E2F6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.40763938
2muscle filament sliding (GO:0030049)6.40763938
3sarcomere organization (GO:0045214)5.93970735
4regulation of skeletal muscle contraction (GO:0014819)5.93397781
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.45201421
6regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.35720894
7plasma membrane repair (GO:0001778)5.31872063
8tricarboxylic acid cycle (GO:0006099)5.29804864
9cardiac myofibril assembly (GO:0055003)5.13694387
10actin-mediated cell contraction (GO:0070252)5.04633676
11myofibril assembly (GO:0030239)4.94594810
12regulation of acyl-CoA biosynthetic process (GO:0050812)4.66776151
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.61177504
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.55441967
15regulation of cofactor metabolic process (GO:0051193)4.52145994
16regulation of coenzyme metabolic process (GO:0051196)4.52145994
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.51685598
18cardiac muscle contraction (GO:0060048)4.47397312
19mitotic chromosome condensation (GO:0007076)4.40700691
20carnitine shuttle (GO:0006853)4.34219438
21IMP metabolic process (GO:0046040)4.18751025
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.17778187
23striated muscle contraction (GO:0006941)4.12031846
24skeletal muscle contraction (GO:0003009)4.05206719
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.02398601
26cardiac muscle cell development (GO:0055013)4.00973752
27IMP biosynthetic process (GO:0006188)3.94082099
28DNA unwinding involved in DNA replication (GO:0006268)3.93959712
29regulation of sulfur metabolic process (GO:0042762)3.92503876
30regulation of relaxation of muscle (GO:1901077)3.90112032
31DNA strand elongation involved in DNA replication (GO:0006271)3.85800695
32actomyosin structure organization (GO:0031032)3.84948411
33DNA strand elongation (GO:0022616)3.80441243
34actin filament-based movement (GO:0030048)3.79653018
35cardiac cell development (GO:0055006)3.74715113
36telomere maintenance via semi-conservative replication (GO:0032201)3.74232672
37fatty acid transmembrane transport (GO:1902001)3.71389890
382-oxoglutarate metabolic process (GO:0006103)3.67637633
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.63167484
40chromatin remodeling at centromere (GO:0031055)3.62707630
41mitotic sister chromatid cohesion (GO:0007064)3.61894521
42nuclear pore complex assembly (GO:0051292)3.61288727
43nuclear pore organization (GO:0006999)3.53860693
44NADH metabolic process (GO:0006734)3.50834867
45maturation of SSU-rRNA (GO:0030490)3.50482078
46oxaloacetate metabolic process (GO:0006107)3.48395214
47mitotic metaphase plate congression (GO:0007080)3.48178683
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47436459
49oxidative phosphorylation (GO:0006119)3.45404689
50CENP-A containing nucleosome assembly (GO:0034080)3.44490810
51glycogen catabolic process (GO:0005980)3.44360561
52regulation of cell communication by electrical coupling (GO:0010649)3.43059791
53succinate metabolic process (GO:0006105)3.40065735
54DNA replication checkpoint (GO:0000076)3.38943267
55skeletal muscle adaptation (GO:0043501)3.30641106
56regulation of actin filament-based movement (GO:1903115)3.30336367
57negative regulation of cell size (GO:0045792)3.30105854
58ribosomal small subunit biogenesis (GO:0042274)3.26821285
59telomere maintenance via recombination (GO:0000722)3.23379991
60gonadal mesoderm development (GO:0007506)3.22622388
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.20831339
62heart trabecula formation (GO:0060347)3.20121171
63lysine catabolic process (GO:0006554)3.17506671
64lysine metabolic process (GO:0006553)3.17506671
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.15755086
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.15536175
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15536175
68glucan catabolic process (GO:0009251)3.14831220
69mitotic recombination (GO:0006312)3.14668023
70tricarboxylic acid metabolic process (GO:0072350)3.09273409
71regulation of fatty acid oxidation (GO:0046320)3.08365796
72regulation of sarcomere organization (GO:0060297)3.07959557
73* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07797986
74establishment of integrated proviral latency (GO:0075713)3.07764547
75purine nucleotide salvage (GO:0032261)3.07692854
76skeletal muscle tissue regeneration (GO:0043403)3.06730738
77ribosomal small subunit assembly (GO:0000028)3.06092366
78creatine metabolic process (GO:0006600)3.04958828
79regulation of sister chromatid cohesion (GO:0007063)3.00721143
80cardiac muscle hypertrophy (GO:0003300)3.00390615
81DNA replication-independent nucleosome assembly (GO:0006336)3.00175669
82DNA replication-independent nucleosome organization (GO:0034724)3.00175669
83glucan biosynthetic process (GO:0009250)2.98150427
84glycogen biosynthetic process (GO:0005978)2.98150427
85muscle contraction (GO:0006936)2.97054822
86metaphase plate congression (GO:0051310)2.96710542
87carnitine transmembrane transport (GO:1902603)2.96118844
88ribonucleoprotein complex biogenesis (GO:0022613)2.94863641
89ribosome biogenesis (GO:0042254)2.94425464
90DNA replication initiation (GO:0006270)2.94336659
91striated muscle cell development (GO:0055002)2.93200620
92protein localization to chromosome, centromeric region (GO:0071459)2.92908390
93ribosomal large subunit biogenesis (GO:0042273)2.92630223
94striated muscle hypertrophy (GO:0014897)2.92608465
95mitotic sister chromatid segregation (GO:0000070)2.92476723
96glycogen metabolic process (GO:0005977)2.92434198
97peptidyl-lysine dimethylation (GO:0018027)2.89169377
98pre-miRNA processing (GO:0031054)2.88543671
99cellular polysaccharide catabolic process (GO:0044247)2.88280570
100cellular protein complex localization (GO:0034629)2.87038495
101protein localization to kinetochore (GO:0034501)2.85733377
