DYNLT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.89338297
2ATP synthesis coupled proton transport (GO:0015986)6.06370214
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.06370214
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.89519290
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.24495411
6respiratory electron transport chain (GO:0022904)5.24105602
7electron transport chain (GO:0022900)5.18631599
8epithelial cilium movement (GO:0003351)5.11051329
9protein complex biogenesis (GO:0070271)4.97433069
10protein neddylation (GO:0045116)4.93940954
11axonemal dynein complex assembly (GO:0070286)4.87016672
12chaperone-mediated protein transport (GO:0072321)4.74601340
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.57466806
14mitochondrial respiratory chain complex assembly (GO:0033108)4.56096230
15cilium movement (GO:0003341)4.55258485
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.50670114
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.50670114
18NADH dehydrogenase complex assembly (GO:0010257)4.50670114
19sequestering of actin monomers (GO:0042989)4.48589202
20regulation of cilium movement (GO:0003352)4.16996481
21proteasome assembly (GO:0043248)4.16896921
22platelet dense granule organization (GO:0060155)4.16570733
23intraciliary transport (GO:0042073)4.07409401
24respiratory chain complex IV assembly (GO:0008535)3.97288336
25pyrimidine nucleobase catabolic process (GO:0006208)3.90217561
26behavioral response to nicotine (GO:0035095)3.74309858
27cullin deneddylation (GO:0010388)3.72969330
28hydrogen ion transmembrane transport (GO:1902600)3.68005930
29cytochrome complex assembly (GO:0017004)3.66935733
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62823069
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62823069
32protein localization to cilium (GO:0061512)3.58250909
33protein deneddylation (GO:0000338)3.55224155
34proton transport (GO:0015992)3.44471758
35axoneme assembly (GO:0035082)3.44199321
36ATP biosynthetic process (GO:0006754)3.41498030
37nonmotile primary cilium assembly (GO:0035058)3.40807436
38purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38485234
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38203246
40hydrogen transport (GO:0006818)3.36336037
41termination of RNA polymerase III transcription (GO:0006386)3.34977335
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.34977335
43GTP biosynthetic process (GO:0006183)3.27769761
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25548740
45protein-cofactor linkage (GO:0018065)3.25496387
46organelle disassembly (GO:1903008)3.22284534
47nucleobase catabolic process (GO:0046113)3.21245711
48cilium or flagellum-dependent cell motility (GO:0001539)3.19949627
49water-soluble vitamin biosynthetic process (GO:0042364)3.16568880
50cilium morphogenesis (GO:0060271)3.15662897
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10838999
52regulation of mitochondrial translation (GO:0070129)3.09338213
53cilium organization (GO:0044782)3.08572990
54regulation of cellular amino acid metabolic process (GO:0006521)3.07982255
55anterograde synaptic vesicle transport (GO:0048490)3.06377240
56cilium assembly (GO:0042384)3.03845985
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99283854
58nucleoside diphosphate phosphorylation (GO:0006165)2.90683178
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90650210
60ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87706788
61protein localization to mitochondrion (GO:0070585)2.87338530
62cotranslational protein targeting to membrane (GO:0006613)2.83563285
63intracellular protein transmembrane import (GO:0044743)2.83405489
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83285854
65protein targeting to mitochondrion (GO:0006626)2.82079228
66establishment of protein localization to mitochondrion (GO:0072655)2.81631775
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81183226
68nucleoside triphosphate biosynthetic process (GO:0009142)2.79188711
69DNA damage response, detection of DNA damage (GO:0042769)2.78014721
70positive regulation of mitochondrial fission (GO:0090141)2.77654113
