DYNLT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of type B pancreatic cell apoptotic process (GO:2000674)4.80019484
2cellular ketone body metabolic process (GO:0046950)4.37361261
3regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.03119035
4phosphorylated carbohydrate dephosphorylation (GO:0046838)4.00605814
5inositol phosphate dephosphorylation (GO:0046855)4.00605814
6ketone body metabolic process (GO:1902224)3.95571578
7inositol phosphate catabolic process (GO:0071545)3.89441226
8platelet dense granule organization (GO:0060155)3.88066633
9response to gravity (GO:0009629)3.85569929
10insulin secretion (GO:0030073)3.83366013
11synaptic vesicle exocytosis (GO:0016079)3.76454527
12positive regulation of glycolytic process (GO:0045821)3.73610101
13positive regulation of actin filament depolymerization (GO:0030836)3.63199116
14negative regulation of dendrite morphogenesis (GO:0050774)3.61857291
15inositol phosphate-mediated signaling (GO:0048016)3.53461345
16glutamate secretion (GO:0014047)3.48332070
17regulation of glucokinase activity (GO:0033131)3.43259284
18regulation of hexokinase activity (GO:1903299)3.43259284
19neuronal action potential propagation (GO:0019227)3.43234694
20energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.37389726
21ATP hydrolysis coupled proton transport (GO:0015991)3.37389726
22endocrine pancreas development (GO:0031018)3.33325714
23regulation of integrin-mediated signaling pathway (GO:2001044)3.32922463
24transferrin transport (GO:0033572)3.31380291
25polyol catabolic process (GO:0046174)3.30930237
26regulation of synaptic vesicle exocytosis (GO:2000300)3.23087421
27trivalent inorganic cation transport (GO:0072512)3.21640079
28ferric iron transport (GO:0015682)3.21640079
29signal peptide processing (GO:0006465)3.18718667
30positive regulation of protein autophosphorylation (GO:0031954)3.17051941
31xenobiotic catabolic process (GO:0042178)3.11638206
32L-phenylalanine metabolic process (GO:0006558)3.08380040
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.08380040
34negative regulation of complement activation (GO:0045916)2.96505288
35fatty acid elongation (GO:0030497)2.95276936
36lactate metabolic process (GO:0006089)2.92088299
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91429123
38L-phenylalanine catabolic process (GO:0006559)2.91429123
39negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.90253496
40glycerophospholipid catabolic process (GO:0046475)2.87735932
41phagosome maturation (GO:0090382)2.87188717
42presynaptic membrane assembly (GO:0097105)2.82879320
43macroautophagy (GO:0016236)2.82847617
44negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82611934
45regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81031543
46negative regulation of membrane potential (GO:0045837)2.80643155
47positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.80479131
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80354320
49tonic smooth muscle contraction (GO:0014820)2.79894212
50behavioral response to cocaine (GO:0048148)2.78968614
51artery smooth muscle contraction (GO:0014824)2.78752081
52peptide hormone processing (GO:0016486)2.76330288
53calcium-mediated signaling using intracellular calcium source (GO:0035584)2.75634257
54regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.74178785
55membrane assembly (GO:0071709)2.73904355
56nitric oxide mediated signal transduction (GO:0007263)2.72611015
57peptide hormone secretion (GO:0030072)2.72398509
58magnesium ion transport (GO:0015693)2.71632963
59neuron cell-cell adhesion (GO:0007158)2.69827956
60long-chain fatty acid biosynthetic process (GO:0042759)2.69631863
61peptide secretion (GO:0002790)2.69052343
62negative regulation of cation channel activity (GO:2001258)2.68869654
63detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.68470681
64detection of temperature stimulus involved in sensory perception (GO:0050961)2.68470681
65synaptic vesicle maturation (GO:0016188)2.67549916
66positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.67260543
67dopamine transport (GO:0015872)2.65741663
68regulation of synaptic vesicle transport (GO:1902803)2.64898956
69zinc ion homeostasis (GO:0055069)2.63582584
70positive regulation of insulin secretion (GO:0032024)2.63169852
71negative regulation of neurological system process (GO:0031645)2.61531181
72regulation of energy homeostasis (GO:2000505)2.61430954
73negative regulation of protein activation cascade (GO:2000258)2.61199886
74cellular zinc ion homeostasis (GO:0006882)2.59903440
75negative regulation of hormone biosynthetic process (GO:0032353)2.58388532
76negative regulation of neurotransmitter transport (GO:0051589)2.55937496
77water-soluble vitamin biosynthetic process (GO:0042364)2.55677737
78positive regulation of neurotransmitter transport (GO:0051590)2.53301684
79endosome to pigment granule transport (GO:0043485)2.53293290
80endosome to melanosome transport (GO:0035646)2.53293290
81neurotransmitter secretion (GO:0007269)2.53196762
82vascular smooth muscle contraction (GO:0014829)2.52931047
83zinc ion transport (GO:0006829)2.52335383
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.51600620
85presynaptic membrane organization (GO:0097090)2.51286773
86negative regulation of execution phase of apoptosis (GO:1900118)2.51256571
87regulation of metalloenzyme activity (GO:0048552)2.51023163
88sequestering of extracellular ligand from receptor (GO:0035581)2.50520234
89response to redox state (GO:0051775)2.50116608
90peptidyl-cysteine modification (GO:0018198)2.49404801
91negative regulation of dendrite development (GO:2000171)2.48038063
92zinc ion transmembrane transport (GO:0071577)2.46956573
93protein localization to synapse (GO:0035418)2.46865078
94proline transport (GO:0015824)2.46547031
95positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.44334810
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.44207133
