DYTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.20033312
2protein neddylation (GO:0045116)6.45084440
3adenine nucleotide transport (GO:0051503)5.61394502
4neutrophil activation involved in immune response (GO:0002283)5.59884613
5purine ribonucleotide transport (GO:0015868)5.44093335
6doxorubicin metabolic process (GO:0044598)5.32988083
7daunorubicin metabolic process (GO:0044597)5.32988083
8polyketide metabolic process (GO:0030638)5.32988083
9negative regulation of calcium ion transport into cytosol (GO:0010523)5.31262652
10regulation of female receptivity (GO:0045924)5.20586256
11oxygen transport (GO:0015671)4.88868478
12positive regulation of B cell differentiation (GO:0045579)4.76400743
13purine nucleotide transport (GO:0015865)4.73508929
14kidney morphogenesis (GO:0060993)4.73382575
15female mating behavior (GO:0060180)4.68920044
16endothelium development (GO:0003158)4.68577510
17blood coagulation, intrinsic pathway (GO:0007597)4.60011062
18angiogenesis involved in wound healing (GO:0060055)4.49180988
19purinergic nucleotide receptor signaling pathway (GO:0035590)4.47810198
20regulation of platelet activation (GO:0010543)4.47607096
21regulation of platelet aggregation (GO:0090330)4.33259420
22G-protein coupled receptor internalization (GO:0002031)4.23882268
23megakaryocyte development (GO:0035855)4.22598300
24detection of molecule of bacterial origin (GO:0032490)4.18089434
25positive regulation by symbiont of host defense response (GO:0052509)4.13631577
26modulation by symbiont of host defense response (GO:0052031)4.13631577
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13631577
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13631577
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.13631577
30modulation by symbiont of host immune response (GO:0052553)4.13631577
31platelet aggregation (GO:0070527)4.08907056
32aggressive behavior (GO:0002118)4.07587956
33negative regulation of thymocyte apoptotic process (GO:0070244)4.04442106
34negative regulation of mast cell activation (GO:0033004)4.03741716
35cilium movement (GO:0003341)4.03663308
36eosinophil chemotaxis (GO:0048245)3.94283207
37negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.92133115
38motile cilium assembly (GO:0044458)3.91342679
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.91245059
40lipoxygenase pathway (GO:0019372)3.86021433
41positive regulation of mast cell activation (GO:0033005)3.83957462
42regulation of integrin activation (GO:0033623)3.77597732
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.75227046
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74988519
45positive regulation of granulocyte differentiation (GO:0030854)3.71081575
46negative regulation of heart rate (GO:0010459)3.69368011
47axoneme assembly (GO:0035082)3.68683120
48negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.68341473
49regulation of pigment cell differentiation (GO:0050932)3.60802151
50positive regulation of systemic arterial blood pressure (GO:0003084)3.59733019
51definitive hemopoiesis (GO:0060216)3.58930065
52nucleoside transport (GO:0015858)3.57411052
53cellular anion homeostasis (GO:0030002)3.49824450
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.45791480
55eosinophil migration (GO:0072677)3.44596503
56regulation of non-canonical Wnt signaling pathway (GO:2000050)3.44308625
57left/right axis specification (GO:0070986)3.43864766
58cyclooxygenase pathway (GO:0019371)3.43412287
59opioid receptor signaling pathway (GO:0038003)3.43339557
60axonemal dynein complex assembly (GO:0070286)3.42000472
61fusion of sperm to egg plasma membrane (GO:0007342)3.41225623
62inner ear receptor stereocilium organization (GO:0060122)3.40472925
63purinergic receptor signaling pathway (GO:0035587)3.40318404
64autophagic vacuole fusion (GO:0000046)3.38928306
65pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.38843372
66positive regulation of endothelial cell differentiation (GO:0045603)3.37573859
67maternal behavior (GO:0042711)3.37528654
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33043982
69response to host immune response (GO:0052572)3.33043982
70negative regulation of interleukin-17 production (GO:0032700)3.32314426
71regulation of activation of Janus kinase activity (GO:0010533)3.32302846
72relaxation of smooth muscle (GO:0044557)3.31247909
73Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30557312
74leukocyte migration involved in inflammatory response (GO:0002523)3.28043483
75adenosine receptor signaling pathway (GO:0001973)3.26147060
76neutrophil activation (GO:0042119)3.24604263
77microglial cell activation (GO:0001774)3.22461124
78phagocytosis, engulfment (GO:0006911)3.19076024
79negative regulation of norepinephrine secretion (GO:0010700)3.18659691
80grooming behavior (GO:0007625)3.17292209
81regulation of Golgi to plasma membrane protein transport (GO:0042996)3.15141734
82positive regulation of heat generation (GO:0031652)3.15079299
83pyrimidine nucleotide catabolic process (GO:0006244)3.14364562
84nucleotide transport (GO:0006862)3.12441973
85aminoglycoside antibiotic metabolic process (GO:0030647)3.09610668
86positive regulation of cellular amide metabolic process (GO:0034250)3.08867710
87monoamine transport (GO:0015844)3.08088687
88post-embryonic morphogenesis (GO:0009886)3.05857024
89regulation of integrin-mediated signaling pathway (GO:2001044)3.05551230
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04691919
91purine-containing compound salvage (GO:0043101)3.04608667
92dopaminergic neuron differentiation (GO:0071542)3.04577572
93regulation of lipoprotein metabolic process (GO:0050746)3.04448199
94parental behavior (GO:0060746)3.02811236
95negative regulation of myeloid cell apoptotic process (GO:0033033)3.02709827
96negative regulation of T cell apoptotic process (GO:0070233)3.01144923
97regulation of response to tumor cell (GO:0002834)3.00315346
98positive regulation of response to tumor cell (GO:0002836)3.00315346
99positive regulation of immune response to tumor cell (GO:0002839)3.00315346
100regulation of immune response to tumor cell (GO:0002837)3.00315346
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97562286
102response to host (GO:0075136)2.97562286
103response to host defenses (GO:0052200)2.97562286
104negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.97043546
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.96920305
106positive regulation of developmental pigmentation (GO:0048087)2.96887072
107cerebral cortex radially oriented cell migration (GO:0021799)2.95553555
