DYRK1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)4.94879519
2daunorubicin metabolic process (GO:0044597)4.94879519
3polyketide metabolic process (GO:0030638)4.94879519
4nuclear pore complex assembly (GO:0051292)4.81684775
5regulation of telomere maintenance via telomerase (GO:0032210)4.77578482
6regulation of nuclear cell cycle DNA replication (GO:0033262)4.57513151
7protein localization to kinetochore (GO:0034501)4.52852058
8nuclear pore organization (GO:0006999)4.34295403
9mitotic sister chromatid segregation (GO:0000070)4.27182369
10positive regulation of gamma-delta T cell activation (GO:0046645)4.25986944
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.24861067
12sister chromatid segregation (GO:0000819)4.12822834
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.01696696
14interferon-gamma production (GO:0032609)4.01026053
15histone H4-K12 acetylation (GO:0043983)3.99118479
16histone H4-K5 acetylation (GO:0043981)3.97379697
17histone H4-K8 acetylation (GO:0043982)3.97379697
18negative regulation of cell cycle G2/M phase transition (GO:1902750)3.95087303
19regulation of B cell receptor signaling pathway (GO:0050855)3.83367802
20interkinetic nuclear migration (GO:0022027)3.82056150
21protein localization to chromosome, centromeric region (GO:0071459)3.79073317
22positive regulation of DNA-dependent DNA replication (GO:2000105)3.74963883
23negative regulation of erythrocyte differentiation (GO:0045647)3.71553146
24definitive hemopoiesis (GO:0060216)3.70264140
25pore complex assembly (GO:0046931)3.63211506
26monoubiquitinated protein deubiquitination (GO:0035520)3.59059821
27histone H3-K9 demethylation (GO:0033169)3.51865012
28somite rostral/caudal axis specification (GO:0032525)3.51454257
29pre-miRNA processing (GO:0031054)3.50863351
30mitotic chromosome condensation (GO:0007076)3.49539475
31B cell receptor signaling pathway (GO:0050853)3.44608484
32regulation of telomere maintenance (GO:0032204)3.43325185
33mRNA stabilization (GO:0048255)3.43126148
34RNA stabilization (GO:0043489)3.43126148
35histone H4-K16 acetylation (GO:0043984)3.41841961
36notochord development (GO:0030903)3.41318414
37regulation of gamma-delta T cell differentiation (GO:0045586)3.40686344
38regulation of gamma-delta T cell activation (GO:0046643)3.36112858
39histone H3-K4 methylation (GO:0051568)3.35822262
40maintenance of protein location in nucleus (GO:0051457)3.34831671
41nerve growth factor signaling pathway (GO:0038180)3.31861798
42regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31591759
43negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.28518473
44chromatin assembly (GO:0031497)3.26808373
45mitotic sister chromatid cohesion (GO:0007064)3.19092711
46embryonic process involved in female pregnancy (GO:0060136)3.14463764
47DNA replication checkpoint (GO:0000076)3.12409454
48regulation of NFAT protein import into nucleus (GO:0051532)3.07056961
49negative regulation of epidermis development (GO:0045683)3.06851702
50positive T cell selection (GO:0043368)3.06467417
51regulation of double-strand break repair (GO:2000779)3.05212305
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04796350
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03708058
54heterochromatin organization (GO:0070828)3.02584097
55negative regulation of telomerase activity (GO:0051974)2.99398770
56regulation of RNA export from nucleus (GO:0046831)2.98322840
57response to muramyl dipeptide (GO:0032495)2.97185986
58regulation of MHC class I biosynthetic process (GO:0045343)2.96349813
59negative regulation of telomere maintenance (GO:0032205)2.95035571
60dosage compensation (GO:0007549)2.94619569
61germinal center formation (GO:0002467)2.93961075
62positive regulation of granulocyte differentiation (GO:0030854)2.91950860
63NLS-bearing protein import into nucleus (GO:0006607)2.89629089
64* peptidyl-threonine phosphorylation (GO:0018107)2.88571268
65positive thymic T cell selection (GO:0045059)2.85511319
66nucleus localization (GO:0051647)2.82179663
67muscle organ morphogenesis (GO:0048644)2.79305001
68cellular response to ethanol (GO:0071361)2.73225412
69regulation of DNA-dependent DNA replication (GO:0090329)2.73119161
70aminoglycoside antibiotic metabolic process (GO:0030647)2.71477817
71regulation of nucleobase-containing compound transport (GO:0032239)2.69422374
72* peptidyl-threonine modification (GO:0018210)2.69370906
73peptidyl-lysine trimethylation (GO:0018023)2.68938686
74protein localization to chromosome (GO:0034502)2.68857509
75positive regulation of Rap GTPase activity (GO:0032854)2.67257127
76negative thymic T cell selection (GO:0045060)2.66970811
77rRNA transcription (GO:0009303)2.64898370
78positive regulation of cellular amide metabolic process (GO:0034250)2.63837710
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63761430
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.63761430
81modulation by symbiont of host immune response (GO:0052553)2.63761430
82positive regulation by symbiont of host defense response (GO:0052509)2.63761430
83modulation by symbiont of host defense response (GO:0052031)2.63761430
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63761430
85negative T cell selection (GO:0043383)2.62866644
86cytidine deamination (GO:0009972)2.62546166
87cytidine metabolic process (GO:0046087)2.62546166
88cytidine catabolic process (GO:0006216)2.62546166
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62379780
90negative regulation of translation, ncRNA-mediated (GO:0040033)2.62379780
91regulation of translation, ncRNA-mediated (GO:0045974)2.62379780
92DNA duplex unwinding (GO:0032508)2.61801237
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61345742
94macrophage activation involved in immune response (GO:0002281)2.59173116
95DNA geometric change (GO:0032392)2.58733663
96positive regulation of B cell differentiation (GO:0045579)2.58500509
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57590721
98regulation of G0 to G1 transition (GO:0070316)2.57140432
99regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.56315278
100regulation of histone H3-K9 methylation (GO:0051570)2.55627711
101negative regulation of histone methylation (GO:0031061)2.55240535
102histone H3-K4 trimethylation (GO:0080182)2.54476817
103rRNA methylation (GO:0031167)2.53806599
104cellular extravasation (GO:0045123)2.52586437
105negative regulation of phagocytosis (GO:0050765)2.51824162
106histone H3-K36 demethylation (GO:0070544)2.51351017
107regulation of pigment cell differentiation (GO:0050932)2.50280315
108histone H3-K9 modification (GO:0061647)2.48384888
109positive regulation of gene expression, epigenetic (GO:0045815)2.48272706
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48129853
111DNA replication-dependent nucleosome assembly (GO:0006335)2.47834341
112DNA replication-dependent nucleosome organization (GO:0034723)2.47834341
113histone lysine demethylation (GO:0070076)2.47041977
114histone demethylation (GO:0016577)2.46484774
115mitotic nuclear envelope disassembly (GO:0007077)2.44743496
116regulation of response to osmotic stress (GO:0047484)2.44504139
117B cell homeostasis (GO:0001782)2.44332171
118positive regulation of histone deacetylation (GO:0031065)2.43959372
119detection of molecule of bacterial origin (GO:0032490)2.43648222
120mitochondrion distribution (GO:0048311)2.43647922
121trophectodermal cell differentiation (GO:0001829)2.43169969
122negative regulation of chromatin modification (GO:1903309)2.43140056
123regulation of Rap GTPase activity (GO:0032317)2.42533088
124intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.41310233
125T cell selection (GO:0045058)2.41240648
126corticosteroid receptor signaling pathway (GO:0031958)2.40674666
127cytoplasmic mRNA processing body assembly (GO:0033962)2.40513917
128embryonic camera-type eye morphogenesis (GO:0048596)2.39475318
129negative regulation of DNA repair (GO:0045738)2.39429619
130detection of other organism (GO:0098543)2.37521219
131histone H4 acetylation (GO:0043967)2.37435703
132negative regulation of epidermal cell differentiation (GO:0045605)2.37132712
133regulation of translation in response to stress (GO:0043555)2.37080320
134regulation of mRNA stability (GO:0043488)2.36712579
135phospholipid translocation (GO:0045332)2.36247108
136lipid translocation (GO:0034204)2.36247108
137regulation of ARF protein signal transduction (GO:0032012)2.35966891
1383-UTR-mediated mRNA stabilization (GO:0070935)2.35866395
139regulation of hippo signaling (GO:0035330)2.35597682
140regulation of B cell differentiation (GO:0045577)2.35100745
141regulation of necroptotic process (GO:0060544)2.34870685
142mitotic G2/M transition checkpoint (GO:0044818)2.34779677
143mitotic metaphase plate congression (GO:0007080)2.34768865
144glucocorticoid receptor signaling pathway (GO:0042921)2.34661308
145negative regulation of histone modification (GO:0031057)2.34356069
146regulation of protein polyubiquitination (GO:1902914)2.34290744
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33887971
148negative regulation of cell killing (GO:0031342)2.33887971
149membrane disassembly (GO:0030397)2.33526048
150nuclear envelope disassembly (GO:0051081)2.33526048
151regulation of double-strand break repair via homologous recombination (GO:0010569)2.33251303
152negative regulation of potassium ion transmembrane transport (GO:1901380)2.32440978
153establishment of nucleus localization (GO:0040023)2.32075957
154positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.31941855
155DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.31852254
156sister chromatid cohesion (GO:0007062)2.31839070
157response to peptidoglycan (GO:0032494)2.30911509
158histone lysine methylation (GO:0034968)2.29910252
159negative regulation of T cell mediated immunity (GO:0002710)2.29830806
160mature B cell differentiation (GO:0002335)2.29679747
161negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.29023374
162negative regulation of T-helper cell differentiation (GO:0045623)2.29023374
163chromosome segregation (GO:0007059)2.28835900
164protein K48-linked deubiquitination (GO:0071108)2.28696120
165protein-DNA complex disassembly (GO:0032986)2.28419453
166nucleosome disassembly (GO:0006337)2.28419453
167protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.26251671
168protein demethylation (GO:0006482)2.25827830
169protein dealkylation (GO:0008214)2.25827830
170megakaryocyte development (GO:0035855)2.24290295
171thymic T cell selection (GO:0045061)2.22527324
172T cell migration (GO:0072678)2.21336235
173cellular response to nerve growth factor stimulus (GO:1990090)2.19430030
174response to nerve growth factor (GO:1990089)2.19430030
175N-terminal protein amino acid acetylation (GO:0006474)2.18250013
176hypotonic response (GO:0006971)2.17033152
177Rap protein signal transduction (GO:0032486)2.16396583
178negative regulation of lymphocyte mediated immunity (GO:0002707)2.16216004
179response to host immune response (GO:0052572)2.15834844
180response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.15834844
181positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.15340521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31479946
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.72604675
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.50631409
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.50631409
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.50631409
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.37231706
7FOXM1_23109430_ChIP-Seq_U2OS_Human4.22064586
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.63704910
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56866464
10GATA1_22025678_ChIP-Seq_K562_Human2.93790929
11MYC_22102868_ChIP-Seq_BL_Human2.53622991
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45630032
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.42822756
14* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41413656
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.28130536
