DYNC2H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.61460466
2axonemal dynein complex assembly (GO:0070286)6.68290716
3cilium movement (GO:0003341)6.66012363
4epithelial cilium movement (GO:0003351)5.82268865
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.74161931
6piRNA metabolic process (GO:0034587)5.45875287
7* intraciliary transport (GO:0042073)5.11696974
8axoneme assembly (GO:0035082)4.83984076
9male meiosis (GO:0007140)4.83609201
10ventricular system development (GO:0021591)4.80533668
11melanin biosynthetic process (GO:0042438)4.62672533
12motile cilium assembly (GO:0044458)4.42423294
13sperm motility (GO:0030317)4.28836370
14secondary metabolite biosynthetic process (GO:0044550)4.20539129
15acrosome assembly (GO:0001675)4.18135037
16synaptonemal complex organization (GO:0070193)4.16095150
17protein localization to cilium (GO:0061512)4.13851579
18melanin metabolic process (GO:0006582)4.03066820
19regulation of cilium movement (GO:0003352)3.85902397
20* cilium organization (GO:0044782)3.80591578
21DNA methylation involved in gamete generation (GO:0043046)3.78176728
22fusion of sperm to egg plasma membrane (GO:0007342)3.71463919
23synaptonemal complex assembly (GO:0007130)3.70007653
24detection of calcium ion (GO:0005513)3.68450315
25* cilium assembly (GO:0042384)3.67363789
26spermatid development (GO:0007286)3.59605389
27acrosome reaction (GO:0007340)3.50035137
28negative regulation of inclusion body assembly (GO:0090084)3.28514771
29sperm-egg recognition (GO:0035036)3.26832323
30multicellular organism reproduction (GO:0032504)3.26187002
31cilium morphogenesis (GO:0060271)3.25072451
32regulation of DNA endoreduplication (GO:0032875)3.24076396
33male meiosis I (GO:0007141)3.21620454
34nonmotile primary cilium assembly (GO:0035058)3.19293755
35left/right axis specification (GO:0070986)3.15671464
36lactate metabolic process (GO:0006089)3.11628438
37* microtubule-based movement (GO:0007018)3.10732808
38nuclear pore complex assembly (GO:0051292)3.06545309
39* cellular component assembly involved in morphogenesis (GO:0010927)3.05690483
40protein targeting to Golgi (GO:0000042)3.05634164
41appendage development (GO:0048736)3.04085048
42limb development (GO:0060173)3.04085048
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03545540
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02689661
45mitotic sister chromatid cohesion (GO:0007064)3.01042290
46nuclear pore organization (GO:0006999)3.00757614
47centriole replication (GO:0007099)3.00702628
48binding of sperm to zona pellucida (GO:0007339)3.00143499
49plasma membrane fusion (GO:0045026)2.95158806
50cerebellar Purkinje cell differentiation (GO:0021702)2.91791993
51establishment of protein localization to Golgi (GO:0072600)2.90798211
52retinal rod cell development (GO:0046548)2.90121811
53calcium ion-dependent exocytosis (GO:0017156)2.88668085
54cell-cell recognition (GO:0009988)2.87391555
55regulation of microtubule-based movement (GO:0060632)2.85141524
56retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84614039
57calcium ion import (GO:0070509)2.82534890
58chromatin remodeling at centromere (GO:0031055)2.82497172
59CENP-A containing nucleosome assembly (GO:0034080)2.82082406
60kinetochore organization (GO:0051383)2.81258587
61intra-S DNA damage checkpoint (GO:0031573)2.79127819
62smoothened signaling pathway (GO:0007224)2.78517892
63photoreceptor cell maintenance (GO:0045494)2.78247580
64startle response (GO:0001964)2.75728612
65innervation (GO:0060384)2.73710149
66protein localization to synapse (GO:0035418)2.73352606
67insulin secretion (GO:0030073)2.72629320
68synaptic vesicle exocytosis (GO:0016079)2.71463960
69inner ear receptor cell development (GO:0060119)2.69205305
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68597116
71centrosome duplication (GO:0051298)2.66720983
72regulation of centriole replication (GO:0046599)2.65534535
73artery development (GO:0060840)2.62535590
74left/right pattern formation (GO:0060972)2.61514954
75metaphase plate congression (GO:0051310)2.60416659
76dorsal/ventral axis specification (GO:0009950)2.59774460
77meiotic nuclear division (GO:0007126)2.59625468
78negative regulation of DNA-dependent DNA replication (GO:2000104)2.59472879
79presynaptic membrane assembly (GO:0097105)2.59457538
80resolution of meiotic recombination intermediates (GO:0000712)2.58755272
81regulation of meiosis I (GO:0060631)2.58550996
82photoreceptor cell development (GO:0042461)2.58172047
83chromosome organization involved in meiosis (GO:0070192)2.57897199
84centriole assembly (GO:0098534)2.57219695
85single fertilization (GO:0007338)2.56871157
86regulation of spindle organization (GO:0090224)2.56174286
87phosphorelay signal transduction system (GO:0000160)2.55684327
88neuron cell-cell adhesion (GO:0007158)2.55390903
89regulation of centrosome cycle (GO:0046605)2.54521438
90eye photoreceptor cell development (GO:0042462)2.53858251
91histone exchange (GO:0043486)2.52870308
92genitalia morphogenesis (GO:0035112)2.52119175
93regulation of synaptic vesicle exocytosis (GO:2000300)2.52093642
94establishment of nucleus localization (GO:0040023)2.52081650
95eye photoreceptor cell differentiation (GO:0001754)2.51718935
96photoreceptor cell differentiation (GO:0046530)2.51718935
97intra-Golgi vesicle-mediated transport (GO:0006891)2.50979445
98microtubule bundle formation (GO:0001578)2.50629031
99regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50107566
100striatum development (GO:0021756)2.49447166
101spindle checkpoint (GO:0031577)2.49229207
102protein localization to kinetochore (GO:0034501)2.48993695
103protein polyglutamylation (GO:0018095)2.48831213
