DZANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. Alternative splicing has been observed for this gene but the full-length nature of additional variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.33236516
2synaptic vesicle maturation (GO:0016188)5.98398694
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.88044236
4locomotory exploration behavior (GO:0035641)5.70083269
5vocalization behavior (GO:0071625)5.59852503
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50643482
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.48485302
8epithelial cilium movement (GO:0003351)5.44908709
9synaptic vesicle exocytosis (GO:0016079)5.43654438
10regulation of synaptic vesicle exocytosis (GO:2000300)5.28688099
11glutamate secretion (GO:0014047)5.20902473
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.13893002
13axonemal dynein complex assembly (GO:0070286)5.02475810
14cilium movement (GO:0003341)5.01689690
15cilium or flagellum-dependent cell motility (GO:0001539)4.98306390
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.94891811
17regulation of glutamate receptor signaling pathway (GO:1900449)4.94224339
18neurotransmitter secretion (GO:0007269)4.84758469
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.74619857
20regulation of synaptic vesicle transport (GO:1902803)4.73564081
21neuronal action potential propagation (GO:0019227)4.70372479
22neuron cell-cell adhesion (GO:0007158)4.65897777
23behavioral response to nicotine (GO:0035095)4.61470737
24axoneme assembly (GO:0035082)4.50530389
25gamma-aminobutyric acid transport (GO:0015812)4.48913670
26protein localization to synapse (GO:0035418)4.44289954
27exploration behavior (GO:0035640)4.42329216
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37587271
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36518779
30regulation of neuronal synaptic plasticity (GO:0048168)4.32424875
31L-fucose metabolic process (GO:0042354)4.27073177
32L-fucose catabolic process (GO:0042355)4.27073177
33fucose catabolic process (GO:0019317)4.27073177
34proline transport (GO:0015824)4.13549650
35synaptic transmission, glutamatergic (GO:0035249)4.12868520
36glutamate receptor signaling pathway (GO:0007215)4.12260962
37neurotransmitter transport (GO:0006836)4.09744087
38neuron-neuron synaptic transmission (GO:0007270)4.08152858
39regulation of cilium movement (GO:0003352)4.07680350
40regulation of synapse structural plasticity (GO:0051823)4.06522645
41response to pheromone (GO:0019236)4.05584248
42neuromuscular process controlling posture (GO:0050884)4.00969253
43cellular potassium ion homeostasis (GO:0030007)3.96615667
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94311466
45neurotransmitter-gated ion channel clustering (GO:0072578)3.93390774
46long-term memory (GO:0007616)3.89132954
47layer formation in cerebral cortex (GO:0021819)3.88059633
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.83212655
49glycine transport (GO:0015816)3.79807325
50regulation of neurotransmitter levels (GO:0001505)3.76849115
51dendritic spine morphogenesis (GO:0060997)3.75160473
52transmission of nerve impulse (GO:0019226)3.72496094
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71631297
54positive regulation of membrane potential (GO:0045838)3.71459715
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68007065
56activation of protein kinase A activity (GO:0034199)3.66447453
57cerebellar Purkinje cell differentiation (GO:0021702)3.63046907
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.60999830
59cilium morphogenesis (GO:0060271)3.58978313
60sodium ion export (GO:0071436)3.57421323
61regulation of postsynaptic membrane potential (GO:0060078)3.56735810
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.56473327
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56305881
64intraciliary transport (GO:0042073)3.55597751
65synaptic vesicle endocytosis (GO:0048488)3.53305646
66cilium organization (GO:0044782)3.53127894
67regulation of neurotransmitter secretion (GO:0046928)3.47564227
68prepulse inhibition (GO:0060134)3.47054189
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.44599254
70neuron recognition (GO:0008038)3.42843734
71cilium assembly (GO:0042384)3.42617043
72regulation of synaptic plasticity (GO:0048167)3.42113442
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40005007
74response to auditory stimulus (GO:0010996)3.39377074
75positive regulation of neurotransmitter transport (GO:0051590)3.37857668
76long-term synaptic potentiation (GO:0060291)3.37269660
77neuromuscular process controlling balance (GO:0050885)3.36991192
78protein localization to cilium (GO:0061512)3.36940310
79auditory behavior (GO:0031223)3.34534394
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33766672
81membrane hyperpolarization (GO:0060081)3.33295735
82protein polyglutamylation (GO:0018095)3.32984004
83membrane depolarization during action potential (GO:0086010)3.31346784
84regulation of neurotransmitter transport (GO:0051588)3.31338243
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29742983
86response to histamine (GO:0034776)3.29212273
87negative regulation of telomere maintenance (GO:0032205)3.28777551
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28323825
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28288869
90neuronal ion channel clustering (GO:0045161)3.27492855
91vesicle transport along microtubule (GO:0047496)3.26902901
92nonmotile primary cilium assembly (GO:0035058)3.25344110
93regulation of vesicle fusion (GO:0031338)3.23574237
94postsynaptic membrane organization (GO:0001941)3.22106191
95membrane depolarization (GO:0051899)3.18546392
96positive regulation of neurotransmitter secretion (GO:0001956)3.18300026
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16773889
98mating behavior (GO:0007617)3.15012480
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13013082
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12155842
101water-soluble vitamin biosynthetic process (GO:0042364)3.11098535
102regulation of synaptic transmission, GABAergic (GO:0032228)3.10949770
103startle response (GO:0001964)3.10055814
