ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	8.91973016
2	epithelial cilium movement (GO:0003351)	8.50872466
3	cilium movement (GO:0003341)	7.62067890
4	neuron fate determination (GO:0048664)	6.76125633
5	axonemal dynein complex assembly (GO:0070286)	6.40025519
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.39054782
7	ATP synthesis coupled proton transport (GO:0015986)	5.65533221
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.65533221
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.46500991
10	behavioral response to nicotine (GO:0035095)	5.23295701
11	motile cilium assembly (GO:0044458)	5.17524938
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.08042991
13	intraciliary transport (GO:0042073)	5.06786679
14	cilium or flagellum-dependent cell motility (GO:0001539)	4.98787474
15	protein K6-linked ubiquitination (GO:0085020)	4.93286207
16	respiratory electron transport chain (GO:0022904)	4.78188938
17	electron transport chain (GO:0022900)	4.70921526
18	GTP biosynthetic process (GO:0006183)	4.59471848
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.48097432
20	nucleoside diphosphate phosphorylation (GO:0006165)	4.43336734
21	retinal cone cell development (GO:0046549)	4.22602345
22	chaperone-mediated protein transport (GO:0072321)	4.18963334
23	substrate-independent telencephalic tangential migration (GO:0021826)	4.17039062
24	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.17039062
25	UTP biosynthetic process (GO:0006228)	4.00427377
26	UTP metabolic process (GO:0046051)	3.86562954
27	neuron fate specification (GO:0048665)	3.82071451
28	centriole replication (GO:0007099)	3.79457631
29	microtubule polymerization or depolymerization (GO:0031109)	3.72489714
30	dopaminergic neuron differentiation (GO:0071542)	3.58471518
31	ribosomal small subunit assembly (GO:0000028)	3.55931187
32	axoneme assembly (GO:0035082)	3.54391602
33	viral transcription (GO:0019083)	3.52086896
34	ADP metabolic process (GO:0046031)	3.51879214
35	translational termination (GO:0006415)	3.51486362
36	protein neddylation (GO:0045116)	3.49321746
37	peptidyl-histidine modification (GO:0018202)	3.48658261
38	positive regulation of gastrulation (GO:2000543)	3.44840266
39	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.34828306
40	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.29929038
41	inner mitochondrial membrane organization (GO:0007007)	3.25399359
42	dentate gyrus development (GO:0021542)	3.23396755
43	CENP-A containing nucleosome assembly (GO:0034080)	3.23151125
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19799794
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19799794
46	NADH dehydrogenase complex assembly (GO:0010257)	3.19799794
47	cilium organization (GO:0044782)	3.15206783
48	protein localization to cilium (GO:0061512)	3.14261833
49	CTP metabolic process (GO:0046036)	3.13483307
50	CTP biosynthetic process (GO:0006241)	3.13483307
51	kinetochore assembly (GO:0051382)	3.12660866
52	cotranslational protein targeting to membrane (GO:0006613)	3.10896691
53	kinetochore organization (GO:0051383)	3.09754069
54	guanosine-containing compound biosynthetic process (GO:1901070)	3.08658615
55	chromatin remodeling at centromere (GO:0031055)	3.08202144
56	dendritic spine morphogenesis (GO:0060997)	3.07940772
57	spermatid nucleus differentiation (GO:0007289)	3.06416104
58	cilium morphogenesis (GO:0060271)	3.05976213
59	protein complex biogenesis (GO:0070271)	3.03781319
60	resolution of meiotic recombination intermediates (GO:0000712)	3.02994636
61	iron-sulfur cluster assembly (GO:0016226)	3.02838426
62	metallo-sulfur cluster assembly (GO:0031163)	3.02838426
63	cilium assembly (GO:0042384)	3.02836410
64	intracellular protein transmembrane import (GO:0044743)	3.02355211
65	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.02353974
66	retinal ganglion cell axon guidance (GO:0031290)	3.02260630
67	negative regulation of axon guidance (GO:1902668)	3.01719094
68	protein-cofactor linkage (GO:0018065)	3.01174562
69	nucleotide phosphorylation (GO:0046939)	2.98339960
70	nucleoside triphosphate biosynthetic process (GO:0009142)	2.98005343
71	ventricular system development (GO:0021591)	2.97720889
72	ATP biosynthetic process (GO:0006754)	2.95467188
73	translational elongation (GO:0006414)	2.94959860
74	centriole assembly (GO:0098534)	2.94730850
75	protein targeting to ER (GO:0045047)	2.94324151
76	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	2.91255070
77	hydrogen ion transmembrane transport (GO:1902600)	2.90365654
78	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.90158269
79	midbrain development (GO:0030901)	2.90150585
80	left/right pattern formation (GO:0060972)	2.89562950
81	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.84171640
82	microtubule depolymerization (GO:0007019)	2.83465172
83	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.81728478
84	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.80653890
85	thalamus development (GO:0021794)	2.79335806
86	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.78950552
87	organelle disassembly (GO:1903008)	2.77639707
88	vocalization behavior (GO:0071625)	2.77195442
89	determination of left/right symmetry (GO:0007368)	2.76597311
90	behavioral defense response (GO:0002209)	2.75160957
91	behavioral fear response (GO:0001662)	2.75160957
92	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.75128178
93	cellular protein complex disassembly (GO:0043624)	2.74134120
94	proton transport (GO:0015992)	2.71418404
95	transmission of nerve impulse (GO:0019226)	2.70782084
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.68989444
97	microtubule-based movement (GO:0007018)	2.67625100
98	hydrogen transport (GO:0006818)	2.66524792
99	protein localization to endoplasmic reticulum (GO:0070972)	2.64976627
100	cell proliferation in forebrain (GO:0021846)	2.62496572

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.34871123
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.54983864
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.33601656
4	VDR_22108803_ChIP-Seq_LS180_Human	3.00172558
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.75713278
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.68029169
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.63777106
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.59047621
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.56083519
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49769068
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47276901
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.46680062
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40705914
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.31551512
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.24586345
16	FUS_26573619_Chip-Seq_HEK293_Human	2.18626244
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.10237759
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04400884
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96286392
20	EWS_26573619_Chip-Seq_HEK293_Human	1.93327237
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89955804
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76984993
23	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.73050833
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.72386744
25	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.69473179
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69112972
27	P300_19829295_ChIP-Seq_ESCs_Human	1.64088603
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63112794
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62118596
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.58427407
31	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.56655000
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53008038
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52903532
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51386086
35	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.46329426
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45385996
37	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.43233453
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41799223
39	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.41357141
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.39465796
41	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39398813
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.37843759
43	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.36208500
44	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.33010669
45	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.32465413
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32094635
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.31865465
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31351117
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.30350376
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.30283832
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.27466749
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.26260868
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24985797
54	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24932896
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23617739
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23617739
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.21834830
58	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.20291996
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.19498966
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18420837
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18420837
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18163012
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.17940307
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.09762112
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08594525
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08142401
67	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.06327877
68	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.06327877
69	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.06327877
70	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05926426
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05328991
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05277871
73	XRN2_22483619_ChIP-Seq_HELA_Human	1.03255613
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03116878
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.02917281
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02917281
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02522709
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.01980960
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01743937
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.01525657
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01338014
82	SMAD4_21799915_ChIP-Seq_A2780_Human	0.99157320
83	VDR_23849224_ChIP-Seq_CD4+_Human	0.97914023
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96248631
85	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.96223774
86	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95674346
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95453617
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95453617
89	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.93030278
90	TBL1_22424771_ChIP-Seq_293T_Human	0.92759819
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91916389
92	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.91489034
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91325596
94	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.90947362
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90670999
96	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.89332951
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.89116450
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.88549288
99	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.88549288
100	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.88355349

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	5.61112591
2	MP0003283_abnormal_digestive_organ	3.34982291
3	MP0002653_abnormal_ependyma_morphology	3.18279513
4	MP0009379_abnormal_foot_pigmentation	3.00443278
5	MP0010030_abnormal_orbit_morphology	2.98150706
6	MP0003880_abnormal_central_pattern	2.87344999
7	MP0005645_abnormal_hypothalamus_physiol	2.68620014
8	MP0002938_white_spotting	2.55158777
9	MP0002102_abnormal_ear_morphology	2.52433366
10	MP0000372_irregular_coat_pigmentation	2.45071012
11	MP0006292_abnormal_olfactory_placode	2.41776309
12	MP0006276_abnormal_autonomic_nervous	2.37835931
13	MP0002638_abnormal_pupillary_reflex	2.37126038
14	MP0008789_abnormal_olfactory_epithelium	2.27772501
15	MP0003136_yellow_coat_color	2.24520187
16	MP0001529_abnormal_vocalization	2.24012777
17	MP0003122_maternal_imprinting	2.13146212
18	MP0003938_abnormal_ear_development	1.92581660
19	MP0003806_abnormal_nucleotide_metabolis	1.88951219
20	MP0004133_heterotaxia	1.87796457
21	MP0005499_abnormal_olfactory_system	1.86325841
22	MP0005394_taste/olfaction_phenotype	1.86325841
23	MP0010386_abnormal_urinary_bladder	1.78061525
24	MP0003121_genomic_imprinting	1.74104603
25	MP0000778_abnormal_nervous_system	1.71443047
26	MP0003123_paternal_imprinting	1.66212826
27	MP0002928_abnormal_bile_duct	1.61346047
28	MP0004142_abnormal_muscle_tone	1.59073376
29	MP0001293_anophthalmia	1.58877604
30	MP0002277_abnormal_respiratory_mucosa	1.56848407
31	MP0002272_abnormal_nervous_system	1.55125068
32	MP0005187_abnormal_penis_morphology	1.52041568
33	MP0000026_abnormal_inner_ear	1.35563945
34	MP0001485_abnormal_pinna_reflex	1.35095258
35	MP0002734_abnormal_mechanical_nocicepti	1.34013858
36	MP0000579_abnormal_nail_morphology	1.33919920
37	MP0004742_abnormal_vestibular_system	1.33416683
38	MP0009046_muscle_twitch	1.28622490
39	MP0005084_abnormal_gallbladder_morpholo	1.27698055
40	MP0006072_abnormal_retinal_apoptosis	1.25533336
41	MP0002282_abnormal_trachea_morphology	1.24191740
42	MP0000631_abnormal_neuroendocrine_gland	1.23754337
43	MP0009745_abnormal_behavioral_response	1.19079572
44	MP0001286_abnormal_eye_development	1.17994085
45	MP0003890_abnormal_embryonic-extraembry	1.15819992
46	MP0003315_abnormal_perineum_morphology	1.15795948
47	MP0005257_abnormal_intraocular_pressure	1.12240674
48	MP0004019_abnormal_vitamin_homeostasis	1.11609452
49	MP0001984_abnormal_olfaction	1.10488755
50	MP0004885_abnormal_endolymph	1.10279340
51	MP0003942_abnormal_urinary_system	1.09907400
52	MP0005171_absent_coat_pigmentation	1.09115366
53	MP0002210_abnormal_sex_determination	1.07377256
54	MP0008961_abnormal_basal_metabolism	1.06206303
55	MP0003787_abnormal_imprinting	1.06114057
56	MP0001188_hyperpigmentation	1.04745395
57	MP0002160_abnormal_reproductive_system	1.04640502
58	MP0002557_abnormal_social/conspecific_i	1.04504421
59	MP0005551_abnormal_eye_electrophysiolog	1.04226014
60	MP0005423_abnormal_somatic_nervous	1.01815811
61	MP0001542_abnormal_bone_strength	1.01581974
62	MP0000749_muscle_degeneration	1.00138315
63	MP0004145_abnormal_muscle_electrophysio	0.99570366
64	MP0008877_abnormal_DNA_methylation	0.97735806
65	MP0002064_seizures	0.96493974
66	MP0002752_abnormal_somatic_nervous	0.95589736
67	MP0004270_analgesia	0.95325897
68	MP0000537_abnormal_urethra_morphology	0.95270398
69	MP0000647_abnormal_sebaceous_gland	0.94204442
70	MP0005253_abnormal_eye_physiology	0.94098400
71	MP0003937_abnormal_limbs/digits/tail_de	0.94090275
72	MP0005195_abnormal_posterior_eye	0.93088680
73	MP0002138_abnormal_hepatobiliary_system	0.91154542
74	MP0002822_catalepsy	0.89486912
75	MP0000049_abnormal_middle_ear	0.87790446
76	MP0002184_abnormal_innervation	0.85391039
77	MP0000955_abnormal_spinal_cord	0.84419611
78	MP0003959_abnormal_lean_body	0.84396298
79	MP0000653_abnormal_sex_gland	0.83091681
80	MP0002751_abnormal_autonomic_nervous	0.82906388
81	MP0002697_abnormal_eye_size	0.82586484
82	MP0001486_abnormal_startle_reflex	0.81778969
83	MP0002882_abnormal_neuron_morphology	0.80814621
84	MP0001970_abnormal_pain_threshold	0.80802359
85	MP0002572_abnormal_emotion/affect_behav	0.80636624
86	MP0002233_abnormal_nose_morphology	0.79949577
87	MP0005448_abnormal_energy_balance	0.79592079
88	MP0002067_abnormal_sensory_capabilities	0.78131198
89	MP0005389_reproductive_system_phenotype	0.76652588
90	MP0001145_abnormal_male_reproductive	0.76549185
91	MP0003635_abnormal_synaptic_transmissio	0.76211413
92	MP0005266_abnormal_metabolism	0.75588051
93	MP0001963_abnormal_hearing_physiology	0.74417062
94	MP0003698_abnormal_male_reproductive	0.73946745
95	MP0002234_abnormal_pharynx_morphology	0.73764936
96	MP0003011_delayed_dark_adaptation	0.72054965
97	MP0001929_abnormal_gametogenesis	0.70797569
98	MP0001324_abnormal_eye_pigmentation	0.70030828
99	MP0002095_abnormal_skin_pigmentation	0.69676907
100	MP0002909_abnormal_adrenal_gland	0.67616786

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	7.04881760
2	Absent/shortened dynein arms (HP:0200106)	6.84023319
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.84023319
4	Abnormal respiratory motile cilium physiology (HP:0012261)	6.38579371
5	Abnormal respiratory epithelium morphology (HP:0012253)	6.05506718
6	Abnormal respiratory motile cilium morphology (HP:0005938)	6.05506718
7	Rhinitis (HP:0012384)	4.92145606
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.46210761
9	Increased hepatocellular lipid droplets (HP:0006565)	4.15200360
10	Lipid accumulation in hepatocytes (HP:0006561)	3.64869027
11	Chronic otitis media (HP:0000389)	3.62692249
12	Chronic sinusitis (HP:0011109)	3.60006404
13	Septo-optic dysplasia (HP:0100842)	3.59747806
14	Mitochondrial inheritance (HP:0001427)	3.57699374
15	Acute necrotizing encephalopathy (HP:0006965)	3.48755071
16	Abnormality of midbrain morphology (HP:0002418)	3.43845855
17	Molar tooth sign on MRI (HP:0002419)	3.43845855
18	Medial flaring of the eyebrow (HP:0010747)	3.19924217
19	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11564935
20	Renal Fanconi syndrome (HP:0001994)	3.11149432
21	Increased CSF lactate (HP:0002490)	3.04605417
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.98754226
23	Nephronophthisis (HP:0000090)	2.96887595
24	3-Methylglutaconic aciduria (HP:0003535)	2.96395643
25	Retinal dysplasia (HP:0007973)	2.94145775
26	Bronchiectasis (HP:0002110)	2.92934697
27	Acute encephalopathy (HP:0006846)	2.89143534
28	Exertional dyspnea (HP:0002875)	2.78834413
29	Progressive macrocephaly (HP:0004481)	2.77782339
30	Myokymia (HP:0002411)	2.75096182
31	Muscle fiber splitting (HP:0003555)	2.73972715
32	Pancreatic fibrosis (HP:0100732)	2.69909366
33	Chronic hepatic failure (HP:0100626)	2.68179881
34	Short nail (HP:0001799)	2.66009393
35	True hermaphroditism (HP:0010459)	2.65516911
36	Absent septum pellucidum (HP:0001331)	2.63721575
37	Abnormality of the labia minora (HP:0012880)	2.63694404
38	Tubular atrophy (HP:0000092)	2.60115319
39	Reticulocytopenia (HP:0001896)	2.56016356
40	Chronic bronchitis (HP:0004469)	2.52422508
41	Increased intramyocellular lipid droplets (HP:0012240)	2.52308083
42	Tubulointerstitial fibrosis (HP:0005576)	2.51944505
43	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.46717338
44	Concave nail (HP:0001598)	2.46369859
45	Abnormal number of erythroid precursors (HP:0012131)	2.38220379
46	Congenital hepatic fibrosis (HP:0002612)	2.37531331
47	Rib fusion (HP:0000902)	2.36182365
48	Focal motor seizures (HP:0011153)	2.33588324
49	Pancreatic cysts (HP:0001737)	2.33024131
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.30648434
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.30648434
52	Congenital, generalized hypertrichosis (HP:0004540)	2.29007362
53	Gait imbalance (HP:0002141)	2.26298520
54	Abnormality of abdominal situs (HP:0011620)	2.24759894
55	Abdominal situs inversus (HP:0003363)	2.24759894
56	Hepatocellular necrosis (HP:0001404)	2.24219457
57	Congenital primary aphakia (HP:0007707)	2.21592734
58	Respiratory difficulties (HP:0002880)	2.21420163
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.21365969
60	Male pseudohermaphroditism (HP:0000037)	2.20065684
61	Nonprogressive disorder (HP:0003680)	2.15867293
62	Abnormality of renal resorption (HP:0011038)	2.15157527
63	Abnormality of the renal medulla (HP:0100957)	2.11101924
64	Abnormality of cells of the erythroid lineage (HP:0012130)	2.10255028
65	Genital tract atresia (HP:0001827)	2.09864899
66	Respiratory failure (HP:0002878)	2.09788195
67	Vaginal atresia (HP:0000148)	2.09535707
68	Agitation (HP:0000713)	2.07023287
69	Tubulointerstitial abnormality (HP:0001969)	2.06463911
70	Esophageal atresia (HP:0002032)	2.04896441
71	Hepatic necrosis (HP:0002605)	2.02424211
72	Optic disc pallor (HP:0000543)	2.01680780
73	Sclerocornea (HP:0000647)	2.01591241
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00439408
75	Exercise intolerance (HP:0003546)	1.96487943
76	Nasal polyposis (HP:0100582)	1.96273068
77	Sleep apnea (HP:0010535)	1.95994972
78	Increased muscle lipid content (HP:0009058)	1.95087698
79	Nephrogenic diabetes insipidus (HP:0009806)	1.91840148
80	Abnormality of the septum pellucidum (HP:0007375)	1.91774704
81	Hyperphosphaturia (HP:0003109)	1.91254522
82	Bifid scrotum (HP:0000048)	1.91231390
83	Occipital encephalocele (HP:0002085)	1.87132434
84	Type II lissencephaly (HP:0007260)	1.86881446
85	Delayed gross motor development (HP:0002194)	1.85177463
86	Anencephaly (HP:0002323)	1.83493700
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.83381598
88	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.83057072
89	Hypoplasia of the brainstem (HP:0002365)	1.83057072
90	Anophthalmia (HP:0000528)	1.79578505
91	Hyperphosphatemia (HP:0002905)	1.78137534
92	Cerebral edema (HP:0002181)	1.76588372
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76370962
94	Polydipsia (HP:0001959)	1.73203946
95	Abnormal drinking behavior (HP:0030082)	1.73203946
96	Broad distal phalanx of finger (HP:0009836)	1.70804599
97	Cystic liver disease (HP:0006706)	1.70674398
98	Maternal diabetes (HP:0009800)	1.70642078
99	Aganglionic megacolon (HP:0002251)	1.70149732
100	Leukodystrophy (HP:0002415)	1.67165273

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	3.73449815
2	STK16	3.65676534
3	CCNB1	3.53587962
4	MAPK15	2.78582619
5	TLK1	2.63883883
6	ZAK	2.30925952
7	MINK1	2.13650361
8	MAP3K4	2.13579873
9	EPHB2	2.12354348
10	VRK2	2.06091730
11	NUAK1	1.92985874
12	EPHA4	1.92335692
13	WNK3	1.83448935
14	BMPR1B	1.79943406
15	PASK	1.73955202
16	MAP4K2	1.72714663
17	DYRK3	1.70300915
18	FGFR2	1.67565390
19	MAP2K7	1.65836219
20	TNIK	1.64296798
21	VRK1	1.56534842
22	MUSK	1.54643631
23	PKN2	1.54060962
24	MARK1	1.47197767
25	STK38L	1.45004473
26	TTK	1.44959915
27	CAMKK2	1.39180582
28	DMPK	1.37886004
29	AURKA	1.32214150
30	WEE1	1.31930769
31	CSNK1G2	1.31776656
32	DYRK2	1.28059340
33	PKN1	1.25982816
34	UHMK1	1.24876575
35	SRPK1	1.21886572
36	MKNK1	1.21470341
37	WNK4	1.21091111
38	PHKG2	1.20332737
39	PHKG1	1.20332737
40	PRKCG	1.19984872
41	ADRBK2	1.16409462
42	NTRK2	1.15793611
43	CASK	1.13505301
44	EPHA3	1.12303253
45	CSNK1G3	1.08158169
46	MAP2K4	1.07903600
47	STK39	1.07101257
48	CSNK1G1	1.07090008
49	CAMKK1	1.00885177
50	MKNK2	0.99473943
51	MAPK13	0.99147546
52	PAK3	0.96373355
53	PLK3	0.96373184
54	PTK2B	0.95359879
55	PINK1	0.94169051
56	NME2	0.92420098
57	RPS6KA4	0.89090918
58	CSNK1A1L	0.88576041
59	PLK1	0.87514370
60	MAP3K12	0.86575969
61	BRSK1	0.83270809
62	PNCK	0.82479745
63	TYRO3	0.80974573
64	STK3	0.76273056
65	PRKG1	0.71343322
66	TRIM28	0.70107658
67	STK24	0.67032364
68	GRK1	0.66782931
69	NME1	0.66351245
70	INSRR	0.66235946
71	OBSCN	0.62141731
72	AKT2	0.60907134
73	DYRK1B	0.59829479
74	CDK8	0.59152914
75	MAPKAPK3	0.53124626
76	GRK7	0.52167778
77	FLT3	0.51904667
78	ADRBK1	0.50732235
79	AURKB	0.49094027
80	EIF2AK2	0.47990318
81	LATS1	0.47005307
82	FGFR1	0.46002917
83	CHEK2	0.43644888
84	OXSR1	0.41953496
85	FRK	0.41275735
86	PRKACA	0.41228932
87	MAPKAPK2	0.37330411
88	MOS	0.36756121
89	CDK14	0.36419702
90	NEK2	0.36174037
91	TGFBR1	0.35648655
92	CSNK2A1	0.35328487
93	MAP3K11	0.32956150
94	CSNK2A2	0.32781473
95	PRKCH	0.29716604
96	MAP2K6	0.29523728
97	RPS6KA5	0.29272342
98	CSNK1A1	0.29097536
99	GSK3A	0.28779973
100	NTRK3	0.28496497

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.66425818
2	Parkinsons disease_Homo sapiens_hsa05012	4.70231202
3	Huntingtons disease_Homo sapiens_hsa05016	3.86267086
4	Ribosome_Homo sapiens_hsa03010	3.53963103
5	Alzheimers disease_Homo sapiens_hsa05010	3.40365893
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.17874929
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.80537810
8	Proteasome_Homo sapiens_hsa03050	2.75215940
9	Protein export_Homo sapiens_hsa03060	2.55407209
10	Folate biosynthesis_Homo sapiens_hsa00790	2.02420070
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94403954
12	Nicotine addiction_Homo sapiens_hsa05033	1.85625571
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80726061
14	RNA polymerase_Homo sapiens_hsa03020	1.79148691
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61010013
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41977719
17	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40779169
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.31129994
19	Phototransduction_Homo sapiens_hsa04744	1.25445021
20	Cocaine addiction_Homo sapiens_hsa05030	1.22444001
21	Purine metabolism_Homo sapiens_hsa00230	1.21624050
22	Spliceosome_Homo sapiens_hsa03040	1.20047916
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.19766825
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18801838
25	Base excision repair_Homo sapiens_hsa03410	1.16317422
26	Butanoate metabolism_Homo sapiens_hsa00650	1.16221261
27	Oocyte meiosis_Homo sapiens_hsa04114	1.08120807
28	Histidine metabolism_Homo sapiens_hsa00340	1.03610335
29	Cell cycle_Homo sapiens_hsa04110	1.03161735
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00741037
31	Gap junction_Homo sapiens_hsa04540	0.96567190
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95036626
33	Mismatch repair_Homo sapiens_hsa03430	0.93442930
34	Morphine addiction_Homo sapiens_hsa05032	0.91999065
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91338480
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90886409
37	Olfactory transduction_Homo sapiens_hsa04740	0.89571201
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87660152
39	Homologous recombination_Homo sapiens_hsa03440	0.85842363
40	Steroid biosynthesis_Homo sapiens_hsa00100	0.85750111
41	Basal transcription factors_Homo sapiens_hsa03022	0.84427609
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83549547
43	GABAergic synapse_Homo sapiens_hsa04727	0.83314178
44	Glutathione metabolism_Homo sapiens_hsa00480	0.82497309
45	Basal cell carcinoma_Homo sapiens_hsa05217	0.79535258
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.79357730
47	p53 signaling pathway_Homo sapiens_hsa04115	0.76503299
48	DNA replication_Homo sapiens_hsa03030	0.75734343
49	Metabolic pathways_Homo sapiens_hsa01100	0.75301964
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71266486
51	Axon guidance_Homo sapiens_hsa04360	0.71183231
52	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.70421712
53	RNA degradation_Homo sapiens_hsa03018	0.69998558
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.68752926
55	Salivary secretion_Homo sapiens_hsa04970	0.68081742
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65802118
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62982551
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61351559
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.59995752
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.59663982
61	Peroxisome_Homo sapiens_hsa04146	0.56540131
62	Insulin secretion_Homo sapiens_hsa04911	0.56387957
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56272588
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56144353
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55747380
66	Serotonergic synapse_Homo sapiens_hsa04726	0.54230737
67	Circadian entrainment_Homo sapiens_hsa04713	0.53767158
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.53683393
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51799522
70	Amphetamine addiction_Homo sapiens_hsa05031	0.50889411
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.50567855
72	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49970394
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48512224
74	Regulation of autophagy_Homo sapiens_hsa04140	0.48391249
75	Taste transduction_Homo sapiens_hsa04742	0.46617023
76	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45945693
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44685155
78	Fatty acid elongation_Homo sapiens_hsa00062	0.44612868
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43057424
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42723575
81	Alcoholism_Homo sapiens_hsa05034	0.41629766
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.38514347
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36967788
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.36203687
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35807379
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.35459287
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35175960
88	Cholinergic synapse_Homo sapiens_hsa04725	0.33889244
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32905449
90	Asthma_Homo sapiens_hsa05310	0.32120045
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31804450
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.30183175
93	Sulfur relay system_Homo sapiens_hsa04122	0.29034782
94	Linoleic acid metabolism_Homo sapiens_hsa00591	0.28744134
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28084543
96	One carbon pool by folate_Homo sapiens_hsa00670	0.28015792
97	Renin secretion_Homo sapiens_hsa04924	0.27625649
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27343978
99	Retinol metabolism_Homo sapiens_hsa00830	0.27306959
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.25938477

DYNLL1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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