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27099850
17* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20569358
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.16573953
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14385430
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11199548
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08428257
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.04098405
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.01057505
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99389788
25SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90897511
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89631890
27VDR_24787735_ChIP-Seq_THP-1_Human1.87657110
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86783729
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86628510
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86544771
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86392690
32TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86155361
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.84161418
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79352010
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.75613440
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75602857
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.74083201
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70282140
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.68265313
40NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64968320
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59471162
42VDR_24763502_ChIP-Seq_THP-1_Human1.56179850
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56076019
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54425282
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54323356
46* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51458792
47TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.47499981
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45849964
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42317533
50* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42274780
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41550957
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40774604
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40263914
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.39948830
55GATA1_19941826_ChIP-Seq_K562_Human1.37334194
56EZH2_22144423_ChIP-Seq_EOC_Human1.36370612
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35128745
58VDR_21846776_ChIP-Seq_THP-1_Human1.35120372
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32530753
60CIITA_25753668_ChIP-Seq_RAJI_Human1.30696474
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29795787
62SPI1_23127762_ChIP-Seq_K562_Human1.29780048
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28185691
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28177531
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26703070
66PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.24586425
67* GATA2_19941826_ChIP-Seq_K562_Human1.23791222
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23480197
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22368458
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.21593195
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20039022
72AHR_22903824_ChIP-Seq_MCF-7_Human1.19927390
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19917279
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17165016
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.16784732
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16528730
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16244566
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16160787
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15883814
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15116233
81AR_21572438_ChIP-Seq_LNCaP_Human1.15088750
82SCL_19346495_ChIP-Seq_HPC-7_Human1.12962250
83* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12433495
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.11055894
85* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10832976
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09715718
87* PU_27001747_Chip-Seq_BMDM_Mouse1.09676590
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09664687
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.09589622
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09506556
91* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09302605
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07156095
93* GATA1_19941827_ChIP-Seq_MEL_Mouse1.06475778
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06135766
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05878543
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05530132
97* NCOR1_26117541_ChIP-Seq_K562_Human1.05521650
98MYB_26560356_Chip-Seq_TH1_Human1.05460402
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05188982
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05122482
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03365537
102POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03293189
103TP53_16413492_ChIP-PET_HCT116_Human1.02740867
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02358689
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02355748
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.02216548
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01352850
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.01063371
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00138756
110POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99728487
111MYB_26560356_Chip-Seq_TH2_Human0.99654015
112* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99357133
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99037011
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98967114
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98967114
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98761546
117STAT3_23295773_ChIP-Seq_U87_Human0.98093756
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97684090
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97635201
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96988751
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.96022984
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95978720
123* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95732656
124IRF8_21731497_ChIP-ChIP_J774_Mouse0.95710771
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95384990
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94502123
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94169713
128KDM2B_26808549_Chip-Seq_DND41_Human0.93402264
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93352067
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.92626737
131NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91952097
132RNF2_27304074_Chip-Seq_NSC_Mouse0.91385904
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91171696
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91017344
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.90901597
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90422524
137IRF1_19129219_ChIP-ChIP_H3396_Human0.90091898
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.89998293
139* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88876353
140RUNX_20019798_ChIP-Seq_JUKART_Human0.88512995
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88319832
142SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87651233
143POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87484657
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.87282023
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87196326
146KDM2B_26808549_Chip-Seq_K562_Human0.86508412
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.86129865
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.85802566
149NANOG_16518401_ChIP-PET_MESCs_Mouse0.85748293
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85031539
151YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85020364
152* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85007526
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84280444
154RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81293392
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80264152
156UTX_26944678_Chip-Seq_JUKART_Human0.79548637
157SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77536063
158E2F1_17053090_ChIP-ChIP_MCF-7_Human0.75512121
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74662272
160BRD4_25478319_ChIP-Seq_HGPS_Human0.74426723
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73580875
162* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.73429550
163MAF_26560356_Chip-Seq_TH1_Human0.73192345
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.72662099
165CDX2_20551321_ChIP-Seq_CACO-2_Human0.72205033
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.71861950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.00780670
2MP0006292_abnormal_olfactory_placode3.23318682
3MP0003787_abnormal_imprinting3.11724996
4MP0003303_peritoneal_inflammation3.05501695
5MP0003121_genomic_imprinting2.77495268
6MP0005394_taste/olfaction_phenotype2.65618261
7MP0005499_abnormal_olfactory_system2.65618261
8MP0002166_altered_tumor_susceptibility2.58043791
9MP0003890_abnormal_embryonic-extraembry2.52357118
10MP0008057_abnormal_DNA_replication2.46660977
11MP0004264_abnormal_extraembryonic_tissu2.45047632
12MP0005409_darkened_coat_color2.35970277
13MP0003122_maternal_imprinting2.27288592
14MP0003300_gastrointestinal_ulcer2.25612055
15MP0010352_gastrointestinal_tract_polyps2.17847434
16MP0002877_abnormal_melanocyte_morpholog2.13991028
17MP0010094_abnormal_chromosome_stability1.98655781
18MP0004957_abnormal_blastocyst_morpholog1.95232181
19MP0008877_abnormal_DNA_methylation1.93164430
20MP0003656_abnormal_erythrocyte_physiolo1.91862687
21MP0003091_abnormal_cell_migration1.89730817
22MP0005075_abnormal_melanosome_morpholog1.84951899
23MP0003077_abnormal_cell_cycle1.83480829
24MP0003724_increased_susceptibility_to1.80381549
25MP0003221_abnormal_cardiomyocyte_apopto1.77102031
26MP0005451_abnormal_body_composition1.76981909
27MP0005248_abnormal_Harderian_gland1.76127444
28MP0008789_abnormal_olfactory_epithelium1.75513477
29MP0003045_fibrosis1.71905610
30* MP0001672_abnormal_embryogenesis/_devel1.70741834
31* MP0005380_embryogenesis_phenotype1.70741834
32MP0003111_abnormal_nucleus_morphology1.69831965
33MP0005397_hematopoietic_system_phenotyp1.67853515
34MP0001545_abnormal_hematopoietic_system1.67853515
35MP0000350_abnormal_cell_proliferation1.67064012
36MP0005076_abnormal_cell_differentiation1.65247248
37MP0002006_tumorigenesis1.64283198
38MP0008007_abnormal_cellular_replicative1.63002979
39* MP0003984_embryonic_growth_retardation1.62726930
40* MP0002088_abnormal_embryonic_growth/wei1.62696981
41MP0004130_abnormal_muscle_cell1.61545605
42MP0002254_reproductive_system_inflammat1.55563770
43MP0009278_abnormal_bone_marrow1.51781485
44MP0003436_decreased_susceptibility_to1.50514172
45MP0003123_paternal_imprinting1.49208466
46MP0004858_abnormal_nervous_system1.47390265
47MP0004381_abnormal_hair_follicle1.47242252
48MP0004947_skin_inflammation1.47221285
49MP0002396_abnormal_hematopoietic_system1.44894706
50MP0003828_pulmonary_edema1.43848897
51MP0000685_abnormal_immune_system1.43376653
52MP0004484_altered_response_of1.42697711
53MP0001851_eye_inflammation1.41668377
54MP0002653_abnormal_ependyma_morphology1.41079673
55MP0001293_anophthalmia1.40686847
56MP0002086_abnormal_extraembryonic_tissu1.40608727
57MP0000015_abnormal_ear_pigmentation1.40603533
58MP0004808_abnormal_hematopoietic_stem1.40168894
59MP0002420_abnormal_adaptive_immunity1.39276534
60MP0003693_abnormal_embryo_hatching1.38727734
61MP0002405_respiratory_system_inflammati1.38323773
62MP0004185_abnormal_adipocyte_glucose1.38257845
63MP0005257_abnormal_intraocular_pressure1.35697205
