DZIP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.04197230
2axoneme assembly (GO:0035082)8.59432813
3regulation of cilium movement (GO:0003352)7.80892342
4left/right axis specification (GO:0070986)6.93455739
5intraciliary transport (GO:0042073)6.45851885
6ventricular system development (GO:0021591)6.19194248
7primary alcohol catabolic process (GO:0034310)5.90835086
8microtubule bundle formation (GO:0001578)5.68345114
9* cilium organization (GO:0044782)5.59046286
10* cilium assembly (GO:0042384)5.43887528
11establishment of apical/basal cell polarity (GO:0035089)5.17170570
12glomerular epithelial cell development (GO:0072310)4.96833395
13centriole assembly (GO:0098534)4.94289394
14vitamin transmembrane transport (GO:0035461)4.86038954
15ethanol metabolic process (GO:0006067)4.73572949
16microtubule-based movement (GO:0007018)4.59379057
17lung epithelium development (GO:0060428)4.51564446
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.49289743
19establishment of monopolar cell polarity (GO:0061162)4.49289743
20regulation of microtubule-based movement (GO:0060632)4.43443604
21* cellular component assembly involved in morphogenesis (GO:0010927)4.40746096
22diterpenoid biosynthetic process (GO:0016102)4.25696734
23protein localization to cilium (GO:0061512)4.22414910
24sperm capacitation (GO:0048240)4.19451346
25microtubule depolymerization (GO:0007019)4.14069389
26cilium morphogenesis (GO:0060271)4.11775652
27lateral ventricle development (GO:0021670)4.03550044
28response to xenobiotic stimulus (GO:0009410)4.01861456
29positive regulation of smoothened signaling pathway (GO:0045880)4.01350566
30pyrimidine-containing compound transmembrane transport (GO:0072531)4.01091102
31microtubule polymerization or depolymerization (GO:0031109)3.93793229
32* cell projection assembly (GO:0030031)3.83916131
33paraxial mesoderm development (GO:0048339)3.78392023
34chondrocyte proliferation (GO:0035988)3.70639077
35sequestering of extracellular ligand from receptor (GO:0035581)3.69995094
36response to pheromone (GO:0019236)3.60824054
37one-carbon compound transport (GO:0019755)3.59357219
38negative regulation of inclusion body assembly (GO:0090084)3.52960496
39negative regulation of T cell differentiation in thymus (GO:0033085)3.52275125
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.46169169
41axon extension involved in axon guidance (GO:0048846)3.46169169
42centriole replication (GO:0007099)3.42400533
43ethanol oxidation (GO:0006069)3.37789960
44mesenchymal-epithelial cell signaling (GO:0060638)3.35211682
45determination of left/right symmetry (GO:0007368)3.29583094
46terpenoid biosynthetic process (GO:0016114)3.27980831
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.26089175
48lateral sprouting from an epithelium (GO:0060601)3.25235729
49regulation of interleukin-5 production (GO:0032674)3.25001128
50sperm motility (GO:0030317)3.24826790
51cerebral cortex radially oriented cell migration (GO:0021799)3.23333299
52cytoplasmic microtubule organization (GO:0031122)3.22804702
53determination of bilateral symmetry (GO:0009855)3.17422594
54retinoic acid metabolic process (GO:0042573)3.15469260
55negative regulation of humoral immune response (GO:0002921)3.11708477
56specification of symmetry (GO:0009799)3.11579195
57retinal rod cell development (GO:0046548)3.10949065
58smoothened signaling pathway (GO:0007224)3.05834204
59aldehyde catabolic process (GO:0046185)3.05306568
60cell proliferation in forebrain (GO:0021846)3.04337512
61intra-S DNA damage checkpoint (GO:0031573)2.98408057
62nucleoside diphosphate phosphorylation (GO:0006165)2.96700065
63embryonic camera-type eye development (GO:0031076)2.95051759
64apical protein localization (GO:0045176)2.94362808
65limb bud formation (GO:0060174)2.93934265
66heart looping (GO:0001947)2.91647003
67bone trabecula formation (GO:0060346)2.87968115
68microtubule-based process (GO:0007017)2.87749485
69embryonic heart tube morphogenesis (GO:0003143)2.85988973
70collagen fibril organization (GO:0030199)2.80259444
71regulation of synapse maturation (GO:0090128)2.79385660
72neuroblast proliferation (GO:0007405)2.78965686
73regulation of smoothened signaling pathway (GO:0008589)2.78939179
74sensory perception of smell (GO:0007608)2.78618262
75axonal fasciculation (GO:0007413)2.76839717
76dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75400203
77establishment or maintenance of bipolar cell polarity (GO:0061245)2.74031854
78establishment or maintenance of apical/basal cell polarity (GO:0035088)2.74031854
79extracellular negative regulation of signal transduction (GO:1900116)2.71588386
80extracellular regulation of signal transduction (GO:1900115)2.71588386
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.70212993
82lung-associated mesenchyme development (GO:0060484)2.69559012
83negative regulation of astrocyte differentiation (GO:0048712)2.68697532
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68299077
85nephron tubule morphogenesis (GO:0072078)2.68016700
86nephron epithelium morphogenesis (GO:0072088)2.68016700
87O-glycan processing (GO:0016266)2.67962036
88regulation of axon extension involved in axon guidance (GO:0048841)2.67550181
89* organelle assembly (GO:0070925)2.65490505
90regulation of interleukin-13 production (GO:0032656)2.64476148
91energy homeostasis (GO:0097009)2.63829166
92negative regulation of B cell mediated immunity (GO:0002713)2.63631367
93negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63631367
94regulation of microtubule depolymerization (GO:0031114)2.63606717
95regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.63370865
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60768950
97establishment of tissue polarity (GO:0007164)2.59752862
98establishment of planar polarity (GO:0001736)2.59752862
99retinol metabolic process (GO:0042572)2.58678942
100regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.58463020
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.58008923
102regulation of axon guidance (GO:1902667)2.57270322
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55935531
104dermatan sulfate biosynthetic process (GO:0030208)2.55766937
105kidney mesenchyme development (GO:0072074)2.54180338
106branching involved in salivary gland morphogenesis (GO:0060445)2.53511756
107negative regulation of axon extension involved in axon guidance (GO:0048843)2.53096076
108central nervous system projection neuron axonogenesis (GO:0021952)2.51042370
109outer ear morphogenesis (GO:0042473)2.51032849
110vocalization behavior (GO:0071625)2.49833925
111nephron tubule development (GO:0072080)2.49210173
112nonmotile primary cilium assembly (GO:0035058)2.49073416
113regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48598853
114negative regulation of chondrocyte differentiation (GO:0032331)2.48543965
115primary alcohol metabolic process (GO:0034308)2.47536438
116detection of calcium ion (GO:0005513)2.46939922
117neural crest cell development (GO:0014032)2.46623832
118craniofacial suture morphogenesis (GO:0097094)2.45660610
119tolerance induction (GO:0002507)2.45124252
120negative regulation of catenin import into nucleus (GO:0035414)2.43731088
121ganglion development (GO:0061548)2.40118792
122negative regulation of axon guidance (GO:1902668)2.39837039
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38743094
124limb development (GO:0060173)2.38427921
125appendage development (GO:0048736)2.38427921
126hippo signaling (GO:0035329)2.38383703
127glutathione derivative biosynthetic process (GO:1901687)2.38130947
128glutathione derivative metabolic process (GO:1901685)2.38130947
129metanephric mesenchyme development (GO:0072075)2.36699125
130photoreceptor cell maintenance (GO:0045494)2.36697054
131embryonic heart tube development (GO:0035050)2.36588393
132negative regulation of embryonic development (GO:0045992)2.36260850
133asymmetric protein localization (GO:0008105)2.36173091
134renal tubule development (GO:0061326)2.35925263
135negative chemotaxis (GO:0050919)2.35867379
136cell communication by electrical coupling (GO:0010644)2.34945685
137spermatid development (GO:0007286)2.33474131
138positive regulation of cartilage development (GO:0061036)2.33356483
139positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32836955
140protein heterotetramerization (GO:0051290)2.32080408
141positive regulation of neuroblast proliferation (GO:0002052)2.31708072
142Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29899186
143wound healing, spreading of epidermal cells (GO:0035313)2.29897513
144neuron recognition (GO:0008038)2.29235621
145renal tubule morphogenesis (GO:0061333)2.28973088
146dermatan sulfate metabolic process (GO:0030205)2.28918217
147excretion (GO:0007588)2.28108029
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.27793012
149hydrogen peroxide catabolic process (GO:0042744)2.26936151
150notochord development (GO:0030903)2.26316354
151negative regulation of microtubule depolymerization (GO:0007026)2.26228485
152regulation of mesenchymal cell proliferation (GO:0010464)2.25549956
153ovulation cycle (GO:0042698)2.25528417
154atrial cardiac muscle cell action potential (GO:0086014)2.25126534
155positive regulation of meiosis (GO:0045836)2.24473950
156adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.23800329
157positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.23270436
158ionotropic glutamate receptor signaling pathway (GO:0035235)2.23195037
159nephron epithelium development (GO:0072009)2.22261840
160transmission of nerve impulse (GO:0019226)2.22140608
161microtubule severing (GO:0051013)2.21764942
162embryonic body morphogenesis (GO:0010172)2.21422568
163camera-type eye morphogenesis (GO:0048593)2.21353870
164organ induction (GO:0001759)2.21300228
165mesenchymal cell differentiation (GO:0048762)2.20766940
166epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.19138692
167positive regulation of fibroblast migration (GO:0010763)2.19102270
168cell-cell signaling involved in cell fate commitment (GO:0045168)2.19097090
169forelimb morphogenesis (GO:0035136)2.19024430
170mesenchymal cell development (GO:0014031)2.18874912
171developmental induction (GO:0031128)2.18675204
172glutamate receptor signaling pathway (GO:0007215)2.18473755
173chondrocyte development (GO:0002063)2.17827834
174positive regulation of mesenchymal cell proliferation (GO:0002053)2.17663780
175mesenchyme development (GO:0060485)2.17524593
176cell proliferation involved in metanephros development (GO:0072203)2.16885248
177embryonic digit morphogenesis (GO:0042733)2.16776326
178postsynaptic membrane organization (GO:0001941)2.16755350
179embryonic skeletal joint morphogenesis (GO:0060272)2.16409115
180positive regulation of CREB transcription factor activity (GO:0032793)2.16378139
181ephrin receptor signaling pathway (GO:0048013)2.16029978
182negative regulation of hormone biosynthetic process (GO:0032353)2.15710161
183negative regulation of hormone metabolic process (GO:0032351)2.15710161
184regulation of skeletal muscle fiber development (GO:0048742)2.14922333
185positive regulation of cardiac muscle cell differentiation (GO:2000727)2.14102481
186embryonic forelimb morphogenesis (GO:0035115)2.13649243
187negative regulation of oligodendrocyte differentiation (GO:0048715)2.13377653
188axonemal dynein complex assembly (GO:0070286)19.0740841
189cilium or flagellum-dependent cell motility (GO:0001539)16.3138697
190cilium movement (GO:0003341)14.1304079
191epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.3465528
192motile cilium assembly (GO:0044458)13.1757571
193epithelial cilium movement (GO:0003351)12.1381381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.54807831
2EZH2_22144423_ChIP-Seq_EOC_Human4.10264352
3GBX2_23144817_ChIP-Seq_PC3_Human3.66124051
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.61836904
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.97240534
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.87208565
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73478908
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71494709
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.63539772
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63435877
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62299451
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62299451
