E2F5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.52567349
2metaphase plate congression (GO:0051310)5.51588330
3protein K6-linked ubiquitination (GO:0085020)5.31696813
4mitotic chromosome condensation (GO:0007076)5.21186853
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.11343090
6regulation of meiosis I (GO:0060631)5.07271491
7regulation of meiosis (GO:0040020)5.04391346
8attachment of spindle microtubules to kinetochore (GO:0008608)4.93654857
9establishment of chromosome localization (GO:0051303)4.91556478
10meiotic chromosome segregation (GO:0045132)4.79228398
11regulation of sister chromatid cohesion (GO:0007063)4.69968506
12female gamete generation (GO:0007292)4.64251520
13regulation of exit from mitosis (GO:0007096)4.64247649
14piRNA metabolic process (GO:0034587)4.56608240
15protein localization to chromosome, centromeric region (GO:0071459)4.43719325
16DNA damage induced protein phosphorylation (GO:0006975)4.37899540
17DNA damage response, signal transduction resulting in transcription (GO:0042772)4.36912589
18chromatin remodeling at centromere (GO:0031055)4.33901815
19CENP-A containing nucleosome assembly (GO:0034080)4.31035677
20mitotic sister chromatid segregation (GO:0000070)4.29834568
21histone H2A monoubiquitination (GO:0035518)4.29010939
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.24906407
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.23068092
24protein localization to kinetochore (GO:0034501)4.22362351
25negative regulation of meiosis (GO:0045835)4.19276829
26regulation of histone H3-K27 methylation (GO:0061085)4.16629667
27monoubiquitinated protein deubiquitination (GO:0035520)4.07119965
28meiotic cell cycle (GO:0051321)4.04827597
29somatic hypermutation of immunoglobulin genes (GO:0016446)4.00180829
30somatic diversification of immune receptors via somatic mutation (GO:0002566)4.00180829
31DNA replication-independent nucleosome organization (GO:0034724)3.98402370
32DNA replication-independent nucleosome assembly (GO:0006336)3.98402370
33regulation of female gonad development (GO:2000194)3.96870595
34histone exchange (GO:0043486)3.93405897
35kinetochore assembly (GO:0051382)3.92135272
36regulation of meiotic cell cycle (GO:0051445)3.92040816
37maturation of 5.8S rRNA (GO:0000460)3.90152533
38kinetochore organization (GO:0051383)3.85241700
39protein localization to chromosome (GO:0034502)3.79187829
40regulation of spindle organization (GO:0090224)3.78408430
41chromosome segregation (GO:0007059)3.76805955
42histone H2A ubiquitination (GO:0033522)3.74008804
43mitotic sister chromatid cohesion (GO:0007064)3.71107109
44negative regulation of DNA-templated transcription, elongation (GO:0032785)3.68082745
45negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.68082745
46sister chromatid segregation (GO:0000819)3.65525953
47spindle checkpoint (GO:0031577)3.64697511
48male meiosis (GO:0007140)3.63042430
49regulation of chromosome segregation (GO:0051983)3.62516824
50DNA double-strand break processing (GO:0000729)3.61340992
51regulation of gene silencing by RNA (GO:0060966)3.59712633
52regulation of posttranscriptional gene silencing (GO:0060147)3.59712633
53regulation of gene silencing by miRNA (GO:0060964)3.59712633
54mitotic nuclear envelope disassembly (GO:0007077)3.59383218
55positive regulation of chromosome segregation (GO:0051984)3.58768395
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.58698568
57paraxial mesoderm development (GO:0048339)3.55135467
58DNA replication checkpoint (GO:0000076)3.50363410
59oocyte maturation (GO:0001556)3.49453998
60chromatin assembly or disassembly (GO:0006333)3.44398613
61positive regulation of megakaryocyte differentiation (GO:0045654)3.43267000
62negative regulation of smooth muscle cell differentiation (GO:0051151)3.42921364
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41471654
64notochord development (GO:0030903)3.38973183
65membrane disassembly (GO:0030397)3.37589474
66nuclear envelope disassembly (GO:0051081)3.37589474
67sister chromatid cohesion (GO:0007062)3.37237496
68centriole replication (GO:0007099)3.37139633
69replication fork processing (GO:0031297)3.34287643
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.33100899
71regulation of telomere maintenance via telomerase (GO:0032210)3.28043611
72mitotic spindle checkpoint (GO:0071174)3.27846766
73regulation of RIG-I signaling pathway (GO:0039535)3.26931213
74negative regulation of meiotic cell cycle (GO:0051447)3.25922170
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25421397
76negative regulation of translation, ncRNA-mediated (GO:0040033)3.25421397
77regulation of translation, ncRNA-mediated (GO:0045974)3.25421397
78regulation of retinoic acid receptor signaling pathway (GO:0048385)3.25167174
79DNA replication-dependent nucleosome organization (GO:0034723)3.24105436
80DNA replication-dependent nucleosome assembly (GO:0006335)3.24105436
81regulation of mitotic spindle organization (GO:0060236)3.23678348
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20589499
83presynaptic membrane assembly (GO:0097105)3.19683438
84folic acid-containing compound biosynthetic process (GO:0009396)3.18974430
85negative regulation of chromosome segregation (GO:0051985)3.16900214
86negative regulation of cell aging (GO:0090344)3.16047451
87protein complex localization (GO:0031503)3.15831917
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.14095131
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14095131
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14095131
91negative regulation of sister chromatid segregation (GO:0033046)3.14095131
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.13809465
93regulation of transforming growth factor beta2 production (GO:0032909)3.12534141
94regulation of DNA methylation (GO:0044030)3.12484244
95negative regulation of hormone metabolic process (GO:0032351)3.12284321
96negative regulation of hormone biosynthetic process (GO:0032353)3.12284321
97microtubule nucleation (GO:0007020)3.08165206
98regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06840484
99mitotic spindle assembly checkpoint (GO:0007094)3.06456294
100type B pancreatic cell development (GO:0003323)3.06218350
101protein K11-linked ubiquitination (GO:0070979)3.05821972
102inner cell mass cell proliferation (GO:0001833)3.05138741
103meiotic cell cycle process (GO:1903046)3.04230360
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.03356255
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.03118978
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03118978
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03118978
108negative regulation of cell division (GO:0051782)3.02565535
109regulation of centriole replication (GO:0046599)3.02535598
110negative regulation of nuclear division (GO:0051784)3.01525188
111spindle assembly checkpoint (GO:0071173)3.00622998
112gene silencing by RNA (GO:0031047)3.00331879
113regulation of sister chromatid segregation (GO:0033045)3.00109366
114regulation of mitotic sister chromatid separation (GO:0010965)3.00109366
115regulation of mitotic sister chromatid segregation (GO:0033047)3.00109366
116resolution of meiotic recombination intermediates (GO:0000712)2.96490262
117recombinational repair (GO:0000725)2.96023679
118double-strand break repair via homologous recombination (GO:0000724)2.96020651
119somatic recombination of immunoglobulin gene segments (GO:0016447)2.90987107
120pre-miRNA processing (GO:0031054)2.90806956
121limb bud formation (GO:0060174)2.90246016
122somatic diversification of immunoglobulins (GO:0016445)2.89874274
123behavioral response to nicotine (GO:0035095)2.88857701
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87817614
125regulation of mitotic spindle checkpoint (GO:1903504)2.87817614
126somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82656013
127somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82656013
128isotype switching (GO:0045190)2.82656013
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79453011
130reciprocal meiotic recombination (GO:0007131)2.78395631
131reciprocal DNA recombination (GO:0035825)2.78395631
132maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76893527
133regulation of centrosome duplication (GO:0010824)2.75031045
134presynaptic membrane organization (GO:0097090)2.74147024
135otic vesicle formation (GO:0030916)2.73280829
136synapsis (GO:0007129)2.72650011
137nuclear pore organization (GO:0006999)2.70031230
138regulation of helicase activity (GO:0051095)2.68031828
139regulation of centrosome cycle (GO:0046605)2.67686091
140cell proliferation in forebrain (GO:0021846)2.66687784
141regulation of mesoderm development (GO:2000380)2.65913780
142neural tube formation (GO:0001841)2.65053822
143DNA ligation (GO:0006266)2.63811674
144somatic diversification of immune receptors (GO:0002200)2.61964864
145regulation of DNA endoreduplication (GO:0032875)2.60895248
146somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60203255
147somatic cell DNA recombination (GO:0016444)2.60203255
148negative regulation of DNA recombination (GO:0045910)2.59496926
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59411583
150intra-S DNA damage checkpoint (GO:0031573)2.59028440
151somite development (GO:0061053)2.58579541
152fucose catabolic process (GO:0019317)2.58337502
153L-fucose metabolic process (GO:0042354)2.58337502
154L-fucose catabolic process (GO:0042355)2.58337502
155kidney morphogenesis (GO:0060993)2.57816532
156nonmotile primary cilium assembly (GO:0035058)2.55619285
157negative regulation of astrocyte differentiation (GO:0048712)2.55602508
158establishment of integrated proviral latency (GO:0075713)2.55265881
159dorsal/ventral axis specification (GO:0009950)2.54164900
160postreplication repair (GO:0006301)2.51799901
161exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48914234
162regulation of histone H3-K9 methylation (GO:0051570)2.47417635
163microtubule anchoring (GO:0034453)2.46818946
164DNA topological change (GO:0006265)2.46364014
165non-recombinational repair (GO:0000726)2.43148836
166double-strand break repair via nonhomologous end joining (GO:0006303)2.43148836
167pseudouridine synthesis (GO:0001522)2.42856361
168somite rostral/caudal axis specification (GO:0032525)2.42678463
169epithelial cilium movement (GO:0003351)2.42655328
170DNA recombination (GO:0006310)2.41386547
171histone H2A acetylation (GO:0043968)2.40962791
172regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40836317
173nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40825264
174hindbrain development (GO:0030902)2.39375359
175translesion synthesis (GO:0019985)2.38959632
176DNA catabolic process, exonucleolytic (GO:0000738)2.36968511
177DNA damage response, detection of DNA damage (GO:0042769)2.36825362
178lateral sprouting from an epithelium (GO:0060601)2.36531150
179ATP-dependent chromatin remodeling (GO:0043044)2.35678863
180centriole assembly (GO:0098534)2.33241257
181regulation of development, heterochronic (GO:0040034)2.32858807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.49441061
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.86963788
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human5.09464783
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97052697
5AR_21909140_ChIP-Seq_LNCAP_Human3.88855047
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.36227668
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98810959
8ZNF274_21170338_ChIP-Seq_K562_Hela2.95907565
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.90594727
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87080904
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.53674359
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43249504
13KAP1_22055183_ChIP-Seq_ESCs_Mouse2.43205388
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39808057
15VDR_22108803_ChIP-Seq_LS180_Human2.24968913
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16228313
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.11188914
18MYCN_18555785_ChIP-Seq_MESCs_Mouse2.11061329
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.10943745
20GBX2_23144817_ChIP-Seq_PC3_Human2.10626814
21ELK1_19687146_ChIP-ChIP_HELA_Human2.04808246
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04599139
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93899652
24P300_19829295_ChIP-Seq_ESCs_Human1.92143090
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90692206
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90460830
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89512050
28TAF15_26573619_Chip-Seq_HEK293_Human1.88834819
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.84708886
30MYC_18940864_ChIP-ChIP_HL60_Human1.84501676
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78895342
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76416287
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73592925
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73486773
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72692071
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72078246
37* TP63_19390658_ChIP-ChIP_HaCaT_Human1.68865604
38EZH2_22144423_ChIP-Seq_EOC_Human1.66191186
39SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.65167513
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63462444
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63462444
42IRF1_19129219_ChIP-ChIP_H3396_Human1.62719876
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.62575760
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56531393
45* GABP_17652178_ChIP-ChIP_JURKAT_Human1.52788708
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.52730400
47* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50339530
48* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49231117
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48872643
50ER_23166858_ChIP-Seq_MCF-7_Human1.47340093
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.46647025
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45820599
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44630586
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44556276
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.42023066
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39246089
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38767552
58XRN2_22483619_ChIP-Seq_HELA_Human1.38285627
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36761426
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36730763
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32773360
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32361552
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.32128613
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31657437
65FUS_26573619_Chip-Seq_HEK293_Human1.30883972
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30831432
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30242956
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30196880
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29271483
70* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28650685
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28012214
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26154501
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.25783509
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24375603
75GABP_19822575_ChIP-Seq_HepG2_Human1.23818682
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23621293
77RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22723822
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21981272
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21247195
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20785270
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20781076
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19921210
83* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19580956
84* CBP_20019798_ChIP-Seq_JUKART_Human1.19580956
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19490337
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.19166189
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18903496
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.18305146
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18049596
90VDR_23849224_ChIP-Seq_CD4+_Human1.16548726
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16151545
92STAT3_23295773_ChIP-Seq_U87_Human1.16050770
93DCP1A_22483619_ChIP-Seq_HELA_Human1.14516675
94KDM5A_27292631_Chip-Seq_BREAST_Human1.13241499
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13219551
96EWS_26573619_Chip-Seq_HEK293_Human1.11882390
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11403342
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10478327
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09840245
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09653005
101TCF4_23295773_ChIP-Seq_U87_Human1.08312121
102TTF2_22483619_ChIP-Seq_HELA_Human1.07509923
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.07246742
104ETS1_20019798_ChIP-Seq_JURKAT_Human1.06382322
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05214007
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05157202
107SMAD4_21799915_ChIP-Seq_A2780_Human1.04858828
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04447513
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04415705
110TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04110618
111AR_21572438_ChIP-Seq_LNCaP_Human1.04061616
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.02908121
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02422785
114TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02236257
115TCF4_22108803_ChIP-Seq_LS180_Human1.01919806
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01076253
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00898790
118AR_25329375_ChIP-Seq_VCAP_Human1.00531631
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00093244
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99958249
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99692507
122RUNX2_22187159_ChIP-Seq_PCA_Human0.99443114
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98904959
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98297919
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98055857
126* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97805611
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.97682215
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97669124
129TP53_22573176_ChIP-Seq_HFKS_Human0.96825418
130BCAT_22108803_ChIP-Seq_LS180_Human0.95672375
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95081090
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94239113
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93942880
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91224464
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88248409
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88248409
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88248409
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87151532
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87108015
140NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86968066
141KAP1_27257070_Chip-Seq_ESCs_Mouse0.85738712
142* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85070612
143HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83879168
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83463444
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83353336
146IGF1R_20145208_ChIP-Seq_DFB_Human0.82774336
147PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81894340
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80830208
149EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79979275
150FOXP3_21729870_ChIP-Seq_TREG_Human0.79789975
151PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79008270
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78226298
153RNF2_27304074_Chip-Seq_NSC_Mouse0.77865747
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76429171
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75742787
156NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75449527
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75179334
158POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74557079
159POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.73339051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.73509507
2MP0003718_maternal_effect3.98312964
3MP0004957_abnormal_blastocyst_morpholog3.69009129
4MP0005451_abnormal_body_composition3.47477351
5MP0002102_abnormal_ear_morphology3.46067111
6MP0010094_abnormal_chromosome_stability3.41716472
7MP0003077_abnormal_cell_cycle3.38884852
8MP0003111_abnormal_nucleus_morphology3.38661792
9MP0003646_muscle_fatigue2.94238784
10MP0003123_paternal_imprinting2.82428218
11MP0006292_abnormal_olfactory_placode2.66204122
12MP0003937_abnormal_limbs/digits/tail_de2.39562177
13MP0008877_abnormal_DNA_methylation2.37251734
14MP0008932_abnormal_embryonic_tissue2.36527436
15MP0000566_synostosis2.12944468
16MP0001119_abnormal_female_reproductive2.10992100
17MP0008007_abnormal_cellular_replicative2.07082900
18MP0002249_abnormal_larynx_morphology2.06005629
19MP0002085_abnormal_embryonic_tissue1.90189163
20MP0005408_hypopigmentation1.90167531
21MP0001929_abnormal_gametogenesis1.86019074
22MP0002210_abnormal_sex_determination1.84880684
23MP0001730_embryonic_growth_arrest1.84121513
24MP0003699_abnormal_female_reproductive1.84112415
25MP0000350_abnormal_cell_proliferation1.83333969
26MP0008057_abnormal_DNA_replication1.82433681
27MP0010030_abnormal_orbit_morphology1.79987344
28MP0000653_abnormal_sex_gland1.77941674
29MP0003121_genomic_imprinting1.72796637
30MP0005395_other_phenotype1.71697532
31MP0002084_abnormal_developmental_patter1.70627033
32MP0001697_abnormal_embryo_size1.69687921
33MP0004133_heterotaxia1.68695303
34MP0003315_abnormal_perineum_morphology1.65368426
35MP0003567_abnormal_fetal_cardiomyocyte1.63960193
36MP0000778_abnormal_nervous_system1.61579345
37MP0000569_abnormal_digit_pigmentation1.57720797
38MP0008058_abnormal_DNA_repair1.53948673
39MP0002697_abnormal_eye_size1.53662476
40MP0005380_embryogenesis_phenotype1.50751719
41MP0001672_abnormal_embryogenesis/_devel1.50751719
42MP0004264_abnormal_extraembryonic_tissu1.49196361
43MP0002751_abnormal_autonomic_nervous1.45364376
44MP0001145_abnormal_male_reproductive1.42292807
45MP0005499_abnormal_olfactory_system1.36772418
46MP0005394_taste/olfaction_phenotype1.36772418
47MP0006072_abnormal_retinal_apoptosis1.35338764
48MP0003890_abnormal_embryonic-extraembry1.34254197
49MP0000579_abnormal_nail_morphology1.34137867
50MP0000462_abnormal_digestive_system1.32472504
51MP0003136_yellow_coat_color1.28303035
52MP0002736_abnormal_nociception_after1.27433885
53MP0000490_abnormal_crypts_of1.26232002
54MP0001849_ear_inflammation1.25843314
55MP0003122_maternal_imprinting1.25817931
56MP0002638_abnormal_pupillary_reflex1.25726895
57MP0003755_abnormal_palate_morphology1.23472245
58MP0003938_abnormal_ear_development1.22423222
59MP0001346_abnormal_lacrimal_gland1.20264278
60MP0009250_abnormal_appendicular_skeleto1.19810272
61MP0005551_abnormal_eye_electrophysiolog1.19626598
62MP0002254_reproductive_system_inflammat1.19087831
63MP0000537_abnormal_urethra_morphology1.19036652
64MP0003984_embryonic_growth_retardation1.17936512
65MP0000428_abnormal_craniofacial_morphol1.13570131
66MP0002088_abnormal_embryonic_growth/wei1.13456751
67MP0009697_abnormal_copulation1.12589462
68MP0003878_abnormal_ear_physiology1.12537246
69MP0005377_hearing/vestibular/ear_phenot1.12537246
70MP0005253_abnormal_eye_physiology1.12508638
71MP0006054_spinal_hemorrhage1.12163096
72MP0002234_abnormal_pharynx_morphology1.11814368
73MP0002086_abnormal_extraembryonic_tissu1.11317072
74MP0004185_abnormal_adipocyte_glucose1.10375419
75MP0002161_abnormal_fertility/fecundity1.08463901
76MP0003119_abnormal_digestive_system1.08039366
77MP0001968_abnormal_touch/_nociception1.07414993
78MP0002080_prenatal_lethality1.07036298
79MP0001188_hyperpigmentation1.06723286
80MP0004197_abnormal_fetal_growth/weight/1.06404780
81MP0002837_dystrophic_cardiac_calcinosis1.05934282
82MP0003787_abnormal_imprinting1.05754108
83MP0004885_abnormal_endolymph1.05661342
84MP0002160_abnormal_reproductive_system1.03990475
85MP0002019_abnormal_tumor_incidence1.03740315
86MP0003283_abnormal_digestive_organ1.03371068
87MP0002932_abnormal_joint_morphology1.01592256
88MP0001529_abnormal_vocalization1.01329422
89MP0005391_vision/eye_phenotype1.00633722
90MP0000432_abnormal_head_morphology1.00011625
91MP0010234_abnormal_vibrissa_follicle0.99315844
92MP0003195_calcinosis0.97521872
93MP0003935_abnormal_craniofacial_develop0.97412527
94MP0001293_anophthalmia0.96641254
95MP0002233_abnormal_nose_morphology0.95062864
96MP0010678_abnormal_skin_adnexa0.94549261
97MP0002928_abnormal_bile_duct0.94305613
98MP0009703_decreased_birth_body0.94279105
99MP0010368_abnormal_lymphatic_system0.93862933
100* MP0001915_intracranial_hemorrhage0.93839060
101MP0009672_abnormal_birth_weight0.93419576
102MP0003943_abnormal_hepatobiliary_system0.89700868
103MP0009053_abnormal_anal_canal0.89465052
104MP0005389_reproductive_system_phenotype0.89454452
105MP0001286_abnormal_eye_development0.89283955
106MP0010307_abnormal_tumor_latency0.88967619
107MP0002184_abnormal_innervation0.88587155
108MP0002177_abnormal_outer_ear0.88048684
109MP0002752_abnormal_somatic_nervous0.87373387
110* MP0003861_abnormal_nervous_system0.87075859
111MP0001851_eye_inflammation0.86911986
112MP0005367_renal/urinary_system_phenotyp0.86774425
113MP0000516_abnormal_urinary_system0.86774425
114MP0005195_abnormal_posterior_eye0.85715249
115MP0001486_abnormal_startle_reflex0.83690564
116MP0005645_abnormal_hypothalamus_physiol0.83085863
117MP0008789_abnormal_olfactory_epithelium0.82589272
118MP0003880_abnormal_central_pattern0.82541952
119* MP0002116_abnormal_craniofacial_bone0.81819394
120MP0000313_abnormal_cell_death0.81816913
121MP0000026_abnormal_inner_ear0.81294336
122MP0000613_abnormal_salivary_gland0.80948462
123MP0003941_abnormal_skin_development0.80560318
124MP0002938_white_spotting0.80431864
125MP0001919_abnormal_reproductive_system0.80198588
126MP0001485_abnormal_pinna_reflex0.78597412
127MP0000631_abnormal_neuroendocrine_gland0.77767833
128MP0003698_abnormal_male_reproductive0.77570144
129MP0002282_abnormal_trachea_morphology0.76221231
130MP0000383_abnormal_hair_follicle0.75083658
131MP0000049_abnormal_middle_ear0.74855601
132MP0002111_abnormal_tail_morphology0.74705529
133MP0002109_abnormal_limb_morphology0.74427599
134MP0003453_abnormal_keratinocyte_physiol0.74392416
135MP0003786_premature_aging0.74004330
136MP0003942_abnormal_urinary_system0.73698587
137MP0000427_abnormal_hair_cycle0.73649146
138MP0005621_abnormal_cell_physiology0.73070892
139MP0005197_abnormal_uvea_morphology0.72931215
140MP0000639_abnormal_adrenal_gland0.71863269
141MP0002092_abnormal_eye_morphology0.71348870
142MP0000678_abnormal_parathyroid_gland0.70409912
143MP0005076_abnormal_cell_differentiation0.70221376
144MP0005248_abnormal_Harderian_gland0.69298139
145MP0000733_abnormal_muscle_development0.68652703
146MP0002163_abnormal_gland_morphology0.68264625
147MP0005310_abnormal_salivary_gland0.67118252

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)5.64683539
2Birth length less than 3rd percentile (HP:0003561)5.04607710
3Breast hypoplasia (HP:0003187)4.66255855
4Chromsome breakage (HP:0040012)4.15659433
5Patellar aplasia (HP:0006443)4.05131224
6Aplasia/Hypoplasia of the patella (HP:0006498)3.95729696
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90087798
8Papillary thyroid carcinoma (HP:0002895)3.88443036
9Facial hemangioma (HP:0000329)3.88005767
10Adrenal hypoplasia (HP:0000835)3.66392935
11Shawl scrotum (HP:0000049)3.61231903
12Capillary hemangiomas (HP:0005306)3.58702356
13Rib fusion (HP:0000902)3.54080542
14True hermaphroditism (HP:0010459)3.51332686
15Abnormality of the labia minora (HP:0012880)3.29021616
16Oligodactyly (HP:0012165)3.20776040
17Chronic hepatic failure (HP:0100626)3.07042493
18Supernumerary spleens (HP:0009799)2.99440975
19Ectopic kidney (HP:0000086)2.95448111
20Colon cancer (HP:0003003)2.93574858
21Molar tooth sign on MRI (HP:0002419)2.93287278
22Abnormality of midbrain morphology (HP:0002418)2.93287278
23Aplasia/Hypoplasia of the sternum (HP:0006714)2.90679992
24Breast aplasia (HP:0100783)2.89909845
25Abnormality of chromosome stability (HP:0003220)2.87659913
26Aplasia/Hypoplasia of the breasts (HP:0010311)2.87236434
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85414538
28Abnormality of the fingertips (HP:0001211)2.83802952
29Oligodactyly (hands) (HP:0001180)2.75865416
30Abnormality of the phalanges of the hallux (HP:0010057)2.74886679
31Septo-optic dysplasia (HP:0100842)2.71276654
32Aplasia involving forearm bones (HP:0009822)2.69361276
33Absent forearm bone (HP:0003953)2.69361276
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.68648724
35Absent radius (HP:0003974)2.68442537
36Meckel diverticulum (HP:0002245)2.66117501
37Cortical dysplasia (HP:0002539)2.63803927
38Carpal bone hypoplasia (HP:0001498)2.59861688
39Intestinal atresia (HP:0011100)2.56172546
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53935578
41Flat capital femoral epiphysis (HP:0003370)2.48834130
42Secondary amenorrhea (HP:0000869)2.48064045
43Anophthalmia (HP:0000528)2.48029874
44Abnormality of the preputium (HP:0100587)2.47932502
45Abnormality of the ileum (HP:0001549)2.47776987
46Abnormal lung lobation (HP:0002101)2.45688585
47Small intestinal stenosis (HP:0012848)2.41802918
48Duodenal stenosis (HP:0100867)2.41802918
49Nephronophthisis (HP:0000090)2.41257913
50Microglossia (HP:0000171)2.39978101
51Premature ovarian failure (HP:0008209)2.39012455
52Acute myeloid leukemia (HP:0004808)2.36762602
53Anencephaly (HP:0002323)2.29394296
54Rhabdomyosarcoma (HP:0002859)2.25561309
55Overlapping toe (HP:0001845)2.24476015
56Medulloblastoma (HP:0002885)2.23125100
57Nephroblastoma (Wilms tumor) (HP:0002667)2.22826002
58Chronic bronchitis (HP:0004469)2.21120012
59Hypoplasia of the pons (HP:0012110)2.19012290
60Short thumb (HP:0009778)2.16632835
61Cystic liver disease (HP:0006706)2.16531745
62Volvulus (HP:0002580)2.15372199
63Anterior segment dysgenesis (HP:0007700)2.14019059
64Aplastic anemia (HP:0001915)2.13976446
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.12797906
66Hypoplasia of the fovea (HP:0007750)2.12797906
67Abnormality of the pons (HP:0007361)2.12348760
68Sclerocornea (HP:0000647)2.11552274
69Lip pit (HP:0100267)2.11136115
70Esophageal atresia (HP:0002032)2.10807702
71Abnormality of the fovea (HP:0000493)2.10655091
72Cerebellar dysplasia (HP:0007033)2.09090041
73Sloping forehead (HP:0000340)2.07673881
74Abnormality of cochlea (HP:0000375)2.07640465
75Abnormality of chromosome segregation (HP:0002916)2.07343383
76Thyroid carcinoma (HP:0002890)2.07240207
77Abnormality of the duodenum (HP:0002246)2.07196926
78Myelodysplasia (HP:0002863)2.06311010
79Anomalous pulmonary venous return (HP:0010772)2.05955167
80Sandal gap (HP:0001852)2.05729967
81Abnormality of the renal medulla (HP:0100957)2.04197565
82Embryonal renal neoplasm (HP:0011794)2.04097904
83Dandy-Walker malformation (HP:0001305)2.03021003
84Type II lissencephaly (HP:0007260)2.02662769
85Gastrointestinal atresia (HP:0002589)2.02661878
86Pancreatic fibrosis (HP:0100732)2.02212002
87Optic nerve hypoplasia (HP:0000609)2.01890533
88Preaxial hand polydactyly (HP:0001177)2.01657561
89Bilateral microphthalmos (HP:0007633)2.01294551
90Oral leukoplakia (HP:0002745)2.00333670
91Stenosis of the external auditory canal (HP:0000402)1.99305384
92Impulsivity (HP:0100710)1.98218949
93Pendular nystagmus (HP:0012043)1.97885372
94Postaxial foot polydactyly (HP:0001830)1.97443051
95Neoplasm of the oral cavity (HP:0100649)1.94891409
96Hemivertebrae (HP:0002937)1.94435975
97Abnormality of the intervertebral disk (HP:0005108)1.94228397
98Hypoplastic iliac wings (HP:0002866)1.94104496
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.93550807
100Scrotal hypoplasia (HP:0000046)1.93436748
101Progressive inability to walk (HP:0002505)1.92470249
102Synostosis of carpal bones (HP:0005048)1.92372192
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91475997
104Abnormality of lateral ventricle (HP:0030047)1.91455067
105Triphalangeal thumb (HP:0001199)1.91306216
106Atresia of the external auditory canal (HP:0000413)1.90743464
107Diastasis recti (HP:0001540)1.88845141
108Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87401512
109Absent septum pellucidum (HP:0001331)1.86440161
110Hypoplastic pelvis (HP:0008839)1.86422408
111Medial flaring of the eyebrow (HP:0010747)1.86083547
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.85973987
113Bifid tongue (HP:0010297)1.85399423
114Protruding tongue (HP:0010808)1.83912793
115Absent/shortened dynein arms (HP:0200106)1.83776764
116Dynein arm defect of respiratory motile cilia (HP:0012255)1.83776764
117Pancreatic cysts (HP:0001737)1.82505811
118Cerebral hypomyelination (HP:0006808)1.82266164
119Abnormality of the pulmonary veins (HP:0011718)1.81372208
120Glioma (HP:0009733)1.80451882
121Congenital stationary night blindness (HP:0007642)1.79531494
122Genital tract atresia (HP:0001827)1.78645567
123Hypergonadotropic hypogonadism (HP:0000815)1.78089758
124Vaginal atresia (HP:0000148)1.78051194
125Horseshoe kidney (HP:0000085)1.76843022
126Midline defect of the nose (HP:0004122)1.76757031
127Lissencephaly (HP:0001339)1.76089425
128Holoprosencephaly (HP:0001360)1.75258216
129Renal hypoplasia (HP:0000089)1.74014383
130Abnormality of the carotid arteries (HP:0005344)1.73958643
131Male pseudohermaphroditism (HP:0000037)1.73704783
132Arterial tortuosity (HP:0005116)1.73189545
133Hyperglycinuria (HP:0003108)1.73166749
134Small hand (HP:0200055)1.72643607
135Abnormality of the renal cortex (HP:0011035)1.72381083
136Pulmonary fibrosis (HP:0002206)1.71682365
137Microretrognathia (HP:0000308)1.71645601
138Cafe-au-lait spot (HP:0000957)1.70707947
139Muscle fiber atrophy (HP:0100295)1.70539731
140Ependymoma (HP:0002888)1.69978926
141Clubbing of toes (HP:0100760)1.69191676
142Abnormal spermatogenesis (HP:0008669)1.69063515
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.68697934
144Primary amenorrhea (HP:0000786)1.68431723
145Abnormality of the septum pellucidum (HP:0007375)1.68206772
146Postaxial hand polydactyly (HP:0001162)1.68108540
147Sparse lateral eyebrow (HP:0005338)1.68035408
148Short 4th metacarpal (HP:0010044)1.67458494
149Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67458494
150Cupped ear (HP:0000378)1.67153621
151Aqueductal stenosis (HP:0002410)1.66809318
152Cutaneous finger syndactyly (HP:0010554)1.66582863
153Hyperventilation (HP:0002883)1.65963635
154Abnormal number of erythroid precursors (HP:0012131)1.63426955
155Inability to walk (HP:0002540)1.62329356
156Abnormal biliary tract physiology (HP:0012439)1.61343619
157Bile duct proliferation (HP:0001408)1.61343619
158Hepatoblastoma (HP:0002884)1.60255833
159Partial agenesis of the corpus callosum (HP:0001338)1.59979990
160Neoplasm of the adrenal cortex (HP:0100641)1.59177202
161Narrow forehead (HP:0000341)1.58587506
162Drooling (HP:0002307)1.58232179
163Abnormality of the pubic bones (HP:0003172)1.57970977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.68309066
2LATS23.73822506
3PLK43.46334015
4CDC73.42292181
5STK38L3.31813883
6MAP3K63.30643726
7MOS3.08991788
8TNIK3.00030192
9ERBB42.73822105
10KSR22.73164600
11FRK2.72339880
12TAOK32.63170682
13TTK2.60454449
14BMPR1B2.54287189
15WNK32.53284989
16PNCK2.48063564
17MAP3K132.28481178
18ZAK2.25455206
19NEK22.18880558
20CDK82.11556037
21BMPR21.99822713
22BRAF1.96191405
23ARAF1.93758716
24BUB11.93549321
25MAP3K91.89464228
26MELK1.86425332
27DYRK21.85380002
28CASK1.83384145
29TAOK11.78399701
30CHEK21.78394541
31TRIM281.77506732
32STK31.76413492
33RAF11.75447523
34MUSK1.71398294
35EEF2K1.61356304
36MAP3K101.60913687
37TSSK61.59960614
38TAF11.53247539
39PLK11.52276667
40ACVR1B1.51604093
41PRKD31.49285934
42WEE11.47170434
43MAPK151.46848876
44CDK91.46787395
45MST41.42468073
46BRSK21.41287551
47SRPK11.34719218
48TYRO31.30103370
49EIF2AK31.28225941
50BRD41.25608373
51KSR11.24503738
52ADRBK21.24190218
53STK101.22750054
54MAP3K81.19477855
55NLK1.09462193
56WNK41.08411961
57AURKB1.08103638
58ABL21.06399791
59CSNK1G11.04712745
60GRK11.04238129
61VRK20.97208475
62CAMK1G0.96995535
63STK160.93624169
64TLK10.93552519
65RPS6KA40.93160109
66MAPKAPK30.92153381
67CDK70.92075377
68AURKA0.91141473
69FGFR20.90839998
70CDK120.89486148
71PLK30.88618718
72CAMK1D0.87506661
73CDK40.82162467
74VRK10.80669135
75CAMKK20.78584074
76CHEK10.78566830
77CDK30.78356652
78CSNK1G30.76768572
79OXSR10.74598000
80BRSK10.74156149
81DYRK30.69668293
82FLT30.68766683
83MKNK10.67477469
84DMPK0.66021940
85MAP3K50.66013468
86ATM0.65611153
87PRKD20.63308989
88MAP4K20.63293420
89MAP2K70.62806153
90MAPK130.62699102
91FGFR10.62284270
92NUAK10.62187335
93INSRR0.61981483
94PAK60.61518261
95CCNB10.61436530
96CSNK1A1L0.60709250
97ERBB30.59392296
98CSNK1G20.59260162
99DYRK1A0.56422645
100RPS6KB20.55680079
101EIF2AK20.55027881
102PLK20.54846906
103PRKCG0.54668445
104ATR0.53374847
105JAK30.51711036
106PBK0.50443990
107MKNK20.48978760
108YES10.48658253
109PKN10.48556825
110MAPKAPK50.48252871
111SGK20.47071454
112HIPK20.45838256
113* CDK20.44497447
114PRKCE0.44188258
115CDK10.41608093
116PASK0.40436402
117CSNK1E0.39837871
118AKT30.38936702
119MARK10.38400300
120PRKAA20.36302144
121PRKCQ0.35420007
122STK240.34741642
123CDK190.34616472
124PRKDC0.34530614
125STK110.33708772
126PAK10.32465631
127PIM10.31922061
128CSNK1A10.31780814
129CAMKK10.30866585
130TESK20.30842853
131PRKAA10.30505944
132NTRK20.30433859
133TGFBR10.30161450
134STK40.29049471
135SGK4940.28448642
136SGK2230.28448642
137STK380.28071535
138NEK10.27327866
139NEK90.27261876
140ABL10.27159645
141CHUK0.25244500
142MARK20.25206257
143CDK60.23388407
144MAP3K40.23221938
145RET0.21661048
146MET0.20222118
147BCR0.19353480
148PRKCI0.18896259
149CSNK1D0.18638176
150MAPK110.18507223
151EIF2AK10.17248189
152CDK150.14940286
153STK390.14444343

Predicted pathways (KEGG)

RankGene SetZ-score
1* Cell cycle_Homo sapiens_hsa041104.08398506
2Basal transcription factors_Homo sapiens_hsa030223.81759462
3RNA degradation_Homo sapiens_hsa030183.38987544
4RNA polymerase_Homo sapiens_hsa030203.11558636
5DNA replication_Homo sapiens_hsa030302.94855316
6Homologous recombination_Homo sapiens_hsa034402.87029373
7Mismatch repair_Homo sapiens_hsa034302.67205089
8RNA transport_Homo sapiens_hsa030132.58663566
9Base excision repair_Homo sapiens_hsa034102.44346319
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42205835
11Fanconi anemia pathway_Homo sapiens_hsa034602.41122616
12Nucleotide excision repair_Homo sapiens_hsa034202.32775593
13Vitamin B6 metabolism_Homo sapiens_hsa007502.08295781
14Circadian rhythm_Homo sapiens_hsa047102.06714059
15Ovarian steroidogenesis_Homo sapiens_hsa049132.01973788
16Oocyte meiosis_Homo sapiens_hsa041142.01931614
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.00220972
18p53 signaling pathway_Homo sapiens_hsa041151.96509338
19Phototransduction_Homo sapiens_hsa047441.86434397
20mRNA surveillance pathway_Homo sapiens_hsa030151.85654619
21Spliceosome_Homo sapiens_hsa030401.79319367
22Propanoate metabolism_Homo sapiens_hsa006401.75322400
23Ribosome_Homo sapiens_hsa030101.71438504
24Pancreatic cancer_Homo sapiens_hsa052121.68219345
25* TGF-beta signaling pathway_Homo sapiens_hsa043501.67398821
26Pyrimidine metabolism_Homo sapiens_hsa002401.64915795
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61576896
28Selenocompound metabolism_Homo sapiens_hsa004501.59979673
29Ether lipid metabolism_Homo sapiens_hsa005651.57442768
30Non-homologous end-joining_Homo sapiens_hsa034501.57164751
31Linoleic acid metabolism_Homo sapiens_hsa005911.54752702
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54491872
33MicroRNAs in cancer_Homo sapiens_hsa052061.50330924
34Butanoate metabolism_Homo sapiens_hsa006501.49519015
35Hippo signaling pathway_Homo sapiens_hsa043901.49219968
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48917351
37Nitrogen metabolism_Homo sapiens_hsa009101.36955618
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35714370
39One carbon pool by folate_Homo sapiens_hsa006701.32234015
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30839292
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29305862
42Colorectal cancer_Homo sapiens_hsa052101.25092143
43Nicotine addiction_Homo sapiens_hsa050331.18692860
44Notch signaling pathway_Homo sapiens_hsa043301.18339955
45Basal cell carcinoma_Homo sapiens_hsa052171.16628917
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15699297
47Folate biosynthesis_Homo sapiens_hsa007901.09051236
48Herpes simplex infection_Homo sapiens_hsa051681.08781749
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08772148
50Adherens junction_Homo sapiens_hsa045201.08618172
51Thyroid cancer_Homo sapiens_hsa052161.07228439
52Hedgehog signaling pathway_Homo sapiens_hsa043401.03153820
53Dorso-ventral axis formation_Homo sapiens_hsa043200.98401848
54Taste transduction_Homo sapiens_hsa047420.95938974
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90493322
56Purine metabolism_Homo sapiens_hsa002300.90059790
57Renal cell carcinoma_Homo sapiens_hsa052110.89629888
58Huntingtons disease_Homo sapiens_hsa050160.87882975
59Alcoholism_Homo sapiens_hsa050340.86688750
60HTLV-I infection_Homo sapiens_hsa051660.85765422
61Small cell lung cancer_Homo sapiens_hsa052220.84641396
62Prolactin signaling pathway_Homo sapiens_hsa049170.83586678
63Parkinsons disease_Homo sapiens_hsa050120.79254056
64Prostate cancer_Homo sapiens_hsa052150.78723757
65Bladder cancer_Homo sapiens_hsa052190.78451465
66Epstein-Barr virus infection_Homo sapiens_hsa051690.77139184
67Choline metabolism in cancer_Homo sapiens_hsa052310.76530355
68Shigellosis_Homo sapiens_hsa051310.74169577
69Wnt signaling pathway_Homo sapiens_hsa043100.74031229
70Steroid biosynthesis_Homo sapiens_hsa001000.73397697
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.73357470
72Primary immunodeficiency_Homo sapiens_hsa053400.71934548
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70147974
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66992697
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66340827
76Olfactory transduction_Homo sapiens_hsa047400.64667575
77Viral carcinogenesis_Homo sapiens_hsa052030.64470150
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62688535
79Oxidative phosphorylation_Homo sapiens_hsa001900.61380123
80FoxO signaling pathway_Homo sapiens_hsa040680.60374823
81Axon guidance_Homo sapiens_hsa043600.60203661
82Hepatitis B_Homo sapiens_hsa051610.58724449
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57589152
84Chronic myeloid leukemia_Homo sapiens_hsa052200.57503598
85Endometrial cancer_Homo sapiens_hsa052130.57242000
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56216208
87GnRH signaling pathway_Homo sapiens_hsa049120.53532177
88Caffeine metabolism_Homo sapiens_hsa002320.52878577
89mTOR signaling pathway_Homo sapiens_hsa041500.52710134
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52629689
91Serotonergic synapse_Homo sapiens_hsa047260.52505444
92Tight junction_Homo sapiens_hsa045300.51922699
93Pathways in cancer_Homo sapiens_hsa052000.51462646
94Tryptophan metabolism_Homo sapiens_hsa003800.51449452
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50942428
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50780921
97Arachidonic acid metabolism_Homo sapiens_hsa005900.49605184
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46216089
99Glutamatergic synapse_Homo sapiens_hsa047240.43822297
100Protein export_Homo sapiens_hsa030600.43165736
101Arginine and proline metabolism_Homo sapiens_hsa003300.43106113
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42536981
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42331651
104Regulation of autophagy_Homo sapiens_hsa041400.41216335
105VEGF signaling pathway_Homo sapiens_hsa043700.41025847
106Pyruvate metabolism_Homo sapiens_hsa006200.39576112
107Ras signaling pathway_Homo sapiens_hsa040140.38976919
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38534133
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38391394
110Metabolic pathways_Homo sapiens_hsa011000.36540415
111Non-small cell lung cancer_Homo sapiens_hsa052230.36259101
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35817866
113TNF signaling pathway_Homo sapiens_hsa046680.35777138
114Melanoma_Homo sapiens_hsa052180.34847830
115Long-term depression_Homo sapiens_hsa047300.34814499
116Peroxisome_Homo sapiens_hsa041460.34469102
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33023989
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32726068
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32713629
120Influenza A_Homo sapiens_hsa051640.31866629
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.30695777
122Morphine addiction_Homo sapiens_hsa050320.29534989
123Retinol metabolism_Homo sapiens_hsa008300.28791375
124Sphingolipid metabolism_Homo sapiens_hsa006000.28465847
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27355461
126Dopaminergic synapse_Homo sapiens_hsa047280.26506202
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25086922
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.24730725
129Glutathione metabolism_Homo sapiens_hsa004800.24443902
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24310869
131Cocaine addiction_Homo sapiens_hsa050300.23961587
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.23717228
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.23669203
134Fatty acid metabolism_Homo sapiens_hsa012120.23314959
135Pentose phosphate pathway_Homo sapiens_hsa000300.22271519
136Systemic lupus erythematosus_Homo sapiens_hsa053220.21927403
137MAPK signaling pathway_Homo sapiens_hsa040100.21847368
138Vitamin digestion and absorption_Homo sapiens_hsa049770.21633313
139Alzheimers disease_Homo sapiens_hsa050100.21631704
140Lysine degradation_Homo sapiens_hsa003100.20672068
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20139222
142Biosynthesis of amino acids_Homo sapiens_hsa012300.18244136
143Other glycan degradation_Homo sapiens_hsa005110.18139040
144Apoptosis_Homo sapiens_hsa042100.17819350
145Proteasome_Homo sapiens_hsa030500.17445502
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16895641

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