E2F6P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.88623471
2neutrophil activation involved in immune response (GO:0002283)7.34823173
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.40274501
4adenosine receptor signaling pathway (GO:0001973)6.37121424
5regulation of platelet aggregation (GO:0090330)6.06216042
6regulation of platelet activation (GO:0010543)6.00407321
7negative regulation of norepinephrine secretion (GO:0010700)5.87905883
8platelet aggregation (GO:0070527)5.68705770
9blood coagulation, intrinsic pathway (GO:0007597)5.59762696
10regulation of integrin-mediated signaling pathway (GO:2001044)5.54600250
11low-density lipoprotein particle remodeling (GO:0034374)5.31215093
12leukocyte migration involved in inflammatory response (GO:0002523)5.30479546
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.22071905
14negative regulation of platelet activation (GO:0010544)5.20847834
15negative regulation of heart rate (GO:0010459)5.18644245
16negative regulation of homotypic cell-cell adhesion (GO:0034111)5.17977730
17negative regulation of thymocyte apoptotic process (GO:0070244)4.93712191
18regulation of Golgi to plasma membrane protein transport (GO:0042996)4.93390018
19positive regulation of endothelial cell differentiation (GO:0045603)4.78875481
20lipoxygenase pathway (GO:0019372)4.63459984
21negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.61916653
22megakaryocyte development (GO:0035855)4.55131800
23purinergic nucleotide receptor signaling pathway (GO:0035590)4.47467018
24regulation of integrin activation (GO:0033623)4.43627883
25negative regulation of response to food (GO:0032096)4.36944345
26negative regulation of appetite (GO:0032099)4.36944345
27platelet degranulation (GO:0002576)4.34980094
28platelet formation (GO:0030220)4.28143847
29positive regulation of mast cell activation (GO:0033005)4.25383941
30fusion of sperm to egg plasma membrane (GO:0007342)4.23784743
31negative regulation of protein localization to cell surface (GO:2000009)4.12261771
32neutrophil activation (GO:0042119)4.09388167
33beta-amyloid metabolic process (GO:0050435)4.08717153
34angiogenesis involved in wound healing (GO:0060055)4.06637080
35regulation of lipoprotein metabolic process (GO:0050746)4.02495058
36positive regulation of systemic arterial blood pressure (GO:0003084)3.98375058
37positive regulation of macrophage differentiation (GO:0045651)3.95049231
38positive regulation of Rho protein signal transduction (GO:0035025)3.92255180
39negative regulation of heart contraction (GO:0045822)3.90345319
40G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.90119921
41positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.88613242
42negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.87091888
43polyamine biosynthetic process (GO:0006596)3.86663446
44homotypic cell-cell adhesion (GO:0034109)3.79639438
45platelet activation (GO:0030168)3.79624671
46purinergic receptor signaling pathway (GO:0035587)3.78150250
47positive regulation of cAMP-mediated signaling (GO:0043950)3.74228287
48microtubule depolymerization (GO:0007019)3.73224957
49negative regulation of catecholamine secretion (GO:0033604)3.64983153
50fatty acid elongation (GO:0030497)3.63470268
51high-density lipoprotein particle remodeling (GO:0034375)3.61345189
52regulation of norepinephrine secretion (GO:0014061)3.59769254
53regulation of homotypic cell-cell adhesion (GO:0034110)3.56083948
54extracellular fibril organization (GO:0043206)3.55858081
55granulocyte activation (GO:0036230)3.53885605
56long-chain fatty acid biosynthetic process (GO:0042759)3.53633259
57autophagic vacuole fusion (GO:0000046)3.50027879
58positive regulation of receptor recycling (GO:0001921)3.49456780
59regulation of macrophage derived foam cell differentiation (GO:0010743)3.47926701
60positive regulation of hemostasis (GO:1900048)3.43863753
61positive regulation of blood coagulation (GO:0030194)3.43863753
62sequestering of actin monomers (GO:0042989)3.43317576
63negative regulation of neural precursor cell proliferation (GO:2000178)3.37187542
64mitochondrial calcium ion transport (GO:0006851)3.33983571
65reverse cholesterol transport (GO:0043691)3.31274237
66leukocyte degranulation (GO:0043299)3.27506830
67regulation of MHC class II biosynthetic process (GO:0045346)3.26995707
68vesicle targeting (GO:0006903)3.22368817
69regulation of female receptivity (GO:0045924)3.21315316
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.19806044
71negative regulation of T-helper cell differentiation (GO:0045623)3.15085636
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15085636
73regulation of cholesterol efflux (GO:0010874)3.14723567
74regulation of memory T cell differentiation (GO:0043380)3.13505716
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11351395
76L-phenylalanine catabolic process (GO:0006559)3.11351395
77regulation of megakaryocyte differentiation (GO:0045652)3.11286387
78negative regulation of protein localization to plasma membrane (GO:1903077)3.11129115
79phospholipid homeostasis (GO:0055091)3.09211598
80negative regulation of T cell apoptotic process (GO:0070233)3.07679261
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.05973847
82regulation of endothelial cell differentiation (GO:0045601)3.05009136
83termination of G-protein coupled receptor signaling pathway (GO:0038032)3.02643231
84plasma membrane fusion (GO:0045026)3.01917034
85tyrosine metabolic process (GO:0006570)3.00080463
86positive regulation of coagulation (GO:0050820)2.99789576
87positive regulation of protein homodimerization activity (GO:0090073)2.99500172
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98431660
89cyclooxygenase pathway (GO:0019371)2.96598079
90regulation of blood coagulation (GO:0030193)2.95560646
91regulation of hemostasis (GO:1900046)2.95560646
92termination of signal transduction (GO:0023021)2.94262549
93endothelium development (GO:0003158)2.93774980
94fibril organization (GO:0097435)2.90149267
95poly(A)+ mRNA export from nucleus (GO:0016973)2.89934875
96negative regulation of blood circulation (GO:1903523)2.89643571
97relaxation of smooth muscle (GO:0044557)2.85631457
98regulation of receptor recycling (GO:0001919)2.82220140
99positive regulation of granulocyte differentiation (GO:0030854)2.81850830
100protein neddylation (GO:0045116)10.5056348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human5.32232455
2SCL_19346495_ChIP-Seq_HPC-7_Human4.59736877
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.44092067
4GATA1_19941826_ChIP-Seq_K562_Human3.69266768
5GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.47390019
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43670469
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.21892993
8GATA2_19941826_ChIP-Seq_K562_Human3.19062803
9LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.87380176
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.86618018
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.61311942
12HTT_18923047_ChIP-ChIP_STHdh_Human2.57963138
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54152795
14SPI1_23127762_ChIP-Seq_K562_Human2.49959443
15TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.49837755
16GATA1_22025678_ChIP-Seq_K562_Human2.47657186
17GATA1_22383799_ChIP-Seq_G1ME_Mouse2.47230248
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46641986
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37526085
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29653398
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22579359
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16061408
23ELK4_26923725_Chip-Seq_MESODERM_Mouse2.15422100
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.14802295
25EZH2_22144423_ChIP-Seq_EOC_Human2.09470768
26GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.09022506
27GATA2_21666600_ChIP-Seq_HMVEC_Human2.08099992
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.86103295
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84129679
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83386876
31NCOR1_26117541_ChIP-Seq_K562_Human1.76887882
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76424654
33E2F7_22180533_ChIP-Seq_HELA_Human1.73275914
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69778025
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68604726
36GATA1_19941827_ChIP-Seq_MEL86_Mouse1.65113377
37SALL4_22934838_ChIP-ChIP_CD34+_Human1.58119270
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57309886
39GBX2_23144817_ChIP-Seq_PC3_Human1.55313772
40ETS1_22383799_ChIP-Seq_G1ME_Mouse1.50279289
41TAF15_26573619_Chip-Seq_HEK293_Human1.47705565
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47304229
43VDR_22108803_ChIP-Seq_LS180_Human1.45375096
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44888448
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43109548
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38683284
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37160037
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33993908
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33142483
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31773441
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.31290681
52KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30303612
53SPI1_20517297_ChIP-Seq_HL60_Human1.21999990
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20262279
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12191189
56EWS_26573619_Chip-Seq_HEK293_Human1.10481122
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09963586
58STAT1_20625510_ChIP-Seq_HELA_Human1.09654554
59SPI1_23547873_ChIP-Seq_NB4_Human1.07233192
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07166317
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07123906
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06683516
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06612483
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06612483
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04665300
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02280090
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00278524
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99630507
69LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97071681
70UTX_26944678_Chip-Seq_JUKART_Human0.96100581
71RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95400201
72EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94617127
73RUNX_20019798_ChIP-Seq_JUKART_Human0.93635425
74BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92149439
75MYB_26560356_Chip-Seq_TH2_Human0.91273111
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.91046340
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90213047
78IRF1_19129219_ChIP-ChIP_H3396_Human0.89972810
79RBPJ_21746931_ChIP-Seq_IB4_Human0.88085072
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87974195
81WT1_19549856_ChIP-ChIP_CCG9911_Human0.86918643
82TCF4_18268006_ChIP-ChIP_LS174T_Human0.85414647
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.85081864
84ERG_20517297_ChIP-Seq_VCAP_Human0.84341812
85OCT1_27270436_Chip-Seq_PROSTATE_Human0.84005641
86E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82372666
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81514626
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81365074
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81316253
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.81307480
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80408513
92GATA4_25053715_ChIP-Seq_YYC3_Human0.79756333
93GATA3_27048872_Chip-Seq_THYMUS_Human0.79133746
94P53_22387025_ChIP-Seq_ESCs_Mouse0.78788563
95SOX2_22085726_ChIP-Seq_NPCs_Mouse0.78714676
96HNFA_21074721_ChIP-Seq_CACO-2_Human0.78597094
97NFYA_21822215_ChIP-Seq_K562_Human0.74577682
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74251312
99GATA3_26560356_Chip-Seq_TH2_Human0.73795107
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.72466445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.15040955
2MP0003724_increased_susceptibility_to3.23845724
3MP0000465_gastrointestinal_hemorrhage2.90682318
4MP0005083_abnormal_biliary_tract2.66616247
5MP0000343_altered_response_to2.53331298
6MP0003566_abnormal_cell_adhesion2.26483059
7MP0004084_abnormal_cardiac_muscle2.21766438
8MP0009697_abnormal_copulation2.16881638
9MP0000230_abnormal_systemic_arterial2.14292648
10MP0004510_myositis2.14037786
11MP0002736_abnormal_nociception_after2.13954016
12MP0001835_abnormal_antigen_presentation2.09261172
13MP0005410_abnormal_fertilization2.04583966
14MP0005464_abnormal_platelet_physiology10.4169539
15MP0003303_peritoneal_inflammation1.97535942
16MP0008775_abnormal_heart_ventricle1.87580684
17MP0008872_abnormal_physiological_respon1.85127261
18MP0001879_abnormal_lymphatic_vessel1.84231544
19MP0003638_abnormal_response/metabolism_1.79711486
20MP0005646_abnormal_pituitary_gland1.64846356
21MP0003828_pulmonary_edema1.64414739
22MP0004036_abnormal_muscle_relaxation1.63751576
23MP0005671_abnormal_response_to1.62179202
24MP0005167_abnormal_blood-brain_barrier1.60071648
25MP0005084_abnormal_gallbladder_morpholo1.59762035
26MP0001545_abnormal_hematopoietic_system1.58728826
27MP0005397_hematopoietic_system_phenotyp1.58728826
28MP0010155_abnormal_intestine_physiology1.57050133
29MP0002398_abnormal_bone_marrow1.52574995
30MP0005058_abnormal_lysosome_morphology1.48053065
31MP0004130_abnormal_muscle_cell1.44730595
32MP0002132_abnormal_respiratory_system1.43487669
33MP0001851_eye_inflammation1.41373312
34MP0002148_abnormal_hypersensitivity_rea1.41138215
35MP0003656_abnormal_erythrocyte_physiolo1.37290620
36MP0002877_abnormal_melanocyte_morpholog1.33948720
37MP0009763_increased_sensitivity_to1.29891513
38MP0001663_abnormal_digestive_system1.27857552
39MP0004947_skin_inflammation1.25952309
40MP0003879_abnormal_hair_cell1.23946852
41MP0000249_abnormal_blood_vessel1.22318173
42MP0005000_abnormal_immune_tolerance1.22092426
43MP0004215_abnormal_myocardial_fiber1.21882860
44MP0002733_abnormal_thermal_nociception1.19043127
45MP0004147_increased_porphyrin_level1.17265058
46MP0010329_abnormal_lipoprotein_level1.17050009
47MP0006276_abnormal_autonomic_nervous1.14990802
48MP0001968_abnormal_touch/_nociception1.13444114
49MP0000689_abnormal_spleen_morphology1.12393621
50MP0000858_altered_metastatic_potential1.11381669
51MP0008932_abnormal_embryonic_tissue1.09792189
52MP0002429_abnormal_blood_cell1.08401391
53MP0003718_maternal_effect1.06150669
54MP0002722_abnormal_immune_system1.03869743
55MP0006036_abnormal_mitochondrial_physio1.03313492
56MP0009642_abnormal_blood_homeostasis0.97619866
57MP0005666_abnormal_adipose_tissue0.95395136
58MP0002723_abnormal_immune_serum0.93478269
59MP0005501_abnormal_skin_physiology0.92691233
60MP0009333_abnormal_splenocyte_physiolog0.92468315
61MP0000358_abnormal_cell_content/0.89782242
62MP0008874_decreased_physiological_sensi0.89300221
63MP0009765_abnormal_xenobiotic_induced0.89202394
64MP0001765_abnormal_ion_homeostasis0.87505317
65MP0001544_abnormal_cardiovascular_syste0.86019559
66MP0005385_cardiovascular_system_phenoty0.86019559
67MP0002972_abnormal_cardiac_muscle0.84062147
68MP0002452_abnormal_antigen_presenting0.83788015
69MP0006035_abnormal_mitochondrial_morpho0.82921980
70MP0003136_yellow_coat_color0.82313280
71MP0001533_abnormal_skeleton_physiology0.81678669
72MP0005381_digestive/alimentary_phenotyp0.81617380
73MP0004134_abnormal_chest_morphology0.81191790
74MP0006138_congestive_heart_failure0.80203659
75MP0000703_abnormal_thymus_morphology0.79389430
76MP0000716_abnormal_immune_system0.79159995
77MP0005409_darkened_coat_color0.79045309
78MP0000015_abnormal_ear_pigmentation0.77562147
79MP0003186_abnormal_redox_activity0.76859580
80MP0004808_abnormal_hematopoietic_stem0.75306850
81MP0005165_increased_susceptibility_to0.75279619
82MP0001800_abnormal_humoral_immune0.74999437
83MP0002420_abnormal_adaptive_immunity0.74778984
84MP0005023_abnormal_wound_healing0.74692335
85MP0005174_abnormal_tail_pigmentation0.74030983
86MP0001661_extended_life_span0.73937192
87MP0001819_abnormal_immune_cell0.73705394
88MP0003111_abnormal_nucleus_morphology0.72527499
89MP0008877_abnormal_DNA_methylation0.72444615
90MP0005187_abnormal_penis_morphology0.72187562
91MP0001845_abnormal_inflammatory_respons0.71016981
92MP0000490_abnormal_crypts_of0.70137211
93MP0002128_abnormal_blood_circulation0.69410524
94MP0009780_abnormal_chondrocyte_physiolo0.67768543
95MP0003866_abnormal_defecation0.67485658
96MP0005535_abnormal_body_temperature0.66776249
97MP0001970_abnormal_pain_threshold0.66588857
98MP0003436_decreased_susceptibility_to0.65937113
99MP0009764_decreased_sensitivity_to0.64591413
100MP0006054_spinal_hemorrhage0.64358739

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.97686449
2Petechiae (HP:0000967)9.35902119
3Abnormal platelet volume (HP:0011876)9.31433309
4Purpura (HP:0000979)8.21226444
5Epistaxis (HP:0000421)7.52496217
6Hyperlipoproteinemia (HP:0010980)6.41094553
7Gingival bleeding (HP:0000225)6.30729520
8Abnormal platelet function (HP:0011869)6.04955487
9Impaired platelet aggregation (HP:0003540)6.04955487
10Dyschromatopsia (HP:0007641)5.68658552
11Poikilocytosis (HP:0004447)4.75306446
12Acanthocytosis (HP:0001927)4.71085508
13Abnormal pupillary function (HP:0007686)4.16532488
14Spontaneous hematomas (HP:0007420)4.03245502
15Paralysis (HP:0003470)3.85535927
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.84142453
17Conjunctival telangiectasia (HP:0000524)3.66277519
18Abnormality of the common coagulation pathway (HP:0010990)3.60271998
19Upper limb muscle weakness (HP:0003484)3.40337205
20Bruising susceptibility (HP:0000978)3.30100390
21Abnormality of the vasculature of the conjunctiva (HP:0008054)3.18676527
22Abnormal auditory evoked potentials (HP:0006958)3.12383063
23Abnormality of lateral ventricle (HP:0030047)2.94059774
24Tinnitus (HP:0000360)2.92150679
25Decreased central vision (HP:0007663)2.84842197
26Male infertility (HP:0003251)2.77063000
27Hepatosplenomegaly (HP:0001433)2.73087794
28Xanthomatosis (HP:0000991)2.65838279
29Joint swelling (HP:0001386)2.57172430
30Joint hemorrhage (HP:0005261)2.50083974
31Increased density of long bones (HP:0006392)2.47630161
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.35446741
33Nausea (HP:0002018)2.35083483
34Hyperthyroidism (HP:0000836)2.33919468
35Generalized aminoaciduria (HP:0002909)2.33560372
36Increased IgM level (HP:0003496)2.32405290
37Papillary thyroid carcinoma (HP:0002895)2.30234816
38Spontaneous abortion (HP:0005268)2.28392760
39Thyroid-stimulating hormone excess (HP:0002925)2.17850431
40Abnormal gallbladder physiology (HP:0012438)2.13045428
41Cholecystitis (HP:0001082)2.13045428
42Abnormality of iron homeostasis (HP:0011031)2.12182855
43Tongue fasciculations (HP:0001308)2.10868589
44Dysautonomia (HP:0002459)2.08755979
45Polycythemia (HP:0001901)2.03616506
46Ventricular fibrillation (HP:0001663)2.00376823
47Prolonged bleeding time (HP:0003010)11.1022647
48Menorrhagia (HP:0000132)10.0359248
49Biliary tract neoplasm (HP:0100574)1.97597431
50Autoimmune hemolytic anemia (HP:0001890)1.96028028
51Renal Fanconi syndrome (HP:0001994)1.90857504
52Hypophosphatemic rickets (HP:0004912)1.89334052
533-Methylglutaconic aciduria (HP:0003535)1.89101802
54Insidious onset (HP:0003587)1.88159141
55Termporal pattern (HP:0011008)1.88159141
56Thrombocytosis (HP:0001894)1.86744002
57Abnormality of transition element cation homeostasis (HP:0011030)1.84112963
58Stomatitis (HP:0010280)1.83441244
59Abnormality of macrophages (HP:0004311)1.83318769
60Muscle fibrillation (HP:0010546)1.83233895
61Arterial thrombosis (HP:0004420)1.82402367
62Abnormal ciliary motility (HP:0012262)1.82354052
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79179609
64Thyroid carcinoma (HP:0002890)1.78517277
65Abnormality of the prostate (HP:0008775)1.73264547
66Leiomyosarcoma (HP:0100243)1.71969921
67Uterine leiomyosarcoma (HP:0002891)1.71969921
68Ileus (HP:0002595)1.70634850
69Truncus arteriosus (HP:0001660)1.66475087
70Distal lower limb amyotrophy (HP:0008944)1.65288101
71Myocardial infarction (HP:0001658)1.64218445
72Transitional cell carcinoma of the bladder (HP:0006740)1.62947893
73Central scotoma (HP:0000603)1.61762583
74Obstructive lung disease (HP:0006536)1.61266910
75Chronic obstructive pulmonary disease (HP:0006510)1.61266910
76Back pain (HP:0003418)1.60937601
77Infertility (HP:0000789)1.58183447
78Increased serum ferritin (HP:0003281)1.56869696
79Neoplasm of the rectum (HP:0100743)1.56822055
80Testicular neoplasm (HP:0010788)1.56114407
81Abnormal spermatogenesis (HP:0008669)1.54858731
82Encephalitis (HP:0002383)1.50667479
83Pancreatic islet-cell hyperplasia (HP:0004510)1.49930087
84Episodic fever (HP:0001954)1.47313872
85Abnormal respiratory epithelium morphology (HP:0012253)1.47012035
86Abnormal respiratory motile cilium morphology (HP:0005938)1.47012035
87Exertional dyspnea (HP:0002875)1.46968703
88Bladder neoplasm (HP:0009725)1.45427955
89Bladder carcinoma (HP:0002862)1.45427955
90Vertigo (HP:0002321)1.44599571
91Amaurosis fugax (HP:0100576)1.42925784
92Abnormal large intestine physiology (HP:0012700)1.40581181
93Delayed puberty (HP:0000823)1.40410836
94Basal ganglia calcification (HP:0002135)1.40026656
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.39629635
96Mucosal telangiectasiae (HP:0100579)1.39103379
97Cerebral hemorrhage (HP:0001342)1.38704856
98Polyphagia (HP:0002591)1.38674357
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.38544618
100Myelodysplasia (HP:0002863)1.37170306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.39350961
2RIPK45.20144253
3EIF2AK14.44946141
4BMX4.30702750
5MYLK3.67531149
6TEC3.05582011
7BTK2.93212169
8PTK2B2.49277037
9PIK3CG2.38610493
10BMPR22.24427978
11TAOK32.18092958
12ILK2.09944346
13STK31.98943754
14SYK1.96716349
15GRK51.93760731
16CSF1R1.87909406
17TRIM281.79027089
18ZAP701.71173746
19PLK21.54696685
20FGR1.42724821
21PAK11.42021572
22GRK61.36985491
23PNCK1.35474856
24MAPKAPK31.33000624
25ACVR1B1.30732855
26SIK31.19649446
27HCK1.18515134
28BRSK21.18063978
29TNIK1.13054598
30MATK1.06481978
31LMTK21.02395379
32RET1.00577527
33LYN0.98540501
34DAPK30.96999661
35TLK10.96554399
36STK240.93552982
37STK40.93055474
38ADRBK20.88295214
39MARK30.87991908
40NUAK10.86802014
41ITK0.85233907
42PLK30.78968711
43IKBKB0.77962905
44TNK20.75628824
45FES0.75272575
46PIM20.73626767
47ZAK0.72242238
48MINK10.71394339
49EPHA30.68229565
50IRAK10.66105022
51MAP3K50.63517498
52MAP2K30.62776283
53FER0.62773550
54BMPR1B0.62581603
55ADRBK10.61447279
56PRKD10.61296952
57PKN10.59594183
58IRAK30.59458084
59ERBB20.57769534
60BLK0.57561729
61TAOK20.57377459
62CCNB10.56318445
63MAP2K10.49549445
64VRK10.48949804
65PRKACG0.47889220
66CDK80.47650824
67TXK0.45457525
68TESK20.45428519
69CDC70.44846112
70JAK20.44616123
71DAPK10.44023310
72RAF10.42772930
73PRKG10.41527263
74PLK40.40661530
75EPHB20.37991656
76FLT30.37232970
77YES10.35890293
78PDK10.35600745
79DYRK30.34969320
80ARAF0.34238310
81PKN20.33436402
82PRKCB0.33073496
83CDK140.31861988
84LCK0.30619101
85PAK20.29182009
86DAPK20.26555809
87FYN0.26409049
88PDGFRB0.26260056
89PRKCD0.25920541
90MAPK120.24673361
91JAK30.22970095
92IGF1R0.21284374
93AURKA0.20871548
94PRKCQ0.20610683
95ROCK10.19824312
96PRKCA0.19723372
97MKNK10.19291794
98PIM10.18687707
99SRC0.18435572
100CSK0.18074432

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046116.10042985
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051304.26680320
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.68523748
4Mismatch repair_Homo sapiens_hsa034302.92724183
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.68112786
6Nitrogen metabolism_Homo sapiens_hsa009102.59984032
7Arachidonic acid metabolism_Homo sapiens_hsa005902.22586723
8ECM-receptor interaction_Homo sapiens_hsa045122.18653569
9Hematopoietic cell lineage_Homo sapiens_hsa046402.15474699
10Gap junction_Homo sapiens_hsa045402.14505990
11Fatty acid elongation_Homo sapiens_hsa000621.93055303
12Alcoholism_Homo sapiens_hsa050341.91260960
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90996755
14Serotonergic synapse_Homo sapiens_hsa047261.88991654
15Chemokine signaling pathway_Homo sapiens_hsa040621.79379118
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.73682106
17Systemic lupus erythematosus_Homo sapiens_hsa053221.70052887
18Collecting duct acid secretion_Homo sapiens_hsa049661.54095930
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40416665
20Shigellosis_Homo sapiens_hsa051311.39148545
21Glycerolipid metabolism_Homo sapiens_hsa005611.30831221
22Sulfur metabolism_Homo sapiens_hsa009201.30532596
23Glutathione metabolism_Homo sapiens_hsa004801.30266705
24One carbon pool by folate_Homo sapiens_hsa006701.30257528
25Endocytosis_Homo sapiens_hsa041441.26380249
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20562593
27B cell receptor signaling pathway_Homo sapiens_hsa046621.16164048
28Pancreatic secretion_Homo sapiens_hsa049721.14302057
29Pentose phosphate pathway_Homo sapiens_hsa000301.11884729
30Olfactory transduction_Homo sapiens_hsa047401.08861920
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.03587245
32Starch and sucrose metabolism_Homo sapiens_hsa005001.01402327
33Long-term depression_Homo sapiens_hsa047300.93904252
34Linoleic acid metabolism_Homo sapiens_hsa005910.93778350
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91246316
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91011489
37Choline metabolism in cancer_Homo sapiens_hsa052310.89238701
38Viral carcinogenesis_Homo sapiens_hsa052030.89009457
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88203095
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.87371492
41Pancreatic cancer_Homo sapiens_hsa052120.86645256
42Steroid biosynthesis_Homo sapiens_hsa001000.81257128
43T cell receptor signaling pathway_Homo sapiens_hsa046600.79994030
44Non-small cell lung cancer_Homo sapiens_hsa052230.76496037
45DNA replication_Homo sapiens_hsa030300.75180833
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74139779
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74086603
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73839950
49Focal adhesion_Homo sapiens_hsa045100.73299321
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72893866
51Circadian entrainment_Homo sapiens_hsa047130.72469904
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70924256
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69288650
54Endometrial cancer_Homo sapiens_hsa052130.68486737
55Melanoma_Homo sapiens_hsa052180.68424877
56Thyroid cancer_Homo sapiens_hsa052160.67837902
57Purine metabolism_Homo sapiens_hsa002300.67325625
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65507201
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64919480
60Glioma_Homo sapiens_hsa052140.64821509
61Morphine addiction_Homo sapiens_hsa050320.64332914
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62122944
63Rap1 signaling pathway_Homo sapiens_hsa040150.61496041
64Primary immunodeficiency_Homo sapiens_hsa053400.61184263
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58591214
66Fat digestion and absorption_Homo sapiens_hsa049750.58480911
67Ras signaling pathway_Homo sapiens_hsa040140.57080501
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.53976556
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.52127950
70Cell cycle_Homo sapiens_hsa041100.50174404
71Nucleotide excision repair_Homo sapiens_hsa034200.49553003
72Calcium signaling pathway_Homo sapiens_hsa040200.49166986
73Homologous recombination_Homo sapiens_hsa034400.48928432
74Phagosome_Homo sapiens_hsa041450.48786778
75GABAergic synapse_Homo sapiens_hsa047270.48630655
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48538865
77Renin-angiotensin system_Homo sapiens_hsa046140.48333717
78Malaria_Homo sapiens_hsa051440.46430290
79Renal cell carcinoma_Homo sapiens_hsa052110.46249748
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43339642
81Pyrimidine metabolism_Homo sapiens_hsa002400.42754157
82Small cell lung cancer_Homo sapiens_hsa052220.42257196
83VEGF signaling pathway_Homo sapiens_hsa043700.41978425
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40827440
85Phototransduction_Homo sapiens_hsa047440.40179919
86Galactose metabolism_Homo sapiens_hsa000520.37991039
87Cholinergic synapse_Homo sapiens_hsa047250.36115980
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36067944
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34844287
90Apoptosis_Homo sapiens_hsa042100.32418616
91Chronic myeloid leukemia_Homo sapiens_hsa052200.31823542
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29532527
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29431995
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28631998
95HIF-1 signaling pathway_Homo sapiens_hsa040660.27859689
96Legionellosis_Homo sapiens_hsa051340.27525939
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27193087
98Sphingolipid metabolism_Homo sapiens_hsa006000.26185184
99Chemical carcinogenesis_Homo sapiens_hsa052040.22887798
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22882162

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