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57454172
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.52072774
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49184681
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46746940
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44361446
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41955956
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.19495723
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18690492
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.11410655
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11118972
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.03083294
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98856182
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96892815
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94426565
27DROSHA_22980978_ChIP-Seq_HELA_Human1.92018359
28TP53_18474530_ChIP-ChIP_U2OS_Human1.89160667
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86264055
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.84888129
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84865877
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.84237267
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.83495848
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81406091
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.76814114
36AR_21572438_ChIP-Seq_LNCaP_Human1.76550944
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73128279
38* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70648642
39TP63_23658742_ChIP-Seq_EP156T_Human1.66458372
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66340710
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65734962
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65342626
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64063442
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62220464
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52297078
46SMAD4_21799915_ChIP-Seq_A2780_Human1.52281418
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51783835
48AHR_22903824_ChIP-Seq_MCF-7_Human1.51313855
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51230444
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51110905
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.49109887
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.49080758
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48793871
54ETV1_20927104_ChIP-Seq_GIST48_Human1.46716479
55P300_19829295_ChIP-Seq_ESCs_Human1.46562611
56PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.46518154
57PHF8_20622853_ChIP-Seq_HELA_Human1.46071789
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.44182098
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44053833
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43174584
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.42405719
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.41637097
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.40942076
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.40345676
65IGF1R_20145208_ChIP-Seq_DFB_Human1.39603684
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39411779
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.38073330
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36721845
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36500225
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36097091
71CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.35932465
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35848847
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35019023
74KLF5_25053715_ChIP-Seq_YYC3_Human1.34216178
75NFYA_21822215_ChIP-Seq_K562_Human1.31882582
76TBL1_22424771_ChIP-Seq_293T_Human1.31788051
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31449791
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.31182024
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.30836513
80TP53_16413492_ChIP-PET_HCT116_Human1.30209111
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28901667
82SMC4_20622854_ChIP-Seq_HELA_Human1.28808844
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28608004
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28059744
85TP63_22573176_ChIP-Seq_HFKS_Human1.28006845
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27202978
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.26979202
88NFYB_21822215_ChIP-Seq_K562_Human1.25989107
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25801538
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25584101
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24841773
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.24645434
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22729470
94RBPJ_21746931_ChIP-Seq_IB4_Human1.22138940
95RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21035629
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20388378
97TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20284343
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18769490
99* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18750918
100CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18522637
101STAT3_23295773_ChIP-Seq_U87_Human1.18445357
102FUS_26573619_Chip-Seq_HEK293_Human1.18432386
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17599439
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16288110
105* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16237660
106* AR_19668381_ChIP-Seq_PC3_Human1.15720787
107VDR_22108803_ChIP-Seq_LS180_Human1.15696888
108RUNX2_22187159_ChIP-Seq_PCA_Human1.15617365
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.15603310
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13464928
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12825256
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12214402
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.12036743
114AR_25329375_ChIP-Seq_VCAP_Human1.11843015
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10585035
116FOXA1_25552417_ChIP-Seq_VCAP_Human1.10277484
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10275426
118BCAT_22108803_ChIP-Seq_LS180_Human1.09820448
119CJUN_26792858_Chip-Seq_BT549_Human1.09671902
120SOX2_20726797_ChIP-Seq_SW620_Human1.09283348
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09125996
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08837884
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.08320594
124TCF4_23295773_ChIP-Seq_U87_Human1.07457163
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07219478
126EWS_26573619_Chip-Seq_HEK293_Human1.07192206
127RNF2_27304074_Chip-Seq_NSC_Mouse1.06008491
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05742052
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05702368
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.05619253
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.05437519
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05165997
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04422560
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04089066
135GATA4_25053715_ChIP-Seq_YYC3_Human1.03955586
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03891485
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03139064
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03139064
139TCF4_18268006_ChIP-ChIP_LS174T_Human1.02833846
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01262471
141SOX9_26525672_Chip-Seq_HEART_Mouse1.00735625
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99160975
143* CTCF_27219007_Chip-Seq_Bcells_Human0.99100108
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98992982
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.98274240
146STAT1_20625510_ChIP-Seq_HELA_Human0.98248532
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.98208883
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.98120209
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98014238
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97935471
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97803235
152GATA6_21074721_ChIP-Seq_CACO-2_Human0.97622229
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.97223106
154FOXA2_19822575_ChIP-Seq_HepG2_Human0.97168640
155* JUN_21703547_ChIP-Seq_K562_Human0.96995170
156STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96890620
157TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96692999
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94417624
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93270127
160BRD4_25478319_ChIP-Seq_HGPS_Human0.93252879
161TP53_22127205_ChIP-Seq_IMR90_Human0.92890213
162TCF4_22108803_ChIP-Seq_LS180_Human0.91851947
163GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91646652
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91337516
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91337516
166RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91202022
167PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.90883793
168KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90083566
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87947178
170CDX2_20551321_ChIP-Seq_CACO-2_Human0.85461726
171CBP_20019798_ChIP-Seq_JUKART_Human0.84789972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.27101253
2MP0002132_abnormal_respiratory_system4.07842031
3MP0008875_abnormal_xenobiotic_pharmacok3.86735932
4MP0005503_abnormal_tendon_morphology3.60542882
5MP0008438_abnormal_cutaneous_collagen2.95761839
6MP0005623_abnormal_meninges_morphology2.72849944
7MP0004859_abnormal_synaptic_plasticity2.69431740
8MP0010030_abnormal_orbit_morphology2.27433272
9MP0002277_abnormal_respiratory_mucosa2.20713381
10MP0005171_absent_coat_pigmentation2.17612827
11MP0000383_abnormal_hair_follicle2.17179814
12MP0003385_abnormal_body_wall2.09038687
13MP0005275_abnormal_skin_tensile2.07684561
14MP0004043_abnormal_pH_regulation1.98953512
15MP0009250_abnormal_appendicular_skeleto1.96399195
16MP0000566_synostosis1.92035597
17MP0001984_abnormal_olfaction1.91323287
18MP0005377_hearing/vestibular/ear_phenot1.90559323
19MP0003878_abnormal_ear_physiology1.90559323
20MP0003279_aneurysm1.89884617
21MP0003941_abnormal_skin_development1.89237617
22MP0010678_abnormal_skin_adnexa1.86550978
23MP0003942_abnormal_urinary_system1.84560778
24MP0009379_abnormal_foot_pigmentation1.82256399
25MP0005257_abnormal_intraocular_pressure1.73343660
26MP0003283_abnormal_digestive_organ1.71829583
27MP0009384_cardiac_valve_regurgitation1.68987648
28MP0000049_abnormal_middle_ear1.66365569
29MP0002249_abnormal_larynx_morphology1.63046789
30MP0003937_abnormal_limbs/digits/tail_de1.62172893
31MP0003122_maternal_imprinting1.60010422
32MP0002168_other_aberrant_phenotype1.59733864
33MP0001299_abnormal_eye_distance/1.59729114
34MP0005508_abnormal_skeleton_morphology1.58058395
35MP0004272_abnormal_basement_membrane1.57754935
36MP0001958_emphysema1.57527409
37MP0003755_abnormal_palate_morphology1.55629057
38MP0000778_abnormal_nervous_system1.52991989
39MP0000762_abnormal_tongue_morphology1.49449269
40MP0003950_abnormal_plasma_membrane1.47186281
41MP0000537_abnormal_urethra_morphology1.45716492
42MP0001188_hyperpigmentation1.42671267
43MP0003635_abnormal_synaptic_transmissio1.41141870
44MP0002932_abnormal_joint_morphology1.40376104
45MP0003890_abnormal_embryonic-extraembry1.39289520
46MP0002233_abnormal_nose_morphology1.39076183
47MP0000534_abnormal_ureter_morphology1.37657557
48MP0006292_abnormal_olfactory_placode1.36895668
49MP0003787_abnormal_imprinting1.33888720
50MP0002108_abnormal_muscle_morphology1.31289450
51MP0000678_abnormal_parathyroid_gland1.31129618
52MP0001177_atelectasis1.29058855
53MP0002938_white_spotting1.28420438
54MP0004858_abnormal_nervous_system1.26701463
55MP0002116_abnormal_craniofacial_bone1.26256377
56MP0003880_abnormal_central_pattern1.24975163
57MP0005083_abnormal_biliary_tract1.23306533
58MP0000428_abnormal_craniofacial_morphol1.22742834
59MP0003121_genomic_imprinting1.22159761
60MP0002102_abnormal_ear_morphology1.21721444
61MP0002295_abnormal_pulmonary_circulatio1.21360112
62MP0004133_heterotaxia1.19323650
63MP0003935_abnormal_craniofacial_develop1.19264221
64MP0002234_abnormal_pharynx_morphology1.18598310
65MP0001849_ear_inflammation1.15706223
66MP0002282_abnormal_trachea_morphology1.14891393
67MP0004019_abnormal_vitamin_homeostasis1.14431863
68MP0003136_yellow_coat_color1.13353474
69MP0010368_abnormal_lymphatic_system1.13332331
70MP0002063_abnormal_learning/memory/cond1.12225740
71MP0004134_abnormal_chest_morphology1.11874699
72MP0008789_abnormal_olfactory_epithelium1.11128396
73MP0002084_abnormal_developmental_patter1.10258370
74MP0005646_abnormal_pituitary_gland1.09310342
75MP0009745_abnormal_behavioral_response1.09000390
76MP0009053_abnormal_anal_canal1.08869080
77MP0003115_abnormal_respiratory_system1.08783652
78MP0005408_hypopigmentation1.08572850
79MP0002896_abnormal_bone_mineralization1.07723323
80MP0002109_abnormal_limb_morphology1.07525761
81MP0003938_abnormal_ear_development1.07143570
82MP0009780_abnormal_chondrocyte_physiolo1.06761986
83MP0005023_abnormal_wound_healing1.06504128
84MP0001346_abnormal_lacrimal_gland1.06435257
85MP0002092_abnormal_eye_morphology1.05973481
86MP0002177_abnormal_outer_ear1.04672400
87MP0000432_abnormal_head_morphology1.03081841
88MP0005248_abnormal_Harderian_gland1.02220453
89MP0000163_abnormal_cartilage_morphology1.02182954
90MP0005499_abnormal_olfactory_system1.01102406
91MP0005394_taste/olfaction_phenotype1.01102406
92MP0005423_abnormal_somatic_nervous1.01046888
93MP0003566_abnormal_cell_adhesion1.00286491
94MP0000631_abnormal_neuroendocrine_gland0.99517138
95MP0001486_abnormal_startle_reflex0.99501260
96MP0005395_other_phenotype0.97947897
97MP0002184_abnormal_innervation0.96397877
98MP0002572_abnormal_emotion/affect_behav0.95840098
99MP0001485_abnormal_pinna_reflex0.93716846
100MP0002089_abnormal_postnatal_growth/wei0.93088431
101MP0002115_abnormal_skeleton_extremities0.93053752
102MP0000026_abnormal_inner_ear0.92463271
103MP0002114_abnormal_axial_skeleton0.91943483
104MP0005645_abnormal_hypothalamus_physiol0.91648473
105MP0005367_renal/urinary_system_phenotyp0.91570075
106MP0000516_abnormal_urinary_system0.91570075
107MP0003861_abnormal_nervous_system0.91465404
108MP0000013_abnormal_adipose_tissue0.91340232
109MP0002557_abnormal_social/conspecific_i0.90609623
110MP0005409_darkened_coat_color0.90441936
111MP0003119_abnormal_digestive_system0.89006046
112MP0005391_vision/eye_phenotype0.88630828
113MP0003137_abnormal_impulse_conducting0.87830652
114MP0005220_abnormal_exocrine_pancreas0.87635284
115MP0002111_abnormal_tail_morphology0.87552271
116MP0001293_anophthalmia0.86594716
117MP0002127_abnormal_cardiovascular_syste0.84932719
118MP0001968_abnormal_touch/_nociception0.84570978
119MP0003705_abnormal_hypodermis_morpholog0.84228574
120MP0003698_abnormal_male_reproductive0.84202006
121MP0002697_abnormal_eye_size0.83396793
122MP0003123_paternal_imprinting0.82843795
123MP0001929_abnormal_gametogenesis0.82204905
124MP0001286_abnormal_eye_development0.81511007
125MP0009697_abnormal_copulation0.79321875
126MP0002160_abnormal_reproductive_system0.78674755
127MP0002736_abnormal_nociception_after0.78443816
128MP0000751_myopathy0.76946082
129MP0002085_abnormal_embryonic_tissue0.75948754
130MP0003091_abnormal_cell_migration0.74791213
131MP0001765_abnormal_ion_homeostasis0.74350448
132MP0001879_abnormal_lymphatic_vessel0.72702299
133MP0005164_abnormal_response_to0.72058286
134MP0005165_increased_susceptibility_to0.71178582
135MP0001270_distended_abdomen0.70322707
136MP0002909_abnormal_adrenal_gland0.67218368
137MP0002060_abnormal_skin_morphology0.66435057
138MP0002928_abnormal_bile_duct0.66354280
139MP0000467_abnormal_esophagus_morphology0.62302342
140MP0005195_abnormal_posterior_eye0.62100307
141MP0010234_abnormal_vibrissa_follicle0.60947556

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.38014499
2Chronic bronchitis (HP:0004469)6.93253287
3Bronchiectasis (HP:0002110)6.55886846
4Nasal polyposis (HP:0100582)5.92664359
5Abnormality of the nasal mucosa (HP:0000433)4.95752059
6Infertility (HP:0000789)3.93580112
7Occipital encephalocele (HP:0002085)3.80154941
8Male infertility (HP:0003251)3.73277119
9Bronchitis (HP:0012387)3.59287939
10Shallow orbits (HP:0000586)3.42064185
11Pancreatic fibrosis (HP:0100732)3.41492960
12Recurrent sinusitis (HP:0011108)3.40829730
13Premature rupture of membranes (HP:0001788)3.36250105
14Chronic sinusitis (HP:0011109)3.24565201
15Recurrent otitis media (HP:0000403)3.23198311
16Abnormality of dentin (HP:0010299)3.21350380
17True hermaphroditism (HP:0010459)3.18454858
18Protrusio acetabuli (HP:0003179)3.01220312
19Aplasia involving bones of the extremities (HP:0009825)2.86675472
20Aplasia involving bones of the upper limbs (HP:0009823)2.86675472
21Aplasia of the phalanges of the hand (HP:0009802)2.86675472
22Neonatal short-limb short stature (HP:0008921)2.84781520
23Atelectasis (HP:0100750)2.84159619
24Cystic liver disease (HP:0006706)2.83041926
25Nephronophthisis (HP:0000090)2.82355773
26Broad metatarsal (HP:0001783)2.78658034
27Molar tooth sign on MRI (HP:0002419)2.76585420
28Abnormality of midbrain morphology (HP:0002418)2.76585420
29Pancreatic cysts (HP:0001737)2.69602381
30Mesomelia (HP:0003027)2.60694671
31Febrile seizures (HP:0002373)2.55783780
32Chronic hepatic failure (HP:0100626)2.55602240
33Postaxial foot polydactyly (HP:0001830)2.55522951
34Tubulointerstitial nephritis (HP:0001970)2.51715681
35Morphological abnormality of the middle ear (HP:0008609)2.49976657
36Atrophic scars (HP:0001075)2.43390478
37Focal motor seizures (HP:0011153)2.41507241
38Absent frontal sinuses (HP:0002688)2.34113686
39Hyperactive renin-angiotensin system (HP:0000841)2.32794635
40Cutaneous finger syndactyly (HP:0010554)2.30621752
41Bronchomalacia (HP:0002780)2.30365498
42Abnormality of the renal medulla (HP:0100957)2.24493885
43Coronal craniosynostosis (HP:0004440)2.24207923
44Aplasia/Hypoplasia of the lens (HP:0008063)2.22603151
45Congenital hepatic fibrosis (HP:0002612)2.21300751
46Cutaneous syndactyly (HP:0012725)2.17815296
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17491867
48Short 4th metacarpal (HP:0010044)2.17491867
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16030222
50Abnormality of the middle phalanges of the toes (HP:0010183)2.13342308
51Soft skin (HP:0000977)2.13002410
52Fibular aplasia (HP:0002990)2.09430427
53Anencephaly (HP:0002323)2.04544739
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.03611381
55Fragile skin (HP:0001030)2.01833160
56Focal seizures (HP:0007359)2.01048413
57Abnormal respiratory motile cilium morphology (HP:0005938)10.5089948
58Abnormal respiratory epithelium morphology (HP:0012253)10.5089948
59Absent/shortened dynein arms (HP:0200106)10.4679479
60Dynein arm defect of respiratory motile cilia (HP:0012255)10.4679479
61Chronic otitis media (HP:0000389)1.99485685
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98733230
63Short hallux (HP:0010109)1.97262741
64Preaxial foot polydactyly (HP:0001841)1.96785463
65Abnormality of the nasal septum (HP:0000419)1.95751738
66Synostosis involving the elbow (HP:0003938)1.94326727
67Humeroradial synostosis (HP:0003041)1.94326727
68Myelomeningocele (HP:0002475)1.93287101
69Aortic dissection (HP:0002647)1.93277679
70Medial flaring of the eyebrow (HP:0010747)1.91501618
71Pulmonary artery stenosis (HP:0004415)1.91363639
72Aplasia/Hypoplasia of the fibula (HP:0006492)1.90788607
73Aplasia cutis congenita (HP:0001057)1.87783179
74Short nail (HP:0001799)1.85768631
75Omphalocele (HP:0001539)1.84715786
76Bladder diverticulum (HP:0000015)1.83981068
77Septo-optic dysplasia (HP:0100842)1.83948403
78Tubular atrophy (HP:0000092)1.83368290
79Absent eyebrow (HP:0002223)1.80904843
80Midline defect of the nose (HP:0004122)1.80073623
81Bell-shaped thorax (HP:0001591)1.79535566
82Narrow nasal bridge (HP:0000446)1.79416780
83Congenital primary aphakia (HP:0007707)1.79082515
84Wrist flexion contracture (HP:0001239)1.75246824
85Abnormality of the parietal bone (HP:0002696)1.75140506
86Hypoplasia of the iris (HP:0007676)1.74602508
87Aqueductal stenosis (HP:0002410)1.73053382
88Broad toe (HP:0001837)1.72812863
89Follicular hyperkeratosis (HP:0007502)1.72208651
90Sclerocornea (HP:0000647)1.71898307
91Synostosis of carpal bones (HP:0005048)1.71554026
92Gait imbalance (HP:0002141)1.71002456
93Postaxial hand polydactyly (HP:0001162)1.70770829
94Tracheomalacia (HP:0002779)1.69976935
95Fibular hypoplasia (HP:0003038)1.68097591
96Skull defect (HP:0001362)1.67491122
97Abnormality of the right ventricle (HP:0001707)1.67457674
98Broad long bones (HP:0005622)1.67237969
99Aplasia/Hypoplasia of the hallux (HP:0008362)1.66958433
100Abnormal respiratory motile cilium physiology (HP:0012261)1.65586877
101Abnormality of molar (HP:0011077)1.64598316
102Abnormality of molar morphology (HP:0011070)1.64598316
103Anophthalmia (HP:0000528)1.63081518
104Hypoplastic left heart (HP:0004383)1.62778321
105Male pseudohermaphroditism (HP:0000037)1.62251773
106Bowel diverticulosis (HP:0005222)1.62212413
107Trigonocephaly (HP:0000243)1.61115558
108Nephrogenic diabetes insipidus (HP:0009806)1.60521413
109Megalencephaly (HP:0001355)1.60472260
110Tarsal synostosis (HP:0008368)1.60393600
111Oculomotor apraxia (HP:0000657)1.60073203
112Abnormality of the fetal cardiovascular system (HP:0010948)1.59971599
113Abnormal umbilical cord blood vessels (HP:0011403)1.59971599
114Single umbilical artery (HP:0001195)1.59971599
115Vascular tortuosity (HP:0004948)1.59571561
116Ankle contracture (HP:0006466)1.58106370
117Abnormality of the nasolacrimal system (HP:0000614)1.57187367
118Abnormal ciliary motility (HP:0012262)1.56643499
119Radial bowing (HP:0002986)1.56412321
120Limited hip movement (HP:0008800)1.56313377
121Abdominal situs inversus (HP:0003363)1.55589070
122Abnormality of abdominal situs (HP:0011620)1.55589070
123Abnormality of the frontal sinuses (HP:0002687)1.55508296
124Spinal cord compression (HP:0002176)1.55461030
125Median cleft lip (HP:0000161)1.55429841
126Broad hallux (HP:0010055)1.55073914
127Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.54860713
128Synostosis involving bones of the feet (HP:0009140)1.54566373
129Synostosis involving bones of the lower limbs (HP:0009138)1.54566373
130Generalized tonic-clonic seizures (HP:0002069)1.54284030
131Wormian bones (HP:0002645)1.54173148
132Tubulointerstitial abnormality (HP:0001969)1.53511318
133Renal duplication (HP:0000075)1.53365791
134Short thorax (HP:0010306)1.52891174
135Dilatation of the ascending aorta (HP:0005111)1.51621183
136Facial cleft (HP:0002006)1.51215651
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.50773024
138Natal tooth (HP:0000695)1.50741378
139Abnormality of incisor morphology (HP:0011063)1.50506813
140Alacrima (HP:0000522)1.50459295
141Abnormality of the dental root (HP:0006486)1.50455277
142Taurodontia (HP:0000679)1.50455277
143Abnormality of permanent molar morphology (HP:0011071)1.50455277
144Bradycardia (HP:0001662)1.50047592
145Epileptic encephalopathy (HP:0200134)1.49989943
146Genital tract atresia (HP:0001827)1.49614115
147Bifid tongue (HP:0010297)1.48956555
148Preaxial hand polydactyly (HP:0001177)1.47435504
149Hemiparesis (HP:0001269)1.47269372
150Hypoplasia of the maxilla (HP:0000327)1.47187827
151Vaginal atresia (HP:0000148)1.47003683
152Spinal cord lesions (HP:0100561)1.46532282
153Abnormality of the distal phalanges of the toes (HP:0010182)1.44594031
154Nephropathy (HP:0000112)1.42303103
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.41963443
156Renal salt wasting (HP:0000127)1.41497363
157Abnormality of the dental pulp (HP:0006479)1.40886396
158Asplenia (HP:0001746)1.40605725
159Hyperkalemia (HP:0002153)1.40025784
160Hand muscle atrophy (HP:0009130)1.38901766
161Stage 5 chronic kidney disease (HP:0003774)1.38741350
162Poor coordination (HP:0002370)1.34568563
163Furrowed tongue (HP:0000221)1.34446817
164Recurrent bronchitis (HP:0002837)1.29686762
165Broad distal phalanx of finger (HP:0009836)1.28246341
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.28092970
167Short ribs (HP:0000773)1.27277085
168Glucose intolerance (HP:0000833)1.26043983
169Aplasia of the musculature (HP:0100854)1.25283150
170Short femoral neck (HP:0100864)1.20525567
171Decreased circulating renin level (HP:0003351)1.19212527
172Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.17891062
173Cervical subluxation (HP:0003308)1.17718356
174Supernumerary spleens (HP:0009799)1.14656007
175Limb-girdle muscle atrophy (HP:0003797)1.13085716
176Renal dysplasia (HP:0000110)1.12806588
177Abnormality of chloride homeostasis (HP:0011422)1.11538800
178Hip dysplasia (HP:0001385)1.11363928
179Obstructive sleep apnea (HP:0002870)1.10278101
180Tubulointerstitial fibrosis (HP:0005576)1.09882545
181Narrow chest (HP:0000774)1.09816280
182Upper limb amyotrophy (HP:0009129)1.08123138
183Distal upper limb amyotrophy (HP:0007149)1.08123138
184Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.07121109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.26905289
2MST44.09658968
3DDR23.20297874
4NTRK33.02912944
5MAP2K72.58481583
6ZAK2.57960984
7ERBB32.48248714
8EPHB22.41310042
9CASK2.32289049
10TNIK2.27902833
11LATS12.19188300
12BMX1.98588277
13STK38L1.93310931
14PDGFRA1.88249128
15LATS21.87815221
16PLK21.74618081
17INSRR1.74097851
18PRPF4B1.73693280
19NME11.72954788
20MYLK1.71874832
21SMG11.68885287
22MST1R1.66544705
23PRKD31.61192532
24MAPK131.59004295
25MAPKAPK31.52341238
26PKN11.52266068
27BRD41.51383168
28RIPK11.50298847
29STK241.47009158
30PNCK1.46680940
31CDC42BPA1.43884401
32MAP3K71.42230190
33NTRK21.42123953
34TESK11.40264989
35PAK31.39923468
36AKT31.37376128
37PBK1.37217619
38FER1.34929951
39TTN1.34568629
40BRSK21.34559960
41MAP3K21.34252855
42TRPM71.33151037
43KSR11.29509440
44PLK41.26109894
45EEF2K1.25669302
46BMPR21.25619919
47SGK21.12583817
48CAMK1G1.11224298
49ERBB41.11092087
50CAMK11.11054704
51AKT21.08994530
52MINK11.06622855
53CAMK2B1.04641665
54FGFR11.03295508
55PRKCE1.02828838
56STK161.01437696
57PAK40.99805905
58LMTK20.96285854
59STK100.96228176
60MAP3K30.94619310
61STK30.93766719
62PLK30.93358069
63ROCK10.93105415
64WNK30.92758907
65MKNK20.89837668
66STK380.89699682
67ICK0.89551768
68NUAK10.87616550
69SGK4940.84292442
70SGK2230.84292442
71EIF2AK20.82705077
72CAMK2A0.82346866
73DMPK0.80605548
74CAMK2D0.80560515
75PTK20.80019667
76NTRK10.79014461
77MAP3K40.78048054
78CDK30.78034332
79EPHB10.77365725
80NEK90.74914752
81PRKCG0.74428900
82LRRK20.72680118
83MKNK10.71349733
84PHKG20.69888175
85PHKG10.69888175
86MAP4K20.69412750
87TSSK60.67745547
88CDK80.66773289
89EPHA20.66708465
90NEK20.64349730
91MELK0.63631708
92NEK60.63419831
93MARK20.61908752
94MARK10.61655878
95SRPK10.60981204
96FGFR20.60411643
97AURKA0.59873402
98SGK10.59461569
99TLK10.58937415
100ACVR1B0.57800916
101PTK2B0.57348446
102WEE10.57016666
103PRKCI0.55835703
104PLK10.55281336
105TAOK20.54967317
106CHEK20.51324342
107BCR0.50917961
108BMPR1B0.50908307
109DYRK1A0.50764657
110LIMK10.50753430
111SIK30.50036894
112SGK30.47676796
113TTK0.47567739
114AURKB0.47395065
115ADRBK10.47305840
116DAPK20.45556692
117CAMK2G0.45503698
118BRAF0.45337213
119PAK60.44161996
120CDK180.44067032
121PRKAA20.43833367
122MAPK150.43204289
123NLK0.43008570
124FRK0.42450640
125TIE10.42237191
126ROCK20.41920668
127CDK50.41251662
128PRKD20.41162185
129CDK150.39701539
130MTOR0.38717601
131ERBB20.38555731
132MAP3K120.38473303
133CSK0.38267505
134MET0.37935034
135SIK10.37718213
136PAK20.37557580
137PRKG10.37278443
138CDK90.37103419
139ARAF0.36450065
140CSNK1A10.36231077
141PRKCB0.35868996
142TGFBR10.35371014
143MAP2K10.35118106
144GSK3B0.34959919
145PDK20.34469372
146RPS6KA20.33967248
147CDK120.33923913
148PDGFRB0.32656594
149GRK70.31779442
150DYRK30.31021857
151TRIB30.25031793
152ABL20.24848221
153MUSK0.24809017
154MAP2K40.24418645
155PASK0.22207939

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.56675642
2Phenylalanine metabolism_Homo sapiens_hsa003604.06154437
3Histidine metabolism_Homo sapiens_hsa003403.70770559
4Chemical carcinogenesis_Homo sapiens_hsa052043.55272210
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.38887780
6Tyrosine metabolism_Homo sapiens_hsa003503.28971266
7Olfactory transduction_Homo sapiens_hsa047402.78408802
8Huntingtons disease_Homo sapiens_hsa050162.77351043
9beta-Alanine metabolism_Homo sapiens_hsa004102.73726396
10Nicotine addiction_Homo sapiens_hsa050332.62708862
11Basal cell carcinoma_Homo sapiens_hsa052172.48956762
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43717575
13Glutathione metabolism_Homo sapiens_hsa004802.42954150
14Circadian entrainment_Homo sapiens_hsa047132.38115748
15Morphine addiction_Homo sapiens_hsa050322.08582023
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00846923
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99511619
18Glutamatergic synapse_Homo sapiens_hsa047241.98545136
19Hedgehog signaling pathway_Homo sapiens_hsa043401.97464322
20GABAergic synapse_Homo sapiens_hsa047271.94805381
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94715935
22Insulin secretion_Homo sapiens_hsa049111.91716658
23ECM-receptor interaction_Homo sapiens_hsa045121.84684216
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.83169473
25Dilated cardiomyopathy_Homo sapiens_hsa054141.82840862
26Melanogenesis_Homo sapiens_hsa049161.74441954
27Amphetamine addiction_Homo sapiens_hsa050311.73705426
28Hippo signaling pathway_Homo sapiens_hsa043901.72842397
29Retinol metabolism_Homo sapiens_hsa008301.67844235
30Taste transduction_Homo sapiens_hsa047421.65707040
31Axon guidance_Homo sapiens_hsa043601.64931962
32Adherens junction_Homo sapiens_hsa045201.63911880
33Sphingolipid metabolism_Homo sapiens_hsa006001.50690343
34Salivary secretion_Homo sapiens_hsa049701.50417855
35Serotonergic synapse_Homo sapiens_hsa047261.49658830
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49135424
37Fatty acid degradation_Homo sapiens_hsa000711.49000016
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46867255
39Caffeine metabolism_Homo sapiens_hsa002321.45516995
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41383905
41Wnt signaling pathway_Homo sapiens_hsa043101.37816633
42Dopaminergic synapse_Homo sapiens_hsa047281.35698718
43Cholinergic synapse_Homo sapiens_hsa047251.35587905
44Cocaine addiction_Homo sapiens_hsa050301.34677666
45Gastric acid secretion_Homo sapiens_hsa049711.31014403
46Focal adhesion_Homo sapiens_hsa045101.30595566
47Calcium signaling pathway_Homo sapiens_hsa040201.29583890
48Long-term potentiation_Homo sapiens_hsa047201.29543531
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23677794
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22952704
51cAMP signaling pathway_Homo sapiens_hsa040241.20140771
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18929887
53ABC transporters_Homo sapiens_hsa020101.18829116
54Gap junction_Homo sapiens_hsa045401.17053818
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12319125
56Proteoglycans in cancer_Homo sapiens_hsa052051.11448904
57GnRH signaling pathway_Homo sapiens_hsa049121.10262361
58Ovarian steroidogenesis_Homo sapiens_hsa049131.10038154
59Rap1 signaling pathway_Homo sapiens_hsa040151.07480070
60Vitamin digestion and absorption_Homo sapiens_hsa049771.07221803
61Tight junction_Homo sapiens_hsa045301.04982776
62Oxytocin signaling pathway_Homo sapiens_hsa049211.04684206
63Melanoma_Homo sapiens_hsa052181.04528962
64Renin secretion_Homo sapiens_hsa049241.03822765
65MicroRNAs in cancer_Homo sapiens_hsa052061.03071447
66TGF-beta signaling pathway_Homo sapiens_hsa043501.02942190
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.01508795
68Alcoholism_Homo sapiens_hsa050341.01066699
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00815170
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00438193
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96377102
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95085914
73Phototransduction_Homo sapiens_hsa047440.91737850
74Glioma_Homo sapiens_hsa052140.91466790
75Protein digestion and absorption_Homo sapiens_hsa049740.90624951
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90188173
77Long-term depression_Homo sapiens_hsa047300.88712200
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88576380
79Folate biosynthesis_Homo sapiens_hsa007900.87400404
80Bladder cancer_Homo sapiens_hsa052190.84628680
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84580455
82Pathways in cancer_Homo sapiens_hsa052000.83615395
83Ras signaling pathway_Homo sapiens_hsa040140.83570273
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83410261
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83359529
86Thyroid hormone synthesis_Homo sapiens_hsa049180.79847675
87Peroxisome_Homo sapiens_hsa041460.79687818
88Synaptic vesicle cycle_Homo sapiens_hsa047210.79616869
89Starch and sucrose metabolism_Homo sapiens_hsa005000.79315461
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77391403
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77090325
92Arachidonic acid metabolism_Homo sapiens_hsa005900.76052246
93Estrogen signaling pathway_Homo sapiens_hsa049150.75393645
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.73736314
95Butanoate metabolism_Homo sapiens_hsa006500.73056764
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.71415874
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71270235
98ErbB signaling pathway_Homo sapiens_hsa040120.70426628
99Amoebiasis_Homo sapiens_hsa051460.70227110
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.69971576
101Dorso-ventral axis formation_Homo sapiens_hsa043200.66727786
102Small cell lung cancer_Homo sapiens_hsa052220.66041005
103Notch signaling pathway_Homo sapiens_hsa043300.65578530
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65106963
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63723582
106Ether lipid metabolism_Homo sapiens_hsa005650.62114477
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61142547
108Endometrial cancer_Homo sapiens_hsa052130.60213623
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60005950
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59443185
111Fanconi anemia pathway_Homo sapiens_hsa034600.59294391
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59077070
113Prostate cancer_Homo sapiens_hsa052150.58539251
114MAPK signaling pathway_Homo sapiens_hsa040100.57286149
115Mineral absorption_Homo sapiens_hsa049780.56674643
116Choline metabolism in cancer_Homo sapiens_hsa052310.56025155
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55871591
118HTLV-I infection_Homo sapiens_hsa051660.55119631
119Pyruvate metabolism_Homo sapiens_hsa006200.54661360
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52867317
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51903295
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51626785
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50015231
124Linoleic acid metabolism_Homo sapiens_hsa005910.49758332
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49356621
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.49308383
127Circadian rhythm_Homo sapiens_hsa047100.49051853
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48879221
129Pancreatic secretion_Homo sapiens_hsa049720.48458603
130Oocyte meiosis_Homo sapiens_hsa041140.46419626
131p53 signaling pathway_Homo sapiens_hsa041150.44617043
132Nucleotide excision repair_Homo sapiens_hsa034200.44419134
133Propanoate metabolism_Homo sapiens_hsa006400.44090082
134Metabolic pathways_Homo sapiens_hsa011000.43741121
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.43519797
136Cardiac muscle contraction_Homo sapiens_hsa042600.43227620
137Vibrio cholerae infection_Homo sapiens_hsa051100.42312056
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.42165363
139Lysosome_Homo sapiens_hsa041420.41520560
140Complement and coagulation cascades_Homo sapiens_hsa046100.39687398
141PPAR signaling pathway_Homo sapiens_hsa033200.38118552
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37091559
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35399336
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.31827905
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30830044
146Purine metabolism_Homo sapiens_hsa002300.30748804
147Fatty acid biosynthesis_Homo sapiens_hsa000610.30300769
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30276733
149Protein export_Homo sapiens_hsa030600.29540221
150Vitamin B6 metabolism_Homo sapiens_hsa007500.26415738
151Regulation of autophagy_Homo sapiens_hsa041400.25952016
152Lysine degradation_Homo sapiens_hsa003100.25081351
153Arginine and proline metabolism_Homo sapiens_hsa003300.24291445
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.24201906
155N-Glycan biosynthesis_Homo sapiens_hsa005100.24036022
156Tryptophan metabolism_Homo sapiens_hsa003800.23588589
157Glycerolipid metabolism_Homo sapiens_hsa005610.19710086
158Steroid biosynthesis_Homo sapiens_hsa001000.19472486

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