104hindbrain development (GO:0030902)2.47980501
105kinetochore assembly (GO:0051382)2.46628724
106replication fork processing (GO:0031297)2.46547852
107microtubule depolymerization (GO:0007019)2.46072089
108membrane depolarization during action potential (GO:0086010)2.45778164
109regulation of centrosome duplication (GO:0010824)2.44742534
110microtubule anchoring (GO:0034453)2.43756927
111retinal cone cell development (GO:0046549)2.43724175
112sister chromatid segregation (GO:0000819)2.43671483
113positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40027758
114locomotory exploration behavior (GO:0035641)2.39688726
115fertilization (GO:0009566)2.39569743
116GTP biosynthetic process (GO:0006183)2.39470703
117reproduction (GO:0000003)2.39241843
118synaptic transmission, glutamatergic (GO:0035249)2.38980327
119neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.38582012
120positive regulation of meiosis (GO:0045836)2.38043684
121retina layer formation (GO:0010842)2.37690954
122regulation of mitotic spindle organization (GO:0060236)2.36856931
123behavioral response to ethanol (GO:0048149)2.36491864
124postsynaptic membrane organization (GO:0001941)2.36465456
125meiosis I (GO:0007127)2.36047538
126nucleus localization (GO:0051647)2.34887722
127mitotic sister chromatid segregation (GO:0000070)2.34662301
128interkinetic nuclear migration (GO:0022027)2.34353289
129paraxial mesoderm development (GO:0048339)2.33231412
130* determination of bilateral symmetry (GO:0009855)2.31615260
131* determination of left/right symmetry (GO:0007368)2.31556866
132cell wall macromolecule catabolic process (GO:0016998)2.31515006
133cell wall macromolecule metabolic process (GO:0044036)2.31515006
134lateral sprouting from an epithelium (GO:0060601)2.30589536
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.30480979
136regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29856176
137protein localization to Golgi apparatus (GO:0034067)2.29487517
138germ cell development (GO:0007281)2.29087414
139regulation of synaptic vesicle transport (GO:1902803)2.29079678
140protein K6-linked ubiquitination (GO:0085020)2.28395593
141* specification of symmetry (GO:0009799)2.27347204
142microtubule polymerization or depolymerization (GO:0031109)2.27301762
143axon extension involved in axon guidance (GO:0048846)2.27188702
144neuron projection extension involved in neuron projection guidance (GO:1902284)2.27188702
145retinal ganglion cell axon guidance (GO:0031290)2.26863129
146establishment of planar polarity (GO:0001736)2.26456082
147establishment of tissue polarity (GO:0007164)2.26456082
148non-recombinational repair (GO:0000726)2.23877003
149double-strand break repair via nonhomologous end joining (GO:0006303)2.23877003
150establishment of chromosome localization (GO:0051303)2.23740906
151mitotic metaphase plate congression (GO:0007080)2.23372838
152pore complex assembly (GO:0046931)2.22965464
153ventricular cardiac muscle cell development (GO:0055015)2.22710309
154negative regulation of JUN kinase activity (GO:0043508)2.21103320
155mitotic spindle checkpoint (GO:0071174)2.19224827
156synapsis (GO:0007129)2.18174089
157centrosome organization (GO:0051297)2.17265928
158microtubule organizing center organization (GO:0031023)2.16661659
159negative regulation of axon guidance (GO:1902668)2.14323680
160lateral ventricle development (GO:0021670)2.13702206
161DNA replication-independent nucleosome organization (GO:0034724)2.13505116
162DNA replication-independent nucleosome assembly (GO:0006336)2.13505116
163sister chromatid cohesion (GO:0007062)2.13405106
164regulation of sister chromatid segregation (GO:0033045)2.12371707
165regulation of mitotic sister chromatid separation (GO:0010965)2.12371707
166regulation of mitotic sister chromatid segregation (GO:0033047)2.12371707
167regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.12072436
168regulation of mitotic metaphase/anaphase transition (GO:0030071)2.12072436
169regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.11723326
170phenol-containing compound biosynthetic process (GO:0046189)2.11227458
171response to X-ray (GO:0010165)2.09450382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56859642
2GBX2_23144817_ChIP-Seq_PC3_Human3.38967945
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96008647
4E2F7_22180533_ChIP-Seq_HELA_Human2.71878405
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.62085111
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54668159
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36417062
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28930715
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28588689
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.26458750
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18529751
12* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07381649
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03411635
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02689473
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01648478
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94547799
17* SMAD4_21799915_ChIP-Seq_A2780_Human1.93035485
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88057437
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83423811
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.82444492
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82323021
22REST_21632747_ChIP-Seq_MESCs_Mouse1.77532130
23* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76006462
24* FUS_26573619_Chip-Seq_HEK293_Human1.75432587
25ZNF274_21170338_ChIP-Seq_K562_Hela1.75376518
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.74842375
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73368827
28TAF15_26573619_Chip-Seq_HEK293_Human1.71399617
29AR_21909140_ChIP-Seq_LNCAP_Human1.71182758
30IGF1R_20145208_ChIP-Seq_DFB_Human1.70909987
31RNF2_27304074_Chip-Seq_NSC_Mouse1.70456870
32* P300_19829295_ChIP-Seq_ESCs_Human1.70143755
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69787377
34STAT3_23295773_ChIP-Seq_U87_Human1.67311926
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66552087
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.66354345
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63958748
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63209367
39* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61876572
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60875702
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.60678705
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59916872
43* TCF4_23295773_ChIP-Seq_U87_Human1.59073507
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58893921
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.57406233
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.57350026
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55039519
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54287956
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54177312
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.53574628
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53523066
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53292874
53VDR_22108803_ChIP-Seq_LS180_Human1.49558027
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48983104
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46761376
56DROSHA_22980978_ChIP-Seq_HELA_Human1.45600409
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43627947
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43604124
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43174383
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43174383
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42656241
62ER_23166858_ChIP-Seq_MCF-7_Human1.42507292
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40648336
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38857722
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.36923485
66EWS_26573619_Chip-Seq_HEK293_Human1.36654701
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36566301
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.34951568
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33595219
70P53_22387025_ChIP-Seq_ESCs_Mouse1.33480670
71BCAT_22108803_ChIP-Seq_LS180_Human1.33092848
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32448639
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32029690
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.31869210
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31065991
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30580954
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.30560257
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.29836040
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29033355
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28905533
81TP53_16413492_ChIP-PET_HCT116_Human1.28387558
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28197840
83ELK1_19687146_ChIP-ChIP_HELA_Human1.27936843
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27795963
85AHR_22903824_ChIP-Seq_MCF-7_Human1.27006311
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26634678
87AR_25329375_ChIP-Seq_VCAP_Human1.22950571
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.21971393
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21202440
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21067860
91P300_18555785_Chip-Seq_ESCs_Mouse1.20731157
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.20359612
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.19443401
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19191638
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18810474
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18645890
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18645890
98RUNX2_22187159_ChIP-Seq_PCA_Human1.18610937
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18461255
100TCF4_22108803_ChIP-Seq_LS180_Human1.18132262
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17999222
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17902861
103* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17878040
104* CBP_20019798_ChIP-Seq_JUKART_Human1.17878040
105TBL1_22424771_ChIP-Seq_293T_Human1.17862181
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17529688
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17420415
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16960646
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.16693615
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16668822
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.16620234
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16434477
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16261918
114SOX9_26525672_Chip-Seq_HEART_Mouse1.15969867
115TP53_18474530_ChIP-ChIP_U2OS_Human1.15764743
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15366794
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15179365
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14394555
119EP300_21415370_ChIP-Seq_HL-1_Mouse1.13642519
120* TAL1_26923725_Chip-Seq_HPCs_Mouse1.12964125
121AR_21572438_ChIP-Seq_LNCaP_Human1.12825374
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.11231468
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11088613
