DYNLRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.66353052
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.19327823
3ATP synthesis coupled proton transport (GO:0015986)7.19327823
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.03477852
5respiratory electron transport chain (GO:0022904)6.05314365
6electron transport chain (GO:0022900)5.91845482
7chaperone-mediated protein transport (GO:0072321)5.66649733
8protein neddylation (GO:0045116)5.62796135
9protein complex biogenesis (GO:0070271)4.35678096
10sequestering of actin monomers (GO:0042989)4.22856092
11neuron cell-cell adhesion (GO:0007158)4.09826013
12hydrogen ion transmembrane transport (GO:1902600)4.05740026
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.03170329
14NADH dehydrogenase complex assembly (GO:0010257)4.03170329
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03170329
16protein maturation by protein folding (GO:0022417)3.92795920
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.88654365
18long-chain fatty acid biosynthetic process (GO:0042759)3.86388219
19energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.83850737
20ATP hydrolysis coupled proton transport (GO:0015991)3.83850737
21mitochondrial respiratory chain complex assembly (GO:0033108)3.79735228
22fatty acid elongation (GO:0030497)3.67055734
23synaptic vesicle exocytosis (GO:0016079)3.65025044
24proton transport (GO:0015992)3.64638816
25presynaptic membrane assembly (GO:0097105)3.62172174
26ATP biosynthetic process (GO:0006754)3.60328511
27glutamate secretion (GO:0014047)3.57821854
28hydrogen transport (GO:0006818)3.56024107
29synaptic vesicle maturation (GO:0016188)3.52124307
30purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43777135
31transferrin transport (GO:0033572)3.42154155
32cullin deneddylation (GO:0010388)3.38750484
33proteasome assembly (GO:0043248)3.37223765
34presynaptic membrane organization (GO:0097090)3.36641403
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35631399
36substantia nigra development (GO:0021762)3.27700553
37dopamine transport (GO:0015872)3.23006305
38central nervous system myelination (GO:0022010)3.22586239
39axon ensheathment in central nervous system (GO:0032291)3.22586239
40ferric iron transport (GO:0015682)3.15238151
41trivalent inorganic cation transport (GO:0072512)3.15238151
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14464530
43inner mitochondrial membrane organization (GO:0007007)3.13093402
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.12551119
45substrate-independent telencephalic tangential migration (GO:0021826)3.12551119
46protein deneddylation (GO:0000338)3.11921515
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.11103288
48negative regulation of response to food (GO:0032096)3.10389049
49negative regulation of appetite (GO:0032099)3.10389049
50respiratory chain complex IV assembly (GO:0008535)3.10175876
51regulation of catecholamine metabolic process (GO:0042069)3.08658387
52regulation of dopamine metabolic process (GO:0042053)3.08658387
53positive regulation of neurotransmitter transport (GO:0051590)3.01419348
54regulation of synapse structural plasticity (GO:0051823)3.00185282
55regulation of autophagic vacuole assembly (GO:2000785)2.99669346
56cytochrome complex assembly (GO:0017004)2.96316730
57phagosome maturation (GO:0090382)2.91803238
58ribonucleoside triphosphate biosynthetic process (GO:0009201)2.90631157
59neuronal action potential propagation (GO:0019227)2.89891295
60dopamine biosynthetic process (GO:0042416)2.86887010
61GTP biosynthetic process (GO:0006183)2.85847316
62regulation of protein kinase A signaling (GO:0010738)2.85829786
63regulation of glutamate secretion (GO:0014048)2.84560215
64calcium-mediated signaling using intracellular calcium source (GO:0035584)2.83613035
65regulation of cilium movement (GO:0003352)2.82099572
66protein targeting to mitochondrion (GO:0006626)2.81902283
67positive regulation of synapse assembly (GO:0051965)2.79269020
68establishment of protein localization to mitochondrion (GO:0072655)2.78859454
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77822222
70protein localization to synapse (GO:0035418)2.77687955
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76386388
72L-phenylalanine metabolic process (GO:0006558)2.76386388
73positive regulation of neurotransmitter secretion (GO:0001956)2.74065080
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72864522
75L-phenylalanine catabolic process (GO:0006559)2.72864522
76vocalization behavior (GO:0071625)2.71831189
77protein insertion into membrane (GO:0051205)2.71793283
78negative regulation of microtubule polymerization (GO:0031115)2.71330197
79platelet dense granule organization (GO:0060155)2.70726664
80regulation of vacuole organization (GO:0044088)2.70408560
81response to misfolded protein (GO:0051788)2.70018061
82dendritic spine morphogenesis (GO:0060997)2.69902906
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69523137
84positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.68776717
85positive regulation of TOR signaling (GO:0032008)2.67845894
86viral protein processing (GO:0019082)2.66289746
