DYRK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of chemical stimulus (GO:0007606)9.77574297
2G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)9.55868666
3regulation of cilium movement (GO:0003352)9.31508421
4axonemal dynein complex assembly (GO:0070286)7.52601641
5protein localization to cilium (GO:0061512)6.83013732
6protein polyglutamylation (GO:0018095)6.50515518
7cilium or flagellum-dependent cell motility (GO:0001539)6.41908160
8epithelial cilium movement (GO:0003351)6.35189224
9oligosaccharide catabolic process (GO:0009313)6.20742817
10purinergic nucleotide receptor signaling pathway (GO:0035590)6.19685132
11cilium movement (GO:0003341)6.18896817
12protein insertion into membrane (GO:0051205)6.02391677
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.95892946
14acrosome reaction (GO:0007340)5.84970588
15microglial cell activation (GO:0001774)5.77681263
16intraciliary transport (GO:0042073)5.75617272
17G-protein coupled purinergic receptor signaling pathway (GO:0035588)5.71472140
18regulation of chromatin binding (GO:0035561)5.69475913
19regulation of female gonad development (GO:2000194)5.66524666
20proteasome assembly (GO:0043248)5.65193260
21sperm motility (GO:0030317)5.58961877
22fusion of sperm to egg plasma membrane (GO:0007342)5.47871424
23multicellular organism reproduction (GO:0032504)5.15790903
24response to pheromone (GO:0019236)5.15676236
25sperm-egg recognition (GO:0035036)5.14707455
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.13134529
27regulation of microtubule-based movement (GO:0060632)5.07712371
28phosphatidylglycerol biosynthetic process (GO:0006655)4.97318828
29negative regulation of norepinephrine secretion (GO:0010700)4.97205510
30microtubule severing (GO:0051013)4.96923514
31axoneme assembly (GO:0035082)4.91874347
32cell-cell recognition (GO:0009988)4.89185602
33single fertilization (GO:0007338)4.84152713
34adenosine receptor signaling pathway (GO:0001973)4.78320894
35acrosome assembly (GO:0001675)4.77208898
36motile cilium assembly (GO:0044458)4.76792242
37ATP synthesis coupled proton transport (GO:0015986)4.74044141
38energy coupled proton transport, down electrochemical gradient (GO:0015985)4.74044141
39rRNA modification (GO:0000154)4.71457735
40binding of sperm to zona pellucida (GO:0007339)4.67082895
41adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.65513168
42rRNA methylation (GO:0031167)4.53676571
43cilium morphogenesis (GO:0060271)4.53613731
44purinergic receptor signaling pathway (GO:0035587)4.49283009
45spermatid nucleus differentiation (GO:0007289)4.43865172
46protein complex biogenesis (GO:0070271)4.43532893
47auditory receptor cell differentiation (GO:0042491)4.40532637
48reproduction (GO:0000003)4.31727372
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.26793922
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.26793922
51olfactory bulb development (GO:0021772)4.26635511
52spermatid development (GO:0007286)4.19349345
53mitochondrial respiratory chain complex assembly (GO:0033108)4.09409546
54plasma membrane fusion (GO:0045026)4.08527806
55establishment of protein localization to mitochondrial membrane (GO:0090151)4.04294881
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02819874
57cell wall macromolecule metabolic process (GO:0044036)3.98045133
58cell wall macromolecule catabolic process (GO:0016998)3.98045133
59natural killer cell mediated immunity (GO:0002228)3.96423258
60natural killer cell mediated cytotoxicity (GO:0042267)3.96423258
61fertilization (GO:0009566)3.88699729
62NADH dehydrogenase complex assembly (GO:0010257)3.86666648
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86666648
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.86666648
65phenylpropanoid metabolic process (GO:0009698)3.79017856
66phosphorelay signal transduction system (GO:0000160)3.75296287
67microtubule depolymerization (GO:0007019)3.75259018
68cyclooxygenase pathway (GO:0019371)3.72586199
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71720184
70amyloid precursor protein catabolic process (GO:0042987)3.63752574
71respiratory electron transport chain (GO:0022904)3.63548014
72glycosphingolipid catabolic process (GO:0046479)3.59075070
73electron transport chain (GO:0022900)3.58064198
74ribosomal small subunit assembly (GO:0000028)3.56011463
75negative regulation of inclusion body assembly (GO:0090084)3.52628651
76single strand break repair (GO:0000012)3.52509662
77detection of calcium ion (GO:0005513)3.48300471
78chaperone-mediated protein transport (GO:0072321)3.45933874
79regulation of mitochondrial translation (GO:0070129)3.45751046
80platelet dense granule organization (GO:0060155)3.38623582
81peptidyl-histidine modification (GO:0018202)3.37146856
82piRNA metabolic process (GO:0034587)3.36532270
83macrophage activation involved in immune response (GO:0002281)3.35274456
84male meiosis I (GO:0007141)3.34361746
85GTP biosynthetic process (GO:0006183)3.32256950
86negative regulation of catecholamine secretion (GO:0033604)3.32135036
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31154972
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30659092
89negative regulation of cell killing (GO:0031342)3.30659092
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27884556
91cotranslational protein targeting to membrane (GO:0006613)3.24538000
92male meiosis (GO:0007140)3.22071198
93sequestering of actin monomers (GO:0042989)3.19802469
94cellular ketone body metabolic process (GO:0046950)3.19255183
95protein targeting to ER (GO:0045047)3.18892015
96respiratory chain complex IV assembly (GO:0008535)3.17553532
97glycolipid catabolic process (GO:0019377)3.16086470
98cytochrome complex assembly (GO:0017004)3.15733546
99cAMP biosynthetic process (GO:0006171)3.15276476
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14966555
101DNA integration (GO:0015074)3.13999638
102chemical homeostasis within a tissue (GO:0048875)3.13261377
103DNA packaging (GO:0006323)3.11913292
104regulation of chronic inflammatory response (GO:0002676)3.11107986
105centriole assembly (GO:0098534)3.10955831
106spermatogenesis (GO:0007283)3.09552084
107male gamete generation (GO:0048232)3.07935763
108establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07413072
109regulation of cellular amino acid metabolic process (GO:0006521)3.07372166
110protein localization to endoplasmic reticulum (GO:0070972)3.06479282
111protein neddylation (GO:0045116)3.05859565
112calcium ion-dependent exocytosis (GO:0017156)3.05581776
113cilium assembly (GO:0042384)3.04004209
114chromosome condensation (GO:0030261)3.03248589
115mannosylation (GO:0097502)3.03130459
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02611750
117resolution of meiotic recombination intermediates (GO:0000712)3.02199888
118purine-containing compound salvage (GO:0043101)3.01803415
119GMP metabolic process (GO:0046037)3.01075170
120ketone body metabolic process (GO:1902224)3.00860758
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00753994
122cilium organization (GO:0044782)2.99898633
123purine nucleotide salvage (GO:0032261)2.98410269
124sperm capacitation (GO:0048240)2.97551631
125cellular response to fluid shear stress (GO:0071498)2.97184712
126gamete generation (GO:0007276)2.96976306
127microtubule bundle formation (GO:0001578)2.96872124
128mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.96515478
129peptidyl-threonine dephosphorylation (GO:0035970)2.95617715
130UTP biosynthetic process (GO:0006228)2.94470078
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94137076
132viral transcription (GO:0019083)2.93821430
133peptidyl-glutamic acid modification (GO:0018200)2.93478309
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92257167
135negative regulation of ligase activity (GO:0051352)2.91840053
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91840053
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91112323
138membrane protein intracellular domain proteolysis (GO:0031293)2.90427092
139translational termination (GO:0006415)2.90122714
140brain morphogenesis (GO:0048854)2.89336691
141response to laminar fluid shear stress (GO:0034616)2.88186415
142glycerol ether metabolic process (GO:0006662)2.87029091
143purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86632820
144hydrogen ion transmembrane transport (GO:1902600)2.86522997
145microtubule polymerization or depolymerization (GO:0031109)2.84837325
146regulation of B cell receptor signaling pathway (GO:0050855)2.84120531
147inner mitochondrial membrane organization (GO:0007007)2.83881875
148signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83824676
149signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83824676
150signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83824676
151nucleoside diphosphate phosphorylation (GO:0006165)2.83503477
152signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82425119
153intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82425119
154anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79909252
155positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79814022
156protein targeting to mitochondrion (GO:0006626)2.79192185
157leukocyte mediated cytotoxicity (GO:0001909)2.77844128
158synaptonemal complex organization (GO:0070193)2.77783204
159ceramide catabolic process (GO:0046514)2.77469141
160tolerance induction (GO:0002507)2.77177748
161purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75413248
162adipose tissue development (GO:0060612)2.75400210
163dopamine receptor signaling pathway (GO:0007212)2.75051717
164seminiferous tubule development (GO:0072520)2.74948717
165ribosomal large subunit biogenesis (GO:0042273)2.74284330
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72716703
167behavioral response to pain (GO:0048266)2.70835321
168activation of protein kinase A activity (GO:0034199)2.68492806
169centriole replication (GO:0007099)2.67227362
170regulation of inclusion body assembly (GO:0090083)2.65957211
171cellular process involved in reproduction in multicellular organism (GO:0022412)2.65208297
172cellular potassium ion transport (GO:0071804)2.61064049
173potassium ion transmembrane transport (GO:0071805)2.61064049
174sensory perception of smell (GO:0007608)16.2797300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.36752982
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.86649495
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.80494995
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59320531
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.35306275
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.69012029
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61277314
8ZNF263_19887448_ChIP-Seq_K562_Human3.49245565
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44170601
10TAF15_26573619_Chip-Seq_HEK293_Human3.34293622
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29677425
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99784680
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90102462
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.84897278
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81729862
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80193371
17ELK1_19687146_ChIP-ChIP_HELA_Human2.59577735
18VDR_23849224_ChIP-Seq_CD4+_Human2.41897321
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38555541
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.38555541
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32399676
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.31452819
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29562026
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27078619
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26645841
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18491298
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10438836
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07406428
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.04464346
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03717785
31FOXP3_21729870_ChIP-Seq_TREG_Human1.98138926
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.97698136
33ZNF274_21170338_ChIP-Seq_K562_Hela1.87885045
34AHR_22903824_ChIP-Seq_MCF-7_Human1.84537172
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83239462
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.80008907
37VDR_22108803_ChIP-Seq_LS180_Human1.76483263
38DROSHA_22980978_ChIP-Seq_HELA_Human1.72301800
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.71737510
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.69738289
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67669292
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.64583832
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.61780366
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.59689949
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59518878
46GABP_19822575_ChIP-Seq_HepG2_Human1.59370366
47DCP1A_22483619_ChIP-Seq_HELA_Human1.57001951
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56815159
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53947963
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53741049
51FUS_26573619_Chip-Seq_HEK293_Human1.53156139
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.52499931
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.51268919
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49395728
55GF1_26923725_Chip-Seq_HPCs_Mouse1.48676527
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47928022
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43875871
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42749942
59STAT1_17558387_ChIP-Seq_HELA_Human1.42416064
60GBX2_23144817_ChIP-Seq_PC3_Human1.39838964
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39427638
62RNF2_27304074_Chip-Seq_NSC_Mouse1.37876343
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37778346
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.36885858
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36397586
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36218198
67ERG_20517297_ChIP-Seq_VCAP_Human1.35909245
68GATA3_27048872_Chip-Seq_THYMUS_Human1.35666180
69SCL_19346495_ChIP-Seq_HPC-7_Human1.35186442
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34689695
71IGF1R_20145208_ChIP-Seq_DFB_Human1.34650944
72MYC_18940864_ChIP-ChIP_HL60_Human1.34045610
73RUNX_20019798_ChIP-Seq_JUKART_Human1.34008882
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33808961
75TTF2_22483619_ChIP-Seq_HELA_Human1.33073993
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32002273
77MYC_19829295_ChIP-Seq_ESCs_Human1.31687686
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30603251
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29786881
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28630408
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25934248
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.25467567
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.23594566
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.23024794
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22996588
86FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22722535
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22548688
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21492501
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21060271
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.20972632
91* SOX2_19829295_ChIP-Seq_ESCs_Human1.20467439
92* NANOG_19829295_ChIP-Seq_ESCs_Human1.20467439
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20287178
94* TCF4_22108803_ChIP-Seq_LS180_Human1.19492163
95EWS_26573619_Chip-Seq_HEK293_Human1.19044592
96ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17902195
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16780971
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16736463
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16621168
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16212357
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15987702
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14650060
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13056784
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12038771
105ETV1_20927104_ChIP-Seq_GIST48_Human1.11110486
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11016437
107* NANOG_20526341_ChIP-Seq_ESCs_Human1.10080390
108AR_20517297_ChIP-Seq_VCAP_Human1.09646070
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.09572990
110* GATA3_21867929_ChIP-Seq_TH1_Mouse1.08867336
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.08699651
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08552220
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.08411194
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08411194
115* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07261972
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07116264
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06450801
118PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05705676
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05354648
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05150445
121SMAD4_21799915_ChIP-Seq_A2780_Human1.05061162
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04754361
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04136666
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.03799214
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03508267
126SMRT_27268052_Chip-Seq_Bcells_Human1.03394648
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02559780
128* ERA_21632823_ChIP-Seq_H3396_Human1.02107525
129* FOXH1_21741376_ChIP-Seq_EPCs_Human1.01381662
130MYB_26560356_Chip-Seq_TH2_Human1.00920570
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00856457
132* CDX2_22108803_ChIP-Seq_LS180_Human1.00789314
133* GATA3_21867929_ChIP-Seq_CD8_Mouse1.00634659
134SALL4_22934838_ChIP-ChIP_CD34+_Human1.00320194
135STAT1_20625510_ChIP-Seq_HELA_Human0.99842467
136ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99683389
137* TAF2_19829295_ChIP-Seq_ESCs_Human0.99239382
138TP53_22573176_ChIP-Seq_HFKS_Human0.98901776
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.98770769
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98535775
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97866887
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97765594
143XRN2_22483619_ChIP-Seq_HELA_Human0.97621172
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97334695
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96437039
146CBP_20019798_ChIP-Seq_JUKART_Human0.96437039
147FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95511217
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95053943
149PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95019196
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93878224
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93691561
152IRF1_19129219_ChIP-ChIP_H3396_Human0.93616704
153POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92469090
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92222509
155CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92068240
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91771960
157P53_22387025_ChIP-Seq_ESCs_Mouse0.91136480
158STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90983982
159CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90835167
160LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89737094
161REST_21632747_ChIP-Seq_MESCs_Mouse0.89557220
162* P300_19829295_ChIP-Seq_ESCs_Human0.89217668
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89096588
164TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88987035
165LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88710530
166WDR5_24793694_ChIP-Seq_LNCAP_Human0.88397796
167GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88248991
168KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88246454
169TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87990746
170TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87372525
171VDR_24787735_ChIP-Seq_THP-1_Human0.83630215
172STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82448150
173ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80982628
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.80865523
175EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80758638
176FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80196202
177KDM2B_26808549_Chip-Seq_REH_Human0.79770444
178SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78693433
179NFE2_27457419_Chip-Seq_LIVER_Mouse0.78584377
180SPI1_23127762_ChIP-Seq_K562_Human0.78153874
181ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78045943
182AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77871533
183TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77367293
184SOX11_22085726_ChIP-Seq_ESNs_Mouse0.75623988
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75547527
186VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74950100
187SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74610852
188IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74024404
189GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73987864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.08017281
2MP0006082_CNS_inflammation3.62967409
3MP0008789_abnormal_olfactory_epithelium3.47061804
4MP0005499_abnormal_olfactory_system3.01495825
5MP0005394_taste/olfaction_phenotype3.01495825
6MP0002837_dystrophic_cardiac_calcinosis2.97481097
7MP0003195_calcinosis2.91687929
8MP0000372_irregular_coat_pigmentation2.87112884
9MP0006054_spinal_hemorrhage2.63281210
10MP0009333_abnormal_splenocyte_physiolog2.63046476
11MP0006072_abnormal_retinal_apoptosis2.57473655
12MP0005408_hypopigmentation2.54442077
13MP0003191_abnormal_cellular_cholesterol2.51272614
14MP0005645_abnormal_hypothalamus_physiol2.38353707
15MP0003011_delayed_dark_adaptation2.20318801
16MP0006036_abnormal_mitochondrial_physio2.15448655
17MP0002234_abnormal_pharynx_morphology2.11117835
18MP0005084_abnormal_gallbladder_morpholo2.07338893
19MP0005253_abnormal_eye_physiology2.06348123
20MP0001984_abnormal_olfaction13.4510088
21MP0003718_maternal_effect1.94202633
22MP0003693_abnormal_embryo_hatching1.93531023
23MP0003698_abnormal_male_reproductive1.92899285
24MP0002160_abnormal_reproductive_system1.92223955
25MP0003186_abnormal_redox_activity1.91060459
26MP0009697_abnormal_copulation1.82909922
27MP0005058_abnormal_lysosome_morphology1.76295230
28MP0002184_abnormal_innervation1.68977911
29MP0002938_white_spotting1.68342311
30MP0005377_hearing/vestibular/ear_phenot1.67942864
31MP0003878_abnormal_ear_physiology1.67942864
32MP0006292_abnormal_olfactory_placode1.65179086
33MP0001929_abnormal_gametogenesis1.61707833
34MP0002282_abnormal_trachea_morphology1.57366097
35MP0001764_abnormal_homeostasis1.56488182
36MP0008877_abnormal_DNA_methylation1.56036180
37MP0003252_abnormal_bile_duct1.54021600
38MP0005551_abnormal_eye_electrophysiolog1.52635392
39MP0001485_abnormal_pinna_reflex1.52217526
40MP0002095_abnormal_skin_pigmentation1.45576541
41MP0003786_premature_aging1.44647923
42MP0002102_abnormal_ear_morphology1.34030532
43MP0002210_abnormal_sex_determination1.33317891
44MP0004147_increased_porphyrin_level1.32863860
45MP0001542_abnormal_bone_strength1.30408116
46MP0004742_abnormal_vestibular_system1.29367434
47MP0006035_abnormal_mitochondrial_morpho1.27659254
48MP0003950_abnormal_plasma_membrane1.22107392
49MP0005379_endocrine/exocrine_gland_phen1.21738256
50MP0001835_abnormal_antigen_presentation1.19743085
51MP0010386_abnormal_urinary_bladder1.19574323
52MP0005623_abnormal_meninges_morphology1.19178198
53MP0005174_abnormal_tail_pigmentation1.16963061
54MP0002090_abnormal_vision1.16142517
55MP0009379_abnormal_foot_pigmentation1.13212871
56MP0005075_abnormal_melanosome_morpholog1.11184122
57MP0009764_decreased_sensitivity_to1.11174894
58MP0002138_abnormal_hepatobiliary_system1.10031592
59MP0001145_abnormal_male_reproductive1.09581447
60MP0005671_abnormal_response_to1.09561710
61MP0002653_abnormal_ependyma_morphology1.08841778
62MP0003077_abnormal_cell_cycle1.08243760
63MP0005464_abnormal_platelet_physiology1.04478760
64MP0002161_abnormal_fertility/fecundity1.04300909
65MP0002009_preneoplasia1.04136638
66MP0000358_abnormal_cell_content/1.03574652
67MP0004142_abnormal_muscle_tone1.03298617
68MP0005389_reproductive_system_phenotype1.00899962
69MP0002928_abnormal_bile_duct1.00353493
70MP0000026_abnormal_inner_ear1.00214510
71MP0000516_abnormal_urinary_system0.99421697
72MP0005367_renal/urinary_system_phenotyp0.99421697
73MP0003763_abnormal_thymus_physiology0.99238321
74MP0000015_abnormal_ear_pigmentation0.99101618
75MP0002295_abnormal_pulmonary_circulatio0.98409107
76MP0002557_abnormal_social/conspecific_i0.97933788
77MP0001529_abnormal_vocalization0.97801985
78MP0005670_abnormal_white_adipose0.96729538
79MP0001986_abnormal_taste_sensitivity0.96401348
80MP0005391_vision/eye_phenotype0.95464231
81MP0001879_abnormal_lymphatic_vessel0.95176338
82MP0001905_abnormal_dopamine_level0.93901187
83MP0000653_abnormal_sex_gland0.93752108
84MP0003303_peritoneal_inflammation0.93330898
85MP0000343_altered_response_to0.92072833
86MP0009785_altered_susceptibility_to0.91402056
87MP0001800_abnormal_humoral_immune0.91138853
88MP0002148_abnormal_hypersensitivity_rea0.90814445
89MP0005165_increased_susceptibility_to0.87528562
90MP0001324_abnormal_eye_pigmentation0.87463436
91MP0002405_respiratory_system_inflammati0.87449089
92MP0005636_abnormal_mineral_homeostasis0.85731841
93MP0010094_abnormal_chromosome_stability0.85294537
94MP0003646_muscle_fatigue0.85275371
95MP0005395_other_phenotype0.83563518
96MP0001851_eye_inflammation0.82712364
97MP0002752_abnormal_somatic_nervous0.82489355
98MP0010030_abnormal_orbit_morphology0.80893410
99MP0002452_abnormal_antigen_presenting0.80448618
100MP0003941_abnormal_skin_development0.80248365
101MP0008995_early_reproductive_senescence0.79656835
102MP0001915_intracranial_hemorrhage0.79375823
103MP0002233_abnormal_nose_morphology0.78167070
104MP0005000_abnormal_immune_tolerance0.77453214
105MP0002163_abnormal_gland_morphology0.76718799
106MP0001293_anophthalmia0.76505947
107MP0001486_abnormal_startle_reflex0.76380058
108MP0000749_muscle_degeneration0.76282775
109MP0002822_catalepsy0.76031007
110MP0003806_abnormal_nucleotide_metabolis0.75699943
111MP0002734_abnormal_mechanical_nocicepti0.75308177
112MP0002139_abnormal_hepatobiliary_system0.75193785
113MP0004885_abnormal_endolymph0.74477854
114MP0005248_abnormal_Harderian_gland0.74077317
115MP0004215_abnormal_myocardial_fiber0.74056160
116MP0003690_abnormal_glial_cell0.73818248
117MP0002132_abnormal_respiratory_system0.73626945
118MP0008874_decreased_physiological_sensi0.72285293
119MP0008058_abnormal_DNA_repair0.72120309
120MP0005195_abnormal_posterior_eye0.71608013
121MP0003943_abnormal_hepatobiliary_system0.71325984
122MP0010368_abnormal_lymphatic_system0.69221634
123MP0003137_abnormal_impulse_conducting0.67179461
124MP0001853_heart_inflammation0.67111242
125MP0001873_stomach_inflammation0.67108204
126MP0005266_abnormal_metabolism0.65624960
127MP0002877_abnormal_melanocyte_morpholog0.65558288
128MP0005310_abnormal_salivary_gland0.64887139
129MP0008004_abnormal_stomach_pH0.64727814
130MP0008007_abnormal_cellular_replicative0.64339202
131MP0002723_abnormal_immune_serum0.64282601
132MP0004957_abnormal_blastocyst_morpholog0.63319313
133MP0001819_abnormal_immune_cell0.62516882
134MP0002420_abnormal_adaptive_immunity0.62207085
135MP0001963_abnormal_hearing_physiology0.61982391
136MP0002882_abnormal_neuron_morphology0.57896924
137MP0004270_analgesia0.53905298
138MP0000534_abnormal_ureter_morphology0.53202754
139MP0001270_distended_abdomen0.53170811
140MP0005166_decreased_susceptibility_to0.51732519
141MP0004858_abnormal_nervous_system0.51274216
142MP0003136_yellow_coat_color0.51106251
143MP0004811_abnormal_neuron_physiology0.50979047
144MP0000003_abnormal_adipose_tissue0.50121129
145MP0004510_myositis0.50004196
146MP0002152_abnormal_brain_morphology0.49725625
147MP0004883_abnormal_blood_vessel0.46550568
148MP0000716_abnormal_immune_system0.45588992
149MP0003075_altered_response_to0.45107337
150MP0003634_abnormal_glial_cell0.44964334
151MP0001970_abnormal_pain_threshold0.44921440
152MP0001845_abnormal_inflammatory_respons0.43775140
153MP0002272_abnormal_nervous_system0.42729088
154MP0009053_abnormal_anal_canal0.42179637
155MP0001968_abnormal_touch/_nociception0.41870077
156MP0005167_abnormal_blood-brain_barrier0.41389848
157MP0003879_abnormal_hair_cell0.41287620
158MP0002398_abnormal_bone_marrow0.41197632
159MP0002229_neurodegeneration0.41092153
160MP0002396_abnormal_hematopoietic_system0.40987414
161MP0002736_abnormal_nociception_after0.40884837

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.91638389
2Abnormal respiratory epithelium morphology (HP:0012253)7.08695425
3Abnormal respiratory motile cilium morphology (HP:0005938)7.08695425
4Abnormal respiratory motile cilium physiology (HP:0012261)7.01674484
5Absent/shortened dynein arms (HP:0200106)6.30800306
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.30800306
7Rhinitis (HP:0012384)6.13040589
8Abnormal ciliary motility (HP:0012262)6.11523076
9Retinal dysplasia (HP:0007973)5.37539557
10Bifid tongue (HP:0010297)5.14279559
11Acute necrotizing encephalopathy (HP:0006965)4.82159752
12Molar tooth sign on MRI (HP:0002419)4.54523493
13Abnormality of midbrain morphology (HP:0002418)4.54523493
14Abnormal mitochondria in muscle tissue (HP:0008316)4.46433501
15Bronchiectasis (HP:0002110)4.39823439
16Mitochondrial inheritance (HP:0001427)4.37880009
17Chronic bronchitis (HP:0004469)4.24673100
18Acute encephalopathy (HP:0006846)4.22845462
19Progressive macrocephaly (HP:0004481)4.00854462
20Urethral obstruction (HP:0000796)3.91086144
21Nasal polyposis (HP:0100582)3.86242294
22Increased CSF lactate (HP:0002490)3.80173866
233-Methylglutaconic aciduria (HP:0003535)3.80039441
24Recurrent sinusitis (HP:0011108)3.74264226
25Abolished electroretinogram (ERG) (HP:0000550)3.73720723
26Renal Fanconi syndrome (HP:0001994)3.60863807
27Hepatocellular necrosis (HP:0001404)3.52682098
28Medial flaring of the eyebrow (HP:0010747)3.49787093
29Severe visual impairment (HP:0001141)3.47347400
30Split foot (HP:0001839)3.44772199
31Type I transferrin isoform profile (HP:0003642)3.44059768
32Hepatic necrosis (HP:0002605)3.37580968
33Recurrent otitis media (HP:0000403)3.36241061
34Intestinal atresia (HP:0011100)3.31083331
35Congenital primary aphakia (HP:0007707)3.23178239
36Gait imbalance (HP:0002141)3.22795545
37Increased hepatocellular lipid droplets (HP:0006565)3.22616351
38Generalized aminoaciduria (HP:0002909)3.22065463
39Abnormality of liposaccharide metabolism (HP:0010968)3.20418282
40Abnormality of glycosphingolipid metabolism (HP:0004343)3.20418282
41Abnormality of glycolipid metabolism (HP:0010969)3.20418282
42Cerebral edema (HP:0002181)3.19077543
43Lipid accumulation in hepatocytes (HP:0006561)3.16876559
44Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14180998
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14180998
46Amyloidosis (HP:0011034)3.11625077
47Bronchitis (HP:0012387)3.10788782
48Chronic sinusitis (HP:0011109)3.08186137
49Renal hypoplasia (HP:0000089)3.08155067
50Nephrogenic diabetes insipidus (HP:0009806)2.99364156
51Bony spicule pigmentary retinopathy (HP:0007737)2.97588046
52Abnormality of the nasal mucosa (HP:0000433)2.95764103
53Infertility (HP:0000789)2.95265757
54Limb dystonia (HP:0002451)2.91972983
55Abnormality of macular pigmentation (HP:0008002)2.88397669
56Absent eyebrow (HP:0002223)2.88394588
57Pancreatic cysts (HP:0001737)2.85081181
58Optic disc pallor (HP:0000543)2.83549944
59Constricted visual fields (HP:0001133)2.83083006
60Vacuolated lymphocytes (HP:0001922)2.80773139
61Methylmalonic acidemia (HP:0002912)2.75962257
62Attenuation of retinal blood vessels (HP:0007843)2.75157057
63Abnormal protein glycosylation (HP:0012346)2.73451634
64Abnormal glycosylation (HP:0012345)2.73451634
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73451634
66Abnormal protein N-linked glycosylation (HP:0012347)2.73451634
67Vaginal atresia (HP:0000148)2.72127833
68Xerostomia (HP:0000217)2.69467489
69Dysphonia (HP:0001618)2.69041292
70Atonic seizures (HP:0010819)2.62789497
71Nephronophthisis (HP:0000090)2.61598032
72Increased intramyocellular lipid droplets (HP:0012240)2.61086877
73Postaxial hand polydactyly (HP:0001162)2.60681748
74Reduced antithrombin III activity (HP:0001976)2.57166270
75Exertional dyspnea (HP:0002875)2.56373034
76Genital tract atresia (HP:0001827)2.56021245
77Lactic acidosis (HP:0003128)2.55153042
78Methylmalonic aciduria (HP:0012120)2.53885806
79Abnormality of cochlea (HP:0000375)2.49365380
80Abnormal rod and cone electroretinograms (HP:0008323)2.45113604
81Respiratory failure (HP:0002878)2.44960485
82Abnormality of renal resorption (HP:0011038)2.40550453
83Bile duct proliferation (HP:0001408)2.38605601
84Abnormal biliary tract physiology (HP:0012439)2.38605601
85Testicular atrophy (HP:0000029)2.37445455
86Glycosuria (HP:0003076)2.36405333
87Abnormality of urine glucose concentration (HP:0011016)2.36405333
88Poor coordination (HP:0002370)2.36250115
89Recurrent bronchitis (HP:0002837)2.34865904
90True hermaphroditism (HP:0010459)2.33050055
91Impaired platelet aggregation (HP:0003540)2.31544892
92Abnormal platelet function (HP:0011869)2.31544892
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.30947180
94Hypothermia (HP:0002045)2.28052433
95Abnormality of the renal medulla (HP:0100957)2.27792992
96Abnormality of placental membranes (HP:0011409)2.27407944
97Amniotic constriction ring (HP:0009775)2.27407944
98Sclerocornea (HP:0000647)2.27232347
99Increased serum lactate (HP:0002151)2.27152515
100Partial duplication of thumb phalanx (HP:0009944)2.26238121
101Febrile seizures (HP:0002373)2.25600593
102Facial cleft (HP:0002006)2.23988288
103Cystic liver disease (HP:0006706)2.23719942
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22884723
105Palpitations (HP:0001962)2.22603306
106Hyperglycinemia (HP:0002154)2.22104807
107Anosmia (HP:0000458)2.21366880
108Chronic hepatic failure (HP:0100626)2.19499887
109Aplasia/Hypoplasia of the lens (HP:0008063)2.17235405
110Increased muscle lipid content (HP:0009058)2.14629597
111Tubulointerstitial nephritis (HP:0001970)2.12394005
112Supernumerary spleens (HP:0009799)2.10526628
113Preauricular pit (HP:0004467)2.10437301
114Periauricular skin pits (HP:0100277)2.10437301
115Reticulocytopenia (HP:0001896)2.10276841
116Dicarboxylic aciduria (HP:0003215)2.09092379
117Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09092379
118Pancreatic fibrosis (HP:0100732)2.08557508
119Median cleft lip (HP:0000161)2.07213010
120Lethargy (HP:0001254)2.06401637
121Exercise intolerance (HP:0003546)2.05361948
122Renal dysplasia (HP:0000110)2.02538222
123Opisthotonus (HP:0002179)2.02210059
124Abnormality of DNA repair (HP:0003254)2.01776561
125Type 2 muscle fiber atrophy (HP:0003554)2.01381533
126Oculomotor apraxia (HP:0000657)1.98102846
127Dysostosis multiplex (HP:0000943)1.97835429
128Microvesicular hepatic steatosis (HP:0001414)1.97048127
129Abnormality of the anterior horn cell (HP:0006802)1.96440202
130Degeneration of anterior horn cells (HP:0002398)1.96440202
131Macrocytic anemia (HP:0001972)1.92508599
132Occipital encephalocele (HP:0002085)1.91275907
133Anencephaly (HP:0002323)1.89789342
134Male pseudohermaphroditism (HP:0000037)1.89442917
135Short nail (HP:0001799)1.88288345
136Glomerulonephritis (HP:0000099)1.87663748
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87589777
138Abnormality of the dental root (HP:0006486)1.87564464
139Taurodontia (HP:0000679)1.87564464
140Abnormality of permanent molar morphology (HP:0011071)1.87564464
141Nausea (HP:0002018)1.87012280
142Dyschromatopsia (HP:0007641)1.86625580
143Leukodystrophy (HP:0002415)1.86587348
144Syncope (HP:0001279)1.86281450
145Partial duplication of the phalanx of hand (HP:0009999)1.86246345
146Congenital hepatic fibrosis (HP:0002612)1.84462278
147Tubulointerstitial abnormality (HP:0001969)1.82568189
148Colitis (HP:0002583)1.81295260
149Abnormality of vitamin B metabolism (HP:0004340)1.79618456
150Muscle fiber atrophy (HP:0100295)1.79331861
151CNS demyelination (HP:0007305)1.78818127
152Duplication of thumb phalanx (HP:0009942)1.78729951
153Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78585621
154Male infertility (HP:0003251)1.76858691
155Recurrent bacterial skin infections (HP:0005406)1.76098002
156Retinitis pigmentosa (HP:0000510)1.75661639
157Aplasia/hypoplasia of the uterus (HP:0008684)1.73354032
158Abnormal number of erythroid precursors (HP:0012131)1.72603416
159Oligodactyly (hands) (HP:0001180)1.71666191
160Preaxial hand polydactyly (HP:0001177)1.71013518
161Lower limb asymmetry (HP:0100559)1.70985675
162Abnormal spermatogenesis (HP:0008669)1.70659377
163Abnormality of molar morphology (HP:0011070)1.70459387
164Abnormality of molar (HP:0011077)1.70459387
165Abnormality of dentin (HP:0010299)1.69353956
166Vasculitis (HP:0002633)1.69157469
167Midline defect of the nose (HP:0004122)1.68516493
168Orchitis (HP:0100796)1.68508291
169Intestinal fistula (HP:0100819)1.68090058
170Chronic diarrhea (HP:0002028)1.66071307
171Central scotoma (HP:0000603)1.65205247
172Postaxial foot polydactyly (HP:0001830)1.63745201
173Abnormality of the dental pulp (HP:0006479)1.62261921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.85675923
2VRK23.58999546
3PLK43.55436262
4PHKG23.52380264
5PHKG13.52380264
6MAP4K23.40619385
7NEK93.29380882
8EEF2K2.97496172
9MAPK152.87998836
10BCKDK2.82948461
11ERN12.48563254
12TXK2.42414872
13BUB12.34177648
14TRIB32.24417423
15NME22.23047194
16PLK22.22567656
17VRK12.16647943
18MAP4K12.12454111
19ZAK2.07776748
20ERBB31.93678335
21MAPK71.93442173
22DYRK31.91197589
23ICK1.88381997
24WNK31.87665307
25INSRR1.87214638
26CAMK1G1.87119492
27MAP3K121.86602405
28CDK191.85431726
29TIE11.84462123
30KDR1.84077862
31TRIM281.81051019
32EIF2AK31.80084013
33CAMK1D1.71024779
34TESK11.67887941
35PRKD31.66470753
36CCNB11.65691748
37ADRBK21.65280633
38NME11.60046380
39PDK31.56799233
40PDK41.56799233
41SIK21.55171515
42ARAF1.54262322
43TLK11.53980892
44EIF2AK11.52745091
45NEK11.50744529
46RPS6KA41.46740215
47MATK1.45541525
48PIM21.36117525
49RPS6KA21.34859986
50CSNK1A1L1.33289702
51LMTK21.32869173
52BRSK21.31622709
53PBK1.27843313
54MAPKAPK31.25412685
55DDR21.23972580
56GRK71.23581864
57CAMK2B1.23348768
58RIPK11.21821534
59RIPK41.20745514
60LIMK11.17068856
61MAP2K21.16762693
62NUAK11.15631614
63PLK31.15552690
64HIPK21.14838782
65CAMK2D1.13453416
66PAK31.12701978
67MST41.12034377
68PRKAA21.11610459
69MAPK121.10694825
70PDK11.06546544
71MYLK1.06484666
72CSNK1G31.04935886
73GRK11.04064333
74BRSK11.02818933
75MUSK1.02699594
76CAMKK11.02362246
77BMPR21.01379098
78SRPK10.99310178
79CDK90.96237511
80PIK3CG0.94596655
81CAMK2G0.90596490
82IRAK30.88802347
83NEK60.88002012
84CAMKK20.86774079
85CSNK1G10.85498896
86PDPK10.83558255
87WEE10.83434675
88ACVR1B0.82099964
89CDK80.80011812
90STK38L0.77688417
91PLK10.77390391
92CDK120.77000238
93IKBKE0.75990216
94IRAK10.75385094
95PNCK0.74976614
96CDK60.74804225
97TYK20.73910436
98MAPKAPK20.70406760
99TGFBR10.69407558
100CSNK1G20.68930382
101PASK0.68653840
102TESK20.67486376
103DAPK30.63451619
104DYRK1B0.62311271
105STK240.61350873
106BLK0.61215205
107PINK10.60604501
108ABL20.60507335
109EPHB20.60015674
110IKBKB0.57853772
111MAP3K110.57558723
112CDC70.56718435
113AURKB0.54799872
114CSNK2A10.54783070
115MAPKAPK50.53902657
116SYK0.53433730
117STK390.52395149
118PRKCE0.52347446
119CSF1R0.51632750
120ADRBK10.50432500
121FRK0.49127727
122AURKA0.48593684
123NEK20.47645193
124STK110.47528920
125RPS6KA60.46508770
126TGFBR20.46141933
127CHEK20.46134728
128RPS6KC10.45682810
129RPS6KL10.45682810
130FLT30.45564782
131TBK10.45433340
132CDK30.44316634
133JAK10.44228342
134WNK40.43791857
135BMPR1B0.42842019
136TAF10.42630284
137MAP3K50.41990113
138DAPK20.41789561
139TRPM70.41783419
140CSNK2A20.41766010
141DYRK20.41014615
142IRAK20.40324245
143MAP3K100.40275781
144ROCK10.37431143
145MARK20.36825487
146STK160.36376661
147CSNK1A10.36139650
148CSK0.35692848
149SGK20.35668063
150PRKCQ0.35656864
151HCK0.35485642
152MAP3K70.35382872
153MAP2K60.34984535
154MAPK110.34929229
155SGK4940.34890392
156SGK2230.34890392
157MKNK10.34688932
158MAPK130.34496531
159GRK60.33185615
160CAMK40.32856273
161PRKG10.32719374
162PIM10.32657992
163OXSR10.31763003
164TTK0.31467603
165PTK2B0.31420109
166AKT30.29396207
167PRKCZ0.28339622
168SGK30.28158645
169PKN10.27338169
170GRK50.26493438
171RPS6KA50.25103165
172MAP3K40.25030638
173PRKACA0.24897252
174CDK70.24878047

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.08546505
2Proteasome_Homo sapiens_hsa030503.85596564
3Protein export_Homo sapiens_hsa030603.68640482
4Ribosome_Homo sapiens_hsa030103.37566000
5Parkinsons disease_Homo sapiens_hsa050123.33671642
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.12621607
7Other glycan degradation_Homo sapiens_hsa005113.06811734
8Huntingtons disease_Homo sapiens_hsa050162.47349024
9RNA polymerase_Homo sapiens_hsa030202.31173777
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.21760588
11Alzheimers disease_Homo sapiens_hsa050102.19982688
12Homologous recombination_Homo sapiens_hsa034402.05909983
13Olfactory transduction_Homo sapiens_hsa0474010.8050811
14Mismatch repair_Homo sapiens_hsa034301.99575397
15Fanconi anemia pathway_Homo sapiens_hsa034601.93239955
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.91326055
17Phototransduction_Homo sapiens_hsa047441.87952330
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80694379
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80312766
20Nucleotide excision repair_Homo sapiens_hsa034201.77453931
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73862637
22B cell receptor signaling pathway_Homo sapiens_hsa046621.63267335
23Ether lipid metabolism_Homo sapiens_hsa005651.62555347
24Taste transduction_Homo sapiens_hsa047421.52945374
25DNA replication_Homo sapiens_hsa030301.51668074
26Insulin secretion_Homo sapiens_hsa049111.51101203
27Pyrimidine metabolism_Homo sapiens_hsa002401.50793385
28Base excision repair_Homo sapiens_hsa034101.50578075
29Butanoate metabolism_Homo sapiens_hsa006501.49011651
30Cardiac muscle contraction_Homo sapiens_hsa042601.47910763
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.46205771
32Folate biosynthesis_Homo sapiens_hsa007901.43460807
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43110849
34Asthma_Homo sapiens_hsa053101.42118930
35Glutathione metabolism_Homo sapiens_hsa004801.41877088
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40540046
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36702843
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35952651
39Sulfur metabolism_Homo sapiens_hsa009201.35824356
40cAMP signaling pathway_Homo sapiens_hsa040241.35060884
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34498554
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28658717
43Collecting duct acid secretion_Homo sapiens_hsa049661.27695694
44Peroxisome_Homo sapiens_hsa041461.26835531
45Sulfur relay system_Homo sapiens_hsa041221.26554864
46Fatty acid elongation_Homo sapiens_hsa000621.24307975
47Morphine addiction_Homo sapiens_hsa050321.23571905
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22386677
49Arachidonic acid metabolism_Homo sapiens_hsa005901.21848192
50Allograft rejection_Homo sapiens_hsa053301.21346399
51Renin secretion_Homo sapiens_hsa049241.20146580
52Glucagon signaling pathway_Homo sapiens_hsa049221.20036562
53Autoimmune thyroid disease_Homo sapiens_hsa053201.17405555
54Circadian entrainment_Homo sapiens_hsa047131.09916325
55Salivary secretion_Homo sapiens_hsa049701.08643610
56Spliceosome_Homo sapiens_hsa030401.06677690
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06278125
58Glutamatergic synapse_Homo sapiens_hsa047241.06277560
59Estrogen signaling pathway_Homo sapiens_hsa049151.04882296
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03559167
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02032789
62Platelet activation_Homo sapiens_hsa046111.01442758
63Fatty acid biosynthesis_Homo sapiens_hsa000611.01277837
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99321068
65Rheumatoid arthritis_Homo sapiens_hsa053230.99219482
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98638590
67RNA transport_Homo sapiens_hsa030130.98304023
68Calcium signaling pathway_Homo sapiens_hsa040200.97928423
69Ovarian steroidogenesis_Homo sapiens_hsa049130.97298779
70GnRH signaling pathway_Homo sapiens_hsa049120.95170698
71Sphingolipid metabolism_Homo sapiens_hsa006000.94820514
72Basal transcription factors_Homo sapiens_hsa030220.93133320
73Tryptophan metabolism_Homo sapiens_hsa003800.93057581
74RNA degradation_Homo sapiens_hsa030180.92786320
75Type I diabetes mellitus_Homo sapiens_hsa049400.92269853
76Gastric acid secretion_Homo sapiens_hsa049710.92182553
77Staphylococcus aureus infection_Homo sapiens_hsa051500.91560542
78Metabolic pathways_Homo sapiens_hsa011000.90377716
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89878741
80Antigen processing and presentation_Homo sapiens_hsa046120.88937662
81N-Glycan biosynthesis_Homo sapiens_hsa005100.87213111
82Cholinergic synapse_Homo sapiens_hsa047250.85436688
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84113810
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80359489
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79215048
86Dopaminergic synapse_Homo sapiens_hsa047280.78954557
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.78901120
88Purine metabolism_Homo sapiens_hsa002300.78188236
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77873385
90Non-homologous end-joining_Homo sapiens_hsa034500.77712193
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77597234
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.77359466
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77235001
94Pancreatic cancer_Homo sapiens_hsa052120.76525958
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.76278421
96Thyroid hormone synthesis_Homo sapiens_hsa049180.74509233
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74429465
98Regulation of autophagy_Homo sapiens_hsa041400.73193895
99Lysosome_Homo sapiens_hsa041420.73141595
100Steroid biosynthesis_Homo sapiens_hsa001000.72990285
101One carbon pool by folate_Homo sapiens_hsa006700.70200816
102Vitamin B6 metabolism_Homo sapiens_hsa007500.69862011
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69839482
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69740330
105Graft-versus-host disease_Homo sapiens_hsa053320.68834052
106Chemokine signaling pathway_Homo sapiens_hsa040620.68626078
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67526400
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67409513
109Bile secretion_Homo sapiens_hsa049760.67239189
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.64422806
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63037107
112Tuberculosis_Homo sapiens_hsa051520.62160373
113Amphetamine addiction_Homo sapiens_hsa050310.61664139
114Legionellosis_Homo sapiens_hsa051340.61411313
115Chronic myeloid leukemia_Homo sapiens_hsa052200.58091353
116Oocyte meiosis_Homo sapiens_hsa041140.58088692
117Osteoclast differentiation_Homo sapiens_hsa043800.57967986
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57755827
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57342577
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57138628
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57011182
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56946646
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56367876
124Dorso-ventral axis formation_Homo sapiens_hsa043200.56055114
125Pancreatic secretion_Homo sapiens_hsa049720.55905119
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.55070917
127Fatty acid degradation_Homo sapiens_hsa000710.54729094
128Notch signaling pathway_Homo sapiens_hsa043300.52866640
129Oxytocin signaling pathway_Homo sapiens_hsa049210.47754593
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47511091
131Gap junction_Homo sapiens_hsa045400.47223378
132Fatty acid metabolism_Homo sapiens_hsa012120.46560810
133Selenocompound metabolism_Homo sapiens_hsa004500.46545731
134Propanoate metabolism_Homo sapiens_hsa006400.46513745
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45312482
136Systemic lupus erythematosus_Homo sapiens_hsa053220.45248120
137ABC transporters_Homo sapiens_hsa020100.45212409
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44334934
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43445751
140Insulin signaling pathway_Homo sapiens_hsa049100.43292444
141T cell receptor signaling pathway_Homo sapiens_hsa046600.43149814
142Viral carcinogenesis_Homo sapiens_hsa052030.43100955
143Carbon metabolism_Homo sapiens_hsa012000.42664334
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42322568
145Primary immunodeficiency_Homo sapiens_hsa053400.41852292
146Alcoholism_Homo sapiens_hsa050340.41810261
147Pyruvate metabolism_Homo sapiens_hsa006200.41167190
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41126072
149Non-small cell lung cancer_Homo sapiens_hsa052230.40099831
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39742339
151Vibrio cholerae infection_Homo sapiens_hsa051100.39662895
152Chemical carcinogenesis_Homo sapiens_hsa052040.39213327
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38879796
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38872154
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37801168
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35844303
157Prostate cancer_Homo sapiens_hsa052150.35065459
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35040926
159Nitrogen metabolism_Homo sapiens_hsa009100.34902467
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.33061116
161Mineral absorption_Homo sapiens_hsa049780.32761640
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.32381052
163Glioma_Homo sapiens_hsa052140.32329051
164Long-term potentiation_Homo sapiens_hsa047200.32249915
165Apoptosis_Homo sapiens_hsa042100.32202651
166Maturity onset diabetes of the young_Homo sapiens_hsa049500.31866632
167GABAergic synapse_Homo sapiens_hsa047270.31470409
168Toxoplasmosis_Homo sapiens_hsa051450.31311887
169Endometrial cancer_Homo sapiens_hsa052130.30674421
170Acute myeloid leukemia_Homo sapiens_hsa052210.30529280
171Retinol metabolism_Homo sapiens_hsa008300.29343532
172Phospholipase D signaling pathway_Homo sapiens_hsa040720.29334965
173Jak-STAT signaling pathway_Homo sapiens_hsa046300.28607223
174Hematopoietic cell lineage_Homo sapiens_hsa046400.28294395
175beta-Alanine metabolism_Homo sapiens_hsa004100.28036447
176Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26142843
177Phagosome_Homo sapiens_hsa041450.23599162
178Steroid hormone biosynthesis_Homo sapiens_hsa001400.22088188
179Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20866774

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