104positive regulation of synaptic transmission (GO:0050806)3.09850214
105striatum development (GO:0021756)3.09279434
106platelet dense granule organization (GO:0060155)3.08130730
107adult walking behavior (GO:0007628)3.07924256
108regulation of dendritic spine morphogenesis (GO:0061001)3.07592927
109synaptic transmission (GO:0007268)3.07476372
110L-amino acid import (GO:0043092)3.05003552
111cell communication by electrical coupling (GO:0010644)3.04641942
112axonal fasciculation (GO:0007413)3.04463998
113learning (GO:0007612)3.04093986
114synapse assembly (GO:0007416)3.04040684
115intraspecies interaction between organisms (GO:0051703)3.01955513
116social behavior (GO:0035176)3.01955513
117behavioral response to cocaine (GO:0048148)3.01063289
118regulation of synaptic transmission (GO:0050804)3.01040277
119indole-containing compound catabolic process (GO:0042436)2.99846154
120indolalkylamine catabolic process (GO:0046218)2.99846154
121tryptophan catabolic process (GO:0006569)2.99846154
122neuromuscular process (GO:0050905)2.99692807
123kynurenine metabolic process (GO:0070189)2.99007935
124preassembly of GPI anchor in ER membrane (GO:0016254)2.98808034
125presynaptic membrane assembly (GO:0097105)2.97662563
126positive regulation of synapse maturation (GO:0090129)2.96927202
127motile cilium assembly (GO:0044458)2.96083262
128behavioral fear response (GO:0001662)2.95414661
129behavioral defense response (GO:0002209)2.95414661
130piRNA metabolic process (GO:0034587)2.95159909
131kidney morphogenesis (GO:0060993)2.95071709
132detection of light stimulus involved in sensory perception (GO:0050962)2.94194476
133detection of light stimulus involved in visual perception (GO:0050908)2.94194476
134indolalkylamine metabolic process (GO:0006586)2.90491414
135protein complex biogenesis (GO:0070271)2.86563582
136sperm motility (GO:0030317)2.85120411
137regulation of microtubule-based movement (GO:0060632)2.84960404
138photoreceptor cell maintenance (GO:0045494)2.82276845
139neural tube formation (GO:0001841)2.81825635
140DNA double-strand break processing (GO:0000729)2.80245456
141pyrimidine nucleobase catabolic process (GO:0006208)2.78670830
142left/right axis specification (GO:0070986)2.77955854
143nephron tubule morphogenesis (GO:0072078)2.76112617
144nephron epithelium morphogenesis (GO:0072088)2.76112617
145cellular ketone body metabolic process (GO:0046950)2.75404295
146mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74141725
147mitochondrial respiratory chain complex I assembly (GO:0032981)2.74141725
148NADH dehydrogenase complex assembly (GO:0010257)2.74141725
149DNA deamination (GO:0045006)2.71896388
150presynaptic membrane organization (GO:0097090)2.71620860
151retinal cone cell development (GO:0046549)2.70486379
152spinal cord motor neuron differentiation (GO:0021522)2.67687470
153sulfation (GO:0051923)2.67150609
154positive regulation of oligodendrocyte differentiation (GO:0048714)2.66795530
155cellular component assembly involved in morphogenesis (GO:0010927)2.64675348
156respiratory chain complex IV assembly (GO:0008535)2.64483727
157mitochondrial respiratory chain complex assembly (GO:0033108)2.64416930
158protein neddylation (GO:0045116)2.64104877
159negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63400603
160negative regulation of translation, ncRNA-mediated (GO:0040033)2.63400603
161regulation of translation, ncRNA-mediated (GO:0045974)2.63400603
162protein K11-linked deubiquitination (GO:0035871)2.62849884
163smoothened signaling pathway (GO:0007224)2.62661933
164multicellular organism reproduction (GO:0032504)2.58579137
165nucleobase catabolic process (GO:0046113)2.57967221
166tryptophan metabolic process (GO:0006568)2.56733549
167cornea development in camera-type eye (GO:0061303)2.55084712
168somite development (GO:0061053)2.53455000
169centriole replication (GO:0007099)2.52989955
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.52735503
171replication fork processing (GO:0031297)2.52050269
172protein-cofactor linkage (GO:0018065)2.51761105
173DNA methylation involved in gamete generation (GO:0043046)2.51027672
174regulation of telomere maintenance (GO:0032204)2.50641637
175photoreceptor cell development (GO:0042461)2.49297758
176ketone body metabolic process (GO:1902224)2.48583750
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.45148101
178establishment of protein localization to mitochondrial membrane (GO:0090151)2.44932025
179GPI anchor metabolic process (GO:0006505)2.44601667
180mannosylation (GO:0097502)2.44235998
181regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41969347
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41955920
183tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41955920
184mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41849598
185determination of left/right symmetry (GO:0007368)2.41810461
186neuronal action potential (GO:0019228)2.41150758
187neuron fate determination (GO:0048664)2.40112174
188negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40000601
189retinal ganglion cell axon guidance (GO:0031290)2.39659217
190microtubule bundle formation (GO:0001578)2.39433871
191cytochrome complex assembly (GO:0017004)2.38708264
192rRNA catabolic process (GO:0016075)2.37587117
193rhodopsin mediated signaling pathway (GO:0016056)2.35266344
194inner ear receptor stereocilium organization (GO:0060122)2.35047918
195recombinational repair (GO:0000725)2.34952894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12752689
2GBX2_23144817_ChIP-Seq_PC3_Human3.60055109
3VDR_22108803_ChIP-Seq_LS180_Human3.24483062
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10407015
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03542379
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98771369
7REST_21632747_ChIP-Seq_MESCs_Mouse2.78456565
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67348188
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67348188
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57837751
11DROSHA_22980978_ChIP-Seq_HELA_Human2.57619786
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56208176
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50021569