108adenosine metabolic process (GO:0046085)2.95292562
109B cell mediated immunity (GO:0019724)2.94350081
110limb bud formation (GO:0060174)2.93395767
111low-density lipoprotein particle remodeling (GO:0034374)2.91970428
112DNA strand renaturation (GO:0000733)2.91587750
113fat-soluble vitamin catabolic process (GO:0042363)2.90742326
114vitamin catabolic process (GO:0009111)2.90742326
115sleep (GO:0030431)2.90726046
116regulation of norepinephrine secretion (GO:0014061)2.88394733
117epithelial cilium movement (GO:0003351)2.88342322
118detection of external biotic stimulus (GO:0098581)2.85840868
119regulation of mitochondrial depolarization (GO:0051900)2.84816266
120piRNA metabolic process (GO:0034587)2.84735808
121gas transport (GO:0015669)2.84660298
122positive regulation of blood coagulation (GO:0030194)2.84596053
123positive regulation of hemostasis (GO:1900048)2.84596053
124pyrimidine nucleoside catabolic process (GO:0046135)2.84510281
125negative regulation of platelet activation (GO:0010544)2.84433551
126regulation of transmission of nerve impulse (GO:0051969)2.82197278
127positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81751800
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80329029
129dopamine transport (GO:0015872)2.76595455
130actin nucleation (GO:0045010)2.76357633
131negative regulation of stress fiber assembly (GO:0051497)2.76083162
132homotypic cell-cell adhesion (GO:0034109)2.76001541
133reflex (GO:0060004)2.75972237
134regulation of B cell apoptotic process (GO:0002902)2.75536942
135immunoglobulin mediated immune response (GO:0016064)2.75429341
136beta-amyloid metabolic process (GO:0050435)2.75407264
137DNA deamination (GO:0045006)2.72719500
138regulation of somitogenesis (GO:0014807)2.71960966
139regulation of macrophage derived foam cell differentiation (GO:0010743)2.71803831
140cardiolipin metabolic process (GO:0032048)2.70383668
141regulation of B cell differentiation (GO:0045577)2.70197198
142deoxyribonucleotide catabolic process (GO:0009264)2.70123099
143granulocyte activation (GO:0036230)2.70094841
144positive regulation of interleukin-1 beta secretion (GO:0050718)2.69746538
145negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69666858
146plasma membrane fusion (GO:0045026)2.68191933
147regulation of mast cell activation involved in immune response (GO:0033006)2.67664307
148centriole assembly (GO:0098534)2.65710586
149negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64246627
150regulation of interferon-beta biosynthetic process (GO:0045357)2.63968078
151membrane invagination (GO:0010324)2.63929934
152regulation of MHC class II biosynthetic process (GO:0045346)2.63714433
153regulation of cholesterol efflux (GO:0010874)2.62939460
154platelet formation (GO:0030220)2.62717096
155regulation of T-helper 1 cell differentiation (GO:0045625)2.62113722
156detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61783564
157organelle membrane fusion (GO:0090174)2.61679200
158deoxyribose phosphate catabolic process (GO:0046386)2.61389784
159histamine secretion (GO:0001821)2.60082765
160superoxide anion generation (GO:0042554)2.58104217
161auditory receptor cell stereocilium organization (GO:0060088)2.57946180
162vocalization behavior (GO:0071625)2.56864431
163activated T cell proliferation (GO:0050798)2.56670015
164cilium assembly (GO:0042384)2.55943758
165regulation of fever generation (GO:0031620)2.55369979
166cellular response to exogenous dsRNA (GO:0071360)2.53389615
167negative regulation of interleukin-10 production (GO:0032693)2.53331727
168dendritic cell chemotaxis (GO:0002407)2.52619746
169positive regulation of uterine smooth muscle contraction (GO:0070474)2.52481851
170regulation of mast cell degranulation (GO:0043304)2.49758610
171cilium organization (GO:0044782)2.49187854
172detection of biotic stimulus (GO:0009595)2.47903579
173regulation of mast cell activation (GO:0033003)2.45139422
174positive regulation of interleukin-1 secretion (GO:0050716)2.44932243
175positive regulation of mast cell activation involved in immune response (GO:0033008)2.42768762
176positive regulation of mast cell degranulation (GO:0043306)2.42768762
177ionotropic glutamate receptor signaling pathway (GO:0035235)2.41366255
178trivalent inorganic anion homeostasis (GO:0072506)2.40871357
179phosphate ion homeostasis (GO:0055062)2.40871357
180positive regulation of defense response to virus by host (GO:0002230)2.40288033
181dentate gyrus development (GO:0021542)2.39762378
182mechanoreceptor differentiation (GO:0042490)2.39581895
183T cell lineage commitment (GO:0002360)2.37006610
184sympathetic nervous system development (GO:0048485)2.35876463
185regulation of interleukin-6 biosynthetic process (GO:0045408)2.35851233
186inner ear receptor cell differentiation (GO:0060113)2.35435667
187retina layer formation (GO:0010842)2.34590264
188detection of mechanical stimulus involved in sensory perception (GO:0050974)2.34313931
189regulation of myeloid cell apoptotic process (GO:0033032)2.33447226
190positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.32799057
191cilium or flagellum-dependent cell motility (GO:0001539)2.32656264
192negative regulation of myoblast differentiation (GO:0045662)2.32400650
193negative regulation of leukocyte migration (GO:0002686)2.32346463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.45185171
2SCL_19346495_ChIP-Seq_HPC-7_Human4.76629729
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.19432192
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.16873972
5GBX2_23144817_ChIP-Seq_PC3_Human3.95493907
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.83801353
7SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.74769918
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.29599335
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.28464609
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99501599
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88629265
12LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.87408033
13EZH2_22144423_ChIP-Seq_EOC_Human2.86673783
14GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.84702747
15GATA1_22025678_ChIP-Seq_K562_Human2.80898479
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77252837
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.58484643
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56898932
19GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.28124746
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25940685
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.19852100
22GATA1_19941826_ChIP-Seq_K562_Human2.18507697