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43361804
98neurofilament cytoskeleton organization (GO:0060052)2.43027374
99keratinocyte development (GO:0003334)2.42840366
100negative regulation of hormone metabolic process (GO:0032351)2.42208537
101negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.41527978
102vocalization behavior (GO:0071625)2.41466814
103long-term synaptic potentiation (GO:0060291)2.40327574
104regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40025263
105regulation of vesicle fusion (GO:0031338)2.39787951
106hormone secretion (GO:0046879)2.39702311
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39097515
108respiratory chain complex IV assembly (GO:0008535)2.38377923
109positive regulation of peptide hormone secretion (GO:0090277)2.37531384
110neuron-neuron synaptic transmission (GO:0007270)2.37471292
111long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.37017790
112regulation of voltage-gated calcium channel activity (GO:1901385)2.37014925
113nitric oxide biosynthetic process (GO:0006809)2.36389564
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.36252680
115cellular response to zinc ion (GO:0071294)2.35357458
116regulation of cell communication by electrical coupling (GO:0010649)2.33886605
117regulation of insulin secretion (GO:0050796)2.31555878
118positive regulation of meiosis (GO:0045836)2.31350112
119respiratory electron transport chain (GO:0022904)2.30832752
120ER overload response (GO:0006983)2.30551884
121regulation of axon regeneration (GO:0048679)2.30287560
122regulation of neuron projection regeneration (GO:0070570)2.30287560
123positive regulation of vesicle fusion (GO:0031340)2.30181902
124peptide transport (GO:0015833)2.30160816
125detection of temperature stimulus (GO:0016048)2.29546837
126hormone transport (GO:0009914)2.29376732
127positive regulation of peptide secretion (GO:0002793)2.29309354
128electron transport chain (GO:0022900)2.28795808
129phenol-containing compound catabolic process (GO:0019336)2.28254114
130negative regulation of acute inflammatory response (GO:0002674)2.26942800
131retinol metabolic process (GO:0042572)2.26115650
132gamma-aminobutyric acid signaling pathway (GO:0007214)2.24631675
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.24020007
134protein localization to cilium (GO:0061512)2.22983019
135intra-Golgi vesicle-mediated transport (GO:0006891)2.22927767
136aromatic amino acid family catabolic process (GO:0009074)2.22762230
137regulation of glutamate secretion (GO:0014048)2.22705185
138regulation of oxidative phosphorylation (GO:0002082)2.22587012
139serotonin receptor signaling pathway (GO:0007210)2.22388564
140regulation of neurotransmitter secretion (GO:0046928)2.22371485
141eosinophil chemotaxis (GO:0048245)2.21991193
142synaptic transmission, dopaminergic (GO:0001963)2.21702571
143vesicle transport along microtubule (GO:0047496)2.21691172
144regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.21411406
145regulation of amyloid precursor protein catabolic process (GO:1902991)2.20630989
146mannosylation (GO:0097502)2.20583448
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.20129088
148protein maturation by protein folding (GO:0022417)2.19800391
149regulation of protein autophosphorylation (GO:0031952)2.19070663
150negative regulation of glucose import (GO:0046325)2.17767378
151type B pancreatic cell development (GO:0003323)2.16567763
152protein neddylation (GO:0045116)2.16030344
153neurotransmitter transport (GO:0006836)2.15919287
154iron ion transport (GO:0006826)2.14317696
155regulation of memory T cell differentiation (GO:0043380)2.13784907
156positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.13359893
157regulation of neurotransmitter transport (GO:0051588)2.12768140
158positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.12734584
159positive regulation of muscle hypertrophy (GO:0014742)2.12368991
160positive regulation of cardiac muscle hypertrophy (GO:0010613)2.12368991
161positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.12154890
162pteridine-containing compound biosynthetic process (GO:0042559)2.11685873
163adenosine metabolic process (GO:0046085)2.11630583
164neuronal action potential (GO:0019228)2.11474067
165calcium ion-dependent exocytosis (GO:0017156)2.09879149
166cellular copper ion homeostasis (GO:0006878)2.09876085
167negative regulation of calcium ion transmembrane transport (GO:1903170)2.09019395
168negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.09019395
169response to cocaine (GO:0042220)2.08804975
170regulation of neuronal synaptic plasticity (GO:0048168)2.07290473
171regulation of excitatory postsynaptic membrane potential (GO:0060079)2.07198204
172regulation of synaptic transmission, glutamatergic (GO:0051966)2.06949716
173mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.06226368
174transmission of nerve impulse (GO:0019226)2.06200740
175positive regulation of mitochondrial fission (GO:0090141)2.05534387
176synaptic transmission, glutamatergic (GO:0035249)2.04352917
177regulation of long-term neuronal synaptic plasticity (GO:0048169)2.03783587
178regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.02641206
179negative regulation of neurotransmitter secretion (GO:0046929)2.02594348
180female mating behavior (GO:0060180)2.02468788
181cerebellar granule cell differentiation (GO:0021707)2.02084154
182neurotransmitter-gated ion channel clustering (GO:0072578)2.01655186
183regulation of dopamine secretion (GO:0014059)2.01634347
184substantia nigra development (GO:0021762)2.01534304
185fatty-acyl-CoA metabolic process (GO:0035337)2.01126102
186synaptic vesicle transport (GO:0048489)2.01105546
187establishment of synaptic vesicle localization (GO:0097480)2.01105546
188locomotory exploration behavior (GO:0035641)2.00494925
189establishment of vesicle localization (GO:0051650)2.00191991
190nucleotide transmembrane transport (GO:1901679)1.99287033
