E2F3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.12453679
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.63963677
3negative regulation of cell killing (GO:0031342)6.63963677
4negative T cell selection (GO:0043383)6.44193272
5negative thymic T cell selection (GO:0045060)6.20600247
6regulation of B cell receptor signaling pathway (GO:0050855)5.90640692
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.67387420
8positive T cell selection (GO:0043368)5.62212331
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61524364
10regulation of gamma-delta T cell differentiation (GO:0045586)5.45251779
11positive thymic T cell selection (GO:0045059)5.34122538
12regulation of gamma-delta T cell activation (GO:0046643)5.24240122
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11715027
14activated T cell proliferation (GO:0050798)5.02670254
15T cell selection (GO:0045058)4.90835104
16response to interleukin-15 (GO:0070672)4.88214542
17T cell migration (GO:0072678)4.82789406
18negative regulation of T cell mediated immunity (GO:0002710)4.78970159
19thymic T cell selection (GO:0045061)4.74055295
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72890358
21antigen processing and presentation of endogenous antigen (GO:0019883)4.72494324
22leukocyte aggregation (GO:0070486)4.57524275
23cellular response to interleukin-15 (GO:0071350)4.55247205
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.46789811
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.46789811
26modulation by symbiont of host immune response (GO:0052553)4.46789811
27positive regulation by symbiont of host defense response (GO:0052509)4.46789811
28modulation by symbiont of host defense response (GO:0052031)4.46789811
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.46789811
30hepatocyte apoptotic process (GO:0097284)4.41812411
31positive regulation of granulocyte differentiation (GO:0030854)4.37013577
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.28853543
33interferon-gamma production (GO:0032609)4.18400491
34histone H3-K9 demethylation (GO:0033169)4.12615840
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.03637635
36tolerance induction (GO:0002507)4.03131553
37B cell receptor signaling pathway (GO:0050853)4.01982663
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.93911112
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.93258536
40regulation of alpha-beta T cell proliferation (GO:0046640)3.87392860
41histone H3-K36 demethylation (GO:0070544)3.81982646
42regulation of B cell differentiation (GO:0045577)3.79127549
43microglial cell activation (GO:0001774)3.76927230
44cellular extravasation (GO:0045123)3.74947095
45regulation of isotype switching to IgG isotypes (GO:0048302)3.66998530
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.62124182
47detection of molecule of bacterial origin (GO:0032490)3.46484949
48negative regulation of interleukin-12 production (GO:0032695)3.45447914
49negative regulation of leukocyte mediated immunity (GO:0002704)3.45315565
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.44481563
51macrophage activation involved in immune response (GO:0002281)3.44095941
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.40803815
53positive regulation of B cell differentiation (GO:0045579)3.39948861
54regulation of T cell tolerance induction (GO:0002664)3.35844116
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.29416764
56positive regulation of humoral immune response (GO:0002922)3.29244528
57detection of other organism (GO:0098543)3.27120702
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.25054889
59regulation of regulatory T cell differentiation (GO:0045589)3.23873182
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23152811
61positive regulation of tolerance induction (GO:0002645)3.22876329
62T cell proliferation (GO:0042098)3.22057860
63antigen receptor-mediated signaling pathway (GO:0050851)3.21968055
64histone lysine demethylation (GO:0070076)3.21928938
65T cell receptor signaling pathway (GO:0050852)3.20092298
66regulation of tolerance induction (GO:0002643)3.19724354
67natural killer cell differentiation (GO:0001779)3.17204937
68response to host immune response (GO:0052572)3.15584626
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15584626
70detection of external biotic stimulus (GO:0098581)3.11576460
71antigen processing and presentation via MHC class Ib (GO:0002475)3.08855172
72response to type I interferon (GO:0034340)3.07495874
73histone demethylation (GO:0016577)3.06736739
74lymph node development (GO:0048535)3.06177801
75cellular response to type I interferon (GO:0071357)3.06048956
76type I interferon signaling pathway (GO:0060337)3.06048956
77regulation of interleukin-2 biosynthetic process (GO:0045076)3.05553642
78regulation of interferon-beta biosynthetic process (GO:0045357)3.05108196
79histone H3-K4 trimethylation (GO:0080182)3.03223287
80negative regulation of B cell proliferation (GO:0030889)3.02919177
81neutrophil mediated immunity (GO:0002446)3.01740545
82response to host (GO:0075136)3.01379748
83response to host defenses (GO:0052200)3.01379748
84response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01379748
85regulation of natural killer cell mediated immunity (GO:0002715)2.99881955
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99881955
87detection of bacterium (GO:0016045)2.98916150
88T cell homeostasis (GO:0043029)2.98734156
89regulation of granulocyte differentiation (GO:0030852)2.97766705
90negative regulation of adaptive immune response (GO:0002820)2.96888141
91positive regulation of isotype switching (GO:0045830)2.95243216
92myeloid leukocyte mediated immunity (GO:0002444)2.94604771
93alpha-beta T cell activation (GO:0046631)2.93062523
94mast cell activation (GO:0045576)2.90038823
95regulation of T cell mediated cytotoxicity (GO:0001914)2.88650574
96macrophage activation (GO:0042116)2.87075913
97alpha-beta T cell differentiation (GO:0046632)2.87020858
98negative regulation of erythrocyte differentiation (GO:0045647)2.86879550
99lymphocyte migration (GO:0072676)2.86282119
100B cell proliferation (GO:0042100)2.84581245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.56366188
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.37509152
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.47969919
4RUNX_20019798_ChIP-Seq_JUKART_Human3.94796023
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.71372493
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56700709
7MYB_26560356_Chip-Seq_TH2_Human3.51694470
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.43726232
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42284468
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.17069908
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.16957866
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.01925381
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89297541
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86751211
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.86484139
16MYB_26560356_Chip-Seq_TH1_Human2.79619756
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.70295214
18SCL_19346495_ChIP-Seq_HPC-7_Human2.63203807
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50194069
20MAF_26560356_Chip-Seq_TH1_Human2.42764538
21GATA3_27048872_Chip-Seq_THYMUS_Human2.40971514
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39371922
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25821746
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23089385
25MYC_22102868_ChIP-Seq_BL_Human2.17510518
26SPI1_23547873_ChIP-Seq_NB4_Human2.12622697
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10924411
28UTX_26944678_Chip-Seq_JUKART_Human2.07678318
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03461028
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99314722
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96747588
32SPI1_23127762_ChIP-Seq_K562_Human1.92563975
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89274346
34GATA3_26560356_Chip-Seq_TH2_Human1.86901211
35VDR_24763502_ChIP-Seq_THP-1_Human1.83634728
36MAF_26560356_Chip-Seq_TH2_Human1.76807136
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.76760390
38VDR_21846776_ChIP-Seq_THP-1_Human1.72539596
39TCF7_22412390_ChIP-Seq_EML_Mouse1.72492997
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70635484
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69423185
42VDR_24787735_ChIP-Seq_THP-1_Human1.69001202
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60399214
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56120176
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.53274288
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49467649
47PU_27001747_Chip-Seq_BMDM_Mouse1.49100241
48GATA1_22025678_ChIP-Seq_K562_Human1.42602631
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.39403837
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.39087170
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34103167
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32041817
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30416837
54KDM2B_26808549_Chip-Seq_DND41_Human1.29760683
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27113614
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26640126
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23338455
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22229846
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19711466
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.16818336
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14891714
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14124188
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11498940
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09778321
65GATA1_19941826_ChIP-Seq_K562_Human1.08354885
66SMRT_27268052_Chip-Seq_Bcells_Human1.07299038
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06386880
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02926008
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99942233
70GATA2_19941826_ChIP-Seq_K562_Human0.98669970
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97780339
72GATA3_26560356_Chip-Seq_TH1_Human0.97257230
73PRDM14_20953172_ChIP-Seq_ESCs_Human0.95530807
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94958595
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.94800306
76CIITA_25753668_ChIP-Seq_RAJI_Human0.93877598
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90191632
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89968256
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88853510
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88529398
81GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84808662
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81683809
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81080419
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80678521
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80512038
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80506973
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78603818
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77976582
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77406532
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75865964
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75784505
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75758519
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.74520124
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74030174
95AR_21572438_ChIP-Seq_LNCaP_Human0.73900284
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71951623
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71905943
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71244660
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70698765
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70250572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.77539101
2MP0001835_abnormal_antigen_presentation3.70888071
3MP0000569_abnormal_digit_pigmentation3.67164111
4MP0003724_increased_susceptibility_to3.47647903
5MP0005671_abnormal_response_to3.42293675
6MP0001800_abnormal_humoral_immune3.33088900
7MP0003436_decreased_susceptibility_to3.08678216
8MP0000685_abnormal_immune_system2.80432484
9MP0002723_abnormal_immune_serum2.60519637
10MP0004381_abnormal_hair_follicle2.60218024
11MP0005000_abnormal_immune_tolerance2.58520497
12MP0002420_abnormal_adaptive_immunity2.58349615
13MP0001819_abnormal_immune_cell2.55114159
14MP0002452_abnormal_antigen_presenting2.48515471
15MP0005387_immune_system_phenotype2.47644794
16MP0001790_abnormal_immune_system2.47644794
17MP0008260_abnormal_autophagy2.47012955
18MP0005025_abnormal_response_to2.39866236
19MP0000703_abnormal_thymus_morphology2.38065942
20MP0003300_gastrointestinal_ulcer2.36796860
21MP0002398_abnormal_bone_marrow2.36720800
22MP0003303_peritoneal_inflammation2.35944642
23MP0002419_abnormal_innate_immunity2.27352596
24MP0009785_altered_susceptibility_to2.24939161
25MP0009333_abnormal_splenocyte_physiolog2.22942855
26MP0000716_abnormal_immune_system2.16994343
27MP0003866_abnormal_defecation2.15591626
28MP0002166_altered_tumor_susceptibility2.14628397
29MP0002405_respiratory_system_inflammati2.13119172
30MP0002396_abnormal_hematopoietic_system2.11561921
31MP0000689_abnormal_spleen_morphology2.01995261
32MP0006082_CNS_inflammation1.98478169
33MP0002722_abnormal_immune_system1.97322111
34MP0008057_abnormal_DNA_replication1.87371686
35MP0005464_abnormal_platelet_physiology1.81026473
36MP0005075_abnormal_melanosome_morpholog1.74399570
37MP0002429_abnormal_blood_cell1.70120816
38MP0003172_abnormal_lysosome_physiology1.69137092
39MP0010155_abnormal_intestine_physiology1.66116081
40MP0005310_abnormal_salivary_gland1.60648384
41MP0004947_skin_inflammation1.55103064
42MP0002006_tumorigenesis1.53349360
43MP0000015_abnormal_ear_pigmentation1.52723966
44MP0005451_abnormal_body_composition1.50480061
45MP0002148_abnormal_hypersensitivity_rea1.49947173
46MP0001845_abnormal_inflammatory_respons1.48689897
47MP0003787_abnormal_imprinting1.47097639
48MP0001851_eye_inflammation1.46879187
49MP0004883_abnormal_blood_vessel1.43863092
50MP0000858_altered_metastatic_potential1.37125986
51MP0001873_stomach_inflammation1.35834924
52MP0003828_pulmonary_edema1.34284495
53MP0000465_gastrointestinal_hemorrhage1.31722574
54MP0002009_preneoplasia1.27149926
55MP0004808_abnormal_hematopoietic_stem1.22050625
56MP0001533_abnormal_skeleton_physiology1.21607564
57MP0003656_abnormal_erythrocyte_physiolo1.17201978
58MP0004130_abnormal_muscle_cell1.09967678
59MP0002132_abnormal_respiratory_system1.08765737
60MP0003221_abnormal_cardiomyocyte_apopto1.07139890
61MP0005174_abnormal_tail_pigmentation1.06111438
62MP0003690_abnormal_glial_cell1.04185966
63MP0008469_abnormal_protein_level1.03025817
64MP0003183_abnormal_peptide_metabolism1.02332688
65MP0001853_heart_inflammation0.99499722
66MP0002277_abnormal_respiratory_mucosa0.98939134
67MP0002998_abnormal_bone_remodeling0.94601159
68MP0002933_joint_inflammation0.93322045
69MP0005164_abnormal_response_to0.91553574
70MP0002019_abnormal_tumor_incidence0.91308817
71MP0001545_abnormal_hematopoietic_system0.88501775
72MP0005397_hematopoietic_system_phenotyp0.88501775
73MP0009764_decreased_sensitivity_to0.87340408
74MP0003091_abnormal_cell_migration0.86454754
75MP0008877_abnormal_DNA_methylation0.83725105
76MP0009763_increased_sensitivity_to0.80112296
77MP0001663_abnormal_digestive_system0.78274708
78MP0009278_abnormal_bone_marrow0.76468133
79MP0003448_altered_tumor_morphology0.74075261
80MP0002332_abnormal_exercise_endurance0.73723692
81MP0000371_diluted_coat_color0.71144663
82MP0004484_altered_response_of0.70939209
83MP0009765_abnormal_xenobiotic_induced0.69892597
84MP0008961_abnormal_basal_metabolism0.69678916
85MP0003045_fibrosis0.69302671
86MP0001958_emphysema0.62893130
87MP0000604_amyloidosis0.58176324
88MP0000249_abnormal_blood_vessel0.54686779
89MP0000427_abnormal_hair_cycle0.52958596
90MP0008874_decreased_physiological_sensi0.51744017
91MP0000490_abnormal_crypts_of0.51355019
92MP0005376_homeostasis/metabolism_phenot0.50847915
93MP0003191_abnormal_cellular_cholesterol0.50242947
94MP0002163_abnormal_gland_morphology0.49183552
95MP0002693_abnormal_pancreas_physiology0.48872140
96MP0009115_abnormal_fat_cell0.48564012
97MP0004185_abnormal_adipocyte_glucose0.48428948
98MP0005408_hypopigmentation0.47713509
99MP0005621_abnormal_cell_physiology0.47222202
100MP0002138_abnormal_hepatobiliary_system0.47050021

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.70247231
2Abnormality of T cell number (HP:0011839)6.11064284
3Recurrent bacterial skin infections (HP:0005406)5.44407962
4Eczematoid dermatitis (HP:0000976)5.38617764
5Recurrent abscess formation (HP:0002722)4.77452404
6Recurrent fungal infections (HP:0002841)4.64469897
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.53461253
8Abnormality of T cells (HP:0002843)4.36339993
9Myositis (HP:0100614)4.21643881
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.17400531
11Recurrent viral infections (HP:0004429)4.16454415
12Gastrointestinal infarctions (HP:0005244)4.15457956
13Elevated erythrocyte sedimentation rate (HP:0003565)3.99870900
14Retrobulbar optic neuritis (HP:0100654)3.97297363
15Optic neuritis (HP:0100653)3.97297363
16Abnormality of the fingertips (HP:0001211)3.96738882
17Stomatitis (HP:0010280)3.94652277
18Panhypogammaglobulinemia (HP:0003139)3.78265851
19Chronic mucocutaneous candidiasis (HP:0002728)3.75532327
20Recurrent cutaneous fungal infections (HP:0011370)3.75532327
21Spontaneous hematomas (HP:0007420)3.72550634
22Orchitis (HP:0100796)3.70608099
23Recurrent skin infections (HP:0001581)3.68921967
24Pustule (HP:0200039)3.64184147
25Autoimmune hemolytic anemia (HP:0001890)3.58158983
26Recurrent bronchitis (HP:0002837)3.57877326
27Meningitis (HP:0001287)3.34439089
28Neonatal hypoglycemia (HP:0001998)3.32816805
29Encephalitis (HP:0002383)3.30678810
30Severe combined immunodeficiency (HP:0004430)3.30132660
31Leukocytosis (HP:0001974)3.19033883
32Abnormality of macrophages (HP:0004311)3.16846552
33Mediastinal lymphadenopathy (HP:0100721)3.15195970
34Vasculitis (HP:0002633)3.10825382
35Gingivitis (HP:0000230)3.07546418
36Lymphopenia (HP:0001888)3.00838743
37Slow saccadic eye movements (HP:0000514)2.99959075
38Recurrent gram-negative bacterial infections (HP:0005420)2.96386589
39Colitis (HP:0002583)2.95172825
40Gingival bleeding (HP:0000225)2.94520603
41Inflammation of the large intestine (HP:0002037)2.94489618
42Keratoconjunctivitis sicca (HP:0001097)2.89597027
43Hypoplasia of the thymus (HP:0000778)2.87133470
44Granulocytopenia (HP:0001913)2.85858794
45Abnormality of eosinophils (HP:0001879)2.83154003
46IgM deficiency (HP:0002850)2.82822857
47Chest pain (HP:0100749)2.82299800
48Gastrointestinal inflammation (HP:0004386)2.81952283
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.81306169
50Eosinophilia (HP:0001880)2.81213110
51Papilloma (HP:0012740)2.77477718
52Verrucae (HP:0200043)2.77477718
53Prolonged bleeding time (HP:0003010)2.76457977
54Acute hepatic failure (HP:0006554)2.76305690
55Abnormality of T cell physiology (HP:0011840)2.75306456
56IgG deficiency (HP:0004315)2.73164100
57Papilledema (HP:0001085)2.69963122
58Abnormality of the columella (HP:0009929)2.69643241
59Arterial thrombosis (HP:0004420)2.66373301
60Keratoconjunctivitis (HP:0001096)2.65787416
61Epistaxis (HP:0000421)2.62247950
62Combined immunodeficiency (HP:0005387)2.57670393
63Hemoptysis (HP:0002105)2.53749532
64Chronic obstructive pulmonary disease (HP:0006510)2.49821151
65Obstructive lung disease (HP:0006536)2.49821151
66Pulmonary infiltrates (HP:0002113)2.49646939
67Subacute progressive viral hepatitis (HP:0006572)2.47253799
68IgA deficiency (HP:0002720)2.43666333
69Viral hepatitis (HP:0006562)2.40272382
70Agammaglobulinemia (HP:0004432)2.38044713
71Thyroiditis (HP:0100646)2.31831638
72Chronic diarrhea (HP:0002028)2.28763123
73Autoimmune thrombocytopenia (HP:0001973)2.28651422
74Pulmonary embolism (HP:0002204)2.28170497
75Basal cell carcinoma (HP:0002671)2.27473794
76Cellulitis (HP:0100658)2.25520626
77Peritonitis (HP:0002586)2.23945253
78Glucose intolerance (HP:0000833)2.19215624
79Lip pit (HP:0100267)2.16790817
80Increased IgM level (HP:0003496)2.14966480
81Bronchitis (HP:0012387)2.12964670
82Hypochromic microcytic anemia (HP:0004840)2.12499721
83Hemiplegia (HP:0002301)2.12216835
84Conjunctival telangiectasia (HP:0000524)2.07868238
85Increased IgE level (HP:0003212)2.07624847
86Hypochromic anemia (HP:0001931)2.07465959
87Anorexia (HP:0002039)2.07301052
88Hematochezia (HP:0002573)2.06718486
89Periodontitis (HP:0000704)2.05658334
90Microcytic anemia (HP:0001935)2.05650792
91Aplasia/Hypoplasia of the thymus (HP:0010515)2.03500021
92Lymphoma (HP:0002665)1.99565104
93Urticaria (HP:0001025)1.99467125
94Abnormality of the peritoneum (HP:0002585)1.94115652
95Chronic otitis media (HP:0000389)1.93087323
96Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92340701
97Nasal polyposis (HP:0100582)1.88988327
98Osteomyelitis (HP:0002754)1.88068680
99Sepsis (HP:0100806)1.86957293
100Joint swelling (HP:0001386)1.85363255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.21539372
2RIPK43.28639075
3TXK3.16871133
4TAOK33.04360001
5PRPF4B2.69154971
6TYK22.56437598
7BLK2.53367266
8IKBKE2.43502425
9GRK62.37808007
10JAK32.31822417
11FES2.18759821
12CSK2.17874363
13JAK12.11781282
14ITK2.04320821
15MAP2K32.02267623
16BTK2.01521412
17IRAK41.95408739
18ZAP701.87764786
19SYK1.83184021
20FGFR31.81573171
21FGFR41.72686668
22TEC1.67931924
23CAMKK21.67266436
24MAP3K141.61969836
25MAP3K131.61581608
26MAP3K101.58677885
27PIK3CG1.55874160
28NLK1.53669820
29TNK21.45793553
30HCK1.43426381
31FGR1.43160463
32LCK1.41144630
33CDK121.39240423
34MARK31.31746040
35STK381.29038246
36WNK11.22036964
37STK41.17259870
38LYN1.16109854
39PIM11.08253350
40SGK21.08167938
41MARK21.05538126
42JAK21.05507521
43STK101.05351797
44EPHB11.02887097
45CAMKK10.99582419
46MELK0.98650546
47MAP3K30.94114831
48TBK10.89734912
49BMPR20.88766105
50MAP3K20.85827912
51PTK2B0.84011719
52SGK30.83699824
53IKBKB0.83615682
54PRKCQ0.82728031
55CDK40.82198441
56IRAK10.81005482
57YES10.80622006
58PDK10.80391237
59TYRO30.80292968
60HIPK20.77189183
61MAP3K10.72186455
62GRK50.71793746
63MAPK120.70224775
64PDGFRB0.69067192
65CSF1R0.68190758
66KIT0.68114866
67MAP3K70.66366603
68LRRK20.62583502
69IRAK20.62535765
70TAOK10.62215184
71TGFBR20.60917314
72CDK60.60506185
73TESK10.58993179
74MAPK110.58977903
75MAPK70.58843813
76SIK20.58806756
77STK110.58188640
78CAMK40.58050220
79PASK0.57912570
80SIK30.56364462
81TRPM70.55571412
82RET0.54330154
83CDC42BPA0.54013959
84SGK2230.52837016
85SGK4940.52837016
86BRD40.52775930
87FGFR20.52408998
88KSR20.47227242
89TTN0.46841056
90NEK60.46398795
91GRK70.41189185
92RAF10.41167626
93SGK10.40835299
94FYN0.40007670
95PTK60.39866928
96PRKCH0.38266846
97EGFR0.37547926
98NEK90.36536445
99FRK0.35475044
100NUAK10.33722869

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.29843240
2T cell receptor signaling pathway_Homo sapiens_hsa046602.79470409
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.62155486
4B cell receptor signaling pathway_Homo sapiens_hsa046622.46359587
5Measles_Homo sapiens_hsa051622.31171180
6Osteoclast differentiation_Homo sapiens_hsa043802.29367906
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.27059296
8Leishmaniasis_Homo sapiens_hsa051402.23680707
9Graft-versus-host disease_Homo sapiens_hsa053322.22091061
10Allograft rejection_Homo sapiens_hsa053302.09853460
11Autoimmune thyroid disease_Homo sapiens_hsa053202.06236591
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92235177
13Non-small cell lung cancer_Homo sapiens_hsa052231.90382957
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88011092
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82462641
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76889129
17Acute myeloid leukemia_Homo sapiens_hsa052211.74673378
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.71731357
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67650299
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66159895
21Chemokine signaling pathway_Homo sapiens_hsa040621.55137057
22Type I diabetes mellitus_Homo sapiens_hsa049401.51871322
23Hematopoietic cell lineage_Homo sapiens_hsa046401.51237490
24Tuberculosis_Homo sapiens_hsa051521.50104454
25Herpes simplex infection_Homo sapiens_hsa051681.49905786
26Influenza A_Homo sapiens_hsa051641.47458638
27Hepatitis B_Homo sapiens_hsa051611.47050996
28Toxoplasmosis_Homo sapiens_hsa051451.46535312
29Antigen processing and presentation_Homo sapiens_hsa046121.42080404
30TNF signaling pathway_Homo sapiens_hsa046681.35860013
31Staphylococcus aureus infection_Homo sapiens_hsa051501.35638464
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.35188465
33Pancreatic cancer_Homo sapiens_hsa052121.33329688
34Malaria_Homo sapiens_hsa051441.33155273
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32731279
36Viral myocarditis_Homo sapiens_hsa054161.26580977
37Platelet activation_Homo sapiens_hsa046111.26224887
38Dorso-ventral axis formation_Homo sapiens_hsa043201.23005213
39Chronic myeloid leukemia_Homo sapiens_hsa052201.22668662
40Prolactin signaling pathway_Homo sapiens_hsa049171.20889062
41Apoptosis_Homo sapiens_hsa042101.18789248
42FoxO signaling pathway_Homo sapiens_hsa040681.18522563
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15633337
44VEGF signaling pathway_Homo sapiens_hsa043701.12048099
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11353602
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.11117386
47Inositol phosphate metabolism_Homo sapiens_hsa005621.09403976
48Hepatitis C_Homo sapiens_hsa051601.06974457
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06694493
50Colorectal cancer_Homo sapiens_hsa052101.05161781
51Endometrial cancer_Homo sapiens_hsa052131.02128819
52Renal cell carcinoma_Homo sapiens_hsa052110.99557734
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.98185097
54Legionellosis_Homo sapiens_hsa051340.95597669
55Viral carcinogenesis_Homo sapiens_hsa052030.91427197
56mTOR signaling pathway_Homo sapiens_hsa041500.91007019
57Epstein-Barr virus infection_Homo sapiens_hsa051690.90339426
58HTLV-I infection_Homo sapiens_hsa051660.86739271
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79404724
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78775716
61Prostate cancer_Homo sapiens_hsa052150.75290129
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75193446
63Choline metabolism in cancer_Homo sapiens_hsa052310.74991793
64Glioma_Homo sapiens_hsa052140.67395812
65ErbB signaling pathway_Homo sapiens_hsa040120.66719415
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66637997
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66136426
68Asthma_Homo sapiens_hsa053100.65784613
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.65366780
70MAPK signaling pathway_Homo sapiens_hsa040100.63655461
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.60972957
72Long-term potentiation_Homo sapiens_hsa047200.60810419
73GnRH signaling pathway_Homo sapiens_hsa049120.59159912
74African trypanosomiasis_Homo sapiens_hsa051430.57037702
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56273033
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55089202
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55044464
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54586267
79Insulin resistance_Homo sapiens_hsa049310.54573407
80HIF-1 signaling pathway_Homo sapiens_hsa040660.54515691
81Type II diabetes mellitus_Homo sapiens_hsa049300.52719411
82Notch signaling pathway_Homo sapiens_hsa043300.52292194
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49930245
84Thyroid cancer_Homo sapiens_hsa052160.49682542
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48758214
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.48428992
87Phagosome_Homo sapiens_hsa041450.48067381
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47148098
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46107897
90Small cell lung cancer_Homo sapiens_hsa052220.44725567
91Ras signaling pathway_Homo sapiens_hsa040140.44558645
92Circadian rhythm_Homo sapiens_hsa047100.43527816
93Endocytosis_Homo sapiens_hsa041440.43247575
94Cholinergic synapse_Homo sapiens_hsa047250.42260677
95Shigellosis_Homo sapiens_hsa051310.40904903
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40734632
97Estrogen signaling pathway_Homo sapiens_hsa049150.39865996
98Pertussis_Homo sapiens_hsa051330.38170053
99Rheumatoid arthritis_Homo sapiens_hsa053230.37850380
100Salmonella infection_Homo sapiens_hsa051320.35363281

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