ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.45989858
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.45989858
3	platelet dense granule organization (GO:0060155)	5.38865051
4	limb bud formation (GO:0060174)	4.79764126
5	opioid receptor signaling pathway (GO:0038003)	4.69984004
6	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.46734081
7	proteasome assembly (GO:0043248)	4.24963353
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.91855729
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.91855729
10	NADH dehydrogenase complex assembly (GO:0010257)	3.91855729
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.88103290
12	negative regulation of DNA biosynthetic process (GO:2000279)	3.79037258
13	gamma-aminobutyric acid transport (GO:0015812)	3.75640236
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.65854294
15	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.55585833
16	positive regulation of amino acid transport (GO:0051957)	3.53120739
17	behavioral response to nicotine (GO:0035095)	3.51853374
18	hindbrain development (GO:0030902)	3.51778111
19	microtubule nucleation (GO:0007020)	3.49503233
20	homocysteine metabolic process (GO:0050667)	3.49207186
21	cysteine metabolic process (GO:0006534)	3.39637366
22	protein complex biogenesis (GO:0070271)	3.33354409
23	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.29581348
24	ATP synthesis coupled proton transport (GO:0015986)	3.28208607
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.28208607
26	sequestering of actin monomers (GO:0042989)	3.24738405
27	sulfur amino acid catabolic process (GO:0000098)	3.24295977
28	regulation of plasminogen activation (GO:0010755)	3.24035370
29	adenosine metabolic process (GO:0046085)	3.22317462
30	somite development (GO:0061053)	3.21829722
31	retinal cone cell development (GO:0046549)	3.18160805
32	positive regulation of heat generation (GO:0031652)	3.12412503
33	vascular smooth muscle contraction (GO:0014829)	3.12063574
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.12033935
35	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.10906395
36	cornea development in camera-type eye (GO:0061303)	3.09886293
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.09610008
38	cAMP catabolic process (GO:0006198)	3.09564491
39	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.07596090
40	regulation of heat generation (GO:0031650)	3.04976404
41	neuroblast proliferation (GO:0007405)	3.03713551
42	regulation of fever generation (GO:0031620)	3.02327859
43	positive regulation of prostaglandin secretion (GO:0032308)	3.01610930
44	rRNA methylation (GO:0031167)	2.99803920
45	positive regulation of meiosis (GO:0045836)	2.98603932
46	metallo-sulfur cluster assembly (GO:0031163)	2.97481755
47	iron-sulfur cluster assembly (GO:0016226)	2.97481755
48	otic vesicle formation (GO:0030916)	2.95676578
49	pyrimidine nucleobase catabolic process (GO:0006208)	2.94841041
50	spliceosomal snRNP assembly (GO:0000387)	2.94563808
51	amino acid salvage (GO:0043102)	2.89435213
52	L-methionine salvage (GO:0071267)	2.89435213
53	L-methionine biosynthetic process (GO:0071265)	2.89435213
54	neurotransmitter catabolic process (GO:0042135)	2.87880787
55	positive regulation of meiotic cell cycle (GO:0051446)	2.86673427
56	rRNA modification (GO:0000154)	2.85996830
57	ribosome biogenesis (GO:0042254)	2.84719011
58	positive regulation of organic acid transport (GO:0032892)	2.83151383
59	mitochondrial RNA metabolic process (GO:0000959)	2.82936265
60	peptidyl-histidine modification (GO:0018202)	2.82587129
61	folic acid-containing compound biosynthetic process (GO:0009396)	2.82159275
62	protein-cofactor linkage (GO:0018065)	2.80704195
63	cartilage morphogenesis (GO:0060536)	2.80670854
64	sulfur amino acid biosynthetic process (GO:0000097)	2.76063784
65	primary amino compound metabolic process (GO:1901160)	2.74664028
66	viral mRNA export from host cell nucleus (GO:0046784)	2.73973062
67	protein-chromophore linkage (GO:0018298)	2.72602425
68	neurofilament cytoskeleton organization (GO:0060052)	2.71951211
69	cyclic nucleotide catabolic process (GO:0009214)	2.70088127
70	neural tube formation (GO:0001841)	2.68341978
71	somite rostral/caudal axis specification (GO:0032525)	2.65779084
72	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.61492153
73	regulation of prostaglandin secretion (GO:0032306)	2.60462792
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60138574
75	synaptic transmission, cholinergic (GO:0007271)	2.58960693
76	anterograde axon cargo transport (GO:0008089)	2.58605154
77	adult feeding behavior (GO:0008343)	2.56828054
78	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.54824032
79	microtubule depolymerization (GO:0007019)	2.54710343
80	negative regulation of response to nutrient levels (GO:0032108)	2.53663911
81	negative regulation of response to extracellular stimulus (GO:0032105)	2.53663911
82	GMP metabolic process (GO:0046037)	2.53219396
83	isoprenoid biosynthetic process (GO:0008299)	2.52037096
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.51693932
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.50791961
86	negative regulation of macroautophagy (GO:0016242)	2.50742216
87	purine nucleotide salvage (GO:0032261)	2.48940307
88	inner ear receptor cell development (GO:0060119)	2.48915911
89	single strand break repair (GO:0000012)	2.48782620
90	DNA deamination (GO:0045006)	2.47749770
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.45911208
92	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.45801353
93	indolalkylamine metabolic process (GO:0006586)	2.44393417
94	nucleobase catabolic process (GO:0046113)	2.42105263
95	axoneme assembly (GO:0035082)	2.41951300
96	cochlea development (GO:0090102)	2.41897084
97	dopaminergic neuron differentiation (GO:0071542)	2.40334690
98	photoreceptor cell development (GO:0042461)	2.40041868
99	heme transport (GO:0015886)	2.39914491
100	intracellular protein transmembrane import (GO:0044743)	2.39440599

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.60572923
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.67201475
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.41407084
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55540658
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50638960
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48342822
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.42064785
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31853546
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24785968
10	VDR_22108803_ChIP-Seq_LS180_Human	2.24292979
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.24184807
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16822731
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.13061285
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10987422
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.04537333
16	P300_19829295_ChIP-Seq_ESCs_Human	2.02773669
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02165583
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99674110
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90164579
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90012318
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.89383382
22	FUS_26573619_Chip-Seq_HEK293_Human	1.87568952
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.86192293
24	EWS_26573619_Chip-Seq_HEK293_Human	1.82337966
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79665571
26	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.75964342
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.73251480
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.70104925
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.67182575
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65155093
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.64415165
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60635973
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.53652346
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52323133
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49483821
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.47410393
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46301726
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42090033
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42090033
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40896658
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40371744
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40189587
43	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.39818736
44	AR_25329375_ChIP-Seq_VCAP_Human	1.38276467
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38093918
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37484111
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37167636
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37000674
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36448932
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33341765
51	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.31423115
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.30506969
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30506969
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29528623
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.25391473
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25231563
57	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24840991
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.20900264
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19074092
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17628454
61	CDX2_22108803_ChIP-Seq_LS180_Human	1.16917006
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16297388
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.14920701
64	STAT3_23295773_ChIP-Seq_U87_Human	1.14172695
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.14160931
66	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.14038711
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13879267
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13818743
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.12441220
70	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.12295416
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12239483
72	VDR_23849224_ChIP-Seq_CD4+_Human	1.11603909
73	IGF1R_20145208_ChIP-Seq_DFB_Human	1.09239783
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.09024346
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08485001
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08302264
77	TCF4_23295773_ChIP-Seq_U87_Human	1.06706775
78	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.06590960
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06260820
80	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06163291
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04919014
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03802313
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03802313
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02161985
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02161985
86	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01982559
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01865713
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01152942
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00148257
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.99368066
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98538740
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96917136
93	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96495063
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94467827
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94460223
96	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.94116626
97	KDM2B_26808549_Chip-Seq_REH_Human	0.93936759
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93375422
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92938456
100	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92800708

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.45158174
2	MP0005646_abnormal_pituitary_gland	3.55644678
3	MP0002735_abnormal_chemical_nociception	3.53109304
4	MP0003011_delayed_dark_adaptation	3.31724412
5	MP0003136_yellow_coat_color	2.92870329
6	MP0000569_abnormal_digit_pigmentation	2.74213743
7	MP0002638_abnormal_pupillary_reflex	2.45770311
8	MP0004885_abnormal_endolymph	2.41179977
9	MP0002234_abnormal_pharynx_morphology	2.40972849
10	MP0002736_abnormal_nociception_after	2.35164225
11	MP0005670_abnormal_white_adipose	2.31761540
12	MP0003283_abnormal_digestive_organ	2.22491672
13	MP0006292_abnormal_olfactory_placode	2.08250075
14	MP0005360_urolithiasis	2.07500723
15	MP0002938_white_spotting	2.04432997
16	MP0005551_abnormal_eye_electrophysiolog	2.02061454
17	MP0001968_abnormal_touch/_nociception	1.93761950
18	MP0005253_abnormal_eye_physiology	1.82444049
19	MP0003880_abnormal_central_pattern	1.80260582
20	MP0008872_abnormal_physiological_respon	1.76343392
21	MP0006276_abnormal_autonomic_nervous	1.76038520
22	MP0002282_abnormal_trachea_morphology	1.72263014
23	MP0006072_abnormal_retinal_apoptosis	1.71022919
24	MP0003890_abnormal_embryonic-extraembry	1.70284858
25	MP0009745_abnormal_behavioral_response	1.69806496
26	MP0005171_absent_coat_pigmentation	1.66410366
27	MP0002095_abnormal_skin_pigmentation	1.58660621
28	MP0008877_abnormal_DNA_methylation	1.56681169
29	MP0000647_abnormal_sebaceous_gland	1.53970245
30	MP0002751_abnormal_autonomic_nervous	1.50863757
31	MP0002822_catalepsy	1.48615270
32	MP0002837_dystrophic_cardiac_calcinosis	1.44568253
33	MP0009697_abnormal_copulation	1.42352981
34	MP0002160_abnormal_reproductive_system	1.40466168
35	MP0004215_abnormal_myocardial_fiber	1.37925589
36	MP0001486_abnormal_startle_reflex	1.37098354
37	MP0003718_maternal_effect	1.35722071
38	MP0008995_early_reproductive_senescence	1.32695081
39	MP0000371_diluted_coat_color	1.31017712
40	MP0000631_abnormal_neuroendocrine_gland	1.30697828
41	MP0000026_abnormal_inner_ear	1.29789339
42	MP0001970_abnormal_pain_threshold	1.23583475
43	MP0001984_abnormal_olfaction	1.22074886
44	MP0000778_abnormal_nervous_system	1.20000463
45	MP0002272_abnormal_nervous_system	1.19862659
46	MP0004142_abnormal_muscle_tone	1.17813578
47	MP0004043_abnormal_pH_regulation	1.15333214
48	MP0002733_abnormal_thermal_nociception	1.14125053
49	MP0002752_abnormal_somatic_nervous	1.13100862
50	MP0010386_abnormal_urinary_bladder	1.11957385
51	MP0001963_abnormal_hearing_physiology	1.11838029
52	MP0002734_abnormal_mechanical_nocicepti	1.11491212
53	MP0005195_abnormal_posterior_eye	1.11460007
54	MP0004145_abnormal_muscle_electrophysio	1.10614029
55	MP0008875_abnormal_xenobiotic_pharmacok	1.09972805
56	MP0003119_abnormal_digestive_system	1.09639003
57	MP0004742_abnormal_vestibular_system	1.08618387
58	MP0002075_abnormal_coat/hair_pigmentati	1.07262801
59	MP0003186_abnormal_redox_activity	1.07239017
60	MP0000049_abnormal_middle_ear	1.06581940
61	MP0001485_abnormal_pinna_reflex	1.05813020
62	MP0003635_abnormal_synaptic_transmissio	1.04508804
63	MP0002557_abnormal_social/conspecific_i	1.04508574
64	MP0001293_anophthalmia	1.03947408
65	MP0002064_seizures	1.03211738
66	MP0005085_abnormal_gallbladder_physiolo	1.03065716
67	MP0005367_renal/urinary_system_phenotyp	1.01865896
68	MP0000516_abnormal_urinary_system	1.01865896
69	MP0003195_calcinosis	0.96537062
70	MP0004924_abnormal_behavior	0.92214858
71	MP0005386_behavior/neurological_phenoty	0.92214858
72	MP0009046_muscle_twitch	0.91398688
73	MP0002277_abnormal_respiratory_mucosa	0.91075169
74	MP0001764_abnormal_homeostasis	0.89376951
75	MP0004147_increased_porphyrin_level	0.88738036
76	MP0001905_abnormal_dopamine_level	0.87331583
77	MP0001440_abnormal_grooming_behavior	0.85878392
78	MP0000538_abnormal_urinary_bladder	0.85797066
79	MP0004270_analgesia	0.85630439
80	MP0005084_abnormal_gallbladder_morpholo	0.84614078
81	MP0004272_abnormal_basement_membrane	0.84540547
82	MP0008789_abnormal_olfactory_epithelium	0.84272837
83	MP0000013_abnormal_adipose_tissue	0.83622481
84	MP0002184_abnormal_innervation	0.83586993
85	MP0008058_abnormal_DNA_repair	0.83521047
86	MP0002069_abnormal_eating/drinking_beha	0.83122555
87	MP0004133_heterotaxia	0.83092181
88	MP0005391_vision/eye_phenotype	0.82875316
89	MP0001286_abnormal_eye_development	0.81804079
90	MP0001529_abnormal_vocalization	0.80841388
91	MP0001661_extended_life_span	0.79034144
92	MP0002572_abnormal_emotion/affect_behav	0.78396038
93	MP0003755_abnormal_palate_morphology	0.78384486
94	MP0001986_abnormal_taste_sensitivity	0.78261765
95	MP0001270_distended_abdomen	0.77674556
96	MP0004019_abnormal_vitamin_homeostasis	0.76693421
97	MP0005448_abnormal_energy_balance	0.76228272
98	MP0001186_pigmentation_phenotype	0.76145267
99	MP0005075_abnormal_melanosome_morpholog	0.76035357
100	MP0003937_abnormal_limbs/digits/tail_de	0.75678077

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.21989830
2	Abnormality of alanine metabolism (HP:0010916)	4.21989830
3	Hyperalaninemia (HP:0003348)	4.21989830
4	Type II lissencephaly (HP:0007260)	3.99287652
5	Retinal dysplasia (HP:0007973)	3.87419386
6	Constricted visual fields (HP:0001133)	3.64455724
7	Focal motor seizures (HP:0011153)	3.20001730
8	Medial flaring of the eyebrow (HP:0010747)	3.13108440
9	Bilateral microphthalmos (HP:0007633)	3.01694371
10	Agitation (HP:0000713)	2.95782680
11	Acute necrotizing encephalopathy (HP:0006965)	2.94071387
12	Oligomenorrhea (HP:0000876)	2.87026550
13	Gait imbalance (HP:0002141)	2.86748896
14	Pendular nystagmus (HP:0012043)	2.82273650
15	True hermaphroditism (HP:0010459)	2.81356364
16	Type 2 muscle fiber atrophy (HP:0003554)	2.81174473
17	Abnormality of the labia minora (HP:0012880)	2.75710041
18	Acute encephalopathy (HP:0006846)	2.75223521
19	3-Methylglutaconic aciduria (HP:0003535)	2.73055448
20	Congenital sensorineural hearing impairment (HP:0008527)	2.70600513
21	Calf muscle hypertrophy (HP:0008981)	2.69050054
22	Pancreatic fibrosis (HP:0100732)	2.68365115
23	Maternal diabetes (HP:0009800)	2.67204209
24	Reticulocytopenia (HP:0001896)	2.65803420
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.64347696
26	Congenital primary aphakia (HP:0007707)	2.63418565
27	Nephrogenic diabetes insipidus (HP:0009806)	2.63310394
28	Hypothermia (HP:0002045)	2.62812583
29	Mitochondrial inheritance (HP:0001427)	2.58610817
30	Pancreatic cysts (HP:0001737)	2.53402550
31	Progressive macrocephaly (HP:0004481)	2.52137792
32	Generalized aminoaciduria (HP:0002909)	2.51433147
33	Genital tract atresia (HP:0001827)	2.50722263
34	Methylmalonic aciduria (HP:0012120)	2.49034074
35	Keratoconus (HP:0000563)	2.47731934
36	Increased corneal curvature (HP:0100692)	2.47731934
37	Increased CSF lactate (HP:0002490)	2.47280785
38	Duplicated collecting system (HP:0000081)	2.46193071
39	Lissencephaly (HP:0001339)	2.39703838
40	Muscle hypertrophy of the lower extremities (HP:0008968)	2.38211621
41	Increased serum pyruvate (HP:0003542)	2.36985110
42	Abnormality of the renal collecting system (HP:0004742)	2.36948047
43	Optic disc pallor (HP:0000543)	2.36119834
44	Vaginal atresia (HP:0000148)	2.30805481
45	Anencephaly (HP:0002323)	2.29278780
46	Increased hepatocellular lipid droplets (HP:0006565)	2.27391292
47	Abolished electroretinogram (ERG) (HP:0000550)	2.27253786
48	Abnormal mitochondria in muscle tissue (HP:0008316)	2.24508765
49	Intestinal atresia (HP:0011100)	2.23960585
50	Molar tooth sign on MRI (HP:0002419)	2.20918428
51	Abnormality of midbrain morphology (HP:0002418)	2.20918428
52	Renal Fanconi syndrome (HP:0001994)	2.19863814
53	Renal cortical cysts (HP:0000803)	2.17295456
54	Methylmalonic acidemia (HP:0002912)	2.16980742
55	Spinal muscular atrophy (HP:0007269)	2.16445577
56	Metaphyseal dysplasia (HP:0100255)	2.15819442
57	Concave nail (HP:0001598)	2.14730496
58	Muscle fiber atrophy (HP:0100295)	2.11192471
59	Attenuation of retinal blood vessels (HP:0007843)	2.10125048
60	Abnormality of homocysteine metabolism (HP:0010919)	2.09369263
61	Homocystinuria (HP:0002156)	2.09369263
62	Striae distensae (HP:0001065)	2.09081343
63	Septo-optic dysplasia (HP:0100842)	2.08469041
64	Optic nerve hypoplasia (HP:0000609)	2.06975891
65	Abnormality of serum amino acid levels (HP:0003112)	2.06371231
66	Lipid accumulation in hepatocytes (HP:0006561)	2.05223633
67	Cerebral edema (HP:0002181)	2.01905147
68	Anophthalmia (HP:0000528)	2.00543689
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00177252
70	Congenital, generalized hypertrichosis (HP:0004540)	1.99222734
71	Brittle hair (HP:0002299)	1.98211745
72	Focal seizures (HP:0007359)	1.94898321
73	Nephronophthisis (HP:0000090)	1.92959249
74	Abnormality of DNA repair (HP:0003254)	1.90376672
75	Limb dystonia (HP:0002451)	1.88600344
76	Inability to walk (HP:0002540)	1.88011778
77	Hyperglycinemia (HP:0002154)	1.86440633
78	Increased serum lactate (HP:0002151)	1.82901145
79	Abnormal umbilical cord blood vessels (HP:0011403)	1.79946994
80	Single umbilical artery (HP:0001195)	1.79946994
81	Abnormality of the fetal cardiovascular system (HP:0010948)	1.79946994
82	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78107342
83	Abnormality of glycolysis (HP:0004366)	1.75962927
84	Abnormality of the renal cortex (HP:0011035)	1.75481799
85	Postaxial hand polydactyly (HP:0001162)	1.74644553
86	Abnormality of renal resorption (HP:0011038)	1.74143704
87	Chorioretinal atrophy (HP:0000533)	1.73800835
88	Specific learning disability (HP:0001328)	1.72618779
89	Lactic acidosis (HP:0003128)	1.72122784
90	Absent septum pellucidum (HP:0001331)	1.71954358
91	Exertional dyspnea (HP:0002875)	1.69541516
92	Dandy-Walker malformation (HP:0001305)	1.69103836
93	Shoulder girdle muscle weakness (HP:0003547)	1.69070679
94	Poor coordination (HP:0002370)	1.68027503
95	Hemiparesis (HP:0001269)	1.65864970
96	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.65835091
97	Hypomagnesemia (HP:0002917)	1.65651810
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.65133989
99	Opisthotonus (HP:0002179)	1.64618805
100	Cerebral hypomyelination (HP:0006808)	1.64574908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.89595171
2	TAF1	3.80202540
3	CASK	3.25385548
4	MAP4K2	3.14064036
5	NUAK1	2.84365118
6	TRIM28	2.76767070
7	VRK1	2.66446879
8	CDK19	2.66189627
9	ZAK	2.44536610
10	ACVR1B	2.34742159
11	STK16	2.20677021
12	MARK1	1.99531066
13	MKNK1	1.99224082
14	FRK	1.94368821
15	CCNB1	1.94147686
16	DYRK3	1.89407935
17	BCKDK	1.78230200
18	CSNK1G3	1.67202390
19	PNCK	1.66988393
20	CSNK1G2	1.66760508
21	BCR	1.66266318
22	DYRK2	1.62557224
23	WEE1	1.62362161
24	PLK3	1.58372992
25	NTRK2	1.57220415
26	STK39	1.46952699
27	TIE1	1.43594693
28	OXSR1	1.42536013
29	MAPK13	1.41219930
30	MAPKAPK5	1.41121732
31	CSNK1G1	1.39425085
32	CSNK1A1L	1.29234120
33	BMPR1B	1.28147577
34	PINK1	1.17322664
35	MST4	1.15317783
36	EPHB2	1.15042442
37	MAP2K7	1.08392348
38	MUSK	1.02429929
39	TSSK6	1.01619284
40	WNK3	1.00934720
41	ADRBK2	1.00504248
42	CDK9	0.99465122
43	EPHA4	0.98920518
44	TLK1	0.95175046
45	MAPK15	0.94241787
46	BUB1	0.86246950
47	ADRBK1	0.84199839
48	TESK1	0.83009934
49	EIF2AK2	0.81981513
50	MAP3K4	0.79261524
51	MKNK2	0.74656049
52	PHKG1	0.73413402
53	PHKG2	0.73413402
54	MINK1	0.71274542
55	PLK2	0.67706953
56	GRK1	0.67380828
57	MAP3K3	0.66212572
58	TGFBR1	0.65149991
59	PKN1	0.65067775
60	FGR	0.64476661
61	GRK5	0.61473172
62	TXK	0.61018664
63	CSNK1A1	0.60861318
64	INSRR	0.60260663
65	PRKCG	0.59854683
66	PRKCE	0.58885467
67	PAK3	0.56819566
68	AURKA	0.54122036
69	IRAK1	0.53114731
70	DYRK1A	0.51934245
71	CAMK2A	0.51811025
72	PASK	0.48656954
73	MYLK	0.46632692
74	MAPKAPK3	0.45925715
75	RPS6KA5	0.42775694
76	PRKCI	0.41991112
77	GRK7	0.41521679
78	FER	0.40607446
79	CDC7	0.39589176
80	PRKACA	0.38176551
81	CAMK2D	0.37300789
82	PLK1	0.36777579
83	OBSCN	0.36667889
84	CHEK2	0.34875789
85	CDK3	0.33290695
86	STK11	0.32786648
87	PLK4	0.30975102
88	PBK	0.30496538
89	NEK1	0.30412002
90	CSNK2A2	0.29209200
91	CDK5	0.29175486
92	DMPK	0.28330677
93	CAMK2B	0.27823539
94	NME1	0.26933326
95	DAPK1	0.26254909
96	SRPK1	0.26108620
97	PRKCQ	0.25925838
98	PRKCA	0.24267216
99	CSNK1D	0.24175964
100	ERBB3	0.24044335

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.87405397
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19236590
3	Proteasome_Homo sapiens_hsa03050	2.88436415
4	One carbon pool by folate_Homo sapiens_hsa00670	2.75584715
5	Parkinsons disease_Homo sapiens_hsa05012	2.54418471
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.41022577
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.18010050
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.15821980
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90763541
10	Morphine addiction_Homo sapiens_hsa05032	1.86733357
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85256127
12	Sulfur metabolism_Homo sapiens_hsa00920	1.82688311
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.80882539
14	GABAergic synapse_Homo sapiens_hsa04727	1.76808731
15	RNA polymerase_Homo sapiens_hsa03020	1.72026456
16	Propanoate metabolism_Homo sapiens_hsa00640	1.68114812
17	Huntingtons disease_Homo sapiens_hsa05016	1.67282981
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65518267
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61253281
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.59717613
21	Basal transcription factors_Homo sapiens_hsa03022	1.59443482
22	Ribosome_Homo sapiens_hsa03010	1.57467345
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.56412804
24	Alzheimers disease_Homo sapiens_hsa05010	1.55164069
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.55065586
26	Nicotine addiction_Homo sapiens_hsa05033	1.54317845
27	Regulation of autophagy_Homo sapiens_hsa04140	1.47316783
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40375138
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39331203
30	RNA transport_Homo sapiens_hsa03013	1.36328619
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35966233
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.32851051
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29826689
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.28727722
35	RNA degradation_Homo sapiens_hsa03018	1.26525630
36	Arginine biosynthesis_Homo sapiens_hsa00220	1.25883018
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14091347
38	Purine metabolism_Homo sapiens_hsa00230	1.13316498
39	Homologous recombination_Homo sapiens_hsa03440	1.10183073
40	Butanoate metabolism_Homo sapiens_hsa00650	1.09406801
41	Peroxisome_Homo sapiens_hsa04146	1.08928449
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08370989
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.04544178
44	Phototransduction_Homo sapiens_hsa04744	1.04535576
45	Taste transduction_Homo sapiens_hsa04742	1.02371545
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99036421
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.98768785
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96141053
49	Olfactory transduction_Homo sapiens_hsa04740	0.93435834
50	Spliceosome_Homo sapiens_hsa03040	0.92328624
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.91055406
52	Circadian entrainment_Homo sapiens_hsa04713	0.90339288
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.88464213
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84182632
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82469698
56	Vibrio cholerae infection_Homo sapiens_hsa05110	0.82398485
57	Serotonergic synapse_Homo sapiens_hsa04726	0.81478349
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81466444
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.76248707
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75869834
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72996333
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71554670
63	Retinol metabolism_Homo sapiens_hsa00830	0.71212592
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70262231
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.67474896
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.66498443
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.66330218
68	Metabolic pathways_Homo sapiens_hsa01100	0.66118914
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.65834427
70	Caffeine metabolism_Homo sapiens_hsa00232	0.65206963
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64114452
72	Histidine metabolism_Homo sapiens_hsa00340	0.62900401
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62535015
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57863984
75	Fatty acid elongation_Homo sapiens_hsa00062	0.57483051
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.56939646
77	Salivary secretion_Homo sapiens_hsa04970	0.55848544
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.54194004
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53698090
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48787205
81	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47573449
82	Folate biosynthesis_Homo sapiens_hsa00790	0.44221288
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44025238
84	Oocyte meiosis_Homo sapiens_hsa04114	0.42871623
85	Cell cycle_Homo sapiens_hsa04110	0.42646270
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41635648
87	Cholinergic synapse_Homo sapiens_hsa04725	0.38733068
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.37244769
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36050273
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34604468
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34435030
92	p53 signaling pathway_Homo sapiens_hsa04115	0.34071945
93	Cocaine addiction_Homo sapiens_hsa05030	0.33968148
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32289039
95	Alcoholism_Homo sapiens_hsa05034	0.31360677
96	ABC transporters_Homo sapiens_hsa02010	0.31352816
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30567312
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.30244559
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.29161048
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.27748685

DYNC1I2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »