E2F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.56801736
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.74404388
3porphyrin-containing compound biosynthetic process (GO:0006779)5.68076476
4erythrocyte maturation (GO:0043249)5.61386004
5heme biosynthetic process (GO:0006783)5.21263820
6tetrapyrrole biosynthetic process (GO:0033014)4.94317361
7positive regulation of gamma-delta T cell activation (GO:0046645)4.84123440
8mitotic sister chromatid segregation (GO:0000070)4.72770832
9sister chromatid segregation (GO:0000819)4.71207161
10protein localization to kinetochore (GO:0034501)4.59857082
11oxygen transport (GO:0015671)4.56303908
12DNA unwinding involved in DNA replication (GO:0006268)4.46844041
13mitotic chromosome condensation (GO:0007076)4.46804194
14protein localization to chromosome, centromeric region (GO:0071459)4.46374737
15V(D)J recombination (GO:0033151)4.39617255
16porphyrin-containing compound metabolic process (GO:0006778)4.34814992
17erythrocyte development (GO:0048821)4.13246155
18nuclear pore complex assembly (GO:0051292)4.11048881
19regulation of gamma-delta T cell differentiation (GO:0045586)4.09014736
20DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.99382628
21regulation of histone H3-K9 methylation (GO:0051570)3.99379622
22heme metabolic process (GO:0042168)3.88600756
23replication fork processing (GO:0031297)3.77811266
24gas transport (GO:0015669)3.76555325
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.74443964
26gonadal mesoderm development (GO:0007506)3.69250440
27regulation of gamma-delta T cell activation (GO:0046643)3.67670723
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.66210155
29nuclear pore organization (GO:0006999)3.65485622
30positive regulation of granulocyte differentiation (GO:0030854)3.63853556
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.63654100
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63654100
33DNA damage response, signal transduction resulting in transcription (GO:0042772)3.61741505
34positive regulation of chromosome segregation (GO:0051984)3.60008342
35DNA strand elongation involved in DNA replication (GO:0006271)3.55807774
36chromatin assembly (GO:0031497)3.55139190
373-UTR-mediated mRNA stabilization (GO:0070935)3.55101335
38regulation of DNA endoreduplication (GO:0032875)3.54882572
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.53907131
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.53907131
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.53907131
42B cell receptor signaling pathway (GO:0050853)3.51421196
43negative regulation of histone methylation (GO:0031061)3.47610007
44hemoglobin metabolic process (GO:0020027)3.46314720
45positive regulation of B cell differentiation (GO:0045579)3.42004463
46erythrocyte differentiation (GO:0030218)3.41211387
47DNA strand elongation (GO:0022616)3.39704574
48DNA replication initiation (GO:0006270)3.36704556
49leukocyte aggregation (GO:0070486)3.36600522
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34593217
51protein K6-linked ubiquitination (GO:0085020)3.34495485
52hepatocyte apoptotic process (GO:0097284)3.32593659
53DNA replication checkpoint (GO:0000076)3.32259484
54telomere maintenance via telomere lengthening (GO:0010833)3.32205528
55mitotic sister chromatid cohesion (GO:0007064)3.31898063
56telomere maintenance via semi-conservative replication (GO:0032201)3.30065652
57DNA ligation (GO:0006266)3.29425723
58chromatin remodeling at centromere (GO:0031055)3.28304503
59regulation of centriole replication (GO:0046599)3.26044279
60myeloid cell development (GO:0061515)3.25132952
61protein localization to chromosome (GO:0034502)3.23611765
62CENP-A containing nucleosome assembly (GO:0034080)3.23060474
63attachment of spindle microtubules to kinetochore (GO:0008608)3.22255845
64somatic diversification of immune receptors (GO:0002200)3.20325267
65DNA replication-dependent nucleosome organization (GO:0034723)3.14921740
66DNA replication-dependent nucleosome assembly (GO:0006335)3.14921740
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.14382845
68kinetochore organization (GO:0051383)3.13324821
69chromatin assembly or disassembly (GO:0006333)3.12785027
70DNA conformation change (GO:0071103)3.11407630
71cellular hyperosmotic response (GO:0071474)3.11056876
72DNA packaging (GO:0006323)3.10797152
73pore complex assembly (GO:0046931)3.08656209
74DNA double-strand break processing (GO:0000729)3.06788465
75meiotic chromosome segregation (GO:0045132)3.06083124
76double-strand break repair via homologous recombination (GO:0000724)3.06074154
77sister chromatid cohesion (GO:0007062)3.06053045
78recombinational repair (GO:0000725)3.05976956
79mitotic recombination (GO:0006312)3.05450462
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05293334
81postreplication repair (GO:0006301)3.04791558
82DNA replication (GO:0006260)3.03499604
83positive regulation by host of viral transcription (GO:0043923)2.99584488
84DNA topological change (GO:0006265)2.99388586
85regulation of sister chromatid cohesion (GO:0007063)2.98754795
86kinetochore assembly (GO:0051382)2.97103173
87protein-DNA complex assembly (GO:0065004)2.96639924
88telomere maintenance via recombination (GO:0000722)2.96373332
89DNA replication-independent nucleosome assembly (GO:0006336)2.96300361
90DNA replication-independent nucleosome organization (GO:0034724)2.96300361
91embryonic hemopoiesis (GO:0035162)2.96139707
92positive thymic T cell selection (GO:0045059)2.94847580
93regulation of centrosome cycle (GO:0046605)2.92410612
94nuclear envelope disassembly (GO:0051081)2.91443318
95membrane disassembly (GO:0030397)2.91443318
96regulation of B cell differentiation (GO:0045577)2.90616489
97translesion synthesis (GO:0019985)2.90560877
98telomere maintenance (GO:0000723)2.90554720
99telomere organization (GO:0032200)2.89323655
100chromosome condensation (GO:0030261)2.89040520
101centriole replication (GO:0007099)2.87990057
102nucleosome organization (GO:0034728)2.85265067
103deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84724417
104protein-DNA complex subunit organization (GO:0071824)2.84253047
105DNA strand renaturation (GO:0000733)2.84160477
106megakaryocyte development (GO:0035855)2.83897652
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83455286
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83455286
109negative regulation of cell killing (GO:0031342)2.81921540
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81921540
111protein-DNA complex disassembly (GO:0032986)2.81798671
112nucleosome disassembly (GO:0006337)2.81798671
113double-strand break repair via nonhomologous end joining (GO:0006303)2.81017971
114non-recombinational repair (GO:0000726)2.81017971
115platelet formation (GO:0030220)2.81010282
116innate immune response in mucosa (GO:0002227)2.80690360
117DNA synthesis involved in DNA repair (GO:0000731)2.80528380
118nucleosome assembly (GO:0006334)2.80412077
119regulation of DNA-dependent DNA replication (GO:0090329)2.80394789
120chromosome segregation (GO:0007059)2.79285334
121regulation of exit from mitosis (GO:0007096)2.79096181
122DNA duplex unwinding (GO:0032508)2.77736733
123positive regulation of histone deacetylation (GO:0031065)2.76996858
124positive regulation of gene expression, epigenetic (GO:0045815)2.76505549
125microtubule depolymerization (GO:0007019)2.76421063
126DNA geometric change (GO:0032392)2.76092083
127mitotic nuclear envelope disassembly (GO:0007077)2.75883788
128negative regulation of phagocytosis (GO:0050765)2.74977388
129lymphocyte homeostasis (GO:0002260)2.73997136
130regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72806463
131mucosal-associated lymphoid tissue development (GO:0048537)2.71819243
132Peyers patch development (GO:0048541)2.71819243
133negative regulation of thymocyte apoptotic process (GO:0070244)2.70845468
134antigen processing and presentation of endogenous antigen (GO:0019883)2.68263518
135T cell selection (GO:0045058)2.66643087
136regulation of B cell receptor signaling pathway (GO:0050855)2.66583307
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.65964619
138mRNA stabilization (GO:0048255)2.65458522
139RNA stabilization (GO:0043489)2.65458522
140positive regulation of erythrocyte differentiation (GO:0045648)2.64920433
141regulation of erythrocyte differentiation (GO:0045646)2.64546156
142somatic cell DNA recombination (GO:0016444)2.63364170
143somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.63364170
144negative T cell selection (GO:0043383)2.62344881
145positive T cell selection (GO:0043368)2.62212934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human8.62256966
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.37841127
3MYC_22102868_ChIP-Seq_BL_Human3.74462852
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73530431
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58388877
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40723020
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21651101
8VDR_21846776_ChIP-Seq_THP-1_Human2.90540156
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75774995
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.64656315
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.48234386
12TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.38885573
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27730579
14* SCL_19346495_ChIP-Seq_HPC-7_Human2.20713114
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17983355
16GATA1_19941826_ChIP-Seq_K562_Human2.16508251
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16005797
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10260744
19GATA1_22025678_ChIP-Seq_K562_Human2.08849827
20* MAF_26560356_Chip-Seq_TH1_Human1.99673421
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98671476
22* E2F1_21310950_ChIP-Seq_MCF-7_Human1.98251937
23* UTX_26944678_Chip-Seq_JUKART_Human1.96245424
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94692240
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.92063997
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.87455693
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87147302
28* GATA1_19941827_ChIP-Seq_MEL_Mouse1.85205339
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.85069238
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82670050
31MYB_26560356_Chip-Seq_TH2_Human1.82244169
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.79634194
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78812933
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74113156
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.73162635
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72073991
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71383037
38VDR_24763502_ChIP-Seq_THP-1_Human1.70366282
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65970178
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64908247
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.64529319
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64114801
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63699752
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62998974
45CIITA_25753668_ChIP-Seq_RAJI_Human1.61359564
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60438360
47* MYB_26560356_Chip-Seq_TH1_Human1.59958424
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59646313
49* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58628437
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56277162
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55979941
52* KDM2B_26808549_Chip-Seq_DND41_Human1.55071746
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.53623580
54DCP1A_22483619_ChIP-Seq_HELA_Human1.53492568
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53026892
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50680813
57* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.50336971
58* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48302065
59AR_21909140_ChIP-Seq_LNCAP_Human1.47910778
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44075536
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42516751
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42288424
63GABP_19822575_ChIP-Seq_HepG2_Human1.40860465
64TTF2_22483619_ChIP-Seq_HELA_Human1.39862160
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39818314
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37048226
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.36687701
68SPI1_23547873_ChIP-Seq_NB4_Human1.31282300
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30701949
70* MAF_26560356_Chip-Seq_TH2_Human1.29810512
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27289522
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.27061131
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25523407
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25509511
75* GATA2_19941826_ChIP-Seq_K562_Human1.24558095
76* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24076892
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.23649541
78ELK1_19687146_ChIP-ChIP_HELA_Human1.23372035
79* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22208545
80* NCOR1_26117541_ChIP-Seq_K562_Human1.20988929
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20557635
82* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20400623
83IRF1_19129219_ChIP-ChIP_H3396_Human1.18421009
84* IRF8_27001747_Chip-Seq_BMDM_Mouse1.16471457
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16275830
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15879392
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14641200
88* KDM5A_27292631_Chip-Seq_BREAST_Human1.12960589
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12482573
90VDR_23849224_ChIP-Seq_CD4+_Human1.12340648
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11645609
92MYC_18940864_ChIP-ChIP_HL60_Human1.11362001
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11112510
94FOXP3_21729870_ChIP-Seq_TREG_Human1.10454511
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10117710
96* RUNX_20019798_ChIP-Seq_JUKART_Human1.09301040
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09015773
98MYC_18555785_ChIP-Seq_MESCs_Mouse1.06782461
99XRN2_22483619_ChIP-Seq_HELA_Human1.06591405
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06513310
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06143745
102SPI1_23127762_ChIP-Seq_K562_Human1.04988863
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04943342
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03157778
105* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02724271
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01150760
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.00847415
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00532483
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99957096
110E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99861654
111MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98388542
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97763593
113* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96525826
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93141520
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93011853
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91611682
117* GATA3_27048872_Chip-Seq_THYMUS_Human0.91384505
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90379503
119* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88294962
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88075697
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86466617
122MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86283223
123* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86122713
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85592053
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84876208
126TFEB_21752829_ChIP-Seq_HELA_Human0.84526139
127* KDM2B_26808549_Chip-Seq_JURKAT_Human0.84042487
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.83862797
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83662485
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83339271
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82994121
132ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82651104
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82212023
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81695573
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80977097
136CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78130692
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77976893
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.77233445
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.77000503
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76862645
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.76455668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.02452842
2MP0004147_increased_porphyrin_level3.52519147
3MP0010094_abnormal_chromosome_stability3.50251391
4MP0003111_abnormal_nucleus_morphology3.44044259
5MP0003693_abnormal_embryo_hatching2.73839470
6MP0003077_abnormal_cell_cycle2.71160513
7* MP0002398_abnormal_bone_marrow2.59272181
8MP0002396_abnormal_hematopoietic_system2.52309939
9MP0001800_abnormal_humoral_immune2.45671296
10MP0003303_peritoneal_inflammation2.41672843
11MP0005397_hematopoietic_system_phenotyp2.41203118
12MP0001545_abnormal_hematopoietic_system2.41203118
13MP0009278_abnormal_bone_marrow2.38775593
14MP0008057_abnormal_DNA_replication2.33977016
15MP0008995_early_reproductive_senescence2.31507855
16MP0003763_abnormal_thymus_physiology2.18104597
17* MP0002722_abnormal_immune_system2.18067332
18* MP0000689_abnormal_spleen_morphology2.17271055
19* MP0000703_abnormal_thymus_morphology2.13104224
20MP0010307_abnormal_tumor_latency2.09733132
21MP0004808_abnormal_hematopoietic_stem2.07658228
22MP0005671_abnormal_response_to2.06362080
23MP0004957_abnormal_blastocyst_morpholog2.05911937
24MP0003300_gastrointestinal_ulcer2.04466376
25MP0003786_premature_aging2.03991288
26* MP0000685_abnormal_immune_system2.01388778
27MP0001835_abnormal_antigen_presentation2.01259666
28MP0002166_altered_tumor_susceptibility1.95645334
29MP0005075_abnormal_melanosome_morpholog1.94561432
30MP0005076_abnormal_cell_differentiation1.93210657
31MP0002452_abnormal_antigen_presenting1.92457837
32* MP0002429_abnormal_blood_cell1.87991154
33* MP0000716_abnormal_immune_system1.87015683
34* MP0002420_abnormal_adaptive_immunity1.86793746
35MP0002163_abnormal_gland_morphology1.85383418
36* MP0001819_abnormal_immune_cell1.83374737
37MP0000490_abnormal_crypts_of1.83021620
38* MP0005387_immune_system_phenotype1.82322658
39* MP0001790_abnormal_immune_system1.82322658
40MP0003436_decreased_susceptibility_to1.74791428
41MP0000015_abnormal_ear_pigmentation1.73161871
42MP0002723_abnormal_immune_serum1.72248252
43MP0009333_abnormal_splenocyte_physiolog1.71453038
44MP0002019_abnormal_tumor_incidence1.66930204
45MP0000350_abnormal_cell_proliferation1.62963330
46MP0005464_abnormal_platelet_physiology1.57800507
47* MP0005000_abnormal_immune_tolerance1.53889525
48MP0004947_skin_inflammation1.53623156
49MP0010352_gastrointestinal_tract_polyps1.52956032
50MP0009697_abnormal_copulation1.51641527
51MP0005025_abnormal_response_to1.48188859
52MP0004381_abnormal_hair_follicle1.46895966
53* MP0002405_respiratory_system_inflammati1.46731218
54MP0002132_abnormal_respiratory_system1.46707241
55MP0002006_tumorigenesis1.42276185
56MP0006054_spinal_hemorrhage1.38365466
57MP0001730_embryonic_growth_arrest1.38042262
58MP0009785_altered_susceptibility_to1.35995837
59MP0008058_abnormal_DNA_repair1.34117217
60MP0010155_abnormal_intestine_physiology1.32488206
61MP0005083_abnormal_biliary_tract1.29953287
62MP0000372_irregular_coat_pigmentation1.25246130
63MP0002210_abnormal_sex_determination1.22103680
64MP0006035_abnormal_mitochondrial_morpho1.19408174
65MP0001929_abnormal_gametogenesis1.18975070
66MP0005174_abnormal_tail_pigmentation1.18498994
67MP0000465_gastrointestinal_hemorrhage1.17401570
68MP0002419_abnormal_innate_immunity1.14611646
69MP0008007_abnormal_cellular_replicative1.14534064
70MP0001873_stomach_inflammation1.14473820
71* MP0000313_abnormal_cell_death1.13770851
72MP0003866_abnormal_defecation1.06889889
73MP0005501_abnormal_skin_physiology1.02485396
74MP0000858_altered_metastatic_potential1.01611400
75MP0003943_abnormal_hepatobiliary_system1.01515959
76* MP0009931_abnormal_skin_appearance1.00993486
77MP0002095_abnormal_skin_pigmentation1.00473141
78MP0005310_abnormal_salivary_gland1.00035760
79* MP0001845_abnormal_inflammatory_respons0.99251915
80MP0008877_abnormal_DNA_methylation0.97288415
81MP0001145_abnormal_male_reproductive0.96528356
82MP0001529_abnormal_vocalization0.96484971
83MP0002080_prenatal_lethality0.95805535
84MP0001697_abnormal_embryo_size0.94035858
85MP0003705_abnormal_hypodermis_morpholog0.93274824
86MP0002086_abnormal_extraembryonic_tissu0.92898157
87MP0001986_abnormal_taste_sensitivity0.91227467
88MP0005379_endocrine/exocrine_gland_phen0.90610748
89MP0003698_abnormal_male_reproductive0.89234652
90MP0000653_abnormal_sex_gland0.88147874
91MP0005220_abnormal_exocrine_pancreas0.86927766
92MP0005380_embryogenesis_phenotype0.86747749
93MP0001672_abnormal_embryogenesis/_devel0.86747749
94MP0001919_abnormal_reproductive_system0.86585307
95MP0003453_abnormal_keratinocyte_physiol0.85211413
96MP0003448_altered_tumor_morphology0.84548897
97MP0003984_embryonic_growth_retardation0.83340851
98MP0008770_decreased_survivor_rate0.82825009
99MP0001849_ear_inflammation0.82740995
100MP0004197_abnormal_fetal_growth/weight/0.82707270
101MP0005645_abnormal_hypothalamus_physiol0.81323086
102MP0001119_abnormal_female_reproductive0.81254491
103MP0002088_abnormal_embryonic_growth/wei0.80386507
104MP0003566_abnormal_cell_adhesion0.80040907
105MP0000569_abnormal_digit_pigmentation0.78913719
106MP0006036_abnormal_mitochondrial_physio0.77531014
107MP0002933_joint_inflammation0.76907956
108MP0001346_abnormal_lacrimal_gland0.74977055
109MP0002009_preneoplasia0.74694006
110* MP0005621_abnormal_cell_physiology0.74469133
111MP0006292_abnormal_olfactory_placode0.71515470
112MP0004185_abnormal_adipocyte_glucose0.69800813
113MP0008932_abnormal_embryonic_tissue0.69352172
114MP0002970_abnormal_white_adipose0.68840619
115MP0005389_reproductive_system_phenotype0.68457111
116MP0003890_abnormal_embryonic-extraembry0.68279627
117MP0000358_abnormal_cell_content/0.66072018
118MP0001853_heart_inflammation0.65792813
119MP0000477_abnormal_intestine_morphology0.65701212
120MP0005636_abnormal_mineral_homeostasis0.64153852
121MP0003787_abnormal_imprinting0.64114045
122MP0002148_abnormal_hypersensitivity_rea0.63369893
123MP0005266_abnormal_metabolism0.63305993
124MP0005023_abnormal_wound_healing0.63175999
125MP0002085_abnormal_embryonic_tissue0.63044820
126MP0002075_abnormal_coat/hair_pigmentati0.62296679
127MP0002877_abnormal_melanocyte_morpholog0.61286124
128MP0001243_abnormal_dermal_layer0.60675900
129MP0001915_intracranial_hemorrhage0.60487705
130MP0001216_abnormal_epidermal_layer0.60403469
131MP0002822_catalepsy0.60154735
132* MP0005384_cellular_phenotype0.60009454
133MP0001661_extended_life_span0.59918196
134* MP0002083_premature_death0.59010588
135MP0003699_abnormal_female_reproductive0.58818438
136MP0000631_abnormal_neuroendocrine_gland0.58693474
137MP0001663_abnormal_digestive_system0.58607092
138MP0001784_abnormal_fluid_regulation0.58095274
139MP0005377_hearing/vestibular/ear_phenot0.57846437
140MP0003878_abnormal_ear_physiology0.57846437
141MP0000427_abnormal_hair_cycle0.57253543
142MP0002928_abnormal_bile_duct0.57126975

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)7.36371912
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.82350742
3Acanthocytosis (HP:0001927)5.30377896
4Hypochromic microcytic anemia (HP:0004840)4.98210864
5B lymphocytopenia (HP:0010976)4.87255758
6Abnormality of B cell number (HP:0010975)4.87255758
7Reticulocytosis (HP:0001923)4.87069390
8Papilloma (HP:0012740)4.51162137
9Verrucae (HP:0200043)4.51162137
10T lymphocytopenia (HP:0005403)4.17426180
11Cellulitis (HP:0100658)4.17351243
12Recurrent viral infections (HP:0004429)4.14902379
13Panhypogammaglobulinemia (HP:0003139)3.98064339
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.94902256
15Abnormality of T cell number (HP:0011839)3.93862701
16Thyroiditis (HP:0100646)3.88881256
17Agammaglobulinemia (HP:0004432)3.86857590
18Combined immunodeficiency (HP:0005387)3.76016520
19Abnormality of reticulocytes (HP:0004312)3.67388290
20Hypochromic anemia (HP:0001931)3.67222460
21Abnormality of the fingertips (HP:0001211)3.54820950
22Abnormality of the preputium (HP:0100587)3.52999533
23Meckel diverticulum (HP:0002245)3.51629814
24Severe combined immunodeficiency (HP:0004430)3.46249042
25Abnormality of the ileum (HP:0001549)3.43858704
26Paralysis (HP:0003470)3.34131842
27Pustule (HP:0200039)3.31493828
28Recurrent fungal infections (HP:0002841)3.21966700
29Meningitis (HP:0001287)3.17743107
30Ectopic kidney (HP:0000086)3.11613553
31IgM deficiency (HP:0002850)2.98748019
32Duodenal stenosis (HP:0100867)2.94149751
33Small intestinal stenosis (HP:0012848)2.94149751
34Duplicated collecting system (HP:0000081)2.93905380
35Recurrent bronchitis (HP:0002837)2.93747572
36Microcytic anemia (HP:0001935)2.91754265
37Cholelithiasis (HP:0001081)2.87755995
38Abnormality of the carotid arteries (HP:0005344)2.84205772
39Clubbing of toes (HP:0100760)2.84008770
40Abnormality of T cells (HP:0002843)2.82240263
41Basal cell carcinoma (HP:0002671)2.75740542
42Eosinophilia (HP:0001880)2.73033953
43Gastrointestinal inflammation (HP:0004386)2.70234570
44Cutaneous photosensitivity (HP:0000992)2.68258589
45Colitis (HP:0002583)2.67457258
46Abnormal number of erythroid precursors (HP:0012131)2.66038116
47Inflammation of the large intestine (HP:0002037)2.65211971
48Recurrent sinusitis (HP:0011108)2.64479132
49Abnormal hemoglobin (HP:0011902)2.63071288
50Sloping forehead (HP:0000340)2.62075056
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.61167318
52Abnormality of the renal collecting system (HP:0004742)2.58887092
53Hypoplasia of the thymus (HP:0000778)2.58568567
54Recurrent abscess formation (HP:0002722)2.58098641
55Reticulocytopenia (HP:0001896)2.56362848
56Small epiphyses (HP:0010585)2.55219693
57Abnormality of cells of the erythroid lineage (HP:0012130)2.51321848
58Absent thumb (HP:0009777)2.50556764
59Insomnia (HP:0100785)2.49532921
60Abnormal gallbladder morphology (HP:0012437)2.49264058
61Autoimmune thrombocytopenia (HP:0001973)2.48170584
62IgG deficiency (HP:0004315)2.47309747
63Osteomalacia (HP:0002749)2.46306413
64Osteomyelitis (HP:0002754)2.44705769
65Volvulus (HP:0002580)2.44450282
66Hyperbilirubinemia (HP:0002904)2.44409785
67Abnormality of the duodenum (HP:0002246)2.42689520
68Diaphragmatic weakness (HP:0009113)2.41695555
69Abnormality of DNA repair (HP:0003254)2.40929934
70Sepsis (HP:0100806)2.40189962
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.37306610
72Urticaria (HP:0001025)2.35747195
73Birth length less than 3rd percentile (HP:0003561)2.34890923
74Granulocytopenia (HP:0001913)2.30712028
75Eczematoid dermatitis (HP:0000976)2.30039552
76Impulsivity (HP:0100710)2.28466463
77Pallor (HP:0000980)2.28106089
78Abnormality of chromosome segregation (HP:0002916)2.27055279
79Bone marrow hypocellularity (HP:0005528)2.25742349
80Petechiae (HP:0000967)2.25621875
81Lymphoma (HP:0002665)2.24449799
82High pitched voice (HP:0001620)2.23601189
83Spontaneous hematomas (HP:0007420)2.23489699
84Prolonged bleeding time (HP:0003010)2.21601001
85Recurrent bacterial skin infections (HP:0005406)2.21038414
86Aplasia/Hypoplasia of the earlobes (HP:0009906)2.19347315
87Polycythemia (HP:0001901)2.18548537
88Squamous cell carcinoma (HP:0002860)2.15442509
89Short thumb (HP:0009778)2.12502791
90Abnormality of eosinophils (HP:0001879)2.10474774
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.05624018
92Lymphopenia (HP:0001888)2.05151138
93Chronic otitis media (HP:0000389)2.03939218
94Leukocytosis (HP:0001974)2.02730152
95Chromsome breakage (HP:0040012)2.00435607
96Aplasia/Hypoplasia of the thymus (HP:0010515)2.00226724
97Patellar aplasia (HP:0006443)1.99858612
98Neoplasm of the adrenal cortex (HP:0100641)1.98994444
99Recurrent otitis media (HP:0000403)1.98697606
100Obstructive lung disease (HP:0006536)1.98215222
101Chronic obstructive pulmonary disease (HP:0006510)1.98215222
102Cafe-au-lait spot (HP:0000957)1.97872310
103Abnormality of chromosome stability (HP:0003220)1.97129073
104Abnormality of the intervertebral disk (HP:0005108)1.94506461
105Acute lymphatic leukemia (HP:0006721)1.94336565
106Abnormal platelet volume (HP:0011876)1.93198744
107Abnormality of cochlea (HP:0000375)1.91949535
108Nephroblastoma (Wilms tumor) (HP:0002667)1.91536425
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91096142
110Triphalangeal thumb (HP:0001199)1.90329636
111Homocystinuria (HP:0002156)1.87352133
112Abnormality of homocysteine metabolism (HP:0010919)1.87352133
113Prominent nose (HP:0000448)1.86973088
114Long eyelashes (HP:0000527)1.86646934
115Vertebral arch anomaly (HP:0008438)1.85522084
116Breast hypoplasia (HP:0003187)1.85286257
117Chronic mucocutaneous candidiasis (HP:0002728)1.85114715
118Recurrent cutaneous fungal infections (HP:0011370)1.85114715
119Arteriovenous malformation (HP:0100026)1.84033825
120Autoimmune hemolytic anemia (HP:0001890)1.83759480
121Ulnar bowing (HP:0003031)1.83584915
122Horseshoe kidney (HP:0000085)1.83427400
123Abnormality of the labia minora (HP:0012880)1.81630579
124Aplasia/Hypoplasia of the patella (HP:0006498)1.80848476
125Mediastinal lymphadenopathy (HP:0100721)1.78971867
126Myelodysplasia (HP:0002863)1.78593024
127Abnormality of the thymus (HP:0000777)1.78478363
128Embryonal neoplasm (HP:0002898)1.78413680
129Nasal polyposis (HP:0100582)1.77000079
130Absent radius (HP:0003974)1.76597572
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76017450
132Absent epiphyses (HP:0010577)1.76017450
133Abnormality of the gallbladder (HP:0005264)1.74896779
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74587932
135Recurrent pneumonia (HP:0006532)1.74504669
136Embryonal renal neoplasm (HP:0011794)1.73931730
137Abnormality of T cell physiology (HP:0011840)1.72201110
138Increased IgE level (HP:0003212)1.71890462
139Epistaxis (HP:0000421)1.71882528
140Absent forearm bone (HP:0003953)1.70952455
141Aplasia involving forearm bones (HP:0009822)1.70952455
142IgA deficiency (HP:0002720)1.70498299
143Hypoplastic iliac wings (HP:0002866)1.67529242
144Colon cancer (HP:0003003)1.66958808
145Limb hypertonia (HP:0002509)1.62343923
146Albinism (HP:0001022)1.59587733
147Abnormality of pyrimidine metabolism (HP:0004353)1.59163308
148Hypoplasia of the pons (HP:0012110)1.56791805
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.56567480
150Oligodactyly (hands) (HP:0001180)1.55571674
151Abnormality of the pons (HP:0007361)1.55468206
152Microvesicular hepatic steatosis (HP:0001414)1.51530590
153Upslanted palpebral fissure (HP:0000582)1.51239118
154Carpal bone hypoplasia (HP:0001498)1.50698120
155Ependymoma (HP:0002888)1.50206956
156High anterior hairline (HP:0009890)1.49949053
157Poikiloderma (HP:0001029)1.49768734
158Cholecystitis (HP:0001082)1.49116035
159Abnormal gallbladder physiology (HP:0012438)1.49116035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.28321879
2MAP4K13.59331960
3CDC73.34456666
4EEF2K3.23437719
5STK102.90826814
6GRK62.88237879
7CDK122.87977437
8NEK22.76373625
9STK42.65710378
10EIF2AK12.47701086
11TLK12.38267412
12TRIB32.13831321
13PLK42.13448793
14PRPF4B2.05976505
15SMG11.96537298
16ERN11.87751133
17TAF11.85921698
18CDK41.75951005
19SYK1.70947859
20PLK31.70243705
21PKN21.69111184
22PIM11.60314917
23CDK81.53584207
24BUB11.44064309
25FRK1.41700548
26BLK1.39930533
27TAOK21.38605746
28VRK21.36520304
29BRSK11.35904953
30MAPK111.35331911
31CDK91.32075315
32MAP3K81.30509389
33CLK11.30421556
34DYRK31.27813543
35LRRK21.26792940
36BMPR1B1.25817701
37ZAP701.24684385
38RPS6KB21.23716616
39BTK1.22988853
40NUAK11.22435526
41MELK1.21553312
42SRPK11.21228804
43CDK61.20777166
44MKNK21.17723400
45AURKB1.13464205
46CHEK21.10770483
47SIK21.10128732
48BRD41.05521352
49TRIM281.04515229
50TYK20.98084369
51NME20.96478743
52TAOK10.95808968
53TRPM70.95728758
54CSK0.93794999
55ACVR1B0.92258189
56CSF1R0.91641832
57TTK0.91358328
58TESK20.90651664
59CHEK10.90338113
60EIF2AK30.89780191
61ATR0.89756433
62JAK30.84568185
63INSRR0.84063660
64LYN0.83949633
65NLK0.82125239
66MAPKAPK30.82110742
67WEE10.81749304
68ITK0.80488029
69DYRK1B0.80323646
70LCK0.79985881
71STK30.77129749
72RPS6KA40.77113631
73HCK0.76496791
74PLK10.75852772
75RPS6KA50.72217508
76NEK10.71870341
77CAMK1G0.71009133
78MARK30.70677742
79MAP2K30.70078523
80CCNB10.69654446
81HIPK20.66756950
82MKNK10.66037689
83SCYL20.65655597
84ATM0.64829327
85MAP3K110.64477120
86STK160.63757776
87RIPK40.63160260
88ICK0.62894657
89AURKA0.62338460
90VRK10.61242657
91TSSK60.61186771
92MAPKAPK20.58708055
93JAK20.58205533
94CDK70.57724871
95TNK20.57518232
96TXK0.57203425
97CDK20.56961226
98MAPK130.55776233
99WNK10.55591293
100ZAK0.54953928
101SIK30.54031160
102DYRK20.53564873
103MST40.51911553
104IKBKE0.51291578
105MAP3K30.49819238
106PTK60.48967302
107ALK0.48236578
108CAMK40.47435328
109CDK30.47238489
110CSNK1D0.45372083
111FGFR30.44190548
112PASK0.43965091
113BMX0.43468669
114PRKAA10.43228441
115RPS6KA60.40537043
116CDK10.39943294
117TAOK30.38842892
118STK240.38717933
119TBK10.38678531
120AKT10.38622375
121TEC0.37914669
122BRSK20.36865499
123EIF2AK20.36640445
124MAP3K70.36351739
125SGK30.36123125
126MAPK40.35967780
127MTOR0.35929288
128IRAK40.35329449
129FES0.35312493
130IKBKB0.35307266
131PRKCQ0.35095095
132BRAF0.34538115
133CHUK0.33423783
134MAPK140.33359360
135CSNK2A10.33314973
136MAP2K20.32364449
137TGFBR20.32039315
138MAPK120.31134861
139KSR10.30788259
140PRKDC0.30418694
141FGR0.29325376
142CAMK1D0.28494240

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.86495297
2Primary immunodeficiency_Homo sapiens_hsa053403.84247165
3Systemic lupus erythematosus_Homo sapiens_hsa053223.69590803
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.03238617
5* Cell cycle_Homo sapiens_hsa041102.69834827
6Mismatch repair_Homo sapiens_hsa034302.68414452
7Non-homologous end-joining_Homo sapiens_hsa034502.63362165
8Base excision repair_Homo sapiens_hsa034102.57836529
9B cell receptor signaling pathway_Homo sapiens_hsa046622.49863411
10Alcoholism_Homo sapiens_hsa050341.92406289
11Viral carcinogenesis_Homo sapiens_hsa052031.86771550
12Homologous recombination_Homo sapiens_hsa034401.86718537
13Hematopoietic cell lineage_Homo sapiens_hsa046401.84632840
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70729130
15RNA polymerase_Homo sapiens_hsa030201.69660653
16p53 signaling pathway_Homo sapiens_hsa041151.63720767
17Spliceosome_Homo sapiens_hsa030401.60720393
18Fanconi anemia pathway_Homo sapiens_hsa034601.58218050
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.57818536
20Nucleotide excision repair_Homo sapiens_hsa034201.57629565
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.53132457
22Basal transcription factors_Homo sapiens_hsa030221.52088154
23T cell receptor signaling pathway_Homo sapiens_hsa046601.50773096
24Vitamin B6 metabolism_Homo sapiens_hsa007501.50645491
25Antigen processing and presentation_Homo sapiens_hsa046121.48827838
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48290837
27* Chronic myeloid leukemia_Homo sapiens_hsa052201.44417344
28Measles_Homo sapiens_hsa051621.43426056
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42859280
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42321291
31Herpes simplex infection_Homo sapiens_hsa051681.41260486
32mRNA surveillance pathway_Homo sapiens_hsa030151.39539585
33Leishmaniasis_Homo sapiens_hsa051401.34180921
34Osteoclast differentiation_Homo sapiens_hsa043801.33075530
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28648556
36Apoptosis_Homo sapiens_hsa042101.28056661
37RNA transport_Homo sapiens_hsa030131.25099496
38One carbon pool by folate_Homo sapiens_hsa006701.18159398
39* Non-small cell lung cancer_Homo sapiens_hsa052231.17807329
40Acute myeloid leukemia_Homo sapiens_hsa052211.12498279
41* HTLV-I infection_Homo sapiens_hsa051661.12484833
42* Hepatitis B_Homo sapiens_hsa051611.09532687
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09289288
44Epstein-Barr virus infection_Homo sapiens_hsa051691.07850419
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.04235524
46Selenocompound metabolism_Homo sapiens_hsa004501.02544240
47* Pancreatic cancer_Homo sapiens_hsa052121.01760828
48Purine metabolism_Homo sapiens_hsa002301.00152782
49* MicroRNAs in cancer_Homo sapiens_hsa052060.98014295
50Proteasome_Homo sapiens_hsa030500.96835515
51Lysine degradation_Homo sapiens_hsa003100.90579781
52Chemokine signaling pathway_Homo sapiens_hsa040620.89351612
53Regulation of autophagy_Homo sapiens_hsa041400.88054871
54FoxO signaling pathway_Homo sapiens_hsa040680.87554073
55Shigellosis_Homo sapiens_hsa051310.87219059
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85806393
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.84348101
58Platelet activation_Homo sapiens_hsa046110.84147284
59* Small cell lung cancer_Homo sapiens_hsa052220.82817585
60Butanoate metabolism_Homo sapiens_hsa006500.81759250
61Influenza A_Homo sapiens_hsa051640.81128333
62Colorectal cancer_Homo sapiens_hsa052100.79677119
63RNA degradation_Homo sapiens_hsa030180.79272589
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78212069
65Toxoplasmosis_Homo sapiens_hsa051450.76010624
66Malaria_Homo sapiens_hsa051440.74663968
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74661952
68Ribosome_Homo sapiens_hsa030100.73415271
69Pentose phosphate pathway_Homo sapiens_hsa000300.71728192
70Thyroid cancer_Homo sapiens_hsa052160.69834841
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69328033
72Sulfur relay system_Homo sapiens_hsa041220.65946188
73VEGF signaling pathway_Homo sapiens_hsa043700.65602386
74Pyrimidine metabolism_Homo sapiens_hsa002400.65241721
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64639876
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62809842
77Tuberculosis_Homo sapiens_hsa051520.62545464
78Nitrogen metabolism_Homo sapiens_hsa009100.62458589
79Endometrial cancer_Homo sapiens_hsa052130.62444965
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.62227320
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61879764
82mTOR signaling pathway_Homo sapiens_hsa041500.61645354
83Protein export_Homo sapiens_hsa030600.61572531
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61424996
85Oocyte meiosis_Homo sapiens_hsa041140.60978533
86Viral myocarditis_Homo sapiens_hsa054160.60629227
87* Prostate cancer_Homo sapiens_hsa052150.58342361
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55965860
89Notch signaling pathway_Homo sapiens_hsa043300.55279011
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54945892
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54492752
92Dorso-ventral axis formation_Homo sapiens_hsa043200.52794761
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51625695
94Renal cell carcinoma_Homo sapiens_hsa052110.50375715
95Hepatitis C_Homo sapiens_hsa051600.49408666
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47688430
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46840124
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45938628
99Prolactin signaling pathway_Homo sapiens_hsa049170.44966049
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44751709
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44280386
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43644765
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43319718
104Insulin resistance_Homo sapiens_hsa049310.42516283
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42475572
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.41853392
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41040539
108Endocytosis_Homo sapiens_hsa041440.40874390
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40789830
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40221266
111Inositol phosphate metabolism_Homo sapiens_hsa005620.40020276
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39723057
113* Bladder cancer_Homo sapiens_hsa052190.39637680
114ABC transporters_Homo sapiens_hsa020100.39587264
115N-Glycan biosynthesis_Homo sapiens_hsa005100.38062050
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.37104468
117Legionellosis_Homo sapiens_hsa051340.36509210
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35376580
119Staphylococcus aureus infection_Homo sapiens_hsa051500.35210542
120HIF-1 signaling pathway_Homo sapiens_hsa040660.35090156
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34111566
122Proteoglycans in cancer_Homo sapiens_hsa052050.32455777
123TNF signaling pathway_Homo sapiens_hsa046680.32387329
124AMPK signaling pathway_Homo sapiens_hsa041520.31469491
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.31073911
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30224359
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29374562
128Phototransduction_Homo sapiens_hsa047440.26360522
129Folate biosynthesis_Homo sapiens_hsa007900.24973773
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24398969
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20753633
132Biosynthesis of amino acids_Homo sapiens_hsa012300.20476644
133* Melanoma_Homo sapiens_hsa052180.19450557
134Metabolic pathways_Homo sapiens_hsa011000.17514146
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17318651
136* Glioma_Homo sapiens_hsa052140.17008360
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16683620

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