583
51TYRO31.06689049
52CSNK1G21.05848626
53MET1.05084591
54SGK2231.03547979
55SGK4941.03547979
56ROCK21.02431028
57CCNB11.01972777
58CDK141.01531964
59CAMK2A0.99582267
60NEK10.99117732
61RET0.94100213
62TIE10.94074706
63FES0.93447842
64PAK30.92323093
65MKNK10.91142438
66PRKCE0.90522458
67SIK20.85998969
68PRPF4B0.84649427
69CAMK2D0.84380682
70DYRK1B0.84179169
71LATS20.81252621
72MARK20.79973021
73CSNK1G10.76037090
74PLK30.75896716
75CDK180.74436041
76CDK150.73201846
77RIPK40.71597496
78CDK190.71115148
79STK38L0.69761435
80NUAK10.69536377
81CDK11A0.69084948
82MAP2K40.68609261
83STK160.68293172
84EPHB20.68289590
85MST40.68005819
86EPHA30.67346573
87MUSK0.67292010
88GRK70.66992485
89PDGFRA0.66970435
90NEK60.66272942
91MKNK20.65566717
92CAMK1G0.65127526
93KSR10.61532579
94FYN0.59612198
95FER0.59068850
96ADRBK10.57938647
97TSSK60.57507987
98VRK10.57024192
99CAMK2G0.54460104
100ADRBK20.53838700
101MAP2K10.52158734
102INSRR0.52108297
103PRKG10.50111685
104CAMKK20.49900060
105SGK20.49572886
106TAF10.48387313
107WEE10.47354035
108TESK20.47064178
109PRKCG0.46899312
110DYRK1A0.46307051
111DDR20.45015151
112ROCK10.44871882
113PRKCZ0.44605147
114IRAK20.44241900
115PTK20.44053829
116DAPK30.43865839
117PRKACB0.43073521
118TGFBR10.42736671
119CSNK1E0.42247103
120CDK30.42085751
121BRAF0.41277859
122MAPK150.41004527
123ERBB30.40321218
124PRKD30.39986482
125RPS6KA40.39853006
126MAP3K130.38862933
127ERBB20.38246535
128SRC0.37318961
129CSNK1A10.37194232
130NEK20.36737727
131PRKACA0.36702960
132BRSK10.36658104
133MYLK0.36494365
134YES10.36196412
135PRKCQ0.35869144
136SGK10.35784186
137PRKCH0.33487079

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.02891283
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.58830510
3Nicotine addiction_Homo sapiens_hsa050332.54436393
4Synaptic vesicle cycle_Homo sapiens_hsa047212.29483089
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20638929
6Axon guidance_Homo sapiens_hsa043602.20149277
7Serotonergic synapse_Homo sapiens_hsa047262.19333591
8Glutamatergic synapse_Homo sapiens_hsa047242.16148751
9GABAergic synapse_Homo sapiens_hsa047272.10004741
10Oxidative phosphorylation_Homo sapiens_hsa001902.07767019
11Morphine addiction_Homo sapiens_hsa050321.98109654
12Collecting duct acid secretion_Homo sapiens_hsa049661.94022459
13Circadian entrainment_Homo sapiens_hsa047131.92534665
14Long-term depression_Homo sapiens_hsa047301.80038279
15Dopaminergic synapse_Homo sapiens_hsa047281.74924829
16* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74540548
17Steroid biosynthesis_Homo sapiens_hsa001001.60714442
18Taste transduction_Homo sapiens_hsa047421.59768835
19Cholinergic synapse_Homo sapiens_hsa047251.59284449
20Long-term potentiation_Homo sapiens_hsa047201.56522724
21Alzheimers disease_Homo sapiens_hsa050101.56107346
22Olfactory transduction_Homo sapiens_hsa047401.50659716
23Parkinsons disease_Homo sapiens_hsa050121.48586279
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46049009
25Phototransduction_Homo sapiens_hsa047441.42415305
26Amphetamine addiction_Homo sapiens_hsa050311.41022669
27Salivary secretion_Homo sapiens_hsa049701.40270277
28Ether lipid metabolism_Homo sapiens_hsa005651.39577632
29Cardiac muscle contraction_Homo sapiens_hsa042601.33070029
30Hippo signaling pathway_Homo sapiens_hsa043901.29352295
31Basal transcription factors_Homo sapiens_hsa030221.28561582
32Basal cell carcinoma_Homo sapiens_hsa052171.27631613
33Cocaine addiction_Homo sapiens_hsa050301.27186298
34Vibrio cholerae infection_Homo sapiens_hsa051101.26937016
35Renin secretion_Homo sapiens_hsa049241.26823238
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25668963
37Butanoate metabolism_Homo sapiens_hsa006501.25283175
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24846397
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24788029
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24279564
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19372732
42Fatty acid elongation_Homo sapiens_hsa000621.19333236
43Insulin secretion_Homo sapiens_hsa049111.17275424
44Gastric acid secretion_Homo sapiens_hsa049711.16095512
45Gap junction_Homo sapiens_hsa045401.13557157
46Propanoate metabolism_Homo sapiens_hsa006401.13208139
47Dorso-ventral axis formation_Homo sapiens_hsa043201.12782001
48GnRH signaling pathway_Homo sapiens_hsa049121.10091898
49Renal cell carcinoma_Homo sapiens_hsa052111.09790465
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08120517
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07698601
52Rheumatoid arthritis_Homo sapiens_hsa053231.07579583
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05936080
54Oxytocin signaling pathway_Homo sapiens_hsa049211.03757046
55Melanogenesis_Homo sapiens_hsa049161.02747403
56ErbB signaling pathway_Homo sapiens_hsa040121.00635996
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.97878874
58Huntingtons disease_Homo sapiens_hsa050160.97593325
59Ras signaling pathway_Homo sapiens_hsa040140.95638024
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.95580179
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95182448
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.94075454
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92979851
64* Phagosome_Homo sapiens_hsa041450.92570362
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91873120
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91740912
67Sphingolipid metabolism_Homo sapiens_hsa006000.86834888
68Glioma_Homo sapiens_hsa052140.86640939
69Calcium signaling pathway_Homo sapiens_hsa040200.82516498
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82414237
71ECM-receptor interaction_Homo sapiens_hsa045120.80089120
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79239704
73Hedgehog signaling pathway_Homo sapiens_hsa043400.77943916
74Choline metabolism in cancer_Homo sapiens_hsa052310.77111406
75cAMP signaling pathway_Homo sapiens_hsa040240.74639437
76Estrogen signaling pathway_Homo sapiens_hsa049150.74545797
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72201422
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71120093
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70370677
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70036634
81Ribosome_Homo sapiens_hsa030100.68784674
82Pancreatic secretion_Homo sapiens_hsa049720.68119759
83Ovarian steroidogenesis_Homo sapiens_hsa049130.67635614
84TGF-beta signaling pathway_Homo sapiens_hsa043500.66127982
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65475859
86Alcoholism_Homo sapiens_hsa050340.63823860
87MAPK signaling pathway_Homo sapiens_hsa040100.62642060
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62381631
89Endocytosis_Homo sapiens_hsa041440.61131437
90Rap1 signaling pathway_Homo sapiens_hsa040150.60464459
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60388047
92beta-Alanine metabolism_Homo sapiens_hsa004100.59743602
93Mineral absorption_Homo sapiens_hsa049780.58622211
94Tight junction_Homo sapiens_hsa045300.58531761
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58226344
96VEGF signaling pathway_Homo sapiens_hsa043700.57143091
97Adherens junction_Homo sapiens_hsa045200.57067638
98Dilated cardiomyopathy_Homo sapiens_hsa054140.55514402
99Wnt signaling pathway_Homo sapiens_hsa043100.54031704
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53524777
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53516001
102Circadian rhythm_Homo sapiens_hsa047100.52868655
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52796108
104Autoimmune thyroid disease_Homo sapiens_hsa053200.52292972
105Melanoma_Homo sapiens_hsa052180.52209258
106Pyruvate metabolism_Homo sapiens_hsa006200.51959506
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51235845
108Prion diseases_Homo sapiens_hsa050200.50332859
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49499151
110Type II diabetes mellitus_Homo sapiens_hsa049300.49151002
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48104425
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46129896
113African trypanosomiasis_Homo sapiens_hsa051430.46026054
114Endometrial cancer_Homo sapiens_hsa052130.45783106
115Chemokine signaling pathway_Homo sapiens_hsa040620.45725116
116Fatty acid metabolism_Homo sapiens_hsa012120.45322281
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45237778
118* Salmonella infection_Homo sapiens_hsa051320.44766238
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44340961
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42486352
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42357705
122Folate biosynthesis_Homo sapiens_hsa007900.42335195
123RNA polymerase_Homo sapiens_hsa030200.41980905
124RNA degradation_Homo sapiens_hsa030180.41031640
125Colorectal cancer_Homo sapiens_hsa052100.40874029
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.40501168
127Protein digestion and absorption_Homo sapiens_hsa049740.39910415
128Regulation of autophagy_Homo sapiens_hsa041400.38710938
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.38654725
130Oocyte meiosis_Homo sapiens_hsa041140.37688002
131Tryptophan metabolism_Homo sapiens_hsa003800.36917707
132Fanconi anemia pathway_Homo sapiens_hsa034600.35221011
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34947695
134Metabolic pathways_Homo sapiens_hsa011000.33542947
135Peroxisome_Homo sapiens_hsa041460.33085738
136Spliceosome_Homo sapiens_hsa030400.30997705
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.30582218
138Nucleotide excision repair_Homo sapiens_hsa034200.30139760
139Sulfur metabolism_Homo sapiens_hsa009200.29878995
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29328094

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