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11088613
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09081138
126JUN_21703547_ChIP-Seq_K562_Human1.07206969
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07077120
128* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05700628
129NFYB_21822215_ChIP-Seq_K562_Human1.04782593
130CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03467402
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03136256
132TRIM28_21343339_ChIP-Seq_HEK293_Human1.02349602
133KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01960006
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00329009
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99417228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.76337922
2MP0008877_abnormal_DNA_methylation3.38442879
3MP0005410_abnormal_fertilization3.33294865
4MP0003122_maternal_imprinting2.58673682
5MP0006072_abnormal_retinal_apoptosis2.55200313
6MP0005646_abnormal_pituitary_gland2.53495094
7MP0003787_abnormal_imprinting2.50550720
8MP0002102_abnormal_ear_morphology2.43921144
9MP0005408_hypopigmentation2.41808828
10MP0009780_abnormal_chondrocyte_physiolo2.37457281
11MP0010030_abnormal_orbit_morphology2.31765640
12MP0001984_abnormal_olfaction2.28191719
13MP0005551_abnormal_eye_electrophysiolog2.26209370
14MP0004859_abnormal_synaptic_plasticity2.24501472
15MP0009046_muscle_twitch2.23762564
16MP0003880_abnormal_central_pattern2.19275179
17MP0005248_abnormal_Harderian_gland2.17064904
18MP0003635_abnormal_synaptic_transmissio2.01390385
19MP0003698_abnormal_male_reproductive1.99234770
20MP0003121_genomic_imprinting1.95851412
21MP0004270_analgesia1.95727628
22MP0002653_abnormal_ependyma_morphology1.92286843
23MP0000569_abnormal_digit_pigmentation1.90767934
24MP0005253_abnormal_eye_physiology1.86151649
25MP0005645_abnormal_hypothalamus_physiol1.83548487
26MP0001293_anophthalmia1.83137002
27MP0000631_abnormal_neuroendocrine_gland1.70098463
28MP0006292_abnormal_olfactory_placode1.68671648
29MP0001929_abnormal_gametogenesis1.68613460
30MP0009745_abnormal_behavioral_response1.68324033
31MP0002063_abnormal_learning/memory/cond1.68238357
32MP0002572_abnormal_emotion/affect_behav1.66694561
33MP0005187_abnormal_penis_morphology1.61794053
34MP0010094_abnormal_chromosome_stability1.60607111
35MP0002734_abnormal_mechanical_nocicepti1.60423867
36MP0001188_hyperpigmentation1.58767971
37MP0000778_abnormal_nervous_system1.56772107
38MP0001502_abnormal_circadian_rhythm1.56396578
39MP0001486_abnormal_startle_reflex1.55785411
40MP0002095_abnormal_skin_pigmentation1.53484134
41MP0002233_abnormal_nose_morphology1.53203000
42MP0002638_abnormal_pupillary_reflex1.52554536
43MP0002909_abnormal_adrenal_gland1.51881446
44MP0003878_abnormal_ear_physiology1.51753964
45MP0005377_hearing/vestibular/ear_phenot1.51753964
46MP0002272_abnormal_nervous_system1.50616680
47MP0003136_yellow_coat_color1.49124873
48MP0005423_abnormal_somatic_nervous1.47627401
49MP0002064_seizures1.46781476
50MP0005503_abnormal_tendon_morphology1.46542993
51MP0010386_abnormal_urinary_bladder1.45738844
52MP0002557_abnormal_social/conspecific_i1.43231286
53MP0003283_abnormal_digestive_organ1.42405897
54MP0008057_abnormal_DNA_replication1.42066387
55MP0000013_abnormal_adipose_tissue1.41176690
56MP0005171_absent_coat_pigmentation1.39883309
57MP0005379_endocrine/exocrine_gland_phen1.39241678
58MP0001299_abnormal_eye_distance/1.38620301
59MP0009697_abnormal_copulation1.38258460
60MP0001440_abnormal_grooming_behavior1.37984163
61MP0001501_abnormal_sleep_pattern1.35861817
62MP0003950_abnormal_plasma_membrane1.35850281
63MP0000383_abnormal_hair_follicle1.32656393
64MP0002210_abnormal_sex_determination1.32545701
65MP0002928_abnormal_bile_duct1.31524327
66MP0002067_abnormal_sensory_capabilities1.29717239
67MP0002697_abnormal_eye_size1.29350691
68MP0003941_abnormal_skin_development1.29324539
69MP0003718_maternal_effect1.29023602
70MP0000015_abnormal_ear_pigmentation1.27226150
71MP0002282_abnormal_trachea_morphology1.27145866
72MP0003890_abnormal_embryonic-extraembry1.26969683
73MP0005174_abnormal_tail_pigmentation1.26966090
74MP0003755_abnormal_palate_morphology1.22185473
75MP0006276_abnormal_autonomic_nervous1.21011277
76MP0010678_abnormal_skin_adnexa1.20759320
77MP0000566_synostosis1.20307468
78MP0002184_abnormal_innervation1.19892184
79MP0005623_abnormal_meninges_morphology1.18807067
80MP0001944_abnormal_pancreas_morphology1.18205635
81MP0002160_abnormal_reproductive_system1.17466820
82MP0005257_abnormal_intraocular_pressure1.17050798
83MP0004043_abnormal_pH_regulation1.15406932
84MP0001968_abnormal_touch/_nociception1.15243273
85MP0002938_white_spotting1.14890141
86MP0008058_abnormal_DNA_repair1.12543415
87MP0003123_paternal_imprinting1.12356425
88MP0003077_abnormal_cell_cycle1.11810040
89MP0001145_abnormal_male_reproductive1.11422325
90MP0000427_abnormal_hair_cycle1.11377549
91MP0000537_abnormal_urethra_morphology1.10915156
92MP0000371_diluted_coat_color1.10312828
93* MP0002882_abnormal_neuron_morphology1.08791524
94MP0001286_abnormal_eye_development1.08434944
95MP0002092_abnormal_eye_morphology1.06759530
96MP0003935_abnormal_craniofacial_develop1.05952592
97MP0001485_abnormal_pinna_reflex1.05350460
98MP0005394_taste/olfaction_phenotype1.04879754
99MP0005499_abnormal_olfactory_system1.04879754
100MP0004924_abnormal_behavior1.04038168
101MP0005386_behavior/neurological_phenoty1.04038168
102MP0002735_abnormal_chemical_nociception1.02739170
103MP0000534_abnormal_ureter_morphology1.02474032
104MP0000653_abnormal_sex_gland1.02355497
105MP0001346_abnormal_lacrimal_gland1.02046875
106MP0000647_abnormal_sebaceous_gland1.02020078