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.48762613
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48300872
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47338669
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43623912
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.40848680
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26299605
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.26074811
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.25255367
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22569365
23FUS_26573619_Chip-Seq_HEK293_Human2.21073879
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.18061191
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.17814702
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16149072
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.11130510
28EWS_26573619_Chip-Seq_HEK293_Human2.10851728
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.09761908
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08777563
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07746417
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96738948
33TAF15_26573619_Chip-Seq_HEK293_Human1.92087663
34AR_21572438_ChIP-Seq_LNCaP_Human1.89974807
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88059745
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87669444
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85972821
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82233206
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79957864
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75280151
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74777609
42SMAD4_21799915_ChIP-Seq_A2780_Human1.72805967
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70201464
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68068156
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64412357
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61204553
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.60598288
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59594400
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.54470316
50BCAT_22108803_ChIP-Seq_LS180_Human1.53275016
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53264903
52CBP_20019798_ChIP-Seq_JUKART_Human1.52488790
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52488790
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52222649
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52222649
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50116688
57MYC_18940864_ChIP-ChIP_HL60_Human1.48044902
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46236095
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43984102
60IRF1_19129219_ChIP-ChIP_H3396_Human1.43057395
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.42958482
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41345131
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41285617
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40492478
65P300_19829295_ChIP-Seq_ESCs_Human1.39467674
66TP53_22573176_ChIP-Seq_HFKS_Human1.38240797
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.35515183
68ZNF274_21170338_ChIP-Seq_K562_Hela1.35357737
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34757102
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.32429464
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30359843
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.30281581
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29469729
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29038193
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29007597
76TCF4_22108803_ChIP-Seq_LS180_Human1.28716199
77STAT3_23295773_ChIP-Seq_U87_Human1.27223956
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.27174823
79SOX2_19829295_ChIP-Seq_ESCs_Human1.26271872
80NANOG_19829295_ChIP-Seq_ESCs_Human1.26271872
81AR_25329375_ChIP-Seq_VCAP_Human1.25550039
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24154104
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24129802
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.23985251
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22544186
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.22357772
87AR_19668381_ChIP-Seq_PC3_Human1.20052314
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.19996478
89IGF1R_20145208_ChIP-Seq_DFB_Human1.19801406
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19620040
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19415972
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.19415972
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17725778
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.17639946
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17273172
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15835878
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.15694619
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15685514
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14237667
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12568268
101RNF2_27304074_Chip-Seq_NSC_Mouse1.12043692
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11816057
103TCF4_23295773_ChIP-Seq_U87_Human1.11710353
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.11580991
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11202165
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10901563
107ELK1_19687146_ChIP-ChIP_HELA_Human1.09967603
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09657269
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09622390
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09153747
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08469448
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07583498
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06820352
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06260720
115NCOR_22424771_ChIP-Seq_293T_Human1.05610201
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.04674557
117AR_20517297_ChIP-Seq_VCAP_Human1.04589156
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.04566376