102paraxial mesoderm development (GO:0048339)2.85527545
103heart contraction (GO:0060047)2.85179779
104heart process (GO:0003015)2.85179779
105cellular glucan metabolic process (GO:0006073)2.84397191
106glucan metabolic process (GO:0044042)2.84397191
107chaperone-mediated protein complex assembly (GO:0051131)2.84270388
108glucocorticoid receptor signaling pathway (GO:0042921)2.83163499
109cardiac muscle tissue morphogenesis (GO:0055008)2.83028868
110ribosome assembly (GO:0042255)2.81284645
111muscle hypertrophy (GO:0014896)2.80507352
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.78857401
113kinetochore organization (GO:0051383)2.78637474
114pore complex assembly (GO:0046931)2.78077185
115pattern specification involved in kidney development (GO:0061004)2.77903986
116response to muscle activity (GO:0014850)2.77830723
117regulation of translational termination (GO:0006449)2.77628165
118protein hydroxylation (GO:0018126)2.77411340
119hippo signaling (GO:0035329)2.77379691
120translational termination (GO:0006415)2.75229520
121sister chromatid segregation (GO:0000819)2.74178216
122regulation of striated muscle contraction (GO:0006942)2.72324112
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71687444
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.70950871
125regulation of mitochondrial translation (GO:0070129)2.70852636
126L-serine metabolic process (GO:0006563)2.70805259
127protein complex localization (GO:0031503)2.70700722
128regulation of centriole replication (GO:0046599)2.70240486
129muscle system process (GO:0003012)2.70154735
130muscle cell development (GO:0055001)2.69264406
131viral transcription (GO:0019083)2.68789384
132muscle tissue morphogenesis (GO:0060415)2.67540503
133regulation of ATP catabolic process (GO:1903289)2.66918341
134regulation of ATPase activity (GO:0043462)2.66918341
135striated muscle adaptation (GO:0014888)2.65678362
136proteasome assembly (GO:0043248)2.65575134
137valine metabolic process (GO:0006573)2.65426770
138folic acid-containing compound biosynthetic process (GO:0009396)2.65001057
139polysaccharide catabolic process (GO:0000272)2.64662132
140translational initiation (GO:0006413)2.63623904
141mitochondrial RNA metabolic process (GO:0000959)2.63167621
142histone exchange (GO:0043486)2.62887108
143nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.62578175
144nucleobase-containing small molecule interconversion (GO:0015949)2.61938715
145carnitine transport (GO:0015879)2.61661573
146amino-acid betaine transport (GO:0015838)2.61661573
147regulation of membrane repolarization (GO:0060306)2.60335163
148negative regulation of cardiac muscle tissue growth (GO:0055022)2.60011135
149negative regulation of heart growth (GO:0061117)2.60011135
150tRNA aminoacylation for protein translation (GO:0006418)2.58083382
151SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57702786
152tRNA aminoacylation (GO:0043039)2.56635696
153amino acid activation (GO:0043038)2.56635696
154DNA replication-dependent nucleosome organization (GO:0034723)2.56068961
155DNA replication-dependent nucleosome assembly (GO:0006335)2.56068961
156formation of translation preinitiation complex (GO:0001731)2.55687856
157cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54768226
158mitochondrial fusion (GO:0008053)2.54711204
159heterochromatin organization (GO:0070828)2.53262838
160cotranslational protein targeting to membrane (GO:0006613)2.52913178
161maturation of 5.8S rRNA (GO:0000460)2.52414840
162regulation of translational fidelity (GO:0006450)2.52067079
163transcription from mitochondrial promoter (GO:0006390)2.51998045
164muscle fiber development (GO:0048747)2.51718977
165telomere maintenance via telomere lengthening (GO:0010833)2.51654474
166pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.51106045
167protein targeting to ER (GO:0045047)2.51019202
168DNA double-strand break processing (GO:0000729)2.51011484
169regulation of centrosome cycle (GO:0046605)2.50555787
170negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49361455
171negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.48512075
172pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48161858
173kinetochore assembly (GO:0051382)2.48080669
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45886000
175chromosome condensation (GO:0030261)2.45503987
176mitotic nuclear envelope disassembly (GO:0007077)2.45103232
177positive regulation of chromosome segregation (GO:0051984)2.44405327
178transcription-coupled nucleotide-excision repair (GO:0006283)2.43023133
179regulation of chromosome segregation (GO:0051983)2.42401021
180rRNA processing (GO:0006364)2.41626171
181translational elongation (GO:0006414)2.40760829
182protein localization to endoplasmic reticulum (GO:0070972)2.36727477
183anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.36553037
184cellular component biogenesis (GO:0044085)2.36135383
185DNA topological change (GO:0006265)2.36131754
186negative regulation of meiosis (GO:0045835)2.35287574
187cell cycle G1/S phase transition (GO:0044843)2.34877106
188G1/S transition of mitotic cell cycle (GO:0000082)2.34877106
189chromatin assembly or disassembly (GO:0006333)2.34605971
190chromosome segregation (GO:0007059)2.34205718
1917-methylguanosine mRNA capping (GO:0006370)2.33990099
192establishment of viral latency (GO:0019043)2.33640837
193viral life cycle (GO:0019058)2.33531134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57492078
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.33653900
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.02385875
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75081222
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.49536358
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.07413776
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.04777019
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.91917547
9ZNF263_19887448_ChIP-Seq_K562_Human2.68868732
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61759676
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60605866
12MYC_22102868_ChIP-Seq_BL_Human2.59875455
13AR_21909140_ChIP-Seq_LNCAP_Human2.34398485
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32931675
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32793891
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.32442952
17ELK1_19687146_ChIP-ChIP_HELA_Human2.18949178
18POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16713921
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13413047
20CIITA_25753668_ChIP-Seq_RAJI_Human2.04861528
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04288455
22ZFX_18555785_ChIP-Seq_MESCs_Mouse2.04211452
23* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00474844
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99446049
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91438423
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89128173
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88726974
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.87350096
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87323220
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84741682
31CLOCK_20551151_ChIP-Seq_293T_Human1.84068041
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83451739
33NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.81343436
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78993103
35BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.73880057
36XRN2_22483619_ChIP-Seq_HELA_Human1.73857848
37GATA4_21415370_ChIP-Seq_HL-1_Mouse1.68882874
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68085729
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63722251
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.63404202
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61167757
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.59922920
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59902417
44TCF7_22412390_ChIP-Seq_EML_Mouse1.59728095
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.59369513
46VDR_21846776_ChIP-Seq_THP-1_Human1.57403626
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56744169
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55933382
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54606625
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.54454487
51* TBX20_22328084_ChIP-Seq_HEART_Mouse1.54454487
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.50050607
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49829685
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48096990
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45201408
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44758377
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.44662885
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43235260
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42949931
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42824718
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41936045
62KDM2B_26808549_Chip-Seq_DND41_Human1.41695577
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41565392
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38827497
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35607310
66* NOTCH1_21737748_ChIP-Seq_TLL_Human1.35330604
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.34232006
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33093908
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32325129
70* GABP_19822575_ChIP-Seq_HepG2_Human1.31722343
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31438865
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30935215
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29889928
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29845924
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.29494426
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.28972196
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28961819
78ATF3_27146783_Chip-Seq_COLON_Human1.28527606
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28371842
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25385044
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24702525
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22796842
83GATA1_22025678_ChIP-Seq_K562_Human1.22041120
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19509676
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18501673
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15664191
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14804287
88* SOX17_20123909_ChIP-Seq_XEN_Mouse1.14643142
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14239491
90CHD1_26751641_Chip-Seq_LNCaP_Human1.13338978
91SCL_19346495_ChIP-Seq_HPC-7_Human1.12735474
92FOXP3_21729870_ChIP-Seq_TREG_Human1.11696259
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11205311
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11117279
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11083005
96* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.11072338
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10962347
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10905514
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10035866
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09704085
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09525995
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08296105
103MAF_26560356_Chip-Seq_TH1_Human1.08089312
104MYC_18940864_ChIP-ChIP_HL60_Human1.08046249
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.04228926
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03255357
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02648592