107MP0003183_abnormal_peptide_metabolism1.01490545
108MP0009250_abnormal_appendicular_skeleto1.00637090
109MP0008932_abnormal_embryonic_tissue1.00543137
110MP0002693_abnormal_pancreas_physiology0.99470312
111MP0005391_vision/eye_phenotype0.98684204
112* MP0002084_abnormal_developmental_patter0.98393401
113* MP0000955_abnormal_spinal_cord0.98312759
114MP0000428_abnormal_craniofacial_morphol0.96234877
115MP0002161_abnormal_fertility/fecundity0.95126377
116MP0003942_abnormal_urinary_system0.94655922
117* MP0002152_abnormal_brain_morphology0.94366895
118MP0000432_abnormal_head_morphology0.94078623
119MP0002177_abnormal_outer_ear0.93613139
120MP0001177_atelectasis0.93051673
121MP0001986_abnormal_taste_sensitivity0.92738178
122MP0003385_abnormal_body_wall0.92602763
123MP0002229_neurodegeneration0.92179667
124MP0005409_darkened_coat_color0.91153151
125MP0010352_gastrointestinal_tract_polyps0.90793808
126MP0005195_abnormal_posterior_eye0.90552621
127MP0002234_abnormal_pharynx_morphology0.90454172
128MP0004134_abnormal_chest_morphology0.90295454
129MP0005197_abnormal_uvea_morphology0.89297039
130MP0003693_abnormal_embryo_hatching0.88182628
131MP0004272_abnormal_basement_membrane0.87807345
132MP0000678_abnormal_parathyroid_gland0.86873930
133MP0004811_abnormal_neuron_physiology0.86785242
134MP0000049_abnormal_middle_ear0.86608122
135MP0002090_abnormal_vision0.86324073
136MP0002752_abnormal_somatic_nervous0.86197335
137MP0001324_abnormal_eye_pigmentation0.85327074
138MP0005395_other_phenotype0.83457629
139* MP0003861_abnormal_nervous_system0.83312073
140MP0008789_abnormal_olfactory_epithelium0.83042650
141MP0002876_abnormal_thyroid_physiology0.82911928
142MP0008569_lethality_at_weaning0.82811794
143MP0003111_abnormal_nucleus_morphology0.82019432
144MP0000026_abnormal_inner_ear0.81474597
145MP0002751_abnormal_autonomic_nervous0.81208127
146MP0005075_abnormal_melanosome_morpholog0.81182538
147MP0001270_distended_abdomen0.81148567
148MP0003937_abnormal_limbs/digits/tail_de0.81030471
149MP0001963_abnormal_hearing_physiology0.80403920
150* MP0002109_abnormal_limb_morphology0.79751915
151* MP0002085_abnormal_embryonic_tissue0.79695062
152MP0003045_fibrosis0.79663294
153MP0001970_abnormal_pain_threshold0.79357574
154MP0002733_abnormal_thermal_nociception0.79000632
155MP0010307_abnormal_tumor_latency0.77410173
156MP0005389_reproductive_system_phenotype0.76873506
157MP0001529_abnormal_vocalization0.76512039
158MP0004957_abnormal_blastocyst_morpholog0.76503075
159MP0004133_heterotaxia0.76499831
160MP0002116_abnormal_craniofacial_bone0.76311136
161MP0000762_abnormal_tongue_morphology0.76072255
162MP0004885_abnormal_endolymph0.75857939
163MP0003119_abnormal_digestive_system0.75652180
164MP0009703_decreased_birth_body0.73423474
165MP0002108_abnormal_muscle_morphology0.72714002
166MP0002075_abnormal_coat/hair_pigmentati0.72352528

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.34897397
2Abnormal respiratory motile cilium physiology (HP:0012261)6.90695993
3Abnormal ciliary motility (HP:0012262)6.41263345
4Absent/shortened dynein arms (HP:0200106)6.24467029
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.24467029
6Rhinitis (HP:0012384)5.53212369
7Abnormal respiratory epithelium morphology (HP:0012253)5.13376516
8Abnormal respiratory motile cilium morphology (HP:0005938)5.13376516
9Chronic bronchitis (HP:0004469)4.58530110
10Medial flaring of the eyebrow (HP:0010747)3.84741882
11Abnormality of midbrain morphology (HP:0002418)3.78637286
12Molar tooth sign on MRI (HP:0002419)3.78637286
13Nephronophthisis (HP:0000090)3.76279771
14Gait imbalance (HP:0002141)3.49439047
15Congenital primary aphakia (HP:0007707)3.48920273
16Tubulointerstitial nephritis (HP:0001970)3.46926161
17Pancreatic fibrosis (HP:0100732)3.41473476
18Chronic hepatic failure (HP:0100626)3.20276126
19True hermaphroditism (HP:0010459)3.17881106
20Bronchiectasis (HP:0002110)3.11712901
21Nephrogenic diabetes insipidus (HP:0009806)3.10129544
22Abnormality of the renal medulla (HP:0100957)3.07755594
23Genital tract atresia (HP:0001827)2.87777570
24Vaginal atresia (HP:0000148)2.77159621
25Infertility (HP:0000789)2.74144181
26Cystic liver disease (HP:0006706)2.61697325
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.56428232
28Hypoplasia of the fovea (HP:0007750)2.56428232
29Poor coordination (HP:0002370)2.55790349
30Aplasia/Hypoplasia of the macula (HP:0008059)2.50821298
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.47783223
32Papillary thyroid carcinoma (HP:0002895)2.45759936
33Occipital encephalocele (HP:0002085)2.41588338
34Abnormality of the fovea (HP:0000493)2.39940845
35Pancreatic cysts (HP:0001737)2.38080059
36Aplasia/Hypoplasia of the lens (HP:0008063)2.36035573
37Abnormal auditory evoked potentials (HP:0006958)2.35014194
38Anencephaly (HP:0002323)2.34150569
39Epileptic encephalopathy (HP:0200134)2.32965911
40Focal motor seizures (HP:0011153)2.32213144
41Aplasia/Hypoplasia affecting the retina (HP:0008061)2.27338609
42Abnormality of the lower motor neuron (HP:0002366)2.21693052
43* Postaxial foot polydactyly (HP:0001830)2.20330339
44* Postaxial hand polydactyly (HP:0001162)2.19420807
45Progressive cerebellar ataxia (HP:0002073)2.16905208
4611 pairs of ribs (HP:0000878)2.16866125
47* Median cleft lip (HP:0000161)2.14091742
48Blue irides (HP:0000635)2.13015837
49Patchy hypopigmentation of hair (HP:0011365)2.10849229
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.09980251
51Sclerocornea (HP:0000647)2.08721209
52Central scotoma (HP:0000603)2.08099606
53White forelock (HP:0002211)2.06990393
54Bronchitis (HP:0012387)2.06635887
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06132590
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05520889
57Tubulointerstitial abnormality (HP:0001969)2.04430675
58Abnormality of chromosome stability (HP:0003220)2.03979815
59Bony spicule pigmentary retinopathy (HP:0007737)2.03285294
60Gastrointestinal atresia (HP:0002589)2.02175785
61Gaze-evoked nystagmus (HP:0000640)1.97043316
62Chromsome breakage (HP:0040012)1.96699111
63Hypopigmentation of the fundus (HP:0007894)1.95450377
64Abnormality of macular pigmentation (HP:0008002)1.94614651
65Oculomotor apraxia (HP:0000657)1.93967428
66* Congenital hepatic fibrosis (HP:0002612)1.93626155
67Aplasia/Hypoplasia of the tibia (HP:0005772)1.92932404
68Decreased central vision (HP:0007663)1.91197006
69Astrocytoma (HP:0009592)1.89630183
70Abnormality of the astrocytes (HP:0100707)1.89630183
71Abnormality of the renal cortex (HP:0011035)1.88548069
72* Fibular hypoplasia (HP:0003038)1.87302928
73Supernumerary spleens (HP:0009799)1.86477615
74Abnormal lung lobation (HP:0002101)1.85984779
75Febrile seizures (HP:0002373)1.85772905
76Absent eyebrow (HP:0002223)1.84931894
77Volvulus (HP:0002580)1.84786458
78Absent frontal sinuses (HP:0002688)1.84414267
79Abnormal drinking behavior (HP:0030082)1.84354878
80Polydipsia (HP:0001959)1.84354878
81Abnormality of ocular smooth pursuit (HP:0000617)1.82339658
82Abnormality of dentin (HP:0010299)1.80602004
83Bell-shaped thorax (HP:0001591)1.79538407
84Specific learning disability (HP:0001328)1.78922131
85Congenital stationary night blindness (HP:0007642)1.77892828
86Atonic seizures (HP:0010819)1.77449518
87Hypoplastic labia majora (HP:0000059)1.76083238
88Meckel diverticulum (HP:0002245)1.75930733
89Anophthalmia (HP:0000528)1.75826093
90Cutaneous finger syndactyly (HP:0010554)1.74703938
91Abnormality of the ileum (HP:0001549)1.74169644
92Impaired smooth pursuit (HP:0007772)1.74137366
93Glioma (HP:0009733)1.73780604
94Nasal polyposis (HP:0100582)1.73362706
95Sloping forehead (HP:0000340)1.73263731
96* Bifid tongue (HP:0010297)1.72522911
97Narrow forehead (HP:0000341)1.71374719
98Truncal obesity (HP:0001956)1.70578651
99Aganglionic megacolon (HP:0002251)1.69565627
100Epileptiform EEG discharges (HP:0011182)1.69475792
101Hyperinsulinemic hypoglycemia (HP:0000825)1.69040612
102Dyschromatopsia (HP:0007641)1.68359364
103Focal seizures (HP:0007359)1.68077703
104Abnormality of the ischium (HP:0003174)1.68076185
105Retinitis pigmentosa (HP:0000510)1.67858306
106Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67073060
107Short tibia (HP:0005736)1.64829002
108* Facial cleft (HP:0002006)1.64717930
109Stage 5 chronic kidney disease (HP:0003774)1.63971757
110Dental crowding (HP:0000678)1.62559389
111Furrowed tongue (HP:0000221)1.62353439
112EEG with generalized epileptiform discharges (HP:0011198)1.61202933
113Widely spaced teeth (HP:0000687)1.59597267
114Genetic anticipation (HP:0003743)1.59496720
115* Preaxial hand polydactyly (HP:0001177)1.58891060
116Male pseudohermaphroditism (HP:0000037)1.58542054
117Type II diabetes mellitus (HP:0005978)1.58477912
118Tubular atrophy (HP:0000092)1.58332919
119Abnormality of the dental root (HP:0006486)1.58110530
120Taurodontia (HP:0000679)1.58110530
121Abnormality of permanent molar morphology (HP:0011071)1.58110530
122Hypothermia (HP:0002045)1.57971935
123Aqueductal stenosis (HP:0002410)1.57448941
124Short foot (HP:0001773)1.56049344
125Intestinal atresia (HP:0011100)1.55896860
126Abnormality of the labia majora (HP:0012881)1.55631356
127Oligodactyly (hands) (HP:0001180)1.55216616
128Broad foot (HP:0001769)1.54438469
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54240941
130Duodenal stenosis (HP:0100867)1.53952351
131Small intestinal stenosis (HP:0012848)1.53952351
132Midline defect of the nose (HP:0004122)1.53950333
133Abnormal rod and cone electroretinograms (HP:0008323)1.53474726
134Prominent nasal bridge (HP:0000426)1.53202349
135Truncal ataxia (HP:0002078)1.53182111
136Menstrual irregularities (HP:0000858)1.52303756
137Abnormality of the dental pulp (HP:0006479)1.52244228
138Preaxial foot polydactyly (HP:0001841)1.52128412
139Recurrent otitis media (HP:0000403)1.52087713
140Decreased circulating renin level (HP:0003351)1.51984050
141Highly arched eyebrow (HP:0002553)1.51662737
142Attenuation of retinal blood vessels (HP:0007843)1.50295029
143Dandy-Walker malformation (HP:0001305)1.50197797
144Astigmatism (HP:0000483)1.50178980
145Multicystic kidney dysplasia (HP:0000003)1.49820724
146Abnormal pancreas size (HP:0012094)1.48934947
147Abnormality of molar (HP:0011077)1.48934911
148Intellectual disability, moderate (HP:0002342)1.48347040
149Holoprosencephaly (HP:0001360)1.48118490
150Hypoplasia of the iris (HP:0007676)1.46422737
151Ectopic kidney (HP:0000086)1.45812077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.66817132
2PDK43.58504499
3PDK33.58504499
4MAPK153.43612412
5PNCK3.35090885
6NTRK33.27009259
7INSRR3.19234716
8WNK32.86239720
9PRKD32.68059099
10TNIK2.56569189
11TTK2.21945536
12FRK2.14599307
13BRSK22.14174660
14CASK2.06572331
15AKT32.03304212
16PDK21.99304931
17MET1.94011855
18STK38L1.92362367
19MAP3K41.77240298
20MAP2K71.72770644
21ACVR1B1.72146279
22PASK1.70458392
23BUB11.70389860
24MST1R1.69691784
25EPHA41.66411695
26ERBB31.56590492
27PBK1.50113967
28CDK31.50031059
29SGK21.48968562
30NTRK21.48278909
31WNK41.46341156
32PRPF4B1.41888427
33PLK41.36257104
34MARK11.35567197
35MAP3K21.31040434
36PLK11.29308549
37BRD41.29103192
38MAPK131.27812583
39WNK11.23418345
40TRIM281.23202845
41GRK11.21831794
42CAMK1G1.17634450
43STK31.16518826
44MKNK11.12644953
45SGK4941.12096799
46SGK2231.12096799
47TSSK61.09417091
48MAP4K21.04378393
49BRSK11.04354169
50CSNK1G11.04330603
51NEK11.03045866
52PLK21.01443073
53CDC71.00780801
54MINK10.98353763
55STK390.96251578
56EPHB20.95358315
57CDC42BPA0.94260262
58PTK2B0.93422838
59EIF2AK10.91597172
60PRKCG0.89375362
61IRAK10.89174460
62SGK30.88986479
63TAF10.86877249
64NEK60.84641534
65CDK120.82492897
66UHMK10.82470654
67MKNK20.81088590
68TGFBR10.81025237
69AURKB0.80697126
70BMPR20.79342571
71MELK0.79307622
72DYRK1A0.78279795
73EIF2AK30.77266977
74ZAK0.76731511
75HIPK20.74677684
76SGK10.74513597
77RPS6KB10.73118480
78MAP3K120.73021634
79CSNK1G30.70674376
80LATS10.70421142
81NUAK10.69312617
82CCNB10.67570935
83SRPK10.67164127
84NEK20.67055149
85NME10.65261644
86CDK50.64540632
87CAMKK20.61254784
88PRKCE0.60988585
89YES10.59119603
90PAK30.59108633
91CDK90.58319184
92PRKCH0.58206564
93BCR0.58106591
94MST40.57809688
95BRAF0.57455698
96VRK10.56456102
97PLK30.56346335
98NLK0.56181957
99ATM0.55712733
100MYLK0.55227998
101CAMK2A0.55164854
102CAMK2B0.55061983
103MARK20.54623289
104STK380.53949049
105ATR0.53146423
106MAP2K40.52581892
107EPHA30.52518920
108NEK90.52214454
109MAPK100.51984067
110OXSR10.50560087
111KSR10.50246912
112EPHA20.49809472
113PRKDC0.49545635
114FGFR20.49348398
115EIF2AK20.49140740
116FGFR10.47694249
117PRKG10.46792196
118AURKA0.46232141
119CAMK1D0.45782178
120RPS6KA20.45777054
121DDR20.45535103
122MAP3K90.45195842
123ERBB40.45165219
124GSK3B0.43556497
125CAMK2D0.43493661
126ERBB20.42994355
127RPS6KA30.42445597
128CSNK1D0.42103430
129CDK70.41701468
130STK240.41563991
131MAPK140.40338692
132IRAK20.39552686
133MAP3K60.38293251
134CHEK10.37372354
135CAMKK10.36503428
136BMPR1B0.35869493
137NTRK10.35505182
138CSNK1G20.35376973
139FER0.34862221
140CHEK20.34560780
141CSNK1E0.34309126
142CDK10.33201905
143PRKCB0.33065322
144PINK10.32835357
145CSNK1A1L0.31687480
146ICK0.30980031
147PRKACA0.30411234
148CAMK10.29721833

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12376309
2Mismatch repair_Homo sapiens_hsa034302.72507379
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.71145147
4Insulin secretion_Homo sapiens_hsa049112.67192656
5Homologous recombination_Homo sapiens_hsa034402.61003650
6Phototransduction_Homo sapiens_hsa047442.54037625
7Amphetamine addiction_Homo sapiens_hsa050312.39663496
8Circadian entrainment_Homo sapiens_hsa047132.38108392
9GABAergic synapse_Homo sapiens_hsa047272.20817705
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16020957
11Synaptic vesicle cycle_Homo sapiens_hsa047212.14189246
12Morphine addiction_Homo sapiens_hsa050322.13710621
13Taste transduction_Homo sapiens_hsa047422.12602348
14Olfactory transduction_Homo sapiens_hsa047402.09752014
15Long-term potentiation_Homo sapiens_hsa047202.06516460
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95734046
17Glutamatergic synapse_Homo sapiens_hsa047241.94116572
18Cocaine addiction_Homo sapiens_hsa050301.85592547
19Protein export_Homo sapiens_hsa030601.85548052
20Dopaminergic synapse_Homo sapiens_hsa047281.83294244
21Cell cycle_Homo sapiens_hsa041101.83279633
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82291751
23Nucleotide excision repair_Homo sapiens_hsa034201.75209946
24Renin secretion_Homo sapiens_hsa049241.74263077
25Propanoate metabolism_Homo sapiens_hsa006401.63703184
26Serotonergic synapse_Homo sapiens_hsa047261.62578300
27DNA replication_Homo sapiens_hsa030301.62192057
28Hippo signaling pathway_Homo sapiens_hsa043901.62087454
29Circadian rhythm_Homo sapiens_hsa047101.60824161
30Dorso-ventral axis formation_Homo sapiens_hsa043201.50210154
31Type II diabetes mellitus_Homo sapiens_hsa049301.45749894
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44193788
33TGF-beta signaling pathway_Homo sapiens_hsa043501.42385833
34Cholinergic synapse_Homo sapiens_hsa047251.42083869
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38980408
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35743470
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35735661
38Calcium signaling pathway_Homo sapiens_hsa040201.33913003
39Glucagon signaling pathway_Homo sapiens_hsa049221.32718934
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32707528
41Salivary secretion_Homo sapiens_hsa049701.30918306
42Vibrio cholerae infection_Homo sapiens_hsa051101.30861901
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30853992
44Alcoholism_Homo sapiens_hsa050341.30041522
45Adherens junction_Homo sapiens_hsa045201.27434882
46Collecting duct acid secretion_Homo sapiens_hsa049661.26085529
47* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24766032
48Proteasome_Homo sapiens_hsa030501.23774420
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23394076
50One carbon pool by folate_Homo sapiens_hsa006701.23355546
51Gastric acid secretion_Homo sapiens_hsa049711.20293543
52Tyrosine metabolism_Homo sapiens_hsa003501.19929325
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19540143
54Long-term depression_Homo sapiens_hsa047301.19493061
55cAMP signaling pathway_Homo sapiens_hsa040241.19150231
56RNA transport_Homo sapiens_hsa030131.19046611
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18753889
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13291586
59Estrogen signaling pathway_Homo sapiens_hsa049151.12117325
60Oxytocin signaling pathway_Homo sapiens_hsa049211.10861687
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10382709
62Tight junction_Homo sapiens_hsa045301.09718766
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07044962
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06180623
65Thyroid hormone synthesis_Homo sapiens_hsa049181.05056107
66p53 signaling pathway_Homo sapiens_hsa041151.04737884
67ECM-receptor interaction_Homo sapiens_hsa045121.04264324
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00261454
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00199687
70Oocyte meiosis_Homo sapiens_hsa041140.98524936
71Chemical carcinogenesis_Homo sapiens_hsa052040.98335964
72Fanconi anemia pathway_Homo sapiens_hsa034600.98285646
73Glutathione metabolism_Homo sapiens_hsa004800.97726495
74Wnt signaling pathway_Homo sapiens_hsa043100.97561740
75Hedgehog signaling pathway_Homo sapiens_hsa043400.94522583
76beta-Alanine metabolism_Homo sapiens_hsa004100.93960467
77Melanogenesis_Homo sapiens_hsa049160.93887903
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93719448
79Base excision repair_Homo sapiens_hsa034100.93504464
80RNA polymerase_Homo sapiens_hsa030200.93343997
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.92554382
82Folate biosynthesis_Homo sapiens_hsa007900.91551227
83Axon guidance_Homo sapiens_hsa043600.91104685
84Oxidative phosphorylation_Homo sapiens_hsa001900.89546595
85Histidine metabolism_Homo sapiens_hsa003400.88831379
86Basal transcription factors_Homo sapiens_hsa030220.88175602
87mRNA surveillance pathway_Homo sapiens_hsa030150.88008338
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87831176
89Inositol phosphate metabolism_Homo sapiens_hsa005620.87646017
90Type I diabetes mellitus_Homo sapiens_hsa049400.85839955
91GnRH signaling pathway_Homo sapiens_hsa049120.85762991
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85666674
93Fatty acid elongation_Homo sapiens_hsa000620.84536921
94Gap junction_Homo sapiens_hsa045400.81756924
95Pancreatic secretion_Homo sapiens_hsa049720.78844289
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77507663
97Pyruvate metabolism_Homo sapiens_hsa006200.77418183
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.77403859
99Vitamin B6 metabolism_Homo sapiens_hsa007500.76474446
100Selenocompound metabolism_Homo sapiens_hsa004500.75939666
101Butanoate metabolism_Homo sapiens_hsa006500.74707878
102Steroid biosynthesis_Homo sapiens_hsa001000.73733808
103Parkinsons disease_Homo sapiens_hsa050120.70872706
104Melanoma_Homo sapiens_hsa052180.70010538
105N-Glycan biosynthesis_Homo sapiens_hsa005100.69434477
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69139585
107Ovarian steroidogenesis_Homo sapiens_hsa049130.67674569
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67541919
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66154007
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64184082
111MAPK signaling pathway_Homo sapiens_hsa040100.63674110
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62463267
113Small cell lung cancer_Homo sapiens_hsa052220.62226288
114Huntingtons disease_Homo sapiens_hsa050160.62022171
115Basal cell carcinoma_Homo sapiens_hsa052170.61955505
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60048076
117ErbB signaling pathway_Homo sapiens_hsa040120.59171619
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57813420
119Alzheimers disease_Homo sapiens_hsa050100.56622276
120Pyrimidine metabolism_Homo sapiens_hsa002400.56502893
121Glioma_Homo sapiens_hsa052140.56226980
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56129953
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55888390
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.55734675
125Pathways in cancer_Homo sapiens_hsa052000.55162921
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55113829
127Peroxisome_Homo sapiens_hsa041460.55074357
128Sulfur metabolism_Homo sapiens_hsa009200.51726218
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50997617
130MicroRNAs in cancer_Homo sapiens_hsa052060.50855575
131Sphingolipid metabolism_Homo sapiens_hsa006000.50555370
132Metabolic pathways_Homo sapiens_hsa011000.49558634
133Caffeine metabolism_Homo sapiens_hsa002320.48996077
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48722267
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47623415
136Nitrogen metabolism_Homo sapiens_hsa009100.46906391
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46793648
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46646800
139Prostate cancer_Homo sapiens_hsa052150.46414950
140Fatty acid metabolism_Homo sapiens_hsa012120.46163068
141Spliceosome_Homo sapiens_hsa030400.45693060
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45590178
143Dilated cardiomyopathy_Homo sapiens_hsa054140.45229011
144Fatty acid degradation_Homo sapiens_hsa000710.45183172
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44194422
146Protein digestion and absorption_Homo sapiens_hsa049740.43371000
147Lysine degradation_Homo sapiens_hsa003100.42300669
148Ras signaling pathway_Homo sapiens_hsa040140.41865399
149Non-homologous end-joining_Homo sapiens_hsa034500.41269120
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40874574
151Tryptophan metabolism_Homo sapiens_hsa003800.40773518
152Cardiac muscle contraction_Homo sapiens_hsa042600.39916053
153Endometrial cancer_Homo sapiens_hsa052130.39503115
154Retinol metabolism_Homo sapiens_hsa008300.39045281
155Phenylalanine metabolism_Homo sapiens_hsa003600.39005076
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38801112
157Purine metabolism_Homo sapiens_hsa002300.37709353
158Choline metabolism in cancer_Homo sapiens_hsa052310.37003666
159RNA degradation_Homo sapiens_hsa030180.36720290
160ABC transporters_Homo sapiens_hsa020100.36151283
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35692460
162Regulation of autophagy_Homo sapiens_hsa041400.35378081
163Systemic lupus erythematosus_Homo sapiens_hsa053220.35128525
164Mineral absorption_Homo sapiens_hsa049780.32976815
165Insulin signaling pathway_Homo sapiens_hsa049100.30007596

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