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77526565
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77526565
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77526565
74protein targeting to ER (GO:0045047)2.77345373
75neuron fate determination (GO:0048664)2.76438195
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76067378
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76067378
78negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72302155
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67419524
80protein polyglutamylation (GO:0018095)2.67269892
81negative regulation of ligase activity (GO:0051352)2.67190367
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67190367
83establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66621012
84ubiquinone metabolic process (GO:0006743)2.64742898
85retinal ganglion cell axon guidance (GO:0031290)2.64403632
86inner mitochondrial membrane organization (GO:0007007)2.64358659
87protein localization to endoplasmic reticulum (GO:0070972)2.63368999
88base-excision repair, AP site formation (GO:0006285)2.63138759
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.62361676
90regulation of microtubule-based movement (GO:0060632)2.61432385
91left/right pattern formation (GO:0060972)2.58869824
92aldehyde catabolic process (GO:0046185)2.58251249
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.57290608
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57290608
95ubiquinone biosynthetic process (GO:0006744)2.57068292
96DNA deamination (GO:0045006)2.56741007
97mannosylation (GO:0097502)2.53747968
98negative regulation of telomere maintenance (GO:0032205)2.52431174
99viral transcription (GO:0019083)2.49880360
100peptidyl-histidine modification (GO:0018202)2.48267643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03536168
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.96981337
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38864149
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.30696757
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17185458
6ZNF274_21170338_ChIP-Seq_K562_Hela2.95587595
7ELK1_19687146_ChIP-ChIP_HELA_Human2.39979072
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35607492
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31293451
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26947456
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26290701
12VDR_22108803_ChIP-Seq_LS180_Human2.22797685
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21685126
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13519744
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.11981415
16* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07634029
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07549607
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99314778
19IGF1R_20145208_ChIP-Seq_DFB_Human1.95492754
20FUS_26573619_Chip-Seq_HEK293_Human1.95370047
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91025379
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90800133
23EWS_26573619_Chip-Seq_HEK293_Human1.89080295
24* VDR_23849224_ChIP-Seq_CD4+_Human1.86817319
25GBX2_23144817_ChIP-Seq_PC3_Human1.82171190
26P300_19829295_ChIP-Seq_ESCs_Human1.79933918
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76127134
28EZH2_22144423_ChIP-Seq_EOC_Human1.74320757
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73608333
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.66630610
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65357041
32MYC_18940864_ChIP-ChIP_HL60_Human1.63316614
33TAF15_26573619_Chip-Seq_HEK293_Human1.62480555
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.62341812
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47368940
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47358752
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46950552
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46676018
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39172167
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.38952033
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33347155
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31950445
43* TP53_22573176_ChIP-Seq_HFKS_Human1.29001668
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.28529096
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26479150
46CBP_20019798_ChIP-Seq_JUKART_Human1.23394284
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23394284
48FOXP3_21729870_ChIP-Seq_TREG_Human1.23009413
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22192066
50NANOG_19829295_ChIP-Seq_ESCs_Human1.21907649
51SOX2_19829295_ChIP-Seq_ESCs_Human1.21907649
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.20968799
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20833081
54ER_23166858_ChIP-Seq_MCF-7_Human1.17802342
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.17531053
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17531053
57IRF1_19129219_ChIP-ChIP_H3396_Human1.17438089
58RNF2_27304074_Chip-Seq_NSC_Mouse1.17404581
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17367825
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16885955
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.15842582
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15007982
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13833092
64BCAT_22108803_ChIP-Seq_LS180_Human1.13607107
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.13195328
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.11265163
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10810191
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10599988
69GABP_19822575_ChIP-Seq_HepG2_Human1.09385037
70AR_20517297_ChIP-Seq_VCAP_Human1.08661322
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08557278
72AR_25329375_ChIP-Seq_VCAP_Human1.07544421
73DCP1A_22483619_ChIP-Seq_HELA_Human1.05353624
74SMAD4_21799915_ChIP-Seq_A2780_Human1.05058105
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.03014546
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03010633
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03009061
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02445878
79NCOR_22424771_ChIP-Seq_293T_Human1.01775139
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00281783
81TCF4_22108803_ChIP-Seq_LS180_Human0.99911770
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99640120
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99527513
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99135744
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.98586980
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97755678
87SMAD3_21741376_ChIP-Seq_EPCs_Human0.97161200
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96819276
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95245063
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94794603
91P53_22387025_ChIP-Seq_ESCs_Mouse0.94115570
92HTT_18923047_ChIP-ChIP_STHdh_Human0.93814737
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.92930084
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92929808
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92900304
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92900304
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92886219
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92749453
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.92224687
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91472406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.04149299
2MP0001529_abnormal_vocalization2.91789465
3MP0008789_abnormal_olfactory_epithelium2.69269824
4MP0002653_abnormal_ependyma_morphology2.45741865
5MP0003011_delayed_dark_adaptation2.43881566
6MP0006292_abnormal_olfactory_placode2.38626050
7MP0001984_abnormal_olfaction2.35218881
8MP0005084_abnormal_gallbladder_morpholo2.29006380
9MP0005499_abnormal_olfactory_system2.21959276
10MP0005394_taste/olfaction_phenotype2.21959276
11MP0002638_abnormal_pupillary_reflex2.15410495
12MP0002277_abnormal_respiratory_mucosa2.10694206
13MP0003195_calcinosis2.04638338
14MP0004142_abnormal_muscle_tone2.00675171
15MP0003136_yellow_coat_color1.99069020
16MP0004133_heterotaxia1.97923343
17MP0006072_abnormal_retinal_apoptosis1.95825584
18MP0006276_abnormal_autonomic_nervous1.94664429
19MP0003122_maternal_imprinting1.93889595
20MP0003806_abnormal_nucleotide_metabolis1.93681960
21MP0003880_abnormal_central_pattern1.87056200
22MP0002837_dystrophic_cardiac_calcinosis1.86921036
23MP0002938_white_spotting1.84745711
24MP0000372_irregular_coat_pigmentation1.82452060
25MP0003121_genomic_imprinting1.77523949
26MP0002163_abnormal_gland_morphology1.76206550
27MP0003787_abnormal_imprinting1.73879563
28MP0010386_abnormal_urinary_bladder1.72296566
29MP0008877_abnormal_DNA_methylation1.71155836
30MP0003186_abnormal_redox_activity1.70151099
31MP0008995_early_reproductive_senescence1.63373145
32MP0008875_abnormal_xenobiotic_pharmacok1.62703693
33MP0009379_abnormal_foot_pigmentation1.61162751
34MP0005551_abnormal_eye_electrophysiolog1.60610184
35MP0005253_abnormal_eye_physiology1.60384371
36MP0002736_abnormal_nociception_after1.60326570
37MP0008058_abnormal_DNA_repair1.54235899
38MP0000049_abnormal_middle_ear1.43852215
39MP0000631_abnormal_neuroendocrine_gland1.43379591
40MP0001905_abnormal_dopamine_level1.43072969
41MP0000778_abnormal_nervous_system1.39790691
42MP0001485_abnormal_pinna_reflex1.39538035
43MP0009046_muscle_twitch1.38919974
44MP0002751_abnormal_autonomic_nervous1.36038803
45MP0002282_abnormal_trachea_morphology1.31018599
46MP0009745_abnormal_behavioral_response1.29041935
47MP0001968_abnormal_touch/_nociception1.27059641
48MP0001293_anophthalmia1.20580085
49MP0002822_catalepsy1.20578741
50MP0002234_abnormal_pharynx_morphology1.20208720
51MP0002734_abnormal_mechanical_nocicepti1.20123664
52MP0001970_abnormal_pain_threshold1.19693354
53MP0002272_abnormal_nervous_system1.17573177
54MP0003938_abnormal_ear_development1.17229688
55MP0005379_endocrine/exocrine_gland_phen1.16336494
56MP0002233_abnormal_nose_morphology1.16318589
57MP0002876_abnormal_thyroid_physiology1.14762147
58MP0003283_abnormal_digestive_organ1.12182289
59MP0003718_maternal_effect1.10860576
60MP0002928_abnormal_bile_duct1.10535800
61MP0002909_abnormal_adrenal_gland1.09103229
62MP0002735_abnormal_chemical_nociception1.08322019
63MP0000026_abnormal_inner_ear1.08055969
64MP0005195_abnormal_posterior_eye1.06530928
65MP0001188_hyperpigmentation1.06213208
66MP0010030_abnormal_orbit_morphology1.05667543
67MP0000566_synostosis1.05646892
68MP0002557_abnormal_social/conspecific_i1.05058006
69MP0002752_abnormal_somatic_nervous1.02536797
70MP0006036_abnormal_mitochondrial_physio1.01731069
71MP0001486_abnormal_startle_reflex1.01162007
72MP0005187_abnormal_penis_morphology0.97272658
73MP0000647_abnormal_sebaceous_gland0.96934678
74MP0000516_abnormal_urinary_system0.95599521
75MP0005367_renal/urinary_system_phenotyp0.95599521
76MP0003786_premature_aging0.95337425
77MP0002733_abnormal_thermal_nociception0.94219447
78MP0001324_abnormal_eye_pigmentation0.92038687
79MP0006035_abnormal_mitochondrial_morpho0.91320868
80MP0002572_abnormal_emotion/affect_behav0.91075209
81MP0002160_abnormal_reproductive_system0.91032612
82MP0003890_abnormal_embryonic-extraembry0.90244070
83MP0004019_abnormal_vitamin_homeostasis0.89370893
84MP0001764_abnormal_homeostasis0.89102991
85MP0008872_abnormal_physiological_respon0.87854674
86MP0003937_abnormal_limbs/digits/tail_de0.87279679
87MP0005389_reproductive_system_phenotype0.85234643
88MP0002184_abnormal_innervation0.83614672
89MP0002067_abnormal_sensory_capabilities0.82950022
90MP0005391_vision/eye_phenotype0.82855381
91MP0000955_abnormal_spinal_cord0.78843236
92MP0003755_abnormal_palate_morphology0.77827862
93MP0002132_abnormal_respiratory_system0.75339387
94MP0001286_abnormal_eye_development0.74922497
95MP0005645_abnormal_hypothalamus_physiol0.73613344
96MP0004885_abnormal_endolymph0.72412919
97MP0001919_abnormal_reproductive_system0.72376177
98MP0000538_abnormal_urinary_bladder0.72105068
99MP0001963_abnormal_hearing_physiology0.69495437
100MP0005248_abnormal_Harderian_gland0.69479044

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.96067639
2Abnormal mitochondria in muscle tissue (HP:0008316)4.38916731
3Mitochondrial inheritance (HP:0001427)4.34183915
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.30628166
5Acute encephalopathy (HP:0006846)4.20970231
6Progressive macrocephaly (HP:0004481)4.18731909
7Abnormal respiratory motile cilium physiology (HP:0012261)4.12493684
8Abnormal respiratory motile cilium morphology (HP:0005938)4.12286465
9Abnormal respiratory epithelium morphology (HP:0012253)4.12286465
10Abnormal ciliary motility (HP:0012262)4.04416602
11Abnormality of midbrain morphology (HP:0002418)3.76205051
12Molar tooth sign on MRI (HP:0002419)3.76205051
13True hermaphroditism (HP:0010459)3.75171909
14Increased CSF lactate (HP:0002490)3.74630962
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.72486655
16Absent/shortened dynein arms (HP:0200106)3.72486655
17Pancreatic fibrosis (HP:0100732)3.71951531
18Pancreatic cysts (HP:0001737)3.67795230
19Medial flaring of the eyebrow (HP:0010747)3.59955124
203-Methylglutaconic aciduria (HP:0003535)3.59222360
21Increased hepatocellular lipid droplets (HP:0006565)3.57902628
22Rhinitis (HP:0012384)3.47304299
23Hepatocellular necrosis (HP:0001404)3.45981021
24Lipid accumulation in hepatocytes (HP:0006561)3.35156926
25Nephronophthisis (HP:0000090)3.34415777
26Hepatic necrosis (HP:0002605)3.23938577
27Gait imbalance (HP:0002141)3.16534831
28Renal Fanconi syndrome (HP:0001994)3.13314952
29Congenital primary aphakia (HP:0007707)3.06365161
30Cerebral edema (HP:0002181)2.97765342
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90252162
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90252162
33Nephrogenic diabetes insipidus (HP:0009806)2.88972394
34Abnormality of the renal medulla (HP:0100957)2.62213843
35Abnormality of the labia minora (HP:0012880)2.61577573
36Optic disc pallor (HP:0000543)2.60125464
37Exertional dyspnea (HP:0002875)2.51978730
38Polyphagia (HP:0002591)2.51920032
39Chronic bronchitis (HP:0004469)2.51480443
40Genital tract atresia (HP:0001827)2.49900901
41Occipital encephalocele (HP:0002085)2.46967342
42Respiratory failure (HP:0002878)2.46819687
43Vaginal atresia (HP:0000148)2.45799700
44Methylmalonic acidemia (HP:0002912)2.43724268
45Sclerocornea (HP:0000647)2.39164420
46Lactic acidosis (HP:0003128)2.37940132
47Anencephaly (HP:0002323)2.35112821
48Methylmalonic aciduria (HP:0012120)2.34300546
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30972617
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.28365699
51Increased intramyocellular lipid droplets (HP:0012240)2.24851782
52Bronchiectasis (HP:0002110)2.24268747
53Abnormality of urine glucose concentration (HP:0011016)2.23825160
54Glycosuria (HP:0003076)2.23825160
55Abnormality of renal resorption (HP:0011038)2.22059021
56Male pseudohermaphroditism (HP:0000037)2.19986550
57Exercise intolerance (HP:0003546)2.15592453
58Postaxial foot polydactyly (HP:0001830)2.15028974
59Cystic liver disease (HP:0006706)2.13930252
60Increased serum lactate (HP:0002151)2.13570442
61Postaxial hand polydactyly (HP:0001162)2.08075104
62Congenital, generalized hypertrichosis (HP:0004540)2.05066301
63Abnormal number of erythroid precursors (HP:0012131)2.02990350
64Limb dystonia (HP:0002451)2.02950211
65Leukodystrophy (HP:0002415)2.01059483
66Lethargy (HP:0001254)1.99493407
67Hypothermia (HP:0002045)1.97070014
68X-linked dominant inheritance (HP:0001423)1.96405870
69Hyperglycinemia (HP:0002154)1.96361916
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94433081
71Poor suck (HP:0002033)1.93114994
72Type II lissencephaly (HP:0007260)1.93082513
73Retinal dysplasia (HP:0007973)1.91915730
74Septo-optic dysplasia (HP:0100842)1.91275049
75Abnormality of the renal cortex (HP:0011035)1.89558966
76Aplasia/hypoplasia of the uterus (HP:0008684)1.86087038
77Concave nail (HP:0001598)1.85993792
78Congenital hepatic fibrosis (HP:0002612)1.85456204
79Hyperphosphaturia (HP:0003109)1.81846442
80Respiratory difficulties (HP:0002880)1.81644524
81Abnormality of cells of the erythroid lineage (HP:0012130)1.79881353
82Type 2 muscle fiber atrophy (HP:0003554)1.79664093
83Oculomotor apraxia (HP:0000657)1.77600051
84Generalized aminoaciduria (HP:0002909)1.77375889
85Congenital stationary night blindness (HP:0007642)1.77221735
86Increased muscle lipid content (HP:0009058)1.77103354
87Tubular atrophy (HP:0000092)1.77100785
88Poor coordination (HP:0002370)1.76333542
89Chronic sinusitis (HP:0011109)1.76122010
90Narrow forehead (HP:0000341)1.76018069
91Myokymia (HP:0002411)1.74867846
92Intestinal atresia (HP:0011100)1.71691385
93Preaxial hand polydactyly (HP:0001177)1.69676349
94Lissencephaly (HP:0001339)1.69431061
95Colon cancer (HP:0003003)1.68968783
96Optic nerve hypoplasia (HP:0000609)1.68487926
97Chronic hepatic failure (HP:0100626)1.67940004
98Supernumerary spleens (HP:0009799)1.67305842
99Degeneration of anterior horn cells (HP:0002398)1.66194244
100Abnormality of the anterior horn cell (HP:0006802)1.66194244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.05831574
2MAP4K22.77298093
3WNK32.72434900
4MST42.55009082
5MAP3K42.36214532
6TRIM282.33334536
7DYRK22.26189235
8MAP2K72.21779341
9ADRBK22.19143608
10CASK2.18880678
11BCR2.13764460
12MAP3K122.11581030
13VRK22.03876037
14MARK11.98504218
15BMPR1B1.94405492
16TNIK1.93001953
17BCKDK1.87620804
18MAPK151.80218254
19NME11.66063892
20FRK1.62439074
21GRK11.62391642
22MAPK131.56217895
23ZAK1.52924378
24NUAK11.52177875
25VRK11.49872467
26ERBB31.48808004
27INSRR1.48661334
28PINK11.44800156
29CSNK1G21.42815112
30CDK191.42798249
31CSNK1G31.41679252
32SRPK11.34774473
33DYRK31.32055675
34GRK71.31749998
35CSNK1G11.27339112
36TLK11.27065907
37EPHB21.22817007
38PAK31.21345261
39PBK1.20607980
40PLK21.18647331
41CSNK1A1L1.13212489
42LIMK11.10852073
43PNCK1.08977407
44NEK11.03728382
45EPHA31.01185911
46PLK30.99125109
47OXSR10.98804041
48PRKCG0.95376076
49BUB10.94522469
50WEE10.90809127
51PRKCE0.84106934
52STK38L0.81544570
53MINK10.76604802
54ADRBK10.68839851
55BRSK20.67806299
56STK390.67595658
57WNK40.63461395
58PLK40.61171834
59TAOK30.60421740
60PLK10.59350718
61MYLK0.58328761
62MUSK0.55851030
63CCNB10.54216401
64PIM20.53822152
65MKNK20.52600026
66DYRK1B0.52014816
67PHKG20.50368634
68PHKG10.50368634
69ABL20.50147854
70MAP2K40.49652275
71CSNK1A10.48542427
72CAMK2A0.48454288
73PRKACA0.47794781
74EIF2AK30.47289883
75CSNK2A10.47072026
76PKN10.46419981
77CDK80.44276393
78PDK20.44275630
79ACVR1B0.43741475
80PIK3CA0.43719813
81PRKCI0.42006540
82TESK10.40519720
83RPS6KA40.40308679
84STK240.39674877
85MKNK10.39000532
86RPS6KA50.38762438
87EIF2AK10.38544036
88CSNK2A20.38543795
89NTRK20.37041502
90PRKG10.36115471
91DYRK1A0.36078004
92CDC70.35621429
93AURKA0.32362250
94PASK0.31501152
95TXK0.28793608
96TSSK60.27909528
97MAP3K50.26999610
98PRKACB0.26365909
99PRKCA0.26316113
100PTK2B0.25562456

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.08497704
2Parkinsons disease_Homo sapiens_hsa050124.25773872
3Protein export_Homo sapiens_hsa030603.91470196
4Proteasome_Homo sapiens_hsa030503.68232064
5Huntingtons disease_Homo sapiens_hsa050163.15760409
6Ribosome_Homo sapiens_hsa030103.09170642
7Alzheimers disease_Homo sapiens_hsa050102.85456405
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.56730827
9RNA polymerase_Homo sapiens_hsa030202.33372874
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25748917
11Cardiac muscle contraction_Homo sapiens_hsa042602.15062692
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96087872
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87102737
14Collecting duct acid secretion_Homo sapiens_hsa049661.57719500
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55528666
16Homologous recombination_Homo sapiens_hsa034401.50295900
17Sulfur metabolism_Homo sapiens_hsa009201.49298314
18Steroid biosynthesis_Homo sapiens_hsa001001.46352620
19Butanoate metabolism_Homo sapiens_hsa006501.43666396
20Propanoate metabolism_Homo sapiens_hsa006401.40476207
21Basal transcription factors_Homo sapiens_hsa030221.35077659
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26188380
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25692346
24Phototransduction_Homo sapiens_hsa047441.25280092
25Caffeine metabolism_Homo sapiens_hsa002321.25103275
26Chemical carcinogenesis_Homo sapiens_hsa052041.22837329
27Mismatch repair_Homo sapiens_hsa034301.20930942
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20663617
29Folate biosynthesis_Homo sapiens_hsa007901.20119433
30Fatty acid elongation_Homo sapiens_hsa000621.18446268
31Glutathione metabolism_Homo sapiens_hsa004801.18248535
32Peroxisome_Homo sapiens_hsa041461.18172536
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.16005686
34RNA degradation_Homo sapiens_hsa030181.13447445
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11499642
36Nicotine addiction_Homo sapiens_hsa050331.10608007
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10229597
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09746025
39Regulation of autophagy_Homo sapiens_hsa041401.04413854
40Pyrimidine metabolism_Homo sapiens_hsa002401.03964951
41Fanconi anemia pathway_Homo sapiens_hsa034601.03505626
42Tryptophan metabolism_Homo sapiens_hsa003800.98070352
43Linoleic acid metabolism_Homo sapiens_hsa005910.97207811
44Nucleotide excision repair_Homo sapiens_hsa034200.94154809
45Metabolic pathways_Homo sapiens_hsa011000.85423878
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85038979
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82839827
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81903111
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80462895
50Purine metabolism_Homo sapiens_hsa002300.79662129
51Retinol metabolism_Homo sapiens_hsa008300.79135729
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78398864
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75665348
54Spliceosome_Homo sapiens_hsa030400.75493350
55beta-Alanine metabolism_Homo sapiens_hsa004100.69179927
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66381013
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.64898994
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.64266887
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64106922
60Non-homologous end-joining_Homo sapiens_hsa034500.62325460
61Sulfur relay system_Homo sapiens_hsa041220.61241940
62Pyruvate metabolism_Homo sapiens_hsa006200.60768014
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59170903
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58396733
65Rheumatoid arthritis_Homo sapiens_hsa053230.57365117
66Nitrogen metabolism_Homo sapiens_hsa009100.56070780
67Base excision repair_Homo sapiens_hsa034100.55694254
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55673886
69Selenocompound metabolism_Homo sapiens_hsa004500.55299187
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.54693613
71Vibrio cholerae infection_Homo sapiens_hsa051100.53228745
72Ether lipid metabolism_Homo sapiens_hsa005650.52205437
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49878084
74Hedgehog signaling pathway_Homo sapiens_hsa043400.48262300
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47541818
76RNA transport_Homo sapiens_hsa030130.45968439
77Fat digestion and absorption_Homo sapiens_hsa049750.45682681
78Mineral absorption_Homo sapiens_hsa049780.45067546
79Fatty acid degradation_Homo sapiens_hsa000710.44344211
80Arachidonic acid metabolism_Homo sapiens_hsa005900.44075193
81Olfactory transduction_Homo sapiens_hsa047400.44048634
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42882646
83GABAergic synapse_Homo sapiens_hsa047270.42324222
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.41319302
85Basal cell carcinoma_Homo sapiens_hsa052170.41127744
86Tyrosine metabolism_Homo sapiens_hsa003500.40291807
87Taste transduction_Homo sapiens_hsa047420.39254912
88Synaptic vesicle cycle_Homo sapiens_hsa047210.38176398
89Cocaine addiction_Homo sapiens_hsa050300.31446786
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30012368
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29847867
92Arginine and proline metabolism_Homo sapiens_hsa003300.27405870
93Serotonergic synapse_Homo sapiens_hsa047260.26480591
94DNA replication_Homo sapiens_hsa030300.25837238
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24713164
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22793267
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22342407
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22192124
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22152023
100Vitamin digestion and absorption_Homo sapiens_hsa049770.21117288

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »