DYNLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.64374753
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.44294706
3ATP synthesis coupled proton transport (GO:0015986)6.44294706
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.32081456
5axonemal dynein complex assembly (GO:0070286)4.95151106
6protein neddylation (GO:0045116)4.85252316
7respiratory electron transport chain (GO:0022904)4.68264890
8electron transport chain (GO:0022900)4.58544171
9chaperone-mediated protein transport (GO:0072321)4.55404026
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.31620943
11ribosomal small subunit biogenesis (GO:0042274)4.26344465
12GTP biosynthetic process (GO:0006183)4.19377891
13viral transcription (GO:0019083)3.87511893
14translational termination (GO:0006415)3.75082500
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71891684
16neuron cell-cell adhesion (GO:0007158)3.69370521
17long-chain fatty acid biosynthetic process (GO:0042759)3.69196805
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69072820
19cullin deneddylation (GO:0010388)3.67069154
20UTP biosynthetic process (GO:0006228)3.57284747
21cilium movement (GO:0003341)3.55555219
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55192824
23protein maturation by protein folding (GO:0022417)3.53345172
24epithelial cilium movement (GO:0003351)3.48569776
25establishment of integrated proviral latency (GO:0075713)3.48363048
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47003310
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.47003310
28NADH dehydrogenase complex assembly (GO:0010257)3.47003310
29cotranslational protein targeting to membrane (GO:0006613)3.38952488
30regulation of cilium movement (GO:0003352)3.36237686
31termination of RNA polymerase III transcription (GO:0006386)3.35676321
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.35676321
33protein deneddylation (GO:0000338)3.31127076
34protein complex biogenesis (GO:0070271)3.30420076
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30336413
36protein targeting to ER (GO:0045047)3.29483087
37regulation of mitochondrial translation (GO:0070129)3.28902458
38axon ensheathment in central nervous system (GO:0032291)3.28351653
39central nervous system myelination (GO:0022010)3.28351653
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27774432
41hydrogen ion transmembrane transport (GO:1902600)3.27561188
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25725271
43respiratory chain complex IV assembly (GO:0008535)3.25238456
44cellular protein complex disassembly (GO:0043624)3.22728603
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19623800
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19286450
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18825596
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17847366
49aldehyde catabolic process (GO:0046185)3.17503261
50protein localization to endoplasmic reticulum (GO:0070972)3.13328676
51guanosine-containing compound biosynthetic process (GO:1901070)3.12573631
52positive regulation of ligase activity (GO:0051351)3.11805583
53positive regulation of cellular response to oxidative stress (GO:1900409)3.09925940
54positive regulation of response to oxidative stress (GO:1902884)3.09925940
55regulation of glutamate secretion (GO:0014048)3.09128439
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08721502
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08721502
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06880699
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06880699
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06880699
61viral life cycle (GO:0019058)3.05345474
62CENP-A containing nucleosome assembly (GO:0034080)3.05315252
63ATP biosynthetic process (GO:0006754)3.04895990
64ribosomal small subunit assembly (GO:0000028)3.03841245
65translational elongation (GO:0006414)3.00584855
66establishment of viral latency (GO:0019043)3.00351407
67chromatin remodeling at centromere (GO:0031055)2.99772796
68negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99669631
69signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97483223
70signal transduction involved in DNA damage checkpoint (GO:0072422)2.97483223
71regulation of ubiquitin-protein transferase activity (GO:0051438)2.96251197
72regulation of cellular amine metabolic process (GO:0033238)2.94973163
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.94939666
74mitochondrial respiratory chain complex assembly (GO:0033108)2.94930580
75nucleoside diphosphate phosphorylation (GO:0006165)2.94272204
76ATP hydrolysis coupled proton transport (GO:0015991)2.94035328
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.94035328
78proteasome assembly (GO:0043248)2.92800143
79protein localization to synapse (GO:0035418)2.92376183
80neuron recognition (GO:0008038)2.91120523
81proton transport (GO:0015992)2.91114564
82UTP metabolic process (GO:0046051)2.90548614
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90241621
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90218753
85rRNA modification (GO:0000154)2.89560352
86presynaptic membrane assembly (GO:0097105)2.89263576
877-methylguanosine mRNA capping (GO:0006370)2.89224652
88RNA capping (GO:0036260)2.88850547
897-methylguanosine RNA capping (GO:0009452)2.88850547
90presynaptic membrane organization (GO:0097090)2.88340829
91cytochrome complex assembly (GO:0017004)2.88144864
92oxidative phosphorylation (GO:0006119)2.88024431
93keratinocyte development (GO:0003334)2.87639975
94regulation of ligase activity (GO:0051340)2.85790251
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.85063614
96translational initiation (GO:0006413)2.84158745
97motile cilium assembly (GO:0044458)2.82543258
98hydrogen transport (GO:0006818)2.81686087
99calcium-mediated signaling using intracellular calcium source (GO:0035584)2.77501523
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77399768
101maturation of SSU-rRNA (GO:0030490)2.75314906
102CTP biosynthetic process (GO:0006241)2.74676268
103CTP metabolic process (GO:0046036)2.74676268
104dopamine transport (GO:0015872)2.74386282
105regulation of neuron projection regeneration (GO:0070570)2.72655901
106regulation of axon regeneration (GO:0048679)2.72655901
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72003888
108mitochondrial transport (GO:0006839)2.71292181
109protein localization to cilium (GO:0061512)2.69727337
110establishment of protein localization to mitochondrion (GO:0072655)2.68845729
111ribosomal large subunit biogenesis (GO:0042273)2.68577912
112negative regulation of microtubule polymerization (GO:0031115)2.68566040
113spliceosomal snRNP assembly (GO:0000387)2.67982089
114translation (GO:0006412)2.67819054
115de novo protein folding (GO:0006458)2.67573452
116glutamate receptor signaling pathway (GO:0007215)2.67412023
117regulation of dopamine metabolic process (GO:0042053)2.66711275
118regulation of catecholamine metabolic process (GO:0042069)2.66711275
119cilium or flagellum-dependent cell motility (GO:0001539)2.65620308
120protein complex disassembly (GO:0043241)2.64320932
121protein targeting to mitochondrion (GO:0006626)2.63854459
122nucleobase-containing small molecule interconversion (GO:0015949)2.61781109
123axoneme assembly (GO:0035082)2.60487430
124positive regulation of synapse assembly (GO:0051965)2.60484097
125regulation of oxidative phosphorylation (GO:0002082)2.60193450
126negative regulation of neurotransmitter transport (GO:0051589)2.60189218
127synaptic transmission, dopaminergic (GO:0001963)2.59823881
128histone exchange (GO:0043486)2.57315415
129RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57087743
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57087743
131intraciliary transport (GO:0042073)2.55570251
132negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55271133
133protein localization to mitochondrion (GO:0070585)2.54959427
134cellular component biogenesis (GO:0044085)2.54925851
135macromolecular complex disassembly (GO:0032984)2.54785623
136de novo posttranslational protein folding (GO:0051084)2.54574925
137axonal fasciculation (GO:0007413)2.53757768
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.53006034
139nucleoside triphosphate biosynthetic process (GO:0009142)2.52899398
140negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.51465344
141left/right pattern formation (GO:0060972)2.51121009
142neuronal action potential propagation (GO:0019227)2.50814611
143* substantia nigra development (GO:0021762)2.49598326
144deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.49443300
145regulation of cellular amino acid metabolic process (GO:0006521)2.48903934
146negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47017893
147dopamine biosynthetic process (GO:0042416)2.46271745
148DNA damage response, detection of DNA damage (GO:0042769)2.43939639
149negative regulation of ligase activity (GO:0051352)2.41881055
150negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.41881055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.85876108
2EZH2_22144423_ChIP-Seq_EOC_Human3.84593974
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83973723
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60441592
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98196210
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80613251
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79286050
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.65078940
9GBX2_23144817_ChIP-Seq_PC3_Human2.54993475
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.51200245
11VDR_22108803_ChIP-Seq_LS180_Human2.41060268
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29869565
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21834321
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18531576
15FUS_26573619_Chip-Seq_HEK293_Human2.15954990
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15054311
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.13106559
18TAF15_26573619_Chip-Seq_HEK293_Human2.11469779
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09265511
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.08686902
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08432543
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.98753878
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95183605
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94418434
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93911494
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93327103
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91562698
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91512053
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89602714
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86663982
31* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83798508
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.82302834
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79996675
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.79591752
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75110980
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74506195
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.73671865
38GABP_19822575_ChIP-Seq_HepG2_Human1.72194630
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71620395
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68681473
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67655739
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66434606
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66434606
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66194106
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64227758
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64198164
47* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64095559
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63407934
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57887498
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52750814
51P300_19829295_ChIP-Seq_ESCs_Human1.50935315
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49407802
53FOXP3_21729870_ChIP-Seq_TREG_Human1.49166937
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47919170
55AR_21909140_ChIP-Seq_LNCAP_Human1.47787526
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45733230
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44292311
58RNF2_27304074_Chip-Seq_NSC_Mouse1.39502800
59EWS_26573619_Chip-Seq_HEK293_Human1.39328551
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34466501
61REST_21632747_ChIP-Seq_MESCs_Mouse1.32925567
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32826206
63TTF2_22483619_ChIP-Seq_HELA_Human1.30432929
64* ELK1_19687146_ChIP-ChIP_HELA_Human1.30260643
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.29521859
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28904863
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28118598
68DCP1A_22483619_ChIP-Seq_HELA_Human1.27925481
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27593058
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27475902
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26710495
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26672056
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26579852
74* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25719657
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25490661
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24852554
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.24817233
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24630455
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24117155
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24061614
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.23914784
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22849327
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22022813
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21100445
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20341654
86ER_23166858_ChIP-Seq_MCF-7_Human1.18734895
87ZNF274_21170338_ChIP-Seq_K562_Hela1.18061536
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15787529
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15673529
90* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15171101
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15063380
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14828178
93JUN_21703547_ChIP-Seq_K562_Human1.14267813
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13356283
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12053897
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11337000
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11216001
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11065479
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10675798
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.09774550
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.09425604
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09401655
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09102843
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08958317
105* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08332606
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08309578
107XRN2_22483619_ChIP-Seq_HELA_Human1.07791190
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.07594841
109VDR_23849224_ChIP-Seq_CD4+_Human1.06077687
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.04249946
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03951335
112* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02140314
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01386656
114REST_18959480_ChIP-ChIP_MESCs_Mouse1.00908136
115MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00217233
116ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99216997
117SMAD4_21799915_ChIP-Seq_A2780_Human0.98485836
118MYC_18940864_ChIP-ChIP_HL60_Human0.98388134
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97798786
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96461104
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96434400
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96262784
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94789696
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.94639871
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.94239067
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94209570
127* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94113314
128IRF1_19129219_ChIP-ChIP_H3396_Human0.94049679
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94006157
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92253370
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91575276
132EOMES_21245162_ChIP-Seq_HESCs_Human0.91493911
133AR_21572438_ChIP-Seq_LNCaP_Human0.91335712
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90841817
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90218312
136SOX9_26525672_Chip-Seq_HEART_Mouse0.90008532
137ZNF263_19887448_ChIP-Seq_K562_Human0.89786690
138HTT_18923047_ChIP-ChIP_STHdh_Human0.89430925
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86910726
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86868476
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.85022713
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.84399601
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84334340
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83996074
145OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83912358
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83840409
147CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83559945
148TP53_18474530_ChIP-ChIP_U2OS_Human0.83076873
149PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82592147
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.79420523
151TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77466868
152NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76099817
153CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75561464
154ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75211587
155* FOXP1_21924763_ChIP-Seq_HESCs_Human0.74219972
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71551517
157* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71299665
158TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.70229187
159* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70208550
160* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.69608457
161RBPJ_21746931_ChIP-Seq_IB4_Human0.68027213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.61685055
2MP0009379_abnormal_foot_pigmentation3.41148677
3MP0001529_abnormal_vocalization3.04101461
4MP0004859_abnormal_synaptic_plasticity2.94081534
5MP0001968_abnormal_touch/_nociception2.71430468
6MP0002736_abnormal_nociception_after2.67604645
7MP0004270_analgesia2.64492409
8MP0003186_abnormal_redox_activity2.57939830
9MP0001905_abnormal_dopamine_level2.40341943
10MP0003635_abnormal_synaptic_transmissio2.38941229
11MP0003136_yellow_coat_color2.33279353
12MP0006276_abnormal_autonomic_nervous2.31202981
13MP0009745_abnormal_behavioral_response2.24214752
14MP0002735_abnormal_chemical_nociception2.13658292
15MP0001440_abnormal_grooming_behavior2.10834865
16MP0000778_abnormal_nervous_system2.09216904
17MP0002063_abnormal_learning/memory/cond2.05333717
18MP0002734_abnormal_mechanical_nocicepti2.03812762
19MP0002272_abnormal_nervous_system2.02408198
20MP0002064_seizures2.00236903
21MP0002572_abnormal_emotion/affect_behav1.95124648
22MP0001188_hyperpigmentation1.91557421
23MP0003806_abnormal_nucleotide_metabolis1.86136424
24MP0008058_abnormal_DNA_repair1.84532138
25MP0006036_abnormal_mitochondrial_physio1.82817597
26MP0005409_darkened_coat_color1.78068288
27MP0008875_abnormal_xenobiotic_pharmacok1.76299646
28MP0009780_abnormal_chondrocyte_physiolo1.71592285
29MP0003693_abnormal_embryo_hatching1.70049663
30MP0001970_abnormal_pain_threshold1.68648997
31MP0002184_abnormal_innervation1.63162502
32MP0005423_abnormal_somatic_nervous1.62902946
33MP0001486_abnormal_startle_reflex1.60045769
34MP0002733_abnormal_thermal_nociception1.55841893
35MP0003122_maternal_imprinting1.55468735
36MP0002102_abnormal_ear_morphology1.50704987
37MP0009046_muscle_twitch1.49865221
38MP0006292_abnormal_olfactory_placode1.44649854
39MP0005171_absent_coat_pigmentation1.42191323
40MP0002067_abnormal_sensory_capabilities1.40651779
41MP0004742_abnormal_vestibular_system1.40142362
42MP0001984_abnormal_olfaction1.40041751
43MP0003315_abnormal_perineum_morphology1.39417479
44MP0003938_abnormal_ear_development1.38963764
45MP0001501_abnormal_sleep_pattern1.36817083
46MP0000579_abnormal_nail_morphology1.31970605
47MP0005084_abnormal_gallbladder_morpholo1.31802609
48MP0004142_abnormal_muscle_tone1.31726419
49MP0003011_delayed_dark_adaptation1.28488126
50MP0008007_abnormal_cellular_replicative1.22209503
51MP0002163_abnormal_gland_morphology1.20466466
52MP0008932_abnormal_embryonic_tissue1.20252889
53MP0002233_abnormal_nose_morphology1.18338396
54MP0002882_abnormal_neuron_morphology1.16049154
55MP0002557_abnormal_social/conspecific_i1.15656533
56MP0001485_abnormal_pinna_reflex1.13878781
57MP0006035_abnormal_mitochondrial_morpho1.13750292
58MP0005410_abnormal_fertilization1.12428295
59MP0000955_abnormal_spinal_cord1.12240094
60MP0004147_increased_porphyrin_level1.12060998
61MP0000920_abnormal_myelination1.11064921
62MP0010094_abnormal_chromosome_stability1.10458133
63MP0008789_abnormal_olfactory_epithelium1.10436397
64MP0003941_abnormal_skin_development1.10216397
65MP0006072_abnormal_retinal_apoptosis1.09320464
66MP0002752_abnormal_somatic_nervous1.08957704
67MP0005646_abnormal_pituitary_gland1.08754278
68MP0003123_paternal_imprinting1.07911124
69MP0003786_premature_aging1.07205868
70MP0003077_abnormal_cell_cycle1.05751603
71MP0003111_abnormal_nucleus_morphology1.05152277
72MP0000762_abnormal_tongue_morphology1.04633594
73MP0005394_taste/olfaction_phenotype1.04352811
74MP0005499_abnormal_olfactory_system1.04352811
75MP0008872_abnormal_physiological_respon1.04302045
76MP0009250_abnormal_appendicular_skeleto1.03286439
77MP0002751_abnormal_autonomic_nervous1.02634917
78MP0002837_dystrophic_cardiac_calcinosis1.02490911
79MP0005386_behavior/neurological_phenoty1.02126721
80MP0004924_abnormal_behavior1.02126721
81MP0003329_amyloid_beta_deposits1.00071789
82MP0005501_abnormal_skin_physiology0.99231913
83MP0001963_abnormal_hearing_physiology0.98647162
84MP0002938_white_spotting0.97507664
85MP0000026_abnormal_inner_ear0.97323378
86MP0002638_abnormal_pupillary_reflex0.96232433
87MP0000358_abnormal_cell_content/0.95148478
88MP0005623_abnormal_meninges_morphology0.94243025
89MP0002796_impaired_skin_barrier0.94235775
90MP0000049_abnormal_middle_ear0.93884080
91MP0002066_abnormal_motor_capabilities/c0.93663004
92MP0004381_abnormal_hair_follicle0.92927888
93MP0000631_abnormal_neuroendocrine_gland0.92764930
94MP0002282_abnormal_trachea_morphology0.92724537
95MP0004145_abnormal_muscle_electrophysio0.92084075
96MP0009053_abnormal_anal_canal0.91517724
97MP0005551_abnormal_eye_electrophysiolog0.91463257
98MP0001293_anophthalmia0.91370674
99MP0000647_abnormal_sebaceous_gland0.90697175
100MP0002152_abnormal_brain_morphology0.89983383
101MP0000372_irregular_coat_pigmentation0.89420640
102MP0001299_abnormal_eye_distance/0.89381199
103MP0002234_abnormal_pharynx_morphology0.88889278
104MP0010386_abnormal_urinary_bladder0.87304040
105MP0004885_abnormal_endolymph0.85861155
106MP0001727_abnormal_embryo_implantation0.84831227
107MP0003119_abnormal_digestive_system0.84070528
108MP0002210_abnormal_sex_determination0.83704533
109MP0002277_abnormal_respiratory_mucosa0.83641992
110MP0004019_abnormal_vitamin_homeostasis0.83572141
111MP0003121_genomic_imprinting0.83146773
112MP0005389_reproductive_system_phenotype0.82450369
113MP0003861_abnormal_nervous_system0.81453488
114MP0004811_abnormal_neuron_physiology0.81293111
115MP0004957_abnormal_blastocyst_morpholog0.80762666
116MP0008877_abnormal_DNA_methylation0.80032109
117MP0003937_abnormal_limbs/digits/tail_de0.80020413
118MP0004133_heterotaxia0.79776180
119MP0005379_endocrine/exocrine_gland_phen0.76505951
120MP0002090_abnormal_vision0.76305657
121MP0003755_abnormal_palate_morphology0.74495004
122MP0005253_abnormal_eye_physiology0.74331962
123MP0001929_abnormal_gametogenesis0.73835159
124MP0003942_abnormal_urinary_system0.72808844
125MP0009697_abnormal_copulation0.71744799
126MP0002249_abnormal_larynx_morphology0.70746631
127MP0002160_abnormal_reproductive_system0.70392601
128MP0003385_abnormal_body_wall0.68390483
129MP0003718_maternal_effect0.67408465
130MP0010030_abnormal_orbit_morphology0.65714881
131MP0001542_abnormal_bone_strength0.65256337
132MP0003634_abnormal_glial_cell0.65203576
133MP0001664_abnormal_digestion0.64982686
134MP0010771_integument_phenotype0.62107464
135MP0002229_neurodegeneration0.61281180
136MP0001340_abnormal_eyelid_morphology0.60940886
137MP0002653_abnormal_ependyma_morphology0.60769880
138MP0005645_abnormal_hypothalamus_physiol0.60768841

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.32358672
2Abnormal mitochondria in muscle tissue (HP:0008316)4.50906714
3Progressive macrocephaly (HP:0004481)4.49515316
4Mitochondrial inheritance (HP:0001427)4.34996009
5Chronic bronchitis (HP:0004469)3.94282749
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.88727754
7Acute encephalopathy (HP:0006846)3.81394783
8Increased hepatocellular lipid droplets (HP:0006565)3.60425606
9Increased CSF lactate (HP:0002490)3.49318913
10Focal motor seizures (HP:0011153)3.41726181
11Myokymia (HP:0002411)3.40062694
12Abnormality of glycolysis (HP:0004366)3.13582826
13Increased serum pyruvate (HP:0003542)3.13582826
14Hepatocellular necrosis (HP:0001404)3.05984527
15Optic disc pallor (HP:0000543)2.99177934
16Abnormal ciliary motility (HP:0012262)2.97813169
17Abnormality of cells of the erythroid lineage (HP:0012130)2.95660758
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92978713
19Renal Fanconi syndrome (HP:0001994)2.92689959
20Parakeratosis (HP:0001036)2.86967419
21Abnormal respiratory motile cilium physiology (HP:0012261)2.83844933
22Abnormal respiratory motile cilium morphology (HP:0005938)2.83309875
23Abnormal respiratory epithelium morphology (HP:0012253)2.83309875
24Lipid accumulation in hepatocytes (HP:0006561)2.81674301
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.81126322
26Bronchiectasis (HP:0002110)2.80890575
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.80889479
28Leukodystrophy (HP:0002415)2.79584594
29Delusions (HP:0000746)2.70810689
303-Methylglutaconic aciduria (HP:0003535)2.70738512
31Congenital ichthyosiform erythroderma (HP:0007431)2.59492483
32Exercise intolerance (HP:0003546)2.55389547
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.50014576
34Absent/shortened dynein arms (HP:0200106)2.50014576
35Abnormality of midbrain morphology (HP:0002418)2.44643762
36Molar tooth sign on MRI (HP:0002419)2.44643762
37Respiratory failure (HP:0002878)2.44006315
38Sensory axonal neuropathy (HP:0003390)2.43388448
39Medial flaring of the eyebrow (HP:0010747)2.39419355
40Abnormality of the anterior horn cell (HP:0006802)2.38602708
41Degeneration of anterior horn cells (HP:0002398)2.38602708
42Sparse eyelashes (HP:0000653)2.32833783
43Abnormal number of erythroid precursors (HP:0012131)2.28043447
44Amblyopia (HP:0000646)2.27778867
45Occipital encephalocele (HP:0002085)2.27754497
46Gait imbalance (HP:0002141)2.27553242
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.26332576
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26332576
49Infertility (HP:0000789)2.24688135
50Macrocytic anemia (HP:0001972)2.23639063
51Rhinitis (HP:0012384)2.21666975
52Congenital primary aphakia (HP:0007707)2.17380341
53Male infertility (HP:0003251)2.17239211
54Genital tract atresia (HP:0001827)2.16298255
55Cerebral hypomyelination (HP:0006808)2.15435619
56Atonic seizures (HP:0010819)2.14336341
57Focal seizures (HP:0007359)2.13943784
58Vaginal atresia (HP:0000148)2.13780749
59Exertional dyspnea (HP:0002875)2.11814561
60Epileptic encephalopathy (HP:0200134)2.11412187
61Pancreatic cysts (HP:0001737)2.09388534
62Cerebral inclusion bodies (HP:0100314)2.08438403
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08228155
64Oral leukoplakia (HP:0002745)2.07578082
65Cerebral edema (HP:0002181)2.06151161
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03581805
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03581805
68Stenosis of the external auditory canal (HP:0000402)2.01653640
69X-linked dominant inheritance (HP:0001423)2.00879198
70Amniotic constriction ring (HP:0009775)2.00360574
71Abnormality of placental membranes (HP:0011409)2.00360574
72Increased muscle lipid content (HP:0009058)1.97937331
73Nephrogenic diabetes insipidus (HP:0009806)1.97449595
74Reticulocytopenia (HP:0001896)1.97438667
75Double outlet right ventricle (HP:0001719)1.97388904
76Congenital malformation of the right heart (HP:0011723)1.97388904
77Retinal dysplasia (HP:0007973)1.95206892
78Hepatic necrosis (HP:0002605)1.94521805
79Nasal polyposis (HP:0100582)1.93751403
80Increased serum lactate (HP:0002151)1.91568060
81CNS demyelination (HP:0007305)1.91212820
82Poor suck (HP:0002033)1.91042450
83Abnormality of the labia minora (HP:0012880)1.90234034
84Abnormality of secondary sexual hair (HP:0009888)1.88847469
85Abnormality of the axillary hair (HP:0100134)1.88847469
86Abnormality of renal resorption (HP:0011038)1.88628490
87Adrenal hypoplasia (HP:0000835)1.85955214
88Hyperventilation (HP:0002883)1.85394076
89Lactic acidosis (HP:0003128)1.84866575
90Abnormal autonomic nervous system physiology (HP:0012332)1.84623999
91Visual hallucinations (HP:0002367)1.84569679
92Congenital, generalized hypertrichosis (HP:0004540)1.84268125
93Hydroureter (HP:0000072)1.84109324
94Increased intramyocellular lipid droplets (HP:0012240)1.84104796
95Respiratory difficulties (HP:0002880)1.82641917
96Hypoplastic pelvis (HP:0008839)1.82541438
97Lethargy (HP:0001254)1.82169251
98Dialeptic seizures (HP:0011146)1.82129972
99Male pseudohermaphroditism (HP:0000037)1.79016910
100Broad-based gait (HP:0002136)1.78582752
101Neurofibrillary tangles (HP:0002185)1.78222664
102Concave nail (HP:0001598)1.77922573
103Facial cleft (HP:0002006)1.77330405
104Aplasia/hypoplasia of the uterus (HP:0008684)1.75874617
105Absence seizures (HP:0002121)1.75475239
106Progressive cerebellar ataxia (HP:0002073)1.72562516
107Focal dystonia (HP:0004373)1.71957208
108Type I transferrin isoform profile (HP:0003642)1.71916146
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.71723762
110Supernumerary spleens (HP:0009799)1.71410465
111Median cleft lip (HP:0000161)1.71097356
112Postaxial foot polydactyly (HP:0001830)1.70954852
113Emotional lability (HP:0000712)1.69973430
114Pancreatic fibrosis (HP:0100732)1.69783496
115Pallor (HP:0000980)1.69491702
116Rough bone trabeculation (HP:0100670)1.69402189
117Breast hypoplasia (HP:0003187)1.67582646
118Craniofacial dystonia (HP:0012179)1.66954388
119Anencephaly (HP:0002323)1.66833402
120Abnormal hair whorl (HP:0010721)1.65349255
121Aplastic anemia (HP:0001915)1.63284045
122Limb dystonia (HP:0002451)1.63072258
123Sclerocornea (HP:0000647)1.62936915
124Nephronophthisis (HP:0000090)1.62416335
125Polyphagia (HP:0002591)1.61757654
126True hermaphroditism (HP:0010459)1.60859465
127Hyperphosphaturia (HP:0003109)1.59051178
128Dysautonomia (HP:0002459)1.58971976
129Abnormality of aromatic amino acid family metabolism (HP:0004338)1.57792185
130CNS hypomyelination (HP:0003429)1.56866601
131Hyperthyroidism (HP:0000836)1.54648082
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.53426296
133Short tibia (HP:0005736)1.52440167
134Cupped ear (HP:0000378)1.51404145
135Esotropia (HP:0000565)1.50459869
136Abnormality of dentin (HP:0010299)1.50266816
137Irregular epiphyses (HP:0010582)1.50121388
138Abnormality of the corticospinal tract (HP:0002492)1.48829269
139Heterochromia iridis (HP:0001100)1.48141558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.37110478
2EPHA43.25056220
3MAP3K123.11764937
4CASK2.99895890
5PNCK2.87607600
6NME12.73709193
7GRK52.60007060
8PLK22.46373032
9RIPK42.36401962
10ARAF2.32232389
11NTRK32.17296974
12MST42.10343032
13BUB12.10220356
14STK391.94867569
15BCR1.90787286
16LIMK11.90133972
17NEK11.82907912
18STK161.81865384
19TRIM281.81750470
20NME21.63644085
21FGR1.62514652
22TTK1.61390354
23PTK2B1.60518094
24BMPR21.56565212
25MAP2K71.53749353
26MINK11.51427686
27OXSR11.47862025
28CDC71.47539614
29CDK191.43849358
30VRK11.40865003
31MAP3K41.40610617
32PBK1.39166985
33TNIK1.35948780
34BRSK11.35368888
35WEE11.27601008
36EIF2AK11.26830807
37MAP3K91.25083027
38FES1.24448361
39EPHA21.23382566
40MAPK151.23098100
41DYRK21.22364125
42MARK11.21993262
43CAMK2B1.20084411
44PLK11.20047383
45GRK71.18469119
46MAPK131.18057749
47SRPK11.07756544
48WNK31.06506419
49PLK31.06021584
50MAPKAPK51.05946051
51BRAF1.05522274
52TLK11.03371789
53CAMK2A1.03245829
54MYLK1.02606906
55PAK41.00339697
56CDK140.98832173
57UHMK10.98687929
58PDK20.98122531
59TESK10.96062012
60ROCK20.94945805
61TESK20.94788036
62DAPK10.93744164
63ZAK0.88217385
64BCKDK0.88111012
65ADRBK10.86074961
66CDK180.86010198
67BMPR1B0.85840543
68BRSK20.84985740
69TSSK60.81936382
70PIM20.81920601
71DYRK1A0.81141912
72CDK150.81028203
73PRKCG0.77857325
74NUAK10.77345367
75GRK60.77287536
76ADRBK20.76812712
77EIF2AK30.76769274
78KSR10.76299456
79MKNK10.76142417
80CDK11A0.75984680
81EPHB20.73780385
82CSNK1G30.73571324
83CDK80.72651728
84AURKB0.72476478
85WNK40.72405633
86LATS20.71751988
87AURKA0.71641305
88FER0.71392406
89MAP2K40.71068534
90PAK60.70181936
91NTRK10.69796637
92CAMK2D0.67769121
93CDK50.66882827
94LMTK20.63624699
95RAF10.63596496
96ILK0.63344890
97DMPK0.62722409
98NTRK20.62532067
99MKNK20.61840664
100ABL20.60911875
101MUSK0.59683237
102MAP4K20.58612872
103PRKCE0.56984112
104CSNK1G20.56426476
105* PAK10.56147416
106DAPK30.54799608
107ERBB40.52996630
108KSR20.52837544
109PLK40.52730254
110LRRK20.51947817
111CCNB10.51561965
112MAPKAPK30.51200602
113PRKD30.50957422
114ERBB30.50349513
115TYRO30.48662391
116PAK30.47837295
117CHEK20.47832627
118MOS0.46999856
119CAMK2G0.46474197
120PKN10.46041628
121DAPK20.44758254
122PRPF4B0.44572116
123PRKCI0.44317336
124CSNK1E0.43861113
125YES10.39881439
126CSNK2A20.39645465
127CSNK1A1L0.37704759
128PRKACA0.37380199
129CSNK1G10.37111945
130CSNK2A10.35129328
131CLK10.32933208
132SIK30.32562748

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.80051531
2Parkinsons disease_Homo sapiens_hsa050123.93113678
3Ribosome_Homo sapiens_hsa030103.66248521
4Alzheimers disease_Homo sapiens_hsa050103.30185883
5Huntingtons disease_Homo sapiens_hsa050163.09276621
6Proteasome_Homo sapiens_hsa030503.06782474
7RNA polymerase_Homo sapiens_hsa030202.71537115
8Nicotine addiction_Homo sapiens_hsa050332.38323736
9Collecting duct acid secretion_Homo sapiens_hsa049662.29558413
10Cardiac muscle contraction_Homo sapiens_hsa042602.15585417
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08651898
12Protein export_Homo sapiens_hsa030601.91586185
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86004538
14Glutathione metabolism_Homo sapiens_hsa004801.75939560
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66914385
16Phototransduction_Homo sapiens_hsa047441.65340447
17Long-term potentiation_Homo sapiens_hsa047201.62476949
18Synaptic vesicle cycle_Homo sapiens_hsa047211.62194912
19Folate biosynthesis_Homo sapiens_hsa007901.61391031
20Amphetamine addiction_Homo sapiens_hsa050311.57898104
21Serotonergic synapse_Homo sapiens_hsa047261.56232964
22Vibrio cholerae infection_Homo sapiens_hsa051101.52325365
23Glutamatergic synapse_Homo sapiens_hsa047241.46183870
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42092779
25Base excision repair_Homo sapiens_hsa034101.41313540
26Circadian entrainment_Homo sapiens_hsa047131.37162948
27Dopaminergic synapse_Homo sapiens_hsa047281.35589247
28Vitamin B6 metabolism_Homo sapiens_hsa007501.35565679
29Spliceosome_Homo sapiens_hsa030401.29614804
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27100251
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24825554
32Olfactory transduction_Homo sapiens_hsa047401.24780097
33Taste transduction_Homo sapiens_hsa047421.24246168
34Long-term depression_Homo sapiens_hsa047301.22977419
35Pyruvate metabolism_Homo sapiens_hsa006201.22483693
36Morphine addiction_Homo sapiens_hsa050321.21067708
37Basal transcription factors_Homo sapiens_hsa030221.15792727
38Sulfur relay system_Homo sapiens_hsa041221.15599771
39GABAergic synapse_Homo sapiens_hsa047271.15389341
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14351587
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10612709
42Pyrimidine metabolism_Homo sapiens_hsa002401.07812602
43Axon guidance_Homo sapiens_hsa043601.06777721
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05925516
45Salivary secretion_Homo sapiens_hsa049701.05750785
46Renin secretion_Homo sapiens_hsa049241.04566057
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.02983607
48Sulfur metabolism_Homo sapiens_hsa009201.02460096
49Oocyte meiosis_Homo sapiens_hsa041141.00832265
50Chemical carcinogenesis_Homo sapiens_hsa052040.95287708
51Ether lipid metabolism_Homo sapiens_hsa005650.94818397
52Tyrosine metabolism_Homo sapiens_hsa003500.91186606
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91024834
54Calcium signaling pathway_Homo sapiens_hsa040200.89533818
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89422084
56beta-Alanine metabolism_Homo sapiens_hsa004100.85657812
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84869496
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83605004
59Phenylalanine metabolism_Homo sapiens_hsa003600.82644994
60RNA transport_Homo sapiens_hsa030130.82550455
61Purine metabolism_Homo sapiens_hsa002300.81745432
62Cholinergic synapse_Homo sapiens_hsa047250.81009248
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79121300
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79079562
65Gastric acid secretion_Homo sapiens_hsa049710.79046451
66Nucleotide excision repair_Homo sapiens_hsa034200.79042950
67Propanoate metabolism_Homo sapiens_hsa006400.78824330
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78604709
69Rheumatoid arthritis_Homo sapiens_hsa053230.78586531
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77352769
71Sphingolipid metabolism_Homo sapiens_hsa006000.77314659
72Arginine and proline metabolism_Homo sapiens_hsa003300.77189633
73Gap junction_Homo sapiens_hsa045400.76568654
74Melanogenesis_Homo sapiens_hsa049160.76297697
75Oxytocin signaling pathway_Homo sapiens_hsa049210.75413144
76Alcoholism_Homo sapiens_hsa050340.72521108
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71402816
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70800495
79GnRH signaling pathway_Homo sapiens_hsa049120.69873842
80One carbon pool by folate_Homo sapiens_hsa006700.68896125
81Cocaine addiction_Homo sapiens_hsa050300.67184747
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66857684
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66568263
84Homologous recombination_Homo sapiens_hsa034400.65109531
85Hedgehog signaling pathway_Homo sapiens_hsa043400.64637733
86Peroxisome_Homo sapiens_hsa041460.63178168
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62726712
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.62136165
89Carbon metabolism_Homo sapiens_hsa012000.61819983
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61709438
91Steroid biosynthesis_Homo sapiens_hsa001000.61577202
92Biosynthesis of amino acids_Homo sapiens_hsa012300.60949705
93RNA degradation_Homo sapiens_hsa030180.59718046
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59378039
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59002306
96* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57536177
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54506461
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53793237
99Phagosome_Homo sapiens_hsa041450.53160933
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52345048
101Histidine metabolism_Homo sapiens_hsa003400.52103498
102Fatty acid elongation_Homo sapiens_hsa000620.51205824
103Wnt signaling pathway_Homo sapiens_hsa043100.50536036
104Mismatch repair_Homo sapiens_hsa034300.48271938
105Arachidonic acid metabolism_Homo sapiens_hsa005900.48065760
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46685657
107Butanoate metabolism_Homo sapiens_hsa006500.45172724
108Ras signaling pathway_Homo sapiens_hsa040140.44338447
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.43519499
110N-Glycan biosynthesis_Homo sapiens_hsa005100.42953362
111Non-homologous end-joining_Homo sapiens_hsa034500.41634710
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41352893
113Retinol metabolism_Homo sapiens_hsa008300.41130084
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41045061
115Linoleic acid metabolism_Homo sapiens_hsa005910.39937012
116Caffeine metabolism_Homo sapiens_hsa002320.39472807
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.39173541
118Tight junction_Homo sapiens_hsa045300.39100720
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38926290
120Epstein-Barr virus infection_Homo sapiens_hsa051690.38764463
121Insulin secretion_Homo sapiens_hsa049110.38195553
122cAMP signaling pathway_Homo sapiens_hsa040240.37712545
123Fanconi anemia pathway_Homo sapiens_hsa034600.37245571
124Estrogen signaling pathway_Homo sapiens_hsa049150.34973081
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34049249
126mRNA surveillance pathway_Homo sapiens_hsa030150.33855477
127DNA replication_Homo sapiens_hsa030300.33701795
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32807361
129Cell cycle_Homo sapiens_hsa041100.32798988
130Mineral absorption_Homo sapiens_hsa049780.32408387
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31555284
132Fatty acid degradation_Homo sapiens_hsa000710.31271703
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31250381
134Glioma_Homo sapiens_hsa052140.30867253
135Metabolic pathways_Homo sapiens_hsa011000.30643257
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29860704
137African trypanosomiasis_Homo sapiens_hsa051430.28288391
138Nitrogen metabolism_Homo sapiens_hsa009100.27163971
139Basal cell carcinoma_Homo sapiens_hsa052170.27113020
140Regulation of autophagy_Homo sapiens_hsa041400.27060781
141TGF-beta signaling pathway_Homo sapiens_hsa043500.26312274
142VEGF signaling pathway_Homo sapiens_hsa043700.26175016
143Hippo signaling pathway_Homo sapiens_hsa043900.25968840
144Renal cell carcinoma_Homo sapiens_hsa052110.25575143
145Fatty acid metabolism_Homo sapiens_hsa012120.25427606
146Pancreatic secretion_Homo sapiens_hsa049720.24900923
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24153073
148ErbB signaling pathway_Homo sapiens_hsa040120.23914272
149Choline metabolism in cancer_Homo sapiens_hsa052310.23867024

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