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02639861
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01836080
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.01792904
111DCP1A_22483619_ChIP-Seq_HELA_Human1.01375919
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00897182
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00692907
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00522916
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99618950
116KDM5A_27292631_Chip-Seq_BREAST_Human0.98954399
117* TTF2_22483619_ChIP-Seq_HELA_Human0.98888502
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.98542112
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.97043271
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96993719
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96351751
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95945702
123VDR_23849224_ChIP-Seq_CD4+_Human0.95535045
124CTCF_21964334_Chip-Seq_Bcells_Human0.94873694
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94554103
126* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94223383
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.93899428
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93401649
129* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93356314
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93258732
131NCOR1_26117541_ChIP-Seq_K562_Human0.92749127
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92550840
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.92339273
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92176087
135TFEB_21752829_ChIP-Seq_HELA_Human0.91947201
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91515946
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91059309
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90906222
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90758857
140KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90758857
141KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90758857
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.84840090
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83143601
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82498312
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81168439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.15717441
2MP0000751_myopathy4.55736288
3MP0004145_abnormal_muscle_electrophysio3.77824541
4MP0000749_muscle_degeneration3.75018734
5MP0004084_abnormal_cardiac_muscle3.70961768
6MP0002837_dystrophic_cardiac_calcinosis3.58485900
7MP0004036_abnormal_muscle_relaxation3.22805218
8MP0004215_abnormal_myocardial_fiber2.90447639
9MP0004087_abnormal_muscle_fiber2.90011979
10MP0000747_muscle_weakness2.85595022
11MP0005330_cardiomyopathy2.76365925
12MP0002106_abnormal_muscle_physiology2.71400940
13MP0003123_paternal_imprinting2.63338721
14MP0002269_muscular_atrophy2.58787786
15MP0006292_abnormal_olfactory_placode2.54225835
16MP0000750_abnormal_muscle_regeneration2.50098651
17MP0008932_abnormal_embryonic_tissue2.49584015
18MP0008058_abnormal_DNA_repair2.49181899
19MP0004233_abnormal_muscle_weight2.45213572
20MP0004130_abnormal_muscle_cell2.41183693
21MP0000759_abnormal_skeletal_muscle2.37064827
22MP0005369_muscle_phenotype2.27151805
23MP0005620_abnormal_muscle_contractility2.18015387
24MP0010630_abnormal_cardiac_muscle2.17675240
25MP0003705_abnormal_hypodermis_morpholog2.04748016
26MP0008775_abnormal_heart_ventricle2.02884794
27MP0008007_abnormal_cellular_replicative2.00736269
28MP0003221_abnormal_cardiomyocyte_apopto2.00284569
29MP0001293_anophthalmia1.93984522
30MP0003567_abnormal_fetal_cardiomyocyte1.85201605
31MP0003941_abnormal_skin_development1.84207932
32MP0005385_cardiovascular_system_phenoty1.82611533
33MP0001544_abnormal_cardiovascular_syste1.82611533
34MP0002972_abnormal_cardiac_muscle1.82099358
35MP0001529_abnormal_vocalization1.76837716
36MP0002396_abnormal_hematopoietic_system1.73498432
37MP0006036_abnormal_mitochondrial_physio1.73355399
38MP0000733_abnormal_muscle_development1.69254500
39MP0006138_congestive_heart_failure1.61208266
40MP0003890_abnormal_embryonic-extraembry1.60188962
41MP0003136_yellow_coat_color1.59686710
42MP0002938_white_spotting1.58386058
43MP0002697_abnormal_eye_size1.57836725
44MP0004484_altered_response_of1.57529194
45MP0010352_gastrointestinal_tract_polyps1.52985715
46MP0003937_abnormal_limbs/digits/tail_de1.51248988
47MP0008789_abnormal_olfactory_epithelium1.49169057
48MP0003137_abnormal_impulse_conducting1.48968341
49MP0003122_maternal_imprinting1.45936478
50MP0003942_abnormal_urinary_system1.45464649
51MP0005394_taste/olfaction_phenotype1.42047096
52MP0005499_abnormal_olfactory_system1.42047096
53MP0004147_increased_porphyrin_level1.38595493
54MP0000372_irregular_coat_pigmentation1.34685632
55MP0005666_abnormal_adipose_tissue1.34530970
56MP0006054_spinal_hemorrhage1.34178613
57MP0010368_abnormal_lymphatic_system1.33457592
58MP0002233_abnormal_nose_morphology1.32118126
59MP0002108_abnormal_muscle_morphology1.30158468
60MP0002092_abnormal_eye_morphology1.29434414
61MP0000266_abnormal_heart_morphology1.28921761
62MP0002160_abnormal_reproductive_system1.28735783
63MP0008057_abnormal_DNA_replication1.26867087
64MP0002163_abnormal_gland_morphology1.25269909
65MP0002210_abnormal_sex_determination1.24474952
66MP0003806_abnormal_nucleotide_metabolis1.24455899
67MP0001727_abnormal_embryo_implantation1.22453415
68MP0001286_abnormal_eye_development1.21940681
69MP0004957_abnormal_blastocyst_morpholog1.19844033
70MP0005451_abnormal_body_composition1.18760510
71MP0003984_embryonic_growth_retardation1.18620530
72MP0004808_abnormal_hematopoietic_stem1.18281511
73MP0002088_abnormal_embryonic_growth/wei1.17360887
74MP0001730_embryonic_growth_arrest1.16977350
75MP0003315_abnormal_perineum_morphology1.16371238
76MP0002127_abnormal_cardiovascular_syste1.14555459
77MP0010094_abnormal_chromosome_stability1.10763384
78MP0002653_abnormal_ependyma_morphology1.09504362
79MP0003279_aneurysm1.07789507
80MP0003077_abnormal_cell_cycle1.07157984
81MP0006035_abnormal_mitochondrial_morpho1.05432670
82MP0000537_abnormal_urethra_morphology1.04020115
83MP0003121_genomic_imprinting1.04009484
84MP0005266_abnormal_metabolism1.03581549
85MP0004197_abnormal_fetal_growth/weight/1.01286479
86MP0001672_abnormal_embryogenesis/_devel1.01255193
87MP0005380_embryogenesis_phenotype1.01255193
88MP0000647_abnormal_sebaceous_gland1.01143242
89MP0004085_abnormal_heartbeat1.00924804
90MP0002332_abnormal_exercise_endurance0.99986918
91MP0003755_abnormal_palate_morphology0.99918892
92MP0009672_abnormal_birth_weight0.99601349
93MP0003111_abnormal_nucleus_morphology0.98979415
94MP0003861_abnormal_nervous_system0.97969362
95MP0010030_abnormal_orbit_morphology0.97121517
96MP0002234_abnormal_pharynx_morphology0.96791268
97MP0001697_abnormal_embryo_size0.95413774
98MP0001879_abnormal_lymphatic_vessel0.95356944
99MP0005187_abnormal_penis_morphology0.92617365
100* MP0001145_abnormal_male_reproductive0.92400733
101MP0002128_abnormal_blood_circulation0.92251774
102MP0005375_adipose_tissue_phenotype0.90433744
103MP0003828_pulmonary_edema0.89837755
104MP0005248_abnormal_Harderian_gland0.89825328
105MP0000313_abnormal_cell_death0.89555626
106MP0004185_abnormal_adipocyte_glucose0.88593357
107* MP0001929_abnormal_gametogenesis0.87625030
108MP0002089_abnormal_postnatal_growth/wei0.86318900
109MP0009053_abnormal_anal_canal0.85643465
110MP0009697_abnormal_copulation0.85474137
111MP0002080_prenatal_lethality0.84741507
112MP0001346_abnormal_lacrimal_gland0.84516607
113MP0009703_decreased_birth_body0.84487550
114MP0002111_abnormal_tail_morphology0.84444082
115MP0008260_abnormal_autophagy0.84047498
116MP0000778_abnormal_nervous_system0.83651553
117* MP0000653_abnormal_sex_gland0.82263692
118MP0005503_abnormal_tendon_morphology0.81897256
119MP0003693_abnormal_embryo_hatching0.81438203
120MP0005408_hypopigmentation0.80524854
121MP0003186_abnormal_redox_activity0.80426873
122MP0000343_altered_response_to0.80068279
123MP0002877_abnormal_melanocyte_morpholog0.79091579
124MP0003656_abnormal_erythrocyte_physiolo0.78927111
125MP0002139_abnormal_hepatobiliary_system0.78552951
126MP0009384_cardiac_valve_regurgitation0.78547255
127MP0001324_abnormal_eye_pigmentation0.78052732
128MP0002086_abnormal_extraembryonic_tissu0.77552755
129MP0005670_abnormal_white_adipose0.77488812
130MP0005379_endocrine/exocrine_gland_phen0.77473830
131MP0003566_abnormal_cell_adhesion0.77376491
132MP0001299_abnormal_eye_distance/0.76437059
133MP0001340_abnormal_eyelid_morphology0.75833569
134MP0003935_abnormal_craniofacial_develop0.75399478
135MP0000350_abnormal_cell_proliferation0.74517682
136MP0002925_abnormal_cardiovascular_devel0.74076042
137MP0002084_abnormal_developmental_patter0.73971298
138MP0005501_abnormal_skin_physiology0.73235818
139MP0004510_myositis0.73188291
140MP0005391_vision/eye_phenotype0.71183544
141MP0000428_abnormal_craniofacial_morphol0.70246875
142MP0008961_abnormal_basal_metabolism0.69925953
143MP0005076_abnormal_cell_differentiation0.66611673
144MP0003385_abnormal_body_wall0.62591670
145MP0002085_abnormal_embryonic_tissue0.61738253
146MP0002971_abnormal_brown_adipose0.60809516
147MP0010307_abnormal_tumor_latency0.58411342
148MP0000358_abnormal_cell_content/0.58112163
149MP0008770_decreased_survivor_rate0.57563706
150MP0005319_abnormal_enzyme/_coenzyme0.56636474

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.34243501
2Exercise-induced myalgia (HP:0003738)6.21046663
3Muscle fiber inclusion bodies (HP:0100299)5.71674373
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.56148258
5Calf muscle hypertrophy (HP:0008981)5.15959802
6Muscle hypertrophy of the lower extremities (HP:0008968)5.14979123
7Myoglobinuria (HP:0002913)5.11377999
8Nemaline bodies (HP:0003798)5.06291583
9Difficulty running (HP:0009046)4.35867948
10Rhabdomyolysis (HP:0003201)4.35171949
11Sudden death (HP:0001699)4.27106311
12Type 1 muscle fiber predominance (HP:0003803)4.16368264
13Muscle fiber splitting (HP:0003555)4.07622665
14Distal arthrogryposis (HP:0005684)4.07037643
15Abnormality of the calf musculature (HP:0001430)4.00493851
16Subaortic stenosis (HP:0001682)3.99200245
17Abnormality of the left ventricular outflow tract (HP:0011103)3.99200245
18Hyporeflexia of lower limbs (HP:0002600)3.75867286
19EMG: myopathic abnormalities (HP:0003458)3.72271301
20Increased connective tissue (HP:0009025)3.72017239
21Ulnar deviation of the wrist (HP:0003049)3.49932777
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49546821
23Difficulty climbing stairs (HP:0003551)3.45029019
24Myotonia (HP:0002486)3.37162867
25Ventricular tachycardia (HP:0004756)3.33900968
26Myopathic facies (HP:0002058)3.30429397
27Muscle stiffness (HP:0003552)3.29565144
28Chromsome breakage (HP:0040012)3.27241488
29Reticulocytopenia (HP:0001896)3.08493677
30Round ear (HP:0100830)3.08366683
31Lipoatrophy (HP:0100578)3.06307679
32Asymmetric septal hypertrophy (HP:0001670)3.01315804
33Calcaneovalgus deformity (HP:0001848)2.99144641
34Abnormality of glycolysis (HP:0004366)2.90221854
35Microglossia (HP:0000171)2.85890777
36Limb-girdle muscle atrophy (HP:0003797)2.82779952
37Atrial fibrillation (HP:0005110)2.82449095
38Abnormality of skeletal muscle fiber size (HP:0012084)2.79577348
39Meckel diverticulum (HP:0002245)2.76485392
40Pelvic girdle muscle weakness (HP:0003749)2.73621808
41Deformed tarsal bones (HP:0008119)2.73135299
42Rimmed vacuoles (HP:0003805)2.71999418
43Cortical dysplasia (HP:0002539)2.70413330
44Primary atrial arrhythmia (HP:0001692)2.65630054
45Palpitations (HP:0001962)2.62832662
46Supraventricular tachycardia (HP:0004755)2.62283523
47Microvesicular hepatic steatosis (HP:0001414)2.60690977
48Increased serum pyruvate (HP:0003542)2.60280886
49Increased variability in muscle fiber diameter (HP:0003557)2.58783541
50Abnormality of the ileum (HP:0001549)2.58534025
51Supraventricular arrhythmia (HP:0005115)2.58258300
52Areflexia of lower limbs (HP:0002522)2.56873714
53Birth length less than 3rd percentile (HP:0003561)2.55476753
54Abnormality of the musculature of the pelvis (HP:0001469)2.54969401
55Abnormality of the hip-girdle musculature (HP:0001445)2.54969401
56Shoulder girdle muscle weakness (HP:0003547)2.54385110
57Absent phalangeal crease (HP:0006109)2.53330483
58Dilated cardiomyopathy (HP:0001644)2.48941786
59Bundle branch block (HP:0011710)2.47068457
60Frequent falls (HP:0002359)2.42392688
61Neck muscle weakness (HP:0000467)2.41937158
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41295016
63Abnormality of alanine metabolism (HP:0010916)2.41295016
64Hyperalaninemia (HP:0003348)2.41295016
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.39122142
66Septo-optic dysplasia (HP:0100842)2.38372249
67Progressive muscle weakness (HP:0003323)2.37666528
68Abnormality of chromosome stability (HP:0003220)2.36223998
69Horseshoe kidney (HP:0000085)2.33674299
70Absent septum pellucidum (HP:0001331)2.31109665
71Atrioventricular block (HP:0001678)2.26360054
72Ectopic kidney (HP:0000086)2.26243899
73Limb-girdle muscle weakness (HP:0003325)2.23120055
74Abnormality of the pons (HP:0007361)2.21292156
75Multiple enchondromatosis (HP:0005701)2.20734744
76Abnormality of the calcaneus (HP:0008364)2.20615483
77Increased nuchal translucency (HP:0010880)2.19430477
78Abnormal finger flexion creases (HP:0006143)2.16160877
79Progressive external ophthalmoplegia (HP:0000590)2.14188851
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13850534
81Reduced antithrombin III activity (HP:0001976)2.13798730
82Ragged-red muscle fibers (HP:0003200)2.12440073
83Ventricular arrhythmia (HP:0004308)2.10708681
84Proximal amyotrophy (HP:0007126)2.10690331
85Conjunctival hamartoma (HP:0100780)2.09001536
86Abnormality of the carotid arteries (HP:0005344)2.08613520
87Abnormality of the septum pellucidum (HP:0007375)2.08352060
88Heart block (HP:0012722)2.07570513
89Septate vagina (HP:0001153)2.06690874
90Congenital primary aphakia (HP:0007707)2.06437269
91Abnormality of the preputium (HP:0100587)2.05783869
92Hypoplasia of the pons (HP:0012110)2.05601674
93Right ventricular cardiomyopathy (HP:0011663)2.04614531
94Hypoplastic pelvis (HP:0008839)2.03790569
95Nephrogenic diabetes insipidus (HP:0009806)2.03743155
96Abnormality of cells of the erythroid lineage (HP:0012130)2.02297259
97Medial flaring of the eyebrow (HP:0010747)2.01975825
98Overlapping toe (HP:0001845)2.00619870
99Neoplasm of head and neck (HP:0012288)1.97818905
100Esophageal neoplasm (HP:0100751)1.97818905
101Facial cleft (HP:0002006)1.96815890
102Gait imbalance (HP:0002141)1.94592046
103Macrocytic anemia (HP:0001972)1.93034969
104Abnormal lung lobation (HP:0002101)1.92927148
105Protrusio acetabuli (HP:0003179)1.92039698
106EMG: neuropathic changes (HP:0003445)1.91799266
107Increased hepatocellular lipid droplets (HP:0006565)1.91565939
108Abnormal atrioventricular conduction (HP:0005150)1.91471344
109Postnatal microcephaly (HP:0005484)1.90266924
110Increased density of long bones (HP:0006392)1.90196468
111Proximal placement of thumb (HP:0009623)1.89912407
112Malignant hyperthermia (HP:0002047)1.89482561
113Hypoplastic ischia (HP:0003175)1.88711624
114Angiofibromas (HP:0010615)1.87991136
115Adenoma sebaceum (HP:0009720)1.87991136
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.87919928
117Poor coordination (HP:0002370)1.86685660
118Neoplasm of the adrenal gland (HP:0100631)1.82811645
119Dysmetric saccades (HP:0000641)1.82727305
120Facial diplegia (HP:0001349)1.82023443
121Abnormal number of erythroid precursors (HP:0012131)1.81341850
122Lipid accumulation in hepatocytes (HP:0006561)1.80501547
123Vaginal atresia (HP:0000148)1.80271932
124Lymphangioma (HP:0100764)1.79531263
125Type I transferrin isoform profile (HP:0003642)1.78548130
126Ventricular fibrillation (HP:0001663)1.77503677
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76404905
128Volvulus (HP:0002580)1.73770809
129Renal duplication (HP:0000075)1.73551312
130Abnormal protein glycosylation (HP:0012346)1.73321204
131Abnormal glycosylation (HP:0012345)1.73321204
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73321204
133Abnormal protein N-linked glycosylation (HP:0012347)1.73321204
134Achilles tendon contracture (HP:0001771)1.72221666
135Scapular winging (HP:0003691)1.71606836
136Prolonged QT interval (HP:0001657)1.71590857
137Deviation of the thumb (HP:0009603)1.70922766
138Increased muscle lipid content (HP:0009058)1.70527450
139Mildly elevated creatine phosphokinase (HP:0008180)1.70055748
140Abnormality of the 4th metacarpal (HP:0010012)1.68791970
141Breast hypoplasia (HP:0003187)1.68338456
142Facial hemangioma (HP:0000329)1.67141577
143Genital tract atresia (HP:0001827)1.66744283
144Overriding aorta (HP:0002623)1.66423326
145Cholelithiasis (HP:0001081)1.66057950
146Increased serum lactate (HP:0002151)1.64598498
147Upper limb muscle weakness (HP:0003484)1.64574811
148Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64281779
149Sloping forehead (HP:0000340)1.64202345
150Abnormality of DNA repair (HP:0003254)1.64078233
151Bifid tongue (HP:0010297)1.63984578
152Muscular dystrophy (HP:0003560)1.63672134
153Hamartoma of the eye (HP:0010568)1.63507192
154Asymmetry of the thorax (HP:0001555)1.63137833
155Increased CSF lactate (HP:0002490)1.62530915
156Insidious onset (HP:0003587)1.62219886
157Termporal pattern (HP:0011008)1.62219886
158Neoplasm of the rectum (HP:0100743)1.61078216
159Hypoglycemic coma (HP:0001325)1.61051134
160Rectal prolapse (HP:0002035)1.60793498
161Triphalangeal thumb (HP:0001199)1.60253341
162Distal lower limb muscle weakness (HP:0009053)1.60049832
163Hemivertebrae (HP:0002937)1.59826775
164Abnormality of reticulocytes (HP:0004312)1.59783227
165Adrenal hypoplasia (HP:0000835)1.59325835
166Broad metatarsal (HP:0001783)1.58900499
167Abnormality of the Achilles tendon (HP:0005109)1.58879218
168Ketoacidosis (HP:0001993)1.58811332
169Abnormal mitochondria in muscle tissue (HP:0008316)1.58613958
170Acute necrotizing encephalopathy (HP:0006965)1.58241163
171Duplication of thumb phalanx (HP:0009942)1.58108254
172Hepatic necrosis (HP:0002605)1.57996388
173Abnormality of the shoulder girdle musculature (HP:0001435)1.56943801
174Squamous cell carcinoma (HP:0002860)1.55556681
175Syncope (HP:0001279)1.55391561
176Premature ovarian failure (HP:0008209)1.54707485
177Duodenal stenosis (HP:0100867)1.54593472
178Small intestinal stenosis (HP:0012848)1.54593472
179Degeneration of anterior horn cells (HP:0002398)1.54446032
180Abnormality of the anterior horn cell (HP:0006802)1.54446032
181Absent epiphyses (HP:0010577)1.54252902
182Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54252902
183Anophthalmia (HP:0000528)1.53445551
184Acute encephalopathy (HP:0006846)1.52397067
185Partial agenesis of the corpus callosum (HP:0001338)1.52211786
186Aplasia/Hypoplasia of the tongue (HP:0010295)1.52019779
187Short thumb (HP:0009778)1.51671523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.00775238
2PKN24.43221888
3TRIB34.29428327
4OBSCN4.13137623
5NEK13.73058699
6PBK3.42739801
7SRPK12.84252186
8PHKG22.75136233
9PHKG12.75136233
10STK242.53816677
11DMPK2.41758198
12MAP2K32.40184378
13EIF2AK32.15423312
14BCKDK2.09376361
15STK162.09362765
16CDK82.06160626
17TRIM282.05648443
18PDK32.01225149
19PDK42.01225149
20BMPR1B2.00934573
21PNCK1.93082061
22TSSK61.86091866
23CDC71.73510802
24WEE11.73141078
25FLT31.72538083
26IRAK31.69795252
27STK31.67136948
28MAP3K101.62534375
29EEF2K1.61533301
30BCR1.53418601
31PTK61.52308253
32PLK31.46344153
33CHEK21.45331174
34MAP3K71.43626809
35WNK41.37970656
36TIE11.36510558
37TGFBR11.35302391
38RIPK11.26727488
39PLK41.25104983
40LMTK21.19796353
41ACVR1B1.19680643
42LRRK21.19413149
43MKNK21.17787836
44NEK21.14133389
45SCYL21.13448516
46TAF11.12678836
47MAP3K91.12409083
48ILK1.10730247
49CDK41.09469579
50MAP3K31.07068921
51ERBB40.99556615
52BRSK20.98449006
53MAP3K50.97443616
54NME10.97416505
55MAP3K110.96719113
56NME20.95410037
57LATS20.95368950
58NEK90.89579701
59MAPKAPK30.88525768
60MUSK0.87018368
61RPS6KB20.86598288
62PIK3CG0.86098058
63CAMK1G0.86036303
64VRK10.85692274
65DYRK1B0.84190522
66TYRO30.83776557
67TAOK20.82841901
68RPS6KA40.82054628
69TTK0.81467681
70EPHA20.80497723
71ERBB30.78386048
72MAP2K40.78137709
73PIK3CA0.78009790
74PINK10.77885580
75TAOK10.77675147
76ICK0.77657813
77ATM0.76708465
78DYRK30.76484689
79MTOR0.73714304
80BRD40.73097045
81BRAF0.72523584
82LIMK10.71454546
83PDGFRA0.71078638
84MYLK0.70243909
85AKT20.68631157
86AURKA0.68517493
87STK390.67410474
88CDK60.66374496
89KDR0.64423289
90CDK140.64046993
91EIF2AK10.63140341
92MAP3K80.62405702
93PRKD30.61096773
94MAP2K70.60832595
95VRK20.59957106
96EIF2AK20.59936012
97LATS10.57414548
98FGFR10.57000781
99CDK10.56147599
100CDK120.53441589
101ABL20.53393300
102PRKAA10.52835680
103ALK0.52260853
104CSNK2A10.51962067
105MAPK120.50634330
106CSNK2A20.50547759
107PDK20.49903397
108PASK0.48115033
109MAP3K40.47742744
110PAK40.47309950
111SIK10.47293499
112SIK30.47216684
113CDK11A0.47148662
114BMX0.46053315
115CDK90.45991395
116CSNK1A1L0.45500725
117ZAK0.45327918
118MAP2K60.45283936
119ATR0.45089232
120STK38L0.44971195
121CAMK40.44800117
122CDK180.44489757
123AURKB0.44015546
124MET0.43652565
125PLK10.42131141
126RET0.42052754
127PAK20.41472544
128STK40.40964611
129MAPK110.40812513
130TGFBR20.37270770
131PIM20.37191060
132KIT0.36735379
133CCNB10.34183868
134PRKAA20.31880562
135CAMKK10.31091905
136CDK20.29153650
137BRSK10.29127851
138MKNK10.29018565
139PRKACB0.28399997
140RPS6KA10.27917369
141BUB10.26981878
142RAF10.26227363
143* CHEK10.26216625
144PRKD10.26168043
145ROCK10.25120492
146CAMK1D0.25052447
147KSR10.24415300
148CDK70.24154133
149RPS6KL10.22604390
150RPS6KC10.22604390

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.45425022
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.92617728
3Carbon metabolism_Homo sapiens_hsa012002.68517387
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58078327
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.57406087
6Steroid biosynthesis_Homo sapiens_hsa001002.51742793
7Propanoate metabolism_Homo sapiens_hsa006402.46215446
8Dilated cardiomyopathy_Homo sapiens_hsa054142.45774268
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37438214
10Cardiac muscle contraction_Homo sapiens_hsa042602.31790142
11RNA polymerase_Homo sapiens_hsa030202.16931669
12DNA replication_Homo sapiens_hsa030302.10273217
13Biosynthesis of amino acids_Homo sapiens_hsa012301.92749846
14Fanconi anemia pathway_Homo sapiens_hsa034601.91902943
15Basal transcription factors_Homo sapiens_hsa030221.88792724
16Fatty acid degradation_Homo sapiens_hsa000711.85198169
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84539048
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75194877
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67185433
20Protein export_Homo sapiens_hsa030601.53788524
21Cell cycle_Homo sapiens_hsa041101.51792125
22Parkinsons disease_Homo sapiens_hsa050121.43878070
23Pyruvate metabolism_Homo sapiens_hsa006201.43598055
24RNA transport_Homo sapiens_hsa030131.43471198
25Insulin signaling pathway_Homo sapiens_hsa049101.37065684
26Glucagon signaling pathway_Homo sapiens_hsa049221.34944041
27Viral myocarditis_Homo sapiens_hsa054161.32705078
28Insulin resistance_Homo sapiens_hsa049311.32617095
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31757400
30Folate biosynthesis_Homo sapiens_hsa007901.31637370
31Starch and sucrose metabolism_Homo sapiens_hsa005001.30555483
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.29062245
33Fatty acid metabolism_Homo sapiens_hsa012121.28921795
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27222978
35One carbon pool by folate_Homo sapiens_hsa006701.24376209
36Fatty acid elongation_Homo sapiens_hsa000621.20933712
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16446427
38Nitrogen metabolism_Homo sapiens_hsa009101.15107724
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14981684
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14500696
41Pentose phosphate pathway_Homo sapiens_hsa000301.12391130
42AMPK signaling pathway_Homo sapiens_hsa041521.12148548
43Galactose metabolism_Homo sapiens_hsa000521.11271026
44Base excision repair_Homo sapiens_hsa034101.10427412
45Mismatch repair_Homo sapiens_hsa034301.09281487
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06863818
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.06807371
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05975542
49Vitamin B6 metabolism_Homo sapiens_hsa007501.02989019
50HIF-1 signaling pathway_Homo sapiens_hsa040661.00912902
51Thyroid cancer_Homo sapiens_hsa052160.99462677
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98760640
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98439517
54Selenocompound metabolism_Homo sapiens_hsa004500.97733148
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97060389
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96459686
57mTOR signaling pathway_Homo sapiens_hsa041500.95925273
58N-Glycan biosynthesis_Homo sapiens_hsa005100.93243935
59Ribosome_Homo sapiens_hsa030100.92585549
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.90957389
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90136006
62Spliceosome_Homo sapiens_hsa030400.88921578
63Lysine degradation_Homo sapiens_hsa003100.88368255
64Focal adhesion_Homo sapiens_hsa045100.85585331
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85192154
66Chronic myeloid leukemia_Homo sapiens_hsa052200.84415153
67Arginine biosynthesis_Homo sapiens_hsa002200.82661830
68Oocyte meiosis_Homo sapiens_hsa041140.81018694
69Hedgehog signaling pathway_Homo sapiens_hsa043400.79313812
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78301417
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75362624
72Huntingtons disease_Homo sapiens_hsa050160.74395635
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74353559
74Small cell lung cancer_Homo sapiens_hsa052220.73758838
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73478652
76Proteoglycans in cancer_Homo sapiens_hsa052050.73352042
77mRNA surveillance pathway_Homo sapiens_hsa030150.72070560
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69770414
79Fructose and mannose metabolism_Homo sapiens_hsa000510.67116159
80Glutathione metabolism_Homo sapiens_hsa004800.65678960
81TGF-beta signaling pathway_Homo sapiens_hsa043500.64661801
82Alzheimers disease_Homo sapiens_hsa050100.64586115
83Arginine and proline metabolism_Homo sapiens_hsa003300.60847251
84p53 signaling pathway_Homo sapiens_hsa041150.59123774
85Oxytocin signaling pathway_Homo sapiens_hsa049210.57801341
86Non-small cell lung cancer_Homo sapiens_hsa052230.57743032
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56802284
88Hippo signaling pathway_Homo sapiens_hsa043900.56693109
89RNA degradation_Homo sapiens_hsa030180.55949132
90Oxidative phosphorylation_Homo sapiens_hsa001900.55842094
91Homologous recombination_Homo sapiens_hsa034400.55684592
92Colorectal cancer_Homo sapiens_hsa052100.55652024
93Acute myeloid leukemia_Homo sapiens_hsa052210.54602731
94Pyrimidine metabolism_Homo sapiens_hsa002400.53365516
95Metabolic pathways_Homo sapiens_hsa011000.52283922
96HTLV-I infection_Homo sapiens_hsa051660.50621976
97Proteasome_Homo sapiens_hsa030500.50435203
98Circadian rhythm_Homo sapiens_hsa047100.49904553
99Nucleotide excision repair_Homo sapiens_hsa034200.49726603
100Basal cell carcinoma_Homo sapiens_hsa052170.49059289
101PPAR signaling pathway_Homo sapiens_hsa033200.48769433
102FoxO signaling pathway_Homo sapiens_hsa040680.47728452
103Melanoma_Homo sapiens_hsa052180.47427158
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.47335532
105Endometrial cancer_Homo sapiens_hsa052130.47173482
106Wnt signaling pathway_Homo sapiens_hsa043100.46324481
107Adherens junction_Homo sapiens_hsa045200.45935410
108Platelet activation_Homo sapiens_hsa046110.45633342
109Non-homologous end-joining_Homo sapiens_hsa034500.44639029
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42858369
111Butanoate metabolism_Homo sapiens_hsa006500.42775306
112Bladder cancer_Homo sapiens_hsa052190.42702455
113Viral carcinogenesis_Homo sapiens_hsa052030.41233126
114Vibrio cholerae infection_Homo sapiens_hsa051100.40306533
115Glioma_Homo sapiens_hsa052140.39347791
116Purine metabolism_Homo sapiens_hsa002300.38597350
117Epstein-Barr virus infection_Homo sapiens_hsa051690.37866223
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36592092
119Prostate cancer_Homo sapiens_hsa052150.35338768
120Tight junction_Homo sapiens_hsa045300.34647489
121MicroRNAs in cancer_Homo sapiens_hsa052060.33185170
122Sulfur relay system_Homo sapiens_hsa041220.32359079
123Calcium signaling pathway_Homo sapiens_hsa040200.32293939
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32264235
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31646700
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31504303
127beta-Alanine metabolism_Homo sapiens_hsa004100.30446714
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30295707
129VEGF signaling pathway_Homo sapiens_hsa043700.29683226
130Alcoholism_Homo sapiens_hsa050340.29202921
131Fatty acid biosynthesis_Homo sapiens_hsa000610.22068124
132Regulation of autophagy_Homo sapiens_hsa041400.21670859
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21241450

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