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03580897
120P53_22387025_ChIP-Seq_ESCs_Mouse1.01376713
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.01024694
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00999123
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00641609
124RUNX2_22187159_ChIP-Seq_PCA_Human1.00601346
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00321598
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00053027
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.99235664
128HOXB7_26014856_ChIP-Seq_BT474_Human0.99117192
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98362873
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98262480
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97904833
132AHR_22903824_ChIP-Seq_MCF-7_Human0.97810196
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97393618
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97148517
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.96940825
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96205078
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95915123
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95360544
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.93816807
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92502646
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92423487
142ER_23166858_ChIP-Seq_MCF-7_Human0.91340972
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90947968
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.90946511
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90656596
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.90006456
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89193026
148JUN_21703547_ChIP-Seq_K562_Human0.87953561
149TP53_16413492_ChIP-PET_HCT116_Human0.87552235
150KDM2B_26808549_Chip-Seq_K562_Human0.87432624
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.87178994
152RXR_22108803_ChIP-Seq_LS180_Human0.86828832
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84455376
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.84361005
155TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83545386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02675075
2MP0003880_abnormal_central_pattern5.31643185
3MP0003635_abnormal_synaptic_transmissio4.11826512
4MP0009046_muscle_twitch3.57467054
5MP0009745_abnormal_behavioral_response3.52625083
6MP0002064_seizures3.32965488
7MP0004270_analgesia3.31685055
8MP0005423_abnormal_somatic_nervous3.20633777
9MP0002063_abnormal_learning/memory/cond3.17403607
10MP0001968_abnormal_touch/_nociception3.10081451
11MP0003195_calcinosis3.09882601
12MP0008877_abnormal_DNA_methylation3.02038608
13MP0002822_catalepsy2.93469260
14MP0003136_yellow_coat_color2.85390010
15MP0002653_abnormal_ependyma_morphology2.81816857
16MP0002572_abnormal_emotion/affect_behav2.81534626
17MP0002272_abnormal_nervous_system2.73635080
18MP0001486_abnormal_startle_reflex2.70912516
19MP0002734_abnormal_mechanical_nocicepti2.59440352
20MP0006292_abnormal_olfactory_placode2.58649213
21MP0001501_abnormal_sleep_pattern2.52795570
22MP0002102_abnormal_ear_morphology2.32259587
23MP0002736_abnormal_nociception_after2.30086285
24MP0006072_abnormal_retinal_apoptosis2.26677415
25MP0004133_heterotaxia2.17865057
26MP0001440_abnormal_grooming_behavior2.14324176
27MP0005646_abnormal_pituitary_gland2.12257265
28MP0002735_abnormal_chemical_nociception2.11432218
29MP0006276_abnormal_autonomic_nervous2.08593302
30MP0002067_abnormal_sensory_capabilities2.07767547
31MP0002733_abnormal_thermal_nociception2.02911432
32MP0001970_abnormal_pain_threshold2.00754292
33MP0008569_lethality_at_weaning1.91037849
34MP0005645_abnormal_hypothalamus_physiol1.88410404
35MP0004924_abnormal_behavior1.84679109
36MP0005386_behavior/neurological_phenoty1.84679109
37MP0008875_abnormal_xenobiotic_pharmacok1.83988364
38MP0002557_abnormal_social/conspecific_i1.79972010
39MP0002938_white_spotting1.78775505
40MP0003122_maternal_imprinting1.76841963
41MP0009780_abnormal_chondrocyte_physiolo1.76638206
42MP0002909_abnormal_adrenal_gland1.74903421
43MP0005253_abnormal_eye_physiology1.74222295
44MP0002184_abnormal_innervation1.73288545
45MP0003787_abnormal_imprinting1.68063017
46MP0004811_abnormal_neuron_physiology1.66787640
47MP0003878_abnormal_ear_physiology1.65819926
48MP0005377_hearing/vestibular/ear_phenot1.65819926
49MP0001529_abnormal_vocalization1.63343343
50MP0001984_abnormal_olfaction1.61080217
51MP0003879_abnormal_hair_cell1.58945452
52MP0008789_abnormal_olfactory_epithelium1.57348873
53MP0004142_abnormal_muscle_tone1.56214443
54MP0003329_amyloid_beta_deposits1.55592477
55MP0000372_irregular_coat_pigmentation1.55196319
56MP0004858_abnormal_nervous_system1.51931508
57MP0000778_abnormal_nervous_system1.51605559
58MP0000955_abnormal_spinal_cord1.49019351
59MP0004885_abnormal_endolymph1.43276735
60MP0002066_abnormal_motor_capabilities/c1.43166012
61MP0003890_abnormal_embryonic-extraembry1.41889700
62MP0001986_abnormal_taste_sensitivity1.39035051
63MP0000427_abnormal_hair_cycle1.38145923
64MP0002163_abnormal_gland_morphology1.37124984
65MP0003011_delayed_dark_adaptation1.36313643
66MP0001905_abnormal_dopamine_level1.35733794
67MP0003633_abnormal_nervous_system1.34851152
68MP0002882_abnormal_neuron_morphology1.34771118
69MP0002928_abnormal_bile_duct1.34135186
70MP0001502_abnormal_circadian_rhythm1.28022698
71MP0005084_abnormal_gallbladder_morpholo1.21496746
72MP0005195_abnormal_posterior_eye1.19372213
73MP0001293_anophthalmia1.19329474
74MP0008058_abnormal_DNA_repair1.19009213
75MP0001188_hyperpigmentation1.16775616
76MP0000026_abnormal_inner_ear1.16611224
77MP0005379_endocrine/exocrine_gland_phen1.14536276
78MP0003631_nervous_system_phenotype1.12386313
79MP0008872_abnormal_physiological_respon1.12281894
80MP0002160_abnormal_reproductive_system1.09911273
81MP0003718_maternal_effect1.08043701
82MP0002751_abnormal_autonomic_nervous1.06827561
83MP0003690_abnormal_glial_cell1.04674845
84MP0002229_neurodegeneration1.03752394
85MP0002277_abnormal_respiratory_mucosa1.03175550
86MP0000566_synostosis1.02644937
87MP0005174_abnormal_tail_pigmentation1.02429912