87negative regulation of calcium ion transmembrane transport (GO:1903170)2.66190367
88negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.66190367
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65235833
90cerebellar Purkinje cell layer development (GO:0021680)2.64603506
91mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63670070
92regulation of cellular amino acid metabolic process (GO:0006521)2.63283523
93negative regulation of neurotransmitter transport (GO:0051589)2.62807421
94protein localization to cilium (GO:0061512)2.62648713
95regulation of microtubule-based movement (GO:0060632)2.61914532
96protein localization to mitochondrion (GO:0070585)2.61610994
97neurotransmitter secretion (GO:0007269)2.61338567
98regulation of vesicle fusion (GO:0031338)2.61140562
99postsynaptic membrane organization (GO:0001941)2.60857839
100positive regulation of action potential (GO:0045760)2.60678163
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.59025830
102neurotransmitter uptake (GO:0001504)2.58509213
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58279976
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57660891
105oxidative phosphorylation (GO:0006119)2.57323180
106response to redox state (GO:0051775)2.57085789
107neuron recognition (GO:0008038)2.56788395
108viral transcription (GO:0019083)2.56381145
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.55991534
110membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55713363
111transmission of nerve impulse (GO:0019226)2.55321049
112neurofilament cytoskeleton organization (GO:0060052)2.52516516
113positive regulation of mitochondrial fission (GO:0090141)2.52022020
114regulation of synaptic vesicle exocytosis (GO:2000300)2.51841581
115response to gravity (GO:0009629)2.51241365
116synaptic transmission, glutamatergic (GO:0035249)2.50717825
117synaptic transmission, dopaminergic (GO:0001963)2.49119375
118regulation of oxidative phosphorylation (GO:0002082)2.48952075
119nucleoside triphosphate biosynthetic process (GO:0009142)2.48898929
120protein localization to endoplasmic reticulum (GO:0070972)2.48767092
121negative regulation of heart rate (GO:0010459)2.48755451
122virion assembly (GO:0019068)2.48043823
123protein targeting to ER (GO:0045047)2.47677725
124membrane assembly (GO:0071709)2.47106416
125cotranslational protein targeting to membrane (GO:0006613)2.46796977
126regulation of integrin-mediated signaling pathway (GO:2001044)2.45979786
127cellular potassium ion homeostasis (GO:0030007)2.43299838
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.43058029
129positive regulation of actin filament depolymerization (GO:0030836)2.43042512
130mitochondrial transport (GO:0006839)2.39991554
131catecholamine transport (GO:0051937)2.39462132
132behavioral response to cocaine (GO:0048148)2.38433145
133neural nucleus development (GO:0048857)2.38387250
134establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37354103
135translational termination (GO:0006415)2.37177906
136mannosylation (GO:0097502)2.35208851
137regulation of mitochondrial translation (GO:0070129)2.34923684
138response to cocaine (GO:0042220)2.34868163
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34062985
140regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.31728953
141regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.31728953
142synaptic vesicle transport (GO:0048489)2.31333381
143establishment of synaptic vesicle localization (GO:0097480)2.31333381
144regulation of cellular amine metabolic process (GO:0033238)2.31247457
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.30569467
146neuron-neuron synaptic transmission (GO:0007270)2.27729817
147regulation of cellular respiration (GO:0043457)2.27174804
148anterograde synaptic vesicle transport (GO:0048490)2.22528736
149negative regulation of cation channel activity (GO:2001258)2.21855731
150positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.21071560
151regulation of synaptic vesicle transport (GO:1902803)2.20440076
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.20383412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.37045573
2EZH2_22144423_ChIP-Seq_EOC_Human4.39109016
3GBX2_23144817_ChIP-Seq_PC3_Human3.44084746
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12428081
5TAF15_26573619_Chip-Seq_HEK293_Human2.88120465
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.83879736
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78769018
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64401195
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53769584
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47781579
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.44851612
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36840936
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.36104953
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30336183
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.24492740
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22245101
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21296376
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20594672
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18959492
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16144261
21VDR_22108803_ChIP-Seq_LS180_Human2.14998835
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11082694
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.08954160
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02907689
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02907689
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99466462
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97022199
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92834926
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91102820
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86349403
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.85216329
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83956425
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.82393774
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81144537
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80569517
36* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77365306
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75911683
38P300_19829295_ChIP-Seq_ESCs_Human1.75340076
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72788773
40REST_21632747_ChIP-Seq_MESCs_Mouse1.71564972
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.71559381
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71480964
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70583816
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68291821
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66037057
46FUS_26573619_Chip-Seq_HEK293_Human1.62648839
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.59789598
48ER_23166858_ChIP-Seq_MCF-7_Human1.57940924
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.53520674
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53134692
51IGF1R_20145208_ChIP-Seq_DFB_Human1.52683105
52RNF2_27304074_Chip-Seq_NSC_Mouse1.51949847
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49422841
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.49144751
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.48479542
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45337094
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44913219
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.42946134
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42282189
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.42062726
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.42055670
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41705993
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40518261
64AR_21572438_ChIP-Seq_LNCaP_Human1.39173148
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39166407
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38363692
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38265042
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37612533
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36745115
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35010717
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32528393
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29630911
73JUN_21703547_ChIP-Seq_K562_Human1.29005203
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28589863
75CTCF_27219007_Chip-Seq_Bcells_Human1.27936877
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25834331
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.25815765
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24569005
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23845016
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.22710574
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.22369635
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20716889
83* LXR_22292898_ChIP-Seq_THP-1_Human1.20199179
84SMAD4_21799915_ChIP-Seq_A2780_Human1.20127875
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19500281
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.17878625
87CTCF_20526341_ChIP-Seq_ESCs_Human1.16984653
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16033612
89ZNF263_19887448_ChIP-Seq_K562_Human1.16018140
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15590381
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15276809
92SRF_21415370_ChIP-Seq_HL-1_Mouse1.13005506
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12052921
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.11405774
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10883155
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10782537
97XRN2_22483619_ChIP-Seq_HELA_Human1.10318395
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10142463
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09582692
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09538129
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09398051
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08699213
103RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08557846
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.08046876
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.07694184
106EWS_26573619_Chip-Seq_HEK293_Human1.07597410
107P68_20966046_ChIP-Seq_HELA_Human1.06980411
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06224963
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05486269
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04974194
111BCL6_27268052_Chip-Seq_Bcells_Human1.03929871
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03452732
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03138730
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.02178499
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01345554
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.00871291
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00131418
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99972862
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99625642
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99139598
121BP1_19119308_ChIP-ChIP_Hs578T_Human0.97180553
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96482209
123TP53_18474530_ChIP-ChIP_U2OS_Human0.96078532
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.95702205
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94903775
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94860805
127HTT_18923047_ChIP-ChIP_STHdh_Human0.94363110
128AR_25329375_ChIP-Seq_VCAP_Human0.94159528
129REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93289898
130* GABP_19822575_ChIP-Seq_HepG2_Human0.92693225
131STAT1_20625510_ChIP-Seq_HELA_Human0.92037764
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91583669
133MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90897149
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90484630
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.90430001
136SA1_27219007_Chip-Seq_Bcells_Human0.90232388
137* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90102569
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89184092
139SOX2_21211035_ChIP-Seq_LN229_Human0.88362515
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87904954
141IRF1_19129219_ChIP-ChIP_H3396_Human0.87877993
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.87797563
143NANOG_19829295_ChIP-Seq_ESCs_Human0.87729910
144SOX2_19829295_ChIP-Seq_ESCs_Human0.87729910
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87600022
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86749118
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86411284
148ZNF274_21170338_ChIP-Seq_K562_Hela0.86391201
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86239464
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86201688
151NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85660556
152RUNX2_22187159_ChIP-Seq_PCA_Human0.85249041
153TET1_21490601_ChIP-Seq_MESCs_Mouse0.85157871
154YY1_21170310_ChIP-Seq_MESCs_Mouse0.82546876
155E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82500481
156BCOR_27268052_Chip-Seq_Bcells_Human0.82209540
157* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81732472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.87108337
2MP0001529_abnormal_vocalization3.85548448
3MP0006276_abnormal_autonomic_nervous3.43152127
4MP0001905_abnormal_dopamine_level3.12385656
5MP0003123_paternal_imprinting2.83617850
6MP0001968_abnormal_touch/_nociception2.74566099
7MP0004270_analgesia2.61682971
8MP0002736_abnormal_nociception_after2.57706889
9MP0002734_abnormal_mechanical_nocicepti2.54864198
10MP0009046_muscle_twitch2.54564116
11MP0003635_abnormal_synaptic_transmissio2.54382542
12MP0002064_seizures2.53444566
13MP0009745_abnormal_behavioral_response2.49222950
14MP0001984_abnormal_olfaction2.46451361
15MP0002272_abnormal_nervous_system2.45104509
16MP0002735_abnormal_chemical_nociception2.38013628
17MP0004859_abnormal_synaptic_plasticity2.37963464
18MP0002653_abnormal_ependyma_morphology2.31104653
19MP0004142_abnormal_muscle_tone2.30473561
20MP0002572_abnormal_emotion/affect_behav2.20005335
21MP0009780_abnormal_chondrocyte_physiolo2.19924583
22MP0010386_abnormal_urinary_bladder2.13360663
23MP0005423_abnormal_somatic_nervous2.11893637
24MP0002063_abnormal_learning/memory/cond2.07881219
25MP0001970_abnormal_pain_threshold2.05007291
26MP0001440_abnormal_grooming_behavior1.99465289
27MP0002733_abnormal_thermal_nociception1.97416008
28MP0001501_abnormal_sleep_pattern1.96823856
29MP0009379_abnormal_foot_pigmentation1.96185083
30MP0001188_hyperpigmentation1.91973120
31MP0003122_maternal_imprinting1.87531006
32MP0001486_abnormal_startle_reflex1.84765250
33MP0002837_dystrophic_cardiac_calcinosis1.81906334
34MP0002822_catalepsy1.77581951
35MP0002184_abnormal_innervation1.77499267
36MP0000778_abnormal_nervous_system1.76280727
37MP0003186_abnormal_redox_activity1.75061273
38MP0002067_abnormal_sensory_capabilities1.74777207
39MP0002909_abnormal_adrenal_gland1.74192948
40MP0004924_abnormal_behavior1.65900005
41MP0005386_behavior/neurological_phenoty1.65900005
42MP0005171_absent_coat_pigmentation1.63817724
43MP0005645_abnormal_hypothalamus_physiol1.62463508
44MP0005464_abnormal_platelet_physiology1.48989858
45MP0001986_abnormal_taste_sensitivity1.47872564
46MP0000920_abnormal_myelination1.47557474
47MP0002638_abnormal_pupillary_reflex1.45393959
48MP0004742_abnormal_vestibular_system1.42908228
49MP0003011_delayed_dark_adaptation1.42779762
50MP0005058_abnormal_lysosome_morphology1.42487169
51MP0000372_irregular_coat_pigmentation1.35437708
52MP0005409_darkened_coat_color1.35029264
53MP0002557_abnormal_social/conspecific_i1.34405960
54MP0004510_myositis1.30030611
55MP0005646_abnormal_pituitary_gland1.29400338
56MP0005551_abnormal_eye_electrophysiolog1.24959310
57MP0002882_abnormal_neuron_morphology1.22974445
58MP0002876_abnormal_thyroid_physiology1.19783677
59MP0003121_genomic_imprinting1.19278023
60MP0002751_abnormal_autonomic_nervous1.18853056
61MP0002163_abnormal_gland_morphology1.17391977
62MP0003638_abnormal_response/metabolism_1.16942717
63MP0002066_abnormal_motor_capabilities/c1.15385017
64MP0004885_abnormal_endolymph1.14846196
65MP0008789_abnormal_olfactory_epithelium1.14614265
66MP0003633_abnormal_nervous_system1.13339633
67MP0000751_myopathy1.11599713
68MP0003329_amyloid_beta_deposits1.11208602
69MP0005394_taste/olfaction_phenotype1.07409947
70MP0005499_abnormal_olfactory_system1.07409947
71MP0000343_altered_response_to1.07395166
72MP0004133_heterotaxia1.06323093
73MP0001756_abnormal_urination1.05084503
74MP0008569_lethality_at_weaning1.04698920
75MP0000955_abnormal_spinal_cord1.04685216
76MP0002752_abnormal_somatic_nervous1.03303351
77MP0002229_neurodegeneration1.00882817
78MP0003075_altered_response_to1.00181052
79MP0001485_abnormal_pinna_reflex0.99227225
80MP0006035_abnormal_mitochondrial_morpho0.99176921
81MP0003136_yellow_coat_color0.98011372
82MP0001963_abnormal_hearing_physiology0.96409535
83MP0003634_abnormal_glial_cell0.96374469
84MP0004811_abnormal_neuron_physiology0.95495780
85MP0006072_abnormal_retinal_apoptosis0.95226679
86MP0001502_abnormal_circadian_rhythm0.94741662
87MP0005379_endocrine/exocrine_gland_phen0.94260836
88MP0000013_abnormal_adipose_tissue0.91732387
89MP0000631_abnormal_neuroendocrine_gland0.91566597
90MP0006292_abnormal_olfactory_placode0.90765762
91MP0000538_abnormal_urinary_bladder0.90638249
92MP0000230_abnormal_systemic_arterial0.88421082
93MP0006036_abnormal_mitochondrial_physio0.87291027
94MP0003879_abnormal_hair_cell0.86284013
95MP0000026_abnormal_inner_ear0.84965577
96MP0003806_abnormal_nucleotide_metabolis0.84781885
97MP0005410_abnormal_fertilization0.84466254
98MP0002090_abnormal_vision0.82688051
99MP0005503_abnormal_tendon_morphology0.82515843
100MP0005083_abnormal_biliary_tract0.82430851
101MP0002295_abnormal_pulmonary_circulatio0.82180213
102MP0003787_abnormal_imprinting0.81907432
103MP0008872_abnormal_physiological_respon0.80654214
104MP0003938_abnormal_ear_development0.79182876
105MP0008875_abnormal_xenobiotic_pharmacok0.77501536
106MP0000639_abnormal_adrenal_gland0.75225196
107MP0002938_white_spotting0.75181884
108MP0001727_abnormal_embryo_implantation0.74791103
109MP0001542_abnormal_bone_strength0.74063812
110MP0004019_abnormal_vitamin_homeostasis0.73420528
111MP0004134_abnormal_chest_morphology0.73187479
112MP0005636_abnormal_mineral_homeostasis0.73074997
113MP0002102_abnormal_ear_morphology0.72452535
114MP0008004_abnormal_stomach_pH0.71725138
115MP0004085_abnormal_heartbeat0.68630243
116MP0001664_abnormal_digestion0.68626254
117MP0005535_abnormal_body_temperature0.67897132
118MP0004036_abnormal_muscle_relaxation0.66429167
119MP0002152_abnormal_brain_morphology0.66239804
120MP0004145_abnormal_muscle_electrophysio0.65581743
121MP0009250_abnormal_appendicular_skeleto0.65135845
122MP0004381_abnormal_hair_follicle0.63642951
123MP0005253_abnormal_eye_physiology0.63355702
124MP0005084_abnormal_gallbladder_morpholo0.60747072
125MP0002069_abnormal_eating/drinking_beha0.60041564
126MP0002332_abnormal_exercise_endurance0.57987679
127MP0003631_nervous_system_phenotype0.57825136

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.71752571
2Abnormal mitochondria in muscle tissue (HP:0008316)6.00884819
3Mitochondrial inheritance (HP:0001427)5.78033932
4Progressive macrocephaly (HP:0004481)5.75133307
5Acute encephalopathy (HP:0006846)5.23891570
6Hepatocellular necrosis (HP:0001404)4.79350331
7Increased CSF lactate (HP:0002490)4.77915528
8Increased hepatocellular lipid droplets (HP:0006565)4.32459448
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.14027388
10Renal Fanconi syndrome (HP:0001994)4.13612755
11Myokymia (HP:0002411)4.04597812
12Focal motor seizures (HP:0011153)3.85096152
13Hepatic necrosis (HP:0002605)3.78410963
14Abnormality of glycolysis (HP:0004366)3.74263358
15Increased serum pyruvate (HP:0003542)3.74263358
16Lipid accumulation in hepatocytes (HP:0006561)3.65466168
17Optic disc pallor (HP:0000543)3.59442391
18Leukodystrophy (HP:0002415)3.54350260
19Parakeratosis (HP:0001036)3.53766857
20Neuroendocrine neoplasm (HP:0100634)3.48085662
213-Methylglutaconic aciduria (HP:0003535)3.44571796
22Hypothermia (HP:0002045)3.43611719
23Pheochromocytoma (HP:0002666)3.43481154
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.40182548
25Respiratory failure (HP:0002878)3.29810007
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.26059249
27Increased intramyocellular lipid droplets (HP:0012240)3.18375770
28Atonic seizures (HP:0010819)3.16797223
29Exercise intolerance (HP:0003546)3.16697966
30Cerebral edema (HP:0002181)3.16190034
31Focal dystonia (HP:0004373)3.11399685
32Limb dystonia (HP:0002451)3.09160588
33Abnormal hair whorl (HP:0010721)2.98752374
34Craniofacial dystonia (HP:0012179)2.95672319
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90982251
36Lactic acidosis (HP:0003128)2.88977858
37Purpura (HP:0000979)2.88118935
38Medial flaring of the eyebrow (HP:0010747)2.79130403
39Exertional dyspnea (HP:0002875)2.77694160
40Gait imbalance (HP:0002141)2.70561691
41Abnormality of renal resorption (HP:0011038)2.70460604
42Congenital ichthyosiform erythroderma (HP:0007431)2.70170975
43Retinal dysplasia (HP:0007973)2.68751813
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65934310
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65934310
46Torticollis (HP:0000473)2.65485944
47Generalized aminoaciduria (HP:0002909)2.64459122
48Increased serum lactate (HP:0002151)2.63602604
49Epileptic encephalopathy (HP:0200134)2.61108051
50Absence seizures (HP:0002121)2.58438488
51Sensory axonal neuropathy (HP:0003390)2.57992221
52Congenital primary aphakia (HP:0007707)2.51742314
53X-linked dominant inheritance (HP:0001423)2.51199668
54Increased muscle lipid content (HP:0009058)2.48872366
55Poor suck (HP:0002033)2.44936331
56Hyperthyroidism (HP:0000836)2.41771169
57Petechiae (HP:0000967)2.39006794
58Nephrogenic diabetes insipidus (HP:0009806)2.38091021
59Vaginal atresia (HP:0000148)2.36339198
60Dialeptic seizures (HP:0011146)2.36314130
61Respiratory difficulties (HP:0002880)2.36259247
62Genital tract atresia (HP:0001827)2.34461209
63Agitation (HP:0000713)2.33650224
64Menorrhagia (HP:0000132)2.32760321
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26552012
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.26552012
67Focal seizures (HP:0007359)2.25288208
68Abnormal pupillary function (HP:0007686)2.24262237
69Polyphagia (HP:0002591)2.19924745
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18821275
71Glycosuria (HP:0003076)2.18111922
72Abnormality of urine glucose concentration (HP:0011016)2.18111922
73Abnormal respiratory motile cilium physiology (HP:0012261)2.11999816
74Mutism (HP:0002300)2.10671330
75Progressive cerebellar ataxia (HP:0002073)2.08166549
76Emotional lability (HP:0000712)2.06410600
77Abnormality of cells of the erythroid lineage (HP:0012130)2.05971487
78Febrile seizures (HP:0002373)2.05433274
79Visual hallucinations (HP:0002367)2.04772891
80Hyperventilation (HP:0002883)2.03691481
81Anxiety (HP:0000739)2.03089862
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98100147
83Action tremor (HP:0002345)1.96694897
84Abnormal number of erythroid precursors (HP:0012131)1.93376324
85Cerebral hemorrhage (HP:0001342)1.90717206
86Epileptiform EEG discharges (HP:0011182)1.89842511
87Abnormal respiratory motile cilium morphology (HP:0005938)1.89771015
88Abnormal respiratory epithelium morphology (HP:0012253)1.89771015
89Abnormality of magnesium homeostasis (HP:0004921)1.89591695
90Esotropia (HP:0000565)1.89179422
91Neurofibrillary tangles (HP:0002185)1.87969440
92Cerebral hypomyelination (HP:0006808)1.87199977
93Delusions (HP:0000746)1.86662725
94Upper limb muscle weakness (HP:0003484)1.86317526
95Prolonged neonatal jaundice (HP:0006579)1.85281745
96Amblyopia (HP:0000646)1.82840615
97EEG with generalized epileptiform discharges (HP:0011198)1.80256015
98Lethargy (HP:0001254)1.79727537
99CNS demyelination (HP:0007305)1.79370122
100Macrocytic anemia (HP:0001972)1.78592463
101Amniotic constriction ring (HP:0009775)1.78174034
102Abnormality of placental membranes (HP:0011409)1.78174034
103Generalized tonic-clonic seizures (HP:0002069)1.77909984
104Abnormal gallbladder physiology (HP:0012438)1.76018923
105Cholecystitis (HP:0001082)1.76018923
106Abnormality of binocular vision (HP:0011514)1.74230818
107Diplopia (HP:0000651)1.74230818
108Hyperphosphaturia (HP:0003109)1.73299813
109Aplasia/Hypoplasia of the lens (HP:0008063)1.72961012
110Hypsarrhythmia (HP:0002521)1.72438968
111Cerebral inclusion bodies (HP:0100314)1.69914166
112Growth hormone excess (HP:0000845)1.67945641
113Methylmalonic acidemia (HP:0002912)1.66892376
114Abnormal urine phosphate concentration (HP:0012599)1.66608195
115Autoamputation (HP:0001218)1.66268587
116Broad-based gait (HP:0002136)1.65679249
117Failure to thrive in infancy (HP:0001531)1.65648012
118Akinesia (HP:0002304)1.65207187
119Progressive inability to walk (HP:0002505)1.64973045
120Axonal loss (HP:0003447)1.64527115
121Spastic tetraplegia (HP:0002510)1.64313976
122Rhinitis (HP:0012384)1.63943640
123Specific learning disability (HP:0001328)1.59490558
124Abnormality of the corticospinal tract (HP:0002492)1.58531823
125Abnormal autonomic nervous system physiology (HP:0012332)1.58356150
126Supranuclear gaze palsy (HP:0000605)1.58191808
127Diminished movement (HP:0002374)1.57124009
128Septate vagina (HP:0001153)1.56883373
129Poor coordination (HP:0002370)1.55378178
130Respiratory insufficiency due to muscle weakness (HP:0002747)1.52671577
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.52605511
132Abnormal ciliary motility (HP:0012262)1.52413283
133Renal tubular dysfunction (HP:0000124)1.50322576
134Abnormal eating behavior (HP:0100738)1.48501294
135Psychosis (HP:0000709)1.47822008
136Delayed gross motor development (HP:0002194)1.47746657
137Short tibia (HP:0005736)1.47020985
138Myotonia (HP:0002486)1.46293327
139Blindness (HP:0000618)1.46151124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.91159879
2CASK3.56192220
3NME12.96139225
4ARAF2.90860155
5VRK22.82248636
6STK162.53419332
7STK392.42941615
8LIMK12.36794208
9MAP2K72.30928995
10CDK192.25470635
11OXSR12.17688504
12MST42.11313719
13MARK12.05690967
14TNIK2.00330324
15GRK71.90917824
16BCR1.89575814
17MYLK1.86784805
18GRK51.81502998
19MAP3K111.79075101
20BMPR1B1.68329981
21NTRK31.68220368
22MAP3K41.63338868
23PLK21.62916861
24PBK1.59092048
25MINK11.55913641
26MAPKAPK51.54411333
27BCKDK1.54082345
28PIM21.49881098
29MAPK131.47737583
30BMPR21.42934700
31ADRBK21.39957664
32UHMK11.35697672
33PNCK1.34417915
34PINK11.34304923
35BRAF1.32779554
36WNK41.30334577
37DYRK21.24890431
38EPHA41.24177960
39MUSK1.22180017
40LMTK21.21798174
41CAMK2B1.21397435
42RIPK41.19980875
43TRIM281.17740592
44BRSK11.17261128
45PRKD31.16503688
46MAPK151.15257336
47CSNK1G31.08804506
48PRPF4B1.06947173
49CAMK2A1.06715372
50NME21.05851511
51DMPK1.02834773
52EPHA20.99683129
53NTRK10.98931905
54SIK30.98586647
55ADRBK10.95535324
56PRKCE0.94689847
57CAMK2D0.94360509
58CDK140.91140975
59VRK10.90540549
60MAP2K40.87173204
61ROCK20.86889083
62PAK10.86723016
63EIF2AK10.86417655
64NTRK20.85485172
65TAOK20.84439472
66CAMKK20.84395842
67IRAK20.83958370
68PRKCG0.82581777
69CSNK1G20.81650218
70TESK10.81398326
71PKN10.81058762
72CDK180.80879525
73BUB10.80704987
74CAMK2G0.79638731
75CDK50.78206632
76BMX0.77277274
77AURKA0.76094697
78SIK20.75102300
79CDK150.74051014
80PAK60.72379350
81PAK30.71662750
82PRKCI0.71212500
83PDK20.69990929
84MAPKAPK30.69677970
85DAPK10.68215417
86CDK11A0.65977402
87DAPK30.65971131
88MAP4K20.65160363
89AKT30.63175410
90IRAK10.61717259
91PTK20.60753585
92TNK20.57727864
93MAP3K90.57388441
94PHKG20.56955755
95PHKG10.56955755
96WNK30.56710105
97ILK0.56570770
98TSSK60.55963367
99DYRK30.55941307
100LRRK20.55683396
101FGR0.54551371
102SGK2230.54463889
103SGK4940.54463889
104CSNK1G10.54162297
105IRAK30.53740293
106TAOK10.52666488
107ERBB30.51597550
108PTK2B0.51424619
109ABL20.49787329
110CSNK1A1L0.49701971
111DAPK20.49390953
112NEK60.49316678
113CDK80.47282709
114DYRK1A0.47036708
115CDK30.46117046
116TLK10.46080041
117GRK10.45502689
118* PRKACA0.45065229
119CAMK10.42553208
120PRKG10.41623398
121TESK20.40846278
122EPHB20.40486892
123CAMKK10.39941049
124YES10.38714942
125PRKCA0.38040159
126PRKD10.37917478
127OBSCN0.36531219
128WNK10.36309578
129RAF10.34779563
130ROCK10.34535253
131FES0.34002861
132EIF2AK30.32704374

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.02609279
2Parkinsons disease_Homo sapiens_hsa050124.97748763
3Alzheimers disease_Homo sapiens_hsa050103.87915941
4Huntingtons disease_Homo sapiens_hsa050163.42884259
5Proteasome_Homo sapiens_hsa030503.10280697
6Collecting duct acid secretion_Homo sapiens_hsa049663.08757430
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.96640126
8Synaptic vesicle cycle_Homo sapiens_hsa047212.51483557
9Cardiac muscle contraction_Homo sapiens_hsa042602.43430323
10Protein export_Homo sapiens_hsa030602.43012965
11Nicotine addiction_Homo sapiens_hsa050332.27073140
12Ribosome_Homo sapiens_hsa030102.24076248
13Vibrio cholerae infection_Homo sapiens_hsa051102.21786976
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93125209
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68296578
16Serotonergic synapse_Homo sapiens_hsa047261.67786733
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66542757
18RNA polymerase_Homo sapiens_hsa030201.63719820
19Fatty acid elongation_Homo sapiens_hsa000621.63487285
20GABAergic synapse_Homo sapiens_hsa047271.56725235
21Rheumatoid arthritis_Homo sapiens_hsa053231.52081063
22Folate biosynthesis_Homo sapiens_hsa007901.43509840
23Morphine addiction_Homo sapiens_hsa050321.38039871
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29672868
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29513348
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28874398
27Olfactory transduction_Homo sapiens_hsa047401.28111417
28Steroid biosynthesis_Homo sapiens_hsa001001.24354300
29Taste transduction_Homo sapiens_hsa047421.23076388
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16811821
31Dopaminergic synapse_Homo sapiens_hsa047281.16021265
32Circadian entrainment_Homo sapiens_hsa047131.15543975
33Sulfur relay system_Homo sapiens_hsa041221.12991798
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09945891
35Phagosome_Homo sapiens_hsa041451.09789644
36Glutamatergic synapse_Homo sapiens_hsa047241.09744108
37Phototransduction_Homo sapiens_hsa047441.09045533
38Amphetamine addiction_Homo sapiens_hsa050311.00869465
39Sulfur metabolism_Homo sapiens_hsa009200.98480823
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97862095
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96042287
42Long-term depression_Homo sapiens_hsa047300.89935336
43Cocaine addiction_Homo sapiens_hsa050300.88925798
44Arginine and proline metabolism_Homo sapiens_hsa003300.88862598
45Cholinergic synapse_Homo sapiens_hsa047250.87866722
46Ether lipid metabolism_Homo sapiens_hsa005650.87048980
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74532612
48Long-term potentiation_Homo sapiens_hsa047200.74228596
49beta-Alanine metabolism_Homo sapiens_hsa004100.73278537
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71795778
51Axon guidance_Homo sapiens_hsa043600.71569990
52Sphingolipid metabolism_Homo sapiens_hsa006000.71501721
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71100096
54Mineral absorption_Homo sapiens_hsa049780.70838353
55Peroxisome_Homo sapiens_hsa041460.70467175
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.65606043
57Renin secretion_Homo sapiens_hsa049240.64053654
58Salivary secretion_Homo sapiens_hsa049700.63409382
59Calcium signaling pathway_Homo sapiens_hsa040200.57663011
60Insulin secretion_Homo sapiens_hsa049110.57414745
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.56732508
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55344832
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55221688
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54963089
65Chemical carcinogenesis_Homo sapiens_hsa052040.54911511
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54514741
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52720589
68Metabolic pathways_Homo sapiens_hsa011000.52708210
69Tyrosine metabolism_Homo sapiens_hsa003500.51866075
70Vitamin B6 metabolism_Homo sapiens_hsa007500.51726888
71Endocytosis_Homo sapiens_hsa041440.50529835
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50274916
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49201606
74Lysosome_Homo sapiens_hsa041420.49169764
75Asthma_Homo sapiens_hsa053100.48877043
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48662091
77Gap junction_Homo sapiens_hsa045400.48006712
78Gastric acid secretion_Homo sapiens_hsa049710.47109863
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46346880
80Autoimmune thyroid disease_Homo sapiens_hsa053200.45775599
81Oxytocin signaling pathway_Homo sapiens_hsa049210.45687930
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45427735
83Galactose metabolism_Homo sapiens_hsa000520.45191350
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44862031
85Graft-versus-host disease_Homo sapiens_hsa053320.44663198
86Regulation of autophagy_Homo sapiens_hsa041400.44534259
87Pyruvate metabolism_Homo sapiens_hsa006200.44222350
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44208794
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.44054226
90Type I diabetes mellitus_Homo sapiens_hsa049400.43477142
91Alcoholism_Homo sapiens_hsa050340.43195568
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43029303
93Arachidonic acid metabolism_Homo sapiens_hsa005900.42800904
94Phenylalanine metabolism_Homo sapiens_hsa003600.42121390
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40773181
96Nitrogen metabolism_Homo sapiens_hsa009100.39792345
97Purine metabolism_Homo sapiens_hsa002300.38635328
98Allograft rejection_Homo sapiens_hsa053300.36175171
99Pyrimidine metabolism_Homo sapiens_hsa002400.33903234
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33353815
101Fat digestion and absorption_Homo sapiens_hsa049750.32538632
102Prion diseases_Homo sapiens_hsa050200.31898237
103Carbon metabolism_Homo sapiens_hsa012000.31819756
104GnRH signaling pathway_Homo sapiens_hsa049120.31200849
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30844477
106Fatty acid metabolism_Homo sapiens_hsa012120.30810127
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29529801
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29392826
109Butanoate metabolism_Homo sapiens_hsa006500.29105352
110African trypanosomiasis_Homo sapiens_hsa051430.28952018
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28670956
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28133618
113Melanogenesis_Homo sapiens_hsa049160.27936625
114Linoleic acid metabolism_Homo sapiens_hsa005910.27790357
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27597232
116Pentose phosphate pathway_Homo sapiens_hsa000300.27551805
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.26973929
118Ras signaling pathway_Homo sapiens_hsa040140.26319437
119Glutathione metabolism_Homo sapiens_hsa004800.22525511
120Basal transcription factors_Homo sapiens_hsa030220.20347691
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20208363
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.18877540
123cAMP signaling pathway_Homo sapiens_hsa040240.18832000
124Salmonella infection_Homo sapiens_hsa051320.18252415
125Dilated cardiomyopathy_Homo sapiens_hsa054140.16826921
126ErbB signaling pathway_Homo sapiens_hsa040120.14208321
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12395216
128Pancreatic secretion_Homo sapiens_hsa049720.12199310
129Ovarian steroidogenesis_Homo sapiens_hsa049130.12138584
130Renal cell carcinoma_Homo sapiens_hsa052110.11797697
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10626945
132Malaria_Homo sapiens_hsa051440.08746134
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07703845

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