ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.52324656
2	L-fucose catabolic process (GO:0042355)	4.54373747
3	fucose catabolic process (GO:0019317)	4.54373747
4	L-fucose metabolic process (GO:0042354)	4.54373747
5	nucleotide transmembrane transport (GO:1901679)	4.52277186
6	maturation of 5.8S rRNA (GO:0000460)	4.19880761
7	DNA deamination (GO:0045006)	4.16432628
8	kynurenine metabolic process (GO:0070189)	4.09841682
9	indolalkylamine metabolic process (GO:0006586)	3.99293687
10	indole-containing compound catabolic process (GO:0042436)	3.90793127
11	indolalkylamine catabolic process (GO:0046218)	3.90793127
12	tryptophan catabolic process (GO:0006569)	3.90793127
13	negative regulation of multicellular organism growth (GO:0040015)	3.86018828
14	tryptophan metabolic process (GO:0006568)	3.84722433
15	protein import into peroxisome matrix (GO:0016558)	3.83246384
16	platelet dense granule organization (GO:0060155)	3.71794332
17	negative regulation of telomere maintenance (GO:0032205)	3.66995805
18	protein-cofactor linkage (GO:0018065)	3.62040112
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50172629
20	negative regulation of mast cell activation (GO:0033004)	3.49062448
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.33932281
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.31010731
23	ATP synthesis coupled proton transport (GO:0015986)	3.31010731
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.27914021
25	nephron tubule morphogenesis (GO:0072078)	3.19055043
26	nephron epithelium morphogenesis (GO:0072088)	3.19055043
27	response to pheromone (GO:0019236)	3.13630031
28	somite development (GO:0061053)	3.09025095
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.07927447
30	axoneme assembly (GO:0035082)	3.07764379
31	glycerophospholipid catabolic process (GO:0046475)	3.07339594
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.06190143
33	epithelial cilium movement (GO:0003351)	3.01548098
34	regulation of cilium movement (GO:0003352)	3.00835638
35	indole-containing compound metabolic process (GO:0042430)	2.97640834
36	gamma-aminobutyric acid transport (GO:0015812)	2.93804239
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.92578091
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.92578091
39	NADH dehydrogenase complex assembly (GO:0010257)	2.92578091
40	adaptation of signaling pathway (GO:0023058)	2.89582000
41	regulation of action potential (GO:0098900)	2.89220287
42	sulfation (GO:0051923)	2.87455125
43	protein deneddylation (GO:0000338)	2.87442754
44	protein complex biogenesis (GO:0070271)	2.87209347
45	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.85686662
46	cullin deneddylation (GO:0010388)	2.85241568
47	neuronal action potential (GO:0019228)	2.85169221
48	nucleoside transmembrane transport (GO:1901642)	2.83611658
49	primary amino compound metabolic process (GO:1901160)	2.83256183
50	organic cation transport (GO:0015695)	2.82816093
51	rRNA catabolic process (GO:0016075)	2.75652264
52	detection of light stimulus involved in sensory perception (GO:0050962)	2.75037725
53	detection of light stimulus involved in visual perception (GO:0050908)	2.75037725
54	negative regulation of protein oligomerization (GO:0032460)	2.73429491
55	amine catabolic process (GO:0009310)	2.71794946
56	cellular biogenic amine catabolic process (GO:0042402)	2.71794946
57	pyrimidine nucleobase catabolic process (GO:0006208)	2.71140794
58	retinal cone cell development (GO:0046549)	2.61896596
59	piRNA metabolic process (GO:0034587)	2.61820820
60	intracellular protein transmembrane import (GO:0044743)	2.61256192
61	regulation of microtubule-based movement (GO:0060632)	2.60998494
62	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.59474434
63	protein K6-linked ubiquitination (GO:0085020)	2.58620813
64	cytidine deamination (GO:0009972)	2.58077541
65	cytidine metabolic process (GO:0046087)	2.58077541
66	cytidine catabolic process (GO:0006216)	2.58077541
67	protein polyglutamylation (GO:0018095)	2.57562671
68	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.57430406
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.57430406
70	negative regulation of systemic arterial blood pressure (GO:0003085)	2.57316503
71	cilium movement (GO:0003341)	2.56297033
72	cilium morphogenesis (GO:0060271)	2.55030592
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53833140
74	synaptic transmission, cholinergic (GO:0007271)	2.52773202
75	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.51271361
76	spinal cord motor neuron differentiation (GO:0021522)	2.49587610
77	exogenous drug catabolic process (GO:0042738)	2.46962599
78	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.46537370
79	positive regulation of T-helper 1 type immune response (GO:0002827)	2.45205199
80	synapsis (GO:0007129)	2.44198244
81	cellular ketone body metabolic process (GO:0046950)	2.43755459
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.43420420
83	regulation of isotype switching to IgG isotypes (GO:0048302)	2.42699857
84	respiratory chain complex IV assembly (GO:0008535)	2.41720904
85	neuron fate determination (GO:0048664)	2.41228655
86	nonmotile primary cilium assembly (GO:0035058)	2.40900193
87	reflex (GO:0060004)	2.40661248
88	protein neddylation (GO:0045116)	2.40165369
89	cell proliferation in forebrain (GO:0021846)	2.38932194
90	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.38846338
91	positive regulation of gastrulation (GO:2000543)	2.38772775
92	male meiosis I (GO:0007141)	2.38193776
93	nucleobase catabolic process (GO:0046113)	2.37049710
94	adult feeding behavior (GO:0008343)	2.36385729
95	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.36317899
96	negative regulation of T cell differentiation in thymus (GO:0033085)	2.36288209
97	renal tubule morphogenesis (GO:0061333)	2.36078812
98	photoreceptor cell development (GO:0042461)	2.35867507
99	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.34845373
100	regulation of telomere maintenance (GO:0032204)	2.33902131

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75910253
2	VDR_22108803_ChIP-Seq_LS180_Human	3.46924719
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.07477252
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.03897346
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.94352627
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83121982
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37687547
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19235607
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11149208
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10282093
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08616228
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06874189
13	EWS_26573619_Chip-Seq_HEK293_Human	2.02641381
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94756065
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93274516
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92864876
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.90051146
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89727320
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85158295
20	P300_19829295_ChIP-Seq_ESCs_Human	1.82130182
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.81405187
22	FUS_26573619_Chip-Seq_HEK293_Human	1.74326868
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71470379
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70903513
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69556066
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64036525
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.63068157
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.62358167
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62226218
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.59706557
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.48428503
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47533929
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46340532
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46340532
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43119811
36	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42747722
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42066929
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41378978
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41182817
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41182817
41	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39151896
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.37873674
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.37654132
44	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.35962218
45	STAT3_23295773_ChIP-Seq_U87_Human	1.32958070
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32954608
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32867806
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30968091
49	AR_25329375_ChIP-Seq_VCAP_Human	1.29566611
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27683173
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26212828
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25789402
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25310375
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25288124
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23441198
56	AR_20517297_ChIP-Seq_VCAP_Human	1.22874414
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22758497
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.21870838
59	TCF4_23295773_ChIP-Seq_U87_Human	1.21662893
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21283786
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.19581563
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19581563
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.19518308
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19476332
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17680428
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17320729
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17226762
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16966692
69	NCOR_22424771_ChIP-Seq_293T_Human	1.16348185
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16144684
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15437385
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14756936
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13873874
74	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13186535
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12888164
76	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.12442218
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11734240
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10433561
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10399176
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10306997
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09462271
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08655599
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08046582
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07680735
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06829865
86	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.05314113
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04746996
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03819054
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03819054
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03063257
91	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.02949904
92	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02321621
93	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02170316
94	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.01725549
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01348546
96	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00720588
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00702996
98	MYC_19829295_ChIP-Seq_ESCs_Human	1.00660815
99	TP53_16413492_ChIP-PET_HCT116_Human	1.00640375
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99687644

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002876_abnormal_thyroid_physiology	2.85210880
2	MP0002653_abnormal_ependyma_morphology	2.62910433
3	MP0005551_abnormal_eye_electrophysiolog	2.44070645
4	MP0002837_dystrophic_cardiac_calcinosis	2.40116531
5	MP0000569_abnormal_digit_pigmentation	2.31732167
6	MP0008877_abnormal_DNA_methylation	2.22715508
7	MP0001968_abnormal_touch/_nociception	2.12874709
8	MP0006292_abnormal_olfactory_placode	2.12599301
9	MP0008872_abnormal_physiological_respon	2.12472084
10	MP0003195_calcinosis	2.07744264
11	MP0006072_abnormal_retinal_apoptosis	1.96774033
12	MP0005646_abnormal_pituitary_gland	1.95130887
13	MP0002736_abnormal_nociception_after	1.94294499
14	MP0004885_abnormal_endolymph	1.89671000
15	MP0008875_abnormal_xenobiotic_pharmacok	1.89444799
16	MP0002102_abnormal_ear_morphology	1.88160554
17	MP0003011_delayed_dark_adaptation	1.86566069
18	MP0005084_abnormal_gallbladder_morpholo	1.85446351
19	MP0002938_white_spotting	1.85413497
20	MP0004142_abnormal_muscle_tone	1.81788048
21	MP0001485_abnormal_pinna_reflex	1.81439187
22	MP0009046_muscle_twitch	1.78946576
23	MP0002272_abnormal_nervous_system	1.77802505
24	MP0002254_reproductive_system_inflammat	1.76314369
25	MP0004133_heterotaxia	1.74892523
26	MP0009745_abnormal_behavioral_response	1.74553170
27	MP0003787_abnormal_imprinting	1.72476166
28	MP0003136_yellow_coat_color	1.69868788
29	MP0005253_abnormal_eye_physiology	1.58481457
30	MP0001501_abnormal_sleep_pattern	1.57599280
31	MP0001986_abnormal_taste_sensitivity	1.56571844
32	MP0003880_abnormal_central_pattern	1.55663540
33	MP0000372_irregular_coat_pigmentation	1.54230296
34	MP0009379_abnormal_foot_pigmentation	1.52674805
35	MP0001486_abnormal_startle_reflex	1.52454279
36	MP0006276_abnormal_autonomic_nervous	1.50190253
37	MP0000631_abnormal_neuroendocrine_gland	1.49637290
38	MP0001984_abnormal_olfaction	1.47228487
39	MP0001529_abnormal_vocalization	1.41132467
40	MP0002928_abnormal_bile_duct	1.39018970
41	MP0005171_absent_coat_pigmentation	1.38466505
42	MP0002638_abnormal_pupillary_reflex	1.35752362
43	MP0002277_abnormal_respiratory_mucosa	1.34088326
44	MP0003878_abnormal_ear_physiology	1.31993168
45	MP0005377_hearing/vestibular/ear_phenot	1.31993168
46	MP0001873_stomach_inflammation	1.31700944
47	MP0003646_muscle_fatigue	1.28256507
48	MP0000427_abnormal_hair_cycle	1.24166939
49	MP0002064_seizures	1.24103738
50	MP0005389_reproductive_system_phenotype	1.22573117
51	MP0002557_abnormal_social/conspecific_i	1.20582439
52	MP0002572_abnormal_emotion/affect_behav	1.19978340
53	MP0002138_abnormal_hepatobiliary_system	1.19840195
54	MP0005645_abnormal_hypothalamus_physiol	1.19725570
55	MP0004742_abnormal_vestibular_system	1.19676305
56	MP0006082_CNS_inflammation	1.17570645
57	MP0002160_abnormal_reproductive_system	1.15077136
58	MP0005174_abnormal_tail_pigmentation	1.10964311
59	MP0004043_abnormal_pH_regulation	1.10113215
60	MP0002095_abnormal_skin_pigmentation	1.07607177
61	MP0001905_abnormal_dopamine_level	1.06881954
62	MP0005195_abnormal_posterior_eye	1.06618436
63	MP0003137_abnormal_impulse_conducting	1.06149818
64	MP0001440_abnormal_grooming_behavior	1.03728862
65	MP0004145_abnormal_muscle_electrophysio	1.03614077
66	MP0010386_abnormal_urinary_bladder	1.02888781
67	MP0002067_abnormal_sensory_capabilities	1.02533516
68	MP0002163_abnormal_gland_morphology	1.02524223
69	MP0004924_abnormal_behavior	1.01951761
70	MP0005386_behavior/neurological_phenoty	1.01951761
71	MP0005671_abnormal_response_to	1.00977844
72	MP0001919_abnormal_reproductive_system	1.00864853
73	MP0003635_abnormal_synaptic_transmissio	0.97870272
74	MP0002063_abnormal_learning/memory/cond	0.97703590
75	MP0001970_abnormal_pain_threshold	0.97605230
76	MP0002751_abnormal_autonomic_nervous	0.97305382
77	MP0002733_abnormal_thermal_nociception	0.96316017
78	MP0001502_abnormal_circadian_rhythm	0.93303504
79	MP0003283_abnormal_digestive_organ	0.92593163
80	MP0002735_abnormal_chemical_nociception	0.92322521
81	MP0000026_abnormal_inner_ear	0.89221724
82	MP0005379_endocrine/exocrine_gland_phen	0.88607255
83	MP0002752_abnormal_somatic_nervous	0.86937840
84	MP0000049_abnormal_middle_ear	0.85766892
85	MP0004782_abnormal_surfactant_physiolog	0.84586542
86	MP0005075_abnormal_melanosome_morpholog	0.84502976
87	MP0000538_abnormal_urinary_bladder	0.83855958
88	MP0009764_decreased_sensitivity_to	0.83558126
89	MP0001963_abnormal_hearing_physiology	0.81785275
90	MP0003122_maternal_imprinting	0.81714561
91	MP0001293_anophthalmia	0.81235402
92	MP0002693_abnormal_pancreas_physiology	0.80763941
93	MP0005503_abnormal_tendon_morphology	0.78483421
94	MP0002734_abnormal_mechanical_nocicepti	0.77676328
95	MP0000778_abnormal_nervous_system	0.77218768
96	MP0005410_abnormal_fertilization	0.77151481
97	MP0002229_neurodegeneration	0.76916238
98	MP0005085_abnormal_gallbladder_physiolo	0.76862014
99	MP0002282_abnormal_trachea_morphology	0.75587598
100	MP0005360_urolithiasis	0.74486125

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.06712375
2	Molar tooth sign on MRI (HP:0002419)	3.95800683
3	Abnormality of midbrain morphology (HP:0002418)	3.95800683
4	True hermaphroditism (HP:0010459)	3.88339635
5	Type II lissencephaly (HP:0007260)	3.88256913
6	Pancreatic fibrosis (HP:0100732)	3.81343782
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.47636551
8	Absent/shortened dynein arms (HP:0200106)	3.47636551
9	Congenital stationary night blindness (HP:0007642)	3.41243653
10	Abnormality of the renal cortex (HP:0011035)	3.27710639
11	Nephronophthisis (HP:0000090)	3.25918285
12	Medial flaring of the eyebrow (HP:0010747)	3.11098289
13	Polydipsia (HP:0001959)	2.97104466
14	Abnormal drinking behavior (HP:0030082)	2.97104466
15	Pendular nystagmus (HP:0012043)	2.89910915
16	Abnormality of the renal medulla (HP:0100957)	2.86084400
17	Chronic hepatic failure (HP:0100626)	2.81037100
18	Abolished electroretinogram (ERG) (HP:0000550)	2.71092049
19	Tubular atrophy (HP:0000092)	2.70054486
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.65676731
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.65676731
22	Renal cortical cysts (HP:0000803)	2.61344216
23	Cerebellar dysplasia (HP:0007033)	2.61255227
24	Cystic liver disease (HP:0006706)	2.59307357
25	Hypothermia (HP:0002045)	2.55451992
26	Abnormal ciliary motility (HP:0012262)	2.51326589
27	Sclerocornea (HP:0000647)	2.50780505
28	Hyperventilation (HP:0002883)	2.49483050
29	Increased corneal curvature (HP:0100692)	2.48170817
30	Keratoconus (HP:0000563)	2.48170817
31	Attenuation of retinal blood vessels (HP:0007843)	2.47619974
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.40772081
33	Lissencephaly (HP:0001339)	2.39412784
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39303843
35	Abnormality of alanine metabolism (HP:0010916)	2.39303843
36	Hyperalaninemia (HP:0003348)	2.39303843
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.37609931
38	Asplenia (HP:0001746)	2.35476579
39	Stomach cancer (HP:0012126)	2.31761598
40	Inability to walk (HP:0002540)	2.30545965
41	Polyuria (HP:0000103)	2.29947255
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.28420315
43	Congenital, generalized hypertrichosis (HP:0004540)	2.24918631
44	Large for gestational age (HP:0001520)	2.22947498
45	Gait imbalance (HP:0002141)	2.20026280
46	Bilateral microphthalmos (HP:0007633)	2.18707392
47	Decreased circulating renin level (HP:0003351)	2.17549508
48	Hypoplasia of the pons (HP:0012110)	2.17325011
49	Brushfield spots (HP:0001088)	2.17043738
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13262451
51	Abnormality of the pons (HP:0007361)	2.12160608
52	Abnormal biliary tract physiology (HP:0012439)	2.10325403
53	Bile duct proliferation (HP:0001408)	2.10325403
54	Anencephaly (HP:0002323)	2.09336671
55	Congenital primary aphakia (HP:0007707)	2.08545052
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.06178258
57	Supernumerary bones of the axial skeleton (HP:0009144)	2.03090366
58	Retinal dysplasia (HP:0007973)	2.02579905
59	Gaze-evoked nystagmus (HP:0000640)	2.02546045
60	Nephrogenic diabetes insipidus (HP:0009806)	2.00815305
61	Conical tooth (HP:0000698)	2.00233985
62	3-Methylglutaconic aciduria (HP:0003535)	2.00202447
63	Abnormality of the labia minora (HP:0012880)	1.99918024
64	Congenital hepatic fibrosis (HP:0002612)	1.99822247
65	Focal motor seizures (HP:0011153)	1.99446086
66	Optic nerve coloboma (HP:0000588)	1.97287717
67	Hypomagnesemia (HP:0002917)	1.96924841
68	Male pseudohermaphroditism (HP:0000037)	1.96844272
69	Decreased central vision (HP:0007663)	1.96672227
70	Concave nail (HP:0001598)	1.94938600
71	Mitochondrial inheritance (HP:0001427)	1.93914657
72	Furrowed tongue (HP:0000221)	1.92805442
73	Stomatitis (HP:0010280)	1.91820573
74	Progressive inability to walk (HP:0002505)	1.91536116
75	Broad-based gait (HP:0002136)	1.89504668
76	Increased CSF lactate (HP:0002490)	1.88784976
77	Limb dystonia (HP:0002451)	1.88442399
78	Abnormal urine output (HP:0012590)	1.85704273
79	Tachypnea (HP:0002789)	1.85239148
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84887403
81	Severe muscular hypotonia (HP:0006829)	1.83061803
82	Optic nerve hypoplasia (HP:0000609)	1.81911056
83	Disproportionate short-trunk short stature (HP:0003521)	1.80795074
84	Pachygyria (HP:0001302)	1.80631562
85	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80248562
86	Progressive cerebellar ataxia (HP:0002073)	1.79335616
87	Chorioretinal atrophy (HP:0000533)	1.78459883
88	Abnormality of macular pigmentation (HP:0008002)	1.78326228
89	Hemiparesis (HP:0001269)	1.77343347
90	Methylmalonic acidemia (HP:0002912)	1.76907035
91	Abnormality of the renal collecting system (HP:0004742)	1.75932128
92	Genital tract atresia (HP:0001827)	1.74768239
93	Anophthalmia (HP:0000528)	1.73670456
94	Postaxial foot polydactyly (HP:0001830)	1.71993328
95	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71924889
96	Acute necrotizing encephalopathy (HP:0006965)	1.71467304
97	Protruding tongue (HP:0010808)	1.70347636
98	Abnormal albumin level (HP:0012116)	1.69429923
99	Hypoalbuminemia (HP:0003073)	1.69429923
100	Febrile seizures (HP:0002373)	1.69249419

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.97268224
2	TLK1	3.96082264
3	ADRBK2	3.51781687
4	ZAK	2.64506469
5	TAOK3	2.60476015
6	BMPR1B	2.60269526
7	NUAK1	2.60020021
8	WNK4	2.48148033
9	MAP4K2	2.42570286
10	GRK1	2.39872736
11	WNK3	2.39386997
12	TXK	2.03562719
13	MAPK15	2.00639996
14	CASK	1.83476209
15	VRK1	1.79962624
16	PNCK	1.63261751
17	INSRR	1.62839867
18	MAPK13	1.61895491
19	BRSK2	1.58830489
20	MAP3K4	1.57244229
21	PINK1	1.55816592
22	TSSK6	1.53684632
23	PASK	1.41414686
24	DAPK2	1.40916166
25	OXSR1	1.39272954
26	ACVR1B	1.28919667
27	TIE1	1.27152735
28	STK39	1.24862182
29	PKN1	1.20897563
30	PAK3	1.19750180
31	MKNK2	1.17126427
32	IKBKB	1.16951046
33	DYRK2	1.16596112
34	TNIK	1.09057462
35	RPS6KA5	1.08676036
36	PRKCG	1.02186306
37	EPHA3	1.00365400
38	PHKG2	0.97552339
39	PHKG1	0.97552339
40	VRK2	0.97530200
41	PIK3CA	0.95682606
42	ADRBK1	0.94698318
43	NTRK2	0.91884659
44	MAPKAPK5	0.86845311
45	PRKCE	0.84459454
46	TGFBR1	0.79380297
47	PRKCI	0.79132638
48	PTK2B	0.78344184
49	MARK1	0.77742468
50	WEE1	0.76300337
51	PRKCQ	0.75253726
52	CSNK1G1	0.75087790
53	CSNK1G2	0.74280011
54	MUSK	0.72790286
55	MAP2K2	0.70713838
56	TEC	0.68062280
57	EPHA4	0.65801979
58	TRIM28	0.61527903
59	ITK	0.61459158
60	PLK3	0.61397924
61	IRAK1	0.61302818
62	CSNK1G3	0.60646760
63	STK11	0.60070442
64	CAMKK2	0.57407825
65	PRKACA	0.57304569
66	PRKCZ	0.55789935
67	MAP2K6	0.54969825
68	FGFR2	0.54083753
69	MAP2K7	0.53420093
70	MARK3	0.53246667
71	MKNK1	0.52212975
72	CAMKK1	0.49892091
73	CSNK1A1	0.46326759
74	STK38L	0.45618780
75	CHUK	0.45329277
76	CAMK2A	0.44633057
77	IKBKE	0.44173788
78	BCKDK	0.44013822
79	RPS6KA6	0.43961649
80	KIT	0.43957823
81	GRK7	0.38766201
82	PRKCA	0.37390386
83	CSNK1A1L	0.37180589
84	ERBB3	0.37107312
85	NLK	0.36780901
86	BCR	0.36666884
87	CDK3	0.35151446
88	NTRK3	0.34542528
89	OBSCN	0.34123532
90	PRKCH	0.34071699
91	SGK2	0.33023415
92	TNK2	0.31983718
93	BRSK1	0.31775806
94	NEK2	0.31467050
95	CSNK1D	0.31325792
96	CHEK2	0.31321794
97	PRKAA1	0.31142550
98	ERBB2	0.30614986
99	DYRK1A	0.27367235
100	PLK4	0.26662290

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.81061844
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.75559012
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.65998924
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.57103581
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.56543447
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.55860646
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.44725076
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.41249265
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.33688613
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.26619728
11	Caffeine metabolism_Homo sapiens_hsa00232	2.16354088
12	Nicotine addiction_Homo sapiens_hsa05033	2.14152820
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06020688
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.95093792
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.93267744
16	Parkinsons disease_Homo sapiens_hsa05012	1.86004197
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79918019
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76523015
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.66977337
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60818984
21	Protein export_Homo sapiens_hsa03060	1.60363550
22	Butanoate metabolism_Homo sapiens_hsa00650	1.59671134
23	One carbon pool by folate_Homo sapiens_hsa00670	1.50742595
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44904407
25	RNA polymerase_Homo sapiens_hsa03020	1.40958581
26	Basal transcription factors_Homo sapiens_hsa03022	1.28772024
27	Sulfur relay system_Homo sapiens_hsa04122	1.25698442
28	Ribosome_Homo sapiens_hsa03010	1.22805201
29	Huntingtons disease_Homo sapiens_hsa05016	1.21670059
30	Taste transduction_Homo sapiens_hsa04742	1.21353010
31	RNA degradation_Homo sapiens_hsa03018	1.19171690
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19146498
33	Morphine addiction_Homo sapiens_hsa05032	1.17759430
34	Alzheimers disease_Homo sapiens_hsa05010	1.16756183
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15561106
36	Peroxisome_Homo sapiens_hsa04146	1.15479626
37	Olfactory transduction_Homo sapiens_hsa04740	1.14255435
38	Homologous recombination_Homo sapiens_hsa03440	1.12937143
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12310344
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.11573390
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10589690
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10243163
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04454508
44	Retinol metabolism_Homo sapiens_hsa00830	1.03452140
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02847163
46	Asthma_Homo sapiens_hsa05310	1.02625984
47	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02565348
48	Regulation of autophagy_Homo sapiens_hsa04140	1.00147422
49	Insulin secretion_Homo sapiens_hsa04911	0.99179333
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.97829227
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.97669883
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96469090
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93265347
54	GABAergic synapse_Homo sapiens_hsa04727	0.92251557
55	Sulfur metabolism_Homo sapiens_hsa00920	0.92042295
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90173289
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89770904
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.88321800
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.88004640
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87717786
61	Allograft rejection_Homo sapiens_hsa05330	0.85358287
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82714747
63	Mineral absorption_Homo sapiens_hsa04978	0.82460461
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81182968
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80799480
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76814614
67	Circadian entrainment_Homo sapiens_hsa04713	0.76797598
68	ABC transporters_Homo sapiens_hsa02010	0.75783910
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.75003321
70	Serotonergic synapse_Homo sapiens_hsa04726	0.72542774
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70273743
72	Salivary secretion_Homo sapiens_hsa04970	0.68028352
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67166121
74	Histidine metabolism_Homo sapiens_hsa00340	0.67094504
75	Alcoholism_Homo sapiens_hsa05034	0.66757247
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65874022
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62112270
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58898381
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58385463
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57430270
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56110468
82	Cocaine addiction_Homo sapiens_hsa05030	0.51659548
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.50165897
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.49768432
85	Metabolic pathways_Homo sapiens_hsa01100	0.49615208
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47896847
87	Purine metabolism_Homo sapiens_hsa00230	0.46158078
88	Amphetamine addiction_Homo sapiens_hsa05031	0.46146782
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.46090070
90	Propanoate metabolism_Homo sapiens_hsa00640	0.45750271
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.44321304
92	Folate biosynthesis_Homo sapiens_hsa00790	0.43829497
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43817431
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43709171
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42444421
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41558318
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41100601
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39866532
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.37067933
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35925346

E2F3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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