64MP0001819_abnormal_immune_cell1.34968823
65MP0002332_abnormal_exercise_endurance1.34764481
66MP0005387_immune_system_phenotype1.32751481
67MP0001790_abnormal_immune_system1.32751481
68MP0005000_abnormal_immune_tolerance1.32719491
69MP0003705_abnormal_hypodermis_morpholog1.31829758
70MP0000716_abnormal_immune_system1.30235392
71MP0004036_abnormal_muscle_relaxation1.30018676
72MP0002452_abnormal_antigen_presenting1.29945283
73MP0002723_abnormal_immune_serum1.29510260
74MP0005666_abnormal_adipose_tissue1.28102972
75MP0002127_abnormal_cardiovascular_syste1.26975750
76MP0004510_myositis1.25521974
77MP0002085_abnormal_embryonic_tissue1.25417565
78MP0002419_abnormal_innate_immunity1.24507863
79MP0003935_abnormal_craniofacial_develop1.24179882
80MP0005464_abnormal_platelet_physiology1.24144201
81MP0005174_abnormal_tail_pigmentation1.23546766
82MP0003763_abnormal_thymus_physiology1.22860796
83MP0004197_abnormal_fetal_growth/weight/1.22399239
84MP0002009_preneoplasia1.21203398
85MP0003011_delayed_dark_adaptation1.19236034
86MP0010307_abnormal_tumor_latency1.18148098
87MP0003755_abnormal_palate_morphology1.16625669
88MP0002084_abnormal_developmental_patter1.10846937
89MP0008260_abnormal_autophagy1.09773020
90MP0000465_gastrointestinal_hemorrhage1.08814627
91MP0010030_abnormal_orbit_morphology1.08367072
92MP0002233_abnormal_nose_morphology1.07825883
93MP0002925_abnormal_cardiovascular_devel1.07389685
94MP0004084_abnormal_cardiac_muscle1.06924684
95MP0009115_abnormal_fat_cell1.06576190
96MP0003938_abnormal_ear_development1.05232459
97MP0002092_abnormal_eye_morphology1.05004971
98MP0003690_abnormal_glial_cell1.04363483
99MP0000428_abnormal_craniofacial_morphol1.03101651
100* MP0000432_abnormal_head_morphology1.02980990
101MP0001730_embryonic_growth_arrest1.02423164
102MP0002132_abnormal_respiratory_system1.02100444
103MP0005025_abnormal_response_to1.01358199
104MP0002998_abnormal_bone_remodeling1.00921785
105MP0000516_abnormal_urinary_system1.00551757
106MP0005367_renal/urinary_system_phenotyp1.00551757
107MP0009703_decreased_birth_body0.99748267
108MP0000490_abnormal_crypts_of0.99282343
109MP0002429_abnormal_blood_cell0.97958236
110* MP0001697_abnormal_embryo_size0.97609591
111MP0003183_abnormal_peptide_metabolism0.96735532
112MP0000678_abnormal_parathyroid_gland0.96631531
113MP0002277_abnormal_respiratory_mucosa0.96082722
114MP0000703_abnormal_thymus_morphology0.95241740
115MP0000313_abnormal_cell_death0.94835320
116MP0002398_abnormal_bone_marrow0.94072652
117MP0010630_abnormal_cardiac_muscle0.93717703
118MP0003567_abnormal_fetal_cardiomyocyte0.92961618
119MP0000049_abnormal_middle_ear0.92211252
120MP0000759_abnormal_skeletal_muscle0.91937478
121MP0001286_abnormal_eye_development0.91734667
122MP0003646_muscle_fatigue0.91225289
123MP0002114_abnormal_axial_skeleton0.90759808
124MP0002106_abnormal_muscle_physiology0.90674133
125MP0008961_abnormal_basal_metabolism0.90525762
126MP0008058_abnormal_DNA_repair0.90299881
127MP0005375_adipose_tissue_phenotype0.90222513
128MP0000749_muscle_degeneration0.89142201
129MP0005621_abnormal_cell_physiology0.88343362
130MP0010678_abnormal_skin_adnexa0.88060152
131MP0005310_abnormal_salivary_gland0.87952360
132MP0010234_abnormal_vibrissa_follicle0.87240334
133MP0008932_abnormal_embryonic_tissue0.85253401
134MP0003937_abnormal_limbs/digits/tail_de0.84271724
135MP0003119_abnormal_digestive_system0.84264671
136MP0002116_abnormal_craniofacial_bone0.83925640
137MP0000733_abnormal_muscle_development0.83678265
138MP0005671_abnormal_response_to0.83246312
139MP0003448_altered_tumor_morphology0.83111786
140MP0008004_abnormal_stomach_pH0.82898220
141MP0003866_abnormal_defecation0.82013758
142MP0003786_premature_aging0.81709213
143* MP0002080_prenatal_lethality0.80802130
144MP0000383_abnormal_hair_follicle0.80567260
145MP0002932_abnormal_joint_morphology0.79872567
146MP0001835_abnormal_antigen_presentation0.78488722
147MP0001784_abnormal_fluid_regulation0.78134600
148MP0010155_abnormal_intestine_physiology0.76874272
149MP0002081_perinatal_lethality0.75627692
150MP0003453_abnormal_keratinocyte_physiol0.75298581
151MP0002722_abnormal_immune_system0.74626407
152MP0000689_abnormal_spleen_morphology0.74018312
153* MP0000266_abnormal_heart_morphology0.73920133
154MP0000767_abnormal_smooth_muscle0.73807772
155MP0005197_abnormal_uvea_morphology0.73775410
156MP0006138_congestive_heart_failure0.72542919
157MP0001915_intracranial_hemorrhage0.72096635
158MP0001849_ear_inflammation0.72037904
159MP0002971_abnormal_brown_adipose0.71614341
160MP0002019_abnormal_tumor_incidence0.70947653
161MP0001879_abnormal_lymphatic_vessel0.70909221
162MP0001800_abnormal_humoral_immune0.70874905
163MP0006035_abnormal_mitochondrial_morpho0.70664375
164MP0004087_abnormal_muscle_fiber0.70534782
165MP0008569_lethality_at_weaning0.67763199
166MP0002133_abnormal_respiratory_system0.67703070
167MP0005388_respiratory_system_phenotype0.67703070
168MP0005369_muscle_phenotype0.67549076

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.18794749
2Hypochromic microcytic anemia (HP:0004840)4.14154475
3Hepatoblastoma (HP:0002884)3.88477314
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69279912
5Chromsome breakage (HP:0040012)3.42305209
6Abnormality of the left ventricular outflow tract (HP:0011103)3.32557377
7Subaortic stenosis (HP:0001682)3.32557377
8Abnormality of the fingertips (HP:0001211)3.23196050
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.20922954
10Rib fusion (HP:0000902)3.14299167
11Nephroblastoma (Wilms tumor) (HP:0002667)3.05563321
12Acute myeloid leukemia (HP:0004808)3.02215405
13T lymphocytopenia (HP:0005403)2.98778769
14Spontaneous hematomas (HP:0007420)2.97421276
15Dysmetric saccades (HP:0000641)2.96974019
16Eczematoid dermatitis (HP:0000976)2.96875346
17Embryonal renal neoplasm (HP:0011794)2.83311353
18Volvulus (HP:0002580)2.83074977
19Truncal obesity (HP:0001956)2.76512643
20Absent frontal sinuses (HP:0002688)2.73412320
21Intestinal fistula (HP:0100819)2.71538429
22Rhabdomyosarcoma (HP:0002859)2.71180147
23Difficulty running (HP:0009046)2.62960957
24Abnormal lung lobation (HP:0002101)2.56524673
25Abnormality of chromosome segregation (HP:0002916)2.56180668
26Abnormality of T cell number (HP:0011839)2.55368063
27Abnormality of the phalanges of the hallux (HP:0010057)2.54600761
28Colitis (HP:0002583)2.54059052
29Exercise-induced myalgia (HP:0003738)2.51913131
30Genetic anticipation (HP:0003743)2.51703491
31Papillary thyroid carcinoma (HP:0002895)2.50784326
32Shawl scrotum (HP:0000049)2.49304365
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.47639216
34Recurrent bacterial skin infections (HP:0005406)2.46450585
35Periauricular skin pits (HP:0100277)2.45596844
36Preauricular pit (HP:0004467)2.45596844
37Recurrent viral infections (HP:0004429)2.44599129
38Abnormality of the lower motor neuron (HP:0002366)2.43879038
39Impulsivity (HP:0100710)2.43005000
40Neoplasm of striated muscle (HP:0009728)2.42760040
41Ependymoma (HP:0002888)2.38559223
42Hyporeflexia of lower limbs (HP:0002600)2.33307973
43Narrow palate (HP:0000189)2.32318749
44Viral hepatitis (HP:0006562)2.31691264
45Meckel diverticulum (HP:0002245)2.31465795
46Neonatal hypoglycemia (HP:0001998)2.31441783
47Abnormality of the intervertebral disk (HP:0005108)2.30573449
48Astrocytoma (HP:0009592)2.30276827
49Abnormality of the astrocytes (HP:0100707)2.30276827
50Rectovaginal fistula (HP:0000143)2.29044698
51Rectal fistula (HP:0100590)2.29044698
52Hypoplasia of the fovea (HP:0007750)2.24555725
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.24555725
54Hypochromic anemia (HP:0001931)2.24490254
55Hyperkalemia (HP:0002153)2.20281871
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.19791458
57Relative macrocephaly (HP:0004482)2.19058768
58Heterotopia (HP:0002282)2.15838401
59Recurrent abscess formation (HP:0002722)2.15480064
60Panhypogammaglobulinemia (HP:0003139)2.15220526
61Dislocated radial head (HP:0003083)2.13782780
62Multiple enchondromatosis (HP:0005701)2.13696859
63Recurrent fungal infections (HP:0002841)2.12782478
64Germ cell neoplasia (HP:0100728)2.11882583
65Slow saccadic eye movements (HP:0000514)2.10842736
66Cellulitis (HP:0100658)2.08530384
67Abnormality of the distal phalanx of the thumb (HP:0009617)2.07715869
68Abnormality of the ileum (HP:0001549)2.07208277
69Cystic hygroma (HP:0000476)2.02567560
70Muscle fiber inclusion bodies (HP:0100299)2.01274015
71Conjunctival telangiectasia (HP:0000524)2.00803106
72Mediastinal lymphadenopathy (HP:0100721)2.00750938
73Vertebral arch anomaly (HP:0008438)1.99519311
74Transitional cell carcinoma of the bladder (HP:0006740)1.97286615
75Abnormality of the radial head (HP:0003995)1.97240100
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96954511
77Nemaline bodies (HP:0003798)1.96231283
78Long eyelashes (HP:0000527)1.95962785
79Fused cervical vertebrae (HP:0002949)1.95491090
80Uterine leiomyosarcoma (HP:0002891)1.95365603
81Leiomyosarcoma (HP:0100243)1.95365603
82Inflammation of the large intestine (HP:0002037)1.94852344
83Myelodysplasia (HP:0002863)1.93487173
84Macroorchidism (HP:0000053)1.92389577
85Abnormality of chromosome stability (HP:0003220)1.92292136
86Small intestinal stenosis (HP:0012848)1.92166541
87Duodenal stenosis (HP:0100867)1.92166541
88Skin pits (HP:0100276)1.92088451
89Gingivitis (HP:0000230)1.92079585
90Deep philtrum (HP:0002002)1.91914204
91Muscle fiber splitting (HP:0003555)1.90464452
92Syringomyelia (HP:0003396)1.90382858
93Spinal cord lesions (HP:0100561)1.90382858
94Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89194365
95Large earlobe (HP:0009748)1.88593857
96Subacute progressive viral hepatitis (HP:0006572)1.88575873
97Abnormality of the nasal septum (HP:0000419)1.87563532
98Curly hair (HP:0002212)1.87521484
99Gastrointestinal inflammation (HP:0004386)1.87282080
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.87185817
101Bifid tongue (HP:0010297)1.86658178
102Obstructive sleep apnea (HP:0002870)1.86598008
103Generalized hypotonia (HP:0001290)1.86159158
104Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84664425
105Ectopic kidney (HP:0000086)1.83973129
106Hematochezia (HP:0002573)1.83493961
107Thyroid carcinoma (HP:0002890)1.83349516
108Meningitis (HP:0001287)1.83011935
109Congenital diaphragmatic hernia (HP:0000776)1.82587906
110Osteomyelitis (HP:0002754)1.81988230
111Supernumerary bones of the axial skeleton (HP:0009144)1.81912042
112Cubitus valgus (HP:0002967)1.81438554
113Overgrowth (HP:0001548)1.81434715
114Chest pain (HP:0100749)1.81262282
115Bladder neoplasm (HP:0009725)1.81240612
116Bladder carcinoma (HP:0002862)1.81240612
117Pendular nystagmus (HP:0012043)1.80746286
118Preauricular skin tag (HP:0000384)1.80739302
119Medulloblastoma (HP:0002885)1.80277170
120Abnormality of the columella (HP:0009929)1.80154370
121Acute lymphatic leukemia (HP:0006721)1.80137549
122Broad thumb (HP:0011304)1.79780464
123Embryonal neoplasm (HP:0002898)1.79580497
124Increased variability in muscle fiber diameter (HP:0003557)1.79453763
125Papilledema (HP:0001085)1.79372268
126Prolonged bleeding time (HP:0003010)1.78985863
127Sandal gap (HP:0001852)1.78671018
128Supernumerary ribs (HP:0005815)1.78514919
129Persistence of primary teeth (HP:0006335)1.77722771
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77686096
131Abnormality of the frontal sinuses (HP:0002687)1.77306047
132Skin tags (HP:0010609)1.75463297
133Glioma (HP:0009733)1.75134542
134Ankyloglossia (HP:0010296)1.73238713
135Short humerus (HP:0005792)1.73043348
136Abnormality of the pubic bones (HP:0003172)1.72896682
137Combined immunodeficiency (HP:0005387)1.72360333
138Increased connective tissue (HP:0009025)1.72183391
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72086540
140Lip pit (HP:0100267)1.71910314
141Abnormality of skeletal muscle fiber size (HP:0012084)1.71799591
142Ragged-red muscle fibers (HP:0003200)1.71692910
143Gastrointestinal infarctions (HP:0005244)1.71226673
144Autoimmune hemolytic anemia (HP:0001890)1.70564544
145Patellar aplasia (HP:0006443)1.69718166
146Aplasia/hypoplasia of the humerus (HP:0006507)1.68666789
147Aplasia/Hypoplasia of the macula (HP:0008059)1.68644262
148Facial diplegia (HP:0001349)1.68434030
149Hypoplasia of the thymus (HP:0000778)1.67439741
150Fatigue (HP:0012378)1.67354453
151Increased IgE level (HP:0003212)1.66327050
152Agammaglobulinemia (HP:0004432)1.66003845
153Testicular atrophy (HP:0000029)1.65586102
154Malignant gastrointestinal tract tumors (HP:0006749)1.64558733
155Gastrointestinal carcinoma (HP:0002672)1.64558733
156Vaginal fistula (HP:0004320)1.64224862
157Hypoplasia of the iris (HP:0007676)1.64120422
158Short 5th finger (HP:0009237)1.64005924
159Aplasia/Hypoplasia of the patella (HP:0006498)1.63705641
160Recurrent cutaneous fungal infections (HP:0011370)1.63110502
161Chronic mucocutaneous candidiasis (HP:0002728)1.63110502
162Prominent nose (HP:0000448)1.62986773
163Tapered finger (HP:0001182)1.62556717
164EMG: neuropathic changes (HP:0003445)1.62325865
165Pelvic girdle muscle weakness (HP:0003749)1.62260223
166Abnormality of incisor morphology (HP:0011063)1.61421011
167Atresia of the external auditory canal (HP:0000413)1.60335511
168Frequent falls (HP:0002359)1.59562089
169Webbed neck (HP:0000465)1.59553306
170Abnormality of the fovea (HP:0000493)1.59541269
171Abnormality of the incisor (HP:0000676)1.57679098
172Low anterior hairline (HP:0000294)1.57669590
173Blue irides (HP:0000635)1.56204606
174Thick eyebrow (HP:0000574)1.54172855
175Mitral valve prolapse (HP:0001634)1.54136522
176Generalized hypopigmentation of hair (HP:0011358)1.53401352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.72278499
2GRK52.68634133
3GRK62.59425488
4AKT32.53556067
5RIPK42.39504517
6TTK2.18214572
7PRPF4B2.04660739
8CSF1R2.00686542
9CAMK1G1.98401112
10MAP2K31.89505403
11SRPK11.87745579
12EEF2K1.86433974
13CDC71.85806154
14MAPK71.85557229
15SGK21.83049290
16LATS11.82073551
17MAP3K101.81864551
18MKNK21.78444367
19ERBB31.77483568
20STK101.77098906
21STK241.67272084
22ADRBK21.66955381
23CAMK1D1.66556069
24MAP3K131.64660414
25SGK31.62084274
26TGFBR21.61467524
27GRK11.58773207
28BRD41.57174556
29BLK1.51293094
30TRIB31.48112873
31CHUK1.39147402
32CAMK41.38097479
33NLK1.35108646
34MAP3K21.31352582
35MAP4K11.31131524
36CHEK21.29650629
37GRK71.29507003
38TTN1.29275247
39STK31.26818819
40MAP3K141.25624490
41ERN11.24787188
42MKNK11.23934567
43TYRO31.20886142
44KSR21.18122694
45NEK21.17844219
46FES1.17337649
47BMPR21.16683703
48WNK11.16499100
49HIPK21.16333800
50IKBKE1.15643503
51PIK3CG1.15585378
52STK41.15344995
53BTK1.12219201
54PLK11.10593979
55CDK71.07447323
56STK38L1.07362446
57ZAK1.06911923
58RET1.05877898
59MAP3K11.05700325
60PIM11.05067387
61KSR11.04467128
62SYK1.04059039
63TYK20.99256526
64HCK0.97370599
65TEC0.97327691
66ZAP700.97294419
67YES10.95224399
68MAP3K40.94568773
69MATK0.89148444
70IKBKB0.89063974
71CHEK10.89004178
72JAK20.87485381
73ALK0.85688643
74* FGFR30.83860657
75MELK0.81596233
76EIF2AK20.80970110
77IRAK40.80154394
78SCYL20.79227166
79TAOK30.78857796
80MARK30.78625240
81CAMKK10.78094674
82STK110.77135749
83TAF10.75656631
84CDK40.75590062
85MOS0.74287860
86ICK0.72956222
87IRAK10.72496077
88PDGFRB0.72447258
89CDK20.72113969
90DMPK0.71253665
91ATM0.71052361
92RIPK10.70371853
93MARK20.69544302
94CDK60.69044137
95OBSCN0.67383665
96MAP2K40.67296992
97LATS20.66123561
98PKN20.63865910
99RPS6KC10.62969649
100RPS6KL10.62969649
101FGFR40.62215823
102MAP3K70.61846120
103STK380.61453112
104SGK2230.60826345
105SGK4940.60826345
106CDK90.59983608
107PLK30.57371491
108AKT20.57006479
109AURKB0.56996923
110TXK0.56768839
111PDK10.55763481
112CLK10.55680618
113LCK0.55117621
114CSK0.54149201
115MAPK140.53954673
116RAF10.53137854
117ATR0.52542068
118TRPM70.52076725
119RPS6KB10.51750069
120LYN0.51501503
121FGR0.51348693
122PNCK0.51150767
123MAP3K50.50733746
124NEK60.50480427
125PDGFRA0.50071462
126CDK10.49373015
127KIT0.49357005
128RPS6KA60.49238492
129MAP3K30.49085254
130PRKAA10.48947387
131PLK40.48733837
132MTOR0.46460728
133AKT10.46272659
134SIK20.45464727
135PLK20.45373783
136MAPK120.44918496
137NEK10.44165572
138ADRBK10.43784402
139GSK3B0.40125131
140TAOK10.39570236
141MAPK100.39199488
142MAPK80.38382150
143JAK10.38290747
144JAK30.37800467
145PAK40.37322315
146BRSK20.36935754
147SGK10.36878965
148CDK30.36238254
149RPS6KA40.35555761
150RPS6KB20.33913219
151ITK0.33838088
152NEK90.33823928
153MAPK10.32856756
154PRKD20.32663492
155MAP3K60.31114906

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06971762
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92929821
3mRNA surveillance pathway_Homo sapiens_hsa030151.74407134
4Cell cycle_Homo sapiens_hsa041101.70542365
5Renal cell carcinoma_Homo sapiens_hsa052111.52176862
6mTOR signaling pathway_Homo sapiens_hsa041501.47506203
7MicroRNAs in cancer_Homo sapiens_hsa052061.45920982
8Fanconi anemia pathway_Homo sapiens_hsa034601.44719519
9Thyroid cancer_Homo sapiens_hsa052161.38626682
10Herpes simplex infection_Homo sapiens_hsa051681.34612742
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31503739
12Platelet activation_Homo sapiens_hsa046111.30951840
13Non-small cell lung cancer_Homo sapiens_hsa052231.27397314
14RNA transport_Homo sapiens_hsa030131.27294407
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26402720
16RNA degradation_Homo sapiens_hsa030181.25809780
17Endometrial cancer_Homo sapiens_hsa052131.24360179
18Colorectal cancer_Homo sapiens_hsa052101.23230777
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.22171895
20Primary immunodeficiency_Homo sapiens_hsa053401.20440586
21Adherens junction_Homo sapiens_hsa045201.19971007
22Acute myeloid leukemia_Homo sapiens_hsa052211.18673976
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18550400
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18144164
25B cell receptor signaling pathway_Homo sapiens_hsa046621.17113073
26Pancreatic cancer_Homo sapiens_hsa052121.16193908
27VEGF signaling pathway_Homo sapiens_hsa043701.15141647
28Type II diabetes mellitus_Homo sapiens_hsa049301.15072381
29Chronic myeloid leukemia_Homo sapiens_hsa052201.14179063
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13826993
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.12804056
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12640980
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06652094
34T cell receptor signaling pathway_Homo sapiens_hsa046601.06226660
35HTLV-I infection_Homo sapiens_hsa051661.05646972
36p53 signaling pathway_Homo sapiens_hsa041151.03690979
37Viral myocarditis_Homo sapiens_hsa054161.01931851
38Small cell lung cancer_Homo sapiens_hsa052221.01882168
39Hepatitis C_Homo sapiens_hsa051600.99781373
40Base excision repair_Homo sapiens_hsa034100.99618029
41Inositol phosphate metabolism_Homo sapiens_hsa005620.99465243
42FoxO signaling pathway_Homo sapiens_hsa040680.98654464
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98234653
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96124221
45Homologous recombination_Homo sapiens_hsa034400.95614251
46Long-term depression_Homo sapiens_hsa047300.94422956
47Hepatitis B_Homo sapiens_hsa051610.92455781
48Prolactin signaling pathway_Homo sapiens_hsa049170.92336521
49Notch signaling pathway_Homo sapiens_hsa043300.92038353
50Influenza A_Homo sapiens_hsa051640.91976415
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.90538233
52Mismatch repair_Homo sapiens_hsa034300.90489519
53Vitamin B6 metabolism_Homo sapiens_hsa007500.90453577
54Leishmaniasis_Homo sapiens_hsa051400.90425547
55Measles_Homo sapiens_hsa051620.89944983
56Insulin signaling pathway_Homo sapiens_hsa049100.89741778
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.89680807
58Prostate cancer_Homo sapiens_hsa052150.89417318
59Estrogen signaling pathway_Homo sapiens_hsa049150.89268879
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88343448
61Wnt signaling pathway_Homo sapiens_hsa043100.87737806
62Viral carcinogenesis_Homo sapiens_hsa052030.87187423
63TGF-beta signaling pathway_Homo sapiens_hsa043500.86885148
64Insulin resistance_Homo sapiens_hsa049310.85816882
65Pathways in cancer_Homo sapiens_hsa052000.85579620
66Dorso-ventral axis formation_Homo sapiens_hsa043200.85517775
67Apoptosis_Homo sapiens_hsa042100.85472059
68Glioma_Homo sapiens_hsa052140.85148010
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84986079
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84583065
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84087179
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.84034874
73Hippo signaling pathway_Homo sapiens_hsa043900.83274552
74Dilated cardiomyopathy_Homo sapiens_hsa054140.83001728
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82987228
76Proteoglycans in cancer_Homo sapiens_hsa052050.81884947
77Toxoplasmosis_Homo sapiens_hsa051450.81866917
78Oxytocin signaling pathway_Homo sapiens_hsa049210.81862671
79Spliceosome_Homo sapiens_hsa030400.80744940
80Cholinergic synapse_Homo sapiens_hsa047250.79876168
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79720870
82Circadian rhythm_Homo sapiens_hsa047100.79590492
83DNA replication_Homo sapiens_hsa030300.79298912
84Olfactory transduction_Homo sapiens_hsa047400.79256545
85Non-homologous end-joining_Homo sapiens_hsa034500.78929917
86MAPK signaling pathway_Homo sapiens_hsa040100.78827156
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78123279
88Amoebiasis_Homo sapiens_hsa051460.77942713
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77270372
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.77252835
91Long-term potentiation_Homo sapiens_hsa047200.76565386
92Basal cell carcinoma_Homo sapiens_hsa052170.76265343
93Oocyte meiosis_Homo sapiens_hsa041140.75410819
94Basal transcription factors_Homo sapiens_hsa030220.75396037
95Choline metabolism in cancer_Homo sapiens_hsa052310.75046311
96Graft-versus-host disease_Homo sapiens_hsa053320.73812822
97Osteoclast differentiation_Homo sapiens_hsa043800.73780052
98ErbB signaling pathway_Homo sapiens_hsa040120.73496741
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72748505
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72725192
101Chemokine signaling pathway_Homo sapiens_hsa040620.72571852
102Allograft rejection_Homo sapiens_hsa053300.71500893
103Galactose metabolism_Homo sapiens_hsa000520.70265498
104Renin secretion_Homo sapiens_hsa049240.69498601
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69432485
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68455266
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.68216158
108Autoimmune thyroid disease_Homo sapiens_hsa053200.66997750
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65400064
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65358135
111TNF signaling pathway_Homo sapiens_hsa046680.65021564
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64983505
113Systemic lupus erythematosus_Homo sapiens_hsa053220.64606141
114GnRH signaling pathway_Homo sapiens_hsa049120.63791597
115Malaria_Homo sapiens_hsa051440.62960193
116Tuberculosis_Homo sapiens_hsa051520.62914610
117AMPK signaling pathway_Homo sapiens_hsa041520.62820406
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62692547
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62630053
120Rap1 signaling pathway_Homo sapiens_hsa040150.61743158
121Staphylococcus aureus infection_Homo sapiens_hsa051500.61627489
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.61620527
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.61506416
124Hematopoietic cell lineage_Homo sapiens_hsa046400.61271848
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60884327
126Ras signaling pathway_Homo sapiens_hsa040140.60229647
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.60091179
128Gap junction_Homo sapiens_hsa045400.59494619
129Epstein-Barr virus infection_Homo sapiens_hsa051690.58519823
130Focal adhesion_Homo sapiens_hsa045100.57463581
131HIF-1 signaling pathway_Homo sapiens_hsa040660.54894581
132Alcoholism_Homo sapiens_hsa050340.54164544

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