191detection of calcium ion (GO:0005513)1.98818407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.93623274
2GBX2_23144817_ChIP-Seq_PC3_Human3.26231512
3TAF15_26573619_Chip-Seq_HEK293_Human2.54607426
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47407896
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44957674
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35760000
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.31558603
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15392760
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13269853
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08580385
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02591696
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99973137
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97147823
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93407235
15NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93407235
16EZH2_22144423_ChIP-Seq_EOC_Human1.91432843
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90630989
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89078777
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89078777
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88974227
21AR_21572438_ChIP-Seq_LNCaP_Human1.87849972
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86914245
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86521613
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84891111
25P300_19829295_ChIP-Seq_ESCs_Human1.83547456
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.83309325
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81694418
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.81578913
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80786840
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76704946
31SMAD4_21799915_ChIP-Seq_A2780_Human1.74284069
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73289441
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71227619
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67944447
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.62343534
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.61691764
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60847991
38* EZH2_27304074_Chip-Seq_ESCs_Mouse1.60006941
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58169546
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57993028
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57627292
42VDR_22108803_ChIP-Seq_LS180_Human1.57422699
43* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55229894
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.54759070
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54545876
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54001927
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.53956778
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53003148
49ZNF274_21170338_ChIP-Seq_K562_Hela1.50735671
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50660247
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48618042
52TP53_18474530_ChIP-ChIP_U2OS_Human1.47973938
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43670772
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43592512
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.43146825
56AR_25329375_ChIP-Seq_VCAP_Human1.40845992
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.38568347
58* CDX2_22108803_ChIP-Seq_LS180_Human1.37836420
59ER_23166858_ChIP-Seq_MCF-7_Human1.37133052
60STAT3_18555785_Chip-Seq_ESCs_Mouse1.36296899
61IGF1R_20145208_ChIP-Seq_DFB_Human1.35380948
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.35314901
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.34350069
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34168505
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31219465
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29529439
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.27081576
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.26626959
69REST_21632747_ChIP-Seq_MESCs_Mouse1.26330643
70BCAT_22108803_ChIP-Seq_LS180_Human1.26289247
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.25739586
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.25097610
73HTT_18923047_ChIP-ChIP_STHdh_Human1.24124098
74CJUN_26792858_Chip-Seq_BT549_Human1.22282443
75BRD4_25478319_ChIP-Seq_HGPS_Human1.21856014
76FUS_26573619_Chip-Seq_HEK293_Human1.21160173
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20821704
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20722130
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19916482
80AHR_22903824_ChIP-Seq_MCF-7_Human1.19858969
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.18462866
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18100975
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17489547
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.17008396
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.15223299
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14488283
87SOX2_20726797_ChIP-Seq_SW620_Human1.14302624
88EWS_26573619_Chip-Seq_HEK293_Human1.14072031
89P300_18555785_Chip-Seq_ESCs_Mouse1.13010797
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12904944
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12764395
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12194170
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.11810663
94RXR_22108803_ChIP-Seq_LS180_Human1.11177309
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.10679796
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10375713
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.10280669
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.09426071
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.09089107
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09071044
101STAT3_23295773_ChIP-Seq_U87_Human1.08892066
102JUN_21703547_ChIP-Seq_K562_Human1.08797721
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08037302
104GATA1_22025678_ChIP-Seq_K562_Human1.07726473
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07197014
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06946630
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06865179
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.06251645
109CTCF_18555785_Chip-Seq_ESCs_Mouse1.04508116
110PU1_27457419_Chip-Seq_LIVER_Mouse1.03996005
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.03751377
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03751377
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03689262
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03206140
115RUNX2_22187159_ChIP-Seq_PCA_Human1.02402679
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01548921
117NANOG_19829295_ChIP-Seq_ESCs_Human1.01512961
118SOX2_19829295_ChIP-Seq_ESCs_Human1.01512961
119* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01326549
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01168017
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00804933
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00441320
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99867148
124TCF4_22108803_ChIP-Seq_LS180_Human0.99503323
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99312564
126CBP_20019798_ChIP-Seq_JUKART_Human0.99312564
127* CBX2_27304074_Chip-Seq_ESCs_Mouse0.98885195
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98854838
129KDM2B_26808549_Chip-Seq_REH_Human0.98394298
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97792798
131REST_18959480_ChIP-ChIP_MESCs_Mouse0.97385572
132DROSHA_22980978_ChIP-Seq_HELA_Human0.97155660
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96970379
134P53_22387025_ChIP-Seq_ESCs_Mouse0.96374658
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.95495397
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94550111
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93804323
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.93568922
139TP63_23658742_ChIP-Seq_EP156T_Human0.93527215
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92313788
141TCF4_23295773_ChIP-Seq_U87_Human0.91602775
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90549157
143TP53_16413492_ChIP-PET_HCT116_Human0.90201575
144RNF2_27304074_Chip-Seq_NSC_Mouse0.89443435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.50808464
2MP0004270_analgesia3.49679068
3MP0004859_abnormal_synaptic_plasticity3.14378715
4MP0001968_abnormal_touch/_nociception3.04869366
5MP0002735_abnormal_chemical_nociception2.82505878
6MP0002736_abnormal_nociception_after2.76961728
7MP0010386_abnormal_urinary_bladder2.67611435
8MP0002734_abnormal_mechanical_nocicepti2.51264990
9MP0009745_abnormal_behavioral_response2.40767720
10MP0003635_abnormal_synaptic_transmissio2.36876443
11MP0009046_muscle_twitch2.35096886
12MP0009780_abnormal_chondrocyte_physiolo2.33361343
13MP0006276_abnormal_autonomic_nervous2.26315787
14MP0002064_seizures2.25991808
15MP0006054_spinal_hemorrhage2.11810752
16MP0002272_abnormal_nervous_system2.09897187
17MP0001944_abnormal_pancreas_morphology2.07174241
18MP0002693_abnormal_pancreas_physiology2.06721055
19MP0002139_abnormal_hepatobiliary_system2.05197474
20MP0002822_catalepsy2.01387297
21MP0001501_abnormal_sleep_pattern2.00575946
22MP0001970_abnormal_pain_threshold1.99817845
23MP0003283_abnormal_digestive_organ1.99117877
24MP0002733_abnormal_thermal_nociception1.99078434
25MP0001984_abnormal_olfaction1.98427982
26MP0003950_abnormal_plasma_membrane1.98385678
27MP0002063_abnormal_learning/memory/cond1.93581895
28MP0006072_abnormal_retinal_apoptosis1.92498188
29MP0001905_abnormal_dopamine_level1.89277758
30MP0000569_abnormal_digit_pigmentation1.89064893
31MP0002572_abnormal_emotion/affect_behav1.84512521
32MP0003195_calcinosis1.79167932
33MP0010329_abnormal_lipoprotein_level1.73938424
34MP0005275_abnormal_skin_tensile1.67077327
35MP0001440_abnormal_grooming_behavior1.66842553
36MP0001756_abnormal_urination1.65904645
37MP0001986_abnormal_taste_sensitivity1.64574218
38MP0002876_abnormal_thyroid_physiology1.62984276
39MP0000013_abnormal_adipose_tissue1.59676425
40MP0002067_abnormal_sensory_capabilities1.58504769
41MP0005332_abnormal_amino_acid1.55759467
42MP0010678_abnormal_skin_adnexa1.53922632
43MP0003329_amyloid_beta_deposits1.48099415
44MP0010234_abnormal_vibrissa_follicle1.45074888
45MP0001486_abnormal_startle_reflex1.44732029
46MP0004858_abnormal_nervous_system1.42637636
47MP0005367_renal/urinary_system_phenotyp1.42359139
48MP0000516_abnormal_urinary_system1.42359139
49MP0001188_hyperpigmentation1.41144727
50MP0005174_abnormal_tail_pigmentation1.41081328
51MP0005171_absent_coat_pigmentation1.37634255
52MP0000920_abnormal_myelination1.35783139
53MP0002078_abnormal_glucose_homeostasis1.31893728
54MP0005646_abnormal_pituitary_gland1.28204761
55MP0004147_increased_porphyrin_level1.26998625
56MP0008877_abnormal_DNA_methylation1.25349151
57MP0004215_abnormal_myocardial_fiber1.25247352
58MP0008775_abnormal_heart_ventricle1.24430403
59MP0003183_abnormal_peptide_metabolism1.23699998
60MP0002837_dystrophic_cardiac_calcinosis1.22876530
61MP0004924_abnormal_behavior1.22529570
62MP0005386_behavior/neurological_phenoty1.22529570
63MP0005464_abnormal_platelet_physiology1.21968562
64MP0002102_abnormal_ear_morphology1.21415793
65MP0005645_abnormal_hypothalamus_physiol1.21218245
66MP0000372_irregular_coat_pigmentation1.21098943
67MP0001542_abnormal_bone_strength1.20800025
68MP0005551_abnormal_eye_electrophysiolog1.17873920
69MP0000015_abnormal_ear_pigmentation1.17643866
70MP0003172_abnormal_lysosome_physiology1.16649549
71MP0000003_abnormal_adipose_tissue1.16244004
72MP0003633_abnormal_nervous_system1.15714679
73MP0005253_abnormal_eye_physiology1.15684285
74MP0002909_abnormal_adrenal_gland1.14821380
75MP0002796_impaired_skin_barrier1.13404896
76MP0005075_abnormal_melanosome_morpholog1.12658586
77MP0004510_myositis1.12163272
78MP0003075_altered_response_to1.11930402
79MP0008004_abnormal_stomach_pH1.11179826
80MP0003690_abnormal_glial_cell1.10521845
81MP0004019_abnormal_vitamin_homeostasis1.09680342
82MP0001765_abnormal_ion_homeostasis1.09616814
83MP0002928_abnormal_bile_duct1.09471355
84MP0000639_abnormal_adrenal_gland1.07713262
85MP0002295_abnormal_pulmonary_circulatio1.07385316
86MP0000538_abnormal_urinary_bladder1.06611404
87MP0008875_abnormal_xenobiotic_pharmacok1.05721532
88MP0008569_lethality_at_weaning1.05350016
89MP0001529_abnormal_vocalization1.04853008
90MP0001177_atelectasis1.04666634
91MP0002184_abnormal_innervation1.04493812
92MP0008438_abnormal_cutaneous_collagen1.03421489
93MP0005636_abnormal_mineral_homeostasis1.03137331
94MP0004142_abnormal_muscle_tone1.02723519
95MP0005535_abnormal_body_temperature1.01897887
96MP0003186_abnormal_redox_activity1.00283707
97MP0001661_extended_life_span1.00229589
98MP0005165_increased_susceptibility_to1.00136609
99MP0003252_abnormal_bile_duct0.99650806
100MP0002638_abnormal_pupillary_reflex0.96700197
101MP0000604_amyloidosis0.96464884
102MP0003787_abnormal_imprinting0.96167939
103MP0003879_abnormal_hair_cell0.94749285
104MP0002254_reproductive_system_inflammat0.94492085
105MP0005448_abnormal_energy_balance0.94319924
106MP0005220_abnormal_exocrine_pancreas0.93498075
107MP0002938_white_spotting0.93202151
108MP0001299_abnormal_eye_distance/0.93063172
109MP0003631_nervous_system_phenotype0.91975494
110MP0004043_abnormal_pH_regulation0.91542408
111MP0003806_abnormal_nucleotide_metabolis0.91510267
112MP0000778_abnormal_nervous_system0.90129705
113MP0002066_abnormal_motor_capabilities/c0.89452408
114MP0008874_decreased_physiological_sensi0.89378457
115MP0009379_abnormal_foot_pigmentation0.89321366
116MP0009840_abnormal_foam_cell0.89153226
117MP0002166_altered_tumor_susceptibility0.89152729
118MP0003634_abnormal_glial_cell0.89078471
119MP0003953_abnormal_hormone_level0.88740465
120MP0002557_abnormal_social/conspecific_i0.88722826
121MP0005379_endocrine/exocrine_gland_phen0.88598688
122MP0002090_abnormal_vision0.88191411
123MP0003045_fibrosis0.88091877
124MP0000230_abnormal_systemic_arterial0.87021354
125MP0002118_abnormal_lipid_homeostasis0.85928212
126MP0004811_abnormal_neuron_physiology0.85906159
127MP0000955_abnormal_spinal_cord0.85582655
128MP0002006_tumorigenesis0.82282639
129MP0005503_abnormal_tendon_morphology0.82271509
130MP0006036_abnormal_mitochondrial_physio0.81899793
131MP0004742_abnormal_vestibular_system0.81295440
132MP0002882_abnormal_neuron_morphology0.81190830
133MP0003868_abnormal_feces_composition0.80791540
134MP0005164_abnormal_response_to0.80670980
135MP0001664_abnormal_digestion0.79971618
136MP0004484_altered_response_of0.79731117
137MP0002009_preneoplasia0.79678300
138MP0004272_abnormal_basement_membrane0.79546862
139MP0009643_abnormal_urine_homeostasis0.78803757
140MP0005365_abnormal_bile_salt0.78550220
141MP0002163_abnormal_gland_morphology0.78515811
142MP0005058_abnormal_lysosome_morphology0.78465983
143MP0003011_delayed_dark_adaptation0.78459961
144MP0002229_neurodegeneration0.78121070
145MP0010771_integument_phenotype0.78012711
146MP0000427_abnormal_hair_cycle0.76343874
147MP0002168_other_aberrant_phenotype0.75540987
148MP0004036_abnormal_muscle_relaxation0.72967055
149MP0005084_abnormal_gallbladder_morpholo0.69625023
150MP0008872_abnormal_physiological_respon0.68987998
151MP0004883_abnormal_blood_vessel0.68898747
152MP0004885_abnormal_endolymph0.68645784
153MP0001502_abnormal_circadian_rhythm0.67913983
154MP0001963_abnormal_hearing_physiology0.67418370
155MP0005623_abnormal_meninges_morphology0.66379825
156MP0004130_abnormal_muscle_cell0.65040557
157MP0004134_abnormal_chest_morphology0.63852507
158MP0002332_abnormal_exercise_endurance0.63593327
159MP0005595_abnormal_vascular_smooth0.63297682

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.78779798
2Atonic seizures (HP:0010819)4.42733077
3Myokymia (HP:0002411)4.14245337
4Hypothermia (HP:0002045)4.05227972
5Hypoglycemic coma (HP:0001325)4.01661139
6Hyperinsulinemic hypoglycemia (HP:0000825)3.73286034
7Ketoacidosis (HP:0001993)3.72642842
8Large for gestational age (HP:0001520)3.71492547
9Pheochromocytoma (HP:0002666)3.71311447
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68450876
11Neuroendocrine neoplasm (HP:0100634)3.66324520
12Hyperglycemia (HP:0003074)3.56079378
13Vascular calcification (HP:0004934)3.53884559
14Hypoglycemic seizures (HP:0002173)3.40465364
15Acute necrotizing encephalopathy (HP:0006965)3.38502905
16Cardiovascular calcification (HP:0011915)3.34212149
17Progressive macrocephaly (HP:0004481)3.16995660
18Abnormal mitochondria in muscle tissue (HP:0008316)3.11444767
19Febrile seizures (HP:0002373)2.97224155
20Focal seizures (HP:0007359)2.94709201
21Absence seizures (HP:0002121)2.89024787
22Insulin-resistant diabetes mellitus (HP:0000831)2.88020177
23Sensory axonal neuropathy (HP:0003390)2.87371624
24Insidious onset (HP:0003587)2.85719072
25Termporal pattern (HP:0011008)2.85719072
26Tongue fasciculations (HP:0001308)2.83857755
27Mitochondrial inheritance (HP:0001427)2.81987819
28Epileptic encephalopathy (HP:0200134)2.81897036
29Abnormality of vitamin B metabolism (HP:0004340)2.80078624
30Acute encephalopathy (HP:0006846)2.78366406
31Metaphyseal dysplasia (HP:0100255)2.77129646
32Renal cortical cysts (HP:0000803)2.70307035
33Ulnar claw (HP:0001178)2.69339743
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.68835506
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.68835506
36Hyperventilation (HP:0002883)2.67109164
37Progressive cerebellar ataxia (HP:0002073)2.62577986
38Dialeptic seizures (HP:0011146)2.57968029
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.57831918
40Stomatitis (HP:0010280)2.55303284
41Thyroiditis (HP:0100646)2.54392058
42Abnormality of the renal cortex (HP:0011035)2.53487490
43Autoamputation (HP:0001218)2.53453969
44Hematochezia (HP:0002573)2.52792774
45Action tremor (HP:0002345)2.45978366
46Generalized tonic-clonic seizures (HP:0002069)2.45881460
47Abnormality of the pancreatic islet cells (HP:0006476)2.43476514
48Abnormality of endocrine pancreas physiology (HP:0012093)2.43476514
49Visual hallucinations (HP:0002367)2.43199343
50Ketosis (HP:0001946)2.43089163
51Increased CSF protein (HP:0002922)2.41883558
52Albinism (HP:0001022)2.40888122
53Increased CSF lactate (HP:0002490)2.39943313
54Increased serum pyruvate (HP:0003542)2.38987293
55Abnormality of glycolysis (HP:0004366)2.38987293
56Cerebral hemorrhage (HP:0001342)2.38970236
57Hyperlipoproteinemia (HP:0010980)2.36247496
58Parakeratosis (HP:0001036)2.35249647
59Hemiparesis (HP:0001269)2.35023355
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30755092
61Abnormality of vitamin metabolism (HP:0100508)2.29737161
62Muscle fibrillation (HP:0010546)2.27113837
63Medial flaring of the eyebrow (HP:0010747)2.26798267
64Agitation (HP:0000713)2.26433275
65Symptomatic seizures (HP:0011145)2.25616628
66Intestinal atresia (HP:0011100)2.22912760
67Enlarged penis (HP:0000040)2.22876299
68Gait imbalance (HP:0002141)2.21429147
69Neurofibrillary tangles (HP:0002185)2.20327686
70Hepatocellular necrosis (HP:0001404)2.19717242
71Abnormality of methionine metabolism (HP:0010901)2.19086003
72Progressive inability to walk (HP:0002505)2.18539721
73Methylmalonic aciduria (HP:0012120)2.17248330
74Congenital primary aphakia (HP:0007707)2.16778690
75Proximal tubulopathy (HP:0000114)2.13776257
76Genital tract atresia (HP:0001827)2.13129234
77Abnormality of the corticospinal tract (HP:0002492)2.12397151
78Late onset (HP:0003584)2.12277608
79Anxiety (HP:0000739)2.12244743
80Epileptiform EEG discharges (HP:0011182)2.11534633
81Palpitations (HP:0001962)2.10305444
82Generalized aminoaciduria (HP:0002909)2.10071529
833-Methylglutaconic aciduria (HP:0003535)2.09618467
84Vaginal atresia (HP:0000148)2.09057340
85EEG with generalized epileptiform discharges (HP:0011198)2.08866971
86Hypomagnesemia (HP:0002917)2.07815053
87Limb dystonia (HP:0002451)2.07804201
88Vacuolated lymphocytes (HP:0001922)2.07683210
89Bone cyst (HP:0012062)2.07134756
90Nephrogenic diabetes insipidus (HP:0009806)2.04326749
91Abnormality of polysaccharide metabolism (HP:0011012)2.03227748
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03227748
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03227748
94Patchy hypopigmentation of hair (HP:0011365)2.03116838
95Scanning speech (HP:0002168)2.01803905
96Renal Fanconi syndrome (HP:0001994)2.00307113
97Conjunctival hamartoma (HP:0100780)1.99688809
98X-linked dominant inheritance (HP:0001423)1.99407153
99Retinal dysplasia (HP:0007973)1.98385731
100Congenital, generalized hypertrichosis (HP:0004540)1.98343934
101Cutaneous melanoma (HP:0012056)1.97526481
102Abnormal hair whorl (HP:0010721)1.96547854
103Testicular neoplasm (HP:0010788)1.93207623
104Abnormal eating behavior (HP:0100738)1.90470166
105Hamartoma of the eye (HP:0010568)1.90122559
106Petechiae (HP:0000967)1.89937847
107Arthropathy (HP:0003040)1.89895584
108Hypokinesia (HP:0002375)1.89880254
109Increased hepatocellular lipid droplets (HP:0006565)1.88051344
110Aplasia/Hypoplasia of the fovea (HP:0008060)1.87511346
111Hypoplasia of the fovea (HP:0007750)1.87511346
112Congenital ichthyosiform erythroderma (HP:0007431)1.86830495
113Pancreatic islet-cell hyperplasia (HP:0004510)1.86739023
114Abnormality of glycolipid metabolism (HP:0010969)1.86564616
115Abnormality of liposaccharide metabolism (HP:0010968)1.86564616
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.86564616
117Mucopolysacchariduria (HP:0008155)1.86364034
118Urinary glycosaminoglycan excretion (HP:0003541)1.86364034
119Abnormality of renal resorption (HP:0011038)1.85939151
120Hypoproteinemia (HP:0003075)1.85841803
121Cerebral edema (HP:0002181)1.85593442
122Hepatic necrosis (HP:0002605)1.85056339
123Hypsarrhythmia (HP:0002521)1.84971228
124Oligomenorrhea (HP:0000876)1.84939462
125Supranuclear gaze palsy (HP:0000605)1.84891759
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.84433587
127Furrowed tongue (HP:0000221)1.83719758
128Glycosuria (HP:0003076)1.81837952
129Abnormality of urine glucose concentration (HP:0011016)1.81837952
130Amblyopia (HP:0000646)1.81660045
131Glucose intolerance (HP:0000833)1.80423663
132Leukodystrophy (HP:0002415)1.80040142
133Aplasia involving bones of the upper limbs (HP:0009823)1.79926986
134Aplasia of the phalanges of the hand (HP:0009802)1.79926986
135Aplasia involving bones of the extremities (HP:0009825)1.79926986
136Truncal ataxia (HP:0002078)1.77062733
137Cerebral inclusion bodies (HP:0100314)1.76636065
138Abnormal pancreas size (HP:0012094)1.76616386
139Dysostosis multiplex (HP:0000943)1.76258238
140Bradycardia (HP:0001662)1.75926563
141Mutism (HP:0002300)1.74502255
142Hypoalbuminemia (HP:0003073)1.74302973
143Abnormal albumin level (HP:0012116)1.74302973
144Congenital stationary night blindness (HP:0007642)1.74248330
145Neoplasm of the peripheral nervous system (HP:0100007)1.73933241
146Onycholysis (HP:0001806)1.73902275
147Myotonia (HP:0002486)1.73611023
148Aplasia/hypoplasia of the uterus (HP:0008684)1.73433050
149Peripheral hypomyelination (HP:0007182)1.73229699
150Hyperphosphatemia (HP:0002905)1.73068214
151Akinesia (HP:0002304)1.71659400
152Postural tremor (HP:0002174)1.71634429
153Gaze-evoked nystagmus (HP:0000640)1.71598387
154Absent speech (HP:0001344)1.69464542
155Diminished movement (HP:0002374)1.69155938
156White forelock (HP:0002211)1.68591106
157Blue irides (HP:0000635)1.68546077
158Hypoventilation (HP:0002791)1.68276643
159Abnormality of the vocal cords (HP:0008777)1.67603036
160Abnormal gallbladder physiology (HP:0012438)1.66998122
161Cholecystitis (HP:0001082)1.66998122
162Lactic acidosis (HP:0003128)1.65991929
163Abnormal autonomic nervous system physiology (HP:0012332)1.65763970
164Methylmalonic acidemia (HP:0002912)1.64417572
165Respiratory failure (HP:0002878)1.64088190
166Optic disc pallor (HP:0000543)1.64025371
167Generalized myoclonic seizures (HP:0002123)1.63784798
168Lipid accumulation in hepatocytes (HP:0006561)1.63755844
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63673961
170Dysmetria (HP:0001310)1.63387009
171Delayed gross motor development (HP:0002194)1.63124291
172Torticollis (HP:0000473)1.62469267
173Ankle clonus (HP:0011448)1.62083275
174Failure to thrive in infancy (HP:0001531)1.61743718
175Poor suck (HP:0002033)1.61395361
176Polyphagia (HP:0002591)1.60796427
177Impaired pain sensation (HP:0007328)1.60694560
178Abnormality of pain sensation (HP:0010832)1.60694560
179Increased intramyocellular lipid droplets (HP:0012240)1.58998955
180Steppage gait (HP:0003376)1.57667955
181Hyperthyroidism (HP:0000836)1.55548082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.77224748
2MAP3K123.68867492
3MAP4K22.88820543
4NTRK32.39842215
5NTRK12.38360807
6MST42.32659406
7MAP2K72.28651592
8STK392.12263490
9OXSR12.11997923
10ARAF2.11934134
11GRK52.03695874
12MAP3K21.99622721
13TAOK31.93736802
14MINK11.90804791
15MAP3K41.89790732
16PLK21.88601977
17GRK11.87842978
18FRK1.86020779
19PHKG11.80302833
20RIPK41.80065072
21BMPR1B1.73807307
22BCR1.72296313
23TESK11.69703048
24ACVR1B1.64053546
25EPHA41.63554459
26MAP2K41.62834770
27MAPKAPK51.57836291
28FER1.54812454
29LIMK11.48707667
30FGFR31.48448981
31CDK191.47680642
32CAMKK21.47203077
33IRAK31.47152666
34SIK31.33574360
35MAP3K91.32370573
36DAPK21.31691997
37BMPR21.31628449
38TRIM281.30418252
39PRKCE1.26494396
40TNIK1.23033305
41MYLK1.21601807
42GRK71.19645375
43STK31.15730978
44SGK4941.15285218
45SGK2231.15285218
46WNK31.14861141
47PRPF4B1.12760133
48EIF2AK31.12084591
49NLK1.10758823
50KSR21.09843941
51WNK41.09693358
52PRKD31.08708733
53STK38L1.08488369
54MAP2K11.07793573
55PTK2B1.05033309
56MUSK1.02802569
57MAPK131.01470245
58CAMK2A0.97681511
59ADRBK20.96731123
60PDK20.96680200
61ERBB30.94215767
62SGK20.91506738
63CDK50.90961279
64CSNK1G20.89982592
65PAK30.87236115
66PRKCG0.83243396
67TRPM70.81808721
68AKT30.80198438
69PDK40.79978126
70PDK30.79978126
71LMTK20.79751467
72CSNK1G30.78915597
73CAMK2D0.78893567
74NME10.78530481
75MAP2K60.77753259
76CAMK2B0.77350530
77MST1R0.76451703
78MAP3K30.76075379
79INSRR0.75604547
80NUAK10.74084038
81PIK3CA0.73040619
82ADRBK10.72661099
83RET0.70941736
84MAP3K10.69933272
85CAMK2G0.69635643
86STK380.69471787
87ERBB40.66843849
88WNK10.66288673
89NEK60.64938310
90PBK0.64631895
91DAPK10.64083016
92PIM20.62626406
93CAMKK10.62137271
94PRKCH0.61907231
95MAPKAPK30.61621807
96IKBKB0.61432466
97JAK10.59494058
98STK240.58528810
99MATK0.58214542
100MET0.57101805
101TXK0.56937791
102EIF2AK10.56912024
103PLK30.56766714
104ROCK20.56030449
105PINK10.54842626
106HIPK20.53812173
107CSNK1G10.51205481
108PDPK10.49858368
109ILK0.49723162
110FGFR20.48822883
111EPHB20.48774282
112CDK140.48321714
113PAK60.47965174
114PASK0.47570856
115CSNK1A1L0.47332912
116TNK20.46756291
117PTK20.46162916
118SGK30.44118796
119GSK3A0.44098104
120FGR0.44097956
121TGFBR20.43934828
122FES0.42416152
123DDR20.42288575
124PRKACA0.42076612
125MOS0.40641857
126MAP3K140.40639603
127ABL20.40449060
128ROCK10.40251367
129EPHA30.39906498
130EPHB10.39660414
131PRKCQ0.38818256
132PHKG20.37299054
133PRKAA20.36589806
134NEK10.36102472
135PRKCI0.35182611
136TEC0.34667482
137PRKG10.33429322
138PRKCA0.33034035
139MKNK20.32623095
140DAPK30.30007959
141PIK3CG0.29421233
142SCYL20.26454196
143IKBKE0.26360880

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.18488895
2Collecting duct acid secretion_Homo sapiens_hsa049663.37108148
3Synaptic vesicle cycle_Homo sapiens_hsa047213.08962967
4Oxidative phosphorylation_Homo sapiens_hsa001902.76122314
5Vibrio cholerae infection_Homo sapiens_hsa051102.29830932
6Circadian rhythm_Homo sapiens_hsa047101.94422451
7Parkinsons disease_Homo sapiens_hsa050121.89413887
8Nicotine addiction_Homo sapiens_hsa050331.88785406
9Alzheimers disease_Homo sapiens_hsa050101.82918243
10Folate biosynthesis_Homo sapiens_hsa007901.77860691
11Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.73025662
12Rheumatoid arthritis_Homo sapiens_hsa053231.69399172
13Olfactory transduction_Homo sapiens_hsa047401.66343151
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66055358
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65534812
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64163959
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55900590
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55176703
19Serotonergic synapse_Homo sapiens_hsa047261.54828341
20Fatty acid elongation_Homo sapiens_hsa000621.54042386
21GABAergic synapse_Homo sapiens_hsa047271.50496890
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49485358
23Sulfur metabolism_Homo sapiens_hsa009201.47759598
24Circadian entrainment_Homo sapiens_hsa047131.46029333
25Amphetamine addiction_Homo sapiens_hsa050311.45192237
26Vitamin B6 metabolism_Homo sapiens_hsa007501.44459953
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.44443512
28Dopaminergic synapse_Homo sapiens_hsa047281.44277832
29Phagosome_Homo sapiens_hsa041451.38805282
30Morphine addiction_Homo sapiens_hsa050321.34801644
31Nitrogen metabolism_Homo sapiens_hsa009101.33177470
32Selenocompound metabolism_Homo sapiens_hsa004501.32204793
33Long-term potentiation_Homo sapiens_hsa047201.31583611
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31204882
35Glutamatergic synapse_Homo sapiens_hsa047241.29769095
36Taste transduction_Homo sapiens_hsa047421.29316567
37Renin secretion_Homo sapiens_hsa049241.26646361
38Salivary secretion_Homo sapiens_hsa049701.25274333
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24368829
40Cholinergic synapse_Homo sapiens_hsa047251.20525351
41Cocaine addiction_Homo sapiens_hsa050301.14806011
42Long-term depression_Homo sapiens_hsa047301.13992167
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13292570
44Insulin secretion_Homo sapiens_hsa049111.12337235
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09638744
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09411719
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09388922
48Tryptophan metabolism_Homo sapiens_hsa003801.08895090
49Gastric acid secretion_Homo sapiens_hsa049711.05966714
50Huntingtons disease_Homo sapiens_hsa050161.00684514
51Protein export_Homo sapiens_hsa030600.99068721
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97874287
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97552353
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96860295
55Steroid biosynthesis_Homo sapiens_hsa001000.91787284
56Pyruvate metabolism_Homo sapiens_hsa006200.90429682
57beta-Alanine metabolism_Homo sapiens_hsa004100.89622558
58Cardiac muscle contraction_Homo sapiens_hsa042600.88677896
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88225583
60Type I diabetes mellitus_Homo sapiens_hsa049400.86074453
61Calcium signaling pathway_Homo sapiens_hsa040200.84732824
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84187481
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83351711
64Sphingolipid metabolism_Homo sapiens_hsa006000.82556313
65Linoleic acid metabolism_Homo sapiens_hsa005910.81466411
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80111285
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78115509
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77807014
69GnRH signaling pathway_Homo sapiens_hsa049120.77166085
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76841798
71Glutathione metabolism_Homo sapiens_hsa004800.76645180
72Type II diabetes mellitus_Homo sapiens_hsa049300.76618554
73Arachidonic acid metabolism_Homo sapiens_hsa005900.76553056
74Oxytocin signaling pathway_Homo sapiens_hsa049210.76375650
75Butanoate metabolism_Homo sapiens_hsa006500.75092483
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74853915
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74840357
78Caffeine metabolism_Homo sapiens_hsa002320.74437380
79Proteasome_Homo sapiens_hsa030500.72133349
80Pancreatic secretion_Homo sapiens_hsa049720.70031916
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.69414756
82Axon guidance_Homo sapiens_hsa043600.67922879
83Phenylalanine metabolism_Homo sapiens_hsa003600.67495966
84Gap junction_Homo sapiens_hsa045400.66523658
85Propanoate metabolism_Homo sapiens_hsa006400.65187309
86Tyrosine metabolism_Homo sapiens_hsa003500.63941374
87Complement and coagulation cascades_Homo sapiens_hsa046100.63117964
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62466318
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61540762
90Ether lipid metabolism_Homo sapiens_hsa005650.61486636
91Lysosome_Homo sapiens_hsa041420.60969181
92Glucagon signaling pathway_Homo sapiens_hsa049220.59753278
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.59196520
94cAMP signaling pathway_Homo sapiens_hsa040240.57366539
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57011832
96Retinol metabolism_Homo sapiens_hsa008300.55976586
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55758587
98Dorso-ventral axis formation_Homo sapiens_hsa043200.55220311
99Histidine metabolism_Homo sapiens_hsa003400.53544967
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53376227
101Ras signaling pathway_Homo sapiens_hsa040140.52705732
102Chemical carcinogenesis_Homo sapiens_hsa052040.51451521
103Metabolic pathways_Homo sapiens_hsa011000.51377769
104Phototransduction_Homo sapiens_hsa047440.51194414
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50654681
106Fatty acid degradation_Homo sapiens_hsa000710.49940642
107Starch and sucrose metabolism_Homo sapiens_hsa005000.49842115
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49101102
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49019175
110Thyroid hormone synthesis_Homo sapiens_hsa049180.48691902
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48672582
112Melanogenesis_Homo sapiens_hsa049160.48250564
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47142841
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.46858674
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46548093
116ABC transporters_Homo sapiens_hsa020100.45233333
117Melanoma_Homo sapiens_hsa052180.45167206
118Fatty acid biosynthesis_Homo sapiens_hsa000610.44616693
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44216851
120N-Glycan biosynthesis_Homo sapiens_hsa005100.43823878
121Peroxisome_Homo sapiens_hsa041460.43774016
122ErbB signaling pathway_Homo sapiens_hsa040120.43678381
123Mineral absorption_Homo sapiens_hsa049780.43085861
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42913737
125African trypanosomiasis_Homo sapiens_hsa051430.41926434
126Basal transcription factors_Homo sapiens_hsa030220.41324613
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40831950
128Salmonella infection_Homo sapiens_hsa051320.40773673
129Ovarian steroidogenesis_Homo sapiens_hsa049130.40616190
130Fatty acid metabolism_Homo sapiens_hsa012120.40243892
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39815797
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39430584
133Glioma_Homo sapiens_hsa052140.37582519
134Estrogen signaling pathway_Homo sapiens_hsa049150.37246155
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35884251
136Legionellosis_Homo sapiens_hsa051340.35103581
137Regulation of autophagy_Homo sapiens_hsa041400.35054174
138Endocytosis_Homo sapiens_hsa041440.33877999
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31405729
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30851182
141Pertussis_Homo sapiens_hsa051330.30219600

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