88MP0002152_abnormal_brain_morphology1.00790148
89MP0005389_reproductive_system_phenotype1.00102053
90MP0000383_abnormal_hair_follicle0.99052256
91MP0004742_abnormal_vestibular_system0.97776827
92MP0003698_abnormal_male_reproductive0.97720364
93MP0001177_atelectasis0.97186162
94MP0000751_myopathy0.96473340
95MP0005551_abnormal_eye_electrophysiolog0.95968954
96MP0008874_decreased_physiological_sensi0.95532567
97MP0000569_abnormal_digit_pigmentation0.95440670
98MP0002069_abnormal_eating/drinking_beha0.93885747
99MP0003283_abnormal_digestive_organ0.92914648
100MP0001929_abnormal_gametogenesis0.92582790
101MP0000013_abnormal_adipose_tissue0.92414833
102MP0002234_abnormal_pharynx_morphology0.90978746
103MP0004145_abnormal_muscle_electrophysio0.90781180
104MP0005410_abnormal_fertilization0.88979511
105MP0001324_abnormal_eye_pigmentation0.88702234
106MP0003937_abnormal_limbs/digits/tail_de0.87333299
107MP0005535_abnormal_body_temperature0.86578934
108MP0010386_abnormal_urinary_bladder0.86351399
109MP0003119_abnormal_digestive_system0.84821011
110MP0005394_taste/olfaction_phenotype0.84611471
111MP0005499_abnormal_olfactory_system0.84611471
112MP0003634_abnormal_glial_cell0.84423831
113MP0000920_abnormal_myelination0.83935686
114MP0005391_vision/eye_phenotype0.83369728
115MP0001963_abnormal_hearing_physiology0.82304039
116MP0002210_abnormal_sex_determination0.81593675
117MP0001919_abnormal_reproductive_system0.81048351
118MP0004085_abnormal_heartbeat0.79453444
119MP0003632_abnormal_nervous_system0.78814850
120MP0004147_increased_porphyrin_level0.78439643
121MP0001485_abnormal_pinna_reflex0.77203804
122MP0008961_abnormal_basal_metabolism0.76833713
123MP0000631_abnormal_neuroendocrine_gland0.75578671
124MP0002638_abnormal_pupillary_reflex0.73710604
125MP0003075_altered_response_to0.73264299
126MP0002752_abnormal_somatic_nervous0.71509158
127MP0005167_abnormal_blood-brain_barrier0.70928990
128MP0001664_abnormal_digestion0.65787967
129MP0003123_paternal_imprinting0.65503458
130MP0004043_abnormal_pH_regulation0.64006569
131MP0003172_abnormal_lysosome_physiology0.63671249
132MP0002090_abnormal_vision0.63337720
133MP0004215_abnormal_myocardial_fiber0.62738046
134MP0005409_darkened_coat_color0.62166346
135MP0000604_amyloidosis0.61937893
136MP0005623_abnormal_meninges_morphology0.60946729
137MP0002876_abnormal_thyroid_physiology0.60567091
138MP0003121_genomic_imprinting0.59638580
139MP0003137_abnormal_impulse_conducting0.58512932
140MP0001299_abnormal_eye_distance/0.58086086
141MP0002837_dystrophic_cardiac_calcinosis0.58051095
142MP0001943_abnormal_respiration0.56876497
143MP0004233_abnormal_muscle_weight0.53181349
144MP0010769_abnormal_survival0.52643917
145MP0003646_muscle_fatigue0.52526705
146MP0004484_altered_response_of0.52194335

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.18176271
2Myokymia (HP:0002411)6.78913038
3Focal seizures (HP:0007359)5.95584248
4Visual hallucinations (HP:0002367)5.35505909
5Febrile seizures (HP:0002373)4.80004872
6Atonic seizures (HP:0010819)4.77868353
7Pancreatic cysts (HP:0001737)4.72785412
8Epileptic encephalopathy (HP:0200134)4.66033049
9Pancreatic fibrosis (HP:0100732)4.58948614
10Progressive cerebellar ataxia (HP:0002073)4.52931775
11True hermaphroditism (HP:0010459)4.51917568
12Abnormality of midbrain morphology (HP:0002418)4.44428048
13Molar tooth sign on MRI (HP:0002419)4.44428048
14Absence seizures (HP:0002121)4.36596497
15Generalized tonic-clonic seizures (HP:0002069)4.16281056
16Abnormal respiratory epithelium morphology (HP:0012253)4.09324396
17Abnormal respiratory motile cilium morphology (HP:0005938)4.09324396
18Nephronophthisis (HP:0000090)3.98491908
19Dialeptic seizures (HP:0011146)3.94772470
20Action tremor (HP:0002345)3.94278697
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.84540894
22Supranuclear gaze palsy (HP:0000605)3.80927677
23Abnormal respiratory motile cilium physiology (HP:0012261)3.79561729
24Ankle clonus (HP:0011448)3.62712824
25Broad-based gait (HP:0002136)3.49605880
26Chronic hepatic failure (HP:0100626)3.39959532
27Abnormality of the renal medulla (HP:0100957)3.38094461
28Gaze-evoked nystagmus (HP:0000640)3.36932009
29Postural instability (HP:0002172)3.35948905
30Depression (HP:0000716)3.32641727
31Abnormal eating behavior (HP:0100738)3.31718796
32Poor eye contact (HP:0000817)3.31617291
33Dysdiadochokinesis (HP:0002075)3.28879530
34Impaired vibration sensation in the lower limbs (HP:0002166)3.27215805
35Medial flaring of the eyebrow (HP:0010747)3.24542972
36Rhinitis (HP:0012384)3.24340020
37Cystic liver disease (HP:0006706)3.23854132
38Anxiety (HP:0000739)3.20199965
39Papilledema (HP:0001085)3.17451156
40Truncal ataxia (HP:0002078)3.16618829
41Progressive inability to walk (HP:0002505)3.14822607
42Urinary bladder sphincter dysfunction (HP:0002839)3.14289084
43Congenital stationary night blindness (HP:0007642)3.10148594
44Mutism (HP:0002300)3.08465140
45Dysmetria (HP:0001310)3.07894960
46Abnormal social behavior (HP:0012433)3.07388304
47Impaired social interactions (HP:0000735)3.07388304
48Hyperventilation (HP:0002883)2.91928124
49Abnormality of the renal cortex (HP:0011035)2.85842994
50Scanning speech (HP:0002168)2.78877245
51Sclerocornea (HP:0000647)2.76391340
52Pheochromocytoma (HP:0002666)2.72973305
53Limb dystonia (HP:0002451)2.71966696
54Abnormal drinking behavior (HP:0030082)2.71816875
55Polydipsia (HP:0001959)2.71816875
56Urinary urgency (HP:0000012)2.68367508
57Torticollis (HP:0000473)2.68166774
58Hemiplegia (HP:0002301)2.67810943
59Genetic anticipation (HP:0003743)2.65800431
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.64737791
61Bradykinesia (HP:0002067)2.62486334
62Congenital primary aphakia (HP:0007707)2.61362383
63Impaired smooth pursuit (HP:0007772)2.60663916
64Spastic gait (HP:0002064)2.60045427
65Ventricular fibrillation (HP:0001663)2.59700531
66Tubular atrophy (HP:0000092)2.58368453
67Amblyopia (HP:0000646)2.53376031
68Occipital encephalocele (HP:0002085)2.52257797
69Excessive salivation (HP:0003781)2.52141333
70Drooling (HP:0002307)2.52141333
71Type II lissencephaly (HP:0007260)2.52109370
72Hemiparesis (HP:0001269)2.51987593
73Abnormality of the labia minora (HP:0012880)2.51240275
74Abnormality of binocular vision (HP:0011514)2.48332231
75Diplopia (HP:0000651)2.48332231
76Fetal akinesia sequence (HP:0001989)2.48130667
77Intention tremor (HP:0002080)2.47382653
78Anencephaly (HP:0002323)2.47224922
79Status epilepticus (HP:0002133)2.44790025
80Focal dystonia (HP:0004373)2.41721179
81Polyphagia (HP:0002591)2.39576737
82Nephrogenic diabetes insipidus (HP:0009806)2.37914840
83Neuroendocrine neoplasm (HP:0100634)2.36774762
84Abolished electroretinogram (ERG) (HP:0000550)2.35510589
85Abnormality of ocular smooth pursuit (HP:0000617)2.35292590
86Bile duct proliferation (HP:0001408)2.34259531
87Abnormal biliary tract physiology (HP:0012439)2.34259531
88Postaxial foot polydactyly (HP:0001830)2.32108447
89Chronic bronchitis (HP:0004469)2.30702658
90Congenital hepatic fibrosis (HP:0002612)2.30027987
91Abnormal rod and cone electroretinograms (HP:0008323)2.28583269
92Abnormality of the lower motor neuron (HP:0002366)2.28275264
93Agitation (HP:0000713)2.27786230
94Bronchiectasis (HP:0002110)2.27630053
95Furrowed tongue (HP:0000221)2.26223847
96Attenuation of retinal blood vessels (HP:0007843)2.25978257
97Epileptiform EEG discharges (HP:0011182)2.25166387
98Polyuria (HP:0000103)2.24538412
99Neurofibrillary tangles (HP:0002185)2.24393544
100Lower limb muscle weakness (HP:0007340)2.22061955
101Genital tract atresia (HP:0001827)2.21854211
102Male pseudohermaphroditism (HP:0000037)2.21664517
103Dysmetric saccades (HP:0000641)2.21503958
104Inability to walk (HP:0002540)2.21147747
105Craniofacial dystonia (HP:0012179)2.21081980
106EEG with generalized epileptiform discharges (HP:0011198)2.19461201
107Stereotypic behavior (HP:0000733)2.19153081
108Absent speech (HP:0001344)2.17468633
109Pendular nystagmus (HP:0012043)2.16239242
110Acute necrotizing encephalopathy (HP:0006965)2.15730772
111Impaired vibratory sensation (HP:0002495)2.14536484
112Vaginal atresia (HP:0000148)2.13843632
113Blue irides (HP:0000635)2.11423259
114Dynein arm defect of respiratory motile cilia (HP:0012255)2.11343051
115Absent/shortened dynein arms (HP:0200106)2.11343051
116Generalized myoclonic seizures (HP:0002123)2.10663283
117Failure to thrive in infancy (HP:0001531)2.10509886
118Abnormality of saccadic eye movements (HP:0000570)2.09711453
119Abnormality of the corticospinal tract (HP:0002492)2.09010654
120Hypsarrhythmia (HP:0002521)2.08727766
121Optic nerve hypoplasia (HP:0000609)2.08123364
122Large for gestational age (HP:0001520)2.05758681
123Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05271167
124Cerebral inclusion bodies (HP:0100314)2.05190321
125Insidious onset (HP:0003587)2.04687840
126Termporal pattern (HP:0011008)2.04687840
127Postaxial hand polydactyly (HP:0001162)2.04580581
128Psychosis (HP:0000709)2.00792143
129Neuronal loss in central nervous system (HP:0002529)2.00455403
130Clonus (HP:0002169)1.98043959
131Progressive macrocephaly (HP:0004481)1.97957654
132Preaxial hand polydactyly (HP:0001177)1.97217553
133Megalencephaly (HP:0001355)1.97163807
134Abnormal EKG (HP:0003115)1.96602836
135Decreased central vision (HP:0007663)1.95162169
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94741128
137Gait ataxia (HP:0002066)1.93956030
138Mitochondrial inheritance (HP:0001427)1.93897485
139Insomnia (HP:0100785)1.93283851
140Rigidity (HP:0002063)1.92576031
141Incomplete penetrance (HP:0003829)1.92135193
142Acute encephalopathy (HP:0006846)1.91834088
143Resting tremor (HP:0002322)1.91682798
144Colon cancer (HP:0003003)1.90592217
145Abnormal ciliary motility (HP:0012262)1.89678681
146Septo-optic dysplasia (HP:0100842)1.89576155
147Lissencephaly (HP:0001339)1.89556701
148Increased CSF lactate (HP:0002490)1.89448664
149Hypomagnesemia (HP:0002917)1.89004408
150Intestinal atresia (HP:0011100)1.87922710
151Hypoventilation (HP:0002791)1.87795616
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87122816
153Specific learning disability (HP:0001328)1.85649808
154Annular pancreas (HP:0001734)1.85068361
155Gait imbalance (HP:0002141)1.84671038
156Poor coordination (HP:0002370)1.84501255
157Pointed chin (HP:0000307)1.81868824
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.79902377
159Peripheral hypomyelination (HP:0007182)1.79502046
160Narrow forehead (HP:0000341)1.79253373
161Oculomotor apraxia (HP:0000657)1.78056097
162Neoplasm of the peripheral nervous system (HP:0100007)1.77853121
163Optic disc pallor (HP:0000543)1.76181669
164Congenital, generalized hypertrichosis (HP:0004540)1.75040315
165Postural tremor (HP:0002174)1.74889594
1663-Methylglutaconic aciduria (HP:0003535)1.73099991
167Renal cortical cysts (HP:0000803)1.73099486
168Abnormal urine output (HP:0012590)1.72999393
169Supernumerary spleens (HP:0009799)1.72526328
170Lower limb amyotrophy (HP:0007210)1.71840378
171Abnormal mitochondria in muscle tissue (HP:0008316)1.71807632
172Oligodactyly (hands) (HP:0001180)1.71717857
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.71390710
174Methylmalonic acidemia (HP:0002912)1.69632360
175Bony spicule pigmentary retinopathy (HP:0007737)1.69430927
176Rib fusion (HP:0000902)1.69345105
177Hypothermia (HP:0002045)1.68755403
178Patellar aplasia (HP:0006443)1.68058922
179Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66900449
180Abnormality of alanine metabolism (HP:0010916)1.66900449
181Hyperalaninemia (HP:0003348)1.66900449
182Aganglionic megacolon (HP:0002251)1.66716481
183Anophthalmia (HP:0000528)1.66599626
184Gastrointestinal atresia (HP:0002589)1.66546064
185Increased corneal curvature (HP:0100692)1.66171164
186Keratoconus (HP:0000563)1.66171164
187Stomach cancer (HP:0012126)1.66038319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.07322291
2NTRK34.74100425
3MAP3K93.77150489
4EPHA43.76959231
5MAP3K43.25227314
6BMPR1B3.03791213
7MAP2K72.81965153
8MAP3K122.79111901
9MINK12.69491513
10MARK12.64986111
11TRIM282.61087091
12MAP4K22.50130881
13ZAK2.37353495
14NTRK22.35493355
15NUAK12.24838258
16WNK42.19533054
17MAP2K42.17031808
18DAPK22.12844453
19PAK62.12281248
20GRK12.10317562
21TLK12.08923793
22INSRR2.01634903
23NTRK11.93838448
24MAPK151.89448090
25CAMKK11.82582678
26CASK1.81898746
27TNIK1.79428056
28PRKD31.77596616
29RIPK41.77407231
30KSR21.74871585
31MKNK21.68430065
32ACVR1B1.67683652
33STK381.60905648
34PNCK1.53457210
35CDK51.53160458
36SIK21.50305729
37CDK191.48684007
38GRK51.45843764
39DYRK21.38350796
40FES1.36399465
41ARAF1.35786904
42MAPK131.34432107
43STK38L1.34129860
44PLK21.32516092
45DAPK11.29806180
46PRKCG1.24216913
47UHMK11.24136851
48BCR1.23393531
49KSR11.22170364
50STK391.18472880
51MAP3K131.18161732
52PRPF4B1.17573082
53CAMKK21.16681001
54TNK21.14815641
55TGFBR11.13262653
56SGK4941.12076255
57SGK2231.12076255
58FGFR21.11911601
59SGK21.05175791
60PRKCH0.99810652
61PINK10.99395627
62MAP3K20.99364908
63CAMK2A0.98830162
64LATS20.96648787
65VRK10.96172192
66MKNK10.95709527
67CAMK10.95502150
68PHKG20.94577198
69PHKG10.94577198
70MST40.94234638
71TYRO30.94065966
72PLK30.92210297
73LMTK20.91472610
74TSSK60.90361651
75TAOK30.89685741
76ADRBK10.89523587
77SGK30.89300443
78OXSR10.87794831
79STK110.87139525
80BCKDK0.86980733
81CSNK1G10.86672574
82CDK180.84022262
83WNK10.82853440
84CDK150.82124032
85ALK0.79193112
86WEE10.78729689
87CDK140.78669701
88RET0.78088108
89TIE10.77655720
90CAMK2B0.75476098
91VRK20.74786077
92SIK30.74209727
93MAP2K60.74077601
94TAOK10.73588784
95TXK0.72250965
96PAK30.71430533
97SGK10.71272406
98CDK11A0.70841223
99CSNK1G30.70095443
100BMPR20.68191914
101PLK40.67658158
102CSNK1G20.67488884
103BRSK20.66825839
104CDC42BPA0.66472835
105ERBB30.66199201
106PRKCI0.66131877
107MAPKAPK30.65896994
108NEK60.64612151
109MAP3K10.64357153
110CSNK1A1L0.62849592
111DYRK30.61514632
112STK30.60883208
113NLK0.60752535
114NME10.60263554
115PLK10.59732590
116STK160.59222609
117DYRK1A0.58507864
118PDK10.58019290
119MARK20.57084128
120CAMK2G0.56526904
121CAMK1G0.56221550
122EIF2AK30.55995772
123GRK70.54114721
124RAF10.53402890
125PDPK10.53098683
126RPS6KA30.52898037
127CAMK2D0.52359932
128FLT30.52250513
129WNK30.50969492
130PRKCE0.50452495
131MAPK100.50265464
132MAPKAPK50.48306140
133TAF10.48220378
134EPHA30.46477658
135CDC70.46471860
136BRSK10.44106514
137PRKCZ0.43863203
138AKT30.43543963
139SCYL20.43185123
140FER0.43110626
141NEK20.42679943
142CSNK1A10.42552116
143CAMK40.42386618
144PTK2B0.42149318
145FYN0.41835283
146PRKCQ0.41553544
147NEK10.40776155
148MUSK0.39508322
149IRAK10.39403176
150ADRBK20.39085219
151PKN10.37672973
152TEC0.36617548
153RPS6KA50.36405140
154ATR0.36377427
155PIK3CA0.35957727
156CSNK1D0.35320535
157PRKCB0.35004816
158ROCK20.34236359
159PRKG10.33091008
160RPS6KA20.31047214
161PRKCA0.30511561
162CDK30.29316143
163PRKACA0.29292278
164PASK0.28977533
165CHEK20.28900104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03461477
2Synaptic vesicle cycle_Homo sapiens_hsa047213.66039205
3GABAergic synapse_Homo sapiens_hsa047272.98752880
4Olfactory transduction_Homo sapiens_hsa047402.86068953
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71644849
6Circadian entrainment_Homo sapiens_hsa047132.64819819
7Morphine addiction_Homo sapiens_hsa050322.63166547
8Glutamatergic synapse_Homo sapiens_hsa047242.54359998
9Protein export_Homo sapiens_hsa030602.51001484
10Long-term potentiation_Homo sapiens_hsa047202.46811424
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45560817
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43018660
13Amphetamine addiction_Homo sapiens_hsa050312.41616484
14Linoleic acid metabolism_Homo sapiens_hsa005912.23335360
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22125637
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16775976
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15555097
18Dopaminergic synapse_Homo sapiens_hsa047282.14327273
19Salivary secretion_Homo sapiens_hsa049702.13247618
20Butanoate metabolism_Homo sapiens_hsa006502.08584401
21Maturity onset diabetes of the young_Homo sapiens_hsa049502.07874286
22Insulin secretion_Homo sapiens_hsa049112.05831260
23Parkinsons disease_Homo sapiens_hsa050122.05159874
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99353141
25Taste transduction_Homo sapiens_hsa047421.91664670
26Gastric acid secretion_Homo sapiens_hsa049711.89457032
27Basal transcription factors_Homo sapiens_hsa030221.88049043
28Cholinergic synapse_Homo sapiens_hsa047251.84938933
29Cocaine addiction_Homo sapiens_hsa050301.84454177
30Selenocompound metabolism_Homo sapiens_hsa004501.82480195
31Homologous recombination_Homo sapiens_hsa034401.82211050
32Huntingtons disease_Homo sapiens_hsa050161.77504234
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73106200
34Serotonergic synapse_Homo sapiens_hsa047261.72691213
35Fanconi anemia pathway_Homo sapiens_hsa034601.71760096
36Collecting duct acid secretion_Homo sapiens_hsa049661.69517729
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66306750
38Renin secretion_Homo sapiens_hsa049241.66261227
39Long-term depression_Homo sapiens_hsa047301.64667232
40RNA polymerase_Homo sapiens_hsa030201.62106667
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59239021
42Calcium signaling pathway_Homo sapiens_hsa040201.58707998
43Ether lipid metabolism_Homo sapiens_hsa005651.52659165
44Oxytocin signaling pathway_Homo sapiens_hsa049211.51887000
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44777320
46Tryptophan metabolism_Homo sapiens_hsa003801.43692590
47Propanoate metabolism_Homo sapiens_hsa006401.40307073
48GnRH signaling pathway_Homo sapiens_hsa049121.37449611
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36900081
50Caffeine metabolism_Homo sapiens_hsa002321.29688559
51Gap junction_Homo sapiens_hsa045401.28057484
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28053150
53cAMP signaling pathway_Homo sapiens_hsa040241.25493912
54Nitrogen metabolism_Homo sapiens_hsa009101.25360463
55RNA degradation_Homo sapiens_hsa030181.25303543
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24482713
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23586789
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21772170
59Chemical carcinogenesis_Homo sapiens_hsa052041.20393110
60Type II diabetes mellitus_Homo sapiens_hsa049301.19418365
61Peroxisome_Homo sapiens_hsa041461.17379044
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16161665
63Non-homologous end-joining_Homo sapiens_hsa034501.15217355
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13263015
65Primary bile acid biosynthesis_Homo sapiens_hsa001201.09096474
66Vibrio cholerae infection_Homo sapiens_hsa051101.08345903
67Estrogen signaling pathway_Homo sapiens_hsa049151.08107752
68Regulation of autophagy_Homo sapiens_hsa041401.07564018
69Retinol metabolism_Homo sapiens_hsa008301.07014415
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05665690
71Cardiac muscle contraction_Homo sapiens_hsa042601.05274331
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03307843
73Steroid hormone biosynthesis_Homo sapiens_hsa001401.00514254
74Proteasome_Homo sapiens_hsa030500.99879810
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96711657
76ErbB signaling pathway_Homo sapiens_hsa040120.93785292
77Glioma_Homo sapiens_hsa052140.92506464
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92151433
79Axon guidance_Homo sapiens_hsa043600.91874607
80Melanogenesis_Homo sapiens_hsa049160.91457480
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90581523
82Phototransduction_Homo sapiens_hsa047440.88772431
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88001826
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86791496
85Dorso-ventral axis formation_Homo sapiens_hsa043200.86186527
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.84707301
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83966737
88ABC transporters_Homo sapiens_hsa020100.83199487
89Arachidonic acid metabolism_Homo sapiens_hsa005900.82665139
90Pancreatic secretion_Homo sapiens_hsa049720.81652830
91Steroid biosynthesis_Homo sapiens_hsa001000.80987565
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.78597936
93Thyroid hormone synthesis_Homo sapiens_hsa049180.78317113
94Oocyte meiosis_Homo sapiens_hsa041140.77941571
95Type I diabetes mellitus_Homo sapiens_hsa049400.77764282
96Purine metabolism_Homo sapiens_hsa002300.76937455
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.76547119
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.73981616
99Hedgehog signaling pathway_Homo sapiens_hsa043400.72494887
100Histidine metabolism_Homo sapiens_hsa003400.72056117
101Sulfur metabolism_Homo sapiens_hsa009200.70754095
102Dilated cardiomyopathy_Homo sapiens_hsa054140.69620293
103beta-Alanine metabolism_Homo sapiens_hsa004100.69336138
104MAPK signaling pathway_Homo sapiens_hsa040100.69006703
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68922895
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68298603
107One carbon pool by folate_Homo sapiens_hsa006700.68281546
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67557019
109Metabolic pathways_Homo sapiens_hsa011000.67198479
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65573572
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63311667
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62873064
113Basal cell carcinoma_Homo sapiens_hsa052170.62101592
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60433318
115Choline metabolism in cancer_Homo sapiens_hsa052310.59025178
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58237802
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55842533
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55022021
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.54278119
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52617942
121Inositol phosphate metabolism_Homo sapiens_hsa005620.52090639
122Alcoholism_Homo sapiens_hsa050340.51972554
123Ras signaling pathway_Homo sapiens_hsa040140.51666853
124Bile secretion_Homo sapiens_hsa049760.50824233
125Glucagon signaling pathway_Homo sapiens_hsa049220.48484697
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47988747
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47702887
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47610851
129Pyrimidine metabolism_Homo sapiens_hsa002400.47122895
130Glycerolipid metabolism_Homo sapiens_hsa005610.47064820
131Mismatch repair_Homo sapiens_hsa034300.46872087
132Nucleotide excision repair_Homo sapiens_hsa034200.46189240
133Rap1 signaling pathway_Homo sapiens_hsa040150.45634860
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45131222
135Ovarian steroidogenesis_Homo sapiens_hsa049130.44332037
136Endocytosis_Homo sapiens_hsa041440.42977468
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.42575766
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42521557
139Alzheimers disease_Homo sapiens_hsa050100.40998965
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40407542
141Circadian rhythm_Homo sapiens_hsa047100.39744037
142Prion diseases_Homo sapiens_hsa050200.39566669
143Ribosome_Homo sapiens_hsa030100.38522718
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37400002
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35463587
146Fatty acid degradation_Homo sapiens_hsa000710.35129377
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34799940
148Insulin signaling pathway_Homo sapiens_hsa049100.34599448
149VEGF signaling pathway_Homo sapiens_hsa043700.33568203
150RNA transport_Homo sapiens_hsa030130.33318614
151mTOR signaling pathway_Homo sapiens_hsa041500.33028633
152Fat digestion and absorption_Homo sapiens_hsa049750.32812100
153Glutathione metabolism_Homo sapiens_hsa004800.32454824
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.31517626
155Mineral absorption_Homo sapiens_hsa049780.31419282
156Wnt signaling pathway_Homo sapiens_hsa043100.31181798
157Oxidative phosphorylation_Homo sapiens_hsa001900.30732383
158Hippo signaling pathway_Homo sapiens_hsa043900.30584431
159African trypanosomiasis_Homo sapiens_hsa051430.30403283
160Chemokine signaling pathway_Homo sapiens_hsa040620.30296895
161Rheumatoid arthritis_Homo sapiens_hsa053230.30099234
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29548924
163Renal cell carcinoma_Homo sapiens_hsa052110.28773281
164Asthma_Homo sapiens_hsa053100.28732168
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28308433
166Non-small cell lung cancer_Homo sapiens_hsa052230.28186258
167Endometrial cancer_Homo sapiens_hsa052130.26845627

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