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10554620
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09531593
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.08321635
26TAF15_26573619_Chip-Seq_HEK293_Human2.06968380
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06866523
28GATA1_19941827_ChIP-Seq_MEL_Mouse2.06162689
29* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02358460
30* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99655777
31SPI1_23127762_ChIP-Seq_K562_Human1.98411383
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98256764
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.96975068
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96693837
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96467793
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96049712
37P300_19829295_ChIP-Seq_ESCs_Human1.95435701
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92408746
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.91453703
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89639013
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86434398
42* NANOG_18555785_Chip-Seq_ESCs_Mouse1.84422708
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83662641
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.83662641
45* NFE2_27457419_Chip-Seq_LIVER_Mouse1.80790674
46* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80760019
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80499485
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80499485
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.80120328
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78957824
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78666011
52* FLI1_27457419_Chip-Seq_LIVER_Mouse1.77348013
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76744823
54* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.76470300
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76298475
56GATA2_19941826_ChIP-Seq_K562_Human1.76031843
57* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73472471
58* P53_22387025_ChIP-Seq_ESCs_Mouse1.72213780
59* E2F1_18555785_Chip-Seq_ESCs_Mouse1.71945386
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70292868
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66864600
62SMAD4_21799915_ChIP-Seq_A2780_Human1.66811228
63FUS_26573619_Chip-Seq_HEK293_Human1.65709894
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.65168024
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.64798973
66* CMYC_18555785_Chip-Seq_ESCs_Mouse1.63010716
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.61511975
68SPI1_23547873_ChIP-Seq_NB4_Human1.61451084
69MYB_26560356_Chip-Seq_TH2_Human1.60684333
70VDR_22108803_ChIP-Seq_LS180_Human1.59279635
71RNF2_27304074_Chip-Seq_NSC_Mouse1.57882751
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57834352
73* EZH2_27294783_Chip-Seq_NPCs_Mouse1.57638067
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56635110
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56511115
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.56206771
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55352861
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53811396
79HTT_18923047_ChIP-ChIP_STHdh_Human1.51732113
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51131771
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49725091
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49720778
83* NMYC_18555785_Chip-Seq_ESCs_Mouse1.49504936
84* P300_18555785_Chip-Seq_ESCs_Mouse1.48911206
85* STAT3_18555785_Chip-Seq_ESCs_Mouse1.48475352
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47352560
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47125179
88IGF1R_20145208_ChIP-Seq_DFB_Human1.46033760
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45593882
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45521568
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45026657
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44443063
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44277922
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44183018
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44083059
96* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43421153
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42517056
98* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42180772
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42045380
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41988459
101ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41936628
102* OCT4_18555785_Chip-Seq_ESCs_Mouse1.41422879
103* SOX2_18555785_Chip-Seq_ESCs_Mouse1.41290297
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.40735571
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40331725
106RUNX_20019798_ChIP-Seq_JUKART_Human1.39951005
107* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39761702
108STAT3_23295773_ChIP-Seq_U87_Human1.39086744
109GATA3_26560356_Chip-Seq_TH2_Human1.38898025
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38356837
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38255205
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38199227
113TP53_18474530_ChIP-ChIP_U2OS_Human1.36365380
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36306195
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36277517
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36166887
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35347035
118* ZFX_18555785_Chip-Seq_ESCs_Mouse1.34824908
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34435150
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34337085
121JUN_21703547_ChIP-Seq_K562_Human1.34143566
122KDM2B_26808549_Chip-Seq_REH_Human1.33155513
123* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30586196
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30021636
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.29849463
126SPI1_20517297_ChIP-Seq_HL60_Human1.29215018
127EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29018005
128* PU1_27457419_Chip-Seq_LIVER_Mouse1.28875492
129ER_23166858_ChIP-Seq_MCF-7_Human1.28598715
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28437918
131STAT1_20625510_ChIP-Seq_HELA_Human1.27943083
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27092212
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26945289
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26776798
135AR_21572438_ChIP-Seq_LNCaP_Human1.26402182
136* REST_21632747_ChIP-Seq_MESCs_Mouse1.25578727
137* KLF4_18555785_Chip-Seq_ESCs_Mouse1.25389420
138IRF8_27001747_Chip-Seq_BMDM_Mouse1.25026618
139GATA1_19941827_ChIP-Seq_MEL86_Mouse1.24358768
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23740317
141* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23128240
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22900761
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22054458
144GATA3_27048872_Chip-Seq_THYMUS_Human1.22011773
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21895970
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21231121
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20403261
148EWS_26573619_Chip-Seq_HEK293_Human1.19411402
149SRF_21415370_ChIP-Seq_HL-1_Mouse1.19183646
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19063250
151* CTCF_18555785_Chip-Seq_ESCs_Mouse1.17845491
152TCF4_23295773_ChIP-Seq_U87_Human1.16689428
153AR_25329375_ChIP-Seq_VCAP_Human1.16503782
154TAL1_26923725_Chip-Seq_HPCs_Mouse1.15696193
155RUNX2_22187159_ChIP-Seq_PCA_Human1.15612921
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15522218
157DROSHA_22980978_ChIP-Seq_HELA_Human1.15360242
158AR_20517297_ChIP-Seq_VCAP_Human1.14464087
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14087539
160NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12396511
161ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10706822
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07667575
163NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03771989
164ELF1_20517297_ChIP-Seq_JURKAT_Human1.03616522
165GATA3_21878914_ChIP-Seq_MCF-7_Human1.01627551
166FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99976852
167BCL6_27268052_Chip-Seq_Bcells_Human0.99643459
168STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99338320
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.98912591
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97452387
171E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94871466
172STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92096931
173UTX_26944678_Chip-Seq_JUKART_Human0.90791906
174P300_27268052_Chip-Seq_Bcells_Human0.89030224
175NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86054125
176NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86054125
177NANOG_20526341_ChIP-Seq_ESCs_Human0.84931631
178SALL4_22934838_ChIP-ChIP_CD34+_Human0.83736647
179FOXA1_25329375_ChIP-Seq_VCAP_Human0.83547498
180FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83547498
181ERG_20517297_ChIP-Seq_VCAP_Human0.83473396
182* CEBPB_22108803_ChIP-Seq_LS180_Human0.82543695
183CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81712136
184SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79821262
185IRF1_19129219_ChIP-ChIP_H3396_Human0.79437351
186RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79148385
187VDR_24763502_ChIP-Seq_THP-1_Human0.78241613
188BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77729857
189MYB_26560356_Chip-Seq_TH1_Human0.77372286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.94436289
2MP0003136_yellow_coat_color5.41118199
3MP0000566_synostosis4.94111401
4MP0001986_abnormal_taste_sensitivity4.08333369
5MP0003724_increased_susceptibility_to3.64119066
6MP0005377_hearing/vestibular/ear_phenot3.24037167
7MP0003878_abnormal_ear_physiology3.24037167
8MP0000465_gastrointestinal_hemorrhage3.18312716
9MP0002102_abnormal_ear_morphology3.14246359
10MP0005397_hematopoietic_system_phenotyp2.99737555
11MP0001545_abnormal_hematopoietic_system2.99737555
12MP0005409_darkened_coat_color2.92282530
13MP0001835_abnormal_antigen_presentation2.84625471
14MP0002735_abnormal_chemical_nociception2.73203583
15MP0005451_abnormal_body_composition2.48046640
16MP0003806_abnormal_nucleotide_metabolis2.30576980
17MP0002277_abnormal_respiratory_mucosa2.17171292
18MP0003303_peritoneal_inflammation2.13838130
19MP0001486_abnormal_startle_reflex2.11235434
20MP0001346_abnormal_lacrimal_gland2.04099172
21MP0008775_abnormal_heart_ventricle2.00550772
22MP0006292_abnormal_olfactory_placode1.99803096
23MP0009697_abnormal_copulation1.98629692
24MP0000230_abnormal_systemic_arterial1.96541613
25MP0002938_white_spotting1.94298576
26MP0005410_abnormal_fertilization1.90413727
27MP0003879_abnormal_hair_cell1.86301886
28MP0001188_hyperpigmentation1.84964663
29MP0005084_abnormal_gallbladder_morpholo1.83710783
30MP0001968_abnormal_touch/_nociception1.83000624
31MP0004742_abnormal_vestibular_system1.80506614
32MP0005645_abnormal_hypothalamus_physiol1.80087699
33MP0005000_abnormal_immune_tolerance1.80053699
34MP0002254_reproductive_system_inflammat1.74230248
35MP0000678_abnormal_parathyroid_gland1.72446684
36MP0004270_analgesia1.72260019
37MP0009278_abnormal_bone_marrow1.71820520
38MP0002734_abnormal_mechanical_nocicepti1.70343811
39MP0000026_abnormal_inner_ear1.63424541
40MP0002398_abnormal_bone_marrow1.63033043
41MP0004808_abnormal_hematopoietic_stem1.63028413
42MP0002160_abnormal_reproductive_system1.62621712
43MP0000372_irregular_coat_pigmentation1.61497728
44MP0010155_abnormal_intestine_physiology1.57650410
45MP0008872_abnormal_physiological_respon1.56366973
46MP0001485_abnormal_pinna_reflex1.52964378
47MP0006036_abnormal_mitochondrial_physio1.51564550
48MP0002736_abnormal_nociception_after1.50965800
49MP0002723_abnormal_immune_serum1.50219845
50MP0008004_abnormal_stomach_pH1.48572254
51MP0009745_abnormal_behavioral_response1.47031557
52MP0001800_abnormal_humoral_immune1.46672941
53MP0003828_pulmonary_edema1.45928388
54MP0003718_maternal_effect1.45426268
55MP0002452_abnormal_antigen_presenting1.44947393
56MP0000343_altered_response_to1.44355322
57MP0003436_decreased_susceptibility_to1.43710939
58MP0000579_abnormal_nail_morphology1.42807171
59MP0009765_abnormal_xenobiotic_induced1.40481387
60MP0001963_abnormal_hearing_physiology1.39824735
61MP0002751_abnormal_autonomic_nervous1.38810020
62MP0003638_abnormal_response/metabolism_1.38601959
63MP0000689_abnormal_spleen_morphology1.38589573
64MP0002876_abnormal_thyroid_physiology1.37863101
65MP0009046_muscle_twitch1.37561924
66MP0002420_abnormal_adaptive_immunity1.34053150
67MP0001819_abnormal_immune_cell1.33120919
68MP0010030_abnormal_orbit_morphology1.32590285
69MP0002234_abnormal_pharynx_morphology1.31595049
70MP0002557_abnormal_social/conspecific_i1.31338541
71MP0005058_abnormal_lysosome_morphology1.27970830
72MP0004859_abnormal_synaptic_plasticity1.27556073
73MP0004510_myositis1.25900238
74MP0004133_heterotaxia1.25838782
75MP0009763_increased_sensitivity_to1.25650066
76MP0000049_abnormal_middle_ear1.25566638
77MP0002572_abnormal_emotion/affect_behav1.22754966
78MP0002067_abnormal_sensory_capabilities1.22070241
79MP0002429_abnormal_blood_cell1.21214821
80MP0002249_abnormal_larynx_morphology1.21082667
81MP0002419_abnormal_innate_immunity1.20952717
82MP0005083_abnormal_biliary_tract1.20156083
83MP0003866_abnormal_defecation1.20072355
84MP0005670_abnormal_white_adipose1.19775896
85MP0005257_abnormal_intraocular_pressure1.18416190
86MP0004084_abnormal_cardiac_muscle1.17897275
87MP0005025_abnormal_response_to1.16633361
88MP0002722_abnormal_immune_system1.14517784
89MP0000716_abnormal_immune_system1.14127669
90MP0005165_increased_susceptibility_to1.11850449
91MP0001663_abnormal_digestive_system1.11039973
92MP0005423_abnormal_somatic_nervous1.11022601
93MP0005167_abnormal_blood-brain_barrier1.11003671
94MP0002132_abnormal_respiratory_system1.09785560
95MP0005171_absent_coat_pigmentation1.09646635
96MP0003938_abnormal_ear_development1.09533860
97MP0005389_reproductive_system_phenotype1.07896776
98MP0002653_abnormal_ependyma_morphology1.07475478
99MP0001533_abnormal_skeleton_physiology1.07120226
100MP0003656_abnormal_erythrocyte_physiolo1.06830273
101MP0006035_abnormal_mitochondrial_morpho1.05945555
102MP0002095_abnormal_skin_pigmentation1.05657648
103MP0001845_abnormal_inflammatory_respons1.04744551
104MP0008877_abnormal_DNA_methylation1.04425443
105MP0000778_abnormal_nervous_system1.02619884
106MP0003075_altered_response_to1.02565742
107MP0000383_abnormal_hair_follicle1.02122928
108MP0001851_eye_inflammation1.01569386
109MP0000685_abnormal_immune_system0.99898738
110MP0001293_anophthalmia0.96539717
111MP0003186_abnormal_redox_activity0.95810771
112MP0008789_abnormal_olfactory_epithelium0.95620033
113MP0000015_abnormal_ear_pigmentation0.95497738
114MP0008875_abnormal_xenobiotic_pharmacok0.95388332
115MP0004147_increased_porphyrin_level0.94330222
116MP0002733_abnormal_thermal_nociception0.94148568
117MP0002064_seizures0.94087583
118MP0002184_abnormal_innervation0.93954880
119MP0005671_abnormal_response_to0.93557543
120MP0000467_abnormal_esophagus_morphology0.92292720
121MP0000427_abnormal_hair_cycle0.92153056
122MP0001440_abnormal_grooming_behavior0.91087421
123MP0009333_abnormal_splenocyte_physiolog0.90866044
124MP0002019_abnormal_tumor_incidence0.90068496
125MP0001905_abnormal_dopamine_level0.89032531
126MP0009642_abnormal_blood_homeostasis0.88860963
127MP0002405_respiratory_system_inflammati0.88410710
128MP0004381_abnormal_hair_follicle0.88333398
129MP0001970_abnormal_pain_threshold0.86914675
130MP0001529_abnormal_vocalization0.86685861
131MP0001664_abnormal_digestion0.86365855
132MP0005387_immune_system_phenotype0.86291994
133MP0001790_abnormal_immune_system0.86291994
134MP0002233_abnormal_nose_morphology0.84906762
135MP0010368_abnormal_lymphatic_system0.84758011
136MP0001270_distended_abdomen0.84647218
137MP0006276_abnormal_autonomic_nervous0.84559308
138MP0003937_abnormal_limbs/digits/tail_de0.84077178
139MP0000249_abnormal_blood_vessel0.83442630
140MP0004130_abnormal_muscle_cell0.82695237
141MP0002272_abnormal_nervous_system0.82015674
142MP0001853_heart_inflammation0.81501335
143MP0001765_abnormal_ion_homeostasis0.80647331
144MP0001502_abnormal_circadian_rhythm0.80201145
145MP0009250_abnormal_appendicular_skeleto0.80172313
146MP0003787_abnormal_imprinting0.79759478
147MP0008961_abnormal_basal_metabolism0.79660413
148MP0002752_abnormal_somatic_nervous0.79041486
149MP0005075_abnormal_melanosome_morpholog0.78528644
150MP0004036_abnormal_muscle_relaxation0.78223060
151MP0003137_abnormal_impulse_conducting0.77292091
152MP0000858_altered_metastatic_potential0.77131283
153MP0004484_altered_response_of0.76512659
154MP0005535_abnormal_body_temperature0.76253826
155MP0008874_decreased_physiological_sensi0.76178015
156MP0006082_CNS_inflammation0.75973403
157MP0002089_abnormal_postnatal_growth/wei0.75954059
158MP0004142_abnormal_muscle_tone0.75384067
159MP0002063_abnormal_learning/memory/cond0.75268769
160MP0009764_decreased_sensitivity_to0.75022614
161MP0002148_abnormal_hypersensitivity_rea0.74915556
162MP0002396_abnormal_hematopoietic_system0.74646293
163MP0010329_abnormal_lipoprotein_level0.73980633
164MP0005551_abnormal_eye_electrophysiolog0.73678895
165MP0003763_abnormal_thymus_physiology0.73349775
166MP0009785_altered_susceptibility_to0.72323634
167MP0004947_skin_inflammation0.72295997
168MP0003635_abnormal_synaptic_transmissio0.71084372
169MP0008469_abnormal_protein_level0.70880018
170MP0000358_abnormal_cell_content/0.68279029
171MP0001324_abnormal_eye_pigmentation0.68200928
172MP0000538_abnormal_urinary_bladder0.67839630
173MP0001501_abnormal_sleep_pattern0.67487482
174MP0002697_abnormal_eye_size0.67124780
175MP0005253_abnormal_eye_physiology0.66580199
176MP0001299_abnormal_eye_distance/0.66474717
177MP0000681_abnormal_thyroid_gland0.65066078
178MP0008058_abnormal_DNA_repair0.65009291
179MP0005646_abnormal_pituitary_gland0.64926121

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.98444304
2Petechiae (HP:0000967)7.99215494
3Menorrhagia (HP:0000132)7.74513129
4Increased mean platelet volume (HP:0011877)7.54851818
5Abnormal platelet volume (HP:0011876)7.08352872
6Purpura (HP:0000979)6.96691361
7Abnormal ciliary motility (HP:0012262)6.81837814
8Epistaxis (HP:0000421)6.75294258
9Gingival bleeding (HP:0000225)5.88779075
10Abnormal respiratory motile cilium physiology (HP:0012261)5.44846568
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.62199575
12Absent/shortened dynein arms (HP:0200106)4.62199575
13Impaired platelet aggregation (HP:0003540)4.33042573
14Abnormal platelet function (HP:0011869)4.33042573
15Chronic hepatic failure (HP:0100626)4.27430771
16Febrile seizures (HP:0002373)4.01321709
17Hyperlipoproteinemia (HP:0010980)3.93222950
18True hermaphroditism (HP:0010459)3.90011085
19Dyschromatopsia (HP:0007641)3.87373405
20Abnormal respiratory epithelium morphology (HP:0012253)3.78824009
21Abnormal respiratory motile cilium morphology (HP:0005938)3.78824009
22Abnormality of the heme biosynthetic pathway (HP:0010472)3.71472886
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68891158
24Pancreatic cysts (HP:0001737)3.68646729
25Panhypogammaglobulinemia (HP:0003139)3.68586656
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.60475108
27Hypoplasia of the fovea (HP:0007750)3.60475108
28Decreased central vision (HP:0007663)3.58289189
29Unilateral renal agenesis (HP:0000122)3.49041308
30Abnormality of the prostate (HP:0008775)3.41072137
31Poikilocytosis (HP:0004447)3.38250747
32Abnormality of the fovea (HP:0000493)3.37444537
33Abnormal hair whorl (HP:0010721)3.31089577
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.27254301
35Follicular hyperkeratosis (HP:0007502)3.26732551
36Spontaneous abortion (HP:0005268)3.21819231
37Chromsome breakage (HP:0040012)3.09100814
38Elevated erythrocyte sedimentation rate (HP:0003565)3.06886159
39Chronic otitis media (HP:0000389)3.04284292
40Occipital encephalocele (HP:0002085)2.99296267
41Thrombocytosis (HP:0001894)2.95976052
42Lip pit (HP:0100267)2.90920792
43Pancreatic fibrosis (HP:0100732)2.88356840
44Alopecia of scalp (HP:0002293)2.88241467
45Bruising susceptibility (HP:0000978)2.88028690
46Stomatitis (HP:0010280)2.86179315
47Abnormality of the renal collecting system (HP:0004742)2.84510657
48Generalized aminoaciduria (HP:0002909)2.80401407
49Abnormality of incisor morphology (HP:0011063)2.79697589
50Bile duct proliferation (HP:0001408)2.79576475
51Abnormal biliary tract physiology (HP:0012439)2.79576475
52Cheilitis (HP:0100825)2.77543759
53Septo-optic dysplasia (HP:0100842)2.75083857
54Spontaneous hematomas (HP:0007420)2.74426515
553-Methylglutaconic aciduria (HP:0003535)2.74198568
56Abnormality of transition element cation homeostasis (HP:0011030)2.74194104
57Abnormality of iron homeostasis (HP:0011031)2.73457282
58Congenital hepatic fibrosis (HP:0002612)2.70028467
59Abnormal pupillary function (HP:0007686)2.67311654
60Hepatosplenomegaly (HP:0001433)2.66726305
61Rhinitis (HP:0012384)2.65883009
62Nephronophthisis (HP:0000090)2.65623138
63Aplasia cutis congenita (HP:0001057)2.61777847
64Focal motor seizures (HP:0011153)2.60303752
65Type 2 muscle fiber atrophy (HP:0003554)2.56257200
66Acanthocytosis (HP:0001927)2.56009013
67Autoimmune hemolytic anemia (HP:0001890)2.54963061
68Paralysis (HP:0003470)2.54803494
69Agammaglobulinemia (HP:0004432)2.50387623
70Popliteal pterygium (HP:0009756)2.48104259
71Blepharitis (HP:0000498)2.44223242
72Medial flaring of the eyebrow (HP:0010747)2.41492087
73Abolished electroretinogram (ERG) (HP:0000550)2.40516340
74Arterial thrombosis (HP:0004420)2.39235201
75Cystic liver disease (HP:0006706)2.38564434
76Encephalitis (HP:0002383)2.38539837
77Abnormality of the renal medulla (HP:0100957)2.38347731
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.38135131
79Duplicated collecting system (HP:0000081)2.37437596
80Anomalous pulmonary venous return (HP:0010772)2.37105412
81Muscle fiber atrophy (HP:0100295)2.36049752
82Hyperthyroidism (HP:0000836)2.34073267
83Joint swelling (HP:0001386)2.32949387
84Chronic obstructive pulmonary disease (HP:0006510)2.32170047
85Obstructive lung disease (HP:0006536)2.32170047
86Chronic diarrhea (HP:0002028)2.31981390
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.30700292
88Tinnitus (HP:0000360)2.29316760
89Increased IgM level (HP:0003496)2.28554395
90Hypothermia (HP:0002045)2.26515660
91Hypergonadotropic hypogonadism (HP:0000815)2.24679759
92Abnormality of lateral ventricle (HP:0030047)2.24413356
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.23706753
94Renal dysplasia (HP:0000110)2.23666991
95Attenuation of retinal blood vessels (HP:0007843)2.21990193
96Aplasia/Hypoplasia of the macula (HP:0008059)2.21930261
97Abnormality of midbrain morphology (HP:0002418)2.21027473
98Molar tooth sign on MRI (HP:0002419)2.21027473
99Conjugated hyperbilirubinemia (HP:0002908)2.20993998
100Increased serum ferritin (HP:0003281)2.17155796
101Epileptic encephalopathy (HP:0200134)2.16511882
102Abnormality of the pulmonary veins (HP:0011718)2.15318950
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14462200
104Preaxial hand polydactyly (HP:0001177)2.12928101
105Down-sloping shoulders (HP:0200021)2.11748298
106Tubulointerstitial nephritis (HP:0001970)2.09871774
107Bronchiectasis (HP:0002110)2.08898736
108Visual hallucinations (HP:0002367)2.08563169
109Conjunctival telangiectasia (HP:0000524)2.08186424
110Increased corneal curvature (HP:0100692)2.08185414
111Keratoconus (HP:0000563)2.08185414
112Abnormality of the preputium (HP:0100587)2.07773861
113Dry hair (HP:0011359)2.06881293
114Chest pain (HP:0100749)2.02592082
115Absent septum pellucidum (HP:0001331)2.01388580
116Hip dysplasia (HP:0001385)1.95131189
117Abnormality of the common coagulation pathway (HP:0010990)1.94990354
118Nephrogenic diabetes insipidus (HP:0009806)1.92870044
119Abnormality of male internal genitalia (HP:0000022)1.89905225
120Increased cerebral lipofuscin (HP:0011813)1.89696273
121Nasolacrimal duct obstruction (HP:0000579)1.88840408
122Recurrent corneal erosions (HP:0000495)1.88435121
123Clubbing of toes (HP:0100760)1.86901070
124Congenital sensorineural hearing impairment (HP:0008527)1.84213523
125Progressive sensorineural hearing impairment (HP:0000408)1.83336688
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.82903454
127Recurrent cutaneous fungal infections (HP:0011370)1.81298339
128Chronic mucocutaneous candidiasis (HP:0002728)1.81298339
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80081996
130Abnormality of alanine metabolism (HP:0010916)1.80081996
131Hyperalaninemia (HP:0003348)1.80081996
132Amaurosis fugax (HP:0100576)1.79912007
133Male pseudohermaphroditism (HP:0000037)1.79770784
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79604388
135Dicarboxylic aciduria (HP:0003215)1.79604388
136Abnormality of dental color (HP:0011073)1.78084821
137Nausea (HP:0002018)1.77809865
138Ectropion (HP:0000656)1.77263665
139Parakeratosis (HP:0001036)1.77060310
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77020987
141Recurrent sinusitis (HP:0011108)1.77018580
142Postaxial foot polydactyly (HP:0001830)1.76869315
143Chronic sinusitis (HP:0011109)1.76093916
144Abnormality of DNA repair (HP:0003254)1.75947423
145Atonic seizures (HP:0010819)1.75580256
146Vertigo (HP:0002321)1.75542625
147Central scotoma (HP:0000603)1.74533474
148Abnormality of the parathyroid morphology (HP:0011766)1.74456380
149Astigmatism (HP:0000483)1.74381013
150Recurrent abscess formation (HP:0002722)1.73721472
151Gait imbalance (HP:0002141)1.72947021
152Exotropia (HP:0000577)1.72818157
153Thyroid-stimulating hormone excess (HP:0002925)1.72521601
154Thrombophlebitis (HP:0004418)1.71954448
155Submucous cleft hard palate (HP:0000176)1.71929153
156Mixed hearing impairment (HP:0000410)1.71563325
157Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71183039
158Granulocytopenia (HP:0001913)1.70666312
159Aganglionic megacolon (HP:0002251)1.70526382
160Meckel diverticulum (HP:0002245)1.70270126
161Congenital primary aphakia (HP:0007707)1.70236373
162Recurrent viral infections (HP:0004429)1.70038981
163Tongue fasciculations (HP:0001308)1.69755852
164Oligohydramnios (HP:0001562)1.69460131
165Acute lymphatic leukemia (HP:0006721)1.69014311
166Renal Fanconi syndrome (HP:0001994)1.68630600
167Postaxial hand polydactyly (HP:0001162)1.67791991
168Renal agenesis (HP:0000104)1.67546179
169Abnormality of T cell physiology (HP:0011840)1.67450440
170Growth hormone deficiency (HP:0000824)1.67108396
171Abnormal number of erythroid precursors (HP:0012131)1.65255391
172Anencephaly (HP:0002323)1.64099432
173Nuclear cataract (HP:0100018)1.62917343
174Basal ganglia calcification (HP:0002135)1.62811595
175Abnormality of the septum pellucidum (HP:0007375)1.62406154
176Increased density of long bones (HP:0006392)1.62397130
177Tetany (HP:0001281)1.62197510
178Abnormality of B cell number (HP:0010975)1.60652826
179Portal hypertension (HP:0001409)1.60116977
180Abnormal auditory evoked potentials (HP:0006958)1.58707788
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57117568
182Clumsiness (HP:0002312)1.56326305
183Abnormal delayed hypersensitivity skin test (HP:0002963)1.56176042
184Renal cortical cysts (HP:0000803)1.56169907
185Congenital stationary night blindness (HP:0007642)1.53926249
186Exertional dyspnea (HP:0002875)1.52022705
187Dysautonomia (HP:0002459)1.51248334
188Failure to thrive in infancy (HP:0001531)1.51115652
189Meningitis (HP:0001287)1.49455737
190Cutaneous melanoma (HP:0012056)1.49453718
191IgG deficiency (HP:0004315)1.48680223
192Type I transferrin isoform profile (HP:0003642)1.46187948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.05861225
2TAOK35.05350843
3SIK34.55761859
4TNIK4.21707973
5RIPK43.32901076
6SIK23.16728643
7MKNK12.89261709
8GRK72.81676865
9ADRBK22.76048121
10BCKDK2.73700170
11CASK2.67140048
12CSF1R2.52300605
13SYK2.51712787
14MUSK2.50885809
15BMX2.40806988
16TGFBR22.16689117
17CDK82.06476927
18MAPK132.03474846
19MYLK2.02556641
20MAP4K22.00536108
21PIK3CG1.99107433
22PTK2B1.96706355
23SCYL21.96570078
24FES1.96393116
25TXK1.85921053
26MARK31.84372441
27MAPKAPK31.80856671
28EIF2AK21.80167935
29CLK11.68960612
30TNK21.66732535
31NTRK31.63696016
32TLK11.61176042
33GRK51.60880374
34IKBKB1.60826286
35ZAP701.47552315
36FLT31.40796271
37PLK21.40762002
38DAPK21.36805395
39ZAK1.33823460
40SIK11.33189397
41GRK61.31678513
42MAP4K11.30614002
43BMPR1B1.24093383
44STK38L1.23691575
45MAP2K31.23110249
46RPS6KA41.20967824
47ACVR1B1.17826741
48HCK1.11624196
49LATS11.11613552
50KDR1.10902406
51CCNB11.09027175
52EIF2AK11.08992125
53MAP2K71.06889462
54RIPK11.04262690
55PRPF4B1.03181926
56MATK0.99700804
57IRAK40.97535412
58NME10.96786342
59BRSK10.95400934
60YES10.95241633
61CAMK40.95083671
62SRPK10.93129301
63MAP3K140.92977178
64SGK20.92073641
65IRAK10.89484130
66TESK20.88719745
67EPHB20.87700250
68DAPK10.87394828
69MELK0.84952309
70NTRK20.84482111
71CDK30.83972808
72VRK10.81856477
73PRKCE0.80987078
74VRK20.80811862
75CDC42BPA0.80664521
76DAPK30.80150113
77STK40.79748655
78ADRBK10.79188061
79ILK0.77275672
80PINK10.77184025
81STK160.76049762
82PRKCQ0.75869345
83ITK0.75692991
84STK100.75343372
85PRKCG0.74557931
86TIE10.74322784
87STK30.73983911
88LCK0.72622599
89MAPKAPK50.71494476
90OBSCN0.69741866
91INSRR0.68128152
92PIM20.66717329
93TEC0.64222106
94MAP3K110.63681428
95TRPM70.63612218
96SGK10.63374046
97NUAK10.62546875
98FGR0.59880488
99BMPR20.59312795
100ERBB30.58761392
101FRK0.57874577
102NME20.55663019
103AKT30.55169988
104PRKAA20.52425780
105PHKG20.51782589
106PHKG10.51782589
107CAMK1D0.51550313
108NTRK10.50099191
109PAK10.49630131
110LYN0.49104084
111MARK10.48718554
112SGK2230.48301766
113SGK4940.48301766
114RPS6KA50.46858253
115FER0.46543600
116KIT0.45193783
117SGK30.45157812
118ERBB40.44923227
119BLK0.43900843
120MAP3K120.43312402
121NEK90.42956605
122PKN10.41759903
123STK110.41499067
124ABL10.41336341
125IRAK20.40689647
126IKBKE0.39947217
127LMTK20.39718128
128BTK0.39684429
129TBK10.38672078
130PRKG10.38528083
131GRK10.38419578
132CAMK1G0.37982892
133CSNK1G30.37314483
134MST40.36963680
135PRKD10.36734773
136PRKCA0.36015690
137CSNK1G10.35944472
138CAMK2A0.35228077
139MAP2K60.34572114
140MAP3K50.34304958
141PBK0.33973989
142TSSK60.33926100
143PRKACG0.33225727
144AURKA0.33052373
145ABL20.32766237
146JAK30.31972418
147MAPKAPK20.31965693
148MAPK30.30714737
149PRKACA0.30587789
150PRKACB0.29513333
151IRAK30.29417045
152WNK10.28332262
153RPS6KA20.28244802
154PIM10.28105555
155PDK10.27481848
156FYN0.27433700
157JAK20.26302349
158RPS6KB10.25770690
159SRC0.25457774
160PRKCD0.25255032
161CSNK1A1L0.24841405
162UHMK10.24598664
163CHUK0.24457738
164LRRK20.24419355
165IGF1R0.24015848
166DYRK30.23999101
167MAPK110.21761692

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.78050642
2Nicotine addiction_Homo sapiens_hsa050332.93772697
3Asthma_Homo sapiens_hsa053102.81252999
4Arachidonic acid metabolism_Homo sapiens_hsa005902.64929767
5Hematopoietic cell lineage_Homo sapiens_hsa046402.52096288
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44441785
7Rheumatoid arthritis_Homo sapiens_hsa053232.35504813
8Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.28195097
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.28125248
10Taste transduction_Homo sapiens_hsa047422.27129139
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22726986
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.19106213
13Nitrogen metabolism_Homo sapiens_hsa009102.06367224
14Systemic lupus erythematosus_Homo sapiens_hsa053222.05495964
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94668153
16Morphine addiction_Homo sapiens_hsa050321.90073822
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.87168437
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82420410
19Sulfur metabolism_Homo sapiens_hsa009201.82301600
20Linoleic acid metabolism_Homo sapiens_hsa005911.78120875
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76328437
22Autoimmune thyroid disease_Homo sapiens_hsa053201.70268375
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67018805
24Collecting duct acid secretion_Homo sapiens_hsa049661.65666591
25Ether lipid metabolism_Homo sapiens_hsa005651.63747579
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62297142
27Synaptic vesicle cycle_Homo sapiens_hsa047211.58164866
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57159450
29Steroid biosynthesis_Homo sapiens_hsa001001.49055830
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.44497015
31Glutamatergic synapse_Homo sapiens_hsa047241.43531763
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.42472459
33Olfactory transduction_Homo sapiens_hsa047401.40567337
34Serotonergic synapse_Homo sapiens_hsa047261.40133324
35Phagosome_Homo sapiens_hsa041451.39359926
36Cocaine addiction_Homo sapiens_hsa050301.34952212
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.32046147
38African trypanosomiasis_Homo sapiens_hsa051431.31686420
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31029991
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30937283
41GABAergic synapse_Homo sapiens_hsa047271.27912951
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.23521023
43Tuberculosis_Homo sapiens_hsa051521.22933669
44Circadian entrainment_Homo sapiens_hsa047131.21920621
45Calcium signaling pathway_Homo sapiens_hsa040201.19424300
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.18568065
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18321403
48Antigen processing and presentation_Homo sapiens_hsa046121.18230983
49Fanconi anemia pathway_Homo sapiens_hsa034601.16514406
50Herpes simplex infection_Homo sapiens_hsa051681.16422415
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13934974
52Measles_Homo sapiens_hsa051621.10499338
53Alcoholism_Homo sapiens_hsa050341.07686542
54Notch signaling pathway_Homo sapiens_hsa043301.01393095
55B cell receptor signaling pathway_Homo sapiens_hsa046620.99271828
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99067767
57Renin secretion_Homo sapiens_hsa049240.98742773
58ECM-receptor interaction_Homo sapiens_hsa045120.97043192
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96750318
60Phototransduction_Homo sapiens_hsa047440.96138723
61Long-term depression_Homo sapiens_hsa047300.95426132
62Leishmaniasis_Homo sapiens_hsa051400.95349137
63Chemokine signaling pathway_Homo sapiens_hsa040620.95308754
64Influenza A_Homo sapiens_hsa051640.94235576
65Chemical carcinogenesis_Homo sapiens_hsa052040.93306431
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91279658
67Cholinergic synapse_Homo sapiens_hsa047250.89897878
68Gap junction_Homo sapiens_hsa045400.88846722
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88739999
70Glutathione metabolism_Homo sapiens_hsa004800.88461138
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88458165
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87128217
73Glycerolipid metabolism_Homo sapiens_hsa005610.87086901
74Axon guidance_Homo sapiens_hsa043600.86728856
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82908768
76Peroxisome_Homo sapiens_hsa041460.82796756
77Ovarian steroidogenesis_Homo sapiens_hsa049130.82142849
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82107765
79Type I diabetes mellitus_Homo sapiens_hsa049400.79600038
80Purine metabolism_Homo sapiens_hsa002300.78737767
81Vitamin digestion and absorption_Homo sapiens_hsa049770.77970954
82Sphingolipid metabolism_Homo sapiens_hsa006000.77966125
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77084557
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76700769
85Graft-versus-host disease_Homo sapiens_hsa053320.76048256
86Viral myocarditis_Homo sapiens_hsa054160.76038468
87Insulin secretion_Homo sapiens_hsa049110.75620632
88Pancreatic secretion_Homo sapiens_hsa049720.75565562
89Shigellosis_Homo sapiens_hsa051310.71517726
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70247794
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69016423
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68336698
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68222500
94Fatty acid biosynthesis_Homo sapiens_hsa000610.67697133
95Hepatitis B_Homo sapiens_hsa051610.66456249
96Malaria_Homo sapiens_hsa051440.65549709
97Homologous recombination_Homo sapiens_hsa034400.65209365
98Renin-angiotensin system_Homo sapiens_hsa046140.64855604
99Primary immunodeficiency_Homo sapiens_hsa053400.63939411
100Amphetamine addiction_Homo sapiens_hsa050310.63673969
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63243454
102Allograft rejection_Homo sapiens_hsa053300.61649408
103beta-Alanine metabolism_Homo sapiens_hsa004100.60591238
104ABC transporters_Homo sapiens_hsa020100.60033098
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59785881
106Staphylococcus aureus infection_Homo sapiens_hsa051500.57431697
107Histidine metabolism_Homo sapiens_hsa003400.57103242
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54633975
109Dilated cardiomyopathy_Homo sapiens_hsa054140.54251847
110Fatty acid elongation_Homo sapiens_hsa000620.54246154
111Retinol metabolism_Homo sapiens_hsa008300.52413136
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51539459
113Circadian rhythm_Homo sapiens_hsa047100.51183735
114Ras signaling pathway_Homo sapiens_hsa040140.49884132
115Mismatch repair_Homo sapiens_hsa034300.49470641
116Pyrimidine metabolism_Homo sapiens_hsa002400.49283563
117Melanoma_Homo sapiens_hsa052180.48750090
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48708856
119Inositol phosphate metabolism_Homo sapiens_hsa005620.47761024
120Pentose phosphate pathway_Homo sapiens_hsa000300.46901302
121Salivary secretion_Homo sapiens_hsa049700.46827055
122Dopaminergic synapse_Homo sapiens_hsa047280.46584565
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46526278
124Base excision repair_Homo sapiens_hsa034100.45805842
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45237580
126Salmonella infection_Homo sapiens_hsa051320.42787266
127Legionellosis_Homo sapiens_hsa051340.42583972
128Regulation of autophagy_Homo sapiens_hsa041400.42537849
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41508434
130Toxoplasmosis_Homo sapiens_hsa051450.41255496
131Parkinsons disease_Homo sapiens_hsa050120.40253883
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.40043259
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39889700
134Osteoclast differentiation_Homo sapiens_hsa043800.38939409
135cAMP signaling pathway_Homo sapiens_hsa040240.38531071
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38329181
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38002946
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37481625
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.37202876
140Arginine and proline metabolism_Homo sapiens_hsa003300.35784820
141Phenylalanine metabolism_Homo sapiens_hsa003600.34692082
142Hepatitis C_Homo sapiens_hsa051600.33901136
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33530251
144Endocytosis_Homo sapiens_hsa041440.32524702
145Butanoate metabolism_Homo sapiens_hsa006500.32046147
146Viral carcinogenesis_Homo sapiens_hsa052030.31796566
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30707254
148Oxytocin signaling pathway_Homo sapiens_hsa049210.29578725

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