DYNC2LI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intraciliary transport (GO:0042073)5.47326013
2axoneme assembly (GO:0035082)5.39944189
3cilium movement (GO:0003341)4.99280412
4protein localization to cilium (GO:0061512)4.36817806
5axonemal dynein complex assembly (GO:0070286)4.04306430
6cilium or flagellum-dependent cell motility (GO:0001539)3.99944253
7regulation of cilium movement (GO:0003352)3.95175405
8behavioral response to nicotine (GO:0035095)3.87338299
9COPI coating of Golgi vesicle (GO:0048205)3.85586045
10Golgi transport vesicle coating (GO:0048200)3.85586045
11motile cilium assembly (GO:0044458)3.63335202
12epithelial cilium movement (GO:0003351)3.63012880
13adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.61277608
14GTP biosynthetic process (GO:0006183)3.40253387
15cilium morphogenesis (GO:0060271)3.35287764
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32973404
17sensory perception of smell (GO:0007608)3.24525351
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24087033
19protein complex biogenesis (GO:0070271)3.23928487
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16396176
21ATP synthesis coupled proton transport (GO:0015986)3.16396176
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14109922
23detection of calcium ion (GO:0005513)3.13741114
24response to pheromone (GO:0019236)3.10916425
25guanosine-containing compound biosynthetic process (GO:1901070)3.05520379
26respiratory chain complex IV assembly (GO:0008535)3.04053339
27protein maturation by protein folding (GO:0022417)3.02226570
28postsynaptic membrane organization (GO:0001941)2.99824439
29protein polyglutamylation (GO:0018095)2.99817897
30neuron cell-cell adhesion (GO:0007158)2.98449660
31synaptic vesicle exocytosis (GO:0016079)2.97232480
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97040059
33mitochondrial respiratory chain complex I assembly (GO:0032981)2.97040059
34NADH dehydrogenase complex assembly (GO:0010257)2.97040059
35positive regulation of vesicle fusion (GO:0031340)2.96873102
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94671757
37platelet dense granule organization (GO:0060155)2.93812161
38mitochondrial respiratory chain complex assembly (GO:0033108)2.91567926
39regulation of microtubule-based movement (GO:0060632)2.91492860
40ER overload response (GO:0006983)2.90989795
41* cilium assembly (GO:0042384)2.90037538
42* cilium organization (GO:0044782)2.89630437
43protein neddylation (GO:0045116)2.88579042
44cellular ketone body metabolic process (GO:0046950)2.86999981
45innervation (GO:0060384)2.85751917
46regulation of synaptic vesicle exocytosis (GO:2000300)2.83587211
47UTP biosynthetic process (GO:0006228)2.81423722
48regulation of glucokinase activity (GO:0033131)2.81098811
49regulation of hexokinase activity (GO:1903299)2.81098811
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79215155
51cullin deneddylation (GO:0010388)2.79082055
52centriole replication (GO:0007099)2.78674155
53melanosome transport (GO:0032402)2.77974405
54neural tube formation (GO:0001841)2.77840645
55presynaptic membrane assembly (GO:0097105)2.74843366
56L-fucose metabolic process (GO:0042354)2.73802568
57L-fucose catabolic process (GO:0042355)2.73802568
58fucose catabolic process (GO:0019317)2.73802568
59nucleoside diphosphate phosphorylation (GO:0006165)2.73533767
60water-soluble vitamin biosynthetic process (GO:0042364)2.73361541
61retinal cone cell development (GO:0046549)2.73181397
62synaptic vesicle docking involved in exocytosis (GO:0016081)2.72103293
63electron transport chain (GO:0022900)2.69615556
64nonmotile primary cilium assembly (GO:0035058)2.69508122
65positive regulation of mitochondrial fission (GO:0090141)2.69068096
66cytochrome complex assembly (GO:0017004)2.67912611
67female mating behavior (GO:0060180)2.67786478
68preassembly of GPI anchor in ER membrane (GO:0016254)2.67773231
69glutamate secretion (GO:0014047)2.67493960
70GPI anchor metabolic process (GO:0006505)2.67486597
71left/right pattern formation (GO:0060972)2.66783151
72sensory perception of chemical stimulus (GO:0007606)2.64908387
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.64571313
74photoreceptor cell maintenance (GO:0045494)2.64525790
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.64420948
76urinary tract smooth muscle contraction (GO:0014848)2.61506983
77pigment granule transport (GO:0051904)2.61503585
78respiratory electron transport chain (GO:0022904)2.60537047
79detection of light stimulus involved in sensory perception (GO:0050962)2.57405170
80detection of light stimulus involved in visual perception (GO:0050908)2.57405170
81ketone body metabolic process (GO:1902224)2.57338276
82establishment of melanosome localization (GO:0032401)2.56895485
83retinal rod cell development (GO:0046548)2.56642660
84regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.55773673
85regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.55773673
86negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55576737
87regulation of vesicle fusion (GO:0031338)2.55278946
88membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54890045
89long-term synaptic potentiation (GO:0060291)2.54693754
90retinal ganglion cell axon guidance (GO:0031290)2.53643456
91protein deneddylation (GO:0000338)2.51991088
92presynaptic membrane organization (GO:0097090)2.51841643
93cornea development in camera-type eye (GO:0061303)2.51214649
94lactate metabolic process (GO:0006089)2.50792697
95mannosylation (GO:0097502)2.50610087
96photoreceptor cell development (GO:0042461)2.50227945
97limb bud formation (GO:0060174)2.49807803
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49479042
99negative regulation of translation, ncRNA-mediated (GO:0040033)2.49479042
100regulation of translation, ncRNA-mediated (GO:0045974)2.49479042
101protein retention in ER lumen (GO:0006621)2.48616550
102centriole assembly (GO:0098534)2.46976900
103smoothened signaling pathway (GO:0007224)2.45541193
104UTP metabolic process (GO:0046051)2.45230351
105nephron epithelium morphogenesis (GO:0072088)2.43759427
106nephron tubule morphogenesis (GO:0072078)2.43759427
107calcium-mediated signaling using intracellular calcium source (GO:0035584)2.43375997
108dopamine biosynthetic process (GO:0042416)2.42953114
109replication fork processing (GO:0031297)2.42632683
110kidney morphogenesis (GO:0060993)2.42520115
111establishment of pigment granule localization (GO:0051905)2.42131472
112neuron fate determination (GO:0048664)2.40996814
113negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.40245504
114insulin secretion (GO:0030073)2.39503157
115transmission of nerve impulse (GO:0019226)2.39071612
116protein-cofactor linkage (GO:0018065)2.38135897
117spinal cord motor neuron differentiation (GO:0021522)2.37489800
118regulation of synaptic vesicle transport (GO:1902803)2.37302284
119* determination of left/right symmetry (GO:0007368)2.36706847
120pyrimidine nucleobase catabolic process (GO:0006208)2.36559062
121melanosome localization (GO:0032400)2.34458498
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.33812596
123CTP metabolic process (GO:0046036)2.33655538
124CTP biosynthetic process (GO:0006241)2.33655538
125ATP hydrolysis coupled proton transport (GO:0015991)2.33637276
126energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.33637276
127somite development (GO:0061053)2.32886259
128GPI anchor biosynthetic process (GO:0006506)2.32827460
129synaptic transmission, dopaminergic (GO:0001963)2.31443780
130extracellular negative regulation of signal transduction (GO:1900116)2.31242826
131extracellular regulation of signal transduction (GO:1900115)2.31242826
132ventricular system development (GO:0021591)2.31079765
133cochlea development (GO:0090102)2.30930905
134limb development (GO:0060173)2.30812231
135appendage development (GO:0048736)2.30812231
136regulation of short-term neuronal synaptic plasticity (GO:0048172)2.30366139
137membrane repolarization during action potential (GO:0086011)2.29388129
138aminoglycoside antibiotic metabolic process (GO:0030647)2.29109194
139piRNA metabolic process (GO:0034587)2.29068829
140gamma-aminobutyric acid transport (GO:0015812)2.28831000
141inner ear receptor stereocilium organization (GO:0060122)2.28456286
142sperm motility (GO:0030317)2.27954505
143negative regulation of cation channel activity (GO:2001258)2.27945139
144resolution of meiotic recombination intermediates (GO:0000712)2.27900279
145positive regulation of gastrulation (GO:2000543)2.27883594
146neuron fate specification (GO:0048665)2.27396257
147ganglion development (GO:0061548)2.26774081
148nucleobase catabolic process (GO:0046113)2.26447514
149aldehyde catabolic process (GO:0046185)2.26441088
150somite rostral/caudal axis specification (GO:0032525)2.25715876
151* determination of bilateral symmetry (GO:0009855)2.25569795
152protein localization to synapse (GO:0035418)2.24787263
153regulation of glutamate receptor signaling pathway (GO:1900449)2.24736745
154behavioral response to ethanol (GO:0048149)2.24599923
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.24190434
156microtubule bundle formation (GO:0001578)2.24157965
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.23924075
158eye photoreceptor cell development (GO:0042462)2.23789431
159daunorubicin metabolic process (GO:0044597)2.23643963
160polyketide metabolic process (GO:0030638)2.23643963
161doxorubicin metabolic process (GO:0044598)2.23643963
162microtubule-based transport (GO:0010970)2.21905458
163pigment granule localization (GO:0051875)2.21859694
164RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.21537937
165tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.21537937
166positive regulation of meiosis (GO:0045836)2.21449664
167negative regulation of microtubule polymerization (GO:0031115)2.21351242
168striatum development (GO:0021756)2.21011332
169anterograde synaptic vesicle transport (GO:0048490)2.20801369
170proton transport (GO:0015992)2.20309366
171regulation of female receptivity (GO:0045924)2.20134695
172negative regulation of sodium ion transport (GO:0010766)2.19987768
173signal peptide processing (GO:0006465)2.19957711
174* cellular component assembly involved in morphogenesis (GO:0010927)2.18817177
175left/right axis specification (GO:0070986)2.18361023
176response to misfolded protein (GO:0051788)2.17748640
177vocalization behavior (GO:0071625)2.17175482
178transferrin transport (GO:0033572)2.17074776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85083668
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.55664022
3GBX2_23144817_ChIP-Seq_PC3_Human2.92118749
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48637116
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39687424
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37680244
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37385050
8IGF1R_20145208_ChIP-Seq_DFB_Human2.33196370
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.32039126
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.26998230
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26907155
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.17801465
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.16038150
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16037009
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13470987
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11270353
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11035560
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03271631
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94738685
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.94214272
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93664978
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93300553
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92998669
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92998669
25RNF2_27304074_Chip-Seq_NSC_Mouse1.91958244
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90182509
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87289292
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86904129
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85617149
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84097169
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81682410
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.81491558
33REST_21632747_ChIP-Seq_MESCs_Mouse1.80324103
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.79642958
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76631785
36P300_19829295_ChIP-Seq_ESCs_Human1.71433402
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70140264
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.67667107
39ER_23166858_ChIP-Seq_MCF-7_Human1.63531900
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63210245
41SMAD4_21799915_ChIP-Seq_A2780_Human1.61547256
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61218897
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60541361
44TAF15_26573619_Chip-Seq_HEK293_Human1.59002647
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.58460895
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.57165481
47* ELK1_19687146_ChIP-ChIP_HELA_Human1.55750145
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50488591
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49967228
50* FUS_26573619_Chip-Seq_HEK293_Human1.47822293
51ZNF274_21170338_ChIP-Seq_K562_Hela1.46538261
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45421609
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44719178
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44650345
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.43132024
56EWS_26573619_Chip-Seq_HEK293_Human1.39862539
57MYC_18940864_ChIP-ChIP_HL60_Human1.38286084
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35860418
59NANOG_19829295_ChIP-Seq_ESCs_Human1.34347647
60SOX2_19829295_ChIP-Seq_ESCs_Human1.34347647
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34154321
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33779467
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32847693
64TP53_22573176_ChIP-Seq_HFKS_Human1.31371509
65VDR_22108803_ChIP-Seq_LS180_Human1.29993872
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29421672
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.29054616
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28275875
69* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27997853
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.27647590
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27334457
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.27264700
73TCF4_23295773_ChIP-Seq_U87_Human1.26943757
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26455494
75BCAT_22108803_ChIP-Seq_LS180_Human1.26092532
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.24808001
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23314994
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22314573
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.22304259
80TP53_18474530_ChIP-ChIP_U2OS_Human1.22101625
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19992659
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16857324
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16229084
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15047169
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15047169
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.14952223
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14952223
88* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14064177
89VDR_23849224_ChIP-Seq_CD4+_Human1.12477794
90P53_22387025_ChIP-Seq_ESCs_Mouse1.11779426
91AR_25329375_ChIP-Seq_VCAP_Human1.11686834
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11124561
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11080490
94IRF1_19129219_ChIP-ChIP_H3396_Human1.10769954
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.10334807
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09726885
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09387149
98JUN_21703547_ChIP-Seq_K562_Human1.08720242
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08132410
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.07866083
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07671072
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.07656207
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.07341823
104DROSHA_22980978_ChIP-Seq_HELA_Human1.07322582
105STAT3_23295773_ChIP-Seq_U87_Human1.06176530
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05901482
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05888948
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05565501
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04771019
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04161429
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.04060542
112AR_20517297_ChIP-Seq_VCAP_Human1.03579440
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03253942
114* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02962259
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01335595
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.01319751
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.01109716
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01077807
119SMAD3_21741376_ChIP-Seq_ESCs_Human1.01029035
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00737315
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.99910590
122RUNX2_22187159_ChIP-Seq_PCA_Human0.99761340
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.99750395
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99218458
125* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99008289
126* NCOR_22424771_ChIP-Seq_293T_Human0.98313330
127HTT_18923047_ChIP-ChIP_STHdh_Human0.98173197
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97987289
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97558681
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96552509
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96216683
132CBP_20019798_ChIP-Seq_JUKART_Human0.96216683
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94640392
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94219925
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.94038210
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.93627403
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93558792
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91766972
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91259199
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91059033
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90663822
142AHR_22903824_ChIP-Seq_MCF-7_Human0.90248851
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89910516
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89850404
145* WT1_19549856_ChIP-ChIP_CCG9911_Human0.89203910
146POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.89080852
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88744686
148TCF4_22108803_ChIP-Seq_LS180_Human0.88511883
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88426722
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88152129
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87261471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.20989495
2MP0001984_abnormal_olfaction2.95388744
3MP0003136_yellow_coat_color2.55469413
4MP0005645_abnormal_hypothalamus_physiol2.54541945
5MP0003183_abnormal_peptide_metabolism2.40795042
6MP0010386_abnormal_urinary_bladder2.32448244
7MP0002653_abnormal_ependyma_morphology2.27593783
8MP0003880_abnormal_central_pattern2.27541868
9MP0000013_abnormal_adipose_tissue2.25759166
10MP0004859_abnormal_synaptic_plasticity2.17441341
11MP0005646_abnormal_pituitary_gland2.17347251
12MP0004043_abnormal_pH_regulation2.15040538
13MP0002909_abnormal_adrenal_gland2.11682689
14MP0003635_abnormal_synaptic_transmissio1.94261616
15MP0006072_abnormal_retinal_apoptosis1.94022457
16MP0003195_calcinosis1.89922517
17MP0003011_delayed_dark_adaptation1.88650426
18MP0002638_abnormal_pupillary_reflex1.86824912
19MP0003283_abnormal_digestive_organ1.85333480
20MP0001968_abnormal_touch/_nociception1.80990222
21MP0008789_abnormal_olfactory_epithelium1.80897547
22MP0002734_abnormal_mechanical_nocicepti1.79724079
23MP0008875_abnormal_xenobiotic_pharmacok1.76264150
24MP0001986_abnormal_taste_sensitivity1.73637775
25MP0009780_abnormal_chondrocyte_physiolo1.71436995
26MP0002063_abnormal_learning/memory/cond1.71108157
27MP0002837_dystrophic_cardiac_calcinosis1.69736686
28MP0000678_abnormal_parathyroid_gland1.69405717
29MP0004270_analgesia1.67354960
30MP0004858_abnormal_nervous_system1.59316235
31MP0000631_abnormal_neuroendocrine_gland1.58988859
32MP0006276_abnormal_autonomic_nervous1.58700371
33MP0000049_abnormal_middle_ear1.58320607
34MP0002572_abnormal_emotion/affect_behav1.58264648
35MP0003121_genomic_imprinting1.57661186
36MP0002184_abnormal_innervation1.57523241
37MP0005394_taste/olfaction_phenotype1.54957748
38MP0005499_abnormal_olfactory_system1.54957748
39MP0010030_abnormal_orbit_morphology1.54730984
40MP0005084_abnormal_gallbladder_morpholo1.54548353
41MP0000566_synostosis1.52920173
42MP0002272_abnormal_nervous_system1.51255989
43MP0002736_abnormal_nociception_after1.50924026
44MP0009745_abnormal_behavioral_response1.49044307
45MP0003123_paternal_imprinting1.48760051
46MP0004142_abnormal_muscle_tone1.47688329
47MP0002733_abnormal_thermal_nociception1.46923320
48MP0002735_abnormal_chemical_nociception1.42594673
49MP0000569_abnormal_digit_pigmentation1.41972675
50MP0002163_abnormal_gland_morphology1.40370051
51MP0000778_abnormal_nervous_system1.40150056
52MP0002557_abnormal_social/conspecific_i1.39872307
53MP0001293_anophthalmia1.39202660
54MP0002102_abnormal_ear_morphology1.38608919
55MP0004133_heterotaxia1.38347462
56MP0003942_abnormal_urinary_system1.36909913
57MP0002064_seizures1.36757063
58MP0002876_abnormal_thyroid_physiology1.34713213
59MP0003787_abnormal_imprinting1.33024499
60MP0001440_abnormal_grooming_behavior1.32142282
61MP0002067_abnormal_sensory_capabilities1.28497231
62MP0002234_abnormal_pharynx_morphology1.28250584
63MP0001944_abnormal_pancreas_morphology1.27751429
64MP0003890_abnormal_embryonic-extraembry1.27715317
65MP0005379_endocrine/exocrine_gland_phen1.26629575
66MP0001970_abnormal_pain_threshold1.25049726
67MP0008995_early_reproductive_senescence1.24912818
68MP0004147_increased_porphyrin_level1.24789273
69MP0008058_abnormal_DNA_repair1.22819462
70MP0002877_abnormal_melanocyte_morpholog1.21841996
71MP0001188_hyperpigmentation1.21077424
72MP0004885_abnormal_endolymph1.20705872
73MP0000427_abnormal_hair_cycle1.20251248
74MP0005423_abnormal_somatic_nervous1.20124371
75MP0008872_abnormal_physiological_respon1.19227901
76MP0002751_abnormal_autonomic_nervous1.18524653
77MP0000383_abnormal_hair_follicle1.17625148
78MP0002938_white_spotting1.17507957
79MP0001905_abnormal_dopamine_level1.16670311
80MP0001501_abnormal_sleep_pattern1.15377395
81MP0003937_abnormal_limbs/digits/tail_de1.13992245
82MP0003718_maternal_effect1.13311517
83MP0009046_muscle_twitch1.10914707
84MP0001485_abnormal_pinna_reflex1.10762460
85MP0001502_abnormal_circadian_rhythm1.09966122
86MP0005195_abnormal_posterior_eye1.09965866
87MP0001486_abnormal_startle_reflex1.08522708
88MP0000026_abnormal_inner_ear1.08040103
89MP0009379_abnormal_foot_pigmentation1.04796383
90MP0001324_abnormal_eye_pigmentation1.04406299
91MP0005391_vision/eye_phenotype1.04136805
92MP0005389_reproductive_system_phenotype1.04099157
93MP0005174_abnormal_tail_pigmentation1.03534359
94MP0002882_abnormal_neuron_morphology1.02681683
95MP0002295_abnormal_pulmonary_circulatio1.01882810
96MP0002928_abnormal_bile_duct1.01709628
97MP0000534_abnormal_ureter_morphology1.00704370
98MP0001664_abnormal_digestion1.00274275
99MP0003879_abnormal_hair_cell1.00075526
100MP0006292_abnormal_olfactory_placode0.99243089
101MP0001529_abnormal_vocalization0.99135577
102MP0002095_abnormal_skin_pigmentation0.97709446
103MP0005623_abnormal_meninges_morphology0.95890031
104MP0008877_abnormal_DNA_methylation0.95609589
105MP0005220_abnormal_exocrine_pancreas0.94979635
106MP0004215_abnormal_myocardial_fiber0.94863349
107MP0000955_abnormal_spinal_cord0.94848982
108MP0001270_distended_abdomen0.94631922
109MP0005551_abnormal_eye_electrophysiolog0.94022617
110MP0000647_abnormal_sebaceous_gland0.93860194
111MP0002233_abnormal_nose_morphology0.93269489
112MP0005367_renal/urinary_system_phenotyp0.93158048
113MP0000516_abnormal_urinary_system0.93158048
114MP0000537_abnormal_urethra_morphology0.91978900
115MP0005386_behavior/neurological_phenoty0.90637397
116MP0004924_abnormal_behavior0.90637397
117MP0002282_abnormal_trachea_morphology0.90142114
118MP0005503_abnormal_tendon_morphology0.88756286
119MP0005187_abnormal_penis_morphology0.87944015
120MP0002160_abnormal_reproductive_system0.87108821
121MP0005332_abnormal_amino_acid0.85246602
122MP0004233_abnormal_muscle_weight0.84812273
123MP0005253_abnormal_eye_physiology0.84706110
124MP0001299_abnormal_eye_distance/0.83683657
125MP0002277_abnormal_respiratory_mucosa0.83113836
126MP0003698_abnormal_male_reproductive0.83014289
127MP0002116_abnormal_craniofacial_bone0.82177929
128MP0001963_abnormal_hearing_physiology0.81878244
129MP0001929_abnormal_gametogenesis0.81875365
130MP0002752_abnormal_somatic_nervous0.81316874
131* MP0002152_abnormal_brain_morphology0.81144372
132MP0001177_atelectasis0.80903999
133MP0000538_abnormal_urinary_bladder0.80381263
134MP0000003_abnormal_adipose_tissue0.79733883
135MP0002896_abnormal_bone_mineralization0.79109537
136MP0000372_irregular_coat_pigmentation0.77302608
137MP0004811_abnormal_neuron_physiology0.77220715
138MP0002177_abnormal_outer_ear0.76728456
139MP0001765_abnormal_ion_homeostasis0.76453398

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.78160721
2Abnormal respiratory motile cilium physiology (HP:0012261)5.31308773
3Rhinitis (HP:0012384)4.65503712
4Abnormal respiratory epithelium morphology (HP:0012253)4.55718304
5Abnormal respiratory motile cilium morphology (HP:0005938)4.55718304
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.07807965
7Medial flaring of the eyebrow (HP:0010747)3.89043883
8Gait imbalance (HP:0002141)3.79311966
9Congenital primary aphakia (HP:0007707)3.72954530
10Nephrogenic diabetes insipidus (HP:0009806)3.56636547
11Chronic bronchitis (HP:0004469)3.40840887
12Hypothermia (HP:0002045)3.31445268
13Pancreatic fibrosis (HP:0100732)3.27856518
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.23708342
15True hermaphroditism (HP:0010459)3.23265646
16Median cleft lip (HP:0000161)3.22705355
17Hyperactive renin-angiotensin system (HP:0000841)3.21958668
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.14170775
19Absent/shortened dynein arms (HP:0200106)3.14170775
20Abnormality of midbrain morphology (HP:0002418)3.11026711
21Molar tooth sign on MRI (HP:0002419)3.11026711
22Genital tract atresia (HP:0001827)3.10492138
23Vaginal atresia (HP:0000148)2.99782140
24Bifid tongue (HP:0010297)2.99275193
25Chronic hepatic failure (HP:0100626)2.95291414
26Abnormality of dentin (HP:0010299)2.87921726
27Abnormality of the renal cortex (HP:0011035)2.87385985
28Aplasia/Hypoplasia of the lens (HP:0008063)2.72603376
29Nephronophthisis (HP:0000090)2.72223472
30Anencephaly (HP:0002323)2.72071089
31Sclerocornea (HP:0000647)2.69001970
32Poor coordination (HP:0002370)2.64185239
33Type II lissencephaly (HP:0007260)2.58446865
34Decreased circulating renin level (HP:0003351)2.53516527
35Acute necrotizing encephalopathy (HP:0006965)2.48411193
36Bronchiectasis (HP:0002110)2.48408184
37Pancreatic cysts (HP:0001737)2.43935486
38Increased circulating renin level (HP:0000848)2.43866730
39Tubular atrophy (HP:0000092)2.42008913
40Abnormality of the renal medulla (HP:0100957)2.35142420
41Congenital stationary night blindness (HP:0007642)2.34943903
42Male pseudohermaphroditism (HP:0000037)2.34918404
43Focal motor seizures (HP:0011153)2.34880205
44Furrowed tongue (HP:0000221)2.33418784
45Visual hallucinations (HP:0002367)2.31796661
46Abnormality of calcium-phosphate metabolism (HP:0100530)2.31715599
47Abnormal mitochondria in muscle tissue (HP:0008316)2.31164169
48Polydipsia (HP:0001959)2.29435149
49Abnormal drinking behavior (HP:0030082)2.29435149
50Postaxial hand polydactyly (HP:0001162)2.28554564
51Abnormality of renin-angiotensin system (HP:0000847)2.26888112
52Abolished electroretinogram (ERG) (HP:0000550)2.18721810
53Increased hepatocellular lipid droplets (HP:0006565)2.17656807
54Hyperaldosteronism (HP:0000859)2.17161175
55Increased CSF lactate (HP:0002490)2.16948740
56Renal cortical cysts (HP:0000803)2.16773278
57Occipital encephalocele (HP:0002085)2.16715765
58Broad foot (HP:0001769)2.16341768
59Facial cleft (HP:0002006)2.13912531
60Cystic liver disease (HP:0006706)2.13797327
61Atonic seizures (HP:0010819)2.13171860
62Methylmalonic acidemia (HP:0002912)2.12383821
63Lipid accumulation in hepatocytes (HP:0006561)2.11638221
64Hypokalemia (HP:0002900)2.10032175
65Hyperglycinemia (HP:0002154)2.09662265
663-Methylglutaconic aciduria (HP:0003535)2.09533521
67Megalencephaly (HP:0001355)2.07530029
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.05490993
69Epileptic encephalopathy (HP:0200134)2.04790857
70Hypomagnesemia (HP:0002917)2.04261949
71Progressive macrocephaly (HP:0004481)2.03109124
72Abnormality of the labia minora (HP:0012880)2.01453755
73Abnormality of magnesium homeostasis (HP:0004921)2.00118987
74Renal salt wasting (HP:0000127)2.00049056
75Postaxial foot polydactyly (HP:0001830)1.99522753
76Specific learning disability (HP:0001328)1.99068490
77Congenital, generalized hypertrichosis (HP:0004540)1.97415366
78Limb dystonia (HP:0002451)1.97057898
79Abnormal biliary tract physiology (HP:0012439)1.96334275
80Bile duct proliferation (HP:0001408)1.96334275
81Polyuria (HP:0000103)1.95348939
82Abnormal rod and cone electroretinograms (HP:0008323)1.94346120
83Oculomotor apraxia (HP:0000657)1.92896678
84Hypokalemic alkalosis (HP:0001949)1.92700882
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.92585792
86Preaxial hand polydactyly (HP:0001177)1.90425402
87Hyperventilation (HP:0002883)1.89256776
88Agitation (HP:0000713)1.89249824
89Cerebellar dysplasia (HP:0007033)1.88845585
90Anophthalmia (HP:0000528)1.88505107
91Hemiparesis (HP:0001269)1.88035720
92Narrow forehead (HP:0000341)1.87332261
93Short tibia (HP:0005736)1.86729241
94Hepatic necrosis (HP:0002605)1.86138411
95Large for gestational age (HP:0001520)1.84602729
96Keratoconus (HP:0000563)1.84464320
97Increased corneal curvature (HP:0100692)1.84464320
98Attenuation of retinal blood vessels (HP:0007843)1.83180637
99Hepatocellular necrosis (HP:0001404)1.82555026
100Hyperglycinuria (HP:0003108)1.81844146
101Septo-optic dysplasia (HP:0100842)1.78557742
102Aganglionic megacolon (HP:0002251)1.77893305
103Gastrointestinal atresia (HP:0002589)1.77662802
104Left ventricular hypertrophy (HP:0001712)1.77577001
105Optic nerve hypoplasia (HP:0000609)1.77341035
106Atelectasis (HP:0100750)1.75919450
107Abnormal hair whorl (HP:0010721)1.74888441
108Glycosuria (HP:0003076)1.74526827
109Abnormality of urine glucose concentration (HP:0011016)1.74526827
110Abnormality of macular pigmentation (HP:0008002)1.74270175
111Lissencephaly (HP:0001339)1.74136809
112Acute encephalopathy (HP:0006846)1.73745733
113Optic disc pallor (HP:0000543)1.73615720
114Broad-based gait (HP:0002136)1.73297008
115Menstrual irregularities (HP:0000858)1.72759218
116Hypoventilation (HP:0002791)1.72044281
117Missing ribs (HP:0000921)1.72010709
118Concave nail (HP:0001598)1.71563392
119Congenital hepatic fibrosis (HP:0002612)1.70461807
120Colon cancer (HP:0003003)1.70029138
121Aplasia/hypoplasia of the uterus (HP:0008684)1.68786946
122Dandy-Walker malformation (HP:0001305)1.68114575
123Supernumerary spleens (HP:0009799)1.67983307
12411 pairs of ribs (HP:0000878)1.67809572
125Anxiety (HP:0000739)1.67778135
126Abnormal urine output (HP:0012590)1.67615577
127Gout (HP:0001997)1.67602498
128Abnormality of permanent molar morphology (HP:0011071)1.67544377
129Abnormality of the dental root (HP:0006486)1.67544377
130Taurodontia (HP:0000679)1.67544377
131Symptomatic seizures (HP:0011145)1.67049804
132Renal Fanconi syndrome (HP:0001994)1.66622343
133Decreased central vision (HP:0007663)1.66406181
134Epileptiform EEG discharges (HP:0011182)1.65381055
135Labial hypoplasia (HP:0000066)1.63293293
136Abnormal pancreas size (HP:0012094)1.63090242
137Tubulointerstitial nephritis (HP:0001970)1.61901377
138Mitochondrial inheritance (HP:0001427)1.61725747
139Intestinal atresia (HP:0011100)1.61666979
140Abnormality of the dental pulp (HP:0006479)1.60056192
141Abnormality of potassium homeostasis (HP:0011042)1.59985376
142Retinal dysplasia (HP:0007973)1.59933030
143Abnormality of renal excretion (HP:0011036)1.59624471
144Myokymia (HP:0002411)1.58437052
145Abnormality of chloride homeostasis (HP:0011422)1.57026991
146Metabolic alkalosis (HP:0200114)1.56866357
147Abnormality of molar morphology (HP:0011070)1.56581385
148Abnormality of molar (HP:0011077)1.56581385
149EEG with generalized epileptiform discharges (HP:0011198)1.54878061
150Tetany (HP:0001281)1.54609503
151Adrenal overactivity (HP:0002717)1.54374651
152Pheochromocytoma (HP:0002666)1.52530987
153Absence seizures (HP:0002121)1.52014269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.98670095
2MAPK153.67598616
3NEK13.51301642
4SIK33.25415247
5MAP4K23.11578384
6MAP3K92.94827447
7NTRK32.92515252
8CASK2.47988239
9ERBB32.35038208
10ARAF2.33041245
11WNK32.27886283
12NUAK12.24718903
13PASK2.05460820
14KSR12.05016401
15PRKD32.03624067
16MAP2K71.96513850
17MINK11.96464811
18STK161.95430325
19ZAK1.86564176
20GRK11.86441030
21MST41.84809066
22MAP3K121.77222996
23ACVR1B1.77106950
24PRPF4B1.72020213
25TRIM281.71759356
26MAPK131.66623066
27NTRK21.60929600
28VRK21.59725954
29BCR1.59677541
30STK391.51579922
31WNK41.49664479
32PNCK1.48394918
33PLK21.46163624
34PINK11.43159901
35TLK11.39797302
36PHKG21.39313018
37PHKG11.39313018
38FGFR21.38494155
39TNIK1.36335423
40BRSK21.33897523
41DAPK21.25359747
42TESK11.23758066
43EPHA41.23382085
44VRK11.23244075
45MAP3K41.21684548
46SGK21.21597262
47BCKDK1.15656623
48DAPK11.14373655
49PAK31.12804871
50BMPR21.12801845
51SGK4941.11480047
52SGK2231.11480047
53INSRR1.09834366
54PDK31.09607724
55PDK41.09607724
56BRAF1.08367318
57KSR21.06897493
58WEE11.06501183
59MKNK21.05559698
60EPHB21.05270369
61MAP3K21.03425505
62ADRBK11.02497783
63PRKCG1.01607499
64CAMKK21.00453980
65FER1.00155257
66SIK21.00029054
67PTK2B0.99053263
68PIK3CG0.98016193
69MAP2K40.96633260
70UHMK10.93848856
71MARK10.93623303
72LMTK20.93382376
73GRK50.91753508
74MYLK0.90952681
75CSNK1G10.88774391
76HIPK20.88212004
77EPHA30.87309733
78ADRBK20.86720552
79PLK40.85322036
80MKNK10.84735288
81STK240.82704431
82LIMK10.82436190
83TGFBR10.81982375
84AKT30.80631067
85TSSK60.80229955
86PRKCE0.78820441
87CAMK2B0.72653561
88GRK70.72010701
89STK30.71459026
90MOS0.67899847
91CSNK1A1L0.66772588
92DYRK1A0.66037632
93DYRK20.64310650
94PLK30.64039058
95CAMK2A0.63782403
96TAOK30.61898755
97EIF2AK30.61865568
98TIE10.61643173
99CDK190.60610935
100OXSR10.58727900
101NTRK10.58084696
102CDK50.57683348
103PLK10.57108777
104TXK0.56528227
105CAMK2D0.54424356
106RPS6KA20.54076426
107PRKCI0.54059195
108CDK180.54008190
109BMPR1B0.53259992
110CDC42BPA0.52824299
111CSNK1G20.52526848
112MAP2K10.51235431
113CDK140.50343001
114MAP2K60.49543539
115MUSK0.49514002
116PIK3CA0.48893450
117PRKACA0.48385391
118DYRK30.46437636
119NEK20.43995482
120NEK60.41893074
121MAP3K60.41576809
122SGK30.41089432
123STK38L0.40081241
124OBSCN0.39206263
125NME10.38840034
126CDK150.38793127
127TTK0.38721922
128PRKACB0.38524145
129IRAK10.37174244
130PKN10.37062714
131ERBB20.37013794
132MAPKAPK50.36732138
133CAMK2G0.36015558
134PRKG10.35871230
135CDK11A0.35351131
136RPS6KA50.34015723
137CSNK1A10.33603576
138CSNK1G30.33296258
139CCNB10.33229528
140CDK30.33163958
141PTK20.32186315
142ATM0.31367871
143BUB10.30712835

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.17086983
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.96246510
3Vibrio cholerae infection_Homo sapiens_hsa051102.79789725
4Olfactory transduction_Homo sapiens_hsa047402.76697293
5Collecting duct acid secretion_Homo sapiens_hsa049662.74245737
6Synaptic vesicle cycle_Homo sapiens_hsa047212.65872615
7Insulin secretion_Homo sapiens_hsa049112.39074438
8Butanoate metabolism_Homo sapiens_hsa006502.35861693
9Amphetamine addiction_Homo sapiens_hsa050312.32590388
10Oxidative phosphorylation_Homo sapiens_hsa001902.32584337
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29052307
12Taste transduction_Homo sapiens_hsa047422.19580857
13* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.18577719
14Circadian entrainment_Homo sapiens_hsa047132.09816014
15Nicotine addiction_Homo sapiens_hsa050332.08961203
16Propanoate metabolism_Homo sapiens_hsa006402.08829793
17Dopaminergic synapse_Homo sapiens_hsa047282.01627439
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94871805
19Parkinsons disease_Homo sapiens_hsa050121.90990601
20Cocaine addiction_Homo sapiens_hsa050301.84521517
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80495848
22Nitrogen metabolism_Homo sapiens_hsa009101.78117530
23Linoleic acid metabolism_Homo sapiens_hsa005911.74994525
24RNA polymerase_Homo sapiens_hsa030201.70325967
25Morphine addiction_Homo sapiens_hsa050321.70221983
26GABAergic synapse_Homo sapiens_hsa047271.69957357
27Huntingtons disease_Homo sapiens_hsa050161.69704344
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66418258
29Alzheimers disease_Homo sapiens_hsa050101.59806911
30Serotonergic synapse_Homo sapiens_hsa047261.59061562
31Phototransduction_Homo sapiens_hsa047441.58240704
32Long-term potentiation_Homo sapiens_hsa047201.53693609
33Ribosome_Homo sapiens_hsa030101.50617802
34Homologous recombination_Homo sapiens_hsa034401.49228310
35Selenocompound metabolism_Homo sapiens_hsa004501.48445272
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42963116
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42915240
38Peroxisome_Homo sapiens_hsa041461.42623085
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41800704
40Fanconi anemia pathway_Homo sapiens_hsa034601.41635598
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41308577
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36711374
43Ether lipid metabolism_Homo sapiens_hsa005651.33774026
44Chemical carcinogenesis_Homo sapiens_hsa052041.31521503
45RNA degradation_Homo sapiens_hsa030181.30881226
46Gastric acid secretion_Homo sapiens_hsa049711.27678655
47Tryptophan metabolism_Homo sapiens_hsa003801.27548991
48Sulfur metabolism_Homo sapiens_hsa009201.25875821
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.24839319
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24207635
51Cholinergic synapse_Homo sapiens_hsa047251.23316956
52Steroid biosynthesis_Homo sapiens_hsa001001.22363412
53beta-Alanine metabolism_Homo sapiens_hsa004101.19924458
54Caffeine metabolism_Homo sapiens_hsa002321.18662110
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18578566
56Thyroid hormone synthesis_Homo sapiens_hsa049181.17077365
57N-Glycan biosynthesis_Homo sapiens_hsa005101.16961188
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16559069
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16124976
60Glutamatergic synapse_Homo sapiens_hsa047241.15941155
61One carbon pool by folate_Homo sapiens_hsa006701.12489643
62Renin secretion_Homo sapiens_hsa049241.07584875
63Circadian rhythm_Homo sapiens_hsa047101.02383942
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02231142
65Alcoholism_Homo sapiens_hsa050340.99586218
66Glucagon signaling pathway_Homo sapiens_hsa049220.99553293
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98820209
68Retinol metabolism_Homo sapiens_hsa008300.97683074
69Gap junction_Homo sapiens_hsa045400.97547413
70Fatty acid elongation_Homo sapiens_hsa000620.96825766
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96521604
72Long-term depression_Homo sapiens_hsa047300.96133758
73Melanogenesis_Homo sapiens_hsa049160.95944466
74Cardiac muscle contraction_Homo sapiens_hsa042600.95699530
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.94043998
76Salivary secretion_Homo sapiens_hsa049700.91775400
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90852208
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88421225
79Estrogen signaling pathway_Homo sapiens_hsa049150.88198111
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86941643
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86839951
82cAMP signaling pathway_Homo sapiens_hsa040240.85599434
83Proteasome_Homo sapiens_hsa030500.83680446
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83365801
85Calcium signaling pathway_Homo sapiens_hsa040200.82605173
86Metabolic pathways_Homo sapiens_hsa011000.82174046
87Histidine metabolism_Homo sapiens_hsa003400.78923410
88Glutathione metabolism_Homo sapiens_hsa004800.78070610
89Oocyte meiosis_Homo sapiens_hsa041140.76951352
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76487977
91Arachidonic acid metabolism_Homo sapiens_hsa005900.74071350
92Non-homologous end-joining_Homo sapiens_hsa034500.73747255
93Fatty acid degradation_Homo sapiens_hsa000710.73724607
94ABC transporters_Homo sapiens_hsa020100.72863285
95Nucleotide excision repair_Homo sapiens_hsa034200.70892620
96GnRH signaling pathway_Homo sapiens_hsa049120.70819009
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70743382
98Wnt signaling pathway_Homo sapiens_hsa043100.68537474
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68407085
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67936501
101Tyrosine metabolism_Homo sapiens_hsa003500.67621635
102Fatty acid metabolism_Homo sapiens_hsa012120.67607922
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67047344
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66330756
105Oxytocin signaling pathway_Homo sapiens_hsa049210.65853855
106Hedgehog signaling pathway_Homo sapiens_hsa043400.65006657
107Mismatch repair_Homo sapiens_hsa034300.64728180
108Fat digestion and absorption_Homo sapiens_hsa049750.64520783
109Pyruvate metabolism_Homo sapiens_hsa006200.64185650
110Type I diabetes mellitus_Homo sapiens_hsa049400.63739666
111Folate biosynthesis_Homo sapiens_hsa007900.62894502
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62779095
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62571270
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58199470
115Phagosome_Homo sapiens_hsa041450.55484318
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.55443591
117Pancreatic secretion_Homo sapiens_hsa049720.53004801
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.52274687
119Axon guidance_Homo sapiens_hsa043600.50650815
120Purine metabolism_Homo sapiens_hsa002300.50034091
121Rheumatoid arthritis_Homo sapiens_hsa053230.50016046
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48539825
123Prion diseases_Homo sapiens_hsa050200.48357308
124RNA transport_Homo sapiens_hsa030130.48168563
125Ovarian steroidogenesis_Homo sapiens_hsa049130.47860538
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47433636
127Hippo signaling pathway_Homo sapiens_hsa043900.47015227
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46944064
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46612933
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45306261
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42896760
132Pyrimidine metabolism_Homo sapiens_hsa002400.42687733
133Type II diabetes mellitus_Homo sapiens_hsa049300.41894544
134Melanoma_Homo sapiens_hsa052180.41277960
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40626959
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39013584
137Regulation of autophagy_Homo sapiens_hsa041400.38927433
138Arginine and proline metabolism_Homo sapiens_hsa003300.36995785
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36835815
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34965980
141Tight junction_Homo sapiens_hsa045300.34360125
142Glycerolipid metabolism_Homo sapiens_hsa005610.33881009
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33809872
144Phenylalanine metabolism_Homo sapiens_hsa003600.31707782
145Bladder cancer_Homo sapiens_hsa052190.31430035
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30636621
147TGF-beta signaling pathway_Homo sapiens_hsa043500.30193450
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29943432
149Basal transcription factors_Homo sapiens_hsa030220.29798090
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29771529
151Dilated cardiomyopathy_Homo sapiens_hsa054140.29306732
152Basal cell carcinoma_Homo sapiens_hsa052170.28027198
153ErbB signaling pathway_Homo sapiens_hsa040120.27991249
154Ras signaling pathway_Homo sapiens_hsa040140.27661241
155Glioma_Homo sapiens_hsa052140